Hub : Genes

YRDC

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0478	0.0127	2.5e-07	0.020	0.016	0.021	0.02	0.024	3.6e-07	4.6e-06	1.7e-07	3e-07	2.4e-08
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0461	0.0264	8.2e-04	0.011	0.019	0.003	NA	0.011	1.8e-02	2.6e-03	1.5e-01	NA	1.8e-02
3	TCGA	Stomach Adenocarcinoma	0.0410	0.0260	5.4e-03	0.042	0.032	0.018	NA	0.019	4.7e-04	2.1e-03	1.8e-02	NA	1.4e-02
4	TCGA	Testicular Germ Cell Tumors	0.0960	0.0650	9.1e-03	0.016	0.009	0.025	NA	0.004	8.5e-02	1.5e-01	4.3e-02	NA	2.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.6	0.8	0.3	-0.3	0.3
Bipolar Disorder or Schizophrenia	2.5	6.1	11.6	3.4	-0.0	-2.5	2.5
Depressed Affect (Nagel 2018)	1.7	3.6	6.2	1.9	-0.7	-2.5	2.0
Depression (Nagel 2018)	1.8	2.7	7.9	0.6	-1.2	-2.8	1.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	-0.6	0.9	0.6	-0.1
Neuroticism (Nagel 2018)	1.3	3.2	5.8	2.4	-0.6	-2.0	1.6
Schizophrenia (2018)	3.9	8.1	14.4	3.8	-0.3	-3.0	3.0
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	1.3	-0.5	-1.1	0.6
Worry (Nagel 2018)	0.3	0.7	2.0	1.4	0.1	-0.8	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	0.6	0.1	-0.9	1.2
Alzheimer’s Disease (in father)	3.1	3.3	8.9	0.7	2.0	3.0	0.1
Alzheimer’s Disease (including proxy)	1.4	2.0	2.6	1.1	1.6	1.6	1.4
Crohns Disease (2017)	0.1	0.1	0.4	0.6	0.2	-0.0	-0.2
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	0.3	-0.1	1.1	-0.7
Ulcerative Colitis (UC)	0.4	0.8	1.8	-0.3	-0.7	1.4	-0.9
Major Depression (MDD)	2.0	2.4	4.2	2.1	1.2	-0.9	1.8
Reaction Time	0.3	0.6	1.3	-1.2	-0.6	-0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-1.0	0.9	0.4	-0.0
Breast Cancer	0.3	0.6	1.3	-0.5	-1.1	-0.4	-0.8
Ovarian Cancer	1.1	1.5	2.2	-1.3	-0.5	1.4	-1.5
Prostate Cancer	1.4	1.9	2.9	-1.7	-0.1	1.5	-1.6
Age at First Birth	0.1	0.1	0.3	0.6	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-1.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.9	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.4	0.2	0.6	0.3	-0.1
Mean Putamen Volume	0.6	0.6	1.4	1.1	0.1	-0.2	1.2
Fasting Glucose	1.5	1.8	3.4	-1.9	-1.1	-0.4	-1.6
HbA1C	3.6	4.0	7.1	-1.2	-2.6	-0.9	-2.7
HDL Cholesterol	0.0	0.0	0.1	0.2	0.0	0.0	0.0
LDL Cholesterol	0.2	0.3	1.2	1.1	0.0	0.0	0.0
Lupus	2.3	3.5	5.9	-2.4	-1.3	-2.4	-0.9
Neuroticism (2016)	0.6	0.8	1.4	1.0	-0.6	-1.2	0.7
Primary Biliary Cirrhosis	1.1	1.5	3.2	-0.8	-1.3	-1.8	-0.6
Rheumatoid Arthritis	4.7	6.4	19.5	-4.4	-0.5	-1.1	-2.2
Schizophrenia (2014)	2.5	5.6	10.6	3.3	-0.2	-2.3	2.5
Triglycerides	0.6	0.9	3.7	1.9	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.2	0.0	0.0	0.0
Ulcerative Colitis	0.6	0.8	2.6	-0.3	0.6	1.6	-0.5
