TWAS hub - IL2RA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0670	0.0245	0.0022	0.017	0.017	0.017	0.017	0.017	0.0012	0.0011	1.3e-03	0.0011	0.0010
2	TCGA	Liver Hepatocellular Carcinoma	0.1390	0.0670	0.0045	-0.006	0.051	0.028	NA	0.004	0.9300	0.0019	1.7e-02	NA	0.1900
3	TCGA	Prostate Adenocarcinoma	0.0634	0.0291	0.0016	0.011	0.016	0.010	NA	0.004	0.0200	0.0068	3.0e-02	NA	0.1100
4	TCGA	Stomach Adenocarcinoma	0.0910	0.0470	0.0083	0.027	0.036	0.053	NA	0.035	0.0048	0.0013	9.8e-05	NA	0.0015

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Allergy or Eczema	10.1	26.6	51.6	6.4	-3.8	-0.1	-7.2
Hayfever, allergic rhinitis or eczema	10.0	21.7	42.9	5.9	-3.0	-0.2	-6.5
Allergy	9.1	20.9	37.6	-5.7	3.6	0.7	6.1
Hypothyroidism (self reported)	7.9	18.1	30.1	3.3	-5.5	-5.3	-1.9
Hypothyroidism/myxoedema (self-reported)	6.9	13.4	22.6	2.2	-4.6	-4.8	-2.2
Medication: Levothyroxine sodium	6.2	10.4	17.5	2.3	-4.0	-4.2	-1.7
Respiratory disease	5.9	13.2	17.8	3.6	-3.8	-2.8	-4.2
Taking other prescription medications	5.0	7.7	12.0	3.5	-3.0	-2.3	-2.0
Illnesses of siblings: Diabetes	4.7	5.8	15.1	0.1	-2.4	-3.9	-1.6
Alzheimer’s Disease (in mother)	4.1	4.8	7.0	0.4	-2.6	-2.6	-2.3
Asthma (self-reported)	4.1	8.1	10.3	3.0	-3.2	-2.0	-3.0
Crohns Disease (2017)	3.7	8.2	13.6	3.5	2.4	3.7	0.7
Asthma	3.7	7.3	9.7	2.8	-3.1	-1.8	-2.9
Irritable Bowel Disease (IBD)	3.5	8.4	12.6	3.6	2.4	3.5	1.8
Long-standing illness, disability or infirmity	3.3	5.0	7.0	2.2	-2.5	-2.7	-1.4
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	12.0	1.9	-0.4	-0.3	-3.5
Mean Putamen Volume	2.9	3.3	7.5	-0.4	2.7	1.7	1.6
Alzheimer’s Disease (including proxy)	2.8	4.1	6.8	0.8	-2.2	-2.6	-2.1
Ulcerative Colitis (UC)	2.7	5.0	8.3	2.9	1.7	2.1	2.1
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	4.3	-1.0	-1.8	-1.9	-2.1
Average weekly red wine intake	2.6	3.8	6.6	-1.8	2.6	1.9	1.3
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	8.8	-2.0	1.4	3.0	1.2
Medication: Allopurinol	2.5	3.3	5.8	1.7	-1.7	-2.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	3.7	1.9	1.3	1.8	1.6
Bipolar Disorder (2011)	2.3	2.3	3.3	1.8	1.3	1.8	0.9
Crohns Disease (2012)	2.2	3.5	6.1	1.8	1.9	2.5	1.1
Primary Biliary Cirrhosis	2.2	3.2	9.7	1.4	0.8	3.1	0.7
Ulcerative Colitis	2.2	3.1	5.0	1.6	1.4	1.7	2.2
Supplements: Zinc	2.2	2.4	4.8	0.3	-2.2	-1.8	-1.2
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	6.5	-0.4	-2.5	-1.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	7.3	2.7	-0.4	1.1	-0.8
Mineral and other dietary supplements	2.2	2.9	4.7	-0.1	-2.2	-1.8	-1.9
Eye problems/disorders: Glaucoma	2.2	2.5	3.3	-1.8	-1.6	-1.4	-1.6
