Best TWAS P=1.31e-21 · Best GWAS P=7.3e-17 conditioned to 0.508
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CSE1L | 0.08 | 0.07 | bslmm | 503 | 0.05 | 1.7e-06 | -7.8 | -9.0 | 2.9e-19 | 0.91 | 0.03 | 0.97 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | DDX27 | 0.04 | 0.04 | enet | 11 | 0.07 | 7.3e-09 | -7.2 | 5.7 | 1.5e-08 | -0.82 | 0.03 | 0.97 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | STAU1 | 0.09 | 0.00 | bslmm | 500 | 0.01 | 8.7e-03 | -7.1 | -6.3 | 3.3e-10 | 0.51 | 0.05 | 0.82 | FALSE |
4 | GTEx | Adipose Subcutaneous | ARFGEF2 | 0.10 | 0.07 | lasso | 3 | 0.06 | 1.1e-05 | -8.3 | -8.2 | 3.4e-16 | 0.97 | 0.02 | 0.98 | FALSE |
5 | GTEx | Adipose Subcutaneous | CSE1L | 0.15 | 0.15 | lasso | 4 | 0.15 | 2.4e-12 | -8.1 | -8.1 | 8.5e-16 | 0.97 | 0.03 | 0.97 | FALSE |
6 | GTEx | Adipose Visceral Omentum | CSE1L | 0.13 | 0.02 | enet | 19 | 0.05 | 2.1e-03 | -7.7 | -5.7 | 1.2e-08 | 0.71 | 0.04 | 0.84 | FALSE |
7 | GTEx | Artery Aorta | CSE1L | 0.12 | 0.18 | lasso | 4 | 0.16 | 2.9e-09 | -7.8 | -7.4 | 1.1e-13 | 0.95 | 0.03 | 0.97 | FALSE |
8 | GTEx | Artery Tibial | CSE1L | 0.12 | 0.03 | lasso | 6 | 0.04 | 3.8e-04 | -8.2 | -9.0 | 2.3e-19 | 0.94 | 0.03 | 0.97 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | 7.8 | 7.9 | 2.2e-15 | -0.50 | 0.10 | 0.72 | FALSE |
10 | GTEx | Colon Sigmoid | ARFGEF2 | 0.15 | 0.12 | lasso | 1 | 0.07 | 2.3e-03 | 7.4 | -7.4 | 1.9e-13 | 0.69 | 0.09 | 0.36 | FALSE |
11 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | 8.3 | -8.3 | 8.5e-17 | 0.56 | 0.03 | 0.96 | FALSE |
12 | GTEx | Colon Transverse | ARFGEF2 | 0.11 | 0.07 | enet | 12 | 0.09 | 2.9e-05 | -8.2 | -8.9 | 8.2e-19 | 0.88 | 0.03 | 0.95 | FALSE |
13 | GTEx | Colon Transverse | CSE1L | 0.17 | 0.01 | enet | 19 | 0.03 | 1.2e-02 | 6.7 | -7.3 | 3.2e-13 | 0.56 | 0.14 | 0.38 | FALSE |
14 | GTEx | Esophagus Gastroesophageal Junction | CSE1L | 0.17 | 0.07 | lasso | 5 | 0.07 | 1.6e-03 | -8.2 | -8.1 | 4.5e-16 | 0.90 | 0.04 | 0.90 | FALSE |
15 | GTEx | Esophagus Mucosa | CSE1L | 0.09 | 0.06 | lasso | 4 | 0.06 | 6.9e-05 | 7.9 | -8.6 | 6.8e-18 | 0.70 | 0.05 | 0.93 | FALSE |
16 | GTEx | Esophagus Muscularis | CSE1L | 0.16 | 0.14 | enet | 22 | 0.12 | 5.1e-08 | -8.2 | -7.8 | 6.7e-15 | 0.91 | 0.02 | 0.98 | FALSE |
17 | GTEx | Heart Atrial Appendage | CSE1L | 0.09 | 0.07 | lasso | 5 | 0.06 | 9.1e-04 | -8.2 | -7.7 | 1.9e-14 | 0.97 | 0.03 | 0.96 | FALSE |
18 | GTEx | Lung | CSE1L | 0.10 | 0.09 | lasso | 5 | 0.08 | 6.6e-07 | 7.9 | -8.7 | 2.8e-18 | 0.61 | 0.06 | 0.94 | FALSE |
19 | GTEx | Muscle Skeletal | PREX1 | 0.14 | 0.09 | enet | 23 | 0.13 | 2.5e-12 | 7.2 | 6.5 | 8.5e-11 | -0.20 | 0.98 | 0.02 | TRUE |
