TWAS hub - PDE10A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.2100	0.0630	0.0027	0.123	NA	0.152	NA	0.121	1.2e-09	NA	1.1e-11	NA	1.7e-09
2	TCGA	Breast Invasive Carcinoma	0.0276	0.0116	0.0060	0.006	0.01	0.009	NA	0.004	2.0e-02	0.0026	3.9e-03	NA	3.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hypothyroidism (self reported)	7.0	16.1	28.5	5.3	-1.9
Commuting to job workplace: Public transport	5.7	6.8	12.9	3.6	0.9
Rheumatoid Arthritis	4.5	6.1	12.3	0.1	3.5
Hypothyroidism/myxoedema (self-reported)	4.5	8.8	15.4	3.9	-1.5
Ever had bowel cancer screening	4.3	5.1	7.0	-1.8	2.6
Ever depressed for a whole week	4.1	5.0	9.9	0.4	3.1
Friendships satisfaction	3.9	4.8	5.6	2.0	-2.4
Medication: Co-codamol	3.8	4.4	7.1	-2.7	1.3
Illnesses of father: None of the above (group 1)	3.8	4.7	5.7	2.4	-1.9
Medication: Levothyroxine sodium	3.7	6.2	9.1	3.0	-1.8
Medication: Ramipril	3.7	4.8	9.3	0.5	3.1
Ever used hormone-replacement therapy (HRT)	3.6	4.6	7.8	-1.2	2.8
Townsend deprivation index at recruitment	3.6	5.1	6.2	2.5	2.0
Age started oral contraceptive pill	3.4	4.3	5.8	-2.4	1.7
Noisy workplace	3.3	4.0	7.5	-0.8	2.7
Wheeze or whistling in the chest in last year	3.2	5.7	7.6	2.0	2.8
Long-standing illness, disability or infirmity	3.1	4.8	9.5	-0.0	3.1
Osteoporosis (self-reported)	3.1	3.9	7.6	-0.4	2.8
Serious illness, injury or assault to yourself	2.9	3.5	6.7	-2.6	0.5
High blood pressure (siblings)	2.9	4.2	6.8	-2.6	1.3
HbA1C	2.8	3.1	4.9	1.1	-2.2
Medication for hormone replacement therapy	2.8	3.2	6.3	0.2	2.5
Stomach or abdominal pain in last month	2.8	3.5	5.0	1.4	2.2
Gout (self-reported)	2.8	3.8	7.0	-2.6	-0.8
Emphysema/chronic bronchitis	2.7	3.0	3.4	1.6	1.9
Family relationship satisfaction	2.7	3.4	6.2	2.5	-0.7
Ulcerative Colitis (UC)	2.6	4.8	9.2	-3.0	0.7
Crohns Disease (2012)	2.6	4.2	7.7	-2.8	0.8
Ever had hysterectomy (womb removed)	2.6	2.9	3.4	-1.5	1.9
Illnesses of siblings	2.6	3.6	4.9	1.5	-2.2
Eye problems/disorders: None of the above	2.6	3.0	5.5	0.6	2.4
Mouth/teeth dental problems: Dentures	2.5	4.2	6.0	-1.6	2.4
Medication: Ibuprofen	2.4	2.9	4.8	-2.2	-1.0
Ulcerative Colitis	2.3	3.4	6.8	-2.6	0.3
Maternal smoking around birth	2.3	3.3	6.5	0.2	2.6
Pulse wave Arterial Stiffness index	2.3	2.7	4.2	-2.1	1.1
Pulse wave peak to peak time	2.2	2.5	3.6	1.9	-1.2
Average weekly champagne plus white wine intake	2.2	3.0	5.9	-0.2	-2.4
Diabetes (father)	2.1	2.6	5.2	0.3	2.3
Qualifications: College or University degree	2.1	6.6	11.8	-1.2	-3.4
Illnesses of father: High blood pressure	2.1	2.6	5.0	-2.2	-0.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	2.6	-1.6	1.4
Past tobacco smoking	2.0	3.7	4.1	-1.8	-2.0
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.8	-0.4	2.2
Systolic blood pressure, automated reading	1.9	5.6	6.3	-2.5	2.2
Qualifications: A levels/AS levels or equivalent	1.9	4.3	8.2	0.6	-2.9
Lung cancer (father)	1.9	2.2	3.5	-1.9	0.9
Medication: Bendroflumethiazide	1.9	3.0	4.5	-1.2	2.1
