TWAS hub - ARHGEF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.2980	0.0860	1.1e-03	0.002	NA	0.048	NA	0.048	2.8e-01	NA	2.9e-02	NA	2.9e-02
2	GTEx	Esophagus Mucosa	0.1200	0.0470	3.2e-03	0.056	NA	0.033	NA	0.014	1.3e-04	NA	2.7e-03	NA	3.5e-02
3	GTEx	Vagina	0.3260	0.1160	3.2e-03	0.063	NA	0.123	NA	0.102	1.5e-02	NA	9.8e-04	NA	2.5e-03
4	NTR	Blood	0.0392	0.0137	2.2e-04	0.007	0.011	0.015	0.013	0.015	2.4e-03	1.4e-04	9.1e-06	2.5e-05	1.1e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.3682	0.0456	0.0e+00	0.281	0.263	0.269	0.292	0.278	3.2e-36	1.2e-33	1.3e-34	6.6e-38	7.8e-36
6	YFS	Blood	0.1273	0.0292	6.1e-14	0.035	0.055	0.048	0.066	0.049	1.2e-11	1.8e-17	2.2e-15	1.5e-20	1.3e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	14.7	170.8	470.9	7.9	-16.5	-0.3	-14.8	-0.3	-21.7
Ever unenthusiastic/disinterested for a whole week	3.2	4.0	7.4	-2.1	-0.5	1.3	-2.5	-2.0	-2.7
Mouth/teeth dental problems: Bleeding gums	3.1	4.1	8.2	-1.5	-1.4	1.2	-2.6	-1.9	-2.9
Blood Red Count	2.8	27.5	70.1	-0.8	1.8	-5.5	7.8	0.7	8.4
Heel T-Score	2.6	21.1	70.2	1.1	4.9	3.1	4.6	8.4	0.2
Glaucoma (self-reported)	2.5	3.0	5.9	1.6	-1.1	-1.5	2.4	1.2	2.1
Osteoarthritis (self-reported)	2.5	3.2	14.1	3.8	1.5	-0.1	0.3	1.7	0.5
High blood pressure (mother)	2.4	3.4	9.7	-1.5	-0.1	-0.5	2.7	0.9	3.1
Pulse wave Arterial Stiffness index	2.4	2.8	6.6	-0.1	1.3	-1.1	2.2	2.6	1.5
Illnesses of father: Heart disease	2.4	3.4	6.5	-2.0	-1.7	0.4	-2.5	-2.3	-1.2
Bipolar Disorder or Schizophrenia	2.3	5.7	16.0	-0.8	4.0	1.0	2.5	2.3	2.2
Length of working week for main job	2.3	2.6	5.9	-0.7	-2.4	0.4	-1.4	-1.2	-2.4
Commuting to job workplace: Walk	2.3	2.4	6.4	-0.7	1.5	1.8	-1.5	0.2	-2.5
Type 2 Diabetes (T2D) (2012)	2.2	2.6	6.4	0.1	-0.9	-2.5	2.4	1.0	1.3
Medication: Omeprazole	2.2	2.6	6.2	0.8	0.7	1.6	-1.8	1.5	-2.5
Neck or shoulder pain in last month	2.1	3.0	6.8	1.6	-0.6	2.6	1.7	2.2	0.5
Bipolar Disorder (2018)	2.0	3.2	5.9	-0.4	2.0	1.7	2.4	1.8	1.7
Schizophrenia (2014)	2.0	4.4	14.7	0.3	3.8	-0.4	2.0	2.2	1.6
Eye problems/disorders: Cataract	2.0	2.3	9.8	3.1	1.3	0.9	-0.2	0.8	0.7
Medication: Co-codamol	1.9	2.2	7.2	-2.7	-0.9	1.7	-0.8	-0.2	-1.1
Pulse wave peak to peak time	1.9	2.2	6.7	0.1	-1.6	0.5	-1.6	-2.6	-1.0
Myopia	1.9	2.8	8.3	0.1	0.6	-1.6	2.2	0.7	2.9
HbA1C	1.8	2.0	4.1	-1.0	-1.0	-0.1	-2.0	-1.9	-1.4
Lung FEV1/FVC ratio	1.8	9.3	21.2	-2.1	0.9	-3.9	3.8	-0.7	4.6
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	3.7	-1.9	-1.6	0.1	-1.6	-1.9	-0.4
Overall health rating	1.8	3.8	8.6	2.1	1.1	0.3	2.9	2.7	1.1
Supplements: Vitamin C	1.8	2.1	4.8	1.6	2.2	-2.0	0.6	1.1	-0.1
Commuting to job workplace: Public transport	1.8	2.1	5.3	-1.7	-2.3	-1.4	-0.6	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	1.8	2.4	3.2	1.7	1.6	-1.8	1.6	1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.1	0.7	1.0	1.6	-1.4	2.0	-1.8
Pain experienced in last month	1.8	3.0	12.6	-3.6	0.2	-0.4	-1.2	-1.8	-0.8
Hayfever, allergic rhinitis or eczema	1.7	3.6	8.0	-1.2	-2.8	-1.4	1.1	-2.3	2.0
Number of incorrect matches in round	1.7	2.8	5.6	2.3	0.7	1.1	-1.4	2.4	-1.5
