TWAS hub - PREX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3240	0.0800	2.2e-07	0.081	NA	0.132	NA	0.138	3.0e-05	NA	9.6e-08	NA	4.9e-08
2	GTEx	Artery Tibial	0.2990	0.0517	1.0e-11	0.101	NA	0.193	NA	0.191	2.7e-08	NA	5.0e-15	NA	6.8e-15
3	GTEx	Muscle Skeletal	0.1431	0.0347	2.2e-08	0.092	NA	0.126	NA	0.103	2.8e-09	NA	2.5e-12	NA	2.9e-10
4	ROSMAP	Brain Pre-frontal Cortex	0.0897	0.0256	1.8e-05	0.015	0.052	0.049	0.057	0.050	4.7e-03	2.5e-07	5.4e-07	8.4e-08	4.4e-07
5	TCGA	Lung Adenocarcinoma	0.0431	0.0248	5.5e-03	-0.001	0.003	-0.002	NA	-0.002	4.8e-01	1.3e-01	9.2e-01	NA	6.5e-01
6	TCGA	Prostate Adenocarcinoma	0.1946	0.0491	0.0e+00	0.204	0.203	0.212	NA	0.220	6.3e-21	6.9e-21	8.6e-22	NA	1.0e-22

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Mouth/teeth dental problems: Mouth ulcers	6.6	10.6	20.3	-4.2	-3.4	3.7	0.4	-0.2	-4.5
Ever highly irritable/argumentative for 2 days	5.7	6.9	13.7	-0.6	-2.2	2.5	3.3	3.7	-2.2
Frequency of tiredness / lethargy in last 2 weeks	4.9	7.9	15.8	-3.9	-2.3	3.4	0.5	0.2	-4.0
Frequency of unenthusiasm / disinterest in last 2 weeks	4.8	6.4	12.7	-3.6	-2.6	2.7	-0.0	0.2	-3.4
Diastolic blood pressure, automated reading	4.4	13.7	35.6	-5.5	-2.6	-2.7	-0.7	-1.1	-6.0
Happiness	3.7	4.5	9.5	-0.9	-1.7	3.1	2.6	1.6	-2.1
Birth weight of first child	3.5	6.3	26.0	-1.8	-2.1	5.1	0.8	1.5	-1.3
Heart attack/myocardial infarction (self-reported)	3.5	4.5	8.6	2.9	2.2	-2.9	0.2	0.7	2.0
Average weekly spirits intake	3.4	4.2	10.5	-3.2	-1.1	1.8	-1.4	-2.0	-2.1
Heart attack	3.4	4.4	9.7	2.9	1.9	-3.1	0.3	0.7	2.0
Chronotype (morning person)	3.3	7.6	14.3	-2.1	-2.9	1.6	3.3	2.2	-3.8
Prospective memory result	3.2	4.0	8.8	3.0	2.1	-2.6	1.0	0.6	1.7
Miserableness	3.2	5.5	11.8	-3.4	-1.7	2.7	-1.2	-1.1	-2.9
Frequency of depressed mood in last 2 weeks	3.1	4.4	10.9	-2.5	-0.9	3.3	1.1	0.1	-2.7
Vitamin and mineral supplements	3.0	4.1	7.8	2.7	1.4	-2.8	0.7	1.3	2.3
Average weekly beer plus cider intake	2.9	4.2	10.3	-2.2	0.2	-0.5	-3.2	-3.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.4	7.0	-2.4	-2.5	2.5	1.0	0.7	-2.6
Depression (Nagel 2018)	2.7	4.0	7.1	-2.3	-1.8	2.3	1.6	0.8	-2.7
Intelligence (Savage-Jansen 2018)	2.7	8.4	42.1	-1.6	-0.7	6.5	1.5	0.6	-1.5
Ever had bowel cancer screening	2.7	3.2	8.7	2.3	3.0	-1.4	1.1	0.1	1.4