Family relationship satisfaction	2.1	2.6	4.4	0.0	-1.8	-2.1	-1.6
Blood Eosinophil Count	2.0	15.5	37.5	6.1	-3.3	-2.4	-2.9
Vitamin and mineral supplements	2.0	2.7	4.5	-0.1	-1.5	-2.0	-2.1
Emphysema/chronic bronchitis	2.0	2.3	3.9	1.2	-2.0	-1.1	-1.6
Worry (Nagel 2018)	1.9	4.0	7.6	0.2	2.4	2.8	1.7
Pack years adult smoking proportion	1.9	2.9	5.1	-2.3	1.5	1.6	1.3
Age at first live birth	1.9	3.3	4.4	1.8	-2.1	-1.4	-1.9
Age at last live birth	1.9	2.8	3.8	2.0	-2.0	-1.5	-1.1
Number of self-reported non-cancer illnesses	1.9	3.3	5.2	1.6	-2.3	-1.4	-1.8
Pack years of smoking	1.9	2.8	4.7	-2.2	1.5	1.6	1.3
Age at First Birth	1.8	2.7	4.5	-1.6	-1.6	-2.1	-1.1
Wheeze or whistling in the chest in last year	1.8	3.3	4.0	1.8	-2.0	-1.7	-1.7
Neuroticism (Nagel 2018)	1.7	4.1	6.2	1.1	2.5	2.4	1.8
Birth weight of first child	1.7	3.1	6.2	-2.5	-1.4	-1.8	-1.0
Medication: Lisinopril	1.7	2.1	4.5	0.6	-1.2	-1.5	-2.1
Number of treatments/medications taken	1.6	2.8	4.2	1.7	-2.0	-1.7	-1.0
Multivitamins +/- minerals	1.5	1.9	2.9	-0.4	1.6	1.7	1.4
Prospective memory result	1.5	1.8	2.5	-1.5	-0.8	-1.6	-1.4
Lung cancer (father)	1.5	1.7	4.9	-0.4	-1.1	-2.2	-0.7
Ever taken oral contraceptive pill	1.5	1.7	3.3	0.1	-1.8	-1.5	-1.1
Type 2 Diabetes (T2D) (2012)	1.4	1.7	2.8	-0.1	-1.2	-1.5	-1.7
Sensitivity / hurt feelings	1.4	2.4	3.6	1.3	1.9	1.8	0.9
Happiness	1.4	1.8	2.4	-1.6	-1.5	-1.1	-1.1
Exposure to tobacco smoke at home	1.4	1.5	4.1	1.2	0.7	2.0	0.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	2.4	1.3	-1.6	-0.8	-1.6
Medication: Gliclazide	1.4	1.6	3.7	1.9	0.6	1.5	0.2
Hearing aid user	1.4	1.6	3.8	1.4	-0.6	-0.3	-1.9
Diastolic blood pressure, automated reading	1.4	4.2	13.5	-3.7	0.3	-0.5	1.7
HbA1C	1.3	1.4	4.5	-0.0	-1.0	0.4	-2.1
Waist circumference	1.3	4.6	9.0	-2.0	-2.2	-3.0	-0.8
Nervous feelings	1.3	2.4	4.9	-0.8	1.9	2.2	0.6
Illnesses of siblings	1.3	1.8	3.5	1.8	0.7	1.9	-0.1
Worrier / anxious feelings	1.3	2.5	6.2	1.2	1.3	2.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.7	-2.8	0.2	-1.5	0.9
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.6	1.5	0.9	1.6	0.2
Commuting to job workplace: Public transport	1.3	1.5	3.5	-1.1	-1.0	-1.9	-0.6
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.0	0.0	2.0	1.4	0.9
Type 2 Diabetes (T2D) (2018)	1.2	2.2	8.2	2.9	-0.2	0.6	0.4
Supplements: Glucosamine	1.2	1.5	2.4	-1.3	1.5	0.8	1.2
Had other major operations	1.2	1.5	3.3	-0.1	-1.6	-1.8	-0.4
Medication: Lansoprazole	1.2	1.3	1.7	1.0	-1.0	-1.3	-1.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.0	0.7	-1.0	-0.9	-2.0
Medication for pain relief, constipation, heartburn	1.2	2.0	3.7	-0.6	1.9	1.6	1.1