Had menopause	1.7	2.1	5.2	1.9	0.9	0.7	1.1	2.3	1.3
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	5.8	-0.3	-2.4	-1.0	-1.6	-1.9	-0.6
Prospective memory result	1.7	2.1	9.6	-0.5	1.7	0.4	0.2	3.1	0.0
Birth weight of first child	1.7	3.0	11.8	-1.0	-0.9	-3.4	1.9	-0.6	-0.7
Hair/balding pattern: Pattern 2	1.6	2.1	5.5	-0.8	-2.3	-1.1	-1.2	-0.4	-1.9
Hair/balding pattern: Pattern 3	1.6	2.4	4.2	1.3	1.9	1.1	1.3	1.4	2.0
Illnesses of mother	1.6	1.9	4.7	-0.0	-1.9	0.3	-2.2	-0.9	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	10.6	-1.4	-0.6	-2.7	3.2	-0.0	3.2
Loud music exposure frequency	1.6	1.8	4.9	-1.9	-0.1	0.8	-1.2	0.2	-2.2
Eye problems/disorders: None of the above	1.6	1.9	7.6	-2.8	0.8	-1.0	-0.2	-1.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	7.2	0.4	0.3	-0.7	-1.4	1.2	-2.7
Hypertension (Self-reported)	1.6	4.6	8.3	0.9	2.1	2.1	2.9	1.9	2.4
Mother’s age at death	1.6	2.0	3.5	1.4	-0.1	-0.7	1.8	1.6	1.9
Schizophrenia (2018)	1.5	3.2	12.4	-0.6	3.5	-0.1	1.3	1.6	1.4
Crohns Disease (2012)	1.5	2.5	8.0	-1.2	-0.1	-2.8	1.3	-0.4	1.9
Allergy or Eczema	1.5	4.0	8.7	-0.1	-3.0	-1.7	1.4	-1.9	2.6
Sensitivity / hurt feelings	1.5	2.5	10.0	0.5	1.0	3.2	-1.5	-0.4	-1.3
Angina	1.5	1.9	5.5	-0.9	0.4	0.6	2.4	0.9	2.0
Multivitamins +/- minerals	1.5	1.9	5.0	0.8	2.2	-2.1	-0.0	1.1	0.2
Medication: Simvastatin	1.5	2.2	5.1	0.1	-0.8	1.6	2.3	1.6	1.7
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	9.4	-2.4	-1.7	-2.2	3.1	-0.2	2.8
Medication: Blood pressure	1.5	2.6	6.0	-1.1	1.5	2.4	1.9	0.3	1.5
Age at last live birth	1.5	2.1	6.3	-1.2	-2.5	-0.4	-0.2	-2.2	-0.1
Back pain experienced in last month	1.5	2.2	3.8	1.2	-0.0	1.4	1.6	1.9	1.9
Primary Biliary Cirrhosis	1.4	2.0	6.5	-1.4	1.0	-0.4	2.6	1.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	12.2	0.2	2.0	0.1	1.4	3.5	-0.9
High blood pressure	1.4	4.0	8.5	0.6	2.0	1.9	2.9	1.7	2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	12.0	0.5	2.0	0.5	1.3	3.5	-1.3
Fluid intelligence score	1.4	2.9	11.7	-0.3	-2.1	-0.7	-0.3	-3.4	0.6
Depression (self-reported)	1.4	1.7	5.1	0.7	1.4	0.7	0.9	2.3	-1.1
Number of full brothers	1.4	1.7	3.6	-0.2	1.2	-0.7	1.8	1.2	1.9
Number of children fathered	1.4	1.6	3.3	-1.8	-0.7	0.4	-1.7	-0.9	-1.3
Angina (self-reported)	1.4	1.9	5.8	-0.9	0.3	0.4	2.4	0.9	1.9
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.4	0.4	1.4	-1.6	1.2	0.8	1.9
Medication: Lisinopril	1.4	1.8	3.7	1.2	-0.3	1.4	1.9	0.6	1.9
Schizophrenia vs Biploar Disorder	1.3	1.7	5.5	-0.5	0.3	-2.0	-2.3	-0.1	-0.7
Neuroticism	1.3	3.0	12.8	0.9	1.0	3.6	-1.1	0.4	-1.4
Vitamin and mineral supplements	1.3	1.7	4.1	-1.0	-1.8	2.0	0.9	-0.9	0.3
Maternal smoking around birth	1.3	1.9	6.8	-0.4	-0.2	2.6	-0.9	1.4	-1.4
Standing height	1.3	13.3	25.3	-1.9	-5.0	-4.2	3.4	-3.5	3.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.0	1.7	-0.1	-1.5	-2.2	-0.7	-1.5
Medication: Ventolin 100micrograms inhaler	1.3	1.7	7.5	0.8	0.4	-2.7	-0.3	-0.7	1.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.5	-0.3	0.3	1.5	-1.9	-0.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	9.9	-0.5	-3.1	-1.8	-0.2	-1.6	0.4
