Hub : Genes

MANEAL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0580 0.025 0.0055 -0.002 0.010 0.00 NA -0.002 6.5e-01 0.0210 0.290 NA 0.95000
2 METSIM Adipose 0.0315 0.013 0.0022 0.031 0.019 0.01 NA 0.018 1.4e-05 0.0006 0.011 NA 0.00072

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.4 0.7 -0.8 -0.3
Bipolar Disorder or Schizophrenia 1.3 3.1 5.1 1.0 -2.3
Depressed Affect (Nagel 2018) 1.1 2.2 4.5 -0.0 -2.1
Depression (Nagel 2018) 3.6 5.3 10.3 0.6 -3.2
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.2 1.1 0.9
Neuroticism (Nagel 2018) 0.8 1.9 3.6 0.5 -1.9
Schizophrenia (2018) 2.7 5.6 7.2 2.0 -2.7
Schizophrenia vs Biploar Disorder 0.8 1.0 1.9 1.4 -0.4
Worry (Nagel 2018) 0.1 0.2 0.3 -0.6 -0.0
Alzheimer’s Disease (in mother) 1.0 1.1 2.0 0.4 -1.4
Alzheimer’s Disease (in father) 4.0 4.4 8.5 -0.5 2.9
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 -0.3 0.8
Crohns Disease (2017) 0.1 0.2 0.3 0.6 -0.2
Irritable Bowel Disease (IBD) 0.6 1.3 1.5 1.2 1.1
Ulcerative Colitis (UC) 1.2 2.3 2.8 1.4 1.7
Major Depression (MDD) 2.4 2.9 5.0 -0.9 -2.2
Reaction Time 0.0 0.1 0.2 0.1 -0.4
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.1 0.5
Breast Cancer 0.3 0.8 1.5 1.2 0.3
Ovarian Cancer 0.8 1.1 2.0 -0.5 1.4
Prostate Cancer 1.2 1.7 3.1 0.6 1.8
Age at First Birth 3.0 4.4 8.4 -0.6 2.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 -0.3 0.4
Coronary Artery Disease (CAD) 1.1 1.3 2.6 0.2 1.6
Crohns Disease (2012) 0.1 0.1 0.2 -0.5 0.1
Mean Putamen Volume 0.6 0.7 1.1 1.0 0.5
Fasting Glucose 0.3 0.4 0.7 -0.4 -0.8
HbA1C 0.4 0.4 0.5 0.7 -0.6
HDL Cholesterol 0.8 1.4 2.3 -0.7 1.5
LDL Cholesterol 0.2 0.4 0.6 0.4 -0.8
Lupus 1.3 2.0 3.5 -0.8 -1.9
Neuroticism (2016) 0.6 0.9 1.4 1.2 -0.7
Primary Biliary Cirrhosis 0.9 1.3 2.7 0.1 -1.6
Rheumatoid Arthritis 4.9 6.8 8.6 -2.9 -2.2
Schizophrenia (2014) 1.5 3.2 4.2 1.5 -2.1
Triglycerides 3.8 6.3 9.8 1.6 -3.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.1 -0.6 -1.0
Ulcerative Colitis 0.7 1.0 2.0 -0.1 1.4
Blood Eosinophil Count 2.4 18.8 34.8 -5.9 1.7
Blood Platelet Count 0.1 0.8 1.5 -1.2 0.0
Blood Red Count 0.5 4.9 8.6 -1.1 -2.9
Blood White Count 0.4 3.3 5.3 -1.1 2.3
Heel T-Score 2.8 22.2 44.1 -0.5 6.6
BMI 0.3 2.0 2.0 1.4 -1.4
Height 2.2 42.5 79.6 2.3 -8.9
Waist Hip Ratio (WHR) 0.2 0.7 1.5 -1.2 0.1
Systolic Blood Pressure 1.5 7.6 15.1 0.2 3.9
Smoking Status 0.0 0.1 0.1 -0.3 -0.2
Allergy or Eczema 2.3 6.0 8.4 -2.9 -1.9
Cardiovascular Disease 0.1 0.5 0.9 1.0 -0.1
Hypothyroidism (self reported) 3.0 6.9 10.2 -1.9 -3.2
Respiratory disease 0.4 0.8 0.9 -1.0 -0.8
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.7 0.2 -1.3
Lung FEV1/FVC ratio 1.1 5.7 8.7 -1.7 -3.0
Lung FVC 0.6 2.9 3.5 -1.5 -1.9
Neuroticism 0.1 0.2 0.4 0.2 -0.6
Chronotype (morning person) 3.0 6.9 13.5 -0.7 -3.7
Hair Pigment 0.1 1.6 3.0 0.6 -1.7
Tanning 0.0 0.2 0.2 -0.4 -0.5
Hand grip strength (left) 0.5 1.4 2.8 1.7 0.1
