[Hub]/) : Traits : Heel T-Score : ← →

chr1:37,270,283-40,722,795

Best TWAS P=2.67e-32 · Best GWAS P=7.26e-29 conditioned to 0.613

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INPP5B	0.26	0.15	enet	30	0.26	8.4e-31	7.039	-9.3	2.0e-20	0.72	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SF3A3	0.05	0.03	lasso	3	0.05	2.8e-06	-11.077	9.9	3.8e-23	-0.87	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	MEAF6	0.17	0.07	lasso	6	0.12	7.4e-10	-3.835	-5.2	1.7e-07	-0.09	0.94	0.00	FALSE
4	GTEx	Adipose Subcutaneous	SF3A3	0.17	0.12	lasso	4	0.11	2.6e-09	-11.149	-11.1	1.2e-28	1.00	0.00	1.00	FALSE
5	GTEx	Adipose Subcutaneous	C1orf122	0.07	0.00	enet	16	0.03	1.6e-03	-6.108	6.4	1.9e-10	-0.47	0.14	0.28	FALSE
6	GTEx	Adipose Visceral Omentum	FHL3	0.10	0.02	enet	9	0.00	1.9e-01	-10.394	-11.3	9.1e-30	0.97	0.01	0.95	FALSE
7	GTEx	Adipose Visceral Omentum	SF3A3	0.20	0.18	lasso	2	0.18	1.5e-09	-11.077	-11.2	5.8e-29	0.99	0.00	1.00	FALSE
8	GTEx	Adipose Visceral Omentum	INPP5B	0.34	0.14	lasso	4	0.25	3.7e-13	8.017	-6.2	5.3e-10	0.36	1.00	0.00	FALSE
9	GTEx	Adipose Visceral Omentum	RP11-109P14.10	0.29	0.17	enet	18	0.16	7.7e-09	6.934	-6.3	2.1e-10	0.56	0.96	0.04	FALSE
10	GTEx	Adrenal Gland	FHL3	0.24	0.15	enet	17	0.34	7.4e-13	-11.149	-11.2	2.9e-29	0.82	0.00	1.00	FALSE
11	GTEx	Artery Aorta	RP11-69E11.4	0.13	0.10	enet	14	0.14	2.5e-08	4.504	5.6	1.8e-08	-0.05	0.42	0.56	FALSE
12	GTEx	Artery Aorta	FHL3	0.35	0.22	lasso	4	0.27	3.9e-15	-11.149	-11.8	3.8e-32	0.95	0.00	1.00	TRUE
13	GTEx	Artery Aorta	SF3A3	0.12	0.19	lasso	2	0.18	6.6e-10	-11.149	-11.2	6.3e-29	1.00	0.00	1.00	FALSE
14	GTEx	Artery Aorta	INPP5B	0.21	0.13	lasso	3	0.21	5.5e-12	7.295	-10.1	5.4e-24	0.79	0.11	0.89	FALSE
15	GTEx	Artery Aorta	RP11-109P14.10	0.26	0.17	lasso	3	0.16	3.9e-09	7.990	-9.3	1.2e-20	0.58	0.90	0.10	FALSE
16	GTEx	Artery Coronary	RP11-69E11.4	0.63	-0.01	lasso	9	0.10	2.2e-04	3.844	5.3	1.0e-07	-0.06	0.12	0.20	FALSE
17	GTEx	Artery Coronary	FHL3	0.31	0.22	lasso	5	0.18	1.3e-06	-11.149	-11.1	1.6e-28	0.94	0.00	1.00	FALSE
18	GTEx	Artery Coronary	SF3A3	0.19	0.02	lasso	3	0.00	4.1e-01	-11.149	-10.0	9.3e-24	0.95	0.01	0.96	FALSE
19	GTEx	Artery Coronary	UTP11L	0.16	0.04	lasso	4	0.05	9.8e-03	-7.581	-7.0	2.1e-12	0.67	0.07	0.76	FALSE
20	GTEx	Artery Coronary	INPP5B	0.27	0.28	enet	5	0.18	1.4e-06	-10.330	-10.3	8.0e-25	0.93	0.04	0.96	FALSE
21	GTEx	Artery Coronary	RP11-109P14.10	0.26	0.10	enet	10	0.00	3.7e-01	-11.149	-11.2	2.6e-29	0.98	0.01	0.99	FALSE