Ever taken oral contraceptive pill	1.3	1.4	2.4	0.3	-1.2	0.6	-1.5	-1.5	-1.4
Vascular/heart problems diagnosed by doctor	1.3	3.6	7.1	-0.2	-1.6	-1.9	-2.7	-1.1	-2.7
Crohns Disease (2017)	1.2	2.7	8.1	-0.6	-0.1	-2.8	1.4	-0.9	2.3
Verbal and Numeric Reasoning (VNR)	1.2	2.8	7.7	-0.2	-2.2	-2.0	0.1	-2.8	0.6
Bipolar Disorder (2011)	1.2	1.2	2.7	-0.9	0.1	0.6	1.6	1.2	1.2
Coronary Artery Disease (CAD)	1.2	1.4	4.3	0.6	-0.3	-0.9	2.1	0.9	1.5
Systolic Blood Pressure	1.2	5.9	15.6	-1.0	1.4	1.9	3.5	-0.8	4.0
Ever had hysterectomy (womb removed)	1.2	1.4	3.3	-0.9	0.8	1.8	-0.9	-0.6	-1.6
Diabetes (mother)	1.2	1.5	4.4	-1.2	1.2	2.1	1.2	0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.2	-0.4	-0.0	0.8	-1.5	-1.1	-2.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	6.7	0.9	0.7	2.6	0.0	0.9	-1.5
Allergy	1.2	2.8	6.6	0.5	2.2	1.7	-0.5	2.6	-1.3
Exposure to tobacco smoke at home	1.2	1.3	2.9	1.4	0.7	-1.7	0.1	-0.1	1.6
Peak expiratory flow (PEF)	1.2	2.9	5.4	-1.1	-2.3	-2.0	0.7	-0.9	2.3
Qualifications: College or University degree	1.2	3.8	10.8	0.4	1.0	-1.6	3.3	-0.3	2.8
Suffer from ‘nerves’	1.2	1.8	4.6	1.4	2.1	-0.0	0.2	1.8	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	4.9	0.4	2.2	0.5	-0.7	1.4	-0.9
Osteoporosis (self-reported)	1.2	1.4	2.7	-1.0	-1.4	1.7	0.5	-0.6	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	6.2	-1.2	0.2	-2.5	1.9	0.6	2.0
Average weekly champagne plus white wine intake	1.2	1.6	5.1	-1.4	-2.3	0.1	-0.7	-1.2	-0.9
Depressed Affect (Nagel 2018)	1.1	2.4	4.4	1.6	1.8	2.1	-1.4	-0.5	-1.3
Number of treatments/medications taken	1.1	2.0	4.2	1.7	0.2	-0.6	2.1	1.4	1.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.4	1.5	1.3	-0.0	-0.4	2.1	0.1
Trunk fat-free mass	1.1	6.1	15.8	-2.2	-4.0	-3.1	1.7	-1.8	0.8
Alcohol intake versus 10 years previously	1.1	1.7	3.8	1.3	2.0	0.0	-0.2	1.1	-1.8
Falls in the last year	1.1	1.5	3.8	1.9	0.1	-0.3	1.1	0.9	1.7
Medication: Cholesterol lowering	1.1	1.7	5.2	-2.3	0.3	1.2	1.6	0.5	0.7
Trunk predicted mass	1.1	6.2	16.8	-2.2	-4.1	-3.0	1.8	-1.8	0.8
Tense / ‘highly strung’	1.1	1.9	4.8	0.4	1.8	2.2	-0.3	0.6	-1.7
Hair/balding pattern: Pattern 4	1.1	2.6	10.3	-3.2	1.7	0.6	-1.1	-0.5	-0.6
Birth weight	1.1	2.4	8.0	-1.7	-1.2	-2.8	0.6	-1.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.8	0.5	-0.6	-0.1	2.0	1.5	0.8
Medication: Aspirin	1.1	1.4	3.4	-0.4	0.1	1.6	1.9	0.7	1.3
Breast cancer (self-reported)	1.1	1.3	2.8	1.4	0.6	0.6	-1.7	-0.2	-1.4
Ever smoked	1.1	2.0	5.0	-1.8	-0.9	2.2	-1.2	-0.8	-0.8
Basal cell carcinoma (self-reported)	1.1	1.3	4.7	0.1	0.2	-0.1	1.6	0.8	2.2
Height	1.0	19.4	54.2	-3.4	-7.4	-4.5	3.5	-4.1	1.3
Medication: Atenolol	1.0	1.3	2.2	0.2	1.3	-1.1	0.7	1.5	1.5
Medication: Lansoprazole	1.0	1.1	5.0	1.0	0.4	-0.0	0.8	2.2	0.0
High blood pressure (siblings)	1.0	1.5	3.0	-1.7	-1.0	1.0	1.3	0.4	1.4
Emphysema/chronic bronchitis	1.0	1.1	2.2	0.3	-1.4	-0.1	-0.8	-1.3	-1.5
Mean time to correctly identify matches	1.0	2.0	6.9	0.8	2.6	0.7	0.6	1.8	0.4
Number of full sisters	1.0	1.2	3.3	0.9	1.7	0.4	0.1	1.8	0.6
