TWAS hub - RAC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.093	0.0410	1.0e-02	0.046	-0.002	0.065	0.048	0.065	2.6e-06	0.64	2.2e-08	1.4e-06	2.6e-08
2	GTEx	Heart Left Ventricle	0.166	0.0668	6.6e-03	0.042	NA	0.076	NA	0.074	2.8e-03	NA	7.3e-05	NA	8.7e-05
3	GTEx	Thyroid	0.166	0.0460	6.0e-10	0.118	NA	0.120	NA	0.108	2.7e-09	NA	1.8e-09	NA	1.4e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FVC	6.1	31.2	82.4	9.1	-3.4	-0.1
Hair Pigment	6.0	172.2	432.6	8.2	20.8	-4.1
Birth weight of first child	5.4	9.9	26.1	5.1	-1.9	-0.0
Eye problems/disorders: Cataract	4.4	5.1	12.2	0.4	3.5	-1.7
Ever taken oral contraceptive pill	4.3	4.8	14.0	-3.7	-0.1	0.6
Forced vital capacity (FVC), Best measure	4.1	14.8	37.0	6.1	-1.9	1.9
Nervous feelings	3.9	7.3	20.4	4.5	-0.5	1.1
Eye problems/disorders: None of the above	3.9	4.5	8.8	0.6	-2.1	3.0
Mouth/teeth dental problems: Dentures	3.8	6.5	15.8	4.0	-1.5	-1.2
Average weekly champagne plus white wine intake	3.7	5.1	13.6	-3.7	0.7	-1.1
HbA1C	3.4	3.7	9.1	-3.0	0.8	-1.2
Relative age of first facial hair	3.4	7.0	14.9	0.2	3.9	2.5
Forced vital capacity (FVC)	3.4	13.1	28.9	5.4	-2.8	1.5
Medication: Omeprazole	3.4	4.0	4.8	2.2	1.8	2.0
Number of full sisters	3.4	4.1	10.3	3.2	-1.3	0.4
Leg fat percentage (left)	3.2	11.5	24.1	2.7	-1.7	-4.9
Number of live births	3.1	4.4	7.1	2.7	-2.3	0.9
Leg fat percentage (right)	3.1	11.3	23.0	2.6	-2.0	-4.8
Time employed in main current job	3.0	3.5	7.7	-0.3	-2.8	-1.6
Forced expiratory volume in 1-second (FEV1)	3.0	10.2	23.6	4.9	-1.8	2.0
Lung cancer (father)	3.0	3.5	8.3	-2.9	0.6	-1.3
Heel T-Score	2.9	22.8	48.3	-3.4	-7.0	-2.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.7	21.3	4.6	-0.7	2.1
Shortness of breath walking on level ground	2.7	3.2	7.7	-0.1	-1.3	2.8
Length of working week for main job	2.6	2.9	5.7	-1.1	2.4	1.3
Heart disease (mother)	2.6	3.2	7.9	2.8	0.7	-1.1
Arm fat percentage (right)	2.5	9.7	19.6	3.1	0.1	-4.4
Body fat percentage	2.4	9.3	17.1	3.2	-0.6	-4.1
Arm fat percentage (left)	2.4	9.7	18.8	3.2	0.2	-4.3
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	3.2	1.6	1.7	1.8
Sitting height	2.3	16.0	25.8	4.7	-0.6	5.1
Suffer from ‘nerves’	2.3	3.7	9.2	3.0	-1.3	-0.0
Tinnitus: Yes, now most or all of the time	2.3	2.7	7.0	2.6	-0.3	-1.1
Medication: Co-codamol	2.2	2.6	5.5	2.3	1.5	-0.3
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	7.7	0.1	0.4	-2.8
Body mass index (BMI)	2.2	9.5	20.0	2.9	0.7	-4.5
Waist circumference	2.2	8.0	21.7	1.5	-0.1	-4.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	5.8	-2.4	1.3	0.4
Commuting to job workplace: Walk	2.2	2.4	4.7	1.6	-0.4	2.2
Pain type(s) experienced in last month: Hip pain	2.2	2.8	6.0	1.3	-0.9	2.4
Alzheimer’s Disease (including proxy)	2.1	3.1	6.1	-2.5	1.7	-0.6
