Hub : Genes

FAM208B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.230 0.080 0.0065 0.023 NA -0.005 NA 0.06 0.0310 NA 0.6800 NA 0.0012
2 GTEx Skin Sun Exposed Lower leg 0.101 0.038 0.0062 0.031 NA 0.020 NA 0.03 0.0012 NA 0.0081 NA 0.0014

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.2 2.4 -1.6 0.1
Bipolar Disorder or Schizophrenia 0.6 1.4 1.9 -1.4 -0.9
Depressed Affect (Nagel 2018) 0.5 1.0 1.9 -0.1 1.4
Depression (Nagel 2018) 0.2 0.4 0.7 0.9 -0.1
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 0.3 1.2
Neuroticism (Nagel 2018) 0.1 0.2 0.5 -0.1 0.7
Schizophrenia (2018) 0.4 0.9 1.4 -0.6 -1.2
Schizophrenia vs Biploar Disorder 1.2 1.6 3.2 1.8 0.3
Worry (Nagel 2018) 0.0 0.1 0.1 -0.4 0.1
Alzheimer’s Disease (in mother) 2.2 2.6 4.3 1.0 -2.1
Alzheimer’s Disease (in father) 0.5 0.6 1.1 -0.3 -1.0
Alzheimer’s Disease (including proxy) 1.1 1.5 2.9 0.4 -1.7
Crohns Disease (2017) 0.1 0.3 0.3 -0.5 0.5
Irritable Bowel Disease (IBD) 0.3 0.8 0.9 0.8 -1.0
Ulcerative Colitis (UC) 1.9 3.6 4.8 1.6 -2.2
Major Depression (MDD) 0.8 1.0 1.5 1.2 -0.7
Reaction Time 0.3 0.6 0.7 -0.7 -0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.9 -0.4 0.9
Breast Cancer 1.3 3.1 3.2 1.8 -1.8
Ovarian Cancer 0.5 0.7 1.3 -1.2 -0.1
Prostate Cancer 3.7 5.2 10.1 -3.2 -0.5
Age at First Birth 0.6 0.9 1.4 1.2 0.6
Bipolar Disorder (2011) 2.6 2.5 4.8 -2.2 -0.5
Body Mass Index (BMI) (2010) 0.8 1.1 1.3 -1.1 0.9
Coronary Artery Disease (CAD) 0.3 0.3 0.7 -0.1 -0.8
Crohns Disease (2012) 0.1 0.2 0.2 -0.4 -0.4
Mean Putamen Volume 2.4 2.8 3.6 1.4 1.9
Fasting Glucose 1.0 1.2 1.4 -1.2 -1.0
HbA1C 0.6 0.7 1.3 -0.2 1.1
HDL Cholesterol 0.5 0.8 1.5 -0.1 -1.2
LDL Cholesterol 0.3 0.5 1.1 -1.0 -0.0
Lupus 0.8 1.2 2.2 0.5 -1.5
Neuroticism (2016) 0.2 0.3 0.4 -0.3 0.6
Primary Biliary Cirrhosis 0.7 1.0 2.1 -1.4 0.1
Rheumatoid Arthritis 10.0 13.8 25.5 1.4 -5.0
Schizophrenia (2014) 0.1 0.3 0.5 0.1 -0.7
Triglycerides 0.4 0.6 0.8 -0.6 0.9
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.3 -0.4
Ulcerative Colitis 1.7 2.4 2.6 1.5 -1.6
Blood Eosinophil Count 4.8 37.1 43.6 -5.5 -6.6
Blood Platelet Count 0.0 0.2 0.4 0.2 -0.6
Blood Red Count 0.0 0.1 0.2 -0.2 0.4
Blood White Count 0.2 1.2 2.4 -0.1 -1.5
Heel T-Score 0.0 0.1 0.1 0.1 -0.4
BMI 0.7 3.9 7.5 0.6 -2.7
Height 0.0 0.7 1.4 0.2 1.2
Waist Hip Ratio (WHR) 0.6 2.5 4.6 0.6 -2.1
Systolic Blood Pressure 0.3 1.4 2.3 1.5 0.6
Smoking Status 0.1 0.1 0.2 0.1 -0.5
Allergy or Eczema 2.9 7.6 13.8 -3.7 -1.2
Cardiovascular Disease 0.3 0.9 1.7 1.3 0.2
Hypothyroidism (self reported) 17.4 40.1 78.5 1.3 -8.9
Respiratory disease 5.8 12.8 19.2 -2.5 -4.4
Type 2 Diabetes (T2D) (2018) 1.8 3.4 5.9 1.0 -2.4
Lung FEV1/FVC ratio 0.4 2.1 2.7 1.2 1.6
Lung FVC 0.5 2.3 3.7 1.9 1.0
Neuroticism 0.5 1.3 2.4 -0.3 1.6
Chronotype (morning person) 0.7 1.6 2.8 -0.6 -1.7
Hair Pigment 0.0 1.3 2.7 0.0 -1.6
Tanning 0.0 0.2 0.3 0.5 -0.4
Hand grip strength (left) 1.1 3.0 6.0 2.4 -0.2