22	GTEx	Artery Tibial	FHL3	0.13	0.11	lasso	2	0.13	1.1e-10	-11.077	-11.5	1.8e-30	0.97	0.00	1.00	FALSE
23	GTEx	Artery Tibial	SF3A3	0.16	0.11	enet	8	0.12	1.2e-09	-11.149	-10.9	1.2e-27	0.95	0.00	1.00	FALSE
24	GTEx	Artery Tibial	UTP11L	0.09	0.14	lasso	3	0.12	1.1e-09	-11.077	-11.4	5.1e-30	0.97	0.00	1.00	FALSE
25	GTEx	Artery Tibial	C1orf122	0.07	0.00	lasso	6	0.00	4.0e-01	7.039	6.7	1.9e-11	-0.60	0.11	0.36	FALSE
26	GTEx	Artery Tibial	INPP5B	0.35	0.12	lasso	6	0.25	6.0e-20	-5.386	-8.9	5.1e-19	0.62	0.96	0.04	FALSE
27	GTEx	Artery Tibial	RP11-109P14.10	0.21	0.13	lasso	6	0.15	1.7e-11	7.990	-9.5	1.9e-21	0.64	1.00	0.00	FALSE
28	GTEx	Brain Hypothalamus	RP11-69E11.4	0.23	0.12	lasso	6	0.20	1.5e-05	4.317	5.6	1.9e-08	-0.02	0.13	0.56	FALSE
29	GTEx	Breast Mammary Tissue	FHL3	0.09	0.00	lasso	6	0.00	3.6e-01	-0.078	-5.1	3.1e-07	0.51	0.04	0.70	FALSE
30	GTEx	Breast Mammary Tissue	SF3A3	0.14	0.18	lasso	2	0.16	8.5e-09	-11.149	-11.2	5.2e-29	1.00	0.00	1.00	FALSE
31	GTEx	Breast Mammary Tissue	RP11-109P14.10	0.21	0.02	enet	18	0.05	9.9e-04	-1.457	-5.2	1.5e-07	0.22	0.11	0.05	FALSE
32	GTEx	Breast Mammary Tissue (Male)	SF3A3	0.07	0.16	lasso	1	0.03	5.7e-02	6.934	-6.9	4.1e-12	0.65	0.02	0.72	FALSE
33	GTEx	Breast Mammary Tissue (Female)	SF3A3	0.08	0.16	lasso	1	0.10	6.2e-04	-11.149	-11.1	7.3e-29	1.00	0.00	0.98	FALSE
34	GTEx	Cells EBV-transformed lymphocytes	SF3A3	0.23	0.11	enet	18	0.09	5.8e-04	-11.077	-9.9	4.6e-23	0.86	0.01	0.96	FALSE
35	GTEx	Cells EBV-transformed lymphocytes	INPP5B	0.31	0.32	lasso	2	0.30	1.6e-10	7.295	-7.3	2.9e-13	0.46	0.89	0.10	FALSE
36	GTEx	Cells EBV-transformed lymphocytes	RP11-109P14.10	0.24	0.20	lasso	4	0.17	3.2e-06	7.295	-7.3	3.7e-13	0.46	0.25	0.40	FALSE
37	GTEx	Cells Transformed fibroblasts	MEAF6	0.23	0.00	enet	37	0.13	2.9e-10	2.373	-5.4	6.8e-08	0.11	0.88	0.00	FALSE
38	GTEx	Cells Transformed fibroblasts	FHL3	0.24	0.17	lasso	4	0.15	1.4e-11	-11.077	-11.1	1.3e-28	0.97	0.00	1.00	FALSE
39	GTEx	Colon Sigmoid	INPP5B	0.43	0.15	lasso	6	0.31	1.2e-11	-5.386	-7.6	3.9e-14	0.45	0.51	0.47	FALSE
40	GTEx	Colon Sigmoid	RP11-109P14.10	0.31	0.27	lasso	5	0.25	2.4e-09	7.039	-8.8	9.8e-19	0.72	0.36	0.63	FALSE
41	GTEx	Esophagus Gastroesophageal Junction	SF3A3	0.23	0.11	lasso	6	0.08	7.7e-04	-11.077	-10.5	8.4e-26	0.95	0.01	0.98	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	INPP5B	0.34	0.12	enet	32	0.23	7.3e-09	10.794	-8.9	7.1e-19	0.67	0.15	0.83	FALSE
43	GTEx	Esophagus Mucosa	RP11-69E11.4	0.18	0.06	lasso	9	0.07	2.2e-05	4.629	5.1	2.7e-07	-0.05	0.40	0.58	FALSE