Waist Hip Ratio (WHR)	2.1	9.5	17.1	-2.7	-2.0	-4.1
Pulse rate, automated reading	2.1	6.7	11.0	3.0	-3.3	-0.5
Handedness (chirality/laterality): Left-handed	2.1	2.6	4.1	-2.0	0.9	-1.7
Medication: Lisinopril	2.1	2.7	6.5	-1.3	0.2	-2.6
Basal cell carcinoma (self-reported)	2.1	2.5	6.2	-0.4	-2.5	-1.1
BMI	2.0	11.4	24.4	3.0	0.9	-4.9
Chest pain or discomfort	2.0	2.9	8.5	2.9	-0.5	0.0
Arm fat mass (left)	2.0	8.4	12.6	3.6	0.7	-3.5
Trunk fat percentage	1.9	7.5	12.6	3.5	-0.3	-3.1
Mouth/teeth dental problems	1.9	2.9	7.8	-2.8	-0.1	1.0
Pulse wave reflection index	1.9	2.3	3.8	-1.3	2.0	-1.2
Age at first live birth	1.9	3.3	5.9	-2.4	2.0	0.3
Cholesterol lowering medication	1.9	2.8	6.9	0.2	1.2	-2.6
Leg fat mass (left)	1.9	7.2	13.6	2.8	-0.4	-3.7
Alzheimer’s Disease (in mother)	1.8	2.1	5.0	-2.2	1.1	-0.0
Medication: Levothyroxine sodium	1.8	3.0	5.5	-0.7	2.3	-1.8
Arm fat mass (right)	1.8	7.5	12.5	3.1	0.5	-3.5
Peak expiratory flow (PEF)	1.8	4.2	5.9	2.4	1.0	2.4
Leg fat mass (right)	1.8	6.8	12.4	2.8	-0.7	-3.5
Alcohol intake frequency.	1.8	4.1	10.0	3.2	0.9	-1.2
Medication for cholesterol	1.8	2.7	5.3	-0.7	-1.5	2.3
Severe depression (siblings)	1.7	1.9	3.3	1.3	-1.8	0.7
Breastfed as a baby	1.7	2.2	6.4	-0.1	-2.5	-0.3
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.8	2.2	-0.8	-0.8
Migraine (self-reported)	1.6	2.0	4.7	2.2	-1.1	0.4
Whole body fat mass	1.6	6.7	10.4	3.2	-0.1	-3.1
Average weekly red wine intake	1.6	2.3	6.6	-0.6	-0.4	-2.6
Medication: Aspirin	1.6	2.1	4.3	0.8	-1.1	-2.1
Medication: Blood pressure	1.6	3.0	3.3	1.8	1.7	-1.7
Age at First Birth	1.5	2.1	5.0	-2.2	1.2	0.0
Lung FEV1/FVC ratio	1.5	7.5	18.8	-1.8	4.3	0.8
Impedance of leg (right)	1.5	7.5	16.9	-1.3	-4.1	2.0
Qualifications: CSEs or equivalent	1.5	2.0	4.5	1.2	-0.1	-2.1
Trunk fat mass	1.5	6.6	12.0	3.5	0.0	-2.8
Loud music exposure frequency	1.5	1.6	3.6	-0.7	-1.9	0.8
Gout (self-reported)	1.5	2.0	3.1	-1.8	1.2	-1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.6	-1.2	1.6	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.0	0.7	-2.2	-0.1
Medication: Aspirin	1.5	2.0	3.0	0.8	-1.5	-1.7
Wears glasses or contact lenses	1.5	1.7	4.8	0.4	-0.1	-2.2
Risk taking	1.5	2.2	2.8	-1.3	1.5	1.7
Myopia	1.5	2.1	3.7	1.9	0.1	-1.6
Pain experienced in last month	1.5	2.5	3.6	-1.7	1.9	-0.9
Neuroticism (2016)	1.4	2.1	4.8	2.2	-1.2	-0.2
Sensitivity / hurt feelings	1.4	2.4	4.8	2.2	-1.5	-0.4
Vitamin and mineral supplements	1.4	1.8	4.4	-0.6	0.9	-2.1
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.4	-0.2	-1.5	1.6
Serious illness, injury or assault to yourself	1.4	1.8	4.9	-0.0	0.6	2.2
Fluid intelligence score	1.4	3.0	7.5	2.7	-0.9	0.8
Health satisfaction	1.4	1.8	4.6	-0.5	0.7	2.2
