Hub : Genes

USP48

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0220	2.9e-03	0.000	0.023	0.007	0.02	0.003	2.9e-01	7.4e-04	3.7e-02	0.0016	1.1e-01
2	GTEx	Artery Tibial	0.1004	0.0334	1.0e-03	0.036	NA	0.024	NA	0.029	8.2e-04	NA	5.1e-03	NA	2.3e-03
3	GTEx	Cells Transformed fibroblasts	0.1400	0.0470	3.1e-03	-0.004	NA	0.007	NA	0.008	9.3e-01	NA	9.0e-02	NA	7.4e-02
4	GTEx	Esophagus Muscularis	0.2070	0.0600	3.7e-04	0.001	NA	-0.004	NA	0.004	2.6e-01	NA	7.0e-01	NA	1.9e-01
5	GTEx	Nerve Tibial	0.1230	0.0439	2.2e-03	0.063	NA	0.054	NA	0.071	2.9e-05	NA	1.0e-04	NA	9.6e-06
6	GTEx	Thyroid	0.3950	0.0530	0.0e+00	0.286	NA	0.365	NA	0.384	3.7e-22	NA	3.6e-29	NA	5.4e-31
7	TCGA	Breast Invasive Carcinoma	0.0311	0.0122	5.1e-05	0.015	0.017	0.011	NA	0.011	3.3e-04	1.3e-04	1.9e-03	NA	2.2e-03
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0341	0.0171	2.5e-03	0.022	0.013	0.006	NA	0.012	1.4e-03	1.0e-02	5.7e-02	NA	1.3e-02
9	TCGA	Pheochromocytoma and Paraganglioma	0.1850	0.1030	1.7e-03	0.020	0.043	0.057	NA	0.039	5.2e-02	8.2e-03	2.7e-03	NA	1.1e-02
10	TCGA	Thyroid Carcinoma	0.1250	0.0410	5.8e-11	0.103	0.101	0.099	NA	0.129	3.0e-10	5.3e-10	7.4e-10	NA	1.4e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.5	1.0	-0.1	0.8	-0.6	-1.0	-0.2	-0.7	0.6	0.9	0.8	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.2	3.4	-0.7	-1.8	-1.7	-1.4	-0.9	-0.1	-1.4	-0.7	-0.4	-0.2
Depressed Affect (Nagel 2018)	0.5	1.1	3.3	-1.4	-1.3	-1.3	-0.2	-1.3	0.7	-1.8	-0.2	-0.8	0.2
Depression (Nagel 2018)	1.9	2.9	9.8	-1.3	-2.5	-1.6	-0.5	-1.7	0.7	-3.1	-1.0	-1.9	0.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.2	0.6	0.5	2.0	-0.0	0.2	-1.4	-0.2	0.0	0.8	-1.4
Neuroticism (Nagel 2018)	1.2	2.8	6.9	-2.3	-1.8	-1.8	-0.9	-1.8	0.7	-2.6	-0.3	-2.1	0.3
Schizophrenia (2018)	1.2	2.5	9.3	-0.7	-3.0	-1.7	-0.9	-1.0	0.4	-2.3	-1.7	-1.5	0.3
Schizophrenia vs Biploar Disorder	1.6	2.1	5.3	-0.9	-2.0	-0.5	-1.0	-1.9	0.8	-2.3	-1.8	-1.1	0.6
Worry (Nagel 2018)	1.8	3.9	12.0	-2.9	-2.2	-1.5	-0.4	-1.9	0.9	-2.6	-0.3	-3.5	0.8
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.2	0.7	0.3	0.6	-0.4	-0.1	-0.8	-0.7	0.7	0.1
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.1	-1.0	0.2	-0.5	-0.8	0.5	-1.0	-0.9	0.2	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.1	0.3	0.9	0.2	-0.9	0.7	-0.5	-0.8	0.8	0.8
Crohns Disease (2017)	0.5	1.2	3.9	0.1	1.4	1.3	-0.5	0.2	1.5	0.8	-0.8	-0.8	2.0
Irritable Bowel Disease (IBD)	0.3	0.8	2.0	-1.3	0.5	0.5	-0.8	0.4	1.2	0.6	-0.6	-0.6	1.4
Ulcerative Colitis (UC)	0.3	0.6	4.6	-2.1	-0.4	-0.0	-0.8	0.4	0.1	0.0	-0.3	0.4	0.2
Major Depression (MDD)	0.5	0.6	1.7	1.3	-0.8	0.5	0.6	-0.2	-1.0	-0.2	0.4	0.0	-1.1
Reaction Time	1.9	3.7	8.6	-2.9	-0.3	-0.7	-1.2	-1.6	2.7	-0.0	-1.5	-2.5	2.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.4	0.3	0.0	1.2	0.1	0.7	-1.6	-0.2	0.4	0.3	-1.5
Breast Cancer	0.6	1.5	4.0	-0.1	1.4	0.8	-1.0	0.2	-1.8	0.6	1.5	1.1	-2.0
Ovarian Cancer	0.8	1.1	1.9	1.2	0.8	1.1	-0.4	1.4	-1.3	0.6	1.3	0.3	-1.3
Prostate Cancer	0.8	1.1	2.9	-0.1	0.7	0.1	-0.7	-1.3	1.4	-0.4	-1.6	-0.5	1.7
Age at First Birth	0.7	1.0	2.4	0.0	-0.1	1.2	-1.1	0.5	-1.5	-0.8	1.1	0.4	-1.6
Bipolar Disorder (2011)	0.5	0.5	2.3	-0.5	-0.4	0.1	-1.5	-0.3	0.7	-0.4	-0.5	-0.4	0.9
Body Mass Index (BMI) (2010)	0.2	0.3	1.7	-0.1	-0.0	0.2	-0.2	0.3	0.4	0.8	0.5	1.3	0.2
Coronary Artery Disease (CAD)	0.5	0.7	2.2	0.8	-0.2	0.7	-0.3	1.0	-0.7	1.0	1.5	0.2	-0.8
Crohns Disease (2012)	1.7	2.7	8.5	-1.4	-0.2	0.5	-0.9	-1.2	2.6	-0.7	-2.3	-1.3	2.9
Mean Putamen Volume	4.5	5.1	12.0	-3.3	0.3	-0.3	-1.1	-1.7	3.1	0.8	-2.0	-3.0	3.5
Fasting Glucose	0.2	0.2	1.3	0.1	-0.5	0.1	0.4	-0.1	-0.5	-1.1	-0.2	0.2	-0.6
HbA1C	0.5	0.6	1.3	1.0	-1.1	1.2	0.9	0.8	0.4	-0.5	-0.5	-0.5	0.5
HDL Cholesterol	0.3	0.4	1.2	0.9	1.1	0.6	-0.5	-0.2	-0.1	1.0	0.3	0.6	-0.0
LDL Cholesterol	0.8	1.3	3.8	-1.9	-0.3	-0.1	-0.9	-0.3	1.8	0.9	-0.3	-0.2	2.0
Lupus	0.8	1.3	5.0	-0.2	0.5	0.1	2.0	2.2	-0.1	1.4	1.2	0.1	0.4