Number of treatments/medications taken 5.4 9.7 18.8 0.7 -4.3
Average weekly spirits intake 0.1 0.1 0.2 0.4 0.3
Sensitivity / hurt feelings 0.1 0.1 0.1 0.3 0.4
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.1 -0.3 0.2
Hearing difficulty/problems: Yes 0.6 0.9 1.8 0.0 1.4
Relative age of first facial hair 0.6 1.2 2.5 -0.1 1.6
Other serious medical condition/disability diagnosed by doctor 3.2 4.1 8.2 0.2 -2.9
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.6 0.8 -0.4
Ever had hysterectomy (womb removed) 1.8 2.0 2.5 1.3 -1.6
Systolic blood pressure, automated reading 0.1 0.2 0.3 0.5 0.4
Eye problems/disorders: Diabetes related eye disease 3.0 3.3 4.4 2.1 -1.5
Angina 0.5 0.6 0.8 0.9 0.6
Medication for hormone replacement therapy 0.3 0.3 0.4 0.6 -0.6
Vitamin and mineral supplements 0.7 1.0 1.7 -1.3 -0.5
Supplements: Zinc 0.0 0.0 0.0 0.2 -0.1
Medication: Co-codamol 0.2 0.3 0.4 -0.6 -0.3
Medication: Metformin 2.9 4.1 5.5 1.6 -2.4
Diabetes (father) 0.7 0.9 1.2 1.1 -0.8
Diabetes (mother) 0.8 1.1 2.1 -1.4 -0.2
Severe depression (siblings) 0.5 0.5 0.9 -1.0 -0.4
Pack years adult smoking proportion 0.8 1.2 2.3 1.5 0.3
Impedance of leg (right) 0.3 1.3 2.4 -0.4 1.5
Leg fat-free mass (left) 0.1 0.3 0.6 0.1 -0.8
Trunk fat percentage 0.4 1.4 2.8 -0.1 -1.7
Hand grip strength (right) 0.8 2.2 3.5 1.9 1.0
Townsend deprivation index at recruitment 1.0 1.4 2.4 1.5 0.7
Current tobacco smoking 0.7 1.2 1.9 0.7 -1.4
Average weekly fortified wine intake 0.6 0.7 1.4 -1.2 0.1
Maternal smoking around birth 0.6 0.9 1.5 -1.2 -0.6
Fed-up feelings 0.1 0.2 0.3 0.1 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.4 1.2 0.2
Relative age voice broke 0.0 0.1 0.1 0.1 0.4
Taking other prescription medications 11.5 17.7 35.4 0.3 -6.0
Age when periods started (menarche) 0.6 1.3 1.5 1.2 1.1
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 3.3 0.2 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.6 0.5
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 1.8 0.7 1.4
Qualifications: CSEs or equivalent 0.1 0.1 0.2 -0.4 0.1
Serious illness, injury or assault to yourself 0.6 0.8 0.9 -0.8 -1.0
High blood pressure 0.1 0.3 0.4 0.6 -0.5
Hayfever, allergic rhinitis or eczema 4.0 8.7 15.9 -4.0 -1.2
Multivitamins +/- minerals 0.7 0.9 1.6 0.4 1.3
Stomach or abdominal pain in last month 1.0 1.3 2.4 1.6 -0.3
Supplements: Glucosamine 1.3 1.8 2.6 1.0 1.6
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.1 0.0 -1.5
Medication: Atenolol 2.2 2.7 3.7 1.3 -1.9
Medication: Levothyroxine sodium 15.6 26.5 52.0 1.0 -7.2
Sitting height 0.4 2.6 5.1 -0.3 2.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 0.5 -0.2
High blood pressure (mother) 1.3 1.8 3.3 0.5 1.8
Body mass index (BMI) 0.4 1.8 3.5 -0.4 -1.9
Impedance of leg (left) 0.3 1.3 2.4 0.4 1.6
Leg predicted mass (left) 0.1 0.4 0.8 -0.0 -0.9
Trunk fat mass 0.3 1.3 2.7 -0.1 -1.6
Waist circumference 0.9 3.3 6.7 -0.1 -2.6