Blood Eosinophil Count	1.1	8.2	19.2	-4.4	2.0	3.1	-0.4
Blood Platelet Count	0.0	0.3	0.6	-0.8	0.2	0.6	0.5
Blood Red Count	0.5	5.1	11.8	1.6	3.4	0.7	2.3
Blood White Count	0.4	2.7	8.5	0.8	1.3	2.9	0.1
Heel T-Score	2.2	17.4	56.1	1.9	3.1	7.5	-0.0
BMI	0.1	0.6	2.1	0.3	-1.4	-0.3	0.5
Height	2.1	40.2	134.6	-1.9	-3.9	-11.6	2.8
Waist Hip Ratio (WHR)	0.1	0.3	0.6	0.4	0.5	-0.3	0.7
Systolic Blood Pressure	0.8	4.1	12.2	-0.6	-0.3	3.5	-1.9
Smoking Status	0.1	0.1	0.6	-0.0	-0.8	-0.1	-0.0
Allergy or Eczema	0.1	0.3	1.0	-1.0	0.3	-0.1	-0.2
Cardiovascular Disease	0.3	1.1	2.5	-0.2	-1.6	0.5	-1.3
Hypothyroidism (self reported)	4.3	9.8	19.0	-4.4	-2.5	-3.5	-1.2
Respiratory disease	2.8	6.2	13.7	-3.7	-2.5	-1.2	-1.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.9	1.4	0.6	-0.6	1.4
Lung FEV1/FVC ratio	3.2	16.0	26.6	5.2	3.0	-1.8	5.0
Lung FVC	0.5	2.6	6.2	0.4	2.0	-0.2	2.5
Neuroticism	0.7	1.7	3.6	1.9	-0.5	-1.2	1.2
Chronotype (morning person)	0.8	1.8	6.4	-0.5	-0.3	-2.5	0.6
Hair Pigment	0.0	0.9	2.9	-0.4	-0.8	-1.7	0.3
Tanning	0.0	0.4	1.0	0.7	1.0	-0.1	-0.3
Hand grip strength (left)	0.2	0.6	2.1	-0.1	-1.4	-0.5	-0.5
Number of treatments/medications taken	0.4	0.7	2.5	-0.1	-1.6	-0.2	0.5
Average weekly spirits intake	0.1	0.1	0.3	0.5	0.1	0.1	0.4
Sensitivity / hurt feelings	0.3	0.5	1.2	0.7	-0.4	-1.1	0.5
Frequency of depressed mood in last 2 weeks	1.7	2.4	7.5	0.2	-1.4	-2.7	0.4
Hearing difficulty/problems: Yes	1.6	2.4	5.5	1.3	0.8	-1.3	2.4
Relative age of first facial hair	0.3	0.7	1.7	-0.0	0.0	1.3	1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	0.6	-0.2	-1.1	1.1
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.2	2.3	1.2	-0.3	2.2
Ever had hysterectomy (womb removed)	0.7	0.8	2.6	-0.5	-0.6	-1.6	-0.3
Systolic blood pressure, automated reading	0.8	2.4	8.5	0.2	0.9	2.9	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	0.4	-0.2	-0.7	1.1
Angina	0.5	0.7	1.6	-0.3	-1.0	0.1	-1.3
Medication for hormone replacement therapy	0.3	0.3	1.0	-0.1	-0.4	-1.0	-0.2
Vitamin and mineral supplements	0.4	0.6	1.1	-0.9	-0.5	-0.3	-1.1
Supplements: Zinc	0.4	0.4	0.8	0.9	-0.6	0.4	-0.5
Medication: Co-codamol	0.4	0.4	0.7	-0.8	0.8	-0.1	0.7
Medication: Metformin	1.8	2.5	4.9	2.2	1.5	-1.0	1.4
Diabetes (father)	2.1	2.6	5.1	-1.2	-1.9	-0.4	-2.3
Diabetes (mother)	0.5	0.6	2.1	1.5	0.2	-0.5	0.3
Severe depression (siblings)	1.0	1.1	3.7	-0.3	-0.7	-1.9	-0.1
Pack years adult smoking proportion	0.1	0.2	0.6	0.5	0.4	-0.1	-0.7
Impedance of leg (right)	0.1	0.7	1.7	1.3	0.4	0.7	-0.5
Leg fat-free mass (left)	0.9	5.0	14.1	-1.2	-1.7	-3.8	1.2
Trunk fat percentage	0.2	0.9	2.3	0.1	-0.8	-1.5	0.8