Neuroticism (2016)	0.3	0.4	1.0	-0.5	0.5	-1.0	0.5	-0.6	-0.0	0.5	0.8	-0.9	-0.1
Primary Biliary Cirrhosis	0.6	0.8	2.3	0.4	1.4	1.3	-1.0	-0.0	0.4	1.5	0.6	0.5	0.2
Rheumatoid Arthritis	0.3	0.4	1.1	0.2	0.4	0.4	0.9	0.9	-0.6	0.1	1.1	0.4	-0.6
Schizophrenia (2014)	1.3	2.8	6.1	-1.0	-2.4	-1.5	-1.6	-1.6	0.9	-2.5	-2.1	-1.2	0.8
Triglycerides	0.4	0.7	2.8	-0.9	-0.6	-0.1	-1.7	-0.2	0.7	0.7	-0.5	-0.1	1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.7	-0.8	-0.2	-0.1	0.3	-0.0	-0.5	0.7	0.3	-0.5
Ulcerative Colitis	0.4	0.6	1.5	-0.9	-0.4	-0.2	0.9	1.2	-0.7	0.4	0.6	1.0	-0.6
Blood Eosinophil Count	0.3	2.4	7.0	2.6	1.7	0.9	1.4	2.1	-1.0	1.5	1.2	0.7	-1.3
Blood Platelet Count	0.1	1.7	4.3	0.6	1.6	1.4	0.9	1.9	-0.1	2.1	1.9	-0.2	-0.2
Blood Red Count	0.6	6.0	29.6	-5.4	-2.5	-0.4	-2.5	-2.0	1.9	-1.0	-1.9	-1.3	2.0
Blood White Count	0.1	1.0	3.7	1.9	1.8	0.6	-0.3	-0.1	-0.5	0.6	0.5	1.5	-0.3
Heel T-Score	3.4	27.1	79.2	3.7	1.6	-5.5	-1.6	-6.6	6.1	-5.3	-8.9	-0.5	5.8
BMI	0.3	1.6	4.3	0.9	2.1	-0.5	-0.1	-0.4	1.7	1.5	-1.4	-0.4	1.9
Height	0.2	4.1	10.8	-2.8	2.1	3.3	-1.0	2.1	-0.6	1.3	1.5	-2.8	-0.4
Waist Hip Ratio (WHR)	0.5	2.5	5.6	-0.3	-2.3	1.1	-0.6	0.2	2.1	-0.2	-1.8	-2.1	2.4
Systolic Blood Pressure	0.5	2.7	13.5	-2.4	-3.7	0.4	0.4	0.0	0.1	-1.6	-1.1	-1.9	0.1
Smoking Status	0.9	2.2	5.7	2.2	-0.4	-0.2	1.8	-0.1	-2.4	-1.1	1.2	0.3	-2.4
Allergy or Eczema	0.4	1.1	4.8	-0.1	2.2	-0.3	0.2	0.6	0.5	1.8	1.3	-0.3	0.6
Cardiovascular Disease	0.4	1.3	2.6	-1.6	-1.1	0.9	-0.2	-1.2	1.5	-0.2	-1.3	-0.6	1.6
Hypothyroidism (self reported)	2.0	4.6	10.9	-1.2	-0.5	-0.1	-0.6	-2.5	2.6	-1.8	-3.0	-3.3	2.8
Respiratory disease	0.2	0.5	1.9	1.3	1.1	-0.1	0.1	-0.2	0.1	1.4	0.6	-0.0	-0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.9	0.0	1.0	0.5	-0.7	-0.9	1.3	0.7	-1.7	-1.0	1.4
Lung FEV1/FVC ratio	0.8	4.1	14.7	-3.8	-2.8	-0.7	-0.5	-0.3	2.1	-0.6	-2.5	-0.6	2.6
Lung FVC	0.5	2.6	5.5	-2.1	-2.3	0.8	-1.5	-1.8	-1.0	-2.3	-1.4	-0.1	-1.2
Neuroticism	0.8	1.9	5.5	-1.9	-1.2	-1.3	-1.0	-1.6	0.1	-2.4	-0.1	-1.7	-0.2
Chronotype (morning person)	1.1	2.5	5.4	-1.3	1.4	1.1	-2.3	-0.9	2.2	1.9	0.4	-0.9	2.0
Hair Pigment	0.0	0.4	1.2	0.0	-1.1	0.9	-0.3	0.5	-0.1	0.5	1.0	0.4	-0.2
Tanning	0.2	1.9	3.8	0.7	1.6	-0.2	1.4	1.1	-1.7	1.5	1.8	0.7	-1.9
Hand grip strength (left)	0.3	0.9	2.0	1.3	-0.9	1.4	-0.6	-0.0	-0.1	-1.4	-1.1	-0.6	-0.1
Number of treatments/medications taken	1.1	2.0	5.7	-1.0	1.4	0.5	0.1	-0.8	2.4	2.1	-0.3	-1.3	2.0
Average weekly spirits intake	0.7	0.9	4.0	0.9	1.0	-1.0	1.1	0.2	-0.1	0.7	0.4	2.0	0.1
Sensitivity / hurt feelings	0.5	0.8	3.2	0.4	-0.2	-0.6	0.5	-0.2	-1.5	-1.0	0.9	0.1	-1.8
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.8	-0.9	-0.5	-0.7	-0.6	-1.6	1.2	-1.6	-1.3	-1.9	0.9
Hearing difficulty/problems: Yes	0.8	1.2	3.2	-0.8	-0.2	-1.4	-1.5	-1.8	1.2	-0.9	-0.7	-0.6	1.2
Relative age of first facial hair	0.3	0.6	1.7	1.3	1.0	0.6	-0.7	0.1	-0.2	0.7	1.3	-0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.9	-0.9	0.8	0.1	0.6	-1.2	1.7	0.3	-1.5	-0.9	1.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.4	-0.9	-1.0	-0.3	-0.5	-0.3	0.2	-0.1	0.6	-0.3
Ever had hysterectomy (womb removed)	0.2	0.2	1.0	0.2	-0.1	-0.5	0.0	-0.4	0.2	0.1	-1.0	0.4	0.3
Systolic blood pressure, automated reading	0.8	2.3	7.9	-2.2	-2.8	-0.6	-1.5	-0.8	0.9	-1.2	-1.3	-1.4	0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.8	-1.6	-0.4	-0.3	0.7	0.7	1.6	1.1	-1.2	-0.7	1.7
Angina	0.6	0.8	1.6	1.0	0.7	1.1	1.0	1.0	-0.4	1.3	1.2	0.5	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.9	-0.6	-0.7	0.9	0.1	0.1	-0.0	0.5	0.6	-0.3	-0.2
Vitamin and mineral supplements	2.0	2.7	5.1	-1.5	-2.2	-0.4	-1.2	-1.6	1.6	-2.2	-2.0	-1.1	1.7
Supplements: Zinc	1.9	2.1	4.8	0.4	0.4	0.9	0.9	2.2	-1.6	2.2	1.8	1.3	-1.3
Medication: Co-codamol	0.4	0.4	1.0	0.1	1.0	-0.9	0.4	0.2	-0.0	0.8	0.7	1.0	-0.1
Medication: Metformin	0.6	0.9	2.0	-0.9	0.7	0.1	-0.9	-1.2	1.0	0.6	-1.4	-0.5	1.2
Diabetes (father)	0.7	0.8	5.2	-0.7	0.4	0.9	-0.9	-0.0	0.4	0.3	0.5	-2.3	0.5
