[Hub]/) : Traits : Heel T-Score : ← →

chr1:24,871,730-27,971,502

Best TWAS P=1.51e-18 · Best GWAS P=2.4e-21 conditioned to 6.47e-228

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RHCE	0.29	0.34	lasso	4	0.34	2.0e-42	5.5	-5.5	3.9e-08	-0.03	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM50A	0.32	0.37	lasso	8	0.37	6.9e-47	5.4	-5.5	4.3e-08	-0.03	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF593	0.25	0.21	lasso	4	0.25	9.0e-31	-2.8	-5.4	5.8e-08	0.07	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	ZNF593	0.25	0.10	lasso	3	0.13	3.9e-07	7.7	-7.9	3.8e-15	0.07	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	LDLRAP1	0.23	0.07	enet	34	0.04	3.0e-03	4.5	-5.2	2.0e-07	-0.02	0.37	0.42	TRUE
6	GTEx	Adipose Visceral Omentum	FAM110D	0.18	0.16	lasso	2	0.15	5.3e-08	7.0	7.1	1.6e-12	-0.08	0.01	0.99	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-96L14.7	0.25	0.10	lasso	4	0.11	2.0e-06	7.7	-7.9	2.9e-15	0.07	0.00	1.00	TRUE
8	GTEx	Adrenal Gland	ZNF593	0.40	0.10	enet	15	0.13	1.6e-05	7.0	-6.8	7.6e-12	0.08	0.00	1.00	FALSE
9	GTEx	Adrenal Gland	RP11-96L14.7	0.38	0.06	enet	15	0.14	1.5e-05	7.0	-7.1	1.6e-12	0.07	0.00	1.00	FALSE
10	GTEx	Artery Aorta	LDLRAP1	0.16	0.11	lasso	4	0.12	6.4e-07	-5.1	-5.3	1.5e-07	-0.01	0.19	0.78	FALSE
11	GTEx	Artery Aorta	TMEM57	0.14	0.15	enet	10	0.14	3.3e-08	5.5	-5.8	5.6e-09	-0.02	0.01	0.98	FALSE
12	GTEx	Artery Tibial	NUDC	0.13	0.00	enet	2	0.00	1.5e-01	-5.5	-5.3	1.1e-07	0.12	0.03	0.16	TRUE
13	GTEx	Artery Tibial	RP11-96L14.7	0.09	0.06	lasso	2	0.04	4.1e-04	7.0	-6.8	1.5e-11	0.08	0.01	0.99	FALSE
14	GTEx	Brain Caudate basal ganglia	CEP85	0.38	0.08	enet	26	0.28	1.1e-08	-2.3	-7.7	1.8e-14	0.12	0.09	0.07	FALSE
15	GTEx	Brain Caudate basal ganglia	RP11-96L14.7	0.59	0.34	lasso	9	0.34	1.8e-10	-2.8	-5.2	2.3e-07	0.07	0.42	0.54	FALSE
16	GTEx	Brain Hypothalamus	ZNF593	0.54	0.13	lasso	9	0.24	2.6e-06	-2.8	-6.3	2.6e-10	0.09	0.01	0.93	FALSE
17	GTEx	Brain Hypothalamus	RP11-96L14.7	0.56	0.14	lasso	9	0.30	7.6e-08	-2.8	-6.4	1.2e-10	0.09	0.01	0.96	FALSE
18	GTEx	Brain Putamen basal ganglia	LDLRAP1	0.34	0.18	lasso	4	0.17	6.3e-05	-5.1	-5.7	1.4e-08	-0.01	0.08	0.29	FALSE
19	GTEx	Breast Mammary Tissue	ZNF593	0.29	0.23	enet	16	0.26	2.0e-13	-2.8	-5.3	1.3e-07	0.07	0.86	0.14	FALSE
20	GTEx	Breast Mammary Tissue	RP11-96L14.7	0.26	0.21	enet	10	0.24	1.3e-12	-2.8	-5.3	1.3e-07	0.06	0.65	0.35	FALSE
21	GTEx	Breast Mammary Tissue	RP11-335G20.7	0.23	0.10	enet	5	0.09	2.4e-05	5.4	5.5	4.0e-08	0.03	0.02	0.98	FALSE
