[Hub]/) : Traits : Heel T-Score : ← →

chr1:21,140,385-24,584,490

Best TWAS P=9.87e-105 · Best GWAS P=3.42e-155 conditioned to 2.07e-60

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALPL	0.08	0.03	enet	6	0.02	4.2e-03	2.723	5.7	1.4e-08	-0.02	0.78	0.01	TRUE
2	GTEx	Adipose Visceral Omentum	RP1-224A6.9	0.11	0.02	enet	16	0.05	1.7e-03	6.064	7.5	9.6e-14	-0.04	0.19	0.05	TRUE
3	GTEx	Artery Aorta	ZNF436	0.43	0.34	enet	17	0.39	1.3e-22	4.549	5.7	1.5e-08	0.00	0.94	0.05	FALSE
4	GTEx	Brain Caudate basal ganglia	LINC00339	0.43	0.16	enet	37	0.25	7.5e-08	-0.095	-7.8	6.2e-15	-0.24	0.59	0.03	TRUE
5	GTEx	Brain Hippocampus	LINC00339	0.41	0.08	lasso	8	0.13	5.1e-04	7.596	5.2	2.3e-07	-0.10	0.15	0.05	TRUE
6	GTEx	Breast Mammary Tissue	ZNF436	0.25	0.14	enet	14	0.16	1.9e-08	4.549	5.6	2.3e-08	0.03	0.93	0.06	FALSE
7	GTEx	Cells Transformed fibroblasts	USP48	0.14	0.00	lasso	5	0.01	7.4e-02	-2.993	-5.5	4.5e-08	0.07	0.21	0.14	FALSE
8	GTEx	Cells Transformed fibroblasts	TCEA3	0.33	0.19	lasso	4	0.22	2.6e-16	3.534	-5.5	3.6e-08	0.03	0.85	0.15	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	ZNF436	0.37	0.14	enet	13	0.23	6.2e-09	4.549	6.1	1.2e-09	0.00	0.72	0.27	TRUE
10	GTEx	Esophagus Mucosa	ZNF436	0.17	0.09	lasso	4	0.12	1.6e-08	4.549	5.7	1.1e-08	-0.01	0.62	0.36	FALSE
11	GTEx	Nerve Tibial	USP48	0.12	0.06	lasso	5	0.07	9.6e-06	4.840	-6.6	4.4e-11	-0.02	0.92	0.00	TRUE
12	GTEx	Ovary	ZNF436	0.42	0.05	lasso	4	0.18	3.2e-05	4.549	5.4	8.3e-08	0.01	0.47	0.23	FALSE
13	GTEx	Pancreas	ZNF436	0.71	0.50	lasso	7	0.48	5.8e-23	4.549	5.2	1.7e-07	0.00	0.94	0.06	FALSE
14	GTEx	Thyroid	USP48	0.40	0.29	lasso	3	0.38	5.4e-31	7.021	6.1	1.2e-09	0.02	1.00	0.00	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	CDC42	0.07	0.02	lasso	6	0.04	5.7e-06	12.089	6.6	3.9e-11	-0.03	0.88	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	C1orf213	0.11	0.10	lasso	2	0.09	8.7e-12	5.640	-5.6	2.0e-08	0.03	0.09	0.91	FALSE
17	YFS	Blood	ID3	0.07	0.02	lasso	10	0.04	8.4e-13	-5.895	-6.0	2.1e-09	0.04	0.00	1.00	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	USP48	0.03	0.02	blup	86	0.02	1.3e-04	-2.275	-5.3	1.2e-07	0.00	0.81	0.07	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	WNT4	0.03	0.01	blup	72	0.02	3.8e-05	-16.800	-21.7	9.9e-105	0.09	0.04	0.93	TRUE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALPL	0.04	0.01	blup	108	0.02	1.7e-03	-6.815	7.6	3.1e-14	-0.08	0.11	0.07	TRUE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	USP48	0.03	0.02	blup	86	0.01	1.0e-02	8.290	-8.9	5.6e-19	-0.03	0.12	0.09	TRUE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	WNT4	0.05	0.01	blup	69	0.01	1.1e-02	-9.337	14.5	1.5e-47	-0.05	0.03	0.20	TRUE
23	The Cancer Genome Atlas	Rectum Adenocarcinoma	LDLRAD2	0.20	0.01	blup	38	0.04	4.2e-02	-0.668	7.2	4.6e-13	-0.02	0.00	0.23	TRUE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF436	0.05	0.04	enet	6	0.05	1.1e-04	4.216	5.4	6.1e-08	-0.01	0.03	0.89	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	USP48	0.12	0.10	lasso	5	0.13	1.4e-12	3.286	5.8	5.9e-09	0.01	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	WNT4	0.14	0.06	blup	70	0.12	9.7e-12	4.227	13.8	1.5e-43	-0.13	0.32	0.68	TRUE
27	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF436	0.05	0.04	enet	5	0.05	1.0e-05	4.662	5.5	4.0e-08	0.01	0.19	0.50	FALSE