Hub : Genes

DNM3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.3470 0.0900 1.3e-04 0.256 NA 0.277 NA 0.263 3.0e-07 NA 8.3e-08 NA 1.9e-07
2 GTEx Brain Cerebellum 0.2640 0.0840 1.2e-03 0.289 NA 0.249 NA 0.274 3.4e-09 NA 5.7e-08 NA 1.0e-08
3 GTEx Skin Not Sun Exposed Suprapubic 0.1720 0.0540 3.2e-04 0.122 NA 0.089 NA 0.104 3.5e-07 NA 1.4e-05 NA 2.6e-06
4 GTEx Skin Sun Exposed Lower leg 0.1320 0.0390 9.4e-05 0.086 NA 0.076 NA 0.074 1.4e-07 NA 7.7e-07 NA 9.6e-07
5 YFS Blood 0.0333 0.0133 1.8e-03 0.004 0.010 0.010 0.013 0.007 1.3e-02 1.7e-04 2.6e-04 4e-05 1.7e-03
6 TCGA Kidney Renal Papillary Cell Carcinoma 0.2430 0.0660 2.2e-07 0.152 0.147 0.177 NA 0.172 4.7e-09 9.1e-09 2.4e-10 NA 4.4e-10
7 TCGA Prostate Adenocarcinoma 0.0488 0.0201 2.6e-04 0.029 0.034 0.037 NA 0.034 4.4e-04 1.7e-04 8.8e-05 NA 1.7e-04
8 TCGA Thyroid Carcinoma 0.1330 0.0370 3.8e-09 0.079 0.097 0.101 NA 0.080 4.3e-08 1.0e-09 4.9e-10 NA 3.5e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.5 0.7 1.7 0.8 1.0 -0.7 -0.5 1.3 0.2 -1.3 0.5
Bipolar Disorder or Schizophrenia 0.3 0.8 2.2 -1.0 -0.4 -1.5 -1.4 0.9 -0.0 0.0 0.0
Depressed Affect (Nagel 2018) 2.3 4.9 8.4 -2.5 -2.5 -2.8 -2.9 -1.5 1.9 1.9 0.9
Depression (Nagel 2018) 0.8 1.2 3.2 -0.5 -0.9 -1.8 -1.7 -1.6 0.1 -0.4 -0.4
Intelligence (Savage-Jansen 2018) 2.0 6.0 23.5 0.9 0.7 4.7 4.8 0.7 0.1 0.5 0.5
Neuroticism (Nagel 2018) 2.9 6.8 14.4 -2.4 -2.5 -3.5 -3.8 -1.5 3.1 1.2 1.6
Schizophrenia (2018) 0.7 1.4 4.3 -2.1 -1.4 -1.4 -1.5 0.1 -0.2 1.1 -0.3
Schizophrenia vs Biploar Disorder 0.6 0.7 1.4 -1.0 -0.2 -1.2 -1.1 -1.1 -0.4 -0.0 -0.9
Worry (Nagel 2018) 2.9 6.2 12.0 -2.6 -2.7 -3.1 -3.5 -0.9 2.7 1.6 1.8
Alzheimer’s Disease (in mother) 1.0 1.2 3.5 1.9 1.2 1.4 1.0 -0.4 0.3 -0.8 0.7
Alzheimer’s Disease (in father) 0.1 0.2 0.3 -0.3 0.2 0.5 0.4 -0.5 0.0 -0.5 -0.5
Alzheimer’s Disease (including proxy) 0.9 1.2 2.6 1.3 1.1 1.6 1.3 -0.9 0.2 -1.4 -0.0
Crohns Disease (2017) 0.3 0.7 3.0 0.5 0.0 1.0 0.5 -0.2 1.7 0.0 1.1
Irritable Bowel Disease (IBD) 0.3 0.8 3.2 -0.4 -1.0 0.2 -0.1 0.4 1.8 1.2 0.7
Ulcerative Colitis (UC) 0.7 1.4 3.2 -1.2 -1.8 -0.5 -0.6 0.9 1.3 1.7 0.4
Major Depression (MDD) 0.7 0.8 2.9 -0.6 -1.7 -0.4 -0.2 -1.0 0.3 1.4 0.4
Reaction Time 0.3 0.6 2.4 0.5 -0.0 -0.5 -0.3 -0.3 1.6 -0.9 0.9
Verbal and Numeric Reasoning (VNR) 2.6 6.2 25.1 0.7 0.4 4.8 5.0 0.5 -0.3 0.8 0.6
Breast Cancer 0.7 1.6 4.5 -0.8 -1.6 0.6 0.1 -0.6 1.7 2.1 1.2
Ovarian Cancer 2.5 3.3 6.6 -1.8 -1.3 -2.6 -2.5 2.0 1.0 0.8 1.7
Prostate Cancer 0.8 1.1 2.8 -0.0 -0.1 1.4 1.4 1.7 -0.2 0.8 1.0
Age at First Birth 0.2 0.3 0.9 -0.2 0.4 -0.7 -0.9 0.5 0.4 -0.6 -0.3
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.4 0.5 -0.3 -0.2 -0.4 -0.0 -0.8 -0.2
Body Mass Index (BMI) (2010) 0.7 1.0 2.2 0.9 1.3 1.3 1.5 -0.0 -1.2 -0.3 0.2
Coronary Artery Disease (CAD) 0.4 0.5 1.6 -0.4 -0.4 -0.3 -0.2 -1.3 -0.2 1.3 -0.5
Crohns Disease (2012) 0.1 0.2 0.6 -0.3 -0.4 -0.1 -0.5 -0.0 0.8 0.3 0.8
Mean Putamen Volume 0.8 0.9 3.8 0.3 0.0 -2.0 -1.7 0.5 0.1 -0.4 -0.3
Fasting Glucose 0.4 0.5 2.5 0.2 0.3 -0.3 -0.4 -0.1 -1.6 0.3 -0.9
HbA1C 1.6 1.8 6.4 -0.6 -1.1 -0.1 -0.2 0.6 1.4 1.9 2.5
HDL Cholesterol 0.9 1.5 2.3 0.9 1.2 1.4 1.4 1.4 -1.1 -1.5 0.1
LDL Cholesterol 0.4 0.6 1.3 0.9 0.7 1.1 1.1 0.8 0.4 0.6 0.0
Lupus 0.6 0.9 2.6 -0.5 -0.6 -0.6 -0.8 -0.9 -1.5 -0.1 -1.6
Neuroticism (2016) 2.3 3.4 6.0 -2.0 -2.4 -1.6 -2.0 -1.0 2.3 1.5 1.3
Primary Biliary Cirrhosis 1.1 1.6 2.5 1.4 1.2 1.4 1.6 0.8 -1.1 -1.5 -0.8