22	GTEx	Breast Mammary Tissue (Male)	MTFR1L	0.11	0.00	enet	18	-0.01	4.6e-01	-4.5	-6.1	9.0e-10	0.05	0.05	0.06	FALSE
23	GTEx	Cells Transformed fibroblasts	C1orf63	0.09	0.04	lasso	5	0.03	2.5e-03	4.9	5.2	2.1e-07	0.01	0.66	0.02	FALSE
24	GTEx	Cells Transformed fibroblasts	ZNF593	0.34	0.09	lasso	8	0.22	4.0e-16	-2.8	-7.2	5.1e-13	0.08	0.00	1.00	FALSE
25	GTEx	Cells Transformed fibroblasts	RP11-96L14.7	0.32	0.08	lasso	8	0.20	3.2e-15	7.7	-7.5	9.5e-14	0.08	0.00	1.00	FALSE
26	GTEx	Colon Sigmoid	ZNF593	0.18	0.14	lasso	4	0.16	3.6e-06	7.7	-7.6	3.2e-14	0.06	0.00	1.00	FALSE
27	GTEx	Colon Sigmoid	RP11-96L14.7	0.20	0.14	enet	7	0.15	7.7e-06	7.7	-7.3	3.6e-13	0.07	0.00	1.00	FALSE
28	GTEx	Colon Transverse	LDLRAP1	0.27	0.14	lasso	4	0.11	5.4e-06	5.5	-5.8	7.7e-09	-0.03	0.01	0.98	TRUE
29	GTEx	Esophagus Gastroesophageal Junction	LDLRAP1	0.27	0.03	lasso	5	0.02	5.1e-02	-5.1	-6.2	4.0e-10	-0.04	0.04	0.23	TRUE
30	GTEx	Esophagus Muscularis	LDLRAP1	0.11	0.01	enet	15	0.02	2.5e-02	-4.7	-6.4	1.6e-10	-0.01	0.07	0.41	TRUE
31	GTEx	Esophagus Muscularis	TMEM57	0.09	0.08	enet	14	0.07	5.2e-05	5.4	-5.1	3.1e-07	0.00	0.02	0.98	FALSE
32	GTEx	Heart Left Ventricle	ZNF593	0.28	0.19	lasso	4	0.21	1.2e-11	-2.8	-5.3	1.2e-07	0.06	0.13	0.87	FALSE
33	GTEx	Heart Left Ventricle	RP11-96L14.7	0.28	0.14	lasso	5	0.22	8.3e-12	-2.8	-5.5	4.6e-08	0.06	0.09	0.91	FALSE
34	GTEx	Lung	ZNF593	0.11	0.09	lasso	7	0.09	2.1e-07	7.7	-7.3	2.1e-13	0.07	0.00	1.00	FALSE
35	GTEx	Lung	TMEM50A	0.14	0.04	enet	15	0.00	1.3e-01	5.4	5.5	3.4e-08	0.06	0.02	0.94	FALSE
36	GTEx	Lung	FAM110D	0.20	0.12	lasso	1	0.10	5.1e-08	7.3	7.3	3.4e-13	-0.06	0.02	0.98	FALSE
37	GTEx	Muscle Skeletal	ZNF593	0.40	0.22	lasso	6	0.25	8.0e-25	-2.8	-5.5	3.6e-08	0.07	1.00	0.00	FALSE
38	GTEx	Muscle Skeletal	RP11-96L14.7	0.40	0.22	lasso	8	0.26	4.3e-25	-2.8	-5.5	3.1e-08	0.07	1.00	0.00	FALSE
39	GTEx	Nerve Tibial	ZNF593	0.17	0.06	lasso	4	0.12	9.0e-09	5.4	-5.5	4.1e-08	0.07	0.02	0.98	FALSE
40	GTEx	Nerve Tibial	FAM110D	0.17	0.09	lasso	3	0.09	6.0e-07	7.7	7.5	7.5e-14	-0.05	0.00	1.00	FALSE
41	GTEx	Nerve Tibial	RP11-96L14.7	0.22	0.07	lasso	5	0.15	1.1e-10	5.4	-5.2	1.6e-07	0.07	0.04	0.96	FALSE
42	GTEx	Skin Sun Exposed Lower leg	TMEM50A	0.13	0.14	enet	6	0.11	2.6e-09	5.4	5.3	1.1e-07	0.04	0.02	0.98	FALSE
43	GTEx	Spleen	TMEM50A	0.34	0.09	lasso	3	0.11	8.9e-04	5.4	5.3	1.1e-07	-0.01	0.02	0.60	FALSE
44	GTEx	Testis	NUDC	0.10	0.01	enet	16	0.06	1.4e-03	2.6	-8.8	1.5e-18	0.49	0.02	0.67	TRUE
45	GTEx	Testis	ZNF593	0.36	0.22	lasso	7	0.37	1.3e-17	4.4	-5.7	9.9e-09	0.05	0.05	0.95	FALSE
46	GTEx	Testis	ZDHHC18	0.23	0.11	lasso	2	0.13	2.4e-06	-5.4	-7.6	3.7e-14	0.46	0.90	0.02	FALSE