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.4	-0.1	-1.5	-2.3
Heart attack	1.3	1.7	4.1	-0.1	0.9	2.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.0	0.1	-0.9	-2.0
Back pain experienced in last month	1.3	1.9	4.4	2.1	-1.2	0.1
Medication: Paracetamol	1.3	1.9	4.4	0.9	-2.1	-0.8
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.8	-0.2	1.1	1.9
Worry (Nagel 2018)	1.2	2.4	6.1	2.5	-1.1	-0.1
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.6	2.1	-1.9	0.4
Chronic bronchitis/emphysema (father)	1.2	1.4	4.1	0.2	0.3	-2.0
Impedance of leg (left)	1.2	6.1	13.7	-1.1	-3.7	1.8
Medication: Simvastatin	1.2	1.8	3.3	-1.2	0.7	-1.8
Hip circumference	1.2	5.0	14.1	3.8	0.4	-0.9
Exposure to tobacco smoke at home	1.2	1.4	1.6	1.3	-1.3	-0.9
Medication: Blood pressure	1.2	2.1	2.6	-1.4	1.4	-1.6
Crohns Disease (2017)	1.1	2.4	5.6	-0.8	-2.4	-1.0
Irritable Bowel Disease (IBD)	1.1	2.7	6.5	-0.7	-2.5	-1.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	3.9	0.6	2.0	0.3
Hearing difficulty/problems with background noise	1.1	1.7	2.3	1.5	-0.7	1.5
Medication: Cholesterol lowering	1.1	1.7	3.2	-1.8	-0.4	-1.3
Medication: Amlodipine	1.1	1.6	2.9	0.8	-1.7	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.6	-0.8	-1.6	-0.7
Qualifications: College or University degree	1.1	3.5	8.7	-2.9	1.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.5	1.9	0.6	0.1
Leg fat-free mass (right)	1.1	5.6	8.9	2.8	3.0	0.4
Qualifications: nursing, teaching	1.1	1.7	3.5	-1.9	1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	5.8	2.4	0.4	0.8
Leg predicted mass (right)	1.1	5.7	9.1	2.8	3.0	0.4
Commuting to job workplace: Public transport	1.1	1.3	2.2	-1.5	0.4	1.2
Ever depressed for a whole week	1.1	1.3	3.5	-0.0	-0.6	1.9
Commuting to job workplace: Cycle	1.1	1.3	3.2	-0.9	0.0	1.8
Alzheimer’s Disease (in father)	1.0	1.1	1.4	-0.9	1.1	-1.2
Height	1.0	19.6	58.8	0.3	-0.2	7.7
Cardiovascular Disease	1.0	3.2	4.5	1.5	1.7	-2.1
Systolic blood pressure, automated reading	1.0	2.8	5.6	2.4	1.6	-0.7
Supplements: Zinc	1.0	1.1	2.2	-0.9	-1.5	-0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.3	1.8	0.0	-0.9
Weight	1.0	5.2	11.0	3.3	0.7	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.5	1.6	-1.0	1.2
Hair/balding pattern: Pattern 3	1.0	1.4	2.9	-0.1	-1.7	-1.2
Birth weight	1.0	2.3	5.4	2.3	0.8	0.9
Medication for pain relief, constipation, heartburn	1.0	1.7	2.4	-1.6	1.4	1.0
Medication: Ibuprofen	1.0	1.2	2.4	0.3	-1.6	-1.0
Medication: Allopurinol	1.0	1.3	2.0	-1.1	1.4	-0.8
Supplements: Vitamin C	1.0	1.2	2.6	0.3	-0.9	1.6
Mood swings	1.0	1.9	2.8	1.0	1.3	1.7
Diabetes diagnosed by doctor	1.0	1.7	3.1	-0.7	-1.2	-1.8
Osteoarthritis (self-reported)	1.0	1.3	3.1	-0.1	1.0	-1.8
Medication: Bendroflumethiazide	1.0	1.5	3.4	0.9	-0.2	-1.9
