TWAS hub - ALPL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0280	1.2e-03	0.031	0.014	0.016	0.012	0.015	0.00009	6.8e-03	0.00420	0.0110	5.7e-03
2	GTEx	Uterus	0.4180	0.1480	9.4e-03	-0.012	NA	0.001	NA	0.018	0.64000	NA	0.31000	NA	1.4e-01
3	YFS	Blood	0.0262	0.0128	1.3e-02	-0.001	0.005	0.000	0.005	0.000	0.96000	8.9e-03	0.36000	0.0051	5.3e-01
4	TCGA	Breast Invasive Carcinoma	0.0162	0.0078	4.6e-03	0.001	0.010	-0.001	NA	-0.001	0.21000	2.8e-03	0.82000	NA	6.3e-01
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0439	0.0204	1.4e-03	0.012	0.021	0.006	NA	0.004	0.01400	1.7e-03	0.05500	NA	1.0e-01
6	TCGA	Pancreatic Adenocarcinoma	0.2520	0.0740	2.6e-06	0.066	0.132	0.092	NA	0.096	0.00099	3.7e-06	0.00012	NA	8.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Mouth/teeth dental problems: Dentures	4.5	7.6	17.0	1.1	-1.0	-1.2	-4.1	-3.9	-3.2
Maternal smoking around birth	3.9	5.6	7.3	2.7	-2.4	-1.3	-2.7	-2.6	-2.3
Mean Putamen Volume	3.4	3.9	5.7	2.4	1.6	-0.9	-2.4	-2.0	-2.1
Mouth/teeth dental problems: Loose teeth	3.4	4.0	8.8	-1.3	0.1	-1.1	-2.5	-3.0	-2.5
Mouth/teeth dental problems	2.9	4.5	9.7	-0.4	0.2	1.5	3.1	2.4	3.0
Hand grip strength (right)	2.7	7.4	12.9	-1.4	-1.2	3.3	3.6	2.5	3.4
Bilateral oophorectomy (both ovaries removed)	2.7	3.2	9.7	-1.4	0.9	-3.1	-2.0	-1.3	-0.8
Neck or shoulder pain in last month	2.7	3.8	10.0	3.2	0.6	-0.6	-2.2	-0.2	-2.8
Length of working week for main job	2.5	2.7	9.5	1.1	0.1	3.1	2.0	1.3	0.4
Ever highly irritable/argumentative for 2 days	2.5	3.0	6.2	-1.5	0.3	-0.2	2.5	2.5	1.8
Worrier / anxious feelings	2.3	4.3	12.6	-0.9	1.9	-3.5	-2.3	-1.2	-1.4
Osteoporosis (self-reported)	2.3	2.9	7.2	-2.0	-0.4	-0.7	-1.9	-2.7	-1.4
Heel T-Score	2.2	17.5	57.6	5.7	-0.4	-0.4	3.8	7.6	0.6
Medication: Levothyroxine sodium	2.2	3.7	8.6	1.4	0.9	-2.9	-2.3	-1.9	-1.4
Number of incorrect matches in round	2.2	3.6	11.6	0.9	1.9	-3.4	-1.1	-1.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	6.9	-1.9	-2.1	1.5	2.6	2.6	1.9
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	8.0	-0.9	-0.4	1.5	2.8	1.5	2.6
Had major operations	2.1	2.5	5.1	-1.6	-0.4	-0.3	2.3	1.7	2.1
Commuting to job workplace: Car/motor vehicle	2.1	2.4	4.1	0.9	2.0	1.3	1.6	2.0	1.2
Chronotype (morning person)	2.0	4.6	13.0	2.3	1.4	3.6	1.7	2.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.6	-1.1	1.1	-1.2	-2.2	-1.8	-1.6
Medication: Allopurinol	1.9	2.5	4.1	1.2	-2.0	-0.6	-1.8	-1.3	-2.0
Suffer from ‘nerves’	1.9	2.9	6.7	-0.7	1.6	-2.6	-1.8	-1.7	-1.4
Relative age of first facial hair	1.8	3.8	15.9	1.8	4.0	-0.5	-0.9	0.0	-1.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	6.5	1.0	0.2	-2.5	-1.6	-1.4	-1.4
Average weekly red wine intake	1.8	2.7	4.3	-1.1	-1.2	2.1	1.8	1.6	1.8
Diabetes diagnosed by doctor	1.8	2.9	4.6	-1.4	-0.6	-2.1	-1.9	-1.7	-2.0
Worry (Nagel 2018)	1.7	3.6	12.0	-1.8	1.0	-3.5	-1.6	-1.1	-1.3
HDL Cholesterol	1.7	2.8	5.2	-0.4	-1.1	1.7	2.1	1.8	2.3
Relative age voice broke	1.7	2.6	11.4	-0.2	3.4	-1.5	-0.7	0.2	-1.2
Qualifications: A levels/AS levels or equivalent	1.7	3.8	7.4	-1.4	0.6	1.9	2.7	1.7	2.5
