Hub : Genes

PIH1D2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Frontal Cortex BA9 0.3035 0.1049 0.00027 -0.004 NA 0.085 NA 0.032 0.44 NA 0.0029 NA 0.049
2 TCGA Brain Lower Grade Glioma 0.0809 0.0448 0.00750 0.004 0.017 0.011 NA 0.013 0.10 0.0039 0.0190 NA 0.010

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.5 0.9 1.0 0.0
Bipolar Disorder or Schizophrenia 0.5 1.1 2.2 -1.5 -0.2
Depressed Affect (Nagel 2018) 0.3 0.6 0.8 -0.9 -0.7
Depression (Nagel 2018) 0.3 0.5 0.7 -0.8 -0.5
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.1 -1.1 -0.9
Neuroticism (Nagel 2018) 0.7 1.6 3.0 -1.7 -0.4
Schizophrenia (2018) 1.8 3.7 7.4 -2.7 0.0
Schizophrenia vs Biploar Disorder 2.9 3.9 7.7 -2.8 0.0
Worry (Nagel 2018) 0.9 2.0 3.9 -2.0 0.0
Alzheimer’s Disease (in mother) 3.4 4.0 4.5 2.1 1.8
Alzheimer’s Disease (in father) 0.3 0.3 0.4 -0.4 -0.6
Alzheimer’s Disease (including proxy) 1.4 2.0 2.9 1.1 1.7
Crohns Disease (2017) 0.0 0.1 0.1 0.4 -0.1
Irritable Bowel Disease (IBD) 0.5 1.3 2.4 1.5 0.4
Ulcerative Colitis (UC) 0.7 1.3 2.1 1.4 0.7
Major Depression (MDD) 0.0 0.0 0.1 -0.3 0.0
Reaction Time 0.8 1.6 2.7 0.6 1.7
Verbal and Numeric Reasoning (VNR) 0.2 0.6 0.8 -0.6 -0.9
Breast Cancer 2.4 5.9 11.0 3.3 -0.9
Ovarian Cancer 0.1 0.1 0.2 0.5 -0.3
Prostate Cancer 1.6 2.2 3.1 1.8 -1.1
Age at First Birth 0.4 0.5 1.0 1.0 0.0
Bipolar Disorder (2011) 0.3 0.3 0.5 -0.7 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 1.3 -1.2 1.1
Coronary Artery Disease (CAD) 2.1 2.6 5.1 2.3 0.0
Crohns Disease (2012) 0.1 0.2 0.4 0.1 -0.6
Mean Putamen Volume 0.4 0.5 0.7 -0.8 0.5
Fasting Glucose 1.3 1.6 3.0 -0.3 1.7
HbA1C 0.3 0.4 0.5 0.5 -0.7
HDL Cholesterol 0.5 0.8 1.6 -1.3 0.0
LDL Cholesterol 0.3 0.5 1.1 1.0 0.0
Lupus 0.3 0.4 0.5 0.7 0.5
Neuroticism (2016) 1.2 1.7 3.0 -0.7 -1.7
Primary Biliary Cirrhosis 0.5 0.6 1.3 1.1 0.0
Rheumatoid Arthritis 0.1 0.2 0.3 -0.5 0.2
Schizophrenia (2014) 2.2 4.9 9.7 -3.1 0.0
Triglycerides 0.7 1.2 2.4 1.6 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.5 0.0
Ulcerative Colitis 0.2 0.3 0.6 0.8 -0.2
Blood Eosinophil Count 0.6 4.3 7.2 2.7 1.2
Blood Platelet Count 0.7 8.0 12.7 -3.6 1.8
Blood Red Count 0.3 2.9 5.7 0.3 -2.4
Blood White Count 0.3 1.9 3.6 -1.9 -0.4
Heel T-Score 3.4 26.9 48.9 7.0 2.2
BMI 0.1 0.7 0.7 -0.8 -0.9
Height 0.5 9.7 19.4 -0.2 -4.4
Waist Hip Ratio (WHR) 3.6 16.1 31.1 5.6 1.0
Systolic Blood Pressure 1.7 8.3 14.3 3.8 -1.5
Smoking Status 0.3 0.8 1.3 -0.5 -1.1
Allergy or Eczema 3.3 8.6 16.7 -4.1 -0.7
Cardiovascular Disease 2.2 7.3 12.0 3.5 -1.6
Hypothyroidism (self reported) 0.2 0.5 0.7 -0.8 0.5
Respiratory disease 1.1 2.5 4.7 -2.2 -0.5
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.4 1.2 -0.3
Lung FEV1/FVC ratio 0.0 0.0 0.0 0.0 0.1
Lung FVC 0.3 1.3 1.3 1.1 -1.1
Neuroticism 0.1 0.3 0.4 -0.6 -0.4
Chronotype (morning person) 0.0 0.1 0.2 -0.0 0.5
Hair Pigment 0.0 0.9 1.3 1.1 -0.7
Tanning 0.3 4.1 6.1 1.5 2.5
Hand grip strength (left) 0.4 1.0 2.0 -1.4 -0.0