Hand grip strength (right)	0.2	0.5	1.0	-0.5	-1.0	-0.6	-0.7
Townsend deprivation index at recruitment	3.6	5.0	6.2	-2.4	-2.5	-1.9	-2.2
Current tobacco smoking	0.6	0.9	2.6	-0.8	-0.3	0.7	-1.6
Average weekly fortified wine intake	0.3	0.3	0.7	-0.4	-0.1	-0.8	0.7
Maternal smoking around birth	0.6	0.9	1.5	0.8	-1.1	-1.2	-0.5
Fed-up feelings	0.8	1.5	3.2	-0.2	-1.6	-1.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	0.3	-0.3	-1.1	1.1
Relative age voice broke	0.5	0.8	1.9	-0.2	1.2	1.4	-0.0
Taking other prescription medications	1.1	1.7	3.0	-0.1	-1.7	-1.2	1.6
Age when periods started (menarche)	0.6	1.5	2.8	-1.2	-1.7	-0.9	-0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.3	0.0	-1.5	-1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	6.8	-1.1	0.1	1.9	-2.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.1	-1.2	0.0	0.9	-1.8
Qualifications: CSEs or equivalent	0.6	0.7	2.7	-0.3	-0.3	-0.3	-1.6
Serious illness, injury or assault to yourself	0.7	0.8	2.6	-0.1	0.3	0.7	1.6
High blood pressure	0.4	1.0	3.1	0.3	-1.8	0.2	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-1.0	-0.1	0.1	-0.6
Multivitamins +/- minerals	0.2	0.2	0.6	0.8	0.3	0.0	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.7	-0.3	0.4	-0.3
Supplements: Glucosamine	1.5	2.0	3.8	1.3	1.3	2.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	-0.8	-0.7	-0.6	-0.0
Medication: Atenolol	0.7	0.9	2.6	0.6	0.8	1.6	0.0
Medication: Levothyroxine sodium	1.4	2.5	5.2	-2.3	-0.6	-1.9	0.7
Sitting height	1.6	11.1	38.4	-0.5	-1.5	-6.2	1.8
Chronic bronchitis/emphysema (father)	2.2	2.6	4.5	-1.1	-2.1	-2.0	-0.9
High blood pressure (mother)	0.0	0.0	0.1	-0.3	0.1	-0.3	0.1
Body mass index (BMI)	0.0	0.1	0.3	-0.3	-0.5	0.1	0.3
Impedance of leg (left)	0.1	0.5	1.7	1.3	0.5	0.4	-0.1
Leg predicted mass (left)	1.0	5.1	14.1	-1.2	-1.8	-3.8	1.3
Trunk fat mass	0.6	2.4	6.2	-0.1	-1.3	-2.5	1.3
Waist circumference	0.3	1.2	2.8	-0.5	-0.8	-1.7	1.1
Number of incorrect matches in round	0.5	0.8	2.0	0.6	-0.4	-1.4	-0.7
Past tobacco smoking	0.2	0.4	1.3	-0.3	-0.2	-0.2	-1.1
Alcohol usually taken with meals	0.6	1.0	2.7	0.3	1.6	0.9	0.5
Nervous feelings	0.2	0.5	1.6	1.2	-0.2	0.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.5	0.4	-1.2	-2.1	0.4
Hearing difficulty/problems with background noise	1.6	2.6	5.4	1.5	0.7	-1.4	2.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.7	-0.4	-0.4	-0.8
Had menopause	1.4	1.7	2.4	1.0	1.4	1.2	1.6
Had other major operations	1.0	1.3	3.5	-0.8	-0.2	-1.9	-1.0
Forced vital capacity (FVC)	0.7	2.7	7.1	-0.7	-0.3	-2.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.9	-0.6	0.2	2.0	-1.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.1	-0.2	0.2	-0.8