44	GTEx	Esophagus Mucosa	FHL3	0.14	0.14	lasso	5	0.12	3.4e-08	-11.077	-10.4	3.1e-25	0.94	0.00	1.00	FALSE
45	GTEx	Esophagus Mucosa	SF3A3	0.08	0.06	lasso	4	0.05	1.5e-04	-11.077	-11.1	1.5e-28	0.99	0.00	1.00	FALSE
46	GTEx	Esophagus Mucosa	PPIEL	0.11	0.02	lasso	3	0.02	9.4e-03	5.101	5.1	2.8e-07	-0.07	0.06	0.79	FALSE
47	GTEx	Esophagus Muscularis	FHL3	0.10	0.02	enet	2	0.00	4.3e-01	-10.602	-10.5	7.0e-26	0.85	0.04	0.66	FALSE
48	GTEx	Esophagus Muscularis	SF3A3	0.14	0.03	enet	13	0.06	2.9e-04	-11.077	-8.2	3.6e-16	0.79	0.00	0.99	FALSE
49	GTEx	Esophagus Muscularis	INPP5B	0.35	0.22	lasso	5	0.29	9.5e-18	-5.390	-8.1	4.2e-16	0.56	1.00	0.00	FALSE
50	GTEx	Esophagus Muscularis	RP11-109P14.10	0.17	0.11	lasso	6	0.13	3.6e-08	8.017	-10.3	1.0e-24	0.73	0.37	0.63	FALSE
51	GTEx	Heart Atrial Appendage	SF3A3	0.15	0.12	lasso	4	0.08	1.4e-04	-11.149	-11.0	2.3e-28	0.99	0.00	1.00	FALSE
52	GTEx	Lung	FHL3	0.14	0.07	enet	24	0.13	6.0e-10	-10.137	-11.1	1.0e-28	0.84	0.03	0.97	FALSE
53	GTEx	Lung	SF3A3	0.21	0.20	lasso	2	0.21	1.1e-15	-11.077	-11.2	5.9e-29	0.99	0.00	1.00	FALSE
54	GTEx	Lung	RP11-109P14.10	0.15	0.03	enet	14	0.12	9.2e-10	-5.386	-6.8	1.5e-11	0.51	0.91	0.02	FALSE
55	GTEx	Nerve Tibial	MEAF6	0.23	0.03	enet	24	0.15	1.4e-10	3.874	-5.8	7.4e-09	-0.01	0.91	0.00	TRUE
56	GTEx	Nerve Tibial	FHL3	0.20	0.12	lasso	7	0.14	1.9e-10	-10.330	-10.9	1.0e-27	0.92	0.03	0.97	FALSE
57	GTEx	Nerve Tibial	SF3A3	0.35	0.36	lasso	4	0.35	7.6e-26	-11.149	-11.2	4.2e-29	1.00	0.00	1.00	FALSE
58	GTEx	Nerve Tibial	UTP11L	0.11	0.00	enet	5	0.00	7.9e-01	-11.149	-10.5	8.8e-26	0.96	0.01	0.90	FALSE
59	GTEx	Nerve Tibial	INPP5B	0.24	0.17	lasso	6	0.20	3.5e-14	8.148	-8.1	4.2e-16	0.52	1.00	0.00	FALSE
60	GTEx	Nerve Tibial	RP11-109P14.10	0.21	0.15	lasso	4	0.16	4.1e-11	8.148	-8.3	7.2e-17	0.58	1.00	0.00	FALSE
61	GTEx	Ovary	RP11-69E11.4	0.25	0.05	enet	11	0.03	6.7e-02	4.610	5.3	1.3e-07	-0.07	0.05	0.36	FALSE
62	GTEx	Ovary	SF3A3	0.30	0.07	lasso	4	0.05	1.9e-02	-11.149	-10.2	2.4e-24	0.90	0.02	0.86	FALSE
63	GTEx	Pancreas	FHL3	0.17	0.05	lasso	3	0.10	6.6e-05	10.839	-11.8	2.7e-32	0.82	0.01	0.99	FALSE
64	GTEx	Skin Not Sun Exposed Suprapubic	FHL3	0.11	0.11	lasso	4	0.07	1.0e-04	-10.406	-10.3	4.5e-25	0.93	0.11	0.86	FALSE
65	GTEx	Skin Not Sun Exposed Suprapubic	SF3A3	0.24	0.14	lasso	4	0.15	1.1e-08	-11.149	-11.1	1.3e-28	0.99	0.00	1.00	FALSE
66	GTEx	Skin Sun Exposed Lower leg	RP11-69E11.4	0.13	0.12	lasso	6	0.15	1.3e-12	5.126	5.4	6.0e-08	-0.07	0.22	0.78	FALSE
67	GTEx	Skin Sun Exposed Lower leg	FHL3	0.15	0.09	lasso	5	0.10	1.2e-08	10.839	-10.9	7.3e-28	0.84	0.01	0.99	FALSE