Number of treatments/medications taken 2.0 3.5 4.9 1.5 -2.2
Average weekly spirits intake 0.7 0.8 1.6 -1.3 -0.3
Sensitivity / hurt feelings 1.6 2.8 4.0 -2.0 -1.2
Frequency of depressed mood in last 2 weeks 1.3 1.8 3.6 -1.9 -0.2
Hearing difficulty/problems: Yes 0.0 0.1 0.1 0.3 0.3
Relative age of first facial hair 0.2 0.5 0.5 -0.7 -0.7
Other serious medical condition/disability diagnosed by doctor 1.3 1.6 3.2 -0.3 -1.8
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.8 -1.4 0.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 -0.4 0.1
Systolic blood pressure, automated reading 2.2 6.5 10.4 3.2 -1.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.7 0.5 -0.8
Angina 2.3 3.0 6.0 2.4 0.0
Medication for hormone replacement therapy 2.1 2.4 4.1 -2.0 -0.8
Vitamin and mineral supplements 0.3 0.4 0.4 0.6 0.6
Supplements: Zinc 0.5 0.5 0.9 -1.0 -0.3
Medication: Co-codamol 0.6 0.7 1.2 -1.1 0.5
Medication: Metformin 0.3 0.4 0.7 0.8 0.3
Diabetes (father) 2.2 2.7 5.3 -2.3 0.4
Diabetes (mother) 0.6 0.8 1.2 1.1 -0.6
Severe depression (siblings) 0.0 0.0 0.0 0.1 -0.0
Pack years adult smoking proportion 0.3 0.5 0.9 0.4 -1.0
Impedance of leg (right) 0.0 0.2 0.3 -0.6 0.0
Leg fat-free mass (left) 0.5 2.5 3.1 -1.4 -1.8
Trunk fat percentage 0.6 2.5 3.6 -1.2 -1.9
Hand grip strength (right) 0.2 0.4 0.7 -0.8 -0.4
Townsend deprivation index at recruitment 0.1 0.2 0.2 -0.4 -0.4
Current tobacco smoking 0.6 0.9 1.1 -1.1 -0.8
Average weekly fortified wine intake 0.2 0.3 0.3 -0.5 -0.5
Maternal smoking around birth 0.9 1.3 2.2 0.7 -1.5
Fed-up feelings 1.2 2.2 4.5 -2.1 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.8 -1.4 0.4
Relative age voice broke 0.2 0.3 0.3 -0.6 0.5
Taking other prescription medications 0.7 1.1 2.0 0.4 -1.4
Age when periods started (menarche) 0.3 0.8 1.5 0.2 -1.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 0.9 -0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 5.6 2.4 0.0
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.1 0.0 0.3
Qualifications: CSEs or equivalent 1.6 2.1 4.0 -2.0 0.4
Serious illness, injury or assault to yourself 0.7 0.9 1.1 -0.8 -1.0
High blood pressure 3.2 9.0 13.0 3.6 -2.2
Hayfever, allergic rhinitis or eczema 3.9 8.5 16.3 -4.0 0.8
Multivitamins +/- minerals 0.3 0.4 0.7 -0.8 -0.2
Stomach or abdominal pain in last month 1.3 1.6 2.4 -1.5 -0.9
Supplements: Glucosamine 0.1 0.2 0.3 -0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 3.4 4.0 5.4 -2.3 -1.6
Medication: Atenolol 1.5 1.8 3.7 1.9 -0.1
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.3 0.8
Sitting height 0.9 6.2 7.2 -2.3 -2.7
Chronic bronchitis/emphysema (father) 1.5 1.7 2.5 1.0 -1.6
High blood pressure (mother) 1.6 2.2 2.7 1.3 -1.7
Body mass index (BMI) 0.2 0.9 1.0 -0.9 -1.0
Impedance of leg (left) 0.0 0.0 0.0 -0.1 0.0
Leg predicted mass (left) 0.5 2.5 3.0 -1.4 -1.7
Trunk fat mass 0.7 3.2 5.1 -1.1 -2.2
Waist circumference 0.5 1.9 2.8 1.0 -1.7