Diabetes (mother)	1.6	2.0	5.3	-0.4	0.0	-0.9	-2.3	-1.9	0.7	-1.5	-1.8	-1.8	1.0
Severe depression (siblings)	0.9	1.1	2.1	1.3	-0.2	-0.8	1.2	1.3	-1.5	0.3	0.9	0.5	-1.3
Pack years adult smoking proportion	0.5	0.8	1.8	1.2	1.3	-0.6	1.1	0.4	-0.6	0.8	0.8	0.2	-1.1
Impedance of leg (right)	0.2	0.9	4.5	0.1	-0.3	0.1	-0.3	-0.6	1.5	0.1	0.2	-2.1	1.3
Leg fat-free mass (left)	0.1	0.4	1.2	-0.3	1.1	0.7	0.4	0.7	-0.8	0.3	-0.8	0.5	-0.5
Trunk fat percentage	0.4	1.6	4.5	0.0	0.6	2.1	-0.6	-0.7	1.8	0.1	-1.4	-1.4	1.8
Hand grip strength (right)	0.4	1.0	2.2	0.8	-0.9	1.4	-1.0	-0.1	0.3	-1.4	-1.5	-1.0	0.5
Townsend deprivation index at recruitment	1.1	1.5	5.9	2.4	0.9	-0.7	1.5	1.4	-1.3	0.5	0.2	0.5	-1.1
Current tobacco smoking	0.6	1.0	2.7	1.0	-0.5	-1.0	0.4	-1.6	-0.3	-1.6	-1.3	-0.9	-0.4
Average weekly fortified wine intake	0.6	0.7	2.0	0.6	0.8	-0.3	-0.2	1.4	-1.1	1.1	0.6	1.0	-0.7
Maternal smoking around birth	0.1	0.2	0.8	0.0	0.6	-0.1	0.4	-0.9	0.3	0.2	-0.6	0.2	0.2
Fed-up feelings	0.3	0.6	1.8	-0.0	0.6	-1.0	0.5	-1.4	0.9	-0.5	-0.5	-1.0	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.5	-1.4	0.0	-1.2	-1.8	-1.1	0.6	-1.3	-1.4	-1.9	0.5
Relative age voice broke	0.2	0.4	1.7	-0.7	-0.1	0.7	0.1	0.5	0.7	-0.2	-0.1	-1.3	0.5
Taking other prescription medications	1.1	1.6	4.3	0.7	1.4	-0.9	0.5	-2.1	1.9	0.7	-0.4	-1.4	1.6
Age when periods started (menarche)	0.7	1.6	4.4	0.4	-0.4	1.3	0.1	1.1	-1.9	0.6	2.1	-0.0	-2.1
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	5.2	0.8	1.0	-0.2	1.0	1.3	-2.3	1.0	0.5	1.0	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	11.7	1.8	-0.3	-1.8	0.3	-2.3	1.6	-3.4	-2.9	-0.4	1.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.1	0.7	-0.4	-1.2	0.5	-1.3	0.8	-1.3	-1.8	-0.3	1.1
Qualifications: CSEs or equivalent	3.3	4.3	9.4	2.2	0.1	-0.5	3.1	2.6	-2.3	1.5	1.7	2.5	-2.5
Serious illness, injury or assault to yourself	0.5	0.6	1.6	-0.9	-0.4	-1.3	-0.4	-0.6	0.6	0.7	-0.2	-1.1	0.4
High blood pressure	0.2	0.7	2.2	-1.4	-1.5	0.7	-0.3	-0.7	0.2	-0.8	-0.2	-1.0	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.4	-0.2	1.2	-0.7	-0.0	0.3	0.2	0.8	1.1	0.1	0.2
Multivitamins +/- minerals	2.9	3.7	6.3	2.5	2.4	0.0	1.6	2.0	-1.5	2.5	2.4	1.3	-1.6
Stomach or abdominal pain in last month	1.7	2.1	6.9	-2.1	0.2	-0.4	-0.5	-0.9	2.5	0.2	-1.0	-0.9	2.6
Supplements: Glucosamine	1.3	1.7	5.3	0.5	0.9	-2.3	0.7	1.5	-0.9	1.3	1.7	1.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	-0.5	-0.1	0.5	-0.8	-1.2	0.4	-0.6	-0.1	-1.1	0.3
Medication: Atenolol	0.4	0.5	1.6	-0.5	-1.2	1.2	-0.8	-0.7	0.4	-0.7	0.0	-0.3	0.2
Medication: Levothyroxine sodium	1.0	1.8	5.2	-1.0	-0.2	-0.2	1.6	-1.4	1.7	-0.4	-1.1	-2.3	1.6
Sitting height	0.5	3.7	13.6	-3.6	1.6	3.7	-1.9	0.6	-1.4	-0.2	0.4	-1.1	-0.9
Chronic bronchitis/emphysema (father)	0.8	0.9	2.8	0.9	1.7	-0.5	-0.1	-0.9	1.0	0.4	-0.9	0.8	1.3
High blood pressure (mother)	0.4	0.5	1.9	-0.4	-1.3	0.2	0.9	-0.2	-0.0	-0.6	-1.4	0.1	-0.2
Body mass index (BMI)	0.2	0.8	1.8	0.6	1.1	0.5	-0.6	-0.4	1.2	0.8	-1.4	-0.4	1.3
Impedance of leg (left)	0.3	1.3	5.3	0.0	-1.0	0.6	-0.9	-1.0	1.5	-0.6	0.1	-2.3	1.3
Leg predicted mass (left)	0.1	0.5	1.1	-0.2	1.1	0.6	0.4	0.8	-0.9	0.3	-0.8	0.5	-0.6
Trunk fat mass	0.3	1.1	3.4	-0.0	1.0	1.8	-0.6	-0.4	1.2	0.2	-1.3	-1.3	1.2
Waist circumference	0.3	0.9	1.9	-0.1	0.7	1.0	-0.7	0.2	1.2	0.9	-1.2	-1.2	1.4
Number of incorrect matches in round	1.8	3.0	11.0	-3.3	-2.0	-0.7	-0.7	-1.7	0.5	-2.2	-1.1	-2.1	0.4
Past tobacco smoking	1.4	2.5	6.1	-2.2	-0.4	-0.5	-1.8	-0.4	2.5	1.1	-1.7	-0.8	2.4
Alcohol usually taken with meals	0.2	0.3	1.6	-0.4	-0.1	-1.3	-0.8	0.1	-0.1	-0.4	-0.3	0.3	0.1
Nervous feelings	1.8	3.4	8.3	-2.0	-1.3	-2.3	-0.2	-2.1	1.3	-2.4	-1.1	-2.9	1.1
Frequency of tenseness / restlessness in last 2 weeks	3.2	4.9	11.0	-2.9	0.2	-0.7	-1.7	-1.9	3.3	-0.5	-2.2	-2.7	3.2
Hearing difficulty/problems with background noise	1.8	2.8	8.2	-1.2	-2.2	-2.0	-1.5	-2.4	0.4	-2.9	-0.5	-0.8	-0.0
Hair/balding pattern: Pattern 2	0.8	1.1	2.8	0.3	-1.7	-1.4	1.3	0.3	-1.4	-0.5	0.3	1.0	-0.8