Qualifications: None of the above	0.4	0.8	1.9	-0.2	-1.4	-0.9	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.3	0.4	0.2	-0.2	-0.5
Mouth/teeth dental problems	0.2	0.4	0.8	-0.9	-0.3	0.4	-0.5
Heart attack	1.4	1.7	4.3	1.2	1.1	2.1	0.1
Allergy	1.4	3.2	8.1	2.9	0.6	-0.5	2.0
Pain all over the body in last month	0.4	0.4	0.9	-0.7	-0.9	-0.4	0.1
Diabetes (self-reported)	1.9	2.9	3.9	1.8	1.1	-1.8	2.0
Hayfever/allergic rhinitis (self-reported)	3.8	5.1	8.8	-3.0	-2.3	-0.9	-2.3
Medication: Ramipril	0.2	0.2	0.8	0.9	-0.4	-0.1	0.0
Medication: Simvastatin	0.5	0.8	1.6	1.1	0.6	1.3	0.1
Fluid intelligence score	0.5	1.0	2.0	-1.4	0.7	1.0	-0.7
Illnesses of siblings	0.1	0.1	0.4	0.1	-0.6	0.2	0.2
Neuroticism score	0.2	0.5	1.4	1.2	-0.1	-0.6	0.4
Weight	0.9	4.3	11.7	-0.8	-1.6	-3.4	1.5
Impedance of arm (right)	0.1	0.6	1.6	0.5	0.3	-1.3	-0.5
Arm fat percentage (right)	0.0	0.2	0.3	-0.3	-0.3	-0.6	0.5
Trunk fat-free mass	1.0	5.7	14.1	-1.4	-2.1	-3.8	1.5
Hip circumference	0.7	3.2	7.2	-1.2	-1.8	-2.7	0.8
Time employed in main current job	1.6	1.9	3.0	-1.6	-1.7	-0.5	-1.3
Alcohol intake versus 10 years previously	0.5	0.8	2.7	0.2	-0.5	-1.6	0.2
Father’s age at death	1.0	1.3	3.6	-0.1	0.5	-1.9	1.2
Worrier / anxious feelings	0.1	0.2	0.7	-0.0	0.2	0.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.0	-0.2	0.3	0.5
Falls in the last year	1.6	2.1	7.5	0.7	0.8	0.2	2.7
Hair/balding pattern: Pattern 3	1.0	1.5	4.0	0.2	1.4	2.0	-0.5
Number of live births	0.9	1.3	3.6	0.3	-0.8	-1.9	1.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	6.8	0.4	0.7	-2.3	2.6
Pulse rate	0.4	0.6	2.1	-0.7	-0.1	1.4	-0.2
Happiness	0.1	0.1	0.4	-0.6	0.0	0.3	-0.2
Noisy workplace	0.1	0.1	0.2	0.1	-0.5	0.1	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.8	-0.5	1.4	0.6	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	0.7	0.6	-0.5	0.9
Mouth/teeth dental problems: Dentures	0.9	1.6	4.1	0.9	-0.4	-2.0	1.1
Asthma	3.9	7.8	19.4	-4.4	-1.9	-0.7	-2.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	0.8	-1.1	-1.2	-0.4
Medication: Cholesterol lowering	0.5	0.8	2.5	0.7	0.4	1.6	-0.2
Depression (self-reported)	1.4	1.7	5.4	0.8	-0.8	-2.3	0.1
Medication: Lansoprazole	0.5	0.6	1.9	-0.1	-1.4	0.4	0.4
Prospective memory result	1.0	1.3	3.9	0.9	-0.1	-2.0	0.6
Lung cancer (father)	0.1	0.1	0.3	0.6	-0.2	-0.2	0.0
Illnesses of mother	0.2	0.3	0.7	-0.9	-0.5	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	8.9	0.7	0.9	-2.5	3.0
Pulse wave Arterial Stiffness index	1.0	1.2	3.6	1.1	0.2	-0.0	1.9
Impedance of arm (left)	0.1	0.4	1.1	0.3	0.5	-1.1	-0.5