47	GTEx	Testis	TMEM57	0.25	0.11	enet	17	0.12	7.4e-06	5.4	-6.7	2.3e-11	-0.03	0.02	0.98	TRUE
48	GTEx	Testis	RP11-96L14.7	0.38	0.23	lasso	7	0.40	6.9e-19	4.4	-5.4	5.7e-08	0.05	0.10	0.90	FALSE
49	GTEx	Thyroid	LDLRAP1	0.35	0.24	enet	20	0.22	4.1e-17	-4.6	-5.3	1.1e-07	-0.01	0.48	0.51	TRUE
50	GTEx	Thyroid	TMEM50A	0.19	0.11	lasso	2	0.08	2.0e-06	5.4	5.4	6.6e-08	0.04	0.02	0.98	FALSE
51	GTEx	Whole Blood	ARID1A	0.07	0.00	enet	22	0.03	4.4e-04	-6.3	-5.9	3.0e-09	0.36	0.13	0.20	TRUE
52	GTEx	Whole Blood	TMEM50A	0.08	0.07	lasso	2	0.07	4.7e-07	5.4	5.3	1.3e-07	0.03	0.02	0.98	FALSE
53	METSIM	Adipose	LDLRAP1	0.09	0.07	enet	12	0.06	3.4e-09	-4.7	-5.2	1.7e-07	-0.01	0.46	0.53	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	RHCE	0.29	0.36	lasso	7	0.35	6.3e-47	5.4	-5.5	4.1e-08	-0.03	0.02	0.98	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	FAM110D	0.09	0.04	lasso	3	0.04	6.4e-06	7.7	7.5	8.5e-14	-0.05	0.00	1.00	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	TMEM57	0.04	0.04	lasso	2	0.04	8.5e-06	5.4	-5.4	7.0e-08	-0.03	0.02	0.98	FALSE
57	YFS	Blood	GPN2	0.05	0.02	enet	7	0.05	9.3e-16	-4.5	7.2	6.1e-13	-0.62	0.88	0.12	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RHCE	0.10	0.03	blup	18	0.03	1.1e-03	5.4	-5.4	8.0e-08	-0.02	0.02	0.94	FALSE
59	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM50A	0.07	0.02	blup	7	0.02	1.3e-02	5.4	-5.3	1.2e-07	0.00	0.00	0.59	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRRP1	0.03	0.02	enet	7	0.01	3.9e-04	6.0	5.3	9.2e-08	-0.01	0.02	0.95	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	LDLRAP1	0.03	0.01	blup	21	0.01	9.5e-03	4.9	-6.2	6.7e-10	0.01	0.01	0.55	TRUE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	RHCE	0.13	0.08	lasso	3	0.08	1.3e-16	5.4	-5.4	6.3e-08	-0.02	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM57	0.06	0.02	lasso	3	0.02	2.3e-05	5.4	-5.4	5.8e-08	-0.02	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RHCE	0.09	0.09	lasso	1	0.08	6.2e-05	5.2	-5.2	1.9e-07	-0.01	0.02	0.89	FALSE
65	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM50A	0.10	0.04	enet	3	0.04	6.1e-03	5.4	-5.5	4.5e-08	-0.03	0.00	0.78	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	RHCE	0.20	0.13	enet	8	0.10	3.7e-06	5.4	-5.5	4.1e-08	-0.03	0.01	0.98	FALSE
