TWAS hub - DUS1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.054	0.027	0.00670	0.000	NA	0.007	NA	0.002	3.2e-01	NA	9.7e-02	NA	2.2e-01
2	GTEx	Testis	0.250	0.087	0.00750	0.220	NA	0.218	NA	0.227	3.8e-10	NA	5.0e-10	NA	1.9e-10
3	GTEx	Thyroid	0.074	0.028	0.00011	0.048	NA	0.008	NA	0.022	1.5e-04	NA	7.3e-02	NA	7.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Average weekly red wine intake	5.9	8.8	17.2	-4.2	-0.8	-2.9
Hair Pigment	5.5	158.1	470.9	21.7	-1.8	-0.3
Nervous feelings	5.5	10.3	19.3	4.4	-0.4	3.4
Leg fat percentage (right)	4.7	16.8	34.3	-5.9	1.4	-3.8
Leg fat percentage (left)	4.1	14.9	29.3	-5.4	1.3	-3.7
Past tobacco smoking	4.0	7.4	12.0	2.9	1.4	3.5
Handedness (chirality/laterality): Left-handed	4.0	4.8	10.4	-1.8	-0.9	-3.2
Smoking status: Previous	3.7	5.5	8.8	-2.7	-0.7	-3.0
Basal cell carcinoma (self-reported)	3.6	4.3	12.7	-3.6	-0.2	-0.4
Alzheimer’s Disease (in mother)	3.2	3.8	5.7	-1.4	-2.4	-1.9
Allergy or Eczema	3.1	8.2	16.6	-4.1	0.3	-2.8
Medication: Allopurinol	3.1	4.1	7.1	-2.2	0.5	-2.7
Waist circumference	3.0	11.0	17.8	-3.9	-0.4	-4.2
Body Mass Index (BMI) (2010)	2.9	4.0	10.2	-1.3	0.0	-3.2
Time employed in main current job	2.9	3.3	8.9	-0.7	3.0	0.8
Forced vital capacity (FVC), Best measure	2.9	10.5	22.9	2.9	-0.2	4.8
Number of full brothers	2.8	3.5	6.9	1.4	1.3	2.6
Sitting height	2.7	19.4	47.1	3.3	0.6	6.9
Medication: Omeprazole	2.7	3.2	4.8	2.2	1.0	2.0
Gout (self-reported)	2.6	3.6	8.5	-1.3	-0.6	-2.9
Medication: Lisinopril	2.6	3.3	5.1	-0.4	-2.2	-2.3
Unable to work because of sickness or disability	2.6	3.4	5.8	0.8	1.9	2.4
BMI	2.5	14.7	23.5	-4.5	0.1	-4.8
Body mass index (BMI)	2.5	10.7	16.2	-3.8	1.2	-4.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.1	16.6	2.6	-0.7	4.1
Cholesterol lowering medication	2.5	3.7	6.8	-2.1	0.1	-2.6
Number of full sisters	2.4	2.9	4.4	2.1	0.8	1.9
Knee pain experienced in last month	2.4	3.7	5.1	2.1	-1.2	2.2
Forced vital capacity (FVC)	2.3	8.8	19.5	2.5	0.8	4.4
Leg fat mass (right)	2.3	8.8	16.9	-4.1	1.2	-2.9
Forced expiratory volume in 1-second (FEV1)	2.2	7.3	17.4	2.1	0.1	4.2
Impedance of arm (left)	2.2	10.4	22.0	3.0	0.3	4.7
Standing height	2.2	21.6	38.8	5.0	-0.8	6.2
Medication: Seretide 50 evohaler	2.2	2.5	2.9	1.7	1.7	1.3
Alzheimer’s Disease (including proxy)	2.1	3.0	4.4	-0.6	-2.1	-2.1
Hayfever, allergic rhinitis or eczema	2.1	4.6	9.3	-3.0	0.8	-2.0
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.9	-1.0	-0.7	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	8.1	2.2	-0.4	2.9
Eye problems/disorders: Cataract	2.1	2.4	4.0	1.6	0.9	-2.0
Relative age of first facial hair	2.0	4.0	6.8	2.6	2.1	0.9
Body fat percentage	2.0	7.8	15.1	-3.9	1.4	-2.5
Comparative body size at age 10	2.0	5.5	12.8	-3.6	0.1	-1.9
