[Hub]/) : Traits : Irritable Bowel Disease (IBD) : ← →

chr1:154,325,302-156,551,848

Best TWAS P=6.87e-12 · Best GWAS P=1.56e-10 conditioned to 0.76

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DAP3	0.03	0.01	blup	248	0.02	1.5e-03	5.3	5.4	5.2e-08	-0.49	0.42	0.24	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FDPS	0.04	0.04	lasso	2	0.04	3.3e-05	5.3	-5.2	1.6e-07	0.50	0.70	0.20	FALSE
3	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	-4.8	-6.3	2.4e-10	0.81	0.16	0.82	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SCAMP3	0.05	0.04	lasso	2	0.03	3.9e-05	5.6	-5.6	2.6e-08	0.53	0.31	0.59	FALSE
5	GTEx	Adipose Subcutaneous	GBAP1	0.10	0.10	lasso	3	0.08	6.1e-07	-6.0	-6.1	8.7e-10	0.96	0.01	0.99	FALSE
6	GTEx	Adipose Subcutaneous	GBA	0.08	0.03	lasso	3	0.02	8.9e-03	-6.0	-6.1	8.6e-10	0.92	0.04	0.87	FALSE
7	GTEx	Adipose Visceral Omentum	GBAP1	0.07	0.11	enet	5	0.10	5.0e-06	-6.3	-6.2	6.0e-10	0.97	0.01	0.98	FALSE
8	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	-6.3	-6.5	7.9e-11	0.94	0.01	0.99	FALSE
9	GTEx	Artery Coronary	HCN3	0.17	-0.01	lasso	6	-0.01	7.4e-01	5.0	-5.2	2.5e-07	0.46	0.06	0.09	FALSE
10	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	-6.2	-6.4	1.2e-10	0.97	0.01	0.99	FALSE
11	GTEx	Brain Cerebellar Hemisphere	THBS3	0.19	0.26	lasso	2	0.24	8.6e-07	-6.4	6.4	1.8e-10	-1.00	0.01	0.99	FALSE
12	GTEx	Brain Cerebellar Hemisphere	EFNA1	0.33	0.04	enet	7	0.08	4.5e-03	-5.8	-6.2	4.6e-10	0.90	0.02	0.69	FALSE
13	GTEx	Brain Cerebellum	MSTO1	0.15	0.06	enet	13	0.07	4.0e-03	6.1	6.3	2.7e-10	-0.81	0.03	0.90	FALSE
14	GTEx	Brain Cerebellum	HCN3	0.16	0.05	lasso	4	0.04	3.1e-02	5.3	-5.4	7.5e-08	0.64	0.08	0.56	FALSE
15	GTEx	Brain Cerebellum	THBS3	0.17	0.15	enet	6	0.16	2.0e-05	-6.4	5.9	3.5e-09	-0.91	0.01	0.98	FALSE
16	GTEx	Brain Cerebellum	EFNA1	0.20	0.09	enet	13	0.06	9.2e-03	6.0	-6.5	1.1e-10	0.91	0.02	0.96	FALSE
17	GTEx	Brain Cortex	GBAP1	0.25	0.14	enet	25	0.23	4.7e-07	-6.0	6.2	7.8e-10	-0.87	0.02	0.98	FALSE
18	GTEx	Breast Mammary Tissue	GBAP1	0.15	0.17	lasso	2	0.15	5.2e-08	-6.2	-6.2	4.4e-10	0.99	0.01	0.99	FALSE
19	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	5.5	-5.5	3.1e-08	0.66	0.03	0.32	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	GBAP1	0.21	0.05	lasso	3	0.06	4.5e-03	-6.0	-6.8	1.4e-11	0.85	0.02	0.96	FALSE
21	GTEx	Cells Transformed fibroblasts	ADAM15	0.14	0.01	lasso	6	0.02	9.3e-03	5.3	-6.5	7.4e-11	0.60	0.39	0.36	FALSE
22	GTEx	Cells Transformed fibroblasts	HCN3	0.05	0.05	lasso	5	0.06	3.8e-05	5.5	-5.5	3.1e-08	0.54	0.54	0.39	FALSE
23	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	-6.3	-6.7	2.5e-11	0.98	0.00	1.00	FALSE