Irritable Bowel Disease (IBD)	1.8	4.4	8.5	-2.9	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	2.8	1.7	1.3
Ever taken oral contraceptive pill	1.8	2.0	3.3	-1.8	0.8
Supplements: Glucosamine	1.7	2.2	4.3	-2.1	-0.4
Fluid intelligence score	1.7	3.6	3.7	-1.9	-1.9
Medication: Allopurinol	1.7	2.3	4.5	-2.1	0.3
Overall health rating	1.7	3.7	6.8	-0.8	2.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	6.0	-1.1	-2.4
Medication: Gliclazide	1.7	1.9	3.6	0.5	1.9
Verbal and Numeric Reasoning (VNR)	1.6	3.7	5.1	-2.3	-1.5
Coronary Artery Disease (CAD)	1.6	1.9	3.7	-0.3	1.9
Taking other prescription medications	1.6	2.5	5.0	0.1	2.2
Medication: Lansoprazole	1.6	1.8	3.6	-0.3	1.9
Shortness of breath walking on level ground	1.6	1.9	3.2	-0.7	1.8
Medication: Atenolol	1.5	1.9	3.0	0.9	1.7
Pulse wave reflection index	1.5	1.9	2.1	-1.4	1.3
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.6	-0.0	-1.9
Smoking status: Previous	1.5	2.2	3.3	1.8	1.1
Loneliness, isolation	1.5	2.0	2.6	1.6	1.2
Vascular/heart problems diagnosed by doctor	1.5	4.0	7.5	0.6	-2.7
Triglycerides	1.4	2.3	4.5	2.1	0.3
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.8	2.0	0.2
Vitamin and mineral supplements	1.4	1.9	3.6	0.3	1.9
Alcohol intake versus 10 years previously	1.4	2.1	2.3	-1.4	1.5
Length of working week for main job	1.4	1.5	2.2	-0.9	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.6	1.9	0.8
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.5	1.9	-0.4
Commuting to job workplace: Walk	1.4	1.5	1.8	1.3	-1.1
Depressed Affect (Nagel 2018)	1.3	2.8	4.1	2.0	1.2
Had other major operations	1.3	1.6	2.0	-1.4	1.1
Medication: Amlodipine	1.3	1.8	3.4	-1.9	-0.4
Medication: Blood pressure	1.3	2.3	4.3	-0.5	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.8	2.2	-0.9
Had menopause	1.2	1.5	1.9	-1.1	1.4
Qualifications: None of the above	1.2	2.5	4.9	0.2	2.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.8	1.7	-0.2
Miserableness	1.2	2.1	3.8	1.9	0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	-1.7	0.2
Ever smoked	1.2	2.2	2.8	1.2	1.7
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.0	0.5	1.7
Intelligence (Savage-Jansen 2018)	1.1	3.5	4.2	-2.0	-1.7
Alzheimer’s Disease (in father)	1.1	1.2	1.9	-1.4	-0.7
Neuroticism (2016)	1.1	1.6	3.1	-0.1	-1.8
High blood pressure	1.1	3.1	5.7	-0.8	2.4
Number of incorrect matches in round	1.1	1.9	2.9	1.7	0.9
Heart attack	1.1	1.4	2.6	0.4	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	3.7	0.1	1.9
Supplements: Vitamin C	1.1	1.3	2.1	0.7	-1.4
Myopia	1.1	1.5	2.4	-1.5	0.8
Heart disease (siblings)	1.1	1.4	2.7	0.1	1.6
Smoking Status	1.0	2.3	2.6	1.6	1.4
Average weekly fortified wine intake	1.0	1.1	1.4	-1.2	-0.9
Mouth/teeth dental problems	1.0	1.6	2.9	-0.4	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.3	-1.5	-0.5
Headache pain in last month	1.0	1.7	2.4	1.0	-1.6
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.4	-1.0	1.2