Heart disease (mother)	2.0	2.4	6.8	2.6	0.7	0.2
Ever smoked	2.0	3.6	5.3	-2.0	-1.3	-2.3
Pain experienced in last month	2.0	3.4	8.6	-1.2	-0.2	-2.9
Leg fat mass (left)	2.0	7.8	14.1	-3.8	1.0	-2.9
Medication: Simvastatin	1.9	2.8	4.0	-2.0	1.3	-1.7
Impedance of arm (right)	1.9	9.1	16.7	3.2	0.6	4.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	6.7	0.2	-0.6	2.6
Age at First Birth	1.8	2.6	5.7	-0.1	-2.4	-1.4
Heel T-Score	1.8	13.9	30.6	-5.5	-2.1	-2.6
Diabetes (father)	1.8	2.3	4.4	2.1	-1.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.4	1.8	0.9	2.1
Number of live births	1.8	2.6	6.5	0.1	-1.1	2.5
Height	1.7	32.0	65.3	5.4	-1.3	8.1
Waist Hip Ratio (WHR)	1.7	7.6	13.8	-2.2	-2.1	-3.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.2	0.5	-1.8	1.4
Breastfed as a baby	1.7	2.1	5.7	-2.4	0.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.8	1.7	-1.3	1.0
Average weekly champagne plus white wine intake	1.7	2.3	5.1	-0.3	-1.3	-2.3
Ovarian Cancer	1.6	2.2	5.2	0.8	-2.3	-0.8
Smoking Status	1.6	3.9	7.5	-1.2	-1.6	-2.7
Medication: Metformin	1.6	2.3	2.9	-1.6	-1.7	-1.2
Arm fat percentage (right)	1.6	6.2	8.4	-2.9	1.4	-2.9
Hair/balding pattern: Pattern 3	1.6	2.3	5.4	-2.3	0.2	-1.3
Medication: Blood pressure	1.6	2.7	8.0	-0.4	-0.1	-2.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	5.6	-2.4	-0.5	0.0
Arm fat percentage (left)	1.6	6.4	9.9	-3.1	1.5	-2.6
Mood swings	1.6	2.9	6.3	-0.3	2.5	1.5
Ever had bowel cancer screening	1.6	1.9	3.2	-1.8	-0.1	-1.5
Medication: Aspirin	1.6	2.1	3.7	-1.9	-0.7	-1.5
Prostate Cancer	1.5	2.2	6.2	-2.5	0.0	-0.5
Primary Biliary Cirrhosis	1.5	2.2	4.0	2.0	0.2	1.6
Ever had hysterectomy (womb removed)	1.5	1.7	2.9	-1.7	-1.5	-0.1
Vitamin and mineral supplements	1.5	2.0	3.9	-1.3	-0.6	-2.0
Prospective memory result	1.5	1.8	3.8	1.9	-0.9	1.0
Shortness of breath walking on level ground	1.5	1.8	5.3	-0.1	-0.4	2.3
Qualifications: College or University degree	1.5	4.8	9.2	-3.0	-0.1	-2.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.4	1.3	1.1	1.5
Severe depression (siblings)	1.4	1.6	3.7	1.0	-0.4	1.9
Alcohol usually taken with meals	1.4	2.2	3.9	-2.0	-1.0	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	6.4	0.6	-0.3	2.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.5	1.9	-1.1	0.8
Neck or shoulder pain in last month	1.4	2.0	3.6	1.4	0.5	1.9
Major Depression (MDD)	1.3	1.6	4.8	0.0	0.0	2.2
Medication: Ramipril	1.3	1.6	2.6	-1.2	-0.9	-1.6
Depression (self-reported)	1.3	1.6	3.5	0.3	1.0	1.9
Eye problems/disorders: None of the above	1.3	1.5	2.9	-1.1	-0.6	1.7
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.1	1.8	-1.2	0.3
Emphysema/chronic bronchitis	1.3	1.5	2.6	1.1	1.6	0.8
Age at last live birth	1.3	1.9	2.9	1.6	-1.7	-0.2