Commuting to job workplace: Car/motor vehicle	1.2	1.3	4.3	2.1	-0.4	0.1	-0.9
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.2	-2.0	0.1	1.3	0.3
Rheumatoid Arthritis	1.1	1.5	2.7	1.6	-1.1	0.0	1.4
Waist Hip Ratio (WHR)	1.1	4.8	10.8	-0.7	-2.6	-3.3	-1.1
Serious illness, injury or assault to yourself	1.1	1.3	4.0	2.0	-0.7	0.8	0.0
Hearing difficulty/problems with background noise	1.1	1.8	3.4	1.8	0.6	1.8	0.4
Gout (self-reported)	1.1	1.5	2.6	1.6	-0.9	-1.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.6	0.3	1.5	1.6	0.5
Health satisfaction	1.1	1.5	3.6	0.1	-1.1	-1.9	-1.1
Average weekly champagne plus white wine intake	1.1	1.5	3.7	1.9	0.5	1.3	0.7
Commuting to job workplace: Cycle	1.1	1.3	3.6	-1.9	0.3	0.7	1.0
Alcohol drinker status: Previous	1.1	1.3	4.3	2.1	-0.8	0.2	-0.6
Neuroticism	1.0	2.3	5.0	0.6	2.2	1.8	0.8
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.5	-0.1	-1.5	-1.6	-0.2
Medication: Metformin	1.0	1.4	4.2	2.0	-0.6	-0.0	-1.0
Number of incorrect matches in round	1.0	1.7	4.5	-0.4	1.5	2.1	0.3
Exposure to tobacco smoke outside home	1.0	1.3	3.9	-0.4	1.0	2.0	0.1
Ever depressed for a whole week	1.0	1.2	3.3	0.0	-1.8	-1.1	-0.7
Unable to work because of sickness or disability	1.0	1.3	2.3	1.2	1.5	1.1	0.6
Lupus	0.9	1.4	2.1	1.4	-0.8	0.9	-1.4
BMI	0.9	5.3	8.4	-1.7	-2.6	-2.9	-1.8
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.9	-2.0	-0.6	-0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.9	2.0	-0.2	-0.8	0.4
Ever had hysterectomy (womb removed)	0.9	1.1	2.9	-0.5	-1.7	-0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	5.2	-2.3	-0.6	-0.3	-0.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.1	-0.6	-1.4	-1.5	-0.2
Loud music exposure frequency	0.9	1.0	2.7	1.0	-0.0	-0.4	-1.6
Medication: Paracetamol	0.9	1.4	3.0	0.1	-1.5	-1.7	-0.7
High blood pressure (siblings)	0.9	1.3	4.0	-2.0	-0.2	-0.3	1.1
Medication: Seretide 50 evohaler	0.9	1.0	2.6	1.1	-0.4	-0.2	-1.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.5	-0.5	1.9	0.9	-0.1
Illnesses of father: Heart disease	0.9	1.3	3.2	-0.8	1.1	1.8	0.1
Diabetes diagnosed by doctor	0.9	1.5	4.7	2.2	-1.0	-0.4	-0.5
Commuting to job workplace: Walk	0.9	0.9	3.2	-1.8	0.4	-0.5	0.4
Osteoarthritis (self-reported)	0.9	1.1	2.3	0.8	0.5	1.5	1.1
Financial situation satisfaction	0.9	1.1	2.5	-1.6	-0.7	-1.1	0.4
Supplements: Calcium	0.9	1.0	3.5	0.2	-0.8	-0.1	-1.9
Hearing difficulty/problems: Yes	0.8	1.3	3.2	1.8	0.1	1.2	-0.7
Current tobacco smoking	0.8	1.3	3.6	0.3	-1.3	-1.9	0.1
Mouth/teeth dental problems	0.8	1.2	1.8	0.9	-1.4	-1.2	-0.9
Diabetes (self-reported)	0.8	1.3	3.7	1.9	-0.8	-0.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.2	-0.5	-1.5	-1.1	-0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	1.6	-1.1	0.5	-0.9	1.3