Rheumatoid Arthritis 0.8 1.1 2.9 1.4 1.3 -1.0 -0.5 0.3 -0.4 -1.7 -0.7
Schizophrenia (2014) 0.5 1.1 3.3 -1.1 -0.5 -1.8 -1.8 0.6 -0.1 -0.2 -0.8
Triglycerides 0.5 0.9 2.2 -0.5 -0.9 -0.7 -0.6 -1.0 1.5 1.3 0.7
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.6 0.2 -0.2 0.1 0.5 -0.5 0.0 0.8 -0.1
Ulcerative Colitis 0.2 0.2 1.4 0.0 -0.1 -0.4 -0.2 1.2 -0.2 0.2 -0.4
Blood Eosinophil Count 0.1 0.9 2.9 0.0 -0.3 0.9 1.7 1.0 -0.9 0.6 -1.1
Blood Platelet Count 8.2 95.3 231.0 15.2 14.8 9.6 9.4 5.1 -3.2 -9.7 1.5
Blood Red Count 0.7 7.0 15.4 -1.6 -2.1 -3.5 -3.8 -3.9 1.5 2.1 -0.2
Blood White Count 0.0 0.2 0.6 0.1 0.2 -0.2 -0.1 -0.8 -0.5 0.6 -0.4
Heel T-Score 1.9 14.9 46.2 -0.1 1.1 -1.8 -1.3 -4.7 -4.7 -4.8 -6.8
BMI 0.8 4.5 11.5 -2.2 -2.7 -0.3 -0.6 0.5 2.5 2.3 3.4
Height 0.9 16.4 39.6 -3.9 -5.0 3.8 3.2 -0.0 -4.5 2.3 -6.3
Waist Hip Ratio (WHR) 0.5 2.3 7.8 -0.3 -1.7 -0.7 -1.2 -0.8 2.8 1.8 1.3
Systolic Blood Pressure 0.5 2.4 6.1 1.9 0.4 2.5 2.3 0.7 -1.3 0.5 -1.2
Smoking Status 1.8 4.3 7.9 -2.8 -2.3 -1.1 -1.3 -1.7 2.2 2.7 1.9
Allergy or Eczema 1.1 3.0 5.8 1.6 1.6 1.6 1.9 -1.6 -1.7 -1.1 -2.4
Cardiovascular Disease 0.3 1.0 2.7 -0.1 -1.4 1.6 1.1 -0.8 -0.0 1.2 -0.1
Hypothyroidism (self reported) 0.4 0.8 3.0 0.2 -0.1 -1.5 -1.7 0.0 -0.1 -1.1 -0.1
Respiratory disease 0.2 0.3 1.1 0.6 -0.5 0.7 0.3 -1.1 0.1 0.7 -0.2
Type 2 Diabetes (T2D) (2018) 1.4 2.6 6.9 2.3 1.6 0.8 0.6 -0.0 -1.2 -2.6 -1.8
Lung FEV1/FVC ratio 0.9 4.6 8.5 -1.8 -1.9 2.3 1.5 0.2 2.9 2.9 2.2
Lung FVC 0.7 3.4 15.5 0.6 1.4 0.0 0.6 -3.9 -1.6 -2.2 -1.2
Neuroticism 4.5 10.8 24.4 -3.4 -3.2 -4.6 -4.9 -1.1 3.7 1.1 1.7
Chronotype (morning person) 1.5 3.4 7.9 -1.1 -1.4 -0.6 -1.4 1.4 2.8 2.3 2.6
Hair Pigment 0.0 1.2 3.0 1.5 0.7 -1.7 -1.4 -0.9 0.5 -0.6 -0.8
Tanning 0.1 1.6 2.7 -1.4 -1.6 -0.9 -1.1 -0.9 1.1 1.4 1.6
Hand grip strength (left) 0.1 0.3 0.7 0.4 -0.3 0.6 0.9 0.7 -0.4 -0.3 -0.5
Number of treatments/medications taken 0.3 0.5 2.9 0.9 0.5 0.5 0.1 -1.7 -0.0 -0.2 -0.4
Average weekly spirits intake 1.3 1.6 3.0 -1.4 -1.7 -0.8 -1.2 -1.0 1.7 1.1 0.9
Sensitivity / hurt feelings 2.7 4.6 11.7 -1.1 -1.7 -3.1 -3.2 -0.7 3.4 0.8 0.3
Frequency of depressed mood in last 2 weeks 0.8 1.1 1.6 -1.3 -1.2 -1.0 -1.1 -1.2 1.2 0.4 0.4
Hearing difficulty/problems: Yes 0.4 0.6 1.8 0.5 0.2 -0.9 -1.3 -0.0 -0.3 -1.1 -0.6
Relative age of first facial hair 0.5 1.1 3.5 1.2 1.0 1.0 0.6 1.9 0.4 -1.1 -0.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 4.7 0.6 0.4 1.2 1.0 -0.5 -2.2 -0.6 -0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.4 0.5 0.0 -0.3 -0.2 0.3 -1.2 0.3 -0.3
Ever had hysterectomy (womb removed) 0.2 0.2 0.7 -0.6 -0.4 -0.5 -0.8 -0.0 -0.3 -0.5 -0.4
Systolic blood pressure, automated reading 0.1 0.4 1.6 0.3 -0.0 0.7 0.2 0.2 -1.3 0.0 -1.0
Eye problems/disorders: Diabetes related eye disease 3.3 3.6 7.8 2.7 2.7 0.3 0.7 -1.8 -0.8 -2.8 -1.5
Angina 0.3 0.4 2.4 0.2 0.0 0.4 -0.4 -1.6 0.2 0.0 0.2
Medication for hormone replacement therapy 0.3 0.3 1.5 -0.4 -0.4 -0.5 -0.1 -0.5 -1.2 0.2 -0.3
Vitamin and mineral supplements 0.3 0.5 1.2 1.1 0.4 0.6 1.1 0.7 0.3 0.0 0.4
Supplements: Zinc 3.3 3.6 8.8 -2.3 -2.4 0.1 -0.4 1.0 2.2 3.0 1.8
Medication: Co-codamol 1.0 1.1 3.3 -0.4 -0.6 -1.6 -1.8 -1.4 0.7 -0.5 0.3
Medication: Metformin 1.1 1.5 3.0 1.7 1.1 1.4 1.1 -0.4 -0.9 -1.2 -1.6
Diabetes (father) 0.6 0.8 1.9 0.9 0.8 -0.9 -0.5 -0.3 -0.9 -0.9 -1.4
Diabetes (mother) 0.3 0.4 1.0 0.6 0.5 -0.7 -0.5 0.2 1.0 -1.0 0.2
Severe depression (siblings) 0.7 0.8 2.2 -0.7 -1.0 -1.0 -1.2 1.5 0.1 0.8 0.3