Migraine (self-reported)	1.0	1.3	1.4	1.2	-1.0
Age at last live birth	1.0	1.5	2.3	-1.5	-0.8
Medication: Aspirin	1.0	1.4	2.4	0.6	1.5
Mood swings	1.0	1.8	2.7	1.7	-0.9
Medication: Aspirin	1.0	1.3	2.3	0.5	1.5
Number of treatments/medications taken	0.9	1.6	1.7	-1.3	1.2
Hearing difficulty/problems: Yes	0.9	1.4	2.4	-0.6	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.9	-2.0	-0.3
Happiness	0.9	1.1	2.0	1.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.8	0.5	-1.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	1.9	0.7	1.4
Comparative body size at age 10	0.9	2.4	3.4	1.8	-1.2
Osteoarthritis (self-reported)	0.9	1.1	2.3	-0.0	1.5
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	-0.2	-1.4
Bipolar Disorder (2011)	0.8	0.8	1.6	-1.3	0.1
LDL Cholesterol	0.8	1.3	2.4	-0.4	1.5
Systolic Blood Pressure	0.8	4.2	4.8	-1.9	2.2
Multivitamins +/- minerals	0.8	1.0	1.9	0.2	-1.4
Time employed in main current job	0.8	0.9	1.1	-0.8	1.1
Number of live births	0.8	1.1	2.2	-1.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	2.9	1.5	-1.7
Depression (self-reported)	0.8	1.0	1.2	0.9	-1.1
Leg fat percentage (right)	0.8	3.0	5.5	-0.8	2.3
Angina (self-reported)	0.8	1.1	1.8	1.3	0.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.7	-1.3	0.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.7	0.5	-1.3
Diabetes diagnosed by doctor	0.8	1.4	1.5	-1.2	1.1
Number of self-reported non-cancer illnesses	0.8	1.4	2.4	0.6	1.6
Medication: Blood pressure	0.8	1.5	2.7	-1.6	0.5
Crohns Disease (2017)	0.7	1.5	2.9	-1.7	0.3
Mean Putamen Volume	0.7	0.8	1.6	-1.2	-0.2
High blood pressure (mother)	0.7	1.0	1.7	0.6	-1.3
Medication: Cholesterol lowering	0.7	1.1	1.3	1.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	2.9	1.3	-1.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.5	-0.8	-1.2
Exposure to tobacco smoke outside home	0.7	1.0	1.9	0.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.0	0.8	-1.0
Heart disease (mother)	0.7	0.9	1.7	0.3	-1.3
Chest pain or discomfort	0.7	1.1	1.5	1.2	0.8
Eye problems/disorders: Cataract	0.7	0.8	0.9	-0.9	-0.9
Fractured/broken bones in last 5 years	0.7	0.9	1.0	1.0	0.9
Diastolic blood pressure, automated reading	0.7	2.2	2.9	-1.3	1.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	1.3	0.2
Schizophrenia (2018)	0.6	1.2	1.6	0.8	1.3
Ovarian Cancer	0.6	0.8	1.5	0.2	-1.2
Fasting Glucose	0.6	0.7	1.4	1.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.7	-0.8	-0.9
Medication: Metformin	0.6	0.9	1.4	0.6	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	1.7	0.2	1.3
Age when periods started (menarche)	0.6	1.4	2.0	0.9	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-0.3	-1.1
Forced vital capacity (FVC), Best measure	0.6	2.1	3.2	1.0	-1.8
Worry too long after embarrassment	0.6	1.0	1.1	-1.1	0.9
Medication for pain relief, constipation, heartburn	0.6	1.0	1.4	-0.8	-1.2