Comparative height size at age 10	1.7	9.2	49.8	-0.7	-7.1	2.0	-0.1	0.2	1.0
Long-standing illness, disability or infirmity	1.7	2.6	5.7	0.6	-0.7	-2.4	-1.9	-2.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.4	0.2	-1.7	-1.0	-1.8	-2.1	-0.7
Supplements: Calcium	1.7	1.9	5.4	0.1	-1.6	-0.4	-1.7	-2.3	-0.6
Lupus	1.6	2.4	5.2	-2.2	0.3	2.3	1.1	1.1	1.3
Hand grip strength (left)	1.6	4.3	6.9	-1.6	-0.4	2.5	2.6	1.8	2.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.2	1.0	0.2	-2.3	-1.2	-0.3	-1.9
Fluid intelligence score	1.6	3.3	6.6	0.2	2.0	2.6	2.2	1.2	1.8
Standing height	1.6	15.8	57.2	-2.9	-7.6	4.1	1.9	2.3	2.1
Peak expiratory flow (PEF)	1.6	3.6	8.1	-2.5	-2.8	1.3	0.6	0.1	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	8.8	-1.6	3.0	-0.5	0.2	0.3	1.0
Number of children fathered	1.6	1.8	6.6	1.1	1.4	-2.6	-0.0	0.6	-0.5
Medication: Omeprazole	1.6	1.9	4.5	0.3	-1.8	-1.2	-1.4	-2.1	-0.8
Asthma (self-reported)	1.6	3.2	6.4	-2.0	1.5	0.4	1.6	1.9	2.5
Sensitivity / hurt feelings	1.5	2.5	8.1	1.2	-0.9	-2.8	-1.6	-0.5	-1.4
Frequency of depressed mood in last 2 weeks	1.5	2.0	7.6	-1.0	2.8	-1.4	0.6	0.9	0.8
Taking other prescription medications	1.5	2.2	5.8	1.1	-0.9	-2.4	-1.5	-1.0	-1.6
Asthma	1.5	2.9	5.5	-2.1	1.1	0.0	1.5	1.9	2.3
Medication: Cholesterol lowering	1.5	2.4	6.2	0.1	-2.5	-1.2	-1.4	-1.6	-1.4
Gout (self-reported)	1.5	2.0	4.3	0.5	-2.1	-1.6	-1.3	-1.3	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.6	1.4	1.1	0.8	1.5	1.6	1.5
Risk taking	1.5	2.2	3.8	-1.7	2.0	1.7	1.2	1.4	-0.4
Neuroticism (Nagel 2018)	1.4	3.3	12.4	-0.4	0.8	-3.5	-1.9	-1.0	-1.3
Fasting Glucose	1.4	1.7	5.2	0.5	-0.7	-2.3	-0.7	-1.3	-1.5
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.1	-0.3	0.2	1.1	1.7	1.1	2.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.1	-1.3	0.1	-2.0	-1.1	-1.2	-0.9
Average weekly fortified wine intake	1.4	1.7	2.8	1.4	-0.4	-0.6	-1.5	-1.6	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.9	2.8	-1.9	-0.2	1.3	2.4	-0.7
Multivitamins +/- minerals	1.4	1.8	4.3	0.7	-1.7	0.4	1.1	2.1	1.3
Forced vital capacity (FVC)	1.4	5.6	21.7	-2.2	-4.7	0.7	1.3	1.1	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	9.2	2.3	-1.5	0.3	1.6	3.0	0.1
Loud music exposure frequency	1.4	1.5	3.6	-1.3	0.0	1.4	1.1	0.6	1.9
Comparative body size at age 10	1.4	3.7	7.1	1.8	2.1	-2.7	-1.7	-1.8	-1.3
Osteoarthritis (self-reported)	1.4	1.9	5.7	2.4	-0.3	-1.5	-1.4	-0.6	-0.8
Diastolic blood pressure, automated reading	1.4	4.4	10.2	-2.1	2.3	-0.2	2.0	1.3	3.2
Heart disease (siblings)	1.4	1.8	4.9	2.2	0.9	-1.5	-0.7	-1.0	-1.0
Hearing difficulty/problems: Yes	1.3	2.0	4.9	2.2	-1.2	-1.2	-1.7	-1.0	-0.5
Severe depression (siblings)	1.3	1.4	3.4	-0.9	0.7	-1.6	0.9	1.8	0.5
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.8	-0.1	-1.3	-2.4	-0.4	0.9	-0.0
Sitting height	1.3	9.3	44.0	-0.7	-6.6	2.9	1.2	0.7	0.9
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	12.1	-3.1	-3.5	0.2	0.5	0.5	1.8
Breast cancer (self-reported)	1.3	1.5	3.3	-1.3	0.7	1.8	-0.5	-1.4	1.2
Depressed Affect (Nagel 2018)	1.2	2.5	7.3	0.6	-0.2	-2.7	-1.8	-1.6	-1.1