Supplements: Vitamin C	1.3	1.6	3.2	1.1	-0.5	1.8
Commuting to job workplace: Walk	1.3	1.4	3.5	0.4	0.6	1.9
Impedance of whole body	1.3	6.5	17.1	1.5	0.4	4.1
Schizophrenia vs Biploar Disorder	1.2	1.5	3.0	1.7	0.0	1.3
Age when periods started (menarche)	1.2	2.8	5.0	1.9	-0.2	2.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	5.0	-2.2	-0.2	-1.7
Alcohol intake frequency.	1.2	2.8	5.5	2.3	1.4	1.0
Comparative height size at age 10	1.2	6.7	10.9	2.8	-1.2	3.3
Hypertension (Self-reported)	1.2	3.5	8.3	0.7	-1.3	-2.9
Medication for cholesterol	1.2	1.8	3.7	0.0	1.4	1.9
Osteoarthritis (self-reported)	1.2	1.5	2.5	0.3	-1.6	-1.4
Average weekly beer plus cider intake	1.2	1.7	4.8	0.4	2.2	-0.4
Risk taking	1.2	1.8	4.1	2.0	-0.3	1.1
Myopia	1.2	1.8	4.7	2.2	0.8	0.2
Triglycerides	1.1	1.8	3.5	1.3	0.0	-1.9
Relative age voice broke	1.1	1.8	3.2	1.8	1.4	0.4
High blood pressure	1.1	3.0	5.4	1.1	-1.5	-2.3
Falls in the last year	1.1	1.5	2.7	0.9	-0.9	1.7
Pulse rate	1.1	1.8	4.3	2.1	0.2	1.0
Whole body fat mass	1.1	4.4	8.3	-2.9	1.2	-1.9
Pulse rate, automated reading	1.1	3.4	5.8	0.9	1.9	2.4
Suffer from ‘nerves’	1.1	1.8	3.2	0.7	1.8	1.2
Wears glasses or contact lenses	1.1	1.2	3.7	-0.2	0.0	-1.9
Mother’s age at death	1.1	1.3	2.8	-0.8	-1.7	-0.7
Number of operations (self-reported)	1.1	1.7	2.6	1.5	-1.6	0.4
Alzheimer’s Disease (in father)	1.0	1.0	2.3	1.5	-0.3	-0.9
Crohns Disease (2017)	1.0	2.3	4.9	-2.2	-1.4	-0.4
Reaction Time	1.0	1.8	2.9	-1.7	0.6	1.5
Average weekly fortified wine intake	1.0	1.2	1.6	-0.9	1.3	-1.1
Medication: Levothyroxine sodium	1.0	1.6	4.7	0.0	0.4	-2.2
Arm fat mass (right)	1.0	4.2	5.9	-2.4	1.0	-2.4
Exposure to tobacco smoke at home	1.0	1.1	1.8	-1.4	1.0	-0.7
Peak expiratory flow (PEF)	1.0	2.3	6.2	0.5	-0.7	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	3.1	-1.8	0.3	-0.5
Medication: Aspirin	1.0	1.3	2.6	-1.6	-0.4	-1.0
Illnesses of father: Heart disease	1.0	1.4	3.0	1.0	-0.7	1.7
Loneliness, isolation	1.0	1.4	2.7	-1.0	0.7	1.6
Number of self-reported non-cancer illnesses	1.0	1.8	5.0	2.2	-0.5	-0.4
Medication: Atorvastatin	1.0	1.2	2.0	-1.2	-1.4	-0.4
Age started oral contraceptive pill	1.0	1.2	2.3	-0.9	0.7	-1.5
Pack years of smoking	1.0	1.4	2.7	-1.2	0.5	-1.6
Trunk fat percentage	0.9	3.5	7.0	-2.6	1.4	-1.2
Fed-up feelings	0.9	1.7	3.8	-1.9	1.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.7	-0.6	-1.6	-0.2
Hair/balding pattern: Pattern 2	0.9	1.1	2.2	1.5	-1.0	0.4
Had menopause	0.9	1.1	1.5	-0.6	-1.2	-1.2
Heart attack	0.9	1.1	2.8	0.6	-1.7	0.5
Noisy workplace	0.9	1.1	2.9	1.7	0.7	0.2
Length of working week for main job	0.9	1.0	2.7	0.7	1.6	-0.1
Birth weight of first child	0.9	1.6	3.3	1.2	-0.1	1.8
Pulse wave reflection index	0.9	1.1	2.6	0.4	-0.7	-1.6
Age at first live birth	0.9	1.5	3.6	1.9	-0.3	-1.0