Number of operations (self-reported)	1.0	1.5	4.2	0.0	2.1	0.5
Smoking Status	0.9	2.2	2.8	-1.7	0.9	-1.7
Tanning	0.9	11.3	18.6	-2.6	-4.3	2.9
Average weekly spirits intake	0.9	1.2	2.0	-1.4	-1.2	-0.3
Leg fat-free mass (left)	0.9	4.9	8.7	3.0	2.4	0.2
Hand grip strength (right)	0.9	2.4	3.5	-0.6	1.9	1.9
Taking other prescription medications	0.9	1.3	3.8	0.2	2.0	0.3
Leg predicted mass (left)	0.9	4.9	8.9	3.0	2.4	0.2
Alcohol usually taken with meals	0.9	1.5	4.0	0.2	-0.6	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.2	1.4	0.6	1.5
Standing height	0.9	9.4	26.6	1.2	0.1	5.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.4	1.6	-0.8	1.2
Number of full brothers	0.9	1.1	2.5	1.6	-0.8	0.3
Had major operations	0.9	1.0	1.9	-0.6	0.8	1.4
Hypertension (Self-reported)	0.9	2.6	5.6	0.3	1.4	-2.4
Long-standing illness, disability or infirmity	0.9	1.3	2.2	1.5	0.6	1.2
Asthma (self-reported)	0.9	1.8	2.7	0.2	1.6	1.6
Fractured/broken bones in last 5 years	0.9	1.1	2.6	1.6	0.6	0.7
Diastolic blood pressure, automated reading	0.9	2.7	4.7	1.5	1.1	-2.2
Unable to work because of sickness or disability	0.9	1.2	2.1	1.1	-0.6	1.5
Impedance of whole body	0.9	4.4	7.7	-0.2	-2.8	2.3
Neuroticism (Nagel 2018)	0.8	1.9	3.9	2.0	-1.0	-0.9
Chronotype (morning person)	0.8	1.8	2.2	1.5	-1.4	-1.2
Hand grip strength (left)	0.8	2.2	2.8	-1.2	1.7	1.5
Medication: Metformin	0.8	1.2	1.8	-1.3	-0.2	-1.3
Father’s age at death	0.8	1.0	3.1	-0.0	0.0	1.8
Falls in the last year	0.8	1.1	3.1	0.2	0.5	1.8
Qualifications: A levels/AS levels or equivalent	0.8	1.7	5.1	-2.2	-0.1	-0.2
Smoking status: Previous	0.8	1.2	3.3	-0.6	0.0	-1.8
Loneliness, isolation	0.8	1.1	2.5	-0.6	-1.6	0.5
Ever had bowel cancer screening	0.8	0.9	2.7	-0.1	0.2	-1.6
Breast cancer (self-reported)	0.8	1.0	1.9	0.7	1.4	0.7
High cholesterol (Self-reported)	0.8	1.3	3.9	-0.1	-0.2	-2.0
Alcohol drinker status: Never	0.8	1.0	1.4	1.2	1.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.8	-1.3	0.2	-0.8
Maternal smoking around birth	0.7	1.0	1.4	0.9	1.2	-0.9
High blood pressure	0.7	2.1	4.7	0.3	1.2	-2.2
Had menopause	0.7	0.9	2.0	-0.2	1.4	-0.8
Had other major operations	0.7	0.8	1.2	1.1	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.3	-1.5	-1.4	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.5	0.2	-0.3	1.6
Pain all over the body in last month	0.7	0.7	1.1	1.0	-0.3	-1.0
Neuroticism score	0.7	1.4	3.8	1.9	-0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	0.0	-0.5	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.1	0.5	-1.4	-0.4
Depression (self-reported)	0.7	0.8	2.3	0.1	-0.4	1.5
Impedance of arm (left)	0.7	3.2	7.3	0.1	-1.5	2.7
Medication: Paracetamol	0.7	1.1	2.0	1.1	-1.4	-0.5