Smoking status: Current	0.8	1.2	3.5	0.2	-1.1	-1.9	0.1
Number of operations (self-reported)	0.8	1.2	3.4	-1.0	0.8	-0.0	1.8
Schizophrenia vs Biploar Disorder	0.7	1.0	1.6	-0.9	1.3	0.3	1.2
Breast Cancer	0.7	1.6	6.2	2.5	-0.2	0.3	0.4
Diabetes (father)	0.7	0.9	1.7	0.8	-1.3	-0.3	-1.1
Maternal smoking around birth	0.7	1.0	1.9	-0.9	-0.2	-1.1	1.4
Body mass index (BMI)	0.7	3.2	6.2	-1.9	-1.6	-2.5	-0.6
Qualifications: None of the above	0.7	1.5	3.0	0.5	1.7	1.6	0.4
Depression (self-reported)	0.7	0.9	3.1	-1.8	0.3	0.1	0.4
Pulse rate, automated reading	0.7	2.1	3.7	-1.3	1.9	0.7	1.6
Osteoporosis (self-reported)	0.7	0.9	2.3	1.5	-1.0	-0.4	-0.3
Medication: Blood pressure	0.7	1.4	2.1	1.0	-1.4	-0.6	-1.5
Medication: Bendroflumethiazide	0.7	1.0	1.8	1.0	-0.7	-1.4	-0.9
Alcohol drinker status: Never	0.7	0.8	2.0	-1.0	0.0	-1.4	0.7
Ever smoked	0.7	1.3	3.3	-0.3	-0.6	-1.8	-1.1
Irritability	0.7	1.2	2.8	1.1	1.7	0.8	0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	1.0	0.4	0.2	-1.5
Myopia	0.7	1.0	2.9	0.6	0.9	0.2	1.7
Cholesterol lowering medication	0.7	1.0	2.5	1.6	-0.8	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.6	-1.6	-0.0	-0.0	1.1
Prostate Cancer	0.6	0.8	2.0	-1.0	-0.3	-1.4	-0.2
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	0.3	-0.8	-0.9	-1.4
Fasting Glucose	0.6	0.7	0.9	0.8	1.0	0.7	0.8
HDL Cholesterol	0.6	1.0	2.8	0.0	-1.7	-0.7	-0.8
Medication for hormone replacement therapy	0.6	0.7	1.6	0.8	-1.3	-0.7	-0.2
Qualifications: CSEs or equivalent	0.6	0.8	2.3	-1.5	-0.5	-0.8	-0.4
Impedance of leg (left)	0.6	3.0	6.8	0.7	1.5	2.6	1.6
Heart attack	0.6	0.7	1.5	1.2	0.2	1.0	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	-1.0	0.2	0.1	-1.3
Neck or shoulder pain in last month	0.6	0.8	2.2	-1.5	0.5	0.5	0.6
Ever had bowel cancer screening	0.6	0.6	1.3	0.7	-0.9	-1.1	-0.2
Wears glasses or contact lenses	0.6	0.7	1.5	-0.3	-1.0	-1.2	-0.3
Medication: Paracetamol	0.6	0.9	1.7	-0.0	-1.3	-1.3	-0.5
Impedance of whole body	0.6	2.9	5.9	1.2	1.2	2.4	1.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.2	0.3	1.5	1.0	0.9
Ovarian Cancer	0.5	0.6	1.0	0.8	1.0	0.6	0.7
Lung FVC	0.5	2.5	4.4	-0.2	2.1	1.1	2.0
Average weekly spirits intake	0.5	0.6	1.9	0.6	1.4	0.1	0.3
Diabetes (mother)	0.5	0.7	1.0	-0.7	-1.0	-0.8	0.6
Impedance of leg (right)	0.5	2.7	5.7	0.5	1.4	2.4	1.7
Average weekly fortified wine intake	0.5	0.5	0.8	-0.9	0.8	0.4	0.7
Stomach or abdominal pain in last month	0.5	0.7	1.5	-0.1	1.2	0.8	0.7
Medication: Ramipril	0.5	0.7	1.2	1.1	-0.4	-1.1	-0.6
Neuroticism score	0.5	1.0	2.1	0.4	1.5	1.2	0.5