Mood swings	1.0	1.8	5.2	2.3	1.5	1.0	-0.7	1.1	-0.6
Friendships satisfaction	1.0	1.2	6.4	-2.5	0.4	0.7	-0.1	-0.3	0.3
Mineral and other dietary supplements	1.0	1.3	3.1	-1.3	-1.1	1.8	-0.6	-0.4	-1.1
Smoking status: Current	1.0	1.5	5.5	1.1	-0.2	2.3	0.4	0.0	-1.6
Miserableness	1.0	1.8	4.7	0.5	0.2	2.2	-1.9	-0.6	-1.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	1.6	-1.7	0.1	0.9	-0.2	1.1
Intelligence (Savage-Jansen 2018)	0.9	2.6	6.8	-0.3	-2.1	-1.7	-1.0	-2.6	0.7
Breast Cancer	0.9	2.1	5.6	-2.4	-1.1	1.4	0.4	-1.6	0.7
Ovarian Cancer	0.9	1.1	4.9	-1.1	-2.2	-0.0	0.1	-0.8	0.4
Cardiovascular Disease	0.9	3.1	8.3	-0.4	0.4	1.3	2.8	0.6	2.9
Systolic blood pressure, automated reading	0.9	2.6	5.8	-0.0	2.4	0.6	2.3	0.7	2.0
Severe depression (siblings)	0.9	1.0	2.2	-0.8	-0.5	1.5	-1.2	-0.8	-0.9
Average weekly fortified wine intake	0.9	1.1	3.2	-1.2	1.8	-0.5	1.0	-0.5	-0.5
Serious illness, injury or assault to yourself	0.9	1.1	2.6	0.4	-0.7	-1.6	-0.2	-0.9	-1.6
Sitting height	0.9	6.6	14.1	-1.7	-3.5	-2.0	1.7	-3.8	1.9
Breastfed as a baby	0.9	1.1	2.8	1.0	1.0	0.4	0.1	1.7	-1.3
Heart disease (mother)	0.9	1.1	3.2	0.7	1.8	0.5	0.4	0.3	1.6
Whole body fat-free mass	0.9	5.2	15.4	-1.6	-3.9	-2.6	1.8	-1.6	1.0
Whole body water mass	0.9	5.1	15.4	-1.7	-3.9	-2.4	1.7	-1.6	1.0
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.3	-1.3	0.2	1.4	0.7	0.5	1.5
Average weekly beer plus cider intake	0.9	1.3	3.4	0.6	0.2	-0.3	-1.8	1.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.6	-0.1	0.4	1.4	-1.9	0.2	-1.2
Neuroticism (Nagel 2018)	0.8	2.0	6.5	1.3	1.6	2.5	-0.7	-0.2	-0.8
Hypothyroidism (self reported)	0.8	1.8	5.0	-1.7	-0.8	0.6	-0.9	-2.2	-0.9
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.6	-0.1	0.5	1.5	-0.8	-0.3	-1.9
Leg fat-free mass (left)	0.8	4.2	14.1	-0.7	-3.7	-1.8	1.5	-1.7	1.4
Current tobacco smoking	0.8	1.3	5.1	0.9	-0.2	2.2	0.8	0.2	-1.2
Age when periods started (menarche)	0.8	1.9	8.6	1.2	0.1	-2.9	-1.1	0.5	-0.2
Qualifications: CSEs or equivalent	0.8	1.0	3.2	0.8	-0.1	-0.8	-1.8	-0.0	-1.3
Leg predicted mass (left)	0.8	4.2	14.4	-0.7	-3.8	-1.9	1.6	-1.7	1.3
Past tobacco smoking	0.8	1.5	5.3	0.7	0.5	-2.3	1.1	0.6	1.1
Alcohol usually taken with meals	0.8	1.3	4.3	-1.4	0.4	2.1	1.0	0.5	0.2
Mouth/teeth dental problems	0.8	1.3	3.8	0.6	-1.3	-0.7	1.0	-0.2	2.0
Medication: Ramipril	0.8	1.1	4.3	-2.1	0.3	1.1	0.1	-0.8	0.3
Blood clot in the leg (DVT)	0.8	1.0	3.0	-0.1	0.3	1.0	-1.7	0.3	-1.3
Headache pain in last month	0.8	1.4	7.1	0.6	-0.2	2.7	-0.3	-0.1	-1.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	5.4	-1.6	-0.7	0.7	0.1	-2.3	-0.2
Medication: Amlodipine	0.8	1.1	2.4	0.2	0.7	0.9	1.4	0.8	1.6
Forced vital capacity (FVC), Best measure	0.8	3.0	7.5	-0.9	-0.7	-1.9	2.7	0.2	2.4
Comparative body size at age 10	0.8	2.3	11.6	0.4	-0.0	3.4	0.2	-1.3	0.7
Worry too long after embarrassment	0.8	1.4	6.5	0.8	0.4	2.5	-0.5	-0.9	0.5
Health satisfaction	0.8	1.1	1.8	1.2	-1.1	-1.3	0.2	1.4	-0.5