Pulse rate, automated reading	0.6	2.0	3.3	-1.8	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.0	1.0	-0.6
Hypertension (Self-reported)	0.6	1.7	3.2	-0.5	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	-1.1	0.5
Hearing aid user	0.6	0.7	1.4	-1.2	-0.1
Financial situation satisfaction	0.6	0.8	1.5	0.1	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	0.6	1.0
Breast Cancer	0.5	1.1	2.0	1.4	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.2	-1.1	-0.4
Blood Red Count	0.5	4.8	8.0	-2.8	1.3
Angina	0.5	0.7	0.9	0.9	0.8
Supplements: Zinc	0.5	0.6	1.2	0.1	-1.1
Fed-up feelings	0.5	0.9	1.7	0.2	1.3
Qualifications: CSEs or equivalent	0.5	0.6	1.0	1.0	0.6
Hayfever, allergic rhinitis or eczema	0.5	1.2	1.4	1.0	-1.2
Hair/balding pattern: Pattern 2	0.5	0.6	0.7	0.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	-1.5	0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	0.4	1.0
Allergy	0.5	1.1	2.0	-1.4	0.6
Diabetes (self-reported)	0.5	0.8	1.4	-0.3	1.2
Blood clot in the leg (DVT)	0.5	0.7	0.8	0.9	0.8
Had major operations	0.5	0.6	0.6	-0.8	-0.7
Knee pain experienced in last month	0.5	0.7	1.5	-1.2	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.0	-0.4	1.0
Average weekly red wine intake	0.5	0.8	1.3	1.1	-0.6
High cholesterol (Self-reported)	0.5	0.9	1.1	0.8	-1.1
Medication: Lisinopril	0.5	0.7	0.8	0.8	0.9
Leg fat percentage (left)	0.5	1.8	3.5	-0.2	1.9
Number of operations (self-reported)	0.5	0.7	1.1	-1.0	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	1.4	0.7	1.2
Major Depression (MDD)	0.4	0.4	0.5	0.7	-0.6
Body Mass Index (BMI) (2010)	0.4	0.5	0.7	0.6	0.8
Blood White Count	0.4	2.7	4.7	-0.8	2.2
Chronotype (morning person)	0.4	0.9	1.7	0.1	1.3
Diabetes (mother)	0.4	0.5	0.6	-0.8	-0.6
Severe depression (siblings)	0.4	0.5	0.6	0.5	-0.8
Impedance of leg (right)	0.4	2.1	2.4	-1.6	1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	0.6	0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-1.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.1	1.1	-0.5
Forced vital capacity (FVC)	0.4	1.7	2.8	0.8	-1.7
Number of children fathered	0.4	0.5	0.6	-0.6	-0.7
Medication: Omeprazole	0.4	0.5	0.9	1.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.7	-0.6	0.8
Back pain experienced in last month	0.4	0.6	1.0	1.0	-0.4
Breast cancer (self-reported)	0.4	0.5	0.8	-0.9	0.4
Guilty feelings	0.4	0.6	1.0	-1.0	-0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	-0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	0.9	0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.3	0.2	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.9	0.2
HDL Cholesterol	0.3	0.4	0.7	0.4	0.9
Lupus	0.3	0.5	0.7	-0.6	0.8
Height	0.3	6.1	8.5	-2.9	-1.9
Waist Hip Ratio (WHR)	0.3	1.6	1.8	-1.1	1.4
Allergy or Eczema	0.3	0.8	1.1	0.7	-1.1
Cardiovascular Disease	0.3	0.9	1.8	0.3	1.3
Lung FEV1/FVC ratio	0.3	1.7	2.9	1.7	0.6
Tanning	0.3	3.5	6.7	2.6	0.6
Trunk fat percentage	0.3	1.0	1.7	-0.6	1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	-0.3	-0.7