Number of incorrect matches in round 0.4 0.7 1.1 1.1 0.6
Past tobacco smoking 0.5 0.9 1.6 -0.5 1.2
Alcohol usually taken with meals 0.1 0.1 0.2 -0.2 -0.4
Nervous feelings 0.6 1.1 1.3 -1.1 0.9
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 3.9 -2.0 2.0
Hearing difficulty/problems with background noise 0.2 0.3 0.5 0.2 0.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.5 -0.1
Had menopause 0.8 0.9 1.0 1.0 -0.9
Had other major operations 0.4 0.5 0.8 -0.9 -0.4
Forced vital capacity (FVC) 0.3 1.2 1.6 -1.3 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.2 3.9 2.0 -0.7
Ever unenthusiastic/disinterested for a whole week 4.1 5.0 9.3 -3.1 0.9
Qualifications: None of the above 0.1 0.1 0.2 0.4 -0.2
Financial difficulties in last 2 years 2.3 3.1 6.2 -2.5 -0.1
Mouth/teeth dental problems 0.3 0.5 0.9 -0.9 -0.4
Heart attack 2.5 3.2 5.3 2.3 1.0
Allergy 3.8 8.6 16.4 4.0 -0.9
Pain all over the body in last month 0.5 0.5 1.0 -1.0 -0.2
Diabetes (self-reported) 0.6 1.0 1.9 0.2 -1.4
Hayfever/allergic rhinitis (self-reported) 3.7 4.8 4.9 -2.2 2.2
Medication: Ramipril 1.6 2.1 4.0 2.0 0.5
Medication: Simvastatin 2.2 3.2 6.3 2.5 -0.2
Fluid intelligence score 0.7 1.4 2.3 0.7 -1.5
Illnesses of siblings 0.4 0.5 0.8 0.5 0.9
Neuroticism score 0.8 1.7 2.3 -1.5 1.0
Weight 0.6 3.2 5.1 -1.1 -2.3
Impedance of arm (right) 0.1 0.3 0.3 -0.6 -0.5
Arm fat percentage (right) 0.5 2.0 2.9 -1.1 -1.7
Trunk fat-free mass 0.4 2.2 3.8 -0.7 -2.0
Hip circumference 1.4 5.9 7.8 -2.8 -2.0
Time employed in main current job 0.3 0.3 0.5 0.3 0.7
Alcohol intake versus 10 years previously 0.7 1.0 1.9 -0.2 -1.4
Father’s age at death 1.5 2.1 2.9 -1.7 -1.1
Worrier / anxious feelings 1.1 2.0 2.3 -1.5 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.0 3.4 -1.8 -1.6
Falls in the last year 0.1 0.1 0.3 -0.5 0.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 -0.8 0.0
Number of live births 0.8 1.2 2.4 1.5 -0.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.5 -0.7 -0.4
Pulse rate 0.7 1.2 2.3 -1.5 -0.2
Happiness 0.2 0.2 0.3 0.6 0.4
Noisy workplace 0.2 0.3 0.3 0.5 0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.9 -1.7 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 2.0 1.3 1.4
Mouth/teeth dental problems: Dentures 0.4 0.6 1.3 0.0 -1.1
Asthma 2.1 4.1 8.2 -2.9 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.5 -1.2 0.6
Medication: Cholesterol lowering 2.5 3.9 7.2 2.7 0.8
Depression (self-reported) 0.7 0.9 1.7 -1.3 0.1
Medication: Lansoprazole 0.1 0.1 0.1 0.3 0.3
Prospective memory result 0.2 0.2 0.3 -0.3 -0.5
Lung cancer (father) 1.9 2.2 3.2 1.1 1.8
Illnesses of mother 0.6 0.7 0.9 -1.0 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.4 -1.2 -0.8
Pulse wave Arterial Stiffness index 0.3 0.4 0.7 0.8 -0.1
Impedance of arm (left) 0.2 0.7 0.9 -0.9 -0.7
Arm fat mass (right) 0.7 2.8 4.6 -1.0 -2.1
Trunk predicted mass 0.4 2.3 4.1 -0.6 -2.0
Standing height 0.5 5.2 9.8 -0.8 -3.1