Osteoporosis (self-reported)	0.7	0.8	1.2	1.1	0.1	1.1
Smoking status: Current	0.7	1.1	2.7	-0.6	1.6	0.5
Number of self-reported non-cancer illnesses	0.7	1.2	3.7	0.1	1.9	0.0
Guilty feelings	0.7	1.0	2.8	-0.3	-0.5	-1.7
Mother’s age at death	0.7	0.9	1.8	-0.2	-1.4	-0.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.7	-1.1	1.3	0.0
Bipolar Disorder (2018)	0.6	0.9	1.7	-1.0	0.0	1.3
Ulcerative Colitis (UC)	0.6	1.0	2.7	-0.0	-1.6	-0.7
Prostate Cancer	0.6	0.8	1.9	-1.4	0.5	0.4
Lupus	0.6	0.9	1.5	-1.0	-0.3	1.2
Rheumatoid Arthritis	0.6	0.8	1.2	1.1	-0.9	-0.6
Neuroticism	0.6	1.4	3.1	1.8	-0.7	-0.8
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.8	1.4	-0.7	0.5
Relative age voice broke	0.6	0.9	2.3	0.1	1.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	1.5	-1.2	-1.2	-1.2
Past tobacco smoking	0.6	1.1	2.9	0.4	-0.5	1.7
Financial difficulties in last 2 years	0.6	0.9	1.5	-0.8	0.7	1.2
Diabetes (self-reported)	0.6	1.0	1.6	-1.3	-0.6	-1.0
Worrier / anxious feelings	0.6	1.1	1.3	1.1	-1.0	-1.0
Asthma	0.6	1.3	2.1	0.5	1.4	1.2
Hair/balding pattern: Pattern 4	0.6	1.6	3.8	0.3	-1.9	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.0	-0.3	1.4	-1.2
High blood pressure (siblings)	0.6	0.9	1.8	1.4	0.2	-0.9
Worry too long after embarrassment	0.6	1.0	1.9	1.4	-1.0	-0.1
Pulse wave peak to peak time	0.6	0.7	1.2	0.3	-0.9	1.1
Comparative height size at age 10	0.6	3.3	9.4	0.7	-0.2	3.1
Illnesses of father: Heart disease	0.6	0.8	1.2	-0.6	-1.1	0.9
Whole body fat-free mass	0.6	3.3	5.3	2.1	2.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	0.9	-0.6	1.0	0.9
Whole body water mass	0.6	3.4	5.8	2.1	2.4	0.3
Basal metabolic rate	0.6	3.5	6.8	2.6	1.9	-0.0
Arm fat-free mass (left)	0.6	2.8	5.9	2.4	1.5	-0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	0.8	0.9	-0.8	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.0	-0.6	-1.2	1.7
Reaction Time	0.5	1.0	2.3	0.0	-0.8	1.5
Breast Cancer	0.5	1.2	2.7	0.2	-1.6	0.9
Schizophrenia (2014)	0.5	1.1	3.2	0.4	0.0	1.8
Systolic Blood Pressure	0.5	2.3	4.6	2.1	1.5	0.4
Respiratory disease	0.5	1.2	2.5	-0.3	1.0	1.6
Hearing difficulty/problems: Yes	0.5	0.7	0.8	0.8	-0.9	0.8
Pack years adult smoking proportion	0.5	0.7	1.8	-0.1	1.3	-0.6
Age when periods started (menarche)	0.5	1.1	3.2	-0.1	0.3	1.8
Medication: Atenolol	0.5	0.6	1.2	0.3	1.1	-0.7
Number of incorrect matches in round	0.5	0.8	1.5	0.7	-0.5	1.2
Alcohol intake versus 10 years previously	0.5	0.7	1.0	1.0	0.8	-0.7
Tense / ‘highly strung’	0.5	0.8	1.0	0.8	0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.0	0.3	-0.4	-1.4
Arm fat-free mass (right)	0.5	2.6	5.2	2.3	1.6	-0.0
Number of children fathered	0.5	0.6	1.4	-0.1	-1.2	-0.6
Mean time to correctly identify matches	0.5	1.0	1.5	-0.0	-1.2	1.2