Pack years adult smoking proportion 0.4 0.6 1.8 -0.8 -1.3 -0.1 -0.8 -0.5 0.4 1.0 0.2
Impedance of leg (right) 0.4 1.9 9.9 0.2 -0.1 -1.1 -1.2 -0.9 -1.0 -0.7 -3.1
Leg fat-free mass (left) 0.4 2.3 6.9 -2.5 -2.6 1.2 1.0 0.3 0.6 1.6 0.5
Trunk fat percentage 0.7 2.6 5.9 -2.1 -2.4 -1.0 -1.2 0.1 1.5 1.8 1.7
Hand grip strength (right) 0.2 0.6 2.3 0.6 -0.2 1.3 1.5 0.3 -0.3 -0.1 -0.2
Townsend deprivation index at recruitment 1.0 1.5 2.8 -1.1 -1.7 -0.4 -0.9 -1.1 1.3 1.2 1.6
Current tobacco smoking 1.1 1.8 3.6 -1.7 -1.2 -0.0 -0.2 -0.9 1.9 1.6 1.8
Average weekly fortified wine intake 0.6 0.7 1.6 0.5 0.7 -0.4 -0.7 0.9 -1.3 -1.2 -0.8
Maternal smoking around birth 1.1 1.5 5.2 -0.5 -0.6 -2.3 -2.2 -0.1 0.7 -0.0 0.9
Fed-up feelings 3.7 6.8 11.4 -3.4 -3.4 -2.1 -2.4 -1.2 3.4 2.5 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 4.7 -1.6 -1.9 -2.1 -2.2 -1.3 0.2 0.8 -1.0
Relative age voice broke 0.7 1.0 2.5 1.2 1.6 1.0 1.1 0.9 0.1 -1.0 0.1
Taking other prescription medications 0.7 1.1 2.2 1.4 0.8 -0.1 -0.1 -1.5 -0.9 -1.2 -1.3
Age when periods started (menarche) 0.6 1.4 4.5 1.0 0.6 2.1 2.1 -0.4 -0.5 -0.1 -0.5
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.2 0.1 0.1 -0.4 -0.2 -0.0 -0.4 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 4.8 -0.8 -0.2 -1.9 -1.5 -0.8 -1.1 -0.9 -2.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -0.2 0.4 -0.6 -0.8 -0.8 1.0 -0.3 0.5
Qualifications: CSEs or equivalent 0.5 0.7 2.4 -0.0 -0.2 -0.3 -0.8 0.6 1.5 0.3 1.4
Serious illness, injury or assault to yourself 0.4 0.4 1.4 -0.9 -0.8 -0.2 -0.5 -1.2 -0.3 0.2 0.2
High blood pressure 0.2 0.5 1.5 0.1 -0.6 0.6 0.3 -1.2 -0.8 0.7 -0.3
Hayfever, allergic rhinitis or eczema 0.6 1.3 4.2 0.7 0.6 1.2 1.4 -0.4 -1.4 -0.4 -2.0
Multivitamins +/- minerals 1.0 1.3 2.7 -1.6 -1.4 -1.2 -1.7 -0.3 -0.4 0.9 -0.7
Stomach or abdominal pain in last month 0.2 0.3 1.1 -0.4 -0.5 -0.5 -0.3 0.2 1.0 0.2 0.5
Supplements: Glucosamine 0.1 0.1 0.7 -0.3 -0.1 -0.2 -0.3 -0.8 -0.2 0.2 0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.3 0.8 -0.1 1.0 0.8 -0.2 -1.1 0.0 -0.5
Medication: Atenolol 0.5 0.6 1.4 0.5 -0.3 1.1 0.6 1.1 0.1 1.2 0.5
Medication: Levothyroxine sodium 1.1 1.8 5.2 1.6 1.6 -0.7 -1.2 0.2 -0.8 -2.3 -1.3
Sitting height 0.6 4.0 10.6 -2.5 -3.2 1.5 1.0 0.8 -1.3 1.4 -2.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 -0.1 0.2 0.4 -0.3 0.5 0.2 -0.4 0.7
High blood pressure (mother) 0.5 0.6 1.3 1.1 0.7 0.3 0.5 -0.2 -0.8 -1.1 -1.1
Body mass index (BMI) 0.9 3.7 8.0 -2.1 -2.2 -1.1 -1.4 -0.4 2.3 2.1 2.8
Impedance of leg (left) 0.4 1.8 8.0 0.2 -0.1 -1.5 -1.5 -0.5 -1.0 -0.6 -2.8
Leg predicted mass (left) 0.5 2.4 7.2 -2.5 -2.7 1.2 1.0 0.3 0.6 1.6 0.5
Trunk fat mass 0.7 3.1 9.0 -2.6 -3.0 -0.6 -0.9 -0.1 1.3 2.1 1.3
Waist circumference 1.2 4.3 8.3 -2.5 -2.9 -0.9 -1.1 -0.7 2.4 2.4 2.3
Number of incorrect matches in round 0.4 0.7 2.4 0.4 0.4 -1.4 -0.5 -0.4 -0.6 -1.5 0.5
Past tobacco smoking 0.7 1.2 4.9 0.6 0.4 1.4 1.2 2.2 -0.7 -0.5 -0.3
Alcohol usually taken with meals 1.2 1.9 3.2 1.2 1.8 0.8 1.3 1.4 -1.6 -1.5 -1.4
Nervous feelings 1.3 2.5 5.8 -1.2 -1.2 -2.2 -2.4 -1.7 1.8 0.2 0.1
Frequency of tenseness / restlessness in last 2 weeks 3.3 5.2 14.3 -2.7 -2.5 -3.3 -3.8 -0.9 0.4 0.8 -0.8
Hearing difficulty/problems with background noise 0.6 1.0 2.6 -1.1 -1.3 -1.1 -1.6 -0.0 1.2 0.1 0.3
Hair/balding pattern: Pattern 2 0.6 0.7 2.7 0.8 1.2 -0.8 -0.4 0.0 -0.2 -1.6 0.4
Had menopause 0.2 0.3 1.0 -1.0 -0.4 -0.3 -0.7 0.3 0.2 0.2 0.7