20 | GTEx | Muscle Skeletal | CSE1L | 0.18 | 0.19 | lasso | 9 | 0.20 | 4.6e-19 | -8.3 | -7.4 | 1.4e-13 | 0.97 | 0.02 | 0.98 | FALSE |
21 | GTEx | Nerve Tibial | CSE1L | 0.12 | 0.01 | lasso | 10 | 0.03 | 5.7e-03 | -8.2 | -8.5 | 2.5e-17 | 0.85 | 0.04 | 0.84 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | CSE1L | 0.08 | 0.03 | lasso | 2 | 0.03 | 9.5e-04 | 7.9 | -8.5 | 1.6e-17 | 0.66 | 0.05 | 0.91 | FALSE |
23 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 7.8 | -7.8 | 4.6e-15 | 0.49 | 0.08 | 0.92 | FALSE |
24 | GTEx | Thyroid | CSE1L | 0.20 | 0.21 | enet | 15 | 0.20 | 2.3e-15 | -7.8 | -8.2 | 3.0e-16 | 0.99 | 0.03 | 0.97 | FALSE |
25 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 6.8 | -6.7 | 2.1e-11 | 0.44 | 0.13 | 0.85 | FALSE |
26 | METSIM | Adipose | CSE1L | 0.05 | 0.05 | lasso | 4 | 0.04 | 5.3e-07 | -8.2 | -8.7 | 2.5e-18 | 0.98 | 0.03 | 0.97 | FALSE |
27 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 6.2 | -6.7 | 2.1e-11 | 0.46 | 1.00 | 0.00 | FALSE |
28 | ROSMAP | Brain Pre-frontal Cortex | CSE1L | 0.04 | 0.02 | enet | 16 | 0.02 | 2.8e-03 | 7.4 | -8.3 | 7.3e-17 | 0.80 | 0.07 | 0.92 | FALSE |
29 | YFS | Blood | CSE1L | 0.06 | 0.05 | enet | 21 | 0.06 | 2.0e-19 | -8.2 | -9.6 | 1.3e-21 | 0.87 | 0.02 | 0.98 | TRUE |
30 | The Cancer Genome Atlas | Glioblastoma Multiforme | CSE1L | 0.15 | 0.06 | lasso | 3 | 0.07 | 4.4e-03 | -8.1 | -8.2 | 2.9e-16 | 0.97 | 0.01 | 0.56 | FALSE |
31 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CSE1L | 0.03 | 0.05 | lasso | 1 | 0.03 | 9.3e-05 | 7.8 | -7.8 | 5.9e-15 | 0.49 | 0.03 | 0.96 | FALSE |
32 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CSE1L | 0.05 | 0.07 | blup | 50 | 0.07 | 3.2e-08 | 8.3 | -9.0 | 1.7e-19 | 0.70 | 0.02 | 0.98 | FALSE |
33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 6.9 | -7.7 | 1.7e-14 | 0.48 | 0.12 | 0.87 | FALSE |
34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CSE1L | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.0e-06 | -8.1 | -8.3 | 1.1e-16 | 0.98 | 0.02 | 0.98 | FALSE |
35 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 6.2 | 6.2 | 6.5e-10 | -0.42 | 0.10 | 0.33 | FALSE |
36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSE1L | 0.05 | 0.05 | lasso | 3 | 0.06 | 8.1e-07 | -7.8 | -7.9 | 2.1e-15 | 0.98 | 0.02 | 0.98 | FALSE |
37 | The Cancer Genome Atlas | Thyroid Carcinoma | CSE1L | 0.12 | 0.20 | lasso | 2 | 0.19 | 7.1e-18 | -8.3 | -8.2 | 1.6e-16 | 0.99 | 0.01 | 0.99 | FALSE |
38 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX27 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.9e-05 | 6.2 | 7.7 | 1.5e-14 | -0.70 | 0.26 | 0.54 | FALSE |