Had menopause	0.7	0.8	2.4	-1.6	-0.3	-1.0	-1.5	-0.6	0.7	0.4	-0.9	-0.3	0.7
Had other major operations	0.2	0.2	0.5	-0.3	-0.4	-0.7	-0.7	-0.7	-0.2	-0.5	-0.6	-0.2	-0.1
Forced vital capacity (FVC)	0.3	1.1	3.2	-1.0	-1.1	0.6	-0.4	-1.0	-1.1	-1.8	-1.1	-0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	9.0	2.3	0.0	-1.4	1.3	-1.3	1.1	-3.0	-1.9	-0.2	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.1	0.5	-0.0	0.8	-1.5	-0.5	-0.1	-0.4	-0.5	-0.9	-0.4
Qualifications: None of the above	0.3	0.6	2.2	-0.5	-0.2	-1.5	0.7	0.6	1.1	0.3	0.2	-0.6	1.2
Financial difficulties in last 2 years	0.2	0.2	0.8	0.6	0.3	0.1	0.4	0.3	-0.4	-0.2	0.1	0.9	-0.8
Mouth/teeth dental problems	1.0	1.6	4.3	0.6	-0.7	1.2	0.7	1.4	-1.9	-0.8	0.5	2.1	-1.6
Heart attack	0.3	0.4	1.2	0.6	-0.2	1.1	0.6	0.1	0.6	0.2	-1.0	-0.4	0.7
Allergy	0.3	0.7	2.0	0.1	-1.4	0.6	-0.7	-0.0	-1.2	-1.2	-0.5	0.3	-1.0
Pain all over the body in last month	0.3	0.3	0.8	-0.9	-0.2	-0.9	0.8	0.5	-0.4	0.6	0.4	-0.0	-0.4
Diabetes (self-reported)	0.1	0.1	0.5	-0.4	-0.1	0.5	0.1	0.2	0.1	0.7	-0.3	0.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.8	-0.4	1.2	-0.7	-0.2	0.7	-0.2	1.0	1.3	-1.1	-0.4
Medication: Ramipril	1.2	1.6	6.2	1.1	-0.3	-1.4	2.5	0.2	-1.2	-0.0	0.6	1.7	-1.2
Medication: Simvastatin	0.5	0.8	2.1	-0.7	0.1	0.4	1.4	-0.1	1.1	1.0	-1.0	-0.2	1.4
Fluid intelligence score	0.4	0.9	5.0	0.4	-0.1	2.2	-0.9	0.1	-1.1	-0.3	0.2	0.7	-1.1
Illnesses of siblings	1.4	2.0	5.3	0.6	-0.6	-1.0	1.1	1.6	-2.0	-0.4	1.6	1.5	-2.3
Neuroticism score	0.8	1.7	6.1	-1.6	0.1	-1.3	-1.0	-1.6	0.9	-1.5	-0.5	-2.5	0.4
Weight	0.1	0.6	1.8	0.0	1.3	1.1	-0.5	0.1	0.5	0.6	-1.0	-0.8	0.6
Impedance of arm (right)	0.2	1.1	3.0	0.1	0.5	1.7	1.3	1.3	-0.5	0.5	1.6	-0.8	-0.6
Arm fat percentage (right)	0.3	1.1	2.2	0.3	1.3	1.5	0.1	-0.0	1.4	1.0	-1.0	-0.9	1.5
Trunk fat-free mass	0.1	0.4	0.9	-0.5	0.9	-0.2	0.2	0.9	-0.9	0.4	-0.2	-0.1	-0.7
Hip circumference	0.1	0.4	1.7	0.5	1.3	1.1	-0.3	-0.1	0.1	0.5	-0.4	-0.4	-0.1
Time employed in main current job	0.6	0.7	3.1	0.4	-1.0	0.4	1.8	0.1	-0.5	-0.9	0.4	1.3	-0.4
Alcohol intake versus 10 years previously	0.5	0.7	2.4	-0.3	-1.4	0.9	-0.1	-0.3	-0.1	-1.1	-1.5	-0.9	0.0
Father’s age at death	0.3	0.5	1.8	-0.9	0.4	0.1	-1.2	-0.5	0.1	0.1	0.5	-1.3	0.0
Worrier / anxious feelings	2.0	3.7	8.6	-2.9	-0.8	-1.3	-0.9	-2.6	1.4	-2.0	-1.6	-2.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.4	-0.7	-0.3	-1.6	-0.6	-1.2	0.6	-0.8	-1.4	-0.7	0.3
Falls in the last year	2.3	3.1	7.8	-1.1	-0.7	-0.4	-0.9	-2.4	2.5	-1.4	-2.8	-1.2	2.2
Hair/balding pattern: Pattern 3	0.2	0.4	2.0	0.1	0.4	0.6	1.0	0.4	0.2	0.1	0.0	1.4	0.1
Number of live births	0.3	0.5	2.8	-0.2	-1.0	-1.7	-0.5	-0.6	0.2	0.1	0.4	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.1	-1.4	-2.0	-0.1	-0.0	-0.8	-0.7	-1.8	-1.9	-0.1	-0.6
Pulse rate	0.4	0.7	2.4	0.9	1.4	-1.5	0.6	0.3	0.2	0.8	0.5	0.6	0.5
Happiness	3.1	3.8	9.1	-2.0	-1.9	-1.0	-3.0	-2.7	0.7	-2.6	-1.9	-1.2	0.5
Noisy workplace	2.0	2.5	10.1	0.3	3.2	-1.2	0.7	1.2	1.3	2.5	-0.1	-0.9	1.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.5	-0.2	-0.8	1.6	-1.0	-1.0	0.2	-1.7	-1.9	0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.3	-0.3	0.6	0.0	1.1	0.2	0.4	0.8	-0.2	-0.2	0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	4.1	0.2	1.0	-1.4	1.7	0.3	-0.1	2.0	1.5	-0.2	-0.2
Asthma	0.2	0.3	0.6	0.8	0.2	0.6	0.8	0.2	0.4	0.7	0.5	-0.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	4.2	-0.9	1.4	-0.9	-1.4	-0.8	2.0	1.3	-0.2	-1.4	1.7
Medication: Cholesterol lowering	0.7	1.0	3.6	0.3	1.8	-0.1	0.7	-0.3	1.0	1.9	-0.2	-0.3	1.2
Depression (self-reported)	0.4	0.5	1.5	-0.4	1.2	-0.2	-0.0	-0.6	0.6	1.2	-0.2	-1.1	0.5
Medication: Lansoprazole	0.7	0.7	2.4	1.1	0.3	-0.9	0.4	-0.3	1.0	1.6	-0.4	0.1	1.2
Prospective memory result	0.4	0.5	3.0	-0.4	-0.8	-1.7	-0.4	0.2	-0.4	-0.5	-0.1	-0.5	-0.6
Lung cancer (father)	0.6	0.7	1.6	0.9	0.6	0.5	0.1	0.7	-1.2	0.7	1.0	0.3	-1.3