Ever unenthusiastic/disinterested for a whole week	2.6	3.1	5.4	-2.3	-0.4	2.0	-2.0	-1.8	-1.4
Birth weight	2.6	5.7	20.2	0.2	-2.8	4.5	1.2	2.1	0.6
Ever depressed for a whole week	2.6	3.2	6.6	-2.6	-0.5	2.4	-1.0	-1.2	-2.2
Rheumatoid Arthritis	2.5	3.4	11.1	-2.1	-3.3	0.0	0.4	0.2	-2.1
Hearing difficulty/problems: Yes	2.5	3.9	9.3	2.7	-0.4	0.4	1.6	3.0	2.0
Peak expiratory flow (PEF)	2.5	5.8	17.2	-2.7	-1.7	4.1	0.4	0.4	-2.8
Hearing aid user	2.5	2.8	8.7	1.5	-1.2	0.9	1.7	3.0	0.8
Number of incorrect matches in round	2.4	4.0	20.8	1.3	0.9	-4.6	-0.2	-0.2	0.9
Qualifications: nursing, teaching	2.3	3.6	8.7	2.1	2.9	1.0	-1.1	-0.8	2.3
Type 2 Diabetes (T2D) (2012)	2.2	2.5	3.8	-1.8	-1.4	1.8	-2.0	-1.7	-0.0
Forced vital capacity (FVC)	2.2	8.3	38.1	-1.1	-0.9	6.2	1.5	2.5	-1.2
Forced vital capacity (FVC), Best measure	2.2	8.0	37.7	-1.4	-0.5	6.1	1.2	2.3	-1.1
Family relationship satisfaction	2.2	2.7	8.9	-1.4	-1.2	3.0	0.7	0.7	-1.8
Alzheimer’s Disease (in father)	2.0	2.1	5.6	-0.1	-1.1	2.4	1.7	1.8	-0.4
Verbal and Numeric Reasoning (VNR)	2.0	4.8	23.2	-1.1	-0.9	4.8	1.2	1.0	-1.1
Coronary Artery Disease (CAD)	2.0	2.4	8.2	1.7	0.6	-2.9	-0.6	-0.4	1.7
Systolic Blood Pressure	2.0	9.9	46.0	-0.8	1.6	-6.8	-1.4	-2.5	-1.4
Hearing difficulty/problems with background noise	2.0	3.3	6.3	-0.0	-2.1	2.5	1.6	2.5	-0.4
Medication: Lansoprazole	2.0	2.3	4.9	-1.9	-2.2	0.3	0.7	-0.2	-2.2
Supplements: Vitamin C	2.0	2.4	9.6	-0.8	-0.7	3.1	1.2	0.7	-1.3
Commuting to job workplace: Walk	2.0	2.2	5.1	1.1	-1.5	0.4	2.1	2.3	-0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.7	2.2	1.7	-0.9	0.7	0.5	2.1
Maternal smoking around birth	1.8	2.6	8.4	-2.2	-1.3	0.6	0.6	0.6	-2.9
High blood pressure (mother)	1.8	2.6	10.3	1.4	-0.3	-3.2	1.6	0.7	0.1
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	6.3	0.6	-1.8	-0.7	1.9	2.5	-0.1
Back pain experienced in last month	1.8	2.6	5.0	-0.7	-1.9	1.1	1.9	2.2	-1.3
Schizophrenia vs Biploar Disorder	1.7	2.3	4.8	0.4	2.1	1.3	-2.2	-1.0	1.3
Relative age voice broke	1.7	2.5	4.6	-2.1	0.0	1.6	-1.5	-2.1	-1.1
Illnesses of father: High blood pressure	1.7	2.0	5.1	-0.4	0.8	-1.8	-2.2	-1.8	0.3
Reaction Time	1.6	3.0	8.1	-1.0	-1.7	2.8	1.3	1.3	-1.6
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.3	-1.5	-2.1	1.3	-0.0	0.4	-1.4
Neuroticism score	1.6	3.3	7.6	-2.0	-2.8	2.1	0.6	0.7	-1.8
