TWAS hub - PTRF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0240	0.00820	0.000	0.014	0.006	0.014	0.001	0.32000	0.0069	0.0500	0.0063	0.2500
2	GTEx	Nerve Tibial	0.1067	0.0377	0.00077	-0.001	NA	0.026	NA	0.018	0.36000	NA	0.0054	NA	0.0170
3	METSIM	Adipose	0.0318	0.0141	0.00064	0.019	0.004	-0.001	0.004	0.014	0.00064	0.0820	0.4300	0.0770	0.0033

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Irritable Bowel Disease (IBD)	13.3	31.7	65.1	3.3	4.4	8.1
Hypothyroidism/myxoedema (self-reported)	10.6	20.7	28.6	-5.3	-3.2	-4.8
Ulcerative Colitis	9.7	14.1	23.2	1.9	4.0	4.8
Medication: Levothyroxine sodium	9.7	16.5	29.1	-5.4	-1.5	-4.3
Ulcerative Colitis (UC)	9.4	17.6	37.3	2.0	3.4	6.1
Hypothyroidism (self reported)	9.2	21.1	28.4	-4.8	-3.5	-5.3
Crohns Disease (2017)	8.5	18.6	38.2	2.6	3.3	6.2
Crohns Disease (2012)	8.4	13.5	26.5	2.2	3.0	5.2
Long-standing illness, disability or infirmity	6.4	9.7	14.0	-1.2	-3.7	-3.7
Frequency of depressed mood in last 2 weeks	6.1	8.6	10.9	-3.2	-2.2	-3.3
Alzheimer’s Disease (in mother)	5.9	7.0	9.3	-1.6	-3.0	-3.0
Depression (Nagel 2018)	5.4	8.1	12.4	-3.5	-1.3	-3.2
Medication: Co-codamol	5.3	6.1	11.8	-0.8	-2.4	-3.4
Frequency of unenthusiasm / disinterest in last 2 weeks	5.3	7.0	10.8	-2.6	-1.9	-3.3
Heart disease (siblings)	5.0	6.1	12.4	-1.7	-1.7	-3.5
Bipolar Disorder (2018)	4.7	7.5	8.9	3.0	2.2	2.9
Allergy	4.5	10.4	25.4	5.0	1.3	2.0
Hayfever, allergic rhinitis or eczema	4.3	9.3	22.2	-4.7	-1.1	-2.1
Allergy or Eczema	4.2	11.2	28.2	-5.3	-1.1	-2.0
Father’s age at death	4.1	5.5	8.3	-1.5	2.5	2.9
Heart disease (mother)	3.9	4.7	8.8	-1.9	-1.3	-3.0
Fasting Glucose	3.6	4.3	10.5	3.2	-0.1	1.5
Taking other prescription medications	3.6	5.5	10.8	-1.8	-1.6	-3.3
Irritability	3.6	6.1	10.6	-1.4	-2.4	-3.3
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	5.5	-1.9	-2.4	-2.2
Neuroticism (2016)	3.5	5.0	7.8	-1.2	-2.8	-2.4
Neck or shoulder pain in last month	3.5	5.0	11.1	-0.4	-3.3	-1.9
Headache pain in last month	3.4	5.9	7.2	-2.7	-2.2	-2.3
Other serious medical condition/disability diagnosed by doctor	3.3	4.3	6.3	-1.6	-2.0	-2.5
Serious illness, injury or assault to yourself	3.3	4.0	5.8	-2.4	-1.0	-2.3
Medication: Atenolol	3.1	3.8	6.9	-0.2	-2.1	-2.6
Medication: Aspirin	3.1	4.1	7.3	-0.6	-2.7	-2.2
Prostate Cancer	3.0	4.2	6.9	-2.6	-0.6	-2.3
Medication: Metformin	3.0	4.3	6.9	0.6	-2.4	-2.6
Number of full sisters	3.0	3.6	5.8	2.0	0.9	2.4
Schizophrenia vs Biploar Disorder	2.9	3.8	9.0	-3.0	-0.8	-1.3
Mouth/teeth dental problems	2.8	4.3	9.1	0.1	3.0	1.9
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	6.7	-1.6	-2.1	-2.6
Medication: Ventolin 100micrograms inhaler	2.8	3.6	7.0	-2.6	-1.1	-1.7
Wheeze or whistling in the chest in last year	2.8	5.0	9.5	-3.1	-1.7	-1.6