Illnesses of mother	0.8	1.0	2.4	0.5	-0.2	-0.5	-0.4	1.3	-1.2	1.0	1.6	1.1	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.4	-1.1	-0.9	0.9	0.1	-0.2	-1.0	-1.2	-1.2	0.3	-1.0
Pulse wave Arterial Stiffness index	1.1	1.2	6.5	-0.1	0.3	-2.6	-1.1	-0.9	-1.1	0.5	0.9	0.3	-1.2
Impedance of arm (left)	0.1	0.6	2.6	-0.2	0.1	1.6	1.1	0.7	-0.3	0.2	1.2	-0.6	-0.4
Arm fat mass (right)	0.2	1.0	2.3	0.3	1.5	1.5	-0.1	0.4	1.0	1.3	-0.9	-0.7	1.2
Trunk predicted mass	0.1	0.4	0.9	-0.5	0.9	-0.3	0.2	0.9	-1.0	0.5	-0.2	-0.1	-0.7
Standing height	0.1	1.2	2.5	-1.2	0.7	1.6	-0.0	1.1	-1.6	-0.3	0.6	-1.2	-1.4
Length of working week for main job	2.1	2.4	5.4	1.5	1.0	2.3	-0.1	1.9	-1.5	1.1	1.4	2.0	-1.5
Exposure to tobacco smoke at home	2.1	2.4	5.4	-1.3	-0.9	-0.2	-1.3	-2.3	1.9	-0.9	-2.0	-1.6	1.8
Breastfed as a baby	1.4	1.7	4.0	-1.9	1.2	2.0	-1.3	-0.4	1.5	0.8	-1.0	-0.7	1.6
Tense / ‘highly strung’	0.3	0.6	3.7	-1.0	-0.7	-0.1	-0.2	-0.3	-0.1	-0.2	0.3	-1.9	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.2	-2.0	-0.4	0.3	-1.3	-1.2	0.2	-0.5	0.2	-1.7	-0.1
Hair/balding pattern: Pattern 4	1.3	3.0	12.0	-3.5	-0.8	0.5	-1.5	-0.5	2.0	0.6	-1.1	-2.0	2.3
Birth weight of first child	0.4	0.7	2.6	-1.6	-0.2	0.6	-1.4	-0.7	-0.2	-0.6	0.8	-0.2	-0.2
Peak expiratory flow (PEF)	0.7	1.6	3.0	0.1	-1.7	-1.4	1.5	0.8	-1.7	-1.0	-0.3	1.4	-1.4
Pulse wave reflection index	0.8	1.0	3.5	-1.0	0.0	-1.1	-1.4	-1.9	0.8	-0.1	-0.9	-0.9	0.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	7.0	2.6	0.5	-0.8	-1.5	-1.3	-1.4	-0.9	-0.4	-0.1	-1.9
Loud music exposure frequency	1.7	1.8	4.8	-1.5	-2.1	-0.0	-1.2	-1.2	0.6	-2.2	-1.1	-1.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	5.7	-0.4	-1.1	2.4	0.3	0.6	-1.1	-0.9	-0.2	0.5	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	3.1	0.0	-0.0	0.4	-1.8	-0.8	0.9	-0.1	-0.8	-1.0	0.5
Blood clot in the leg (DVT)	0.2	0.2	0.8	-0.3	0.7	-0.4	-0.4	0.2	-0.5	0.9	-0.2	0.1	-0.4
Medication: Paracetamol	0.9	1.5	3.6	-1.0	0.3	-1.9	-1.9	-0.5	1.7	0.7	0.0	-0.8	1.4
Headache pain in last month	0.7	1.2	3.5	-1.2	0.3	-1.9	-0.5	-0.3	1.7	0.5	0.2	-1.0	1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	0.5	-0.8	-0.2	-0.6	0.9	-1.3	-1.1	0.2	1.1	-1.3
Glaucoma (self-reported)	0.6	0.7	1.4	-0.7	-1.2	-0.2	1.2	-0.2	-0.7	-1.2	0.5	1.0	-0.5
Gout (self-reported)	2.3	3.2	6.1	2.5	1.2	-1.4	2.1	1.6	-2.4	-0.2	1.7	1.6	-2.2
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	13.4	-1.0	-0.5	-0.3	-0.2	-2.8	2.8	-1.8	-2.9	-3.7	2.8
Medication: Amlodipine	0.9	1.3	3.8	1.0	0.5	-0.9	2.0	0.5	-1.3	0.4	0.7	1.8	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	1.0	0.1	0.8	-0.2	-0.5	-0.5	-0.7	0.7	-0.5	-0.8
Birth weight	0.2	0.5	2.8	-0.4	0.7	1.7	-0.3	-0.0	-0.5	0.7	0.5	-0.2	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.7	-0.8	0.1	1.3	-0.7	-0.2	0.5	0.0	-0.6	0.7	0.7
High blood pressure (siblings)	0.5	0.7	2.9	-0.8	-1.7	1.1	-0.1	-0.5	0.4	-0.5	-0.8	0.4	0.6
Forced vital capacity (FVC), Best measure	0.3	1.1	2.9	-0.9	-0.5	1.6	-0.3	-0.9	-1.1	-1.7	-1.0	-0.4	-1.3
Body fat percentage	0.4	1.6	4.0	0.4	0.8	1.6	-0.5	-0.7	2.0	0.5	-1.4	-1.4	2.0
Leg fat percentage (right)	0.5	1.8	5.1	1.1	1.0	0.4	-0.7	-0.9	2.2	1.0	-1.3	-1.4	2.3
Arm fat-free mass (right)	0.1	0.3	1.7	-0.5	0.5	-0.1	-0.9	-0.3	-0.1	-0.2	-1.3	-0.5	0.1
Exposure to tobacco smoke outside home	1.4	1.9	4.8	-1.5	1.0	2.2	-1.4	-0.4	1.9	0.6	-1.0	-0.5	1.9
Comparative body size at age 10	0.2	0.5	1.7	-0.0	0.9	0.7	0.6	1.3	0.2	1.1	0.5	0.1	0.3
Number of full brothers	0.5	0.7	4.0	1.1	-0.4	-2.0	0.2	-0.5	0.3	0.1	-0.9	-0.1	0.1
Worry too long after embarrassment	0.8	1.4	4.2	-0.3	0.8	-1.5	-1.4	-1.8	0.7	-2.0	-0.8	-0.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	8.5	-2.9	-1.1	-0.7	-2.5	-1.9	1.2	-1.0	-1.5	-2.1	1.2
Wheeze or whistling in the chest in last year	0.5	0.9	4.2	2.0	1.4	0.4	0.3	-0.2	0.1	1.3	0.6	-0.5	-0.1
Number of children fathered	2.1	2.3	6.1	-0.8	-1.8	0.2	-1.6	-1.5	0.6	-2.5	-2.3	-1.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.3	1.7	0.1	0.1	1.4	0.7	-1.8	-0.1	1.0	0.9	-1.6