24	GTEx	Cells Transformed fibroblasts	SLC50A1	0.08	0.07	lasso	6	0.07	3.9e-06	6.0	5.4	7.0e-08	-0.77	0.03	0.97	FALSE
25	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	-6.2	-6.3	3.5e-10	0.96	0.01	0.98	FALSE
26	GTEx	Colon Transverse	GBAP1	0.13	0.15	lasso	5	0.11	6.4e-06	-6.3	-6.7	1.7e-11	0.98	0.01	0.99	FALSE
27	GTEx	Colon Transverse	THBS3	0.11	0.09	lasso	4	0.09	5.9e-05	-6.3	5.7	1.0e-08	-0.95	0.01	0.98	FALSE
28	GTEx	Colon Transverse	GBA	0.06	0.09	enet	8	0.08	7.9e-05	4.6	-5.9	3.5e-09	0.86	0.02	0.97	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	-6.0	-6.4	1.4e-10	0.95	0.02	0.98	FALSE
30	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	-6.2	-6.7	2.4e-11	0.92	0.01	0.99	FALSE
31	GTEx	Esophagus Mucosa	THBS3	0.15	0.15	lasso	2	0.13	6.8e-09	-6.3	6.3	2.5e-10	-1.00	0.00	1.00	FALSE
32	GTEx	Esophagus Mucosa	GBA	0.28	0.30	enet	26	0.34	4.2e-23	4.5	-5.7	1.6e-08	0.72	0.89	0.11	FALSE
33	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	5.5	5.8	5.7e-09	-0.82	0.33	0.67	FALSE
34	GTEx	Esophagus Mucosa	RP11-263K19.4	0.14	0.14	lasso	4	0.12	1.5e-08	-6.3	6.3	2.4e-10	-0.99	0.01	0.99	FALSE
35	GTEx	Esophagus Muscularis	GBAP1	0.09	0.13	enet	4	0.12	8.9e-08	-5.8	-6.1	8.7e-10	0.97	0.01	0.99	FALSE
36	GTEx	Heart Left Ventricle	GBAP1	0.18	0.22	enet	13	0.18	1.1e-09	-5.8	-6.0	1.9e-09	0.93	0.03	0.97	FALSE
37	GTEx	Lung	GBAP1	0.16	0.16	lasso	5	0.15	1.6e-11	-5.8	-6.0	2.5e-09	0.95	0.02	0.98	FALSE
38	GTEx	Lung	FAM189B	0.09	0.05	lasso	4	0.05	1.4e-04	5.6	-5.5	5.1e-08	0.54	0.30	0.48	FALSE
39	GTEx	Lung	THBS3	0.11	0.07	lasso	4	0.04	1.0e-03	-6.3	6.2	7.0e-10	-0.98	0.01	0.99	FALSE
40	GTEx	Nerve Tibial	HCN3	0.17	0.28	lasso	6	0.25	5.8e-18	5.5	-5.5	3.3e-08	0.57	0.41	0.59	FALSE
41	GTEx	Nerve Tibial	GBAP1	0.12	0.14	lasso	1	0.14	8.9e-10	-6.2	-6.2	5.6e-10	0.99	0.01	0.99	FALSE
42	GTEx	Nerve Tibial	GBA	0.14	0.02	lasso	5	0.01	3.3e-02	-6.3	-6.2	4.0e-10	0.95	0.02	0.97	FALSE
43	GTEx	Pancreas	GBAP1	0.12	0.17	enet	10	0.14	2.4e-06	-5.8	-5.5	3.0e-08	0.91	0.02	0.98	FALSE
44	GTEx	Pancreas	GBA	0.12	0.05	enet	10	0.02	4.2e-02	-6.3	-5.8	9.1e-09	0.89	0.03	0.91	FALSE
45	GTEx	Prostate	GBAP1	0.47	0.30	lasso	7	0.32	1.1e-08	-6.3	-6.0	2.6e-09	0.95	0.01	0.99	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	5.5	-6.2	7.0e-10	0.90	0.02	0.96	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	FAM189B	0.09	0.00	enet	18	0.04	2.0e-03	5.4	-5.8	8.3e-09	0.62	0.07	0.88	FALSE
48	GTEx	Skin Sun Exposed Lower leg	RP11-263K19.4	0.04	0.01	enet	9	0.01	3.3e-02	-6.2	6.3	2.6e-10	-0.97	0.02	0.95	FALSE
49	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	6.1	-6.8	1.0e-11	0.93	0.02	0.89	FALSE