Number of self-reported non-cancer illnesses	2.8	4.8	8.1	-0.8	-2.4	-2.9
Alzheimer’s Disease (including proxy)	2.7	3.9	8.3	-0.8	-2.9	-1.7
Medication: Aspirin	2.7	3.5	5.5	-0.8	-2.4	-2.1
Medication: Gliclazide	2.7	3.1	6.4	0.6	-1.6	-2.5
Alcohol drinker status: Previous	2.7	3.1	4.8	0.8	-2.2	-2.0
Blood clot in the leg (DVT)	2.6	3.3	3.9	-1.6	-2.0	-1.9
Bipolar Disorder (2011)	2.5	2.4	3.1	1.0	1.7	1.8
Rheumatoid Arthritis	2.5	3.5	4.3	-2.1	-1.7	-1.8
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	5.4	-0.2	-2.3	-2.1
Migraine (self-reported)	2.5	3.0	5.8	-1.7	-0.7	-2.4
Respiratory disease	2.4	5.3	14.8	-3.9	0.6	-0.8
Systolic blood pressure, automated reading	2.4	6.9	10.1	3.2	1.2	3.0
Diabetes (father)	2.4	3.0	4.7	0.6	-2.2	-2.0
Asthma	2.3	4.6	13.0	-3.6	0.0	-0.9
Loneliness, isolation	2.3	3.1	5.6	0.8	-2.4	-1.8
Waist Hip Ratio (WHR)	2.2	10.0	25.5	5.0	-0.1	-2.1
Qualifications: CSEs or equivalent	2.2	2.9	4.5	-0.6	-2.0	-2.1
Medication for cholesterol, blood pressure or diabetes	2.2	3.7	5.5	-1.0	2.4	2.1
Asthma (self-reported)	2.2	4.5	12.7	-3.6	0.3	-0.7
Medication: Lisinopril	2.2	2.8	5.5	1.6	-2.3	-0.7
Systolic Blood Pressure	2.1	10.7	22.9	4.8	0.6	3.0
Neuroticism score	2.1	4.3	8.3	-1.4	-1.6	-2.9
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	4.7	-0.5	2.2	1.7
Illnesses of father: Heart disease	2.1	3.0	6.2	-0.7	-1.5	-2.5
High blood pressure (mother)	2.0	2.8	4.5	2.1	0.7	1.8
Noisy workplace	2.0	2.4	6.6	2.6	-0.5	0.7
Tense / ‘highly strung’	2.0	3.2	4.1	-1.2	-2.0	-2.0
Overall health rating	2.0	4.4	6.1	-1.4	-2.5	-2.3
Average weekly red wine intake	2.0	2.9	5.9	-2.4	1.6	0.6
Neuroticism (Nagel 2018)	1.9	4.4	8.7	-1.8	-1.2	-2.9
Medication: Atorvastatin	1.9	2.3	5.2	-0.3	-1.3	-2.3
Height	1.8	34.0	42.4	-4.2	-6.5	-6.5
Type 2 Diabetes (T2D) (2018)	1.8	3.4	7.6	-0.7	-1.5	-2.8
Medication: Lansoprazole	1.8	2.1	2.7	-1.6	-1.1	-1.6
Medication: Blood pressure	1.8	3.2	4.2	1.9	-2.0	-1.4
Alzheimer’s Disease (in father)	1.7	1.8	5.1	0.4	0.5	2.3
Cardiovascular Disease	1.7	5.6	10.2	0.1	-2.6	-3.2
Neuroticism	1.7	4.1	7.1	-1.1	-1.9	-2.7
Worrier / anxious feelings	1.7	3.2	5.7	-1.6	-1.2	-2.4
Peak expiratory flow (PEF)	1.7	4.0	7.8	-2.0	-0.4	-2.8
Comparative height size at age 10	1.7	9.6	13.3	-1.5	-3.6	-3.6
Suffer from ‘nerves’	1.7	2.7	5.2	-1.2	-1.1	-2.3
Mood swings	1.7	3.0	8.7	-0.1	-0.6	-3.0
Diabetes diagnosed by doctor	1.7	2.7	6.3	0.3	-1.3	-2.5
Verbal and Numeric Reasoning (VNR)	1.6	3.9	6.4	1.7	1.5	2.5
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.8	1.5	0.1	1.9
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.2	2.0	-1.2	-0.2
Financial difficulties in last 2 years	1.6	2.1	6.4	2.5	0.1	-0.0
Diabetes (self-reported)	1.6	2.5	5.4	0.7	-1.3	-2.3
Standing height	1.6	15.6	19.4	-2.9	-4.3	-4.4
High blood pressure (siblings)	1.6	2.3	5.8	2.4	-0.2	1.0