Bipolar Disorder (2011)	1.2	1.2	4.6	0.9	0.2	0.3	1.1	2.2	0.6
Height	1.2	23.1	64.3	-3.9	-8.0	7.4	1.1	1.7	0.5
Medication for hormone replacement therapy	1.2	1.4	4.0	-0.0	-1.3	0.6	-1.4	-2.0	-0.4
High blood pressure (mother)	1.2	1.6	7.3	-1.3	2.7	-0.8	-0.2	-0.2	0.5
Qualifications: None of the above	1.2	2.6	6.1	0.9	-0.2	-2.0	-2.0	-0.9	-2.5
Pain all over the body in last month	1.2	1.3	2.8	-1.0	0.8	-1.4	-0.6	-1.7	-0.9
Medication: Simvastatin	1.2	1.7	4.3	-0.4	-0.9	-1.0	-1.8	-2.1	-0.8
Neuroticism score	1.2	2.6	13.3	-0.1	1.0	-3.6	-1.0	-0.6	-0.2
Tense / ‘highly strung’	1.2	2.0	4.9	-2.2	0.9	-1.6	-1.2	-1.5	-0.4
Commuting to job workplace: Public transport	1.2	1.4	3.3	-0.5	-0.5	0.8	1.8	1.7	1.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.4	1.6	-1.0	-1.2	0.9	1.9	0.5
Cholesterol lowering medication	1.2	1.8	3.0	-1.1	1.7	-1.0	-1.5	-1.7	-0.7
Alzheimer’s Disease (including proxy)	1.1	1.5	4.0	1.0	0.3	-1.5	-1.0	-1.0	-2.0
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.8	-1.0	1.7	2.2	2.0	0.8	1.6
Ovarian Cancer	1.1	1.5	6.7	-0.7	2.6	0.6	0.8	1.0	0.0
LDL Cholesterol	1.1	1.8	5.0	0.3	0.9	-1.2	-1.8	-0.3	-2.2
Number of treatments/medications taken	1.1	2.0	4.1	0.6	-2.0	-1.7	-1.4	-1.3	-0.8
Breastfed as a baby	1.1	1.4	3.1	-0.3	1.7	-0.6	-1.0	-1.0	-1.8
Medication for pain relief, constipation, heartburn	1.1	1.8	6.2	-1.1	2.5	1.7	0.7	-0.0	0.4
Medication: Seretide 50 evohaler	1.1	1.2	4.8	0.4	0.8	0.2	1.2	2.2	0.5
Medication: Gliclazide	1.1	1.3	3.6	-0.5	0.4	-1.9	-0.8	0.1	-1.7
Alzheimer’s Disease (in mother)	1.0	1.2	3.1	0.6	-0.0	-1.3	-1.1	-0.7	-1.8
Neuroticism	1.0	2.5	12.0	-0.0	1.0	-3.5	-1.0	-0.7	-0.5
Medication: Co-codamol	1.0	1.1	4.6	2.1	-0.1	-0.8	-0.9	-0.0	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	6.8	-0.4	1.0	-2.6	0.0	0.2	0.1
Serious illness, injury or assault to yourself	1.0	1.2	4.8	0.6	-2.2	-0.3	-0.8	-1.0	-0.2
Nervous feelings	1.0	1.9	7.9	-1.3	0.4	-2.8	-1.1	0.2	-0.6
Diabetes (self-reported)	1.0	1.5	2.5	-1.4	-0.2	-1.6	-1.3	-0.9	-1.4
Trunk fat-free mass	1.0	5.5	25.4	-1.0	-5.0	2.3	0.6	0.3	0.9
Trunk predicted mass	1.0	5.5	26.2	-0.9	-5.1	2.2	0.5	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.3	-0.3	1.8	1.1	1.2	1.2	1.4
Forced vital capacity (FVC), Best measure	1.0	3.7	13.1	-2.0	-3.6	1.2	0.8	0.9	1.5
Exposure to tobacco smoke outside home	1.0	1.4	4.4	2.1	-0.1	-1.3	1.1	0.8	-0.3
Emphysema/chronic bronchitis	1.0	1.1	3.7	1.9	-0.4	-1.2	-1.1	0.0	-0.4
Medication: Aspirin	1.0	1.3	3.1	-1.5	-1.4	-1.8	-0.2	-0.6	0.1
Smoking status: Previous	1.0	1.5	2.8	0.9	-1.5	-0.2	-1.1	-1.7	-1.4
Eye problems/disorders: Cataract	1.0	1.2	3.0	0.2	-0.9	1.0	1.3	0.6	1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.4	0.7	1.0	-0.9	-1.7	-0.8	-1.8
Guilty feelings	1.0	1.4	4.5	-0.6	1.8	-0.2	0.6	0.3	2.1
Wears glasses or contact lenses	1.0	1.1	3.6	0.5	0.5	-0.3	-0.8	-1.9	-1.4
Medication: Lisinopril	1.0	1.3	3.2	-0.2	-0.7	1.3	1.4	0.7	1.8
Ever smoked	1.0	1.7	3.7	-0.3	-0.9	-0.7	-1.8	-1.5	-1.9
Intelligence (Savage-Jansen 2018)	0.9	2.7	8.9	0.1	1.1	3.0	1.9	0.8	1.5
Type 2 Diabetes (T2D) (2018)	0.9	1.8	3.1	-1.2	0.1	-1.5	-1.8	-1.1	-1.6