Arm predicted mass (right)	0.5	2.7	5.2	2.3	1.7	-0.1
Overall health rating	0.5	1.1	2.7	1.6	-0.1	0.8
Family relationship satisfaction	0.5	0.6	1.2	-0.7	0.1	1.1
Knee pain experienced in last month	0.5	0.8	1.5	-0.3	-0.8	1.2
Medication: Gliclazide	0.5	0.6	1.3	-0.6	-1.1	-0.4
Irritability	0.5	0.9	1.7	-0.2	1.0	1.3
Arm predicted mass (left)	0.5	2.7	5.2	2.3	1.7	-0.3
Ovarian Cancer	0.4	0.6	0.9	-1.0	-0.3	-0.8
Fasting Glucose	0.4	0.5	1.1	-0.5	-0.3	-1.1
Hypothyroidism (self reported)	0.4	1.0	2.7	-0.1	1.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	0.4	-0.0	-1.1
Current tobacco smoking	0.4	0.7	1.8	-0.1	1.3	0.6
Medication: Ramipril	0.4	0.6	1.0	-0.3	1.0	-0.7
Illnesses of siblings	0.4	0.5	0.7	-0.8	-0.7	0.6
Impedance of arm (right)	0.4	2.1	4.3	0.0	-1.4	2.1
Trunk fat-free mass	0.4	2.1	3.8	1.4	2.0	0.8
Trunk predicted mass	0.4	2.2	3.9	1.4	2.0	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	1.1	-0.5	0.3
Wheeze or whistling in the chest in last year	0.4	0.8	2.0	1.4	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	0.7	0.0	1.5
Friendships satisfaction	0.4	0.5	1.3	-0.3	-1.1	-0.4
Financial situation satisfaction	0.4	0.5	1.0	-0.7	0.2	1.0
Ever smoked	0.4	0.6	1.0	-0.9	0.3	-1.0
Age started oral contraceptive pill	0.4	0.6	1.2	-0.2	1.1	-0.6
Supplements: Calcium	0.4	0.5	1.0	0.3	1.0	0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	-0.3	0.0	1.5
Diabetes (father)	0.3	0.3	0.4	-0.6	0.4	-0.6
Fed-up feelings	0.3	0.5	1.3	1.1	-0.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.5	0.2	-0.7	0.7
Multivitamins +/- minerals	0.3	0.3	0.8	0.2	-0.4	0.9
High blood pressure (mother)	0.3	0.5	1.3	1.2	-0.2	0.2
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	0.8	0.6	-0.0
Pulse rate	0.3	0.6	1.0	1.0	-0.3	-0.8
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	-0.0	0.8	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.6	0.2	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	-0.6	-1.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.3	0.8	-0.7
Headache pain in last month	0.3	0.5	1.1	-0.1	1.0	0.5
Glaucoma (self-reported)	0.3	0.4	0.5	-0.7	0.3	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	-0.6	0.6	0.7
Comparative body size at age 10	0.3	0.7	1.2	-0.3	-1.1	-0.9
Age at last live birth	0.3	0.4	0.8	-0.9	0.6	-0.2
Leg pain on walking	0.3	0.4	0.9	-0.2	0.9	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	-0.2	0.5	-0.9
Hearing aid user	0.3	0.3	0.7	-0.1	0.5	-0.8
Medication: Atorvastatin	0.3	0.3	0.9	0.0	-0.3	-1.0
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.6	0.8	0.5
Pack years of smoking	0.3	0.5	1.0	-0.4	1.0	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.0	0.0	0.8
Mean Putamen Volume	0.2	0.2	0.4	0.7	-0.2	0.4