Had other major operations 0.1 0.2 0.5 -0.2 -0.5 -0.7 -0.4 -0.4 -0.4 0.0 -0.3
Forced vital capacity (FVC) 0.7 2.7 8.1 -0.8 -0.6 1.3 1.7 -1.7 -2.1 -0.6 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.2 5.1 -0.5 0.1 -1.9 -1.5 -1.5 -1.4 -1.4 -2.2
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 4.7 0.4 0.1 -0.2 -0.1 -2.2 -1.6 -0.0 -1.8
Qualifications: None of the above 1.3 2.8 7.7 -1.3 -1.3 -1.1 -1.6 0.4 2.8 1.1 2.4
Financial difficulties in last 2 years 1.4 1.9 6.1 -2.1 -2.5 -0.2 -0.6 -1.0 0.7 1.6 0.8
Mouth/teeth dental problems 1.4 2.1 5.5 -0.7 -1.4 -0.2 -0.7 1.9 2.4 1.2 1.7
Heart attack 0.6 0.8 2.1 -0.3 -1.2 1.1 0.8 0.4 0.9 1.4 0.2
Allergy 0.2 0.4 0.8 -0.4 -0.2 -0.9 -0.8 -0.2 0.7 -0.0 0.8
Pain all over the body in last month 4.2 4.5 10.1 -2.3 -2.5 1.3 0.8 -0.4 2.1 2.8 3.2
Diabetes (self-reported) 2.3 3.6 6.9 2.5 2.0 0.8 0.7 -1.2 -1.8 -2.6 -2.4
Hayfever/allergic rhinitis (self-reported) 2.6 3.4 9.9 1.4 1.5 2.4 3.1 -0.9 -1.8 -1.2 -1.5
Medication: Ramipril 1.3 1.7 4.0 1.7 1.2 1.9 2.0 0.4 -0.7 -0.8 -0.0
Medication: Simvastatin 1.1 1.6 3.5 1.6 1.3 1.0 0.6 -1.9 -1.1 -0.8 -1.4
Fluid intelligence score 2.4 5.0 18.4 0.7 0.6 4.3 4.2 0.9 0.4 0.8 1.2
Illnesses of siblings 0.4 0.6 1.4 0.7 1.2 -0.3 0.1 -0.1 -1.0 -1.1 -0.7
Neuroticism score 5.5 11.4 21.6 -3.8 -3.7 -4.2 -4.6 -1.1 4.1 1.9 1.7
Weight 0.7 3.3 10.6 -2.9 -3.3 0.4 -0.0 -0.2 1.1 2.3 0.9
Impedance of arm (right) 0.5 2.1 3.8 1.5 1.5 0.8 1.2 -0.1 -2.0 -1.6 -2.0
Arm fat percentage (right) 0.8 3.0 6.7 -1.8 -2.1 -1.0 -1.2 -0.1 1.8 2.0 2.6
Trunk fat-free mass 0.4 2.5 7.7 -2.6 -2.8 1.3 0.8 0.3 0.1 1.6 -0.9
Hip circumference 0.5 2.0 6.8 -2.6 -2.2 0.3 0.2 -0.5 0.4 1.6 1.1
Time employed in main current job 0.8 0.9 3.3 0.7 0.3 0.8 0.7 -0.7 1.8 0.4 1.3
Alcohol intake versus 10 years previously 1.1 1.7 6.4 -0.8 -0.8 -1.0 -0.9 -2.5 -0.8 1.2 -1.4
Father’s age at death 0.7 0.9 1.5 0.7 1.1 0.7 1.2 -0.6 -1.2 -1.2 -0.7
Worrier / anxious feelings 4.1 7.7 17.4 -2.8 -3.1 -4.2 -4.1 -0.4 2.3 1.8 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.8 -0.8 -0.9 -1.2 -1.3 -0.9 0.6 0.2 0.1
Falls in the last year 4.1 5.6 10.0 -1.9 -2.5 1.7 0.9 2.3 2.6 3.2 3.0
Hair/balding pattern: Pattern 3 0.3 0.4 1.5 -0.3 -0.7 0.1 -0.4 -0.7 -0.6 1.2 -0.2
Number of live births 1.7 2.4 6.3 1.2 1.5 -0.5 -0.3 -2.5 -1.2 -1.9 -2.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 6.1 -1.0 -1.0 1.5 1.8 -1.9 -1.5 -0.0 -2.5
Pulse rate 1.8 3.1 6.2 1.8 2.5 1.5 1.8 -1.9 -1.5 -1.7 -1.1
Happiness 1.9 2.3 3.5 -1.8 -1.9 -1.8 -1.6 -0.2 1.4 1.6 1.1
Noisy workplace 1.6 2.0 6.9 -1.0 -0.7 -2.6 -2.3 -0.0 1.3 -0.0 0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.4 -0.7 -0.2 1.7 1.8 0.1 -1.3 0.5 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.5 0.5 1.0 0.0 0.3 -1.6 -1.1 -1.6 -1.5
Mouth/teeth dental problems: Dentures 4.1 6.9 19.0 1.6 2.3 -0.2 0.3 -4.4 -3.3 -2.3 -3.4
Asthma 0.3 0.6 1.8 0.3 -0.6 1.3 0.9 -0.6 0.6 0.9 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.7 0.1 0.1 0.3 0.0 -0.6 0.6 -0.8 -0.0
Medication: Cholesterol lowering 0.1 0.2 0.4 -0.2 -0.3 -0.1 -0.5 -0.4 0.7 0.6 0.5
Depression (self-reported) 3.8 4.5 10.4 -3.0 -3.2 -1.6 -1.6 0.9 1.9 2.6 0.8
Medication: Lansoprazole 2.2 2.5 6.0 1.9 2.0 1.3 1.5 -2.5 -0.7 -1.2 0.2
Prospective memory result 1.8 2.2 6.1 -1.8 -1.0 -2.5 -2.4 0.4 -0.2 0.0 0.9
Lung cancer (father) 0.4 0.5 0.9 0.2 0.3 -0.9 -0.8 0.2 -0.8 -0.9 -0.9
Illnesses of mother 1.0 1.3 3.9 -1.7 -1.6 -0.1 -0.3 -0.8 0.1 2.0 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 5.9 -0.7 -0.6 1.3 1.6 -1.5 -1.4 -0.7 -2.4