68	GTEx	Skin Sun Exposed Lower leg	SF3A3	0.28	0.27	enet	29	0.28	3.2e-23	-11.149	-10.6	2.4e-26	0.95	0.00	1.00	FALSE
69	GTEx	Skin Sun Exposed Lower leg	MTF1	0.07	0.03	lasso	4	0.02	3.9e-03	8.148	5.6	1.8e-08	-0.43	0.18	0.07	FALSE
70	GTEx	Spleen	RP11-69E11.4	0.25	0.12	lasso	4	0.15	9.3e-05	4.629	5.4	8.2e-08	-0.06	0.13	0.72	FALSE
71	GTEx	Spleen	BMP8A	0.16	0.08	lasso	3	0.05	1.6e-02	5.126	6.0	1.7e-09	-0.07	0.06	0.35	FALSE
72	GTEx	Spleen	RP11-109P14.10	0.59	0.36	lasso	5	0.45	6.2e-13	7.039	-5.6	1.8e-08	0.42	0.90	0.02	FALSE
73	GTEx	Thyroid	SF3A3	0.13	0.16	lasso	2	0.16	1.7e-12	-11.149	-11.2	5.6e-29	0.99	0.00	1.00	FALSE
74	GTEx	Thyroid	INPP5B	0.14	0.06	lasso	4	0.09	1.0e-07	-1.457	-5.4	5.4e-08	0.30	0.95	0.00	FALSE
75	GTEx	Whole Blood	SF3A3	0.16	0.08	lasso	4	0.09	2.3e-08	-4.986	-8.7	2.8e-18	0.44	0.46	0.52	FALSE
76	GTEx	Whole Blood	INPP5B	0.18	0.10	enet	9	0.12	9.2e-11	6.934	-8.2	3.3e-16	0.62	1.00	0.00	FALSE
77	GTEx	Whole Blood	RP11-109P14.10	0.12	0.05	lasso	8	0.05	2.1e-05	7.039	-7.7	1.5e-14	0.64	0.95	0.04	FALSE
78	METSIM	Adipose	FHL3	0.15	0.12	lasso	5	0.14	6.3e-20	10.839	-11.3	1.3e-29	0.80	0.02	0.98	FALSE
79	METSIM	Adipose	MANEAL	0.03	0.03	blup	465	0.02	6.0e-04	-6.054	6.6	3.1e-11	-0.65	0.52	0.39	FALSE
80	METSIM	Adipose	SF3A3	0.08	0.11	lasso	3	0.11	7.4e-16	-11.077	-11.1	1.6e-28	0.98	0.00	1.00	FALSE
81	NTR	Blood	FHL3	0.12	0.08	bslmm	465	0.10	7.5e-31	-4.986	-7.2	5.1e-13	0.37	1.00	0.00	FALSE
82	NTR	Blood	INPP5B	0.05	0.03	lasso	4	0.04	3.6e-12	7.039	-8.6	1.3e-17	0.65	0.92	0.08	FALSE
83	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	-4.458	6.3	2.4e-10	-0.02	0.03	0.91	TRUE
84	NTR	Blood	SF3A3	0.10	0.12	lasso	6	0.13	7.2e-39	10.794	10.6	4.0e-26	-0.76	0.06	0.94	FALSE
85	ROSMAP	Brain Pre-frontal Cortex	EPHA10	0.10	0.06	enet	34	0.07	1.2e-09	10.794	-5.2	2.6e-07	0.42	0.06	0.94	FALSE
86	ROSMAP	Brain Pre-frontal Cortex	FHL3	0.07	0.06	enet	8	0.06	4.9e-08	-10.330	-10.3	5.2e-25	0.95	0.05	0.95	FALSE
87	YFS	Blood	FHL3	0.69	0.49	enet	33	0.57	8.2e-237	-4.986	-9.0	2.0e-19	0.43	1.00	0.00	FALSE
88	YFS	Blood	INPP5B	0.25	0.30	enet	18	0.31	6.1e-105	7.039	-8.5	2.0e-17	0.70	1.00	0.00	FALSE
89	YFS	Blood	SF3A3	0.50	0.29	enet	44	0.44	3.2e-162	-11.077	-10.7	1.5e-26	0.79	0.00	1.00	FALSE
90	YFS	Blood	UTP11L	0.09	0.05	lasso	6	0.07	8.6e-21	10.839	-8.4	6.5e-17	0.58	0.01	0.99	FALSE
91	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FHL3	0.08	0.02	enet	7	0.03	1.1e-03	-11.149	-10.0	2.3e-23	0.74	0.00	0.96	FALSE