Vitamin and mineral supplements	0.9	1.2	3.5	-0.2	1.9	-0.3	-0.9	-1.3	-1.1
Diabetes (father)	0.9	1.1	4.5	0.6	0.5	-0.7	-0.3	2.1	-0.9
Townsend deprivation index at recruitment	0.9	1.3	2.9	1.5	0.2	-1.7	-1.2	-0.7	-0.7
Had menopause	0.9	1.2	1.9	1.3	-1.4	0.7	-1.2	-1.3	0.0
Pulse rate	0.9	1.6	2.2	0.7	1.2	1.4	1.1	1.5	1.4
Exposure to tobacco smoke at home	0.9	1.0	2.2	1.1	0.2	-1.5	-0.8	-0.7	-1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.8	0.6	0.9	-2.6	-1.2	-0.5	-1.1
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.8	-0.7	1.5	0.3	1.0	1.7	0.7
Mean time to correctly identify matches	0.9	1.8	5.9	0.2	-0.0	-2.4	-1.8	-0.5	-1.1
Knee pain experienced in last month	0.9	1.5	3.6	0.9	0.6	-1.6	-1.2	-0.3	-1.9
Ever had bowel cancer screening	0.9	1.0	2.6	0.5	0.2	-0.8	-0.9	-1.6	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	5.3	-0.1	-0.8	-2.3	-0.3	-0.3	-0.7
Mineral and other dietary supplements	0.9	1.3	2.9	-1.7	1.4	0.7	-0.7	-0.8	-1.0
Medication: Aspirin	0.9	1.2	2.6	-1.5	-1.4	-1.6	0.1	-0.3	-0.1
Number of self-reported non-cancer illnesses	0.9	1.5	4.9	-1.2	0.6	-2.2	-1.2	-0.4	-0.9
Alcohol drinker status: Never	0.9	1.0	3.3	-0.6	0.6	-0.5	-1.8	-1.1	-0.8
Crohns Disease (2012)	0.8	1.2	2.9	-0.7	-1.3	0.2	1.4	1.7	0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.8	0.9	-1.3	-0.7	-1.2	-1.4	-0.2
Medication: Metformin	0.8	1.1	1.9	-0.2	-0.7	-1.0	-1.3	-1.2	-1.4
Supplements: Glucosamine	0.8	1.1	4.7	2.2	-0.8	-0.8	-0.1	0.6	-0.1
Time employed in main current job	0.8	0.9	2.2	-0.7	0.1	-0.4	1.0	1.5	1.2
Happiness	0.8	1.0	1.8	-0.6	1.3	-1.3	0.7	-1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	6.7	-2.6	-2.6	0.7	0.4	0.4	1.3
Birth weight of first child	0.8	1.4	5.3	-0.8	-0.9	2.3	0.9	0.4	0.9
High blood pressure (siblings)	0.8	1.2	2.6	-1.4	-0.7	1.2	1.0	-0.3	1.6
Arm fat-free mass (right)	0.8	4.0	17.1	-0.5	-4.1	1.8	1.2	0.5	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.1	0.3	-1.0	-1.4	-0.7	0.3	-1.5
Heart disease (mother)	0.8	0.9	2.8	-1.1	-0.9	0.3	-0.7	-1.7	0.3
Arm predicted mass (right)	0.8	3.9	16.0	-0.5	-4.0	2.2	1.0	0.3	1.0
Overall health rating	0.8	1.7	6.1	0.6	0.3	-2.5	-0.8	-0.8	-1.5
Family relationship satisfaction	0.8	1.0	3.5	1.0	0.4	-0.9	0.5	-1.9	0.3
Whole body fat-free mass	0.8	4.8	21.4	-1.2	-4.6	2.1	0.7	0.1	1.1
Friendships satisfaction	0.8	1.0	2.3	-1.2	-0.9	-1.5	0.5	-0.8	1.0
Whole body water mass	0.8	4.8	21.5	-1.1	-4.6	2.1	0.6	-0.0	1.0
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-0.6	1.4	1.5	1.1	0.1	0.9
Ever taken oral contraceptive pill	0.8	0.9	2.9	-1.7	-0.3	0.6	1.0	0.7	0.6
Mother’s age at death	0.8	1.0	3.2	1.8	0.6	-0.0	0.5	1.4	-0.6
Medication: Bendroflumethiazide	0.8	1.2	4.3	-2.1	-0.1	-1.4	0.8	0.4	0.4
Fractured/broken bones in last 5 years	0.8	1.1	2.6	-1.0	-1.6	-0.3	-1.1	-0.6	-1.1
Depression (Nagel 2018)	0.7	1.0	4.3	-1.1	0.2	-2.1	-0.2	0.2	0.8
Ulcerative Colitis (UC)	0.7	1.3	3.8	0.7	-2.0	-0.9	-0.7	-0.1	-1.4
HbA1C	0.7	0.8	2.6	0.7	0.9	0.4	0.7	0.3	1.6
Average weekly spirits intake	0.7	0.9	2.2	1.5	-1.1	-0.1	-0.3	-1.4	0.0