Arm fat mass (left)	0.9	3.9	5.7	-2.4	1.1	-2.2
Medication: Blood pressure	0.9	1.7	3.6	0.0	-1.3	-1.9
High cholesterol (Self-reported)	0.9	1.5	2.7	-1.7	0.0	-1.3
LDL Cholesterol	0.8	1.2	3.1	0.7	0.0	-1.7
Current tobacco smoking	0.8	1.2	3.4	1.8	-0.1	0.6
Serious illness, injury or assault to yourself	0.8	1.0	2.4	0.7	0.3	1.6
Number of incorrect matches in round	0.8	1.3	1.8	1.4	-1.1	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.6	-1.9	-0.3	-1.4
Mean time to correctly identify matches	0.8	1.6	3.8	-2.0	-0.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.5	-1.2	0.5	-1.1
Long-standing illness, disability or infirmity	0.8	1.1	2.6	1.6	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.6	1.6	-1.2	1.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.8	-0.3	1.7	0.3
Worry (Nagel 2018)	0.7	1.6	2.5	1.6	-0.7	1.3
Lupus	0.7	1.0	1.6	-1.3	1.1	0.5
Schizophrenia (2014)	0.7	1.5	3.6	1.0	0.0	1.9
Average weekly spirits intake	0.7	0.8	1.5	-1.0	-1.2	-0.2
Sensitivity / hurt feelings	0.7	1.1	3.0	0.4	-0.4	1.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.4	1.6	0.6	-0.0
Pack years adult smoking proportion	0.7	1.1	2.3	-0.8	0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.9	-1.0	-0.8	-1.7
Chronic bronchitis/emphysema (father)	0.7	0.9	2.4	1.5	-0.2	-0.5
Allergy	0.7	1.5	2.9	1.7	-0.9	0.9
Pain all over the body in last month	0.7	0.7	1.6	-1.3	0.7	0.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	0.0	1.0	-1.3
Alcohol intake versus 10 years previously	0.7	1.0	1.6	1.2	0.4	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-1.4	-0.7	0.4
Asthma	0.7	1.4	2.5	1.6	1.2	0.7
Lung cancer (father)	0.7	0.9	1.6	-0.6	-0.8	-1.3
Exposure to tobacco smoke outside home	0.7	0.9	1.4	-1.1	1.2	0.3
Number of children fathered	0.7	0.8	1.8	-1.3	-0.8	-0.4
Breast cancer (self-reported)	0.7	0.8	2.0	-0.0	-1.4	-0.7
Illnesses of father: None of the above (group 1)	0.7	0.8	1.5	-1.2	-0.1	-1.0
Medication: Paracetamol	0.7	1.0	3.0	-1.7	-0.2	0.2
Alcohol drinker status: Never	0.7	0.8	1.8	1.3	0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	2.8	-1.2	1.3	1.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.7	0.3	-1.6	0.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.2	-2.1	0.8	-0.6
HDL Cholesterol	0.6	1.0	1.6	-1.2	0.0	-1.3
Respiratory disease	0.6	1.4	3.1	1.8	0.7	0.8
Lung FVC	0.6	3.2	6.7	1.7	-0.0	2.6
Tanning	0.6	7.2	19.0	-4.4	0.6	1.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.1	-0.1	0.8	1.4
Impedance of leg (right)	0.6	2.8	5.1	-1.8	0.2	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.3	-0.1	1.1	1.0
Trunk fat mass	0.6	2.5	4.7	-2.2	1.2	-1.1
Medication: Lansoprazole	0.6	0.7	1.2	-1.1	0.9	0.4
Hair/balding pattern: Pattern 4	0.6	1.4	2.9	-1.1	1.7	-0.1