50	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	-6.0	-6.2	4.5e-10	0.87	0.02	0.98	FALSE
51	GTEx	Spleen	THBS3	0.23	0.10	enet	17	0.08	4.6e-03	3.8	5.2	1.6e-07	-0.80	0.02	0.91	FALSE
52	GTEx	Stomach	GBAP1	0.09	0.12	lasso	3	0.13	1.2e-06	-5.8	-6.3	3.7e-10	0.87	0.09	0.90	FALSE
53	GTEx	Testis	SCAMP3	0.09	0.01	lasso	5	0.02	5.1e-02	5.5	5.2	2.0e-07	-0.47	0.24	0.20	FALSE
54	GTEx	Testis	THBS3	0.11	0.11	lasso	2	0.09	1.2e-04	-5.8	5.9	3.2e-09	-0.95	0.01	0.98	FALSE
55	GTEx	Testis	RP11-263K19.4	0.08	0.12	lasso	2	0.10	2.4e-05	-5.8	5.8	5.4e-09	-0.94	0.02	0.97	FALSE
56	GTEx	Thyroid	DAP3	0.11	0.04	lasso	9	0.04	8.9e-04	5.5	-5.2	1.5e-07	0.59	0.06	0.87	FALSE
57	GTEx	Thyroid	HCN3	0.05	0.05	lasso	1	0.04	5.2e-04	5.4	-5.4	5.2e-08	0.55	0.24	0.21	FALSE
58	GTEx	Thyroid	GBAP1	0.23	0.28	lasso	10	0.27	4.6e-21	-6.4	-6.4	1.2e-10	0.99	0.00	1.00	FALSE
59	GTEx	Thyroid	FAM189B	0.08	0.10	lasso	2	0.11	5.3e-09	5.6	-5.6	2.0e-08	0.54	0.38	0.62	FALSE
60	GTEx	Thyroid	THBS3	0.12	0.09	enet	8	0.09	3.6e-07	-6.0	5.9	3.1e-09	-0.87	0.01	0.99	FALSE
61	GTEx	Thyroid	MSTO2P	0.05	0.05	lasso	5	0.04	6.2e-04	5.3	-5.1	3.0e-07	0.47	0.58	0.19	FALSE
62	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	3.8	-6.0	1.5e-09	0.86	0.03	0.90	FALSE
63	GTEx	Whole Blood	THBS3	0.17	0.20	enet	5	0.21	1.0e-18	-6.2	6.2	4.3e-10	-0.99	0.00	1.00	FALSE
64	GTEx	Whole Blood	RP11-263K19.4	0.15	0.17	lasso	4	0.17	9.5e-16	-6.2	6.2	6.3e-10	-0.98	0.01	0.99	FALSE
65	METSIM	Adipose	EFNA1	0.04	0.02	blup	350	0.02	8.5e-04	3.8	-6.4	1.8e-10	0.69	0.18	0.77	FALSE
66	METSIM	Adipose	THBS3	0.09	0.10	lasso	7	0.12	4.7e-17	-6.3	6.6	4.1e-11	-0.91	0.01	0.99	FALSE
67	NTR	Blood	THBS3	0.03	0.02	blup	341	0.02	2.8e-08	-6.4	6.0	1.9e-09	-0.77	0.01	0.99	FALSE
68	YFS	Blood	ADAM15	0.58	0.15	bslmm	373	0.40	3.7e-144	-4.7	-6.6	4.8e-11	0.44	0.97	0.03	TRUE
69	YFS	Blood	FAM189B	0.02	0.01	bslmm	312	0.02	3.2e-06	6.0	5.9	3.5e-09	-0.70	0.03	0.97	FALSE
70	YFS	Blood	SYT11	0.01	0.01	lasso	4	0.01	2.8e-05	5.2	-5.2	2.5e-07	0.42	0.02	0.98	FALSE
71	YFS	Blood	THBS3	0.29	0.22	enet	38	0.31	6.4e-105	-6.2	5.6	2.2e-08	-0.85	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	5.5	6.2	4.9e-10	-0.85	0.02	0.53	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBA	0.03	0.00	blup	26	0.02	3.1e-04	5.5	-6.6	5.1e-11	0.79	0.02	0.86	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAP1	0.02	0.03	lasso	4	0.03	1.3e-07	-6.3	-6.7	2.3e-11	0.90	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	MSTO2P	0.02	0.02	lasso	2	0.01	1.0e-03	5.3	-5.2	1.5e-07	0.46	0.00	0.97	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	THBS3	0.02	0.02	blup	26	0.02	4.0e-05	-6.4	6.8	1.4e-11	-0.93	0.00	0.99	FALSE