Pain all over the body in last month	0.3	0.4	0.6	-0.8	-0.3
Neuroticism score	0.3	0.5	0.8	0.9	-0.5
Standing height	0.3	3.1	3.8	-1.6	-1.9
Breastfed as a baby	0.3	0.4	0.6	-0.8	0.5
Peak expiratory flow (PEF)	0.3	0.6	1.0	1.0	-0.5
Body fat percentage	0.3	1.3	2.4	-0.4	1.5
Age at first live birth	0.3	0.4	0.9	-0.9	-0.1
Mean time to correctly identify matches	0.3	0.5	1.0	1.0	0.0
Leg fat mass (right)	0.3	1.2	2.1	-0.6	1.4
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.6	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	-0.3	0.8
Unable to work because of sickness or disability	0.3	0.3	0.7	-0.8	0.0
Cholesterol lowering medication	0.3	0.4	0.7	0.2	-0.8
Depression (Nagel 2018)	0.2	0.4	0.7	-0.2	0.8
Reaction Time	0.2	0.5	0.5	0.7	-0.7
Blood Platelet Count	0.2	2.8	5.0	2.2	0.8
Heel T-Score	0.2	1.6	3.1	-1.8	-0.0
BMI	0.2	1.0	1.7	0.5	1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.0	0.8
Hand grip strength (left)	0.2	0.6	0.9	1.0	-0.5
Hand grip strength (right)	0.2	0.4	0.4	0.7	-0.7
Body mass index (BMI)	0.2	0.9	1.7	0.3	1.3
Trunk fat mass	0.2	0.8	1.3	-0.6	1.1
Alcohol usually taken with meals	0.2	0.3	0.4	0.6	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.3	0.6	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.3	-0.5	-0.5
Medication: Simvastatin	0.2	0.3	0.6	0.8	-0.1
Arm fat percentage (right)	0.2	0.7	1.3	-0.1	1.2
Hip circumference	0.2	0.9	1.3	-1.1	-0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.2	0.8
Loud music exposure frequency	0.2	0.2	0.3	0.0	-0.6
Birth weight	0.2	0.3	0.6	0.8	0.2
Number of full brothers	0.2	0.2	0.3	-0.4	0.5
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.8	0.3
Suffer from ‘nerves’	0.2	0.3	0.6	0.1	0.8
Leg pain on walking	0.2	0.3	0.5	0.1	0.7
Arm fat percentage (left)	0.2	0.8	1.6	-0.2	1.2
Medication for cholesterol	0.2	0.3	0.3	0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.1	0.7
Wears glasses or contact lenses	0.2	0.2	0.4	0.6	-0.2
Mother’s age at death	0.2	0.2	0.3	0.4	-0.5
Alcohol drinker status: Never	0.2	0.3	0.4	0.7	0.3
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.7	0.3
Irritability	0.2	0.3	0.5	0.7	-0.4
Risk taking	0.2	0.3	0.5	-0.2	-0.7
Supplements: Calcium	0.2	0.2	0.3	-0.5	-0.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.3	-0.7
Alcohol drinker status: Previous	0.2	0.3	0.4	0.7	-0.2
Leg fat mass (left)	0.2	0.7	1.4	-0.3	1.2
Worry (Nagel 2018)	0.1	0.3	0.5	-0.7	-0.3
Schizophrenia (2014)	0.1	0.2	0.3	-0.3	0.5
Lung FVC	0.1	0.7	1.3	1.1	-0.4
Average weekly spirits intake	0.1	0.2	0.3	0.0	0.6
Relative age of first facial hair	0.1	0.1	0.3	0.1	0.5
Leg fat-free mass (left)	0.1	0.4	0.6	-0.4	-0.8
Relative age voice broke	0.1	0.2	0.4	0.6	-0.2
Impedance of leg (left)	0.1	0.6	0.8	-0.9	0.7
Leg predicted mass (left)	0.1	0.4	0.6	-0.4	-0.8
Waist circumference	0.1	0.2	0.2	-0.5	0.5
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.2	0.5
Impedance of arm (right)	0.1	0.3	0.5	-0.7	-0.3