Pulse wave Arterial Stiffness index 0.2 0.3 1.1 0.5 0.3 1.1 0.6 -0.5 -0.3 -0.1 0.3
Impedance of arm (left) 0.5 2.3 3.3 1.4 1.5 1.4 1.7 -0.1 -1.8 -1.5 -1.8
Arm fat mass (right) 0.7 2.7 6.5 -2.3 -2.6 -0.6 -0.9 -0.4 1.4 2.0 1.8
Trunk predicted mass 0.4 2.5 7.7 -2.6 -2.8 1.3 0.8 0.3 -0.0 1.5 -0.9
Standing height 0.6 6.3 15.7 -2.2 -2.7 3.0 2.6 0.6 -2.4 0.7 -4.0
Length of working week for main job 0.9 1.0 1.7 -1.3 -0.9 -1.3 -1.2 0.2 0.8 1.1 0.9
Exposure to tobacco smoke at home 0.1 0.1 0.4 -0.1 -0.1 0.0 -0.4 -0.3 0.6 0.5 0.0
Breastfed as a baby 0.6 0.7 2.0 -0.5 -0.5 0.8 1.0 -0.4 -1.4 0.9 -0.6
Tense / ‘highly strung’ 3.7 6.1 12.3 -3.2 -2.9 -2.7 -3.5 -1.4 2.3 1.6 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 8.2 -1.2 -2.1 -1.5 -1.2 -0.2 1.3 2.9 1.1
Hair/balding pattern: Pattern 4 0.5 1.2 6.0 -0.0 -0.1 0.3 -0.1 -1.1 2.5 0.1 1.6
Birth weight of first child 2.1 3.8 8.9 -2.6 -3.0 -0.3 -0.4 2.1 1.0 2.5 1.6
Peak expiratory flow (PEF) 0.9 2.2 5.2 -1.6 -2.2 0.8 0.6 -1.9 0.3 2.3 -0.5
Pulse wave reflection index 0.5 0.6 1.6 -0.3 -1.2 -0.1 -0.2 -0.2 1.3 1.0 0.5
Ever highly irritable/argumentative for 2 days 1.4 1.7 5.3 -2.1 -2.3 -1.1 -1.0 -0.3 -0.3 0.9 -0.5
Loud music exposure frequency 0.2 0.2 0.8 -0.0 -0.3 0.5 0.1 -0.9 0.5 -0.7 -0.2
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 5.3 -2.0 -1.6 1.5 1.3 0.7 0.4 2.3 0.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.5 -0.9 -0.4 -0.9 -1.0 1.6 0.5 0.1 0.7
Blood clot in the leg (DVT) 2.3 3.0 5.7 -1.6 -1.8 -1.8 -2.1 0.6 1.4 1.6 2.4
Medication: Paracetamol 0.4 0.7 1.7 -0.8 -0.8 -0.8 -1.0 0.1 1.3 0.6 0.7
Headache pain in last month 0.2 0.4 2.1 0.3 0.2 -0.3 -0.3 0.7 1.4 0.4 0.6
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.2 0.8 1.2 0.2 0.7 -0.3 -1.0 -1.5 -1.3
Glaucoma (self-reported) 0.4 0.4 1.0 0.6 0.9 1.0 0.8 -0.0 -0.4 -0.2 0.6
Gout (self-reported) 1.4 1.9 9.7 0.1 0.1 1.6 1.3 3.1 0.1 0.9 0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.8 0.5 0.5 -0.9 -1.4 0.8 0.4 -1.1 -0.1
Medication: Amlodipine 0.6 0.9 2.8 1.4 0.4 0.3 0.1 0.3 1.7 -0.3 1.3
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 0.6 0.3 -0.3 -0.2 -0.0 0.8 -0.3 0.4
Birth weight 0.3 0.6 1.3 -0.9 -1.0 -0.2 -0.4 0.8 1.1 0.8 0.1
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.1 0.9 0.6 -0.6 0.1 -0.3 -1.0 -0.4 -0.8
High blood pressure (siblings) 0.3 0.5 1.1 0.1 -0.4 1.0 0.8 -0.9 -0.4 -0.0 -0.9
Forced vital capacity (FVC), Best measure 0.8 3.1 9.9 -0.1 0.3 1.1 1.6 -1.8 -2.2 -1.6 -3.1
Body fat percentage 0.8 3.2 6.1 -2.1 -2.5 -1.3 -1.6 -0.1 1.8 1.9 2.0
Leg fat percentage (right) 0.8 2.9 4.9 -1.9 -2.2 -1.7 -2.0 -0.9 1.6 1.7 1.3
Arm fat-free mass (right) 0.5 2.5 9.2 -2.9 -3.0 0.2 -0.4 0.3 0.7 1.4 -0.3
Exposure to tobacco smoke outside home 1.2 1.5 6.4 0.2 -0.5 -0.7 -0.6 -1.0 2.5 0.8 1.8
Comparative body size at age 10 1.7 4.6 8.7 -1.8 -1.7 -2.7 -2.4 1.4 3.0 0.8 2.5
Number of full brothers 0.8 1.0 3.1 -0.2 -0.6 -1.6 -1.8 0.8 1.1 0.4 0.4
Worry too long after embarrassment 1.3 2.2 8.8 -1.1 -1.3 -1.2 -1.4 -0.3 3.0 -0.0 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.9 -0.9 -1.4 -1.2 -1.4 0.4 0.0 0.8 -0.7
Wheeze or whistling in the chest in last year 2.6 4.7 9.4 -3.0 -3.1 -1.6 -2.2 -0.3 1.9 2.5 1.2
Number of children fathered 0.3 0.3 0.9 -0.1 0.1 0.5 0.9 -0.1 -0.6 0.5 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.5 -0.7 -0.7 -0.9 -0.3 -0.3 1.2 0.7 0.6