67	The Cancer Genome Atlas	Colon Adenocarcinoma	RHD	0.12	0.03	enet	4	0.02	3.1e-02	5.5	5.1	2.8e-07	0.02	0.00	0.55	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM57	0.06	0.03	enet	6	0.02	1.5e-02	5.2	-5.2	1.8e-07	-0.02	0.01	0.56	FALSE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	RHCE	0.13	0.02	blup	18	0.04	3.0e-02	5.4	-5.5	4.2e-08	-0.02	0.01	0.39	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	ZNF593	0.23	0.04	blup	52	0.06	6.7e-03	7.7	-6.3	2.4e-10	0.07	0.00	0.77	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RHCE	0.15	0.03	blup	18	0.03	1.3e-04	5.4	-5.4	5.9e-08	-0.03	0.02	0.96	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM50A	0.08	0.02	blup	7	0.02	1.5e-03	5.4	-5.3	1.1e-07	0.00	0.00	0.69	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GRRP1	0.08	0.08	lasso	2	0.08	6.6e-09	7.3	7.4	1.8e-13	-0.05	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RHCE	0.06	0.05	blup	18	0.05	1.4e-06	5.4	-5.5	4.3e-08	-0.04	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM50A	0.02	0.02	lasso	1	0.02	5.2e-03	5.4	-5.4	7.1e-08	-0.03	0.00	0.55	FALSE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RHCE	0.09	0.05	enet	3	0.04	2.4e-03	5.5	-5.5	3.1e-08	-0.04	0.01	0.87	FALSE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM57	0.16	0.04	enet	3	0.04	1.8e-03	5.5	-5.5	4.9e-08	-0.03	0.01	0.84	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC21	0.07	0.00	enet	7	0.03	2.4e-04	4.7	-6.7	2.0e-11	0.05	0.03	0.31	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	GRRP1	0.11	0.10	lasso	3	0.10	1.0e-11	7.3	7.0	2.0e-12	-0.05	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	RHCE	0.38	0.20	lasso	3	0.22	4.9e-24	5.4	-5.4	5.3e-08	-0.05	0.01	0.98	FALSE
81	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GRRP1	0.10	0.01	blup	52	0.04	6.9e-03	7.7	5.2	1.6e-07	-0.07	0.00	0.57	FALSE
82	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RHCE	0.21	0.15	blup	18	0.18	6.3e-09	5.4	-5.4	6.8e-08	-0.05	0.01	0.99	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	RHCE	0.16	0.07	blup	18	0.07	8.0e-09	5.4	-5.5	4.7e-08	-0.03	0.02	0.98	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM50A	0.11	0.03	lasso	2	0.03	1.9e-04	5.4	-5.4	5.9e-08	-0.02	0.00	0.93	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	ZDHHC18	0.04	0.01	enet	5	0.02	4.7e-03	-4.1	-6.6	3.1e-11	0.45	0.01	0.25	FALSE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RHCE	0.09	0.06	blup	18	0.06	1.3e-07	5.4	-5.5	5.2e-08	-0.04	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM50A	0.15	0.05	enet	2	0.05	5.0e-06	5.4	-5.2	2.6e-07	-0.01	0.00	1.00	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM57	0.02	0.00	blup	20	0.00	2.0e-01	5.1	-5.4	7.1e-08	-0.02	0.01	0.44	FALSE