Number of incorrect matches in round 0.1 0.1 0.2 0.1 0.4
Past tobacco smoking 0.2 0.4 0.5 -0.7 0.6
Alcohol usually taken with meals 0.3 0.6 1.1 1.1 0.0
Nervous feelings 0.1 0.1 0.2 -0.5 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.7 0.2 1.3
Hearing difficulty/problems with background noise 0.0 0.0 0.1 0.2 0.1
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.3 0.3
Had menopause 1.7 2.1 4.0 -0.4 -2.0
Had other major operations 0.3 0.4 0.8 -0.1 -0.9
Forced vital capacity (FVC) 0.6 2.2 2.8 1.7 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 -0.8 0.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.6 -0.8 -0.8
Qualifications: None of the above 0.2 0.5 1.0 -0.0 -1.0
Financial difficulties in last 2 years 0.1 0.1 0.3 0.5 -0.0
Mouth/teeth dental problems 0.6 0.9 1.6 -0.4 -1.3
Heart attack 1.4 1.8 2.3 1.1 -1.5
Allergy 5.6 12.9 17.2 4.1 2.9
Pain all over the body in last month 1.0 1.1 1.7 -0.7 -1.3
Diabetes (self-reported) 3.7 5.7 7.8 1.9 -2.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.5 -0.0 0.7
Medication: Ramipril 1.1 1.4 2.6 0.5 -1.6
Medication: Simvastatin 1.3 1.9 3.8 0.1 -1.9
Fluid intelligence score 0.4 0.9 1.8 0.1 1.3
Illnesses of siblings 0.3 0.5 0.9 1.0 -0.2
Neuroticism score 0.2 0.5 0.5 -0.7 0.6
Weight 0.1 0.4 0.9 0.0 -0.9
Impedance of arm (right) 0.1 0.5 0.6 0.6 0.8
Arm fat percentage (right) 0.3 1.0 1.6 -0.6 -1.3
Trunk fat-free mass 0.0 0.1 0.1 0.3 -0.1
Hip circumference 0.0 0.2 0.3 -0.3 -0.6
Time employed in main current job 1.7 2.0 2.3 -1.3 -1.5
Alcohol intake versus 10 years previously 0.0 0.1 0.1 0.1 -0.3
Father’s age at death 2.6 3.5 7.1 2.7 0.2
Worrier / anxious feelings 0.1 0.2 0.3 0.1 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.2 1.5 0.3
Falls in the last year 1.1 1.5 2.8 0.4 -1.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 0.3 -0.5
Number of live births 1.8 2.5 3.1 1.4 -1.8
Forced expiratory volume in 1-second (FEV1) 0.9 3.2 4.3 1.4 2.1
Pulse rate 0.5 0.8 1.6 1.3 0.0
Happiness 1.8 2.1 2.5 1.3 1.6
Noisy workplace 0.0 0.0 0.0 -0.1 0.1
Qualifications: A levels/AS levels or equivalent 0.4 1.0 1.8 1.3 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.6 0.0
Mouth/teeth dental problems: Dentures 0.5 0.8 1.7 -0.0 -1.3
Asthma 5.4 10.6 11.2 -3.3 -3.2
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 1.9 -1.4 0.8
Medication: Cholesterol lowering 0.9 1.3 2.4 -0.5 -1.6
Depression (self-reported) 0.7 0.8 1.5 1.2 0.2
Medication: Lansoprazole 2.6 3.0 5.9 -0.3 -2.4
Prospective memory result 0.2 0.2 0.4 -0.6 -0.3
Lung cancer (father) 1.0 1.1 2.3 -0.0 -1.5
Illnesses of mother 1.4 1.7 3.1 -0.6 1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 2.5 1.5 1.6
Pulse wave Arterial Stiffness index 0.5 0.6 0.6 0.8 -0.7
Impedance of arm (left) 0.1 0.3 0.4 0.6 0.5
Arm fat mass (right) 0.3 1.2 2.3 -0.4 -1.5
Trunk predicted mass 0.0 0.1 0.1 0.4 -0.1
Standing height 0.2 2.4 3.8 1.0 2.0
Length of working week for main job 0.3 0.4 0.4 -0.6 0.6