Number of treatments/medications taken 0.0 0.0 0.0 0.0 0.0
Average weekly spirits intake 1.2 1.5 1.6 1.2 -1.3
Sensitivity / hurt feelings 1.1 1.9 3.7 -0.2 -1.9
Frequency of depressed mood in last 2 weeks 3.7 5.1 10.0 0.5 -3.2
Hearing difficulty/problems: Yes 1.4 2.1 4.3 -0.0 -2.1
Relative age of first facial hair 1.4 2.9 4.0 1.4 2.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.0 -0.2 -1.0
Ever used hormone-replacement therapy (HRT) 0.5 0.7 0.9 0.7 -0.9
Ever had hysterectomy (womb removed) 1.8 2.1 2.5 1.3 -1.6
Systolic blood pressure, automated reading 1.8 5.2 9.4 -1.0 3.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.2 -0.2 -1.1
Angina 0.1 0.2 0.3 -0.1 0.6
Medication for hormone replacement therapy 1.0 1.1 1.5 1.2 -0.9
Vitamin and mineral supplements 0.2 0.2 0.3 0.6 0.4
Supplements: Zinc 2.4 2.6 4.5 2.1 0.9
Medication: Co-codamol 2.0 2.3 2.6 -1.4 -1.6
Medication: Metformin 0.7 1.1 2.1 -0.2 -1.4
Diabetes (father) 1.4 1.8 2.7 1.6 0.9
Diabetes (mother) 0.7 0.9 1.7 -0.1 -1.3
Severe depression (siblings) 1.5 1.6 2.9 -0.6 -1.7
Pack years adult smoking proportion 0.1 0.1 0.2 0.5 0.2
Impedance of leg (right) 0.5 2.5 4.8 0.6 2.2
Leg fat-free mass (left) 1.9 10.3 20.5 0.2 -4.5
Trunk fat percentage 0.8 3.3 6.6 0.2 -2.6
Hand grip strength (right) 0.1 0.4 0.4 0.6 -0.6
Townsend deprivation index at recruitment 0.7 1.0 2.0 0.3 -1.4
Current tobacco smoking 0.1 0.2 0.4 0.0 0.6
Average weekly fortified wine intake 0.2 0.2 0.3 -0.3 -0.6
Maternal smoking around birth 0.4 0.5 1.0 0.3 -1.0
Fed-up feelings 0.2 0.3 0.5 0.3 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 4.0 0.1 -2.0
Relative age voice broke 1.8 2.8 5.5 -0.3 2.3
Taking other prescription medications 0.2 0.4 0.6 0.4 -0.8
Age when periods started (menarche) 0.0 0.1 0.2 -0.2 0.4
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.2 1.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 4.2 0.2 2.0
Tinnitus: Yes, but not now, but have in the past 3.9 4.2 8.0 -2.8 0.7
Qualifications: CSEs or equivalent 1.6 2.1 2.6 -1.3 -1.6
Serious illness, injury or assault to yourself 0.4 0.5 0.7 -0.6 -0.9
High blood pressure 0.0 0.1 0.2 0.4 -0.0
Hayfever, allergic rhinitis or eczema 1.6 3.5 4.8 -2.2 -1.5
Multivitamins +/- minerals 0.1 0.2 0.3 -0.6 -0.2
Stomach or abdominal pain in last month 0.1 0.1 0.1 0.2 0.3
Supplements: Glucosamine 0.3 0.3 0.6 0.2 0.8
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.2 1.5 -0.1
Medication: Atenolol 0.6 0.7 1.5 0.0 1.2
Medication: Levothyroxine sodium 2.8 4.8 4.9 -2.2 -2.1
Sitting height 2.6 18.7 35.3 1.4 -5.9
Chronic bronchitis/emphysema (father) 0.8 1.0 1.2 1.1 -0.9
High blood pressure (mother) 0.5 0.7 1.0 -1.0 -0.7
Body mass index (BMI) 0.3 1.1 2.2 0.1 -1.5
Impedance of leg (left) 0.4 1.9 3.5 0.5 1.9
Leg predicted mass (left) 1.9 10.2 20.2 0.3 -4.5
Trunk fat mass 1.4 6.0 11.7 0.4 -3.4
Waist circumference 0.9 3.4 6.7 -0.3 -2.6
Number of incorrect matches in round 0.3 0.5 0.9 -0.1 -1.0