Loud music exposure frequency	0.6	0.6	1.7	0.3	0.4	1.3
Had major operations	0.6	0.7	2.0	0.4	-1.4	0.0
Leg fat-free mass (right)	0.6	3.0	8.0	2.8	0.0	1.0
Medication: Gliclazide	0.6	0.6	1.6	-0.5	-1.3	0.3
Leg predicted mass (right)	0.6	3.0	8.1	2.9	-0.1	1.0
Eye problems/disorders: Glaucoma	0.6	0.7	0.8	0.8	-0.9	0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.1	0.9	1.1	-0.7
Medication: Bendroflumethiazide	0.6	0.8	2.5	-0.0	0.2	-1.6
Diastolic blood pressure, automated reading	0.6	2.0	3.7	1.2	-0.9	-1.9
Ever depressed for a whole week	0.6	0.7	1.4	-0.9	1.2	0.0
Systolic Blood Pressure	0.5	2.3	6.5	2.5	-0.5	0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.0	-1.4	-0.8	-0.4
Chronotype (morning person)	0.5	1.1	2.8	-0.3	1.7	0.7
Medication: Co-codamol	0.5	0.6	1.0	0.5	-1.0	-0.7
Diabetes (mother)	0.5	0.6	1.7	-0.1	1.3	0.2
Taking other prescription medications	0.5	0.7	1.3	0.5	1.1	-0.8
Impedance of leg (left)	0.5	2.3	5.7	-1.1	0.0	2.4
Had other major operations	0.5	0.6	1.2	1.1	-0.7	-0.1
Father’s age at death	0.5	0.7	2.0	0.3	-0.1	1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	0.6	-0.2	-1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	0.3	0.9	-1.4
Birth weight	0.5	1.0	1.9	1.0	-0.0	1.4
Worry too long after embarrassment	0.5	0.8	1.1	0.7	1.0	1.1
Angina (self-reported)	0.5	0.6	0.8	0.9	0.5	0.9
Diabetes diagnosed by doctor	0.5	0.8	1.7	-1.3	-0.7	-0.6
Asthma (self-reported)	0.5	0.9	1.5	1.2	1.0	0.6
Heart disease (siblings)	0.5	0.6	1.2	-0.5	1.1	-0.7
Depression (Nagel 2018)	0.4	0.6	1.8	0.2	-0.1	1.3
Irritable Bowel Disease (IBD)	0.4	1.0	2.4	-1.6	-0.4	0.6
Mean Putamen Volume	0.4	0.4	1.2	1.1	0.1	-0.2
Blood Eosinophil Count	0.4	3.2	6.4	-1.5	-1.0	-2.5
Systolic blood pressure, automated reading	0.4	1.0	2.6	0.6	-0.4	-1.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.4	-1.2	-0.2	-0.1
Supplements: Zinc	0.4	0.4	0.7	0.6	0.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-0.9	-0.1	-0.6
Qualifications: None of the above	0.4	0.7	2.0	0.3	1.4	0.4
Diabetes (self-reported)	0.4	0.6	1.6	-1.3	-0.4	-0.3
Happiness	0.4	0.5	1.2	-0.5	1.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.7	0.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.1	-0.0	-0.2	1.4
Migraine (self-reported)	0.4	0.6	1.7	0.0	-0.1	1.3
Overall health rating	0.4	0.9	1.7	0.9	0.3	1.3
Chest pain or discomfort	0.4	0.6	0.9	-0.5	0.9	0.9
Leg pain on walking	0.4	0.5	0.8	-0.7	0.9	0.5
Friendships satisfaction	0.4	0.6	1.4	-1.2	0.3	-0.4
Qualifications: nursing, teaching	0.4	0.6	1.4	-0.6	1.2	-0.3
Mineral and other dietary supplements	0.4	0.6	1.7	-1.3	-0.1	0.3
Smoking status: Current	0.4	0.7	2.0	1.4	-0.3	0.1
Guilty feelings	0.4	0.6	1.5	0.5	1.2	-0.5
Hearing aid user	0.4	0.5	1.1	1.1	0.5	0.1