Length of working week for main job 0.1 0.1 0.1 -0.3 0.4
Exposure to tobacco smoke at home 0.5 0.5 0.9 -0.5 0.9
Breastfed as a baby 0.2 0.2 0.3 0.4 0.5
Tense / ‘highly strung’ 0.1 0.2 0.3 0.5 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 4.6 -2.1 -0.0
Hair/balding pattern: Pattern 4 0.1 0.3 0.5 0.7 -0.3
Birth weight of first child 1.7 3.0 6.0 -2.4 -0.2
Peak expiratory flow (PEF) 0.2 0.6 0.6 -0.8 -0.7
Pulse wave reflection index 0.5 0.6 0.7 0.7 0.9
Ever highly irritable/argumentative for 2 days 0.8 1.0 1.7 -0.5 1.3
Loud music exposure frequency 1.6 1.7 3.1 -0.6 1.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 1.5 -1.0 -1.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 1.7 0.9 1.3
Blood clot in the leg (DVT) 0.4 0.6 1.1 -1.1 -0.0
Medication: Paracetamol 1.3 2.2 2.9 -1.2 -1.7
Headache pain in last month 1.4 2.4 4.6 -2.1 -0.4
Medication for cholesterol, blood pressure or diabetes 3.8 6.3 12.1 -3.5 0.7
Glaucoma (self-reported) 0.4 0.5 0.9 0.3 -1.0
Gout (self-reported) 0.3 0.5 0.6 0.6 -0.8
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 -0.0 0.7
Medication: Amlodipine 0.4 0.5 0.8 0.9 -0.5
Medication: Ventolin 100micrograms inhaler 1.0 1.3 1.5 -1.2 1.1
Birth weight 1.9 4.2 8.4 -2.9 -0.1
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.1 -1.5 -0.8
High blood pressure (siblings) 1.6 2.4 3.4 -1.1 -1.9
Forced vital capacity (FVC), Best measure 0.5 1.8 2.2 -1.5 -1.2
Body fat percentage 0.6 2.3 3.2 -1.2 -1.8
Leg fat percentage (right) 0.3 1.2 1.4 -1.0 -1.2
Arm fat-free mass (right) 0.3 1.6 3.2 -0.3 -1.8
Exposure to tobacco smoke outside home 0.2 0.2 0.5 -0.7 0.0
Comparative body size at age 10 0.0 0.1 0.2 -0.2 0.4
Number of full brothers 1.3 1.6 3.2 -1.8 0.3
Worry too long after embarrassment 0.9 1.5 2.7 -1.6 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 2.0 -1.1 -1.4
Wheeze or whistling in the chest in last year 4.3 7.7 15.4 -3.9 0.2
Number of children fathered 0.9 1.0 2.0 -0.3 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.4 -1.2 0.2
Age at first live birth 2.9 5.1 5.7 2.1 2.4
Pulse wave peak to peak time 0.4 0.5 1.0 -1.0 -0.1
Health satisfaction 0.5 0.6 1.3 -1.1 0.1
Shortness of breath walking on level ground 0.3 0.4 0.4 -0.6 -0.6
Qualifications: College or University degree 0.3 0.9 1.9 0.1 -1.4
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.3 0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.2 0.5 -0.5
Emphysema/chronic bronchitis 2.7 3.0 5.7 0.6 -2.4
Medication for pain relief, constipation, heartburn 0.7 1.3 2.5 0.2 1.6
Neck or shoulder pain in last month 0.6 0.9 1.1 -1.1 0.8
Medication: Blood pressure 4.5 8.0 15.3 3.9 -0.8
Angina (self-reported) 1.5 2.0 4.0 2.0 0.1
Migraine (self-reported) 0.1 0.1 0.1 0.0 -0.4
Medication: Ibuprofen 0.6 0.7 1.3 -1.1 0.4
Medication: Allopurinol 0.2 0.2 0.4 0.6 0.2
Medication: Omeprazole 2.4 2.8 4.9 -0.9 -2.2
Medication: Seretide 50 evohaler 1.2 1.4 2.2 -0.7 -1.5
Mean time to correctly identify matches 1.1 2.0 2.4 1.6 1.3