Arm fat percentage (right)	0.5	1.8	3.9	-2.0	-0.9	-1.6	-0.1
Alcohol intake versus 10 years previously	0.5	0.7	2.5	-0.6	0.2	0.2	1.6
Pulse rate	0.5	0.9	1.9	-0.8	1.0	0.4	1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.2	0.1	1.0	0.3	1.5
Breastfed as a baby	0.5	0.6	1.8	-0.7	-0.1	-0.2	1.3
Blood clot in the leg (DVT)	0.5	0.7	1.7	-1.3	0.1	0.2	1.0
Comparative body size at age 10	0.5	1.5	2.6	-0.8	-1.2	-1.6	-1.1
Migraine (self-reported)	0.5	0.6	0.9	0.9	-0.0	0.8	-1.0
Medication: Aspirin	0.5	0.7	2.3	1.5	-0.6	-0.4	-0.2
Arm fat percentage (left)	0.5	2.0	3.3	-1.8	-1.3	-1.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	0.1	-1.3	-0.9	0.0
Back pain experienced in last month	0.5	0.8	1.3	-1.1	0.6	-0.5	1.1
Medication: Aspirin	0.5	0.7	2.6	1.6	-0.0	-0.1	0.5
High cholesterol (Self-reported)	0.5	1.0	2.6	0.5	-1.6	-0.1	-1.0
Average weekly beer plus cider intake	0.5	0.8	1.9	-0.9	-0.1	0.5	1.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	0.5	0.7	1.1	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	1.2	0.3	0.9	0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.9	0.5	-0.1	0.7	-1.7
Angina	0.4	0.5	1.5	-0.6	0.5	0.1	1.2
Hand grip strength (right)	0.4	1.1	2.3	0.2	1.5	0.8	1.1
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	0.9	-0.5	-0.2	-0.8
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	0.3	0.9	0.6	1.1
Had menopause	0.4	0.5	1.4	0.6	0.4	-0.1	1.2
Medication: Simvastatin	0.4	0.6	1.5	0.8	-0.0	0.6	1.2
Impedance of arm (right)	0.4	1.8	2.9	1.0	1.3	1.7	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	-0.3	-1.3	-0.5	-0.6
Number of live births	0.4	0.6	1.8	1.3	-0.4	-0.1	0.6
Noisy workplace	0.4	0.5	1.2	-0.6	1.1	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.4	-1.1	1.4	0.2	1.6
Arm fat mass (right)	0.4	1.5	2.6	-1.5	-1.0	-1.6	-0.3
Length of working week for main job	0.4	0.4	0.7	0.8	-0.1	0.8	0.7
Peak expiratory flow (PEF)	0.4	0.9	1.8	-0.3	1.0	-0.7	1.3
Glaucoma (self-reported)	0.4	0.4	0.7	-0.9	-0.6	-0.2	-0.8
Birth weight	0.4	0.8	1.2	0.9	1.1	0.7	0.9
Angina (self-reported)	0.4	0.5	1.3	-0.5	0.5	0.1	1.2
Medication: Ibuprofen	0.4	0.4	1.2	-0.4	-1.1	-0.6	-0.3
Medication: Omeprazole	0.4	0.5	1.1	-0.3	0.4	0.7	1.0
Whole body fat mass	0.4	1.5	2.3	-1.4	-1.3	-1.5	-0.1
Leg fat mass (right)	0.4	1.7	3.2	-1.8	-1.2	-1.5	-0.1
Alcohol intake frequency.	0.4	0.9	2.3	0.7	0.9	0.4	1.5
Chest pain or discomfort	0.4	0.5	0.9	-0.5	-0.4	-0.9	-0.9
Supplements: Vitamin C	0.4	0.5	1.0	-0.3	0.8	1.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-1.0	-0.8	-0.6	0.2
Loneliness, isolation	0.4	0.5	1.1	0.5	0.7	0.5	1.1
Arm fat mass (left)	0.4	1.7	2.8	-1.6	-1.1	-1.7	-0.3