Shortness of breath walking on level ground	0.8	0.9	3.9	0.5	0.1	2.0	0.8	0.7	0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	3.1	-1.3	-0.7	-1.3	-0.7	-1.8	-0.8
Arm predicted mass (right)	0.8	3.9	12.8	-1.4	-3.6	-1.9	1.9	-0.7	1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	1.3	0.8	-0.7	0.7	0.4	1.4
Leg fat-free mass (right)	0.8	4.3	15.0	-0.8	-3.9	-1.7	1.2	-2.0	1.2
Average weekly red wine intake	0.8	1.2	3.4	-0.1	0.8	-0.2	1.9	0.9	1.5
Medication: Aspirin	0.8	1.1	2.4	-0.5	-0.4	1.5	1.6	0.6	0.9
Leg predicted mass (right)	0.8	4.2	15.2	-0.8	-3.9	-1.7	1.2	-2.0	1.2
Financial situation satisfaction	0.8	1.0	3.0	0.1	-1.3	1.7	-0.3	-0.5	-1.1
Medication: Blood pressure	0.8	1.5	4.4	-0.1	-0.0	0.2	2.1	0.5	2.1
Medication: Bendroflumethiazide	0.8	1.2	4.2	-0.2	1.0	-0.5	2.0	0.7	1.1
Alcohol drinker status: Never	0.8	1.0	2.5	0.6	1.6	-1.1	1.1	0.3	0.6
Basal metabolic rate	0.8	4.4	13.2	-1.2	-3.6	-2.3	1.6	-1.5	1.2
Number of operations (self-reported)	0.8	1.2	3.1	-1.5	0.5	0.5	1.8	-0.6	1.0
Diastolic blood pressure, automated reading	0.8	2.4	5.3	-1.4	2.0	-0.8	1.7	0.1	2.3
Alzheimer’s Disease (in father)	0.7	0.8	2.3	0.9	-0.2	-1.0	-0.2	-1.5	0.7
Reaction Time	0.7	1.3	6.3	-0.3	2.5	0.7	0.5	0.9	0.3
Prostate Cancer	0.7	0.9	2.0	-0.7	1.2	-0.3	1.2	1.4	0.5
Age at First Birth	0.7	1.0	3.0	1.1	1.1	-1.7	-0.1	-0.2	-0.6
HDL Cholesterol	0.7	1.1	2.8	0.2	1.1	1.7	-1.2	-0.5	-1.0
Neuroticism (2016)	0.7	1.1	3.5	0.3	-0.4	1.2	-1.9	-0.2	-1.1
Respiratory disease	0.7	1.7	4.3	0.6	-1.7	-1.0	-0.5	-2.1	1.0
Average weekly spirits intake	0.7	0.9	2.9	-0.4	-1.7	-0.7	-0.4	-1.1	0.5
Fed-up feelings	0.7	1.3	4.3	2.1	0.8	1.2	-1.2	-0.5	-0.0
Forced vital capacity (FVC)	0.7	2.8	4.5	-1.9	-2.0	-1.3	2.1	-0.3	1.8
Worrier / anxious feelings	0.7	1.3	2.9	0.7	1.7	0.8	1.6	0.9	0.7
Asthma	0.7	1.3	3.3	0.4	-0.5	-1.8	-0.1	-1.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	1.7	-1.4	0.6	0.1	0.3	-0.0
Lung cancer (father)	0.7	0.8	1.8	1.3	-0.4	-1.1	0.2	-0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.6	0.8	1.3	1.0	0.2	1.2	-1.2
Arm fat-free mass (right)	0.7	3.7	12.3	-1.6	-3.5	-1.6	1.8	-0.9	0.9
Migraine (self-reported)	0.7	0.9	2.5	0.8	0.6	0.1	-1.6	-0.4	-1.2
Ever had bowel cancer screening	0.7	0.8	2.9	0.1	0.4	-0.2	0.9	1.7	0.9
Medication for cholesterol	0.7	1.0	2.0	-0.2	1.3	-0.5	-1.1	-0.9	-1.4
Illnesses of father: High blood pressure	0.7	0.9	3.6	-1.9	-0.3	-0.0	-0.8	-1.0	-0.1
Arm fat-free mass (left)	0.7	3.8	9.1	-1.4	-3.0	-2.5	1.8	-0.7	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	1.1	-0.5	-0.7	0.8	1.3	0.4
Arm predicted mass (left)	0.7	3.7	9.8	-1.5	-3.1	-2.3	1.7	-1.0	0.9
Worry (Nagel 2018)	0.6	1.3	5.4	0.4	2.3	0.3	0.6	1.4	0.1
Alzheimer’s Disease (including proxy)	0.6	0.8	2.1	1.5	-0.5	-1.1	-0.8	0.0	-0.9
Major Depression (MDD)	0.6	0.8	3.2	0.3	-0.7	-0.2	0.8	1.8	-0.3
Waist Hip Ratio (WHR)	0.6	2.6	7.4	-2.1	-0.2	-1.0	-0.7	-1.4	-2.7
Smoking Status	0.6	1.4	3.7	1.2	0.4	1.5	-0.3	0.7	-1.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	1.2	1.4	-0.7	0.7	0.5	-0.2
Hand grip strength (right)	0.6	1.5	4.0	-0.8	-1.6	-2.0	1.0	-0.4	0.8