Heart disease (mother) 0.4 0.5 0.9 1.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.4 -0.4 0.6
Whole body fat mass 0.7 3.0 4.8 -1.1 -2.2
Leg fat mass (right) 0.5 1.9 3.1 -0.9 -1.8
Arm predicted mass (right) 0.3 1.6 2.7 -0.7 -1.6
Pulse rate, automated reading 0.8 2.5 4.8 -2.2 0.3
Alcohol intake frequency. 0.1 0.2 0.4 -0.2 -0.7
Comparative height size at age 10 0.1 0.6 0.7 -0.7 -0.9
Number of full sisters 0.5 0.6 1.2 -1.1 -0.0
Suffer from ‘nerves’ 4.2 6.6 12.5 -3.5 0.8
Overall health rating 0.6 1.2 1.9 -0.8 -1.4
Chest pain or discomfort 0.7 1.0 1.6 -1.2 0.7
Had major operations 2.2 2.6 5.1 2.2 0.3
Age at last live birth 3.2 4.7 7.1 1.5 2.7
Family relationship satisfaction 0.4 0.5 0.8 0.5 -0.9
Leg pain on walking 1.8 2.3 4.5 -0.1 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.8 -0.9 -0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.4 -0.6 -0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.6 1.3 -0.3
Medication: Aspirin 5.8 7.7 14.4 3.8 -0.9
Supplements: Vitamin C 1.1 1.3 2.0 -1.4 -0.8
Knee pain experienced in last month 0.3 0.4 0.7 -0.8 -0.4
Hypertension (Self-reported) 3.2 9.0 13.5 3.7 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 -1.0 0.3
Illnesses of father: Heart disease 2.4 3.3 6.4 2.5 0.5
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.9 -0.5
Smoking status: Previous 0.9 1.4 2.4 1.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 0.9 -0.9 -1.0
Whole body fat-free mass 0.4 2.4 4.0 -0.9 -2.0
Leg fat-free mass (right) 0.4 2.1 3.1 -1.1 -1.8
Arm fat percentage (left) 0.5 1.9 2.6 -1.1 -1.6
Average weekly red wine intake 0.1 0.1 0.2 -0.1 -0.4
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 -0.2 0.0
Mood swings 0.6 1.0 1.1 -1.1 0.9
Loneliness, isolation 0.4 0.6 1.2 -1.1 -0.3
Long-standing illness, disability or infirmity 0.5 0.8 1.5 -0.3 -1.2
Ever had bowel cancer screening 4.3 5.0 7.0 2.6 -1.7
Diabetes diagnosed by doctor 0.5 0.7 1.2 1.1 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.5 1.2 -0.1
Friendships satisfaction 1.7 2.1 2.9 1.2 1.7
Qualifications: nursing, teaching 1.1 1.8 3.5 -1.9 0.2
Commuting to job workplace: Walk 0.8 0.9 1.6 -0.4 -1.3
Eye problems/disorders: Cataract 0.0 0.0 0.0 0.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 3.5 1.9 -0.4
Medication for cholesterol 2.3 3.5 4.7 -1.5 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.0 -0.9 -1.0
Back pain experienced in last month 0.9 1.3 2.6 -1.6 -0.2
Mineral and other dietary supplements 1.8 2.5 4.5 -0.6 2.1
Breast cancer (self-reported) 1.7 2.0 2.8 -1.1 -1.7
Asthma (self-reported) 1.6 3.3 6.5 -2.5 -0.1
Osteoporosis (self-reported) 1.5 1.9 3.0 -1.7 -0.9
Osteoarthritis (self-reported) 1.3 1.7 3.3 -1.8 0.2
Medication: Aspirin 5.7 7.4 14.0 3.7 -0.9
Medication: Gliclazide 0.9 1.1 1.9 1.4 0.4
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 -0.1 0.3
Smoking status: Current 0.8 1.3 1.6 -1.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.0 0.4 1.0