77	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GBAP1	0.10	0.06	enet	9	0.04	5.1e-03	-6.2	-6.1	1.3e-09	0.89	0.01	0.80	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	HCN3	0.08	0.00	lasso	3	0.00	5.7e-01	3.0	-5.2	2.1e-07	0.38	0.01	0.35	FALSE
79	The Cancer Genome Atlas	Esophageal Carcinoma	FAM189B	0.36	0.05	lasso	3	0.02	6.1e-02	-6.2	-6.2	5.7e-10	0.99	0.00	0.65	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	THBS3	0.04	0.01	blup	25	0.03	3.1e-04	6.1	6.0	2.3e-09	-0.80	0.01	0.89	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBA	0.04	0.01	blup	26	0.01	8.3e-03	5.7	-6.3	2.8e-10	0.71	0.02	0.43	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBAP1	0.04	0.04	blup	26	0.04	2.5e-05	6.0	-6.5	8.8e-11	0.85	0.01	0.98	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HCN3	0.03	0.03	lasso	1	0.03	2.3e-04	5.3	-5.3	1.4e-07	0.51	0.02	0.90	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THBS3	0.02	0.03	lasso	4	0.03	2.1e-04	-6.2	6.4	1.2e-10	-0.99	0.01	0.98	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	THBS3	0.04	0.02	enet	8	0.01	4.5e-02	6.0	6.7	2.1e-11	-0.76	0.01	0.66	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADAM15	0.07	0.00	enet	12	0.04	6.1e-05	4.2	-5.7	9.3e-09	0.31	0.03	0.15	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	6.0	-6.7	1.7e-11	0.92	0.01	0.95	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	4.4	6.1	9.2e-10	-0.82	0.03	0.97	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	GBAP1	0.02	0.03	enet	2	0.02	2.3e-03	-6.2	-6.2	4.5e-10	0.99	0.00	0.90	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	MSTO2P	0.05	0.03	lasso	3	0.03	4.9e-04	5.3	-5.3	1.4e-07	0.46	0.00	0.98	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBA	0.02	0.00	blup	27	0.01	1.2e-02	5.4	-6.3	2.8e-10	0.76	0.01	0.45	FALSE
92	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBAP1	0.04	0.02	blup	27	0.03	4.7e-04	-6.2	-6.3	3.6e-10	0.85	0.01	0.87	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	-6.2	-6.3	3.5e-10	0.91	0.01	0.88	FALSE
94	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM46	0.08	0.08	lasso	2	0.07	2.1e-05	-6.2	6.2	5.6e-10	-0.99	0.01	0.98	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	FDPS	0.02	0.02	lasso	2	0.01	1.6e-02	5.3	-5.4	8.0e-08	0.55	0.01	0.67	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	GBAP1	0.06	0.06	lasso	9	0.06	3.5e-07	6.0	-6.0	2.1e-09	0.80	0.01	0.99	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	THBS3	0.10	0.12	enet	11	0.10	4.4e-11	-6.4	6.0	1.6e-09	-0.98	0.00	1.00	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	-6.2	-6.9	6.9e-12	0.88	0.01	0.69	TRUE