Systolic blood pressure, automated reading	0.7	2.1	4.9	-2.2	2.2	0.4	0.8	-0.1	1.4
Leg fat-free mass (left)	0.7	3.6	15.4	-1.3	-3.9	1.5	0.7	-0.0	1.3
Leg predicted mass (left)	0.7	3.6	14.7	-1.4	-3.8	1.6	0.8	-0.0	1.3
Past tobacco smoking	0.7	1.3	2.4	0.2	1.3	0.3	1.2	1.6	1.3
Medication: Ramipril	0.7	0.9	1.8	0.3	-1.1	-1.3	-1.3	-0.5	-0.7
Alcohol intake versus 10 years previously	0.7	1.1	5.6	-2.4	0.1	-0.3	-0.2	-0.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	4.8	-0.2	-0.2	-2.2	-1.0	-0.9	-0.6
Number of live births	0.7	1.0	3.8	1.1	0.2	0.2	-0.5	-0.7	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	1.7	-0.8	-0.5	0.2	1.1	-0.0
Glaucoma (self-reported)	0.7	0.8	1.8	-0.0	-1.1	0.4	-0.8	-1.4	-1.0
Medication: Amlodipine	0.7	1.0	1.9	-1.4	0.7	-0.5	-1.0	-1.2	-1.1
Worry too long after embarrassment	0.7	1.1	2.6	-0.2	-0.2	-1.4	1.2	1.6	0.8
Age at first live birth	0.7	1.2	2.9	-1.7	0.4	0.3	1.2	0.3	1.6
Pulse rate, automated reading	0.7	2.3	4.6	1.6	1.3	0.1	1.3	2.1	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	1.3	-1.2	-0.9	-0.7	-0.5	-0.0
Leg fat-free mass (right)	0.7	3.9	14.2	-1.5	-3.8	1.9	1.0	0.0	1.6
Mood swings	0.7	1.3	6.4	0.0	0.8	-2.5	-0.6	-0.2	-0.5
Qualifications: nursing, teaching	0.7	1.1	3.5	-0.2	1.3	1.9	0.7	-0.6	0.5
Leg predicted mass (right)	0.7	3.9	14.7	-1.6	-3.8	1.8	0.9	-0.1	1.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.5	0.2	-0.2	0.4	-1.0	-1.6	-1.2
Basal metabolic rate	0.7	3.8	16.2	-1.1	-4.0	1.9	0.9	0.3	1.1
Arm fat-free mass (left)	0.7	3.8	16.4	-0.2	-4.0	2.1	0.8	0.4	1.0
Average weekly beer plus cider intake	0.7	1.1	2.6	1.6	-1.2	-0.6	-0.2	0.1	-1.4
Irritability	0.7	1.2	3.4	-0.4	1.8	-1.7	-0.9	-0.2	-0.2
Pain experienced in last month	0.7	1.1	2.8	-0.6	-1.7	1.1	1.1	0.1	1.1
Arm predicted mass (left)	0.7	3.6	15.2	-0.2	-3.9	2.1	1.0	0.4	1.0
Schizophrenia vs Biploar Disorder	0.6	0.8	4.1	0.2	0.0	-2.0	0.4	-0.5	0.6
Age at First Birth	0.6	0.9	2.9	-1.7	0.4	1.4	0.5	0.0	0.5
Systolic Blood Pressure	0.6	3.0	11.4	-3.4	1.8	-1.7	-0.4	-0.7	-0.1
Stomach or abdominal pain in last month	0.6	0.8	2.9	-0.2	-0.3	0.0	-1.7	-1.0	-0.7
Hair/balding pattern: Pattern 2	0.6	0.7	3.0	-0.4	0.1	1.0	-0.6	-1.7	0.2
Medication: Lansoprazole	0.6	0.7	1.5	1.2	-0.7	-0.3	0.2	-0.8	1.2
Illnesses of mother	0.6	0.8	2.4	1.2	-1.5	0.7	-0.2	-0.4	-0.5
Qualifications: College or University degree	0.6	2.0	3.5	-1.3	-0.6	1.9	1.4	1.5	1.3
Medication: Blood pressure	0.6	1.0	1.5	-1.0	-0.8	-0.7	-1.1	-1.2	-1.2
Medication: Ibuprofen	0.6	0.7	2.0	1.1	-0.5	-0.5	0.5	1.4	0.2
Alcohol intake frequency.	0.6	1.4	4.2	-0.3	1.4	-2.0	-1.1	-0.6	-0.5
Number of full sisters	0.6	0.8	1.7	0.8	0.7	-1.3	-0.4	0.2	-1.3
Age at last live birth	0.6	0.8	2.3	-0.9	0.7	-0.2	1.1	0.0	1.5
Medication for cholesterol	0.6	0.9	2.6	1.2	-0.1	0.6	0.9	1.6	0.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.0	-0.4	-0.6	-0.3	-1.3	-1.4	-0.5
Number of operations (self-reported)	0.6	0.9	2.2	-0.8	-1.5	0.6	0.9	-0.3	1.2
Age started oral contraceptive pill	0.6	0.8	3.2	-0.3	-0.5	-1.8	0.2	-0.9	0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.4	1.6	-0.3	-0.8	-0.1	-0.2	-1.3