Trunk fat-free mass	0.1	0.6	0.8	-0.9	-0.6
Father’s age at death	0.1	0.1	0.2	-0.2	-0.4
Worrier / anxious feelings	0.1	0.3	0.3	-0.5	-0.5
Prospective memory result	0.1	0.1	0.1	-0.3	0.3
Impedance of arm (left)	0.1	0.3	0.6	-0.8	-0.1
Arm fat mass (right)	0.1	0.3	0.6	-0.1	0.8
Trunk predicted mass	0.1	0.7	1.0	-1.0	-0.6
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.2	-0.3
Tense / ‘highly strung’	0.1	0.1	0.2	0.2	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.0	-0.8
Birth weight of first child	0.1	0.3	0.3	-0.6	0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.1	0.6
Arm fat-free mass (right)	0.1	0.4	0.8	-0.9	-0.2
Health satisfaction	0.1	0.2	0.3	-0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.0	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.0
Whole body fat mass	0.1	0.6	1.2	-0.1	1.1
Arm predicted mass (right)	0.1	0.6	0.9	-1.0	-0.6
Alcohol intake frequency.	0.1	0.1	0.3	0.0	0.5
Comparative height size at age 10	0.1	0.7	0.7	-0.8	-0.9
Number of full sisters	0.1	0.1	0.2	0.1	-0.5
Whole body fat-free mass	0.1	0.6	0.6	-0.8	-0.8
Leg fat-free mass (right)	0.1	0.8	1.5	-0.1	-1.2
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.4	-0.2
Asthma (self-reported)	0.1	0.1	0.2	0.3	0.4
Smoking status: Current	0.1	0.1	0.2	0.1	0.5
Whole body water mass	0.1	0.6	0.7	-0.7	-0.9
Leg predicted mass (right)	0.1	0.8	1.6	-0.1	-1.3
Arm fat mass (left)	0.1	0.3	0.6	-0.2	0.8
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.2	-0.6
Medication: Paracetamol	0.1	0.1	0.2	-0.4	0.1
Medication: Atorvastatin	0.1	0.1	0.1	0.2	0.4
Basal metabolic rate	0.1	0.4	0.4	-0.6	-0.6
Pain experienced in last month	0.1	0.1	0.2	0.5	-0.2
Impedance of whole body	0.1	0.6	1.1	-1.1	0.3
Arm predicted mass (left)	0.1	0.5	0.7	-0.8	-0.5
Bipolar Disorder (2018)	0.0	0.0	0.1	0.1	0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.0	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.0	-0.0	-0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.1	-0.2
Blood Eosinophil Count	0.0	0.4	0.7	0.8	0.3
Respiratory disease	0.0	0.1	0.1	0.1	0.3
Neuroticism	0.0	0.1	0.2	0.4	-0.2
Hair Pigment	0.0	0.7	1.5	-1.2	-0.0
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	-0.1
Pack years adult smoking proportion	0.0	0.0	0.0	-0.2	0.0
Current tobacco smoking	0.0	0.1	0.1	-0.3	0.3
Sitting height	0.0	0.2	0.2	0.4	-0.4
Nervous feelings	0.0	0.0	0.0	0.1	-0.0
Weight	0.0	0.2	0.3	-0.5	0.2
Falls in the last year	0.0	0.0	0.0	0.2	-0.2
Pulse rate	0.0	0.1	0.1	-0.2	-0.3
Asthma	0.0	0.1	0.1	0.3	0.3
Illnesses of mother	0.0	0.0	0.0	0.2	-0.1
Glaucoma (self-reported)	0.0	0.0	0.0	0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	0.2	0.1
Mineral and other dietary supplements	0.0	0.0	0.0	0.1	0.2
Arm fat-free mass (left)	0.0	0.1	0.2	-0.4	-0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	-0.0	-0.1
Pack years of smoking	0.0	0.0	0.1	-0.3	0.2

Hub : Genes

PDE10A

Models

Trait associations