Age at first live birth 0.4 0.6 2.2 0.2 -0.1 1.3 1.5 1.0 -0.2 0.4 -0.2
Pulse wave peak to peak time 0.2 0.3 0.7 -0.7 -0.5 -0.8 -0.4 0.6 0.1 0.2 -0.4
Health satisfaction 0.7 0.9 1.7 -1.3 -1.3 0.9 0.1 0.5 0.6 1.3 0.5
Shortness of breath walking on level ground 0.2 0.3 1.1 0.1 -0.1 0.1 -0.2 -1.1 -0.3 -0.3 -0.9
Qualifications: College or University degree 2.6 8.1 24.6 1.5 2.6 1.0 1.9 -0.5 -4.3 -2.8 -5.0
Eye problems/disorders: None of the above 2.9 3.3 8.4 -1.5 -2.0 -1.3 -1.5 0.4 2.9 1.4 2.4
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.9 0.5 0.3 1.7 1.5 0.9 0.6 0.5 0.9
Emphysema/chronic bronchitis 1.1 1.2 3.0 1.2 0.8 1.5 1.7 -0.3 -0.8 -0.9 -1.0
Medication for pain relief, constipation, heartburn 0.4 0.6 1.4 0.8 0.5 0.8 1.2 0.7 -0.9 -0.8 -0.6
Neck or shoulder pain in last month 0.7 1.0 3.6 -0.9 -0.6 -1.9 -1.8 0.4 0.2 -0.0 0.1
Medication: Blood pressure 0.6 1.1 2.8 -1.0 -1.4 0.3 0.1 1.0 0.4 1.7 1.4
Angina (self-reported) 0.2 0.3 1.5 0.3 0.3 0.4 -0.3 -1.2 0.1 -0.3 0.1
Migraine (self-reported) 1.6 1.9 6.0 0.1 -0.8 1.1 1.4 1.1 1.3 1.7 2.4
Medication: Ibuprofen 0.3 0.4 1.3 0.2 0.4 -0.5 -0.9 -0.2 0.5 -1.1 -0.3
Medication: Allopurinol 1.9 2.6 8.3 0.8 0.5 2.4 2.1 2.9 0.6 0.2 1.0
Medication: Omeprazole 0.4 0.4 2.1 0.3 -0.7 -0.3 -0.2 -1.4 0.4 0.7 0.1
Medication: Seretide 50 evohaler 0.8 0.9 2.2 -0.4 -0.2 -1.4 -1.5 -1.1 0.1 -0.6 -0.9
Mean time to correctly identify matches 0.4 0.7 1.8 0.7 0.6 -0.3 -0.4 -0.9 1.1 -1.4 0.8
Heart disease (mother) 0.6 0.7 1.5 1.2 1.2 0.4 0.3 -0.4 -1.0 -1.0 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.6 -0.8 -1.0 -1.2 -1.1 -0.1 0.7 0.6 1.0
Whole body fat mass 0.9 3.6 9.2 -2.7 -3.0 -0.9 -1.3 0.1 1.5 2.1 1.6
Leg fat mass (right) 1.0 3.9 9.2 -2.8 -3.0 -1.4 -1.8 -0.4 1.7 2.1 1.3
Arm predicted mass (right) 0.5 2.5 9.4 -2.9 -3.1 0.4 -0.1 0.2 0.6 1.4 -0.4
Pulse rate, automated reading 0.2 0.6 3.1 -0.1 0.0 0.5 0.5 -1.8 -0.9 -0.1 -0.6
Alcohol intake frequency. 0.3 0.6 2.2 0.3 0.4 -0.9 -0.5 -0.7 -1.5 -0.7 -0.5
Comparative height size at age 10 1.8 9.9 31.5 -4.4 -5.6 2.2 1.4 1.8 1.0 4.1 0.6
Number of full sisters 0.5 0.6 1.3 1.0 0.7 -0.1 -0.7 -0.9 0.6 -1.1 0.7
Suffer from ‘nerves’ 1.3 2.0 3.9 -1.5 -1.2 -1.8 -2.0 -0.5 1.8 0.3 1.2
Overall health rating 0.8 1.8 4.2 -1.5 -1.6 -0.3 -1.4 0.0 2.0 1.1 1.4
Chest pain or discomfort 0.3 0.5 1.3 -0.9 -1.1 0.1 -0.4 -1.1 0.6 0.5 0.2
Had major operations 0.6 0.6 1.4 -0.5 -0.8 -0.2 -0.1 1.1 0.8 1.0 1.2
Age at last live birth 0.1 0.1 0.3 -0.2 -0.2 -0.3 -0.0 0.5 -0.5 0.2 -0.1
Family relationship satisfaction 2.0 2.5 6.2 -1.0 -1.7 -1.5 -1.5 1.1 2.5 1.1 1.8
Leg pain on walking 0.3 0.4 0.7 -0.8 -0.5 -0.7 -0.7 -0.8 0.7 0.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.5 -0.5 -0.7 -1.0 -1.2 -1.1 0.6 0.8 1.0
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.5 0.2 -0.1 1.2 1.0 -0.1 0.2 0.9 -0.1
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 6.3 2.5 2.5 2.1 2.2 0.9 -1.3 -1.1 -0.7
Medication: Aspirin 0.5 0.6 2.0 1.3 1.4 -0.0 -0.3 0.2 -1.0 -0.5 -0.5
Supplements: Vitamin C 0.5 0.6 1.5 -1.1 -0.6 0.5 0.4 -1.2 0.3 1.0 0.1
Knee pain experienced in last month 0.3 0.4 0.9 -0.9 -0.8 -0.6 -0.6 0.1 0.1 0.6 0.7
Hypertension (Self-reported) 0.3 0.7 2.2 0.7 -0.0 0.9 0.6 -1.5 -1.1 0.2 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.0 -0.8 -0.9 -0.8 -0.5 -1.4 0.2 0.2 -0.1
Illnesses of father: Heart disease 0.9 1.3 2.5 1.1 1.0 1.1 1.1 -1.6 -1.1 -0.9 -0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.5 0.7 0.6 0.3 0.2 0.1 0.0 -0.4 0.1