Number of children fathered	1.6	1.9	2.8	-1.0	-1.4	-1.7
Medication for pain relief, constipation, heartburn	1.6	2.7	5.1	1.1	1.4	2.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.2	2.1	0.7	0.8
Mother’s age at death	1.6	2.0	6.0	-2.4	-0.0	-0.1
Pain experienced in last month	1.6	2.7	3.8	1.4	1.9	1.5
Coronary Artery Disease (CAD)	1.5	1.8	4.2	-0.3	-1.1	-2.0
Had menopause	1.5	1.9	5.0	0.8	0.3	2.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	2.3	-1.0	-1.5	-1.4
Medication: Cholesterol lowering	1.5	2.3	3.3	1.5	-1.2	-1.8
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.8	-0.0	-1.6	-1.7
Loud music exposure frequency	1.5	1.6	4.0	2.0	0.3	0.8
Had major operations	1.5	1.8	3.8	-1.9	-0.7	-1.1
Leg fat percentage (left)	1.5	5.5	13.3	3.6	-1.2	1.3
Basal cell carcinoma (self-reported)	1.5	1.8	3.0	0.0	1.7	1.5
Leg fat-free mass (left)	1.4	7.3	14.0	-1.8	-2.2	-3.7
Leg predicted mass (left)	1.4	7.3	13.9	-1.7	-2.3	-3.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.3	3.5	-1.2	-1.4	-1.9
Leg fat percentage (right)	1.4	5.0	11.5	3.4	-1.3	1.3
Medication: Allopurinol	1.4	1.8	4.7	0.7	2.2	0.4
Ever taken oral contraceptive pill	1.4	1.6	2.4	1.5	1.1	1.1
Medication: Blood pressure	1.4	2.7	4.5	2.1	0.4	1.9
Fractured/broken bones in last 5 years	1.4	1.9	2.7	-0.9	-1.5	-1.6
Depressed Affect (Nagel 2018)	1.3	2.7	6.6	-0.3	-1.2	-2.6
Breast Cancer	1.3	3.2	8.0	-2.8	-1.3	-0.3
Hearing difficulty/problems: Yes	1.3	2.0	4.2	0.4	1.3	2.0
Ever had hysterectomy (womb removed)	1.3	1.4	1.9	1.3	-0.8	1.4
Trunk fat percentage	1.3	5.1	10.3	3.2	-2.2	-0.4
Pain all over the body in last month	1.3	1.4	3.2	-0.5	-0.9	-1.8
Trunk fat-free mass	1.3	7.5	11.1	-2.6	-2.2	-3.3
Mouth/teeth dental problems: Dentures	1.3	2.1	4.3	0.2	-1.4	-2.1
Trunk predicted mass	1.3	7.3	10.8	-2.5	-2.2	-3.3
Age at first live birth	1.3	2.3	4.5	-2.1	0.6	-1.5
Age at last live birth	1.3	1.9	3.0	-1.7	1.2	-1.2
Leg fat-free mass (right)	1.3	6.8	13.5	-1.8	-1.9	-3.7
Diabetes (mother)	1.2	1.5	2.8	-1.3	-0.1	-1.7
Townsend deprivation index at recruitment	1.2	1.7	4.1	2.0	-0.8	0.5
Falls in the last year	1.2	1.6	3.4	-1.1	-0.4	-1.8
Depression (self-reported)	1.2	1.4	2.7	-0.5	-1.2	-1.6
Body fat percentage	1.2	4.8	11.2	3.4	-1.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.9	-2.0	0.5	0.5
Eye problems/disorders: None of the above	1.2	1.4	2.9	1.7	0.7	0.8
Angina (self-reported)	1.2	1.6	2.7	1.6	-1.0	-1.0
Medication: Ibuprofen	1.2	1.4	2.9	-1.7	0.5	-1.1
Medication: Seretide 50 evohaler	1.2	1.4	2.9	-1.7	-1.0	-0.7
Whole body fat-free mass	1.2	7.0	11.8	-2.1	-2.2	-3.4
Smoking status: Current	1.2	2.0	3.9	2.0	0.6	1.3
Whole body water mass	1.2	6.9	12.0	-2.1	-2.1	-3.5
Leg predicted mass (right)	1.2	6.6	13.3	-1.8	-1.8	-3.6
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.8	1.9	-0.6	0.3