92	The Cancer Genome Atlas	Breast Invasive Carcinoma	FHL3	0.06	0.01	enet	10	0.01	4.2e-04	10.839	-11.2	4.4e-29	0.72	0.02	0.96	FALSE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	FHL3	0.10	0.05	lasso	2	0.06	2.9e-04	-11.077	-11.7	7.5e-32	0.93	0.00	0.97	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FHL3	0.05	0.01	blup	45	0.03	3.4e-04	10.839	-7.7	1.9e-14	0.46	0.03	0.65	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	BMP8A	0.05	0.01	blup	48	0.04	6.8e-05	5.553	5.3	8.7e-08	-0.07	0.00	0.97	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	INPP5B	0.05	0.03	blup	68	0.05	6.7e-06	-10.137	-10.7	8.2e-27	0.86	0.04	0.95	FALSE
97	The Cancer Genome Atlas	Lung Adenocarcinoma	FHL3	0.03	0.02	blup	45	0.02	2.4e-03	-10.330	-10.3	8.1e-25	0.77	0.01	0.63	FALSE
98	The Cancer Genome Atlas	Lung Adenocarcinoma	INPP5B	0.04	0.02	lasso	5	0.02	2.6e-03	6.934	-8.0	1.1e-15	0.64	0.18	0.26	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	SF3A3	0.03	0.03	lasso	2	0.02	1.7e-03	-7.227	-7.3	2.6e-13	0.71	0.15	0.57	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FHL3	0.08	0.08	lasso	2	0.08	1.4e-09	10.839	-10.6	1.8e-26	0.72	0.04	0.96	FALSE
101	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FHL3	0.13	0.03	enet	6	0.05	4.9e-04	10.839	-10.1	3.8e-24	0.71	0.01	0.75	FALSE
102	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C1orf122	0.07	0.07	blup	32	0.05	3.8e-03	8.017	7.1	9.6e-13	-0.33	0.00	0.83	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	FHL3	0.09	0.03	enet	11	0.04	3.6e-05	-10.602	-8.8	1.5e-18	0.77	0.04	0.95	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	SF3A3	0.03	0.01	blup	55	0.01	1.9e-02	-7.356	-8.1	4.0e-16	0.65	0.07	0.35	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	UTP11L	0.05	0.00	blup	46	0.01	2.5e-02	1.177	-6.3	3.5e-10	0.59	0.01	0.29	FALSE
106	The Cancer Genome Atlas	Stomach Adenocarcinoma	FHL3	0.10	0.05	lasso	2	0.03	2.2e-03	10.839	-10.8	2.8e-27	0.72	0.01	0.82	FALSE
107	The Cancer Genome Atlas	Stomach Adenocarcinoma	YRDC	0.04	0.04	blup	37	0.03	2.1e-03	-6.120	7.5	6.7e-14	-0.69	0.03	0.35	FALSE
108	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SF3A3	0.15	0.03	blup	54	0.13	2.2e-05	-10.330	-9.2	5.9e-20	0.83	0.02	0.77	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	FHL3	0.12	0.03	enet	8	0.03	6.4e-04	-10.330	-10.8	4.2e-27	0.85	0.00	1.00	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	SF3A3	0.12	0.08	enet	13	0.11	1.7e-10	-11.149	-8.0	1.8e-15	0.80	0.00	1.00	FALSE