Exposure to tobacco smoke at home 0.8 0.9 1.7 -1.3 -0.0
Breastfed as a baby 0.0 0.0 0.0 0.0 0.0
Tense / ‘highly strung’ 0.4 0.7 1.4 -1.2 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.1 1.8 -0.8
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 -1.0 -0.1
Birth weight of first child 0.4 0.8 1.3 0.5 1.2
Peak expiratory flow (PEF) 0.2 0.5 0.8 0.5 0.9
Pulse wave reflection index 0.2 0.2 0.4 -0.4 -0.6
Ever highly irritable/argumentative for 2 days 1.8 2.1 4.2 -2.1 0.2
Loud music exposure frequency 1.0 1.1 1.5 -0.8 1.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 3.1 -0.6 1.8
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 0.2 0.1
Blood clot in the leg (DVT) 1.6 2.1 3.8 0.6 -2.0
Medication: Paracetamol 0.2 0.4 0.6 0.5 -0.7
Headache pain in last month 0.3 0.6 0.8 -0.9 -0.6
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 2.0 -1.4 0.9
Glaucoma (self-reported) 0.5 0.6 1.0 0.4 -1.0
Gout (self-reported) 1.1 1.5 2.5 -0.7 -1.6
Hypothyroidism/myxoedema (self-reported) 16.6 32.3 63.2 1.2 -8.0
Medication: Amlodipine 0.2 0.3 0.3 -0.6 -0.6
Medication: Ventolin 100micrograms inhaler 1.9 2.5 2.7 -1.6 -1.5
Birth weight 0.5 1.1 1.3 -0.9 1.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.1 -1.1 -0.5
High blood pressure (siblings) 0.3 0.4 0.7 -0.8 0.3
Forced vital capacity (FVC), Best measure 0.7 2.5 3.4 1.9 1.2
Body fat percentage 0.3 1.3 2.5 -0.3 -1.6
Leg fat percentage (right) 0.2 0.9 1.2 -0.7 -1.1
Arm fat-free mass (right) 0.0 0.0 0.1 0.1 -0.2
Exposure to tobacco smoke outside home 0.1 0.2 0.3 -0.5 0.3
Comparative body size at age 10 0.0 0.1 0.2 0.5 0.0
Number of full brothers 0.0 0.1 0.1 0.3 -0.2
Worry too long after embarrassment 0.6 0.9 1.6 -1.3 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 -0.1 -0.0
Wheeze or whistling in the chest in last year 3.8 6.8 11.9 -1.3 -3.4
Number of children fathered 1.0 1.1 2.1 -1.4 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 0.0 0.0
Age at first live birth 0.1 0.2 0.3 -0.5 0.3
Pulse wave peak to peak time 0.8 0.9 1.1 -0.9 1.1
Health satisfaction 2.3 3.0 5.2 2.3 -0.9
Shortness of breath walking on level ground 0.8 1.0 1.3 0.8 1.1
Qualifications: College or University degree 0.9 3.0 5.4 0.8 2.3
Eye problems/disorders: None of the above 0.2 0.2 0.3 -0.6 0.3
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.6 -1.6 0.7
Emphysema/chronic bronchitis 2.7 3.0 5.9 0.4 -2.4
Medication for pain relief, constipation, heartburn 2.3 4.0 7.7 0.6 2.8
Neck or shoulder pain in last month 1.5 2.1 2.3 1.4 1.5
Medication: Blood pressure 0.3 0.5 0.8 0.9 0.3
Angina (self-reported) 0.4 0.5 0.6 0.8 0.6
Migraine (self-reported) 1.6 2.0 4.0 -0.2 -2.0
Medication: Ibuprofen 1.1 1.3 2.2 -1.5 0.7
Medication: Allopurinol 3.2 4.3 8.1 -0.6 -2.9
Medication: Omeprazole 3.3 3.9 5.0 2.2 -1.7
Medication: Seretide 50 evohaler 0.5 0.6 0.9 -0.9 -0.5
Mean time to correctly identify matches 0.5 1.0 1.7 -0.5 -1.3