Smoking status: Previous 0.7 1.0 4.5 -0.2 -0.1 -1.4 -1.1 -2.1 0.4 0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.7 -1.1 -1.2 1.3 1.2 -0.3 -0.6 0.8 -0.9
Whole body fat-free mass 0.4 2.4 7.7 -2.6 -2.8 1.2 0.7 0.5 0.4 1.5 -0.2
Leg fat-free mass (right) 0.4 1.9 5.2 -2.1 -2.3 1.4 1.1 0.6 0.5 1.3 0.5
Arm fat percentage (left) 0.6 2.5 6.1 -1.6 -1.8 -0.9 -1.1 -0.2 1.7 1.7 2.5
Average weekly red wine intake 0.1 0.1 0.4 -0.6 -0.6 -0.1 0.1 0.1 0.0 -0.2 0.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.8 0.0 0.0 -1.2 -1.3 -0.2 -0.7 -1.0 -0.4
Mood swings 2.4 4.4 8.7 -2.5 -2.2 -2.8 -2.9 -1.4 1.6 1.5 0.2
Loneliness, isolation 0.4 0.6 1.7 -0.6 -0.9 -0.8 -1.3 -0.8 0.6 0.5 -0.5
Long-standing illness, disability or infirmity 1.0 1.5 4.7 0.6 0.6 0.2 -0.2 -1.2 -2.2 -1.6 -1.6
Ever had bowel cancer screening 0.1 0.2 0.4 -0.2 -0.4 0.4 0.2 0.6 0.2 0.7 0.2
Diabetes diagnosed by doctor 2.6 4.3 10.2 3.2 2.5 0.9 0.8 -1.1 -1.6 -2.9 -2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.5 -0.6 -0.3 -0.3 -0.5 -1.2 0.5 -0.7 -0.3
Friendships satisfaction 0.8 1.0 2.1 -1.0 -1.3 0.0 -0.0 0.7 1.3 1.4 0.9
Qualifications: nursing, teaching 0.5 0.8 2.7 -0.1 0.4 0.9 1.0 1.6 -0.9 -0.4 -0.9
Commuting to job workplace: Walk 0.3 0.4 1.1 -0.1 0.3 -0.3 -0.0 -0.2 -1.0 -1.1 -0.9
Eye problems/disorders: Cataract 1.1 1.2 2.7 0.5 1.1 0.8 1.2 -0.6 -1.6 -0.8 -1.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.6 -0.5 -0.0 0.1 0.9 -0.3 0.6 -0.8
Medication for cholesterol 1.5 2.3 4.7 -1.8 -1.0 -0.7 -0.6 1.9 2.2 1.0 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 4.0 -1.0 -1.2 -1.1 -0.6 0.3 1.2 1.6 2.0
Back pain experienced in last month 1.7 2.4 6.6 -2.4 -2.6 -0.2 -0.7 -1.4 0.9 1.9 0.7
Mineral and other dietary supplements 1.1 1.5 3.5 -1.5 -1.7 -0.7 -0.6 1.9 1.2 0.6 0.8
Breast cancer (self-reported) 0.5 0.6 1.6 0.6 -0.2 0.5 1.2 1.2 0.3 0.6 0.7
Asthma (self-reported) 0.3 0.7 1.7 0.1 -0.9 1.0 0.6 -0.4 0.9 1.3 0.6
Osteoporosis (self-reported) 0.8 1.0 2.5 1.6 1.0 1.2 1.1 -1.2 0.1 -0.4 0.3
Osteoarthritis (self-reported) 1.0 1.3 3.7 -1.9 -1.5 0.5 0.3 -1.4 0.5 1.4 0.6
Medication: Aspirin 0.5 0.7 2.5 1.4 1.6 0.5 0.0 -0.1 -0.8 -0.4 -0.3
Medication: Gliclazide 1.1 1.2 5.3 0.0 0.0 -0.6 -1.0 -2.3 0.4 -0.3 -1.7
Illnesses of father: None of the above (group 1) 1.2 1.4 2.8 -0.8 -1.0 -1.7 -1.0 0.7 1.3 1.1 1.7
Smoking status: Current 1.2 1.9 3.7 -1.9 -1.4 -0.1 -0.4 -0.9 1.7 1.9 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.6 8.5 1.0 1.7 0.5 1.4 -2.9 -1.0 -2.0 -1.2
Whole body water mass 0.4 2.4 7.7 -2.6 -2.8 1.2 0.8 0.3 0.3 1.5 -0.2
Leg predicted mass (right) 0.4 2.0 5.3 -2.1 -2.3 1.4 1.1 0.6 0.6 1.4 0.6
Arm fat mass (left) 0.6 2.4 5.5 -2.2 -2.4 -0.8 -1.0 -0.5 1.2 1.7 1.6
Number of self-reported non-cancer illnesses 0.7 1.1 2.0 -1.0 -1.4 1.1 0.7 -1.2 0.9 1.4 0.4
Average weekly champagne plus white wine intake 0.8 1.1 2.7 0.8 1.0 -1.2 -0.6 1.6 -1.1 -0.8 -0.9
Miserableness 2.5 4.4 8.8 -2.0 -2.1 -3.0 -2.9 -1.3 2.1 1.3 1.2
Guilty feelings 1.9 2.9 8.2 -1.4 -1.4 -2.7 -2.9 -1.8 0.8 0.2 0.2
Wears glasses or contact lenses 0.7 0.8 1.8 1.2 1.3 -0.3 0.2 0.2 -1.2 -0.8 -0.9
Ever taken oral contraceptive pill 0.6 0.7 2.0 0.1 1.1 -1.0 -1.0 -0.2 -0.1 -1.4 -0.3
Hearing aid user 2.9 3.3 6.6 2.4 2.6 0.2 0.2 -2.2 -1.3 -2.3 -1.5
Mother’s age at death 0.8 1.0 2.1 1.1 1.0 -0.4 -0.1 0.8 -0.7 -1.4 -1.4