Whole body water mass 0.4 2.4 3.9 -0.9 -2.0
Leg predicted mass (right) 0.4 2.2 3.2 -1.1 -1.8
Arm fat mass (left) 0.7 2.7 4.4 -1.1 -2.1
Number of self-reported non-cancer illnesses 1.0 1.7 3.3 0.2 -1.8
Average weekly champagne plus white wine intake 0.5 0.7 0.8 0.7 0.9
Miserableness 0.4 0.8 1.4 -1.2 -0.3
Guilty feelings 0.0 0.0 0.0 0.1 -0.0
Wears glasses or contact lenses 1.3 1.5 2.3 0.8 1.5
Ever taken oral contraceptive pill 0.7 0.7 1.1 -0.6 1.1
Hearing aid user 0.3 0.4 0.7 0.8 -0.3
Mother’s age at death 0.9 1.2 2.0 1.4 -0.6
Financial situation satisfaction 2.3 2.9 3.7 -1.4 -1.9
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.8 -0.1 0.9
Commuting to job workplace: Public transport 0.6 0.7 1.5 0.1 1.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.3 -0.6 -0.6
Medication: Blood pressure 3.7 7.0 13.2 3.6 -0.9
Pain type(s) experienced in last month: Hip pain 2.6 3.2 6.0 -2.4 0.7
Supplements: Fish oil (including cod liver oil) 1.4 1.9 3.6 0.4 -1.9
High cholesterol (Self-reported) 2.1 3.8 7.0 2.6 -0.8
Medication: Bendroflumethiazide 3.0 4.5 8.1 2.8 1.0
Medication: Paracetamol 1.7 2.6 4.7 -0.7 -2.2
Medication: Lisinopril 3.5 4.5 9.0 3.0 -0.2
Medication: Atorvastatin 1.0 1.3 2.5 -0.3 1.6
Illnesses of father: High blood pressure 0.6 0.7 0.8 -0.8 0.9
Alcohol drinker status: Never 1.9 2.2 4.2 -2.0 -0.5
Ever smoked 0.6 1.0 1.7 -0.6 -1.3
Basal metabolic rate 0.5 2.9 4.5 -1.1 -2.1
Leg fat percentage (left) 0.3 1.2 1.7 -0.8 -1.3
Arm fat-free mass (left) 0.3 1.4 2.7 -0.4 -1.6
Number of operations (self-reported) 0.2 0.2 0.5 -0.1 -0.7
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.0 -0.6
Irritability 0.9 1.6 3.0 -0.3 1.7
Risk taking 0.3 0.5 0.8 -0.3 -0.9
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.1 1.0 0.2
Fractured/broken bones in last 5 years 0.4 0.5 0.6 -0.8 0.7
Age started oral contraceptive pill 0.3 0.3 0.5 0.7 -0.3
Diastolic blood pressure, automated reading 0.6 1.9 3.0 0.9 -1.7
Ever depressed for a whole week 2.1 2.6 5.2 -2.3 -0.3
Unable to work because of sickness or disability 2.1 2.7 5.2 -0.4 -2.3
Commuting to job workplace: Cycle 1.4 1.7 2.2 1.5 -1.1
Myopia 3.8 5.4 9.7 3.1 1.1
Vascular/heart problems diagnosed by doctor 4.2 11.4 20.1 -4.5 1.7
Cholesterol lowering medication 0.7 1.1 1.8 1.3 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 3.1 -0.7 -1.8
Pain experienced in last month 0.5 0.9 1.7 1.3 -0.4
Supplements: Calcium 3.0 3.3 4.9 -1.3 -2.2
Basal cell carcinoma (self-reported) 0.6 0.7 1.3 1.2 0.2
Heart attack/myocardial infarction (self-reported) 2.3 3.0 5.3 2.3 0.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.3 -1.1 0.1
Heart disease (siblings) 0.7 0.8 1.1 1.0 -0.7
Alcohol drinker status: Previous 0.2 0.2 0.3 0.6 0.4
Pack years of smoking 0.6 0.9 1.3 1.1 -0.8
Impedance of whole body 0.1 0.3 0.5 -0.7 -0.2
Leg fat mass (left) 0.5 1.8 3.2 -0.7 -1.8
Arm predicted mass (left) 0.4 1.9 3.5 -0.6 -1.9