Bipolar Disorder or Schizophrenia	1.1	2.7	4.8	1.4	1.2	2.2
Blood Platelet Count	1.1	12.9	21.2	4.6	2.1	3.6
Angina	1.1	1.4	2.5	1.6	-0.8	-1.1
Average weekly fortified wine intake	1.1	1.2	3.3	-1.8	-0.2	0.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.4	0.9	0.3	1.6
Trunk fat mass	1.1	4.6	6.9	2.2	-2.6	-1.4
Waist circumference	1.1	4.1	7.0	2.6	-1.8	-1.5
Hearing difficulty/problems with background noise	1.1	1.8	4.0	0.6	1.0	2.0
Had other major operations	1.1	1.3	2.7	0.7	0.9	1.6
Medication: Amlodipine	1.1	1.5	3.8	2.0	-0.1	0.8
Health satisfaction	1.1	1.4	2.1	-0.8	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	5.0	0.5	-1.1	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.2	-1.5	-0.1	-1.1
Basal metabolic rate	1.1	6.4	11.2	-1.5	-2.4	-3.3
Body Mass Index (BMI) (2010)	1.0	1.3	2.7	-0.0	1.1	1.7
Primary Biliary Cirrhosis	1.0	1.4	1.7	0.9	-1.3	-1.3
Impedance of leg (right)	1.0	4.7	7.9	2.8	-1.6	1.9
Impedance of leg (left)	1.0	5.1	9.6	3.1	-1.5	1.9
Hair/balding pattern: Pattern 2	1.0	1.3	3.1	-0.3	-1.8	-0.7
Pulse rate, automated reading	1.0	3.2	5.5	-2.3	-1.2	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.4	-1.1	-0.8	-1.2
Cholesterol lowering medication	1.0	1.4	3.0	-0.6	-1.0	-1.7
Sensitivity / hurt feelings	0.9	1.5	3.0	-1.0	-0.6	-1.7
Current tobacco smoking	0.9	1.4	2.8	1.7	0.7	1.0
Fed-up feelings	0.9	1.7	4.6	0.5	-0.6	-2.1
Supplements: Glucosamine	0.9	1.2	1.6	0.8	1.3	1.1
Illnesses of siblings	0.9	1.2	3.2	-1.8	0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	1.9	-1.4	-0.1	-1.3
Pulse wave reflection index	0.9	1.1	2.0	0.2	1.4	1.2
Birth weight	0.9	2.0	2.7	1.5	0.9	1.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.2	1.0	-0.3	1.5
Number of full brothers	0.9	1.1	3.0	1.7	0.3	0.5
Whole body fat mass	0.9	3.9	6.2	2.0	-2.5	-1.2
Back pain experienced in last month	0.9	1.4	3.0	1.0	0.5	1.7
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.1	-1.4	1.1	-0.3
Illnesses of father: High blood pressure	0.9	1.1	1.8	1.4	0.6	1.0
Average weekly beer plus cider intake	0.9	1.3	2.2	1.5	1.3	0.3
LDL Cholesterol	0.8	1.2	1.8	0.9	-1.0	-1.3
Triglycerides	0.8	1.3	2.0	1.4	1.2	0.6
Blood Eosinophil Count	0.8	6.3	9.4	-3.1	-1.1	-2.9
Blood White Count	0.8	5.9	15.3	-1.2	0.9	-3.9
Heel T-Score	0.8	6.0	11.1	3.3	2.4	1.0
High blood pressure	0.8	2.3	6.6	2.6	-0.5	0.3
Qualifications: None of the above	0.8	1.7	3.4	1.9	-1.3	-0.4
Heart attack	0.8	1.0	2.6	-0.3	-0.4	-1.6
Weight	0.8	4.0	6.4	0.1	-2.5	-2.3
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	1.5	1.1	0.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	5.2	-1.6	-0.5	-2.3
Happiness	0.8	0.9	1.9	-1.4	-0.1	-0.9
Breastfed as a baby	0.8	1.0	1.5	0.5	-1.2	1.2
Emphysema/chronic bronchitis	0.8	0.9	2.2	-1.5	-0.1	-0.6
Illnesses of siblings: Diabetes	0.8	0.9	1.3	0.8	-1.1	-1.0