Heart disease (mother) 0.9 1.1 2.2 -0.1 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 2.2 1.5 1.3
Whole body fat mass 0.3 1.1 2.2 -0.2 -1.5
Leg fat mass (right) 0.3 1.0 1.8 -0.4 -1.4
Arm predicted mass (right) 0.0 0.1 0.1 0.3 -0.3
Pulse rate, automated reading 0.1 0.4 0.6 0.8 0.5
Alcohol intake frequency. 1.0 2.4 4.3 0.7 -2.1
Comparative height size at age 10 0.0 0.2 0.3 0.5 0.4
Number of full sisters 3.2 3.9 4.8 -1.7 2.2
Suffer from ‘nerves’ 1.4 2.3 3.1 -1.2 -1.8
Overall health rating 0.9 1.9 3.6 -0.5 -1.9
Chest pain or discomfort 0.4 0.6 1.2 -1.1 -0.1
Had major operations 1.2 1.4 1.7 -1.3 -1.1
Age at last live birth 0.0 0.0 0.1 -0.3 0.1
Family relationship satisfaction 0.0 0.0 0.0 -0.0 -0.1
Leg pain on walking 2.2 2.8 5.6 2.4 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.6 0.8 -0.5
Commuting to job workplace: Car/motor vehicle 1.0 1.1 1.6 -0.8 -1.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.6 0.8 0.4
Medication: Aspirin 2.2 2.9 4.9 0.9 -2.2
Supplements: Vitamin C 0.7 0.8 1.5 1.2 0.3
Knee pain experienced in last month 0.2 0.4 0.7 0.9 -0.0
Hypertension (Self-reported) 0.1 0.3 0.4 0.4 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 2.1 0.4 -1.4
Illnesses of father: Heart disease 2.3 3.2 6.2 0.3 2.5
Illnesses of siblings: Diabetes 1.5 1.9 2.7 -1.6 -1.1
Smoking status: Previous 0.1 0.1 0.2 -0.0 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.0 0.4
Whole body fat-free mass 0.0 0.1 0.1 0.4 -0.3
Leg fat-free mass (right) 0.1 0.3 0.4 0.4 -0.7
Arm fat percentage (left) 0.4 1.4 2.5 -0.6 -1.6
Average weekly red wine intake 4.3 6.3 7.1 2.4 2.7
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.4 0.6 0.6
Mood swings 0.5 0.9 1.1 -1.1 0.8
Loneliness, isolation 1.4 2.0 2.5 -1.6 1.2
Long-standing illness, disability or infirmity 6.6 10.1 20.1 -0.3 -4.5
Ever had bowel cancer screening 2.1 2.5 3.0 1.7 -1.4
Diabetes diagnosed by doctor 4.3 7.1 11.0 1.8 -3.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 -0.7 -0.0
Friendships satisfaction 0.9 1.1 2.0 -0.5 1.4
Qualifications: nursing, teaching 0.1 0.1 0.1 0.4 0.1
Commuting to job workplace: Walk 1.7 1.8 2.5 1.1 1.6
Eye problems/disorders: Cataract 0.0 0.1 0.1 -0.0 -0.3
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 5.8 0.7 2.4
Medication for cholesterol 1.0 1.5 2.9 0.3 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.6 -0.6 -0.8
Back pain experienced in last month 0.3 0.5 0.6 0.7 0.6
Mineral and other dietary supplements 1.5 2.1 2.7 -1.6 -1.2
Breast cancer (self-reported) 1.3 1.5 3.0 -0.2 -1.7
Asthma (self-reported) 5.9 11.7 12.2 -3.3 -3.5
Osteoporosis (self-reported) 1.6 2.0 4.0 0.2 -2.0
Osteoarthritis (self-reported) 0.0 0.0 0.1 -0.2 -0.1
Medication: Aspirin 2.2 2.9 5.2 0.8 -2.3
Medication: Gliclazide 0.3 0.3 0.5 0.3 -0.7
Illnesses of father: None of the above (group 1) 0.2 0.3 0.3 -0.5 0.5
Smoking status: Current 0.8 1.3 1.8 0.8 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 1.0 0.3