Schizophrenia (2018)	0.5	1.0	3.0	0.4	0.6	-1.7	-0.7	-1.2	-0.8
Irritable Bowel Disease (IBD)	0.5	1.2	5.7	0.3	-2.4	-0.2	-0.5	0.3	-0.9
Major Depression (MDD)	0.5	0.6	1.4	-0.1	0.6	-0.8	1.2	0.9	0.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	1.3	0.2	1.3	0.5	0.1	0.9
Triglycerides	0.5	0.8	3.1	-0.2	1.8	-0.8	-0.5	-0.2	-0.8
Ulcerative Colitis	0.5	0.8	3.5	-0.3	-1.9	0.1	0.8	0.7	-0.0
Blood Red Count	0.5	4.8	10.5	-2.6	3.2	-1.9	-1.2	-2.5	-0.5
Waist Hip Ratio (WHR)	0.5	2.5	6.5	0.4	2.1	-1.6	0.5	2.5	-1.0
Allergy or Eczema	0.5	1.4	5.2	-1.2	2.3	0.7	0.7	0.9	-0.1
Hypothyroidism (self reported)	0.5	1.2	5.8	0.9	0.4	-2.4	-0.6	-0.1	-0.5
Respiratory disease	0.5	1.1	2.7	-1.0	1.6	-0.1	0.4	0.9	1.5
Lung FEV1/FVC ratio	0.5	2.6	5.7	-1.9	1.9	-0.4	-2.4	-1.4	-0.7
Ever had hysterectomy (womb removed)	0.5	0.5	1.1	0.9	0.5	-0.7	-0.6	-0.5	1.0
Fed-up feelings	0.5	1.0	5.0	-0.1	-0.0	-2.2	-0.5	0.7	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.2	-1.8	1.8	0.3	0.5	-0.1	-0.2
Financial difficulties in last 2 years	0.5	0.6	1.5	0.1	-1.2	0.2	0.8	1.0	0.7
Heart attack	0.5	0.6	1.6	1.3	-0.3	-0.7	0.1	-0.3	-1.2
Falls in the last year	0.5	0.7	1.3	1.1	0.6	-0.0	1.0	1.0	0.6
Hair/balding pattern: Pattern 3	0.5	0.7	2.0	0.2	0.1	-0.9	1.1	1.4	0.6
Noisy workplace	0.5	0.6	1.9	0.2	-0.9	-0.4	-1.4	0.1	-0.7
Depression (self-reported)	0.5	0.5	2.4	-0.6	1.6	0.7	0.2	0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.0	-0.2	1.7	-0.1	0.6	0.6	0.9
Chest pain or discomfort	0.5	0.7	1.2	-1.1	0.5	-1.0	-1.1	-0.2	-0.8
Illnesses of siblings: Diabetes	0.5	0.6	0.9	-0.6	0.9	-0.9	0.8	0.9	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	-1.3	-0.2	0.2	0.6	0.7	0.8
Financial situation satisfaction	0.5	0.6	2.1	-0.3	-0.3	-1.5	0.9	0.1	0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.2	0.3	0.7	-0.5	0.3	1.5	0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.1	0.4	-1.4	-1.1	-0.5	-0.5	-0.1
High cholesterol (Self-reported)	0.5	0.9	1.8	-1.3	-0.3	-0.2	-1.3	-1.2	-0.7
Commuting to job workplace: Cycle	0.5	0.6	1.5	-0.9	-1.2	-0.7	-0.5	-0.7	-0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	-1.4	-0.2	0.8	0.6	-0.6	0.5
Bipolar Disorder (2018)	0.4	0.6	2.4	0.1	-0.1	1.0	-0.1	1.6	-0.6
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.9	-0.0	-0.1	-0.4	-0.7	-1.0
Prostate Cancer	0.4	0.6	1.3	-0.1	0.5	0.6	1.1	0.5	1.1
Coronary Artery Disease (CAD)	0.4	0.4	1.1	-0.6	0.2	0.1	1.1	0.5	0.8
Primary Biliary Cirrhosis	0.4	0.6	1.9	0.9	-0.4	-0.2	1.4	0.7	0.5
Smoking Status	0.4	0.9	2.2	-0.2	-1.0	0.3	-1.5	-1.2	-0.8
Lung FVC	0.4	1.9	7.2	-0.8	-1.1	-2.7	-0.2	-1.4	0.5
Supplements: Zinc	0.4	0.5	1.1	-0.6	0.3	0.8	-0.3	-0.6	1.1
Diabetes (mother)	0.4	0.5	1.2	1.1	-0.1	0.2	0.7	1.1	0.2
Age when periods started (menarche)	0.4	1.0	1.8	0.1	0.7	-1.1	-1.0	-1.2	-1.3
Medication: Atenolol	0.4	0.5	1.3	-0.6	0.0	-0.2	-0.1	-1.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	-0.8	0.9	-1.2	-0.6	-0.6	0.2
Had other major operations	0.4	0.5	1.4	-0.9	-1.2	0.5	-0.3	-0.4	0.5
Allergy	0.4	0.8	2.1	1.5	-1.2	-0.0	-0.5	-1.1	0.1
Father’s age at death	0.4	0.5	1.3	-0.5	-0.4	0.5	0.8	0.7	1.1