Townsend deprivation index at recruitment	0.6	0.9	4.0	0.1	2.0	0.5	0.4	0.3	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	-0.4	-0.9	1.3	-0.8	0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	0.8	-1.2	0.9	0.5	0.8	-0.8
Had other major operations	0.6	0.8	2.9	-1.2	1.7	0.2	0.3	0.4	0.4
Qualifications: None of the above	0.6	1.2	3.7	-0.1	0.3	-0.1	-0.6	1.9	-1.8
Illnesses of siblings	0.6	0.9	1.9	1.4	1.1	-1.1	-0.5	0.1	-0.8
Neuroticism score	0.6	1.3	5.1	0.8	1.0	2.3	-0.5	0.5	-0.6
Father’s age at death	0.6	0.8	3.1	-0.6	-0.9	0.2	-1.8	0.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.9	1.4	1.0	1.2	0.6	1.2	-0.2
Number of live births	0.6	0.9	2.8	-0.5	-1.1	-1.7	0.8	0.1	-0.6
Noisy workplace	0.6	0.8	2.6	-0.8	0.8	1.6	-0.2	-0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	5.1	-0.1	0.0	-0.5	1.6	-0.8	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	0.5	-1.5	-0.9	-0.4	-0.8	-0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	-1.1	1.3	1.1	-0.1	0.2	-1.4
Age at first live birth	0.6	1.0	3.5	0.3	-1.9	0.1	-0.3	-1.5	-0.2
Medication: Ibuprofen	0.6	0.7	1.8	1.2	-1.3	0.1	0.6	0.7	0.6
Pulse rate, automated reading	0.6	1.8	4.8	0.1	1.0	2.2	-1.0	-1.1	-1.7
Alcohol intake frequency.	0.6	1.3	5.9	-0.3	0.7	-2.4	0.0	-1.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	-0.4	1.2	-0.5	1.1	1.0	0.7
Illnesses of siblings: Diabetes	0.6	0.7	2.1	-0.8	-1.2	0.2	-0.2	-1.4	-0.3
Loneliness, isolation	0.6	0.9	2.0	0.1	0.1	0.8	-1.4	-0.9	-1.3
Qualifications: nursing, teaching	0.6	1.0	1.9	0.2	1.3	1.0	1.1	-0.6	1.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.2	1.8	-0.5	0.2	0.3	1.4	0.0
Asthma (self-reported)	0.6	1.3	3.1	0.4	-0.5	-1.6	-0.2	-1.8	1.2
Illnesses of father: None of the above (group 1)	0.6	0.7	2.4	1.6	0.2	0.8	0.3	0.9	-0.6
High cholesterol (Self-reported)	0.6	1.0	2.6	-1.1	-1.0	0.3	0.9	1.6	-0.5
Medication: Atorvastatin	0.6	0.7	1.3	-1.1	-0.7	-0.9	0.9	0.2	1.0
Leg fat percentage (left)	0.6	2.0	5.4	1.8	1.7	0.7	0.0	2.3	0.4
Risk taking	0.6	0.9	2.8	0.2	0.4	-0.9	-1.7	1.0	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	1.9	-1.0	-1.4	1.2	0.0	0.8	-0.1
Ever depressed for a whole week	0.6	0.7	2.6	-0.4	1.6	-0.9	0.2	0.7	0.3
Cholesterol lowering medication	0.6	0.9	1.7	0.5	-1.3	1.3	0.4	1.1	0.3
Supplements: Calcium	0.6	0.7	1.9	1.2	-0.1	-0.1	-1.4	0.6	-0.6
Alcohol drinker status: Previous	0.6	0.7	2.7	-1.6	1.0	0.5	-0.2	-0.2	-0.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	0.7	-0.5	-1.3	-0.6	-0.3	-0.5
LDL Cholesterol	0.5	0.9	3.6	-0.5	-0.7	1.9	-0.3	-0.2	-0.9
Hand grip strength (left)	0.5	1.4	3.9	-0.5	-2.0	-0.7	1.3	1.3	0.6
Relative age of first facial hair	0.5	1.1	2.1	1.5	0.8	1.0	-0.9	-1.2	-0.7
Medication for hormone replacement therapy	0.5	0.5	1.0	-1.0	-0.8	0.3	-0.9	-0.6	0.7
Supplements: Zinc	0.5	0.5	1.4	1.2	0.7	-0.8	0.5	0.4	0.4
Trunk fat percentage	0.5	2.0	7.9	2.8	0.7	0.4	-0.0	1.1	1.4
Taking other prescription medications	0.5	0.8	2.8	0.6	0.4	0.5	1.7	-0.1	1.1
Medication: Levothyroxine sodium	0.5	0.9	2.1	-0.8	-1.4	0.7	0.9	-1.2	-0.5
Impedance of leg (left)	0.5	2.3	7.6	1.3	2.8	-0.3	0.5	1.9	0.5