Leg fat percentage (left)	0.4	1.3	3.6	-1.9	-0.8	-1.0	-0.0
Risk taking	0.4	0.7	2.4	0.3	0.1	0.4	1.5
Leg fat mass (left)	0.4	1.7	3.2	-1.8	-1.2	-1.4	-0.2
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.3	0.2	1.0	-0.9
Schizophrenia (2018)	0.3	0.7	2.0	0.8	-0.4	-0.0	-1.4
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.6	-0.5	-0.2	-0.8
Major Depression (MDD)	0.3	0.4	1.3	0.4	0.1	0.4	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-0.3	-0.8	-0.6	-1.3
LDL Cholesterol	0.3	0.4	1.3	-1.1	-0.1	0.1	0.6
Neuroticism (2016)	0.3	0.5	1.1	0.4	0.8	1.0	0.4
Chronotype (morning person)	0.3	0.6	2.0	-0.0	-0.6	0.1	-1.4
Systolic blood pressure, automated reading	0.3	0.8	1.9	-1.4	0.0	-0.2	1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-1.0	-0.2	-0.6	-0.0
Leg fat-free mass (left)	0.3	1.5	3.9	-0.9	-0.9	-2.0	-0.7
Leg predicted mass (left)	0.3	1.6	4.0	-0.8	-1.0	-2.0	-0.8
Fluid intelligence score	0.3	0.6	1.9	1.4	0.3	0.7	0.1
Weight	0.3	1.7	3.6	-1.5	-0.9	-1.9	-0.1
Falls in the last year	0.3	0.4	1.1	-0.6	0.0	-0.0	1.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	0.1	-0.5	0.2	-1.1
Illnesses of mother	0.3	0.4	1.0	-0.2	1.0	0.7	-0.1
Impedance of arm (left)	0.3	1.3	2.4	1.1	0.9	1.5	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	2.0	0.2	-1.4	-0.6	-0.6
Pulse wave reflection index	0.3	0.4	0.8	-0.5	-0.4	-0.9	0.4
Medication: Amlodipine	0.3	0.4	1.2	0.2	-1.1	-0.6	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.1	1.7	-1.1	1.1	-0.5	1.3
Body fat percentage	0.3	1.2	1.9	-1.4	-1.3	-1.1	0.1
Leg fat percentage (right)	0.3	1.2	3.5	-1.9	-0.8	-0.9	0.1
Worry too long after embarrassment	0.3	0.5	1.2	0.7	1.1	0.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.1	0.7	0.9	0.5
Qualifications: College or University degree	0.3	1.0	2.4	0.9	0.7	1.6	-0.4
Eye problems/disorders: None of the above	0.3	0.4	0.9	0.4	0.5	-0.2	1.0
Heart disease (mother)	0.3	0.3	1.2	-0.2	-0.3	0.2	1.1
Number of full sisters	0.3	0.3	1.1	-1.0	0.5	-0.2	-0.1
Suffer from ‘nerves’	0.3	0.5	1.2	0.3	0.5	1.1	0.5
Leg pain on walking	0.3	0.4	0.6	-0.8	-0.7	-0.7	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.6	0.1	-1.1	-0.0
Knee pain experienced in last month	0.3	0.5	0.9	0.6	-1.0	-0.7	0.3
Smoking status: Previous	0.3	0.4	1.3	1.1	0.2	-0.3	-0.4
Mood swings	0.3	0.5	0.9	-0.3	1.0	0.6	0.7
Eye problems/disorders: Cataract	0.3	0.4	1.1	0.3	0.3	1.1	0.5
Breast cancer (self-reported)	0.3	0.3	0.6	-0.6	-0.8	0.5	-0.2
Miserableness	0.3	0.5	2.0	1.4	-0.2	0.2	-0.3
Mother’s age at death	0.3	0.4	0.6	0.2	0.6	0.7	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.2	-0.9	-0.3	0.8
Depression (Nagel 2018)	0.2	0.3	1.0	-1.0	0.3	-0.3	-0.1