Age at first live birth	0.4	0.7	3.4	-0.4	-0.7	1.1	-0.5	-0.5	-0.6	-1.8	-0.6	0.1	-0.7
Pulse wave peak to peak time	1.0	1.2	6.7	0.0	-0.4	2.6	1.0	0.8	1.0	-0.7	-1.0	-0.4	1.1
Health satisfaction	2.7	3.5	5.5	-2.1	-0.6	-1.4	-2.1	-2.3	2.4	-0.3	-1.9	-2.2	2.0
Shortness of breath walking on level ground	1.3	1.5	5.9	0.7	1.6	-0.1	0.7	1.4	-0.4	2.4	1.9	0.3	-0.3
Qualifications: College or University degree	1.0	3.2	6.9	-1.8	-0.7	-0.4	-2.6	-2.1	0.9	-2.5	-2.5	-1.6	0.8
Eye problems/disorders: None of the above	1.9	2.3	7.6	2.7	-0.2	-1.3	1.4	0.4	-2.0	-0.7	0.9	1.5	-1.9
Mouth/teeth dental problems: Loose teeth	0.4	0.4	3.3	-0.3	-0.3	-1.8	-0.1	-0.8	0.1	0.3	0.4	-0.2	-0.1
Emphysema/chronic bronchitis	0.7	0.8	3.9	1.0	1.0	-2.0	0.2	-0.9	0.7	-0.0	-0.3	0.0	0.8
Medication for pain relief, constipation, heartburn	0.9	1.6	5.2	0.4	-1.8	1.4	0.4	0.3	-1.7	-2.3	-0.3	0.8	-1.4
Neck or shoulder pain in last month	0.6	0.9	4.2	-0.1	2.0	-0.4	-0.3	-0.5	1.2	1.1	0.4	-0.3	1.2
Medication: Blood pressure	0.3	0.5	2.2	-0.7	-0.7	0.9	0.7	-0.4	0.4	-0.2	0.2	-1.5	0.4
Angina (self-reported)	0.7	0.9	2.0	1.4	0.6	0.9	0.9	1.0	-0.7	1.1	1.2	0.5	-0.5
Migraine (self-reported)	1.9	2.3	12.4	0.8	0.7	-3.5	2.2	0.8	-0.8	0.6	1.1	1.2	-0.8
Medication: Ibuprofen	2.1	2.5	6.6	-1.2	1.2	-0.6	-1.9	-1.3	2.6	1.0	-0.8	-1.8	2.1
Medication: Allopurinol	3.2	4.3	8.3	2.9	2.8	-0.9	2.1	1.7	-2.0	1.5	2.6	1.6	-1.7
Medication: Omeprazole	0.5	0.6	2.4	-0.3	-0.5	-0.6	1.6	0.7	-0.0	0.4	0.4	-1.6	0.1
Medication: Seretide 50 evohaler	0.3	0.3	1.9	0.3	0.3	-0.4	-0.5	-0.8	-0.1	-1.4	-0.5	-0.1	0.0
Mean time to correctly identify matches	1.2	2.4	7.0	-2.6	-0.8	-0.9	-0.9	-1.2	1.9	-0.3	-0.8	-1.9	2.3
Heart disease (mother)	0.2	0.3	1.0	-0.8	-0.4	-0.1	0.8	0.1	0.2	1.0	0.6	0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.7	1.1	1.1	-0.5	0.2	-0.5	1.2	0.0	-0.6	-0.1	1.6
Whole body fat mass	0.3	1.3	2.7	-0.0	0.9	1.4	-0.5	-0.6	1.6	0.4	-1.5	-1.2	1.7
Leg fat mass (right)	0.3	1.1	2.7	0.4	0.9	1.1	-0.4	-0.5	1.6	0.7	-1.3	-1.0	1.6
Arm predicted mass (right)	0.0	0.2	1.0	-0.6	0.4	0.0	-0.8	-0.1	-0.1	-0.0	-1.0	-0.4	0.1
Pulse rate, automated reading	1.3	4.2	9.7	-0.4	0.8	-0.5	-2.7	-2.5	2.8	-1.1	-2.2	-1.9	3.1
Alcohol intake frequency.	0.2	0.5	0.9	0.0	-1.0	-0.2	0.9	0.6	-1.0	0.6	0.4	0.8	-0.9
Comparative height size at age 10	0.4	2.2	7.3	0.4	-0.0	0.1	1.1	2.1	-2.7	0.2	1.3	0.7	-2.5
Number of full sisters	0.4	0.5	1.8	1.0	0.0	-0.8	1.3	-0.1	0.4	-0.3	-1.0	0.1	0.7
Suffer from ‘nerves’	1.4	2.3	10.5	-3.2	-0.6	-0.6	-0.5	-1.0	1.2	-0.4	-0.5	-2.6	1.2
Overall health rating	2.2	4.7	9.5	-1.2	-1.0	0.1	-2.6	-3.1	2.6	-1.6	-3.0	-2.5	2.0
Chest pain or discomfort	0.3	0.5	1.4	-0.3	-0.2	0.7	-0.2	-0.8	0.8	-0.6	-1.2	-0.8	0.7
Had major operations	0.4	0.4	1.6	0.9	0.7	0.8	0.7	-0.6	-0.1	-0.2	-0.1	1.3	-0.2
Age at last live birth	0.3	0.4	1.8	-0.0	-0.8	0.2	-0.4	-0.0	-0.7	-1.3	-0.3	0.5	-0.9
Family relationship satisfaction	1.3	1.6	4.2	-2.0	-1.6	-0.4	-1.9	-1.4	0.1	-1.3	-1.1	-0.6	-0.2
Leg pain on walking	1.6	2.0	3.9	0.4	1.8	-1.7	-1.0	-1.0	1.7	1.0	-1.3	-2.0	1.5
Qualifications: NVQ or HND or HNC or equivalent	5.1	6.1	14.1	3.0	2.8	1.1	1.6	3.0	-1.7	3.8	2.6	2.1	-1.8
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.6	0.3	0.1	-0.2	-1.9	-0.4	1.3	0.2	-1.3	-1.6	1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	0.6	0.4	0.4	1.0	1.2	-0.1	0.9	1.1	1.1	0.2
Medication: Aspirin	0.6	0.8	1.6	-1.1	0.2	0.2	0.5	-0.9	1.1	0.6	-1.3	-1.1	1.0
Supplements: Vitamin C	0.4	0.5	1.8	-0.4	0.2	0.7	0.9	0.7	-0.5	1.3	0.3	0.7	-0.5
Knee pain experienced in last month	0.7	1.1	3.8	0.4	2.0	-1.3	0.9	-0.6	1.2	0.9	-0.5	0.8	1.0
Hypertension (Self-reported)	0.2	0.6	2.6	-1.2	-1.6	0.2	-0.1	-0.8	0.2	-0.9	-0.3	-0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.4	-1.4	-1.1	-2.3	-1.0	-1.4	1.2	-0.2	-0.7	-2.5	1.1
Illnesses of father: Heart disease	1.6	2.2	4.6	-1.2	0.1	-1.1	-1.0	-1.9	2.0	-0.2	-1.6	-2.1	1.8