Arm fat mass (right)	0.2	0.9	2.1	-0.4	-0.7	-1.4	1.0
Trunk predicted mass	1.0	5.6	13.8	-1.3	-2.1	-3.7	1.5
Standing height	1.8	18.1	58.2	-1.0	-2.5	-7.6	2.6
Length of working week for main job	0.9	1.0	2.0	1.4	0.4	-0.8	1.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.5	0.1	-0.1	-0.2
Breastfed as a baby	0.7	0.9	1.8	-0.1	1.3	1.3	0.3
Tense / ‘highly strung’	0.8	1.3	3.3	1.8	0.2	-1.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	2.9	1.7	1.4	-1.4	1.3
Hair/balding pattern: Pattern 4	4.1	9.8	14.0	2.4	3.5	3.7	2.7
Birth weight of first child	1.4	2.6	6.9	-0.3	1.8	2.6	-0.5
Peak expiratory flow (PEF)	1.0	2.3	6.8	0.3	-0.3	-2.6	1.5
Pulse wave reflection index	0.3	0.3	0.6	-0.4	-0.5	-0.6	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.9	-0.3	0.2	0.2
Loud music exposure frequency	0.9	1.0	1.9	-1.0	-0.8	-0.5	-1.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.5	0.3	1.9	1.1	0.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.7	-0.2	1.5	2.2	-0.4
Blood clot in the leg (DVT)	0.7	0.9	1.8	-0.4	0.4	1.4	-1.2
Medication: Paracetamol	1.5	2.5	6.2	-0.2	-2.5	-1.5	-1.2
Headache pain in last month	0.9	1.6	2.9	-0.7	-1.6	-0.6	-1.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	-0.0	0.5	-1.1	0.7
Glaucoma (self-reported)	0.5	0.5	1.1	1.1	0.3	0.7	-0.7
Gout (self-reported)	0.3	0.4	0.9	0.9	-0.4	-0.5	0.5
Hypothyroidism/myxoedema (self-reported)	2.8	5.4	9.6	-2.8	-2.0	-3.1	-0.3
Medication: Amlodipine	1.4	2.0	3.4	-1.1	-0.9	1.8	-1.7
Medication: Ventolin 100micrograms inhaler	2.5	3.2	6.8	-2.6	-2.0	-1.1	-0.9
Birth weight	0.3	0.7	1.7	-0.2	-0.5	-1.3	1.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	5.4	0.1	-1.2	-0.6	-2.3
High blood pressure (siblings)	0.6	0.8	1.6	-0.4	-1.0	-1.3	-0.6
Forced vital capacity (FVC), Best measure	1.0	3.8	10.6	-0.6	-0.2	-3.2	2.0
Body fat percentage	0.1	0.5	0.9	0.3	-0.5	-0.9	0.9
Leg fat percentage (right)	0.1	0.2	0.4	0.3	-0.4	0.6	0.5
Arm fat-free mass (right)	0.9	4.8	12.2	-0.7	-1.9	-3.5	1.8
Exposure to tobacco smoke outside home	3.0	4.0	5.7	2.1	2.4	1.6	1.9
Comparative body size at age 10	0.1	0.2	0.3	-0.2	-0.5	0.6	0.5
Number of full brothers	1.9	2.4	5.7	0.9	-1.6	-2.4	0.6
Worry too long after embarrassment	0.9	1.5	4.1	2.0	0.2	-0.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	3.4	1.4	1.9	-0.4	1.1
Wheeze or whistling in the chest in last year	1.2	2.2	5.7	-2.4	-0.6	0.7	-1.4
Number of children fathered	0.2	0.2	0.3	0.6	-0.3	0.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.2	-0.4	-0.5	0.2	-1.5
Age at first live birth	1.3	2.4	6.2	0.0	1.7	2.5	0.6
Pulse wave peak to peak time	1.0	1.2	3.0	-1.1	-0.4	-0.6	-1.7