Prospective memory result	0.4	0.5	2.1	-0.3	0.1	0.5	-0.6	-1.5	-0.4
Pulse wave reflection index	0.4	0.5	1.5	0.0	-1.2	0.3	-0.5	-1.1	-0.5
Blood clot in the leg (DVT)	0.4	0.6	1.5	0.3	-0.5	-0.4	-1.2	-0.2	-1.2
Birth weight	0.4	0.9	1.7	-0.1	-0.8	0.2	1.3	1.2	1.2
Leg fat percentage (right)	0.4	1.5	3.7	1.5	1.6	-1.9	0.3	0.4	-0.4
Number of full brothers	0.4	0.5	0.8	0.1	0.9	-0.8	0.9	0.4	0.9
Shortness of breath walking on level ground	0.4	0.5	1.4	0.3	0.1	1.0	0.8	0.2	1.2
Migraine (self-reported)	0.4	0.5	1.0	-0.2	-1.0	0.9	-0.4	-0.8	0.5
Leg pain on walking	0.4	0.5	1.8	-0.1	0.4	-1.3	0.4	1.0	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.1	0.8	-0.0	1.1	0.6	0.2	0.7
Supplements: Vitamin C	0.4	0.5	1.3	-0.9	0.3	0.2	0.7	0.2	1.2
Commuting to job workplace: Walk	0.4	0.5	1.2	-1.1	0.4	0.1	-0.4	-0.8	0.8
Back pain experienced in last month	0.4	0.5	1.4	-0.4	0.7	-0.9	-0.1	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.4	-1.0	-0.2	-0.3	-1.5	-0.6	-0.8
Hearing aid user	0.4	0.4	2.1	0.2	0.1	0.1	-1.4	-0.2	-0.6
Medication: Atorvastatin	0.4	0.5	1.7	-0.4	0.1	-1.3	-0.0	-0.3	-1.0
Leg fat percentage (left)	0.4	1.6	4.1	1.4	2.0	-1.6	0.8	0.5	-0.2
Unable to work because of sickness or disability	0.4	0.5	1.0	-0.8	0.6	0.3	0.7	0.8	1.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.9	0.6	0.7	2.0	0.5	1.0	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.8	0.1	-0.4	0.1	-1.1	-0.3	-1.3
Alcohol drinker status: Previous	0.4	0.4	1.3	0.6	0.4	-1.2	-0.6	-0.6	-0.1
Pack years of smoking	0.4	0.6	1.3	1.0	-0.3	-0.9	-0.6	-0.2	-1.1
Crohns Disease (2017)	0.3	0.6	1.6	-0.2	-1.3	0.7	0.1	1.2	0.1
Reaction Time	0.3	0.5	2.0	-0.2	0.2	-1.4	-0.9	0.3	-0.1
Rheumatoid Arthritis	0.3	0.4	2.2	-1.5	0.3	-0.1	0.5	0.2	-0.3
Angina	0.3	0.4	1.3	0.3	-0.5	0.2	-0.7	-0.2	-1.1
Qualifications: CSEs or equivalent	0.3	0.5	1.7	-0.2	-0.1	-1.3	0.1	0.2	1.0
High blood pressure	0.3	0.8	2.3	-1.1	-0.5	-1.5	-0.2	-0.9	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	1.3	-0.3	0.1	0.1	0.8	1.1	0.3
Impedance of leg (left)	0.3	1.2	3.6	0.2	1.8	-0.3	0.7	1.9	-0.2
Alcohol usually taken with meals	0.3	0.5	1.3	-0.0	0.7	1.2	0.1	0.7	0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.2	-0.9	-0.7	-1.1	-0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.4	-0.1	-0.1	-1.2	0.5	0.2	0.3
Arm fat percentage (right)	0.3	1.4	3.4	0.6	1.6	-1.8	-0.6	-0.6	-1.1
Pulse wave Arterial Stiffness index	0.3	0.4	1.7	0.0	0.2	1.3	0.3	-0.5	0.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	-0.5	0.6	-1.1	0.5	0.4	1.1
Pulse wave peak to peak time	0.3	0.4	0.9	-0.5	-0.7	-1.0	-0.1	0.7	0.3
Health satisfaction	0.3	0.4	0.7	-0.7	0.2	-0.8	-0.7	-0.9	-0.0
Eye problems/disorders: None of the above	0.3	0.3	0.8	-0.7	-0.1	0.9	0.3	0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.7	0.0	-0.4	0.3	0.2	1.3	0.6
Hypertension (Self-reported)	0.3	0.7	2.5	-0.8	-0.2	-1.6	-0.4	-0.9	0.0
Illnesses of father: Heart disease	0.3	0.4	0.8	0.4	0.2	-0.9	-0.7	-0.4	-0.6
Arm fat percentage (left)	0.3	1.4	3.3	0.5	1.8	-1.8	-0.5	-0.6	-0.9
Smoking status: Current	0.3	0.5	2.1	-1.5	0.2	-0.5	-0.8	0.2	0.2