Illnesses of siblings: Diabetes	1.2	1.5	5.1	0.1	1.1	1.6	-0.8	-1.1	1.1	0.9	0.2	-2.2	1.3
Smoking status: Previous	1.6	2.4	5.6	1.7	0.5	1.1	1.8	0.9	-2.4	-0.5	1.9	1.1	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-0.8	0.1	1.2	0.5	1.0	-0.4	-0.2	-0.1	-0.2	-0.1
Whole body fat-free mass	0.1	0.3	0.9	-0.4	0.9	0.2	0.2	0.8	-0.8	0.4	-0.6	0.1	-0.5
Leg fat-free mass (right)	0.1	0.5	1.1	-0.4	0.8	0.9	0.2	0.7	-1.1	-0.0	-0.7	0.6	-0.8
Arm fat percentage (left)	0.2	0.9	2.3	0.2	1.1	1.2	0.0	-0.2	1.4	0.9	-1.0	-0.7	1.5
Average weekly red wine intake	0.6	0.9	2.2	-1.5	-1.1	0.5	-1.3	-0.9	0.5	-1.5	-0.6	0.1	0.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	-1.4	-0.6	-1.1	-0.6	-0.9	1.2	-0.4	-0.9	-0.9	1.4
Mood swings	0.7	1.2	3.0	-1.7	-0.9	-0.5	-0.4	-1.6	1.0	-1.4	-1.1	-1.0	0.6
Loneliness, isolation	0.6	0.9	2.5	0.5	-0.4	-1.6	-0.4	-0.2	-1.4	-1.0	0.6	0.0	-1.5
Long-standing illness, disability or infirmity	1.0	1.5	4.8	-0.9	-1.1	-0.8	-0.2	-1.4	1.6	-0.5	-2.2	-0.4	1.6
Ever had bowel cancer screening	0.8	0.9	3.7	-1.2	-1.0	0.5	-1.9	-0.9	0.8	-0.1	-0.7	-0.3	0.8
Diabetes diagnosed by doctor	0.2	0.4	1.9	-0.6	0.7	0.2	-0.0	-0.1	0.6	1.4	-0.6	0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.0	0.2	-1.7	-0.4	-0.9	0.4	-2.0	-0.1	0.5	1.3	-1.6
Friendships satisfaction	2.4	3.0	10.5	-1.6	-2.9	-0.4	-1.8	-1.1	-0.7	-3.2	-1.7	-0.4	-0.5
Qualifications: nursing, teaching	0.3	0.5	2.5	-0.1	0.4	1.1	-1.6	-0.5	0.2	0.4	0.2	0.5	0.3
Commuting to job workplace: Walk	0.4	0.4	1.1	0.1	-0.5	-0.6	0.8	0.3	-0.9	-0.8	-0.4	-0.3	-1.0
Eye problems/disorders: Cataract	1.7	2.0	5.6	-1.1	1.5	1.7	-0.9	0.1	2.2	1.0	-1.3	-0.1	2.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.4	-0.1	1.4	-1.0	0.1	0.0	1.5	1.9	0.1	0.4	1.6
Medication for cholesterol	0.4	0.7	1.6	-0.1	0.9	-1.1	-0.4	-0.6	1.2	-0.6	-0.4	-0.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	6.8	-0.3	2.6	0.3	0.1	-1.0	1.5	0.6	-1.3	-1.1	0.9
Back pain experienced in last month	1.1	1.6	3.9	0.9	0.5	-0.9	-1.3	-1.6	1.6	-0.2	-2.0	-1.0	1.3
Mineral and other dietary supplements	0.8	1.1	2.6	-1.6	-1.6	1.1	-0.6	-0.9	0.4	-1.3	-0.8	-0.8	0.6
Breast cancer (self-reported)	0.4	0.5	1.8	-0.5	-1.4	-0.2	-0.1	-0.5	-0.2	-1.2	-0.7	-0.8	-0.0
Asthma (self-reported)	0.1	0.2	0.7	0.9	0.0	0.4	0.4	0.1	0.1	0.5	0.5	-0.4	-0.3
Osteoporosis (self-reported)	0.4	0.5	2.2	-0.7	0.0	1.5	1.2	0.8	0.0	0.5	0.5	0.1	-0.0
Osteoarthritis (self-reported)	0.9	1.2	6.2	0.2	1.0	-2.5	1.1	-0.5	0.6	0.8	0.2	1.5	0.5
Medication: Aspirin	0.3	0.3	0.9	-0.6	0.0	0.2	0.4	-0.7	0.6	0.3	-0.9	-0.9	0.5
Medication: Gliclazide	0.9	1.1	3.1	-0.5	1.0	-1.8	-1.4	-1.6	0.3	-0.0	-0.9	-0.9	0.2
Illnesses of father: None of the above (group 1)	3.2	4.0	8.8	1.8	0.5	-0.6	1.6	2.1	-3.0	0.4	2.3	2.5	-3.0
Smoking status: Current	0.8	1.2	3.3	1.1	-0.6	-1.2	0.3	-1.8	-0.3	-1.8	-1.3	-0.9	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.6	-1.3	0.3	0.2	0.7	-0.8	0.1	-1.0	-1.6	-0.3	0.2
Whole body water mass	0.1	0.4	1.1	-0.4	1.1	0.2	0.3	1.0	-0.9	0.5	-0.4	0.2	-0.5
Leg predicted mass (right)	0.1	0.5	1.1	-0.4	0.8	0.9	0.3	0.8	-1.0	-0.0	-0.7	0.6	-0.7
Arm fat mass (left)	0.3	1.1	1.9	-0.1	1.2	1.4	-0.4	-0.2	1.3	0.9	-1.3	-0.9	1.4
Number of self-reported non-cancer illnesses	0.9	1.6	4.4	-0.7	-0.6	-1.0	0.7	-1.4	1.9	-0.3	-1.3	-1.4	2.1
Average weekly champagne plus white wine intake	0.4	0.5	1.0	-0.8	-1.0	-0.9	-0.8	-0.3	-0.7	-0.3	-0.4	0.9	-0.6
Miserableness	1.0	1.7	2.7	-1.2	-1.1	-0.1	-1.5	-1.3	1.6	-1.6	-1.6	-1.3	1.1
Guilty feelings	2.4	3.6	7.8	-2.4	-1.0	-1.3	-2.7	-1.7	1.8	-1.5	-1.1	-2.8	1.6
Wears glasses or contact lenses	0.7	0.8	3.2	-0.9	-1.6	-0.2	-0.0	-0.3	-0.6	-1.8	-0.2	-0.2	-0.7
Ever taken oral contraceptive pill	2.0	2.3	8.5	1.0	-1.8	-0.9	-0.8	-1.2	-1.7	-2.9	-0.7	0.2	-1.9
Hearing aid user	0.7	0.8	4.2	-1.4	0.1	-2.0	-0.4	0.2	0.7	0.2	0.3	-0.3	0.8
Mother’s age at death	2.0	2.5	4.5	-1.7	1.2	-0.9	-2.0	-2.1	1.8	-1.3	-1.6	-0.6	1.7
Financial situation satisfaction	0.5	0.6	1.7	0.7	-0.3	0.8	-1.3	-0.9	-0.7	-0.7	-0.3	0.2	-1.0