Qualifications: nursing, teaching	0.8	1.2	3.4	-1.8	-0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.1	-0.7	-0.4	1.8
Miserableness	0.8	1.5	3.2	-0.0	-1.1	-1.8
Medication: Bendroflumethiazide	0.8	1.2	2.9	1.7	-0.1	0.8
Age started oral contraceptive pill	0.8	1.0	2.0	0.9	0.5	1.4
Leg fat mass (left)	0.8	3.0	5.8	2.4	-1.7	-0.5
Intelligence (Savage-Jansen 2018)	0.7	2.3	3.5	1.5	1.0	1.9
Worry (Nagel 2018)	0.7	1.5	2.8	-1.2	-0.6	-1.7
Major Depression (MDD)	0.7	0.9	1.5	1.2	-0.2	1.1
HbA1C	0.7	0.7	1.7	0.7	-1.3	-0.2
Lupus	0.7	1.1	2.7	-0.2	-0.7	-1.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	1.2	0.8	0.5
Number of treatments/medications taken	0.7	1.2	2.2	-0.7	-1.0	-1.5
Average weekly spirits intake	0.7	0.9	2.5	-1.6	-0.0	-0.2
Severe depression (siblings)	0.7	0.8	1.5	-1.2	0.9	-0.2
Pack years adult smoking proportion	0.7	1.0	2.3	1.5	0.7	0.5
Sitting height	0.7	5.2	6.9	-1.9	-2.3	-2.6
Medication: Simvastatin	0.7	1.1	2.4	0.5	-0.7	-1.6
Hip circumference	0.7	3.2	6.8	-0.1	-2.6	-1.7
Time employed in main current job	0.7	0.8	1.1	1.1	0.6	0.9
Lung cancer (father)	0.7	0.8	1.1	0.9	1.0	0.7
Gout (self-reported)	0.7	0.9	2.3	-0.3	1.5	-0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.8	-0.4	-0.8	-1.4
Leg fat mass (right)	0.7	2.8	5.2	2.3	-1.8	-0.4
Arm predicted mass (right)	0.7	3.5	5.6	-0.6	-2.1	-2.4
Family relationship satisfaction	0.7	0.9	1.5	-1.2	-0.0	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.3	0.9	0.6	1.1
Hypertension (Self-reported)	0.7	1.9	5.0	2.2	-0.8	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	-0.0	-1.0	-1.3
Ever had bowel cancer screening	0.7	0.9	2.2	0.6	0.2	1.5
Ever smoked	0.7	1.3	1.7	1.0	1.1	1.3
Risk taking	0.7	1.0	1.5	1.2	-0.0	1.2
Supplements: Calcium	0.7	0.8	2.2	-1.5	0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.4	-0.0	-0.6	-1.5
Pack years of smoking	0.7	1.0	2.5	1.6	0.5	0.3
Arm predicted mass (left)	0.7	3.7	6.4	-0.9	-2.0	-2.5
Ovarian Cancer	0.6	0.9	1.5	1.1	-1.2	-0.1
Mean Putamen Volume	0.6	0.6	1.2	1.1	-0.2	0.8
HDL Cholesterol	0.6	1.0	2.4	0.7	-0.1	1.5
Lung FVC	0.6	2.9	5.2	0.1	1.8	2.3
Stomach or abdominal pain in last month	0.6	0.8	1.6	-1.3	0.8	0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.3	-1.5	0.3	0.4
Fluid intelligence score	0.6	1.3	2.7	-1.6	1.0	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.4	-1.1	-0.3	-2.1
Length of working week for main job	0.6	0.6	1.2	0.8	-1.1	0.0
Exposure to tobacco smoke at home	0.6	0.7	1.4	1.2	-0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.2	1.5	0.4	0.7
Arm fat-free mass (right)	0.6	3.2	5.2	-0.7	-2.0	-2.3
Qualifications: College or University degree	0.6	1.8	3.5	-1.9	0.9	1.0
Medication: Omeprazole	0.6	0.7	1.6	1.3	-0.6	0.2
Alcohol intake frequency.	0.6	1.4	2.0	1.1	-1.4	-1.0