Illnesses of father: High blood pressure	0.4	0.4	1.3	1.1	-0.2	-0.0
Irritability	0.4	0.7	0.9	0.8	0.7	1.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.3	-0.6	1.0
Supplements: Calcium	0.4	0.5	0.9	1.0	-0.2	-0.7
Alcohol drinker status: Previous	0.4	0.5	1.2	-0.2	1.1	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	0.7	0.0	1.2
Neuroticism (Nagel 2018)	0.3	0.7	0.9	0.8	-0.8	1.0
Schizophrenia (2018)	0.3	0.7	1.0	1.0	0.0	1.0
Ulcerative Colitis (UC)	0.3	0.5	1.4	-0.3	0.4	1.2
Breast Cancer	0.3	0.7	1.5	-0.2	-1.2	0.7
HbA1C	0.3	0.3	0.6	-0.8	0.0	-0.5
Rheumatoid Arthritis	0.3	0.4	1.0	-0.2	0.5	1.0
Ulcerative Colitis	0.3	0.5	1.2	-0.4	0.0	1.1
Hypothyroidism (self reported)	0.3	0.8	1.4	-0.1	0.9	-1.2
Hand grip strength (left)	0.3	0.7	1.2	0.3	-1.1	-1.0
Medication for hormone replacement therapy	0.3	0.3	0.5	0.6	-0.7	0.0
Leg fat-free mass (left)	0.3	1.5	3.9	2.0	0.1	0.8
Townsend deprivation index at recruitment	0.3	0.4	0.5	0.6	0.5	0.7
Supplements: Glucosamine	0.3	0.4	0.6	0.7	-0.4	0.8
Leg predicted mass (left)	0.3	1.6	4.1	2.0	-0.0	0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.0	0.1	-0.8	1.0
Mouth/teeth dental problems	0.3	0.5	1.2	-1.1	0.1	-0.5
Weight	0.3	1.3	2.2	-1.5	0.7	-1.1
Hip circumference	0.3	1.4	3.0	-1.7	1.1	0.1
Worrier / anxious feelings	0.3	0.5	1.3	-0.5	-1.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	-0.5	-1.1	-0.0
Glaucoma (self-reported)	0.3	0.3	0.7	0.8	-0.3	0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	0.9	0.2	0.1
Pulse wave peak to peak time	0.3	0.4	0.8	0.1	0.5	0.9
Back pain experienced in last month	0.3	0.4	0.8	0.6	0.1	0.9
Ever taken oral contraceptive pill	0.3	0.3	0.4	-0.5	-0.5	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	-1.1	-0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.5	-1.2	0.1	0.2
Crohns Disease (2012)	0.2	0.2	0.6	-0.8	0.0	0.3
Cardiovascular Disease	0.2	0.8	2.1	0.4	0.3	-1.4
Angina	0.2	0.2	0.3	0.5	0.5	0.5
Maternal smoking around birth	0.2	0.3	0.7	-0.0	-0.6	-0.9
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.6	-0.1	-0.7
Medication: Atenolol	0.2	0.3	0.8	0.0	-0.0	-0.9
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.1	-0.6	0.6
Trunk fat-free mass	0.2	1.2	2.9	1.7	-0.8	0.3
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.6	0.0	-0.7
Illnesses of mother	0.2	0.2	0.3	0.3	0.5	0.5
Trunk predicted mass	0.2	1.1	2.6	1.6	-0.8	0.3
Medication: Paracetamol	0.2	0.4	1.0	-1.0	0.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	0.2	-0.7	-0.4
Health satisfaction	0.2	0.3	0.5	0.0	-0.5	0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.8	0.4	0.1
Medication: Ibuprofen	0.2	0.2	0.4	-0.2	-0.6	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.4	-0.6	-0.4