Past tobacco smoking 0.5 0.9 1.6 1.3 0.5
Alcohol usually taken with meals 0.0 0.0 0.1 -0.3 -0.1
Nervous feelings 1.2 2.3 2.3 1.5 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.5 -0.4 -1.2
Hearing difficulty/problems with background noise 1.8 2.9 4.7 -1.0 -2.2
Hair/balding pattern: Pattern 2 0.6 0.8 1.6 1.3 -0.0
Had menopause 1.2 1.5 2.9 0.4 1.7
Had other major operations 3.0 3.7 5.5 -1.4 -2.3
Forced vital capacity (FVC) 1.2 4.7 9.2 -0.5 -3.0
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 5.3 0.1 2.3
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 3.1 -1.8 -0.3
Qualifications: None of the above 0.2 0.4 0.6 0.5 -0.8
Financial difficulties in last 2 years 0.2 0.2 0.4 -0.2 -0.7
Mouth/teeth dental problems 0.1 0.2 0.4 -0.0 0.6
Heart attack 0.9 1.1 1.8 -0.6 1.3
Allergy 2.1 4.8 8.8 3.0 0.9
Pain all over the body in last month 0.3 0.3 0.4 0.5 -0.6
Diabetes (self-reported) 1.9 3.0 5.9 0.4 -2.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.9 -0.1 -0.9
Medication: Ramipril 0.0 0.0 0.1 -0.0 0.3
Medication: Simvastatin 0.1 0.1 0.2 0.0 0.4
Fluid intelligence score 0.2 0.4 0.7 0.3 0.8
Illnesses of siblings 0.2 0.3 0.6 0.8 0.1
Neuroticism score 0.0 0.0 0.1 -0.3 -0.1
Weight 1.8 9.1 17.8 0.6 -4.2
Impedance of arm (right) 0.1 0.3 0.6 0.1 -0.8
Arm fat percentage (right) 0.7 2.8 5.6 0.0 -2.4
Trunk fat-free mass 1.3 7.6 14.1 1.0 -3.8
Hip circumference 1.8 7.8 15.4 0.5 -3.9
Time employed in main current job 3.5 4.0 8.1 2.8 -0.1
Alcohol intake versus 10 years previously 1.5 2.2 3.4 -1.0 -1.8
Father’s age at death 1.3 1.8 3.5 -0.2 -1.9
Worrier / anxious feelings 0.3 0.5 0.5 -0.7 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.0 -0.1 -0.1
Falls in the last year 0.3 0.4 0.7 -0.8 -0.5
Hair/balding pattern: Pattern 3 1.0 1.4 1.7 -1.1 1.3
Number of live births 2.1 3.0 6.0 0.2 -2.4
Forced expiratory volume in 1-second (FEV1) 1.7 5.9 10.7 -1.0 -3.3
Pulse rate 0.1 0.2 0.2 -0.3 0.5
Happiness 0.5 0.6 1.1 -1.1 0.0
Noisy workplace 0.0 0.0 0.0 -0.1 -0.1
Qualifications: A levels/AS levels or equivalent 0.6 1.3 1.8 0.9 1.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.0 1.4 -0.6
Mouth/teeth dental problems: Dentures 1.8 3.0 5.7 -0.5 -2.4
Asthma 1.0 1.9 3.7 -1.9 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 2.9 1.7 -1.3
Medication: Cholesterol lowering 0.6 1.0 1.8 -0.4 1.4
Depression (self-reported) 3.7 4.4 8.3 0.7 -2.9
Medication: Lansoprazole 0.9 1.1 1.2 1.0 1.1
Prospective memory result 2.2 2.7 5.4 -0.1 -2.3
Lung cancer (father) 0.4 0.5 0.8 0.4 -0.9
Illnesses of mother 0.0 0.0 0.0 -0.1 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.7 13.9 -1.2 -3.7
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.3 -0.2
Impedance of arm (left) 0.0 0.2 0.3 -0.0 -0.6
Arm fat mass (right) 1.1 4.4 8.7 0.1 -3.0
Trunk predicted mass 1.3 7.4 13.6 1.1 -3.7
Standing height 1.9 18.8 36.0 1.2 -6.0
Length of working week for main job 0.1 0.1 0.3 -0.0 -0.5