Reaction Time	0.2	0.4	0.9	0.1	-0.4	-1.0	-0.7
Systolic Blood Pressure	0.2	0.9	2.2	-1.5	-1.0	-0.6	0.1
Smoking Status	0.2	0.5	1.4	0.7	-0.1	-1.2	0.3
Lung FEV1/FVC ratio	0.2	1.0	3.6	-1.9	0.3	0.4	0.1
Hand grip strength (left)	0.2	0.4	1.0	-0.1	1.0	0.6	0.5
Medication: Co-codamol	0.2	0.2	0.4	-0.3	0.6	-0.1	0.7
Severe depression (siblings)	0.2	0.2	0.6	-0.1	-0.8	0.1	-0.3
Trunk fat percentage	0.2	0.8	1.2	-1.1	-1.0	-0.8	0.5
Relative age voice broke	0.2	0.3	0.7	0.8	0.2	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	-0.1	-0.1	-1.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.3	-0.1	-0.8	0.2
Medication: Atenolol	0.2	0.3	1.1	0.1	-1.0	-0.2	-0.2
High blood pressure (mother)	0.2	0.3	0.6	-0.6	0.8	0.1	0.5
Trunk fat mass	0.2	1.0	1.5	-1.2	-1.1	-1.2	0.1
Past tobacco smoking	0.2	0.3	1.0	-0.0	-0.1	1.0	0.3
Alcohol usually taken with meals	0.2	0.3	0.5	-0.3	0.6	0.3	-0.7
Forced vital capacity (FVC)	0.2	0.7	1.1	-0.0	1.0	-0.8	1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.2	-0.3	-0.7	-0.8
Hip circumference	0.2	1.0	3.2	-1.8	0.0	-0.8	0.2
Time employed in main current job	0.2	0.3	0.6	-0.3	-0.8	-0.3	-0.5
Father’s age at death	0.2	0.2	0.8	0.0	-0.9	0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	-0.6	1.0	-0.5	0.9
Medication: Cholesterol lowering	0.2	0.3	0.5	0.7	-0.6	-0.5	-0.3
Standing height	0.2	1.6	2.4	0.6	1.6	1.5	1.2
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	0.5	0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.9	0.3	0.5	0.6
Headache pain in last month	0.2	0.3	0.7	0.9	-0.0	-0.0	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.5	0.6	0.7	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.8	0.0	0.5	0.5
Number of full brothers	0.2	0.2	0.5	0.6	0.1	0.0	-0.7
Number of children fathered	0.2	0.2	0.8	-0.9	-0.2	-0.3	0.1
Medication: Blood pressure	0.2	0.4	0.7	-0.8	0.3	-0.3	0.9
Comparative height size at age 10	0.2	1.0	2.0	1.4	0.9	0.7	1.0
Overall health rating	0.2	0.5	0.7	0.4	-0.9	-0.8	0.6
Whole body fat-free mass	0.2	1.1	3.0	-0.8	-0.6	-1.7	-0.6
Leg fat-free mass (right)	0.2	1.3	3.4	-0.6	-0.8	-1.9	-0.9
Friendships satisfaction	0.2	0.2	0.7	-0.5	-0.0	-0.8	-0.0
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.4	-0.8	-0.7	-0.1
Medication for cholesterol	0.2	0.3	0.9	-0.4	0.9	-0.4	-0.3
Whole body water mass	0.2	1.2	3.1	-0.8	-0.7	-1.8	-0.7
Leg predicted mass (right)	0.2	1.3	3.5	-0.6	-0.9	-1.9	-0.8
Medication: Atorvastatin	0.2	0.2	0.7	0.2	-0.8	-0.3	0.3
Basal metabolic rate	0.2	1.3	3.4	-1.1	-0.7	-1.8	-0.5
Arm fat-free mass (left)	0.2	0.9	2.1	-1.1	-0.6	-1.4	-0.1
Heart disease (siblings)	0.2	0.2	0.6	-0.3	-0.4	-0.8	-0.3