Whole body fat-free mass	0.2	1.1	3.0	1.7	-0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.1	-1.0	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	0.6	0.2	0.6
Whole body water mass	0.2	1.0	2.6	1.6	-0.6	0.2
Miserableness	0.2	0.4	1.3	-1.1	-0.1	-0.1
Financial situation satisfaction	0.2	0.3	0.8	-0.2	-0.9	0.2
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.8	0.3	0.2
Fractured/broken bones in last 5 years	0.2	0.3	0.4	0.6	-0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.4	0.3	-0.8
Bipolar Disorder (2018)	0.1	0.2	0.6	0.2	0.0	0.8
Neuroticism (2016)	0.1	0.1	0.4	0.1	0.1	0.6
Blood Platelet Count	0.1	1.7	4.2	-0.3	2.0	1.0
Blood White Count	0.1	0.7	1.0	1.0	0.1	1.0
Lung FEV1/FVC ratio	0.1	0.4	0.5	0.7	-0.5	-0.7
Neuroticism	0.1	0.4	0.9	-0.9	-0.4	-0.2
Number of treatments/medications taken	0.1	0.2	0.5	0.7	0.1	-0.4
Multivitamins +/- minerals	0.1	0.2	0.4	-0.1	0.6	0.4
Stomach or abdominal pain in last month	0.1	0.2	0.4	-0.3	0.6	0.1
High blood pressure (mother)	0.1	0.1	0.3	0.2	-0.3	0.5
Fluid intelligence score	0.1	0.3	0.4	-0.6	0.3	0.7
Neuroticism score	0.1	0.2	0.4	-0.0	0.5	0.6
Mouth/teeth dental problems: Dentures	0.1	0.3	0.6	0.2	0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.3	-0.0	0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	0.3	-0.6	-0.4
Tense / ‘highly strung’	0.1	0.2	0.3	0.6	0.4	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.3	0.3	-0.5
Headache pain in last month	0.1	0.2	0.5	-0.3	0.4	0.7
Medication: Amlodipine	0.1	0.2	0.3	0.5	-0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.2	-0.1	-0.5
High blood pressure (siblings)	0.1	0.2	0.3	-0.6	-0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.3	-0.4	-0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.7	0.3	0.4
Family relationship satisfaction	0.1	0.1	0.3	-0.5	0.3	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.4	-0.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	0.7	0.2	0.1
Osteoporosis (self-reported)	0.1	0.2	0.5	0.7	0.0	0.2
Basal metabolic rate	0.1	0.4	1.1	1.1	-0.1	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.4	-0.2	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.1	0.1	-0.0	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.4	1.0	0.3	0.1	1.0
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.1	-0.2	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.0	0.1	-0.4
Hand grip strength (right)	0.0	0.1	0.2	0.4	-0.4	0.0
Illnesses of siblings	0.0	0.0	0.0	0.0	-0.2	0.0
Arm fat-free mass (right)	0.0	0.1	0.3	0.1	-0.6	-0.1
Arm predicted mass (right)	0.0	0.1	0.3	-0.1	-0.6	-0.3
Arm fat-free mass (left)	0.0	0.2	0.4	-0.0	-0.5	-0.6
Arm predicted mass (left)	0.0	0.1	0.3	-0.0	-0.4	-0.5

Hub : Genes

DUS1L

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Trait associations