Exposure to tobacco smoke at home 1.0 1.1 2.2 -1.5 -0.2
Breastfed as a baby 0.5 0.6 0.9 -0.6 0.9
Tense / ‘highly strung’ 0.1 0.1 0.3 0.1 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 4.1 -1.8 -2.0
Hair/balding pattern: Pattern 4 2.0 4.8 5.2 -2.3 2.1
Birth weight of first child 1.9 3.5 5.1 -1.4 2.3
Peak expiratory flow (PEF) 2.2 5.2 10.1 -0.5 -3.2
Pulse wave reflection index 0.1 0.1 0.2 0.2 -0.4
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.2 0.3 -0.5
Loud music exposure frequency 0.6 0.7 0.7 -0.8 -0.8
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 -0.2 -0.2
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.0 -0.5 1.4
Blood clot in the leg (DVT) 0.4 0.5 0.8 -0.5 0.9
Medication: Paracetamol 2.7 4.4 8.6 2.9 -0.4
Headache pain in last month 1.6 2.7 5.0 2.2 0.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 2.0 0.3 -1.4
Glaucoma (self-reported) 2.9 3.5 4.7 2.2 1.5
Gout (self-reported) 0.2 0.3 0.4 0.6 -0.4
Hypothyroidism/myxoedema (self-reported) 2.2 4.2 7.2 -1.1 -2.7
Medication: Amlodipine 2.4 3.3 6.5 -0.4 2.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.3 -0.4
Birth weight 0.1 0.3 0.5 0.2 -0.7
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.3 1.1 -0.8
High blood pressure (siblings) 0.1 0.2 0.4 -0.2 -0.6
Forced vital capacity (FVC), Best measure 2.2 8.2 15.8 -0.7 -4.0
Body fat percentage 0.6 2.3 4.4 0.3 -2.1
Leg fat percentage (right) 0.1 0.4 0.6 0.8 -0.5
Arm fat-free mass (right) 1.4 7.3 14.2 0.7 -3.8
Exposure to tobacco smoke outside home 1.3 1.8 3.4 -1.8 -0.4
Comparative body size at age 10 0.2 0.7 1.3 1.2 0.1
Number of full brothers 2.0 2.5 3.8 1.1 -1.9
Worry too long after embarrassment 0.5 0.9 1.7 1.3 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 4.2 -2.0 -1.4
Wheeze or whistling in the chest in last year 1.1 2.0 3.9 -2.0 0.3
Number of children fathered 0.4 0.5 0.9 0.1 1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 3.5 0.3 1.9
Age at first live birth 3.7 6.5 10.3 -1.6 3.2
Pulse wave peak to peak time 0.0 0.0 0.1 -0.2 -0.2
Health satisfaction 0.9 1.2 1.2 -1.0 -1.1
Shortness of breath walking on level ground 0.8 0.9 1.3 0.7 -1.1
Qualifications: College or University degree 0.9 2.9 4.9 0.9 2.2
Eye problems/disorders: None of the above 0.3 0.4 0.7 -0.2 0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.3 0.6 -0.3
Emphysema/chronic bronchitis 0.4 0.5 0.9 0.9 -0.2
Medication for pain relief, constipation, heartburn 0.4 0.6 1.2 -1.1 -0.1
Neck or shoulder pain in last month 0.4 0.5 1.0 0.1 -1.0
Medication: Blood pressure 0.6 1.1 2.1 -0.5 1.4
Angina (self-reported) 0.1 0.1 0.2 0.0 0.4
Migraine (self-reported) 2.8 3.5 6.8 -0.3 2.6
Medication: Ibuprofen 2.4 2.9 5.1 0.7 -2.3
Medication: Allopurinol 0.9 1.2 1.5 0.9 -1.2
Medication: Omeprazole 2.9 3.4 6.0 -2.4 -0.9
Medication: Seretide 50 evohaler 0.5 0.5 1.1 -0.0 -1.0
Mean time to correctly identify matches 0.1 0.2 0.2 -0.4 0.4