Health satisfaction	0.2	0.3	0.5	-0.3	-0.6	-0.7	0.4
Shortness of breath walking on level ground	1.2	1.4	2.7	-0.5	-1.4	-1.6	-0.8
Qualifications: College or University degree	0.4	1.4	1.9	-0.3	1.3	1.3	1.4
Eye problems/disorders: None of the above	2.2	2.6	7.3	-1.4	-1.1	-0.2	-2.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.8	-0.3	0.1	-0.2
Emphysema/chronic bronchitis	0.8	0.9	1.8	-0.0	-1.4	-1.3	0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	4.6	1.2	2.1	0.0	1.6
Neck or shoulder pain in last month	0.6	0.8	1.8	1.0	0.5	-0.6	1.3
Medication: Blood pressure	0.3	0.5	1.2	0.3	-0.5	1.1	-0.6
Angina (self-reported)	0.5	0.7	1.7	-0.1	-1.0	0.1	-1.3
Migraine (self-reported)	2.0	2.5	6.6	1.6	0.9	2.6	0.6
Medication: Ibuprofen	1.5	1.8	4.8	1.0	-1.0	-2.2	0.4
Medication: Allopurinol	0.8	1.1	2.2	1.0	-0.9	-1.5	0.5
Medication: Omeprazole	0.2	0.2	0.5	-0.7	0.1	0.0	-0.6
Medication: Seretide 50 evohaler	0.8	0.9	2.2	-0.3	-1.5	-1.1	-0.1
Mean time to correctly identify matches	0.2	0.3	0.7	-0.8	0.6	0.4	-0.0
Heart disease (mother)	0.8	0.9	1.7	0.8	-1.2	-1.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.0	-0.2	0.6	0.2
Whole body fat mass	0.5	2.2	5.6	0.1	-1.2	-2.4	1.4
Leg fat mass (right)	0.2	0.7	1.2	0.4	-0.8	-1.1	1.0
Arm predicted mass (right)	0.8	4.3	10.3	-0.9	-2.0	-3.2	1.4
Pulse rate, automated reading	0.4	1.2	4.2	-0.0	-2.0	0.0	-0.9
Alcohol intake frequency.	0.7	1.5	2.9	1.5	-0.8	-1.7	0.7
Comparative height size at age 10	1.2	6.4	18.7	-0.9	-2.4	-4.3	0.6
Number of full sisters	0.3	0.4	1.3	-0.0	0.6	-0.2	-1.1
Suffer from ‘nerves’	0.5	0.8	2.4	1.6	0.5	-0.4	0.5
Overall health rating	0.2	0.3	1.0	0.3	-0.3	-0.3	1.0
Chest pain or discomfort	0.2	0.3	1.0	-0.2	-0.5	1.0	-0.4
Had major operations	0.4	0.5	1.3	0.4	-1.1	-0.6	-0.2
Age at last live birth	0.3	0.4	0.9	-0.9	0.3	0.8	-0.5
Family relationship satisfaction	0.0	0.0	0.1	-0.2	0.1	-0.4	0.1
Leg pain on walking	0.4	0.5	1.6	0.2	0.7	0.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	1.0	-0.0	-0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	-0.0	-1.0	-1.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.4	-0.9	0.1	1.6	-0.7
Medication: Aspirin	0.6	0.8	2.1	-0.8	-0.3	1.4	-0.5
Supplements: Vitamin C	0.4	0.4	0.7	0.7	0.7	0.8	0.5
Knee pain experienced in last month	0.1	0.2	0.5	0.2	0.1	-0.4	0.7
Hypertension (Self-reported)	0.6	1.5	5.1	-0.0	-2.2	-0.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.0	-0.7	-0.7	1.3	-1.4
Illnesses of father: Heart disease	2.4	3.4	10.3	0.7	1.7	3.2	0.1
Illnesses of siblings: Diabetes	1.1	1.3	2.3	0.3	0.8	-1.5	1.5
Smoking status: Previous	1.0	1.5	4.6	0.9	0.2	-0.6	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	9.2	0.6	-0.9	-3.0	1.0