89	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RHCE	0.18	0.14	lasso	2	0.15	3.6e-10	5.4	-5.5	4.8e-08	-0.03	0.01	0.98	FALSE
90	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM57	0.04	0.02	blup	20	0.01	3.9e-02	5.4	-5.4	7.0e-08	-0.02	0.01	0.64	FALSE
91	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RHCE	0.12	0.08	lasso	3	0.07	7.8e-04	5.4	-5.4	5.4e-08	-0.03	0.01	0.80	FALSE
92	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZNF593	0.27	0.11	blup	52	0.21	6.7e-09	7.3	-7.0	2.2e-12	0.08	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRRP1	0.08	0.05	blup	52	0.05	6.0e-06	7.3	6.4	2.0e-10	-0.08	0.00	1.00	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDC	0.08	0.01	blup	34	0.03	4.4e-04	-4.1	5.3	1.3e-07	0.03	0.00	0.04	TRUE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDIK1L	0.03	0.03	blup	37	0.02	7.0e-03	7.7	5.2	2.6e-07	0.02	0.00	0.92	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIGV	0.09	0.09	lasso	1	0.08	5.1e-09	-5.4	5.3	8.6e-08	-0.52	0.99	0.01	FALSE
97	The Cancer Genome Atlas	Rectum Adenocarcinoma	RHCE	0.23	0.04	blup	17	0.04	4.4e-02	5.4	-5.5	4.0e-08	-0.03	0.00	0.23	FALSE
98	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF593	0.10	0.02	lasso	4	0.04	1.9e-03	6.0	-5.7	1.2e-08	0.07	0.01	0.81	FALSE
99	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RHCE	0.29	0.03	blup	17	0.01	2.0e-01	5.4	-5.5	3.8e-08	-0.03	0.01	0.53	FALSE
100	The Cancer Genome Atlas	Stomach Adenocarcinoma	RHCE	0.06	0.05	blup	18	0.03	2.4e-03	5.4	-5.5	3.2e-08	-0.04	0.01	0.96	FALSE
101	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF593	0.10	0.04	blup	52	0.04	6.8e-04	-5.1	-5.3	1.2e-07	0.10	0.02	0.94	FALSE
102	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CNKSR1	0.11	0.05	enet	4	0.10	1.7e-04	7.7	6.8	7.8e-12	-0.06	0.00	0.95	FALSE
103	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RHCE	0.41	0.23	enet	8	0.22	3.1e-08	5.4	-5.5	4.1e-08	-0.03	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC21	0.07	0.00	blup	80	0.03	1.4e-03	4.2	-6.0	2.3e-09	0.04	0.09	0.14	TRUE
105	The Cancer Genome Atlas	Thyroid Carcinoma	GRRP1	0.08	0.04	lasso	4	0.05	2.3e-05	5.4	6.6	3.8e-11	-0.06	0.04	0.96	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	PIGV	0.04	0.04	lasso	4	0.04	2.1e-04	-5.2	5.2	2.6e-07	-0.52	0.14	0.10	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	RHCE	0.22	0.11	enet	6	0.12	5.1e-12	5.4	-5.5	3.8e-08	-0.04	0.02	0.98	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	ZDHHC18	0.34	0.42	enet	5	0.41	8.1e-43	-5.2	-5.6	2.3e-08	0.52	1.00	0.00	FALSE