Arm predicted mass (left)	0.2	0.8	1.8	-1.2	-0.4	-1.3	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.4	-0.3	0.1	-0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.5	0.0	0.1	0.0
Schizophrenia (2014)	0.1	0.2	0.3	-0.3	-0.6	-0.1	-0.5
Triglycerides	0.1	0.2	0.5	0.0	0.6	0.7	-0.2
Blood Platelet Count	0.1	1.6	3.5	-1.4	1.0	1.9	0.4
Blood Red Count	0.1	1.3	3.2	-0.4	-1.4	-1.8	-0.2
Blood White Count	0.1	0.5	0.7	0.8	0.7	0.5	0.8
Height	0.1	1.3	2.9	1.7	0.9	1.0	0.7
Cardiovascular Disease	0.1	0.3	1.0	-1.0	-0.4	-0.1	0.0
Tanning	0.1	1.1	2.8	1.7	0.7	0.4	-1.1
Relative age of first facial hair	0.1	0.1	0.4	0.6	0.4	-0.2	-0.0
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.5	-0.3	-0.1	0.6
Fed-up feelings	0.1	0.2	0.8	0.2	-0.2	0.1	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.2	0.5	0.5	0.3
Age when periods started (menarche)	0.1	0.3	0.6	0.2	0.3	0.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.2	0.5	0.2	-0.2
High blood pressure	0.1	0.2	0.3	-0.3	0.5	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.6	0.4	-0.8	-0.2
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.0	-0.7	-0.3	-0.2
Trunk fat-free mass	0.1	0.8	2.2	-0.8	-0.3	-1.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	0.0	-0.0	0.5	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.3	-0.3	-0.5	0.1
Trunk predicted mass	0.1	0.7	2.0	-0.8	-0.3	-1.4	-0.4
Arm fat-free mass (right)	0.1	0.5	1.2	-0.7	-0.6	-1.1	-0.2
Pulse wave peak to peak time	0.1	0.1	0.1	-0.3	0.3	0.4	-0.1
Shortness of breath walking on level ground	0.1	0.1	0.4	-0.2	-0.1	-0.6	0.2
Mean time to correctly identify matches	0.1	0.1	0.3	0.5	0.2	-0.4	0.1
Arm predicted mass (right)	0.1	0.7	1.4	-0.9	-0.7	-1.2	-0.2
Had major operations	0.1	0.1	0.3	0.4	0.6	-0.0	0.3
Hypertension (Self-reported)	0.1	0.4	0.8	-0.9	0.3	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.5	0.1	-0.6	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	-0.1	0.5	-0.0
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.6	-0.5	-0.2	-0.3
Age started oral contraceptive pill	0.1	0.2	0.3	0.5	0.1	0.3	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.0	-0.4	-0.2	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	-0.6	-0.1	-0.3	0.4
Pain experienced in last month	0.1	0.2	0.2	0.5	0.4	0.4	-0.4
Heel T-Score	0.0	0.1	0.2	0.4	-0.5	-0.3	0.2
Hair Pigment	0.0	1.1	2.1	1.5	-0.6	1.3	0.5
Sitting height	0.0	0.1	0.5	0.2	0.7	-0.1	-0.0
Pain all over the body in last month	0.0	0.0	0.1	0.3	0.2	-0.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.3	-0.5	0.1	0.0	0.1
Guilty feelings	0.0	0.1	0.2	-0.4	-0.1	-0.1	-0.0

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Trait associations