Whole body fat-free mass	1.0	6.0	15.4	-1.4	-2.1	-3.9	1.5
Leg fat-free mass (right)	1.1	5.7	16.1	-1.4	-1.7	-4.0	1.3
Arm fat percentage (left)	0.0	0.2	0.2	-0.4	-0.5	-0.4	0.3
Average weekly red wine intake	0.6	1.0	2.0	-0.4	-0.7	-1.4	1.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.1	0.9	1.0	1.0	0.9
Mood swings	0.5	1.0	1.6	1.1	-0.5	-1.2	1.0
Loneliness, isolation	0.6	0.8	2.1	1.5	-0.2	-0.5	0.9
Long-standing illness, disability or infirmity	1.6	2.5	6.0	0.8	-0.3	-2.5	1.8
Ever had bowel cancer screening	0.5	0.6	1.5	-0.2	0.6	-0.8	1.2
Diabetes diagnosed by doctor	1.4	2.4	4.0	2.0	1.3	-1.0	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.4	1.8	0.4	-1.0	0.9
Friendships satisfaction	0.8	1.0	2.7	-1.6	0.0	1.0	-0.6
Qualifications: nursing, teaching	0.3	0.5	1.0	0.1	1.0	0.5	0.7
Commuting to job workplace: Walk	1.0	1.0	2.9	-1.7	-0.4	0.4	-1.0
Eye problems/disorders: Cataract	1.5	1.7	5.2	1.0	0.5	-0.6	2.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	-0.6	0.6	0.5	-0.5
Medication for cholesterol	0.5	0.8	2.8	0.4	0.2	-0.4	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.3	0.2	0.1	1.5	-0.2
Back pain experienced in last month	0.4	0.6	1.3	-0.1	-1.1	-1.0	0.4
Mineral and other dietary supplements	0.7	0.9	2.1	-0.6	-0.6	-1.5	-0.9
Breast cancer (self-reported)	0.3	0.4	1.2	-0.3	-0.0	0.3	-1.1
Asthma (self-reported)	4.4	8.7	19.4	-4.4	-2.3	-1.0	-3.0
Osteoporosis (self-reported)	0.4	0.6	1.0	-1.0	-0.7	-0.5	0.6
Osteoarthritis (self-reported)	1.4	1.9	3.4	1.5	1.0	-1.0	1.8
Medication: Aspirin	0.7	0.9	3.5	-0.3	0.1	1.9	-0.4
Medication: Gliclazide	2.3	2.6	4.5	1.2	2.1	1.5	1.5
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	1.0	0.9	-0.9	1.2
Smoking status: Current	0.8	1.2	3.2	-1.0	-0.3	0.8	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.3	0.8	1.3	-0.9	2.5
Whole body water mass	1.0	5.7	14.7	-1.4	-2.0	-3.8	1.5
Leg predicted mass (right)	1.1	5.7	15.9	-1.5	-1.8	-4.0	1.2
Arm fat mass (left)	0.2	0.9	1.9	-0.3	-0.7	-1.4	1.0
Number of self-reported non-cancer illnesses	0.8	1.3	3.1	-0.3	-1.3	-1.8	0.5
Average weekly champagne plus white wine intake	0.8	1.1	1.7	-1.0	0.9	1.3	-0.9
Miserableness	0.4	0.7	1.3	0.1	-0.8	-1.1	0.8
Guilty feelings	1.7	2.6	6.2	2.5	0.0	-1.5	1.3
Wears glasses or contact lenses	0.3	0.3	0.4	-0.3	0.6	0.6	0.7
Ever taken oral contraceptive pill	0.5	0.6	1.1	0.5	-1.1	-0.3	-0.9
Hearing aid user	1.3	1.4	3.2	0.7	-0.4	-1.8	1.4
Mother’s age at death	0.4	0.5	1.0	-1.0	0.2	-0.2	-0.9
Financial situation satisfaction	0.7	0.9	1.5	0.6	-1.2	-1.2	0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	-0.0	0.3	-0.2	1.1