Nervous feelings	0.5	0.9	2.0	0.4	1.4	1.1	0.3	1.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.8	0.5	0.2	-0.5	-0.5	-1.2	1.7
Medication: Paracetamol	0.5	0.9	3.2	1.0	0.6	1.8	0.2	0.9	0.1
Body fat percentage	0.5	2.2	7.2	2.7	1.2	0.7	-0.0	1.5	1.3
Leg fat percentage (right)	0.5	1.7	4.9	1.6	1.6	0.8	-0.0	2.2	0.1
Exposure to tobacco smoke outside home	0.5	0.6	2.4	0.8	1.6	-0.4	-0.1	-0.0	0.5
Comparative height size at age 10	0.5	2.9	7.0	-1.2	-1.3	-2.3	1.0	-2.6	1.1
Family relationship satisfaction	0.5	0.7	2.5	-0.4	0.1	1.6	1.1	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	1.3	0.2	-0.5	-1.2	0.3	-0.2
Knee pain experienced in last month	0.5	0.8	1.9	1.4	-0.6	0.3	0.9	1.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	-1.0	0.3	-1.2	-0.5	0.0	0.4
Wears glasses or contact lenses	0.5	0.5	1.3	-0.3	-0.1	0.8	0.7	-1.2	0.8
Age started oral contraceptive pill	0.5	0.6	1.9	1.1	-0.5	1.4	0.3	0.3	0.2
Commuting to job workplace: Cycle	0.5	0.6	2.0	1.4	-0.9	0.5	0.3	0.1	0.8
Heart disease (siblings)	0.5	0.6	1.4	0.5	1.2	1.0	-0.4	0.8	-0.6
Irritable Bowel Disease (IBD)	0.4	0.9	2.6	-0.7	0.6	-1.6	0.9	-0.2	1.2
Triglycerides	0.4	0.7	2.3	0.7	0.2	-1.5	0.1	0.5	1.1
Blood Eosinophil Count	0.4	3.3	9.9	-1.8	-2.6	-0.2	-0.1	-3.1	0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.7	0.7	0.7	0.9	0.5	0.4
Pack years adult smoking proportion	0.4	0.6	1.3	-1.1	-0.2	0.9	-0.1	-1.1	-0.4
Impedance of leg (right)	0.4	1.8	6.0	0.8	2.4	-0.4	0.8	1.8	0.4
Stomach or abdominal pain in last month	0.4	0.5	1.4	-0.3	-0.3	1.0	-0.4	1.2	-0.7
Financial difficulties in last 2 years	0.4	0.6	1.8	-0.3	-0.1	0.7	-1.0	0.1	-1.3
Heart attack	0.4	0.5	1.8	-0.7	0.6	-0.6	-0.1	-0.3	1.4
Weight	0.4	2.0	7.0	0.1	-2.6	-1.3	0.9	-0.8	1.2
Happiness	0.4	0.5	1.5	-0.1	-1.2	0.4	1.2	0.3	-0.2
Gout (self-reported)	0.4	0.6	1.3	-1.2	-0.9	-0.5	-0.4	-0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.3	0.7	0.5	0.1	1.1	-1.1
Had major operations	0.4	0.5	1.4	-0.6	-0.7	-0.5	1.2	0.7	0.0
Arm fat percentage (left)	0.4	1.4	5.2	2.3	0.8	1.1	-0.7	0.9	0.5
Guilty feelings	0.4	0.7	1.7	-0.3	0.7	1.3	-0.7	0.2	-1.0
Hearing aid user	0.4	0.4	1.9	-0.5	0.2	1.4	-0.5	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.7	0.3	-0.7	-0.0	-1.3	0.4	0.1
Depression (Nagel 2018)	0.3	0.5	1.0	0.8	0.4	0.8	-0.6	-0.3	-1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.3	-0.8	-0.1	1.0	-0.2	1.0
Fasting Glucose	0.3	0.4	1.1	-0.6	0.2	-1.1	0.5	0.7	-0.3
Hearing difficulty/problems: Yes	0.3	0.4	1.8	-1.4	0.2	-0.2	-0.1	-0.2	0.6
Medication: Metformin	0.3	0.5	0.9	-1.0	-0.5	0.6	0.5	-0.1	1.0
Diabetes (father)	0.3	0.3	0.8	0.9	-0.4	-0.2	0.5	-0.4	0.9
Relative age voice broke	0.3	0.5	0.9	0.7	-0.8	1.0	0.8	-0.0	0.6
Supplements: Glucosamine	0.3	0.4	1.3	0.8	-1.1	-0.7	-0.0	0.0	-0.4
Trunk fat mass	0.3	1.2	4.3	2.1	-0.5	-0.4	0.5	0.5	1.5
Hearing difficulty/problems with background noise	0.3	0.5	2.4	-0.1	-1.6	0.3	-0.1	-0.2	0.5
Impedance of arm (right)	0.3	1.4	4.3	2.1	1.6	-0.1	0.3	-0.5	1.2
Arm fat percentage (right)	0.3	1.3	4.9	2.2	1.0	0.4	-0.5	0.9	0.6