Heart disease (mother) 0.6 0.7 1.3 1.1 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.7 -0.1 1.3
Whole body fat mass 1.3 5.5 10.9 0.5 -3.3
Leg fat mass (right) 0.7 2.8 5.2 0.6 -2.3
Arm predicted mass (right) 1.2 6.0 11.3 0.8 -3.4
Pulse rate, automated reading 0.5 1.5 3.1 1.8 -0.0
Alcohol intake frequency. 1.3 3.0 3.3 1.8 -1.6
Comparative height size at age 10 1.0 5.3 10.3 0.6 -3.2
Number of full sisters 0.2 0.2 0.4 -0.6 0.0
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.4 -0.0
Overall health rating 0.6 1.2 1.3 -1.2 -1.1
Chest pain or discomfort 0.0 0.1 0.1 -0.3 0.2
Had major operations 0.5 0.6 1.0 1.0 -0.5
Age at last live birth 1.4 2.1 2.9 -1.7 1.1
Family relationship satisfaction 1.5 1.8 1.9 -1.3 -1.4
Leg pain on walking 0.8 1.0 1.7 -1.3 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.6 -1.6 -0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.0 0.2 -1.0
Illness, injury, bereavement, stress in last 2 years 3.2 3.9 7.0 -0.9 2.7
Medication: Aspirin 0.3 0.4 0.5 -0.6 0.7
Supplements: Vitamin C 0.6 0.7 1.3 0.2 1.2
Knee pain experienced in last month 0.6 0.9 1.2 -1.1 -0.8
Hypertension (Self-reported) 0.1 0.3 0.5 0.7 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 2.2 -0.7 1.5
Illnesses of father: Heart disease 2.2 3.1 4.3 -1.3 2.1
Illnesses of siblings: Diabetes 1.7 2.1 3.5 -0.8 -1.9
Smoking status: Previous 0.6 0.9 0.9 -0.9 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.8 5.9 8.9 1.7 -3.0
Whole body fat-free mass 1.6 9.3 18.1 0.7 -4.3
Leg fat-free mass (right) 2.1 11.1 22.2 -0.1 -4.7
Arm fat percentage (left) 0.6 2.3 4.5 0.2 -2.1
Average weekly red wine intake 0.5 0.8 0.8 0.9 -0.9
Handedness (chirality/laterality): Left-handed 1.5 1.7 2.6 1.0 1.6
Mood swings 0.2 0.3 0.4 0.4 -0.7
Loneliness, isolation 0.8 1.1 1.4 1.2 -0.9
Long-standing illness, disability or infirmity 2.7 4.1 5.7 -1.6 -2.4
Ever had bowel cancer screening 0.4 0.5 0.9 -0.9 -0.3
Diabetes diagnosed by doctor 0.9 1.4 2.9 0.2 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.6 -0.2 -1.6
Friendships satisfaction 0.8 1.0 1.5 -1.2 0.7
Qualifications: nursing, teaching 0.1 0.1 0.1 -0.2 0.4
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.0 0.3
Eye problems/disorders: Cataract 1.8 2.1 4.2 -0.3 -2.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 2.2 -1.5 0.6
Medication for cholesterol 0.1 0.1 0.1 -0.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 1.7 -1.3 0.9
Back pain experienced in last month 0.1 0.2 0.4 -0.1 -0.6
Mineral and other dietary supplements 0.2 0.3 0.4 -0.5 -0.6
Breast cancer (self-reported) 0.2 0.3 0.5 -0.0 0.7
Asthma (self-reported) 0.8 1.5 2.6 -1.6 -0.7
Osteoporosis (self-reported) 0.3 0.4 0.7 0.8 -0.2
Osteoarthritis (self-reported) 1.0 1.3 1.6 -1.0 -1.3
Medication: Aspirin 0.7 0.9 1.5 -0.5 1.2
Medication: Gliclazide 2.2 2.5 3.6 -1.9 1.2
Illnesses of father: None of the above (group 1) 0.5 0.6 0.7 -0.8 -0.8