Whole body water mass 0.0 0.1 0.1 0.3 -0.3
Leg predicted mass (right) 0.1 0.3 0.5 0.4 -0.7
Arm fat mass (left) 0.3 1.1 2.0 -0.4 -1.4
Number of self-reported non-cancer illnesses 6.7 11.6 18.6 2.1 -4.3
Average weekly champagne plus white wine intake 0.7 0.9 1.7 0.3 1.3
Miserableness 0.3 0.5 0.5 0.7 -0.7
Guilty feelings 0.1 0.1 0.2 -0.0 0.5
Wears glasses or contact lenses 1.4 1.6 2.6 -1.6 -0.8
Ever taken oral contraceptive pill 0.3 0.3 0.4 -0.6 0.5
Hearing aid user 1.6 1.8 2.6 1.0 -1.6
Mother’s age at death 0.4 0.5 0.9 1.0 0.1
Financial situation satisfaction 1.9 2.3 4.6 0.1 2.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.4 1.2 0.5
Commuting to job workplace: Public transport 0.1 0.1 0.1 0.2 0.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 -0.5 -0.5
Medication: Blood pressure 1.3 2.4 3.5 -1.2 -1.9
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.5 0.6 -0.7
Supplements: Fish oil (including cod liver oil) 2.8 3.7 4.3 1.7 2.1
High cholesterol (Self-reported) 0.6 1.0 1.3 0.8 -1.2
Medication: Bendroflumethiazide 0.3 0.4 0.6 0.8 0.5
Medication: Paracetamol 0.1 0.2 0.2 0.4 -0.5
Medication: Lisinopril 0.2 0.3 0.4 0.3 0.6
Medication: Atorvastatin 0.6 0.8 1.5 -1.2 0.1
Illnesses of father: High blood pressure 0.7 0.9 1.4 -1.2 -0.7
Alcohol drinker status: Never 0.1 0.1 0.1 0.4 0.2
Ever smoked 0.1 0.1 0.3 0.1 -0.5
Basal metabolic rate 0.0 0.1 0.2 0.3 -0.4
Leg fat percentage (left) 0.2 0.7 1.3 -0.3 -1.1
Arm fat-free mass (left) 0.0 0.1 0.2 0.1 -0.5
Number of operations (self-reported) 0.0 0.0 0.1 0.1 0.3
Average weekly beer plus cider intake 0.3 0.4 0.6 -0.5 0.7
Irritability 0.5 0.8 0.9 -0.8 -0.9
Risk taking 0.8 1.2 2.4 -1.5 -0.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.0 -0.6 1.0
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.0 -0.4
Age started oral contraceptive pill 0.6 0.8 1.3 0.5 -1.2
Diastolic blood pressure, automated reading 0.6 1.9 2.7 1.0 1.6
Ever depressed for a whole week 0.6 0.8 1.5 0.3 -1.2
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.2 0.4
Commuting to job workplace: Cycle 1.9 2.2 4.4 -0.3 2.1
Myopia 0.0 0.0 0.1 -0.1 0.3
Vascular/heart problems diagnosed by doctor 0.2 0.6 0.7 -0.8 0.8
Cholesterol lowering medication 0.4 0.6 0.9 -0.6 -0.9
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 3.8 1.9 -1.8
Pain experienced in last month 0.1 0.1 0.1 -0.3 -0.3
Supplements: Calcium 0.6 0.6 1.2 1.1 -0.3
Basal cell carcinoma (self-reported) 1.3 1.5 3.0 0.2 1.7
Heart attack/myocardial infarction (self-reported) 1.1 1.4 1.5 1.1 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.9 2.4 4.4 0.7 -2.1
Heart disease (siblings) 0.1 0.1 0.2 0.4 -0.2
Alcohol drinker status: Previous 4.2 4.7 7.4 1.4 -2.7
Pack years of smoking 0.6 0.9 1.8 1.3 0.0
Impedance of whole body 0.2 1.0 1.1 0.9 1.1
Leg fat mass (left) 0.3 1.0 2.0 -0.3 -1.4
Arm predicted mass (left) 0.0 0.2 0.3 0.5 -0.2