Medication: Blood pressure	0.3	0.5	1.3	-0.6	0.1	-0.8	0.3	-1.1	0.8
Illnesses of father: High blood pressure	0.3	0.4	1.0	1.0	1.0	-0.1	0.2	-0.5	-0.1
Ever depressed for a whole week	0.3	0.3	0.8	0.5	-0.8	-0.1	0.3	0.5	0.9
Myopia	0.3	0.4	0.9	-0.9	0.6	-0.4	-0.6	-0.2	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	0.4	0.4	-0.7	-0.6	0.0	-1.0
Breast Cancer	0.2	0.5	1.0	0.3	0.5	-0.8	-0.2	-1.0	-1.0
Neuroticism (2016)	0.2	0.3	0.9	0.1	0.1	-1.0	-0.1	-0.8	0.7
Schizophrenia (2014)	0.2	0.5	1.3	0.2	0.2	-1.2	-0.4	-0.6	-0.9
Pack years adult smoking proportion	0.2	0.3	0.7	0.6	-0.1	-0.6	-0.5	-0.2	-0.8
Impedance of leg (right)	0.2	1.0	3.6	0.5	1.2	-0.7	0.2	1.9	-0.5
Current tobacco smoking	0.2	0.4	1.3	-0.6	-0.3	-0.8	-1.2	0.0	-0.1
Body mass index (BMI)	0.2	0.8	1.5	1.0	1.1	-1.2	-0.1	-0.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.9	0.3	0.6	0.6	0.0	0.0
Illnesses of siblings	0.2	0.3	1.1	-0.1	-0.4	-0.1	-1.1	-0.3	-0.6
Weight	0.2	1.1	5.2	-0.3	-2.3	0.6	0.8	0.4	0.5
Lung cancer (father)	0.2	0.3	0.6	0.6	-0.0	0.8	-0.8	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	2.1	0.0	-1.1	-1.4	-0.4	0.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.2	0.3	-0.8	0.6	0.3	0.3
Medication: Paracetamol	0.2	0.4	1.1	1.0	-0.9	-0.3	-0.1	0.6	-0.2
Headache pain in last month	0.2	0.4	1.3	0.3	-0.6	-0.3	-0.6	-0.4	1.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.5	-0.2	0.6	0.8	0.1	0.2
Body fat percentage	0.2	0.6	2.2	0.5	1.1	-1.5	0.4	0.2	-0.4
Angina (self-reported)	0.2	0.2	0.8	0.3	-0.4	0.3	-0.5	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.8	0.0	-0.5	-0.3	-0.1	-0.4
Loneliness, isolation	0.2	0.3	1.2	-0.5	-0.1	-1.1	-0.5	0.1	-0.2
Miserableness	0.2	0.3	0.7	-0.5	0.5	-0.8	-0.0	-0.1	0.7
Medication: Paracetamol	0.2	0.3	0.9	0.9	-0.9	-0.4	-0.1	0.2	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.4	0.8	0.1	-0.3	0.2	0.3
Impedance of whole body	0.2	0.9	3.6	-0.9	0.9	-0.4	0.4	1.9	-0.0
Blood White Count	0.1	0.8	3.0	1.7	-0.5	-0.3	0.3	0.6	-1.0
BMI	0.1	0.7	4.0	2.0	0.2	-0.4	-0.1	-0.4	-0.3
Cardiovascular Disease	0.1	0.3	0.9	-0.0	-0.3	-0.9	-0.7	-0.2	-0.1
Trunk fat percentage	0.1	0.4	1.5	0.1	0.7	-1.2	0.4	0.3	-0.3
Trunk fat mass	0.1	0.2	0.7	-0.2	-0.8	-0.6	0.5	0.3	-0.1
Waist circumference	0.1	0.5	1.9	0.6	0.4	-1.4	-0.1	-0.2	-0.7
Impedance of arm (right)	0.1	0.6	1.9	-1.4	0.4	-0.7	-0.6	0.7	-0.5
Hip circumference	0.1	0.4	1.1	-0.1	-1.1	-0.2	-0.0	-1.0	0.4
Impedance of arm (left)	0.1	0.6	2.0	-1.4	0.5	-0.5	-0.3	1.1	-0.1
Leg fat mass (right)	0.1	0.2	0.6	0.7	-0.0	-0.8	0.2	-0.2	-0.3
Blood Eosinophil Count	0.0	0.3	1.1	-0.2	0.9	-1.0	0.1	0.0	-0.3
Blood Platelet Count	0.0	0.4	0.9	-0.8	0.8	-0.0	-0.1	0.9	-0.7
Hair Pigment	0.0	0.9	2.3	-0.4	0.3	-0.2	1.5	1.2	1.1
Tanning	0.0	0.3	1.0	-0.6	-0.2	-0.2	-1.0	-0.2	-0.3
Arm fat mass (right)	0.0	0.2	0.5	0.2	0.5	-0.7	-0.1	-0.2	-0.5
Whole body fat mass	0.0	0.2	0.6	0.2	-0.4	-0.8	0.2	-0.0	-0.4
Arm fat mass (left)	0.0	0.2	0.5	0.4	0.3	-0.7	-0.1	-0.2	-0.4
Leg fat mass (left)	0.0	0.2	0.3	0.6	0.1	-0.6	0.5	-0.1	-0.1

Hub : Genes

ALPL

Models

Trait associations