Arm fat percentage (left)	0.6	2.2	4.7	2.2	-1.3	-0.5
Financial situation satisfaction	0.6	0.8	1.0	-1.0	-1.0	-0.7
Medication: Paracetamol	0.6	0.9	1.9	-1.4	0.9	-0.0
Arm fat-free mass (left)	0.6	3.2	5.4	-0.9	-1.9	-2.3
Impedance of whole body	0.6	2.8	4.9	2.2	-1.4	1.2
Blood Red Count	0.5	4.4	6.8	2.6	-0.3	2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.4	1.5	-0.0	-1.0
Alcohol usually taken with meals	0.5	0.8	0.8	-0.8	0.9	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.4	1.8	0.2	0.3
Alcohol intake versus 10 years previously	0.5	0.8	1.3	1.1	0.5	0.8
Arm fat mass (right)	0.5	2.2	3.2	1.2	-1.8	-1.4
Forced vital capacity (FVC), Best measure	0.5	1.9	3.5	-1.4	-0.5	-1.9
Exposure to tobacco smoke outside home	0.5	0.7	1.1	-0.5	-0.8	-1.0
Shortness of breath walking on level ground	0.5	0.6	1.3	0.6	-1.1	-0.4
Knee pain experienced in last month	0.5	0.7	1.6	-0.7	-0.2	-1.3
Osteoarthritis (self-reported)	0.5	0.6	1.5	-0.1	0.5	-1.2
Arm fat mass (left)	0.5	2.2	2.9	1.5	-1.7	-1.1
Average weekly champagne plus white wine intake	0.5	0.7	0.9	0.9	-0.7	0.8
Guilty feelings	0.5	0.8	2.1	-1.4	-0.0	-0.5
Wears glasses or contact lenses	0.5	0.5	1.5	0.0	0.3	1.2
Commuting to job workplace: Public transport	0.5	0.6	1.3	-1.2	0.2	0.6
Ever depressed for a whole week	0.5	0.6	1.0	0.8	0.3	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.8	-1.7	0.8	0.7
Relative age of first facial hair	0.4	0.8	1.4	-0.7	1.2	0.7
Relative age voice broke	0.4	0.7	1.9	-1.4	0.4	-0.2
Age when periods started (menarche)	0.4	1.0	2.2	-0.9	-0.0	-1.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.0	1.0	-0.5	0.1
Number of incorrect matches in round	0.4	0.6	1.2	-1.1	-0.7	0.0
Forced vital capacity (FVC)	0.4	1.6	2.9	-1.3	-0.2	-1.7
Arm fat percentage (right)	0.4	1.7	3.6	1.9	-1.1	-0.5
Number of live births	0.4	0.6	1.0	0.9	0.0	1.0
Pulse rate	0.4	0.7	2.0	-1.4	0.0	-0.2
Prospective memory result	0.4	0.5	0.7	-0.8	0.8	-0.0
Birth weight of first child	0.4	0.6	1.8	-1.3	0.3	-0.3
Pulse wave peak to peak time	0.4	0.5	0.9	0.2	-0.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.6	1.0	0.5
Supplements: Vitamin C	0.4	0.5	0.6	-0.8	0.5	-0.7
Smoking status: Previous	0.4	0.6	0.8	-0.9	0.5	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.4	1.1	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.2	-0.4	1.2
High cholesterol (Self-reported)	0.4	0.7	1.8	0.4	-0.3	-1.3
Alcohol drinker status: Never	0.4	0.4	0.6	-0.6	-0.8	0.6
Reaction Time	0.3	0.6	1.3	1.2	0.1	-0.6
Schizophrenia (2014)	0.3	0.8	1.4	-0.6	0.7	1.2
Chronotype (morning person)	0.3	0.6	0.8	-0.6	-0.8	-0.9
Hand grip strength (right)	0.3	0.7	1.4	-0.7	-1.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	-1.4	-0.3	0.3
Medication: Paracetamol	0.3	0.5	0.8	-0.9	0.7	-0.2
Glaucoma (self-reported)	0.3	0.4	0.9	1.0	-0.2	0.3
