[Hub]/) : Traits : Heel T-Score : ← →

chr17:78,826,134-80,908,501

Best TWAS P=1e-17 · Best GWAS P=4.69e-23 conditioned to 2.59e-109

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRRC45	0.09	0.10	enet	7	0.10	1.2e-11	7.8	-7.6	2.9e-14	-0.09	0.26	0.74	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MRPL12	0.04	0.02	lasso	4	0.03	3.8e-04	4.7	5.4	6.2e-08	0.06	0.32	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	STRA13	0.45	0.38	lasso	4	0.40	1.6e-51	6.0	-5.9	4.5e-09	-0.04	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	LRRC45	0.23	0.06	lasso	3	0.05	1.0e-04	7.7	-7.9	2.5e-15	-0.11	0.19	0.77	TRUE
5	GTEx	Adipose Subcutaneous	STRA13	0.28	0.26	lasso	3	0.26	5.0e-21	6.0	-6.0	2.2e-09	-0.04	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	LRRC45	0.18	0.03	enet	12	0.10	9.0e-06	7.7	-6.5	6.3e-11	-0.09	0.35	0.60	FALSE
7	GTEx	Adipose Visceral Omentum	STRA13	0.18	0.15	lasso	4	0.14	8.0e-08	6.0	6.3	3.5e-10	0.03	0.86	0.05	FALSE
8	GTEx	Artery Coronary	LRRC45	0.18	0.00	enet	22	0.00	3.8e-01	4.8	-5.7	9.3e-09	-0.03	0.04	0.16	TRUE
9	GTEx	Artery Tibial	LRRC45	0.09	0.07	lasso	4	0.04	2.0e-04	7.7	-6.6	3.4e-11	-0.09	0.23	0.73	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	NPLOC4	0.20	0.01	enet	13	0.01	1.7e-01	4.1	5.4	6.0e-08	0.10	0.17	0.04	TRUE
11	GTEx	Cells Transformed fibroblasts	LRRC45	0.08	0.08	enet	3	0.08	2.6e-06	7.7	-8.0	8.9e-16	-0.09	0.27	0.73	FALSE
12	GTEx	Cells Transformed fibroblasts	STRA13	0.19	0.23	lasso	1	0.22	4.9e-16	6.0	-6.0	2.3e-09	-0.04	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	DUS1L	0.05	0.00	enet	11	0.01	9.7e-02	4.4	-5.5	3.2e-08	-0.08	0.08	0.04	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	STRA13	0.20	0.14	enet	4	0.16	3.1e-06	5.8	-6.0	2.1e-09	-0.04	0.40	0.42	FALSE
15	GTEx	Esophagus Mucosa	STRA13	0.19	0.14	lasso	2	0.12	2.8e-08	6.0	-5.6	1.9e-08	-0.03	0.92	0.06	TRUE
16	GTEx	Esophagus Muscularis	STRA13	0.40	0.33	lasso	2	0.32	4.2e-20	6.0	-6.0	2.0e-09	-0.03	1.00	0.00	FALSE
17	GTEx	Heart Atrial Appendage	LRRC45	0.19	0.06	enet	9	0.12	6.7e-06	4.6	-6.5	8.5e-11	-0.11	0.33	0.56	FALSE
18	GTEx	Heart Atrial Appendage	STRA13	0.25	0.15	enet	4	0.16	1.2e-07	5.8	-6.0	1.9e-09	-0.06	0.87	0.06	FALSE
19	GTEx	Heart Left Ventricle	RAC3	0.17	0.04	enet	17	0.08	7.3e-05	2.2	-7.0	3.8e-12	0.04	0.07	0.15	TRUE
20	GTEx	Lung	STRA13	0.16	0.16	lasso	3	0.15	1.2e-11	6.0	-5.8	6.5e-09	-0.04	1.00	0.00	FALSE
21	GTEx	Muscle Skeletal	STRA13	0.20	0.09	lasso	6	0.10	5.4e-10	6.0	-5.6	2.6e-08	-0.04	0.96	0.04	FALSE
22	GTEx	Nerve Tibial	STRA13	0.18	0.17	enet	2	0.12	1.4e-08	6.0	-6.0	2.3e-09	-0.04	1.00	0.00	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	STRA13	0.23	0.18	enet	5	0.10	6.6e-06	6.0	-6.1	1.1e-09	-0.04	0.99	0.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	STRA13	0.12	0.13	lasso	3	0.12	7.9e-10	6.0	-6.0	2.6e-09	-0.04	1.00	0.00	FALSE
25	GTEx	Thyroid	STRA13	0.40	0.34	lasso	5	0.34	2.3e-26	6.0	-6.1	1.3e-09	-0.04	1.00	0.00	FALSE
26	GTEx	Thyroid	ASPSCR1	0.23	0.15	enet	19	0.09	1.2e-07	5.9	-5.5	4.8e-08	-0.09	1.00	0.00	FALSE
27	GTEx	Whole Blood	AC132872.1	0.07	0.00	lasso	4	0.01	8.4e-02	6.8	6.0	2.2e-09	-0.01	0.07	0.03	FALSE
28	YFS	Blood	ASPSCR1	0.11	0.07	lasso	9	0.06	7.9e-20	5.6	-5.7	1.0e-08	-0.11	1.00	0.00	TRUE
29	YFS	Blood	NPLOC4	0.13	0.04	enet	38	0.08	3.1e-26	2.6	5.6	2.5e-08	0.12	1.00	0.00	TRUE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC45	0.08	0.07	lasso	3	0.04	1.4e-03	5.8	-5.9	4.6e-09	-0.04	0.08	0.70	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRC45	0.02	0.03	blup	36	0.02	1.5e-03	7.8	-7.2	7.2e-13	-0.07	0.04	0.23	TRUE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDE6G	0.11	0.01	blup	46	0.04	9.2e-06	5.0	-5.4	5.9e-08	-0.03	0.08	0.74	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRA13	0.05	0.04	blup	33	0.05	5.0e-06	7.8	-6.5	8.3e-11	-0.06	0.30	0.70	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC45	0.05	0.07	lasso	6	0.06	9.5e-08	7.8	-7.8	4.9e-15	-0.08	0.24	0.76	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRA13	0.06	0.07	blup	33	0.07	3.3e-08	6.0	-7.7	1.4e-14	-0.04	0.45	0.55	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TSPAN10	0.09	0.10	lasso	7	0.09	1.6e-10	5.0	5.1	2.9e-07	-0.01	0.12	0.87	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC45	0.10	0.02	blup	35	0.04	8.0e-03	8.4	-8.6	1.0e-17	-0.05	0.01	0.54	TRUE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	STRA13	0.05	0.03	lasso	3	0.02	1.8e-03	7.8	-7.8	7.9e-15	-0.09	0.07	0.53	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CCDC57	0.34	0.04	enet	20	0.17	1.6e-06	-5.2	-6.3	2.5e-10	-0.06	0.04	0.89	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	DCXR	0.09	0.03	blup	38	0.09	9.5e-09	-2.8	-5.5	3.8e-08	-0.12	0.78	0.18	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	STRA13	0.07	0.12	lasso	6	0.10	3.2e-10	5.1	-5.8	5.6e-09	-0.06	0.70	0.30	TRUE