Financial situation satisfaction 0.8 1.0 4.2 0.2 -0.6 -0.7 -0.8 -2.0 1.5 -0.0 0.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.7 0.4 -0.3 -0.1 -0.2 0.8 0.1 0.1 -0.1
Commuting to job workplace: Public transport 1.5 1.8 3.5 1.4 1.8 -0.6 -0.0 0.4 -1.5 -1.9 -1.6
Eye problems/disorders: Glaucoma 0.2 0.3 1.1 -0.5 -0.2 0.4 -0.0 -0.4 -0.1 0.7 1.1
Medication: Blood pressure 1.8 3.4 5.8 2.2 1.8 1.1 1.2 -2.0 -2.4 -1.1 -2.4
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.3 1.6 1.7 0.4 0.6 -1.1 -1.8 -1.3 -1.1
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.2 1.6 1.8 1.0 1.4 -1.5 -1.3 -0.4 -1.1
High cholesterol (Self-reported) 0.2 0.4 1.0 0.6 0.3 0.9 0.4 -1.0 0.6 -0.2 -0.3
Medication: Bendroflumethiazide 0.3 0.5 2.3 0.3 0.3 -0.6 -0.5 -0.7 -1.5 -0.4 -0.4
Medication: Paracetamol 0.7 1.1 2.5 -1.1 -0.9 -1.1 -1.4 0.7 1.6 0.6 0.8
Medication: Lisinopril 0.3 0.3 1.5 -0.0 -0.1 0.0 0.1 -0.1 -1.2 0.1 -1.0
Medication: Atorvastatin 0.2 0.3 1.5 -0.4 -0.0 0.2 -0.1 -0.1 1.2 0.2 0.6
Illnesses of father: High blood pressure 1.5 1.9 4.6 1.1 1.4 1.3 0.9 -0.7 -1.8 -1.1 -2.1
Alcohol drinker status: Never 0.5 0.6 2.7 0.8 0.5 -0.2 0.4 1.1 -1.6 -0.5 -0.0
Ever smoked 1.1 1.9 3.7 -1.6 -1.2 -0.4 -0.8 -1.7 1.9 1.4 1.3
Basal metabolic rate 0.5 2.8 9.4 -2.8 -3.1 1.0 0.6 0.2 0.6 1.8 0.0
Leg fat percentage (left) 0.9 3.3 5.2 -1.9 -2.3 -1.7 -2.1 -0.6 1.8 1.9 1.6
Arm fat-free mass (left) 0.5 2.7 9.9 -3.0 -3.1 0.1 -0.3 0.3 0.4 1.6 -0.3
Number of operations (self-reported) 0.7 1.1 3.5 -0.3 -0.8 0.2 -0.0 1.2 1.5 0.9 1.9
Average weekly beer plus cider intake 0.5 0.7 2.6 -0.6 -0.3 -0.2 -0.7 -0.7 1.6 0.6 1.1
Irritability 1.6 2.8 8.8 -1.4 -1.2 -1.6 -1.9 -0.8 3.0 0.9 1.5
Risk taking 0.5 0.8 2.0 1.0 0.8 -0.9 -0.7 0.4 -0.4 -1.4 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.4 -0.5 -0.8 -0.8 -0.9 1.6 0.6 1.1 0.5
Fractured/broken bones in last 5 years 0.3 0.3 0.8 -0.8 -0.7 -0.6 -0.3 -0.6 0.0 0.9 0.1
Age started oral contraceptive pill 0.9 1.1 3.3 -0.9 -0.6 -1.8 -1.5 -0.9 -1.2 0.0 -0.0
Diastolic blood pressure, automated reading 0.5 1.6 4.9 -1.4 -2.1 0.8 0.3 0.2 0.7 2.2 0.5
Ever depressed for a whole week 0.8 0.9 5.2 -0.3 -0.5 -0.3 -0.4 -2.3 -0.8 0.2 -1.0
Unable to work because of sickness or disability 0.2 0.3 1.1 -0.9 -1.1 0.3 -0.3 -0.0 0.4 0.5 0.2
Commuting to job workplace: Cycle 0.5 0.6 1.2 0.4 0.9 -0.1 -0.4 -1.0 -0.7 -1.1 -1.1
Myopia 0.2 0.3 0.9 0.3 -0.0 0.8 0.8 1.0 0.5 0.1 0.4
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.8 0.3 1.0 -0.7 -0.2 1.4 0.2 -1.2 -0.3
Cholesterol lowering medication 2.7 4.0 7.1 2.7 2.1 1.7 1.5 -2.7 -1.2 -1.5 -2.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.1 -0.4 -1.2 -0.6 -0.7 -1.5 1.1 1.3 0.9
Pain experienced in last month 1.6 2.6 6.2 1.7 1.9 -0.9 -0.5 -0.7 -2.0 -1.7 -2.5
Supplements: Calcium 1.3 1.5 3.0 -0.7 -0.8 1.3 0.9 0.7 1.7 1.3 1.7
Basal cell carcinoma (self-reported) 0.6 0.7 1.8 -0.7 -1.3 0.2 -0.1 1.0 -0.6 1.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.6 -0.2 -1.1 1.1 0.8 0.5 1.1 1.3 0.4
Deep venous thrombosis (DVT) (self-reported) 2.3 2.9 4.6 -1.8 -1.9 -1.9 -2.1 0.3 1.4 1.4 2.1
Heart disease (siblings) 0.4 0.5 1.9 0.4 -0.1 0.4 0.2 0.3 1.4 -0.1 1.2
Alcohol drinker status: Previous 0.3 0.3 0.8 0.1 0.8 0.7 0.3 0.5 0.2 -0.9 0.1
Pack years of smoking 0.3 0.4 1.1 -0.5 -1.0 -0.3 -0.9 -0.2 0.3 0.7 0.3
Impedance of whole body 0.3 1.4 5.5 1.0 0.9 -0.1 0.1 -0.1 -1.5 -1.3 -2.4
Leg fat mass (left) 1.1 4.2 9.9 -2.8 -3.2 -1.5 -1.9 -0.1 1.8 2.2 1.5
Arm predicted mass (left) 0.5 2.6 9.7 -2.8 -3.1 0.3 -0.1 0.2 0.5 1.6 -0.0