Comparative body size at age 10	0.3	0.8	1.5	-1.2	0.8	0.4
Chest pain or discomfort	0.3	0.5	1.0	-0.4	-1.0	-0.6
Medication for cholesterol	0.3	0.5	1.2	-1.1	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.6	-0.0	1.2	-0.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	0.8	-0.4	0.4
Commuting to job workplace: Cycle	0.3	0.4	1.0	-0.1	1.0	0.5
Tanning	0.2	2.4	5.1	0.8	1.1	2.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.2	0.4	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.2	-0.5	-0.5
Vitamin and mineral supplements	0.2	0.2	0.6	-0.0	0.0	0.8
Maternal smoking around birth	0.2	0.3	0.5	0.5	-0.7	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.5	-0.6	0.0
Body mass index (BMI)	0.2	0.8	1.8	1.3	-0.6	-0.4
Impedance of arm (right)	0.2	1.0	2.1	1.0	-1.5	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.7	0.2	0.4
Impedance of arm (left)	0.2	1.1	2.1	1.1	-1.5	0.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	0.2	-0.7	1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.5	-0.7	0.4	0.1
Worry too long after embarrassment	0.2	0.3	0.4	-0.6	-0.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.4	-0.4	-0.8
Mean time to correctly identify matches	0.2	0.3	0.8	0.4	0.9	0.2
Friendships satisfaction	0.2	0.2	0.4	-0.3	-0.7	-0.3
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.0	-0.8	-0.4
Number of operations (self-reported)	0.2	0.3	0.7	0.1	-0.2	0.8
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	0.6	-0.5	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.3	0.4	-0.7
Schizophrenia (2018)	0.1	0.3	0.5	-0.7	-0.3	0.5
Age at First Birth	0.1	0.1	0.3	-0.2	0.0	0.5
BMI	0.1	0.5	1.2	1.1	-0.2	-0.5
Smoking Status	0.1	0.3	0.3	0.6	0.5	0.5
Lung FEV1/FVC ratio	0.1	0.6	1.0	0.5	0.8	-1.0
Hair Pigment	0.1	3.4	5.5	-2.3	2.1	0.2
Hand grip strength (left)	0.1	0.4	0.9	-0.9	0.1	-0.5
Supplements: Zinc	0.1	0.1	0.1	0.1	-0.3	0.2
Multivitamins +/- minerals	0.1	0.1	0.4	0.6	-0.0	-0.2
Nervous feelings	0.1	0.2	0.2	-0.5	0.3	-0.5
Medication: Ramipril	0.1	0.1	0.2	-0.2	0.4	-0.5
Illnesses of mother	0.1	0.2	0.5	-0.0	0.7	0.2
Leg pain on walking	0.1	0.2	0.3	0.0	0.6	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.4	0.6	0.2
Commuting to job workplace: Walk	0.1	0.2	0.2	-0.4	-0.5	0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.0	-0.0	0.5
Mineral and other dietary supplements	0.1	0.2	0.6	0.8	-0.1	0.0
Breast cancer (self-reported)	0.1	0.2	0.4	-0.6	-0.2	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.4	-0.3	-0.6
Myopia	0.1	0.2	0.3	-0.1	-0.6	-0.5
Past tobacco smoking	0.0	0.0	0.0	-0.2	-0.2	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.3	0.1	-0.3
Hearing aid user	0.0	0.0	0.1	-0.3	0.1	0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	-0.1	0.3

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