[Hub]/) : Traits : Heel T-Score :

chr1:169,802,760-174,525,917

Best TWAS P=9.75e-17 · Best GWAS P=2.69e-47 conditioned to 1.62e-10

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FMO4 0.07 0.00 blup 610 0.02 1.7e-03 -0.99 5.6 1.8e-08 -0.04 0.31 0.15 FALSE
2 GTEx Adipose Visceral Omentum FMO3 0.14 0.15 lasso 3 0.13 1.9e-07 -5.78 -5.3 1.0e-07 0.10 0.91 0.01 FALSE
3 GTEx Brain Caudate basal ganglia DARS2 0.19 0.02 lasso 5 0.13 1.2e-04 -6.86 6.8 1.0e-11 0.02 0.07 0.66 TRUE
4 GTEx Breast Mammary Tissue (Male) SUCO 0.15 -0.01 lasso 1 0.01 2.3e-01 -5.52 5.2 1.9e-07 -0.10 0.04 0.05 FALSE
5 GTEx Breast Mammary Tissue (Female) SUCO 0.33 0.00 lasso 9 0.01 1.8e-01 -4.71 5.2 2.6e-07 -0.17 0.08 0.07 FALSE
6 GTEx Cells Transformed fibroblasts PIGC 0.12 0.00 enet 29 0.04 2.7e-04 10.64 -7.7 1.6e-14 0.48 0.08 0.06 TRUE
7 GTEx Colon Transverse SUCO 0.22 0.02 enet 30 0.08 1.7e-04 3.23 6.8 1.4e-11 -0.20 0.25 0.11 TRUE
8 GTEx Pancreas SUCO 0.17 0.00 enet 15 0.07 5.6e-04 -7.07 5.4 6.7e-08 -0.18 0.12 0.04 FALSE
9 GTEx Skin Sun Exposed Lower leg GORAB 0.07 0.01 lasso 5 0.00 4.2e-01 2.56 7.8 8.5e-15 -0.04 0.08 0.12 TRUE
10 GTEx Skin Sun Exposed Lower leg PIGC 0.08 0.02 lasso 5 0.02 8.8e-03 -7.74 -7.0 3.3e-12 0.22 0.52 0.03 FALSE
11 GTEx Spleen PIGC 0.29 0.04 lasso 6 0.07 6.6e-03 5.68 5.9 3.5e-09 -0.26 0.07 0.06 FALSE
12 GTEx Testis PIGC 0.25 0.17 lasso 2 0.15 4.2e-07 6.23 6.2 4.7e-10 -0.36 0.97 0.00 FALSE
13 GTEx Thyroid FMO3 0.13 0.05 lasso 12 0.04 9.6e-04 -5.60 -6.7 2.3e-11 0.10 0.99 0.00 FALSE
14 GTEx Thyroid FMO2 0.23 0.03 enet 47 0.06 2.0e-05 -3.41 -8.3 9.7e-17 0.12 0.63 0.08 TRUE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PIGC 0.02 0.03 enet 3 0.02 1.3e-03 6.15 -7.4 1.3e-13 0.35 0.09 0.16 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PIGC 0.10 0.01 blup 94 0.05 1.0e-06 4.24 -7.6 3.7e-14 0.34 0.12 0.08 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma ANKRD45 0.14 0.01 lasso 4 0.07 6.9e-08 -5.09 -6.3 3.7e-10 0.00 0.00 0.80 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma PIGC 0.09 0.00 blup 94 0.04 2.9e-05 4.08 -7.7 1.5e-14 0.28 0.05 0.31 FALSE
19 The Cancer Genome Atlas Lung Adenocarcinoma PIGC 0.04 0.00 blup 94 0.01 3.2e-02 7.09 -5.9 3.1e-09 0.38 0.25 0.03 FALSE
20 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FMO3 0.05 0.02 blup 100 0.02 8.6e-03 -6.07 -5.7 1.5e-08 0.08 0.02 0.91 FALSE
21 The Cancer Genome Atlas Pancreatic Adenocarcinoma C1orf105 0.13 -0.01 blup 100 0.03 1.5e-02 -7.07 -7.0 2.9e-12 0.34 0.03 0.36 FALSE
22 The Cancer Genome Atlas Pancreatic Adenocarcinoma FMO3 0.10 0.10 blup 99 0.10 4.1e-05 -4.82 -5.6 2.1e-08 0.09 0.03 0.97 FALSE
23 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PIGC 0.16 0.06 blup 94 0.07 6.9e-04 -7.96 7.8 4.8e-15 -0.26 0.01 0.93 TRUE
24 The Cancer Genome Atlas Testicular Germ Cell Tumors RC3H1 0.13 -0.01 blup 58 0.01 1.4e-01 2.50 5.6 2.4e-08 -0.07 0.01 0.29 FALSE
25 The Cancer Genome Atlas Thyroid Carcinoma DNM3 0.13 0.08 enet 29 0.10 4.9e-10 -4.79 -6.8 1.0e-11 0.36 1.00 0.00 TRUE
26 The Cancer Genome Atlas Thyroid Carcinoma PIGC 0.09 0.02 blup 94 0.05 5.2e-06 4.21 -6.1 1.1e-09 0.27 0.18 0.10 FALSE