Smoking status: Current 0.1 0.2 0.3 -0.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 4.0 -1.3 -2.0
Whole body water mass 1.6 8.9 17.3 0.7 -4.2
Leg predicted mass (right) 2.0 10.9 21.7 -0.0 -4.7
Arm fat mass (left) 1.0 4.1 8.1 0.3 -2.8
Number of self-reported non-cancer illnesses 0.4 0.8 1.5 -0.3 -1.2
Average weekly champagne plus white wine intake 1.2 1.6 3.2 -0.3 1.8
Miserableness 0.4 0.7 1.1 -0.5 -1.0
Guilty feelings 1.2 1.7 1.8 1.4 -1.3
Wears glasses or contact lenses 0.2 0.2 0.2 -0.5 0.5
Ever taken oral contraceptive pill 0.0 0.0 0.1 0.3 0.1
Hearing aid user 3.2 3.6 5.0 1.5 -2.2
Mother’s age at death 0.0 0.0 0.0 -0.1 -0.2
Financial situation satisfaction 2.0 2.4 4.8 0.4 -2.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.3 -0.5 -1.1
Commuting to job workplace: Public transport 1.7 2.0 4.0 -0.0 2.0
Eye problems/disorders: Glaucoma 2.0 2.4 3.1 1.8 1.3
Medication: Blood pressure 0.3 0.6 0.7 0.8 0.7
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.7 -0.3 1.3
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 0.5 -0.1
High cholesterol (Self-reported) 0.1 0.2 0.3 -0.5 0.3
Medication: Bendroflumethiazide 2.5 3.8 5.0 1.6 2.2
Medication: Paracetamol 2.0 3.1 5.1 2.2 -1.0
Medication: Lisinopril 0.1 0.2 0.3 0.6 -0.0
Medication: Atorvastatin 1.7 2.1 3.2 -1.0 1.8
Illnesses of father: High blood pressure 0.3 0.3 0.6 0.2 0.8
Alcohol drinker status: Never 1.2 1.4 1.7 1.1 1.3
Ever smoked 0.3 0.6 0.6 -0.7 -0.8
Basal metabolic rate 1.7 9.6 19.0 0.5 -4.4
Leg fat percentage (left) 0.1 0.5 0.5 0.7 -0.7
Arm fat-free mass (left) 1.4 6.9 13.3 0.7 -3.6
Number of operations (self-reported) 1.7 2.5 5.0 0.1 -2.2
Average weekly beer plus cider intake 1.1 1.5 1.6 -1.2 1.3
Irritability 0.4 0.7 1.3 1.1 0.3
Risk taking 0.2 0.3 0.5 -0.2 0.7
Ever had prostate specific antigen (PSA) test 1.0 1.1 1.9 0.6 -1.4
Fractured/broken bones in last 5 years 0.4 0.5 1.1 0.0 -1.0
Age started oral contraceptive pill 1.4 1.8 3.0 1.7 0.8
Diastolic blood pressure, automated reading 2.9 9.1 18.1 -0.3 -4.3
Ever depressed for a whole week 0.4 0.5 0.6 -0.8 0.6
Unable to work because of sickness or disability 0.7 0.9 1.0 -1.0 -0.9
Commuting to job workplace: Cycle 1.3 1.6 3.1 -1.8 -0.3
Myopia 0.3 0.4 0.6 -0.8 -0.4
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.1 -0.2 0.1
Cholesterol lowering medication 0.9 1.4 2.5 -1.6 0.5
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 4.0 -2.0 -0.6
Pain experienced in last month 0.0 0.0 0.0 -0.2 -0.2
Supplements: Calcium 1.0 1.1 2.1 1.4 0.2
Basal cell carcinoma (self-reported) 0.5 0.5 0.6 0.7 -0.8
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.3 -0.5 1.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.3 0.6
Heart disease (siblings) 0.2 0.2 0.3 0.4 0.6
Alcohol drinker status: Previous 2.0 2.3 4.5 -0.1 -2.1
Pack years of smoking 0.1 0.1 0.2 0.4 -0.0
Impedance of whole body 0.0 0.1 0.3 0.2 0.5
Leg fat mass (left) 0.8 3.2 6.1 0.5 -2.5
Arm predicted mass (left) 1.3 6.5 12.7 0.5 -3.6