Tinnitus: Yes, now most or all of the time	1.4	1.6	5.9	-1.4	-0.0	-0.8	-1.1	-2.4	1.1	-1.4	-1.3	-0.3	1.1
Commuting to job workplace: Public transport	0.7	0.8	2.3	0.7	-0.2	0.5	1.0	0.0	-1.0	-1.5	0.9	0.9	-1.2
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.7	-0.2	-0.1	0.3	-0.4	-0.4	-0.5	0.5	0.4	-0.3
Medication: Blood pressure	0.5	0.9	2.6	-0.8	-1.6	1.0	0.1	0.8	-1.2	0.0	0.2	1.1	-1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.0	-0.8	0.4	0.7	-0.5	-0.2	1.7	1.5	-0.4	-0.6	1.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.5	1.6	2.1	-0.3	-0.6	0.1	0.3	1.0	-0.3	-0.5	-0.1
High cholesterol (Self-reported)	0.9	1.7	6.0	-0.7	1.4	-0.3	0.1	-1.1	2.1	1.1	-1.3	-0.2	2.5
Medication: Bendroflumethiazide	0.5	0.8	2.7	-1.2	-1.3	1.6	0.0	0.7	-0.5	-0.4	0.4	-0.6	-0.7
Medication: Paracetamol	0.9	1.3	3.5	-1.1	0.4	-1.9	-0.8	-0.2	1.7	1.2	0.3	-1.1	1.4
Medication: Lisinopril	0.2	0.2	0.9	-0.5	-0.8	0.6	-0.9	-0.1	-0.0	-0.3	0.2	-0.2	-0.0
Medication: Atorvastatin	1.0	1.3	4.0	0.0	1.9	1.8	-1.0	-0.4	0.2	2.0	0.7	-0.7	0.0
Illnesses of father: High blood pressure	0.8	1.0	3.3	0.2	-1.2	1.8	-0.9	-0.1	1.2	0.1	-1.1	-0.6	1.1
Alcohol drinker status: Never	0.7	0.8	3.0	-0.4	0.3	0.7	1.2	0.9	0.5	1.7	1.0	-0.3	0.9
Ever smoked	1.3	2.3	6.0	1.8	-0.2	-0.1	1.6	-0.3	-2.3	-1.9	1.3	0.8	-2.5
Basal metabolic rate	0.1	0.4	1.4	-0.1	1.2	0.6	0.1	0.8	-0.7	0.6	-0.6	0.0	-0.4
Leg fat percentage (left)	0.5	1.9	5.2	1.0	0.6	0.7	-1.1	-1.1	2.3	0.6	-1.3	-1.5	2.3
Arm fat-free mass (left)	0.1	0.3	1.2	-0.1	1.1	0.0	-0.4	0.3	-0.2	0.6	-0.8	-0.4	0.1
Number of operations (self-reported)	0.3	0.4	1.7	-0.2	-0.3	0.2	-0.8	-1.3	0.6	0.0	-0.6	0.5	0.6
Average weekly beer plus cider intake	1.0	1.5	6.0	2.5	1.5	0.7	0.4	0.5	-1.1	0.7	1.4	0.6	-1.4
Irritability	0.4	0.7	2.3	-1.1	-0.5	1.0	-0.0	0.9	-1.1	-0.0	0.5	-0.7	-1.5
Risk taking	0.7	1.0	3.9	1.3	1.0	2.0	-0.5	0.8	-0.4	1.4	0.4	0.7	-0.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.1	1.7	-0.2	1.0	0.9	1.5	-1.5	0.1	1.5	0.7	-1.8
Fractured/broken bones in last 5 years	0.8	1.1	3.3	-0.8	1.3	0.3	0.1	1.2	-0.4	1.6	1.8	0.6	-0.4
Age started oral contraceptive pill	0.6	0.8	2.3	-1.1	-0.2	0.5	-1.5	-0.5	0.8	0.0	-1.0	-1.1	0.8
Diastolic blood pressure, automated reading	1.4	4.3	12.3	-2.0	-3.5	-1.1	-1.8	-1.5	1.5	-2.7	-2.2	-1.8	1.4
Ever depressed for a whole week	0.4	0.4	1.9	0.3	-1.0	-0.1	-0.2	-0.1	-0.8	-1.4	-0.3	-0.0	-0.8
Unable to work because of sickness or disability	2.1	2.7	5.1	-1.0	1.5	-1.3	-1.7	-1.8	2.2	0.3	-1.8	-2.2	1.7
Commuting to job workplace: Cycle	1.0	1.2	3.1	1.5	0.1	-1.8	-0.2	-0.0	-1.6	-0.1	0.6	1.0	-1.6
Myopia	1.1	1.5	4.6	-0.2	-0.9	-1.8	-1.6	-1.1	0.4	-2.1	-1.7	-0.1	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.7	0.9	1.6	-1.1	-0.5	0.0	0.3	0.6	-0.3	0.4	0.4
Cholesterol lowering medication	0.6	0.9	2.2	0.2	0.4	1.5	1.3	0.6	-0.9	1.4	0.3	0.9	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.7	0.3	0.2	-1.3	1.6	0.0	0.7	0.3	-0.4	-1.6	0.7
Pain experienced in last month	1.1	1.8	5.0	0.6	-0.1	0.8	1.4	1.5	-2.2	0.1	1.2	1.3	-2.2
Supplements: Calcium	0.2	0.2	1.2	-1.1	-0.3	0.1	0.4	-0.7	0.1	-0.5	-0.4	0.1	0.0
Basal cell carcinoma (self-reported)	1.1	1.3	3.1	-1.8	-1.7	-1.3	-0.0	-1.0	1.3	-0.8	-0.9	-0.6	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.7	0.0	1.2	0.4	-0.0	0.7	0.3	-1.0	-0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.3	0.7	-0.1	-0.5	0.4	-0.7	0.9	-0.0	0.2	-0.5
Heart disease (siblings)	0.7	0.8	5.7	0.2	2.4	0.2	-0.7	-0.2	0.1	1.4	0.0	0.4	0.3
Alcohol drinker status: Previous	0.5	0.5	1.9	-0.7	0.7	-0.1	0.6	0.5	-0.1	1.2	1.4	-0.5	-0.4
Pack years of smoking	0.7	1.1	2.5	1.6	1.5	-0.4	1.0	0.6	-0.8	0.9	1.2	0.5	-1.2
Impedance of whole body	0.1	0.6	2.5	0.0	-0.4	1.3	0.1	-0.2	0.7	-0.3	0.6	-1.6	0.5
Leg fat mass (left)	0.3	1.2	3.0	0.4	0.7	1.2	-0.6	-0.7	1.7	0.5	-1.4	-1.1	1.7
Arm predicted mass (left)	0.1	0.3	0.9	-0.3	0.8	0.1	-0.6	0.3	-0.0	0.4	-0.9	-0.7	0.1