Pulse rate	0.3	0.4	1.4	0.2	1.2	-0.4	-0.8	-0.5	-0.4
Impedance of arm (left)	0.3	1.2	3.6	1.9	1.4	0.6	-0.2	-0.4	1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	-0.5	-0.1	0.5	-0.6	-0.3	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	-0.1	-1.1	0.9	-0.4	-0.0	-0.2
Medication: Seretide 50 evohaler	0.3	0.4	0.8	0.6	0.9	0.3	0.5	-0.7	0.0
Whole body fat mass	0.3	1.2	3.6	1.9	-0.1	-0.2	0.7	0.8	1.5
Chest pain or discomfort	0.3	0.4	1.5	-1.2	-0.9	-0.2	-0.0	0.4	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.4	0.6	0.6	0.5	0.9	-0.2
Medication: Paracetamol	0.3	0.5	1.5	1.2	0.4	0.8	-0.5	0.5	0.2
Irritability	0.3	0.5	1.3	1.0	-0.9	1.1	0.2	-0.1	-0.2
Unable to work because of sickness or disability	0.3	0.4	1.2	0.5	0.1	-0.4	0.1	0.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.9	0.4	-0.4	0.0	-0.4	1.2
Impedance of whole body	0.3	1.5	3.8	1.9	1.9	-0.0	0.5	0.5	1.2
Leg fat mass (left)	0.3	1.0	2.7	1.6	0.1	-0.1	0.8	1.4	0.8
Mean Putamen Volume	0.2	0.2	1.0	-1.0	0.4	-0.1	-0.2	-0.1	-0.0
Lupus	0.2	0.4	0.9	-0.9	-0.5	-1.0	0.1	0.1	-0.5
Rheumatoid Arthritis	0.2	0.3	1.0	1.0	-0.2	-1.0	0.1	-0.2	0.0
Ulcerative Colitis	0.2	0.2	0.3	0.6	0.4	-0.1	-0.5	0.6	-0.5
Blood White Count	0.2	1.5	4.4	2.1	-1.5	-0.5	-0.5	-1.4	0.1
BMI	0.2	1.0	2.9	1.7	-0.2	-0.2	-0.1	1.7	-0.3
Lung FVC	0.2	1.3	4.4	-1.1	2.1	-0.6	-0.2	1.2	0.0
Diabetes (self-reported)	0.2	0.3	0.7	0.4	0.4	0.0	-0.6	0.8	-0.7
Hip circumference	0.2	0.9	2.7	0.8	-1.6	-0.4	0.4	-0.0	1.4
Time employed in main current job	0.2	0.2	0.5	-0.4	-0.7	0.2	0.2	0.2	0.6
Leg fat mass (right)	0.2	0.8	2.1	1.4	0.2	-0.1	0.6	1.4	0.5
Leg pain on walking	0.2	0.3	1.3	-0.4	-0.3	1.1	-0.0	0.4	-0.3
Smoking status: Previous	0.2	0.2	0.8	-0.3	-0.4	0.9	-0.3	0.2	-0.5
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.6	0.6	-0.4	0.8	0.2	0.3
Diabetes diagnosed by doctor	0.2	0.3	1.1	0.4	-0.3	0.4	0.6	1.0	-0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.5	-0.3	-1.2	-0.0	-0.2	-0.8	-0.3
Pack years of smoking	0.2	0.3	0.8	-0.8	-0.1	0.7	0.2	-0.9	-0.1
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.3	0.5	0.4	0.2	0.6	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.6	0.2	0.1	0.2	0.0	0.1	-0.8
Chronotype (morning person)	0.1	0.3	0.7	0.1	-0.9	-0.5	0.5	-0.6	-0.2
Hair Pigment	0.1	2.5	5.2	0.1	0.2	-1.6	2.2	2.3	1.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	-0.6	-0.1	0.2	0.1	0.4	-0.6
Body mass index (BMI)	0.1	0.4	1.2	1.1	-0.3	0.3	-0.5	1.0	0.0
Waist circumference	0.1	0.3	0.8	0.9	-0.7	-0.7	0.0	0.4	0.2
Pain all over the body in last month	0.1	0.1	0.4	-0.4	-0.4	0.0	-0.0	0.1	0.7
Arm fat mass (right)	0.1	0.5	2.0	1.4	-0.5	-0.3	0.2	0.4	0.8
Pulse wave reflection index	0.1	0.1	0.6	-0.1	0.1	-0.2	0.2	0.8	0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.6	-0.1	-0.6	0.4	0.1	0.4
Medication: Allopurinol	0.1	0.1	0.6	-0.3	-0.8	-0.2	-0.1	-0.2	-0.1
Medication: Gliclazide	0.1	0.2	0.6	0.1	-0.3	-0.2	0.8	-0.3	0.5
Arm fat mass (left)	0.1	0.4	1.6	1.3	-0.6	0.1	0.0	0.4	0.8
Tanning	0.0	0.3	1.2	0.7	0.3	0.3	0.1	-1.1	-0.0

Hub : Genes

ARHGEF3

Models

Trait associations