Blood Eosinophil Count	0.2	1.7	2.9	-0.9	1.7	-1.1
Blood Red Count	0.2	1.9	2.6	1.6	-1.1	-1.4
Blood White Count	0.2	1.2	2.2	1.5	1.0	0.5
Allergy or Eczema	0.2	0.5	0.8	-0.7	-0.5	-0.9
Number of treatments/medications taken	0.2	0.3	1.0	-0.1	1.0	0.0
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.1	-0.3	-0.8
Diabetes (mother)	0.2	0.3	0.5	-0.6	-0.0	-0.7
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.9	-0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.6	-0.1	-0.8
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.5	-0.4	-0.4
Qualifications: None of the above	0.2	0.4	0.8	0.3	-0.5	-0.9
Allergy	0.2	0.4	0.7	-0.8	0.6	0.2
Noisy workplace	0.2	0.2	0.4	-0.6	0.3	-0.5
Exposure to tobacco smoke outside home	0.2	0.2	0.4	-0.2	-0.6	0.4
Neck or shoulder pain in last month	0.2	0.3	0.8	0.4	-0.0	0.9
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.2	0.4	-0.8
Miserableness	0.2	0.4	1.1	1.0	-0.4	-0.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.6	-0.2	0.4
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.3	0.7	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.1	-0.0	-0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.7	-0.3	-0.5
Depression (Nagel 2018)	0.1	0.2	0.4	0.6	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	1.0	-0.2	-0.2
Schizophrenia (2018)	0.1	0.2	0.5	0.0	0.0	0.7
Blood Platelet Count	0.1	1.4	1.9	1.4	1.2	0.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.2	0.3	0.3
Angina	0.1	0.2	0.5	-0.2	0.7	0.0
Average weekly fortified wine intake	0.1	0.2	0.3	-0.2	0.3	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.2	0.4	-0.2
Happiness	0.1	0.1	0.2	0.3	-0.0	0.5
Medication: Lansoprazole	0.1	0.1	0.2	0.1	0.1	0.4
Prospective memory result	0.1	0.1	0.2	-0.1	-0.3	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.2	-0.6	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.1	-0.6	-0.1
Angina (self-reported)	0.1	0.1	0.2	0.2	0.5	0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.6	0.0	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.5	0.2	0.0
Mineral and other dietary supplements	0.1	0.2	0.3	0.5	-0.5	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.1	-0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.4	-0.5	-0.1
Heart disease (siblings)	0.1	0.1	0.2	0.1	0.5	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	-0.2
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	-0.2	-0.1
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.1	0.0	0.0	-0.3
Supplements: Glucosamine	0.0	0.0	0.1	0.1	-0.1	0.2
Illnesses of mother	0.0	0.0	0.1	0.0	-0.1	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	0.3	0.1	0.1

Hub : Genes

RAC3

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Trait associations