Commuting to job workplace: Public transport	1.8	2.2	6.2	0.3	1.6	2.5	0.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	0.7	0.5	1.1	-0.3
Medication: Blood pressure	0.5	1.0	2.3	-0.6	-1.0	0.6	-1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.6	0.6	1.0	1.3	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.8	1.3	1.1	0.3	1.3
High cholesterol (Self-reported)	0.3	0.6	1.0	1.0	0.9	0.5	0.6
Medication: Bendroflumethiazide	1.1	1.6	3.5	0.2	-1.2	1.2	-1.9
Medication: Paracetamol	1.5	2.3	4.6	0.3	-2.0	-2.1	-0.4
Medication: Lisinopril	0.5	0.7	2.1	-0.6	-1.4	0.3	-0.3
Medication: Atorvastatin	0.5	0.7	1.4	-0.8	-0.1	1.2	-0.7
Illnesses of father: High blood pressure	0.8	1.0	2.4	-1.5	-0.5	0.5	-1.0
Alcohol drinker status: Never	0.4	0.5	1.2	1.1	-0.0	0.8	0.1
Ever smoked	0.0	0.1	0.1	-0.2	0.2	0.2	0.4
Basal metabolic rate	1.0	5.5	14.7	-1.2	-1.9	-3.8	1.5
Leg fat percentage (left)	0.1	0.3	0.7	0.4	-0.4	0.4	0.8
Arm fat-free mass (left)	0.8	3.9	9.6	-0.4	-1.2	-3.1	2.0
Number of operations (self-reported)	1.2	1.8	5.0	-0.0	-1.2	-2.2	-0.9
Average weekly beer plus cider intake	1.0	1.4	2.6	-1.3	-0.6	1.0	-1.6
Irritability	0.2	0.4	0.7	-0.3	-0.9	-0.3	-0.8
Risk taking	0.2	0.2	0.6	0.2	-0.4	-0.4	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-0.1	-0.5	-1.0	-0.5
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.3	0.7	0.0	0.6
Age started oral contraceptive pill	0.4	0.5	0.7	0.7	0.7	0.6	0.8
Diastolic blood pressure, automated reading	2.8	8.5	15.0	-2.7	-3.1	-3.9	-1.5
Ever depressed for a whole week	0.4	0.5	0.7	0.8	0.8	0.8	-0.4
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.4	-0.2	0.2	-0.0
Commuting to job workplace: Cycle	1.1	1.3	2.7	-0.5	1.5	0.1	1.6
Myopia	0.2	0.3	1.1	-0.1	1.0	0.4	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.0	-0.4	1.4	-0.5	1.2
Cholesterol lowering medication	0.5	0.7	1.8	-0.8	0.4	1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	-0.8	-0.4	0.2	-0.7
Pain experienced in last month	0.1	0.1	0.3	0.3	0.4	0.1	0.5
Supplements: Calcium	0.2	0.2	0.4	-0.0	-0.6	0.2	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.5	-1.2	-0.4	-1.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.3	1.4	0.9	2.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-0.8	-0.1	0.7	-1.6
Heart disease (siblings)	0.8	1.0	2.1	1.4	1.2	0.4	0.6
Alcohol drinker status: Previous	3.0	3.4	5.2	-2.3	-1.3	-2.0	-1.7
Pack years of smoking	0.2	0.2	0.8	0.3	0.1	-0.3	-0.9
Impedance of whole body	0.1	0.5	1.1	1.1	0.5	-0.5	-0.5
Leg fat mass (left)	0.3	1.0	1.7	0.3	-0.8	-1.3	1.3
Arm predicted mass (left)	0.8	4.0	9.9	-0.4	-1.2	-3.1	2.1