Exposure to tobacco smoke outside home	1.6	2.1	4.1	-2.0	-1.7	1.6	-0.6	-0.6	-1.6
Comparative height size at age 10	1.6	8.9	33.2	-0.5	-1.8	5.8	1.9	3.6	-0.5
Loneliness, isolation	1.6	2.2	6.1	-0.5	-1.4	2.5	1.4	1.7	-0.3
Age started oral contraceptive pill	1.6	2.0	4.3	0.2	-1.5	1.4	2.1	1.7	-0.5
Bipolar Disorder (2011)	1.5	1.4	2.7	1.4	-0.9	-1.6	1.2	1.3	0.2
Father’s age at death	1.5	2.0	4.0	2.0	0.5	-0.9	2.0	1.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.6	19.7	-1.2	-0.6	4.4	1.1	2.0	-1.2
Pulse wave reflection index	1.5	1.8	3.6	-1.9	-0.5	0.8	-1.2	-1.7	-1.5
Mean time to correctly identify matches	1.5	2.9	7.4	-1.0	-1.6	2.7	1.4	1.2	-1.8
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.2	-1.8	0.6	-1.0	-1.2	-1.4	-1.6
Friendships satisfaction	1.5	1.8	3.1	-0.6	-0.9	1.0	1.8	1.8	-1.6
Breast cancer (self-reported)	1.5	1.8	4.9	0.1	-0.7	1.5	1.7	2.2	-0.6
Mother’s age at death	1.5	1.8	4.9	2.2	0.1	-1.1	1.6	0.8	1.3
Irritability	1.5	2.5	4.7	-1.6	-1.3	2.2	1.1	1.2	-1.8
LDL Cholesterol	1.4	2.3	4.7	-2.1	-1.3	2.2	-0.2	0.3	-1.7
Systolic blood pressure, automated reading	1.4	4.0	17.6	-1.2	0.3	-4.2	-1.1	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	20.2	-1.4	-0.7	4.5	1.0	1.6	-1.6
Standing height	1.4	13.6	68.1	0.6	0.3	8.2	1.4	3.1	1.3
Age at last live birth	1.4	2.0	4.2	1.2	2.0	0.1	-1.5	-0.3	2.0
Alzheimer’s Disease (including proxy)	1.3	1.9	3.4	-0.0	-1.3	1.7	1.6	1.9	-0.7
Crohns Disease (2017)	1.3	2.8	5.1	2.0	-0.1	-1.9	1.7	2.2	1.0
Ovarian Cancer	1.3	1.8	5.7	0.5	2.4	1.0	-1.3	-0.8	1.2
Body Mass Index (BMI) (2010)	1.3	1.8	4.4	0.4	0.6	-2.1	-1.6	-1.3	1.1
Height	1.3	25.3	144.0	0.3	0.6	12.0	0.2	2.3	1.6
Glaucoma (self-reported)	1.3	1.5	3.6	-0.4	0.2	-1.3	-1.9	-1.7	0.6
Medication: Ventolin 100micrograms inhaler	1.3	1.7	5.6	-1.3	-2.4	0.5	0.6	0.3	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.5	-0.3	1.6	0.3	-1.9	-1.8	0.2
Wears glasses or contact lenses	1.3	1.5	2.3	1.5	-0.5	-1.3	1.4	0.9	1.3
Myopia	1.3	1.9	9.5	0.5	0.5	-3.1	0.9	-0.1	-0.8
Schizophrenia (2018)	1.2	2.6	5.6	2.4	2.1	-0.0	-0.4	0.0	2.3
Blood Red Count	1.2	11.5	24.5	1.4	-3.7	4.3	3.1	5.0	0.9
Cardiovascular Disease	1.2	4.0	6.3	-2.2	0.8	-2.1	-1.4	-2.5	-2.4
Neuroticism	1.2	2.8	5.9	-2.2	-1.5	2.4	0.1	-0.1	-1.9
Relative age of first facial hair	1.2	2.4	4.0	-2.0	-0.9	1.7	-1.3	-2.0	-1.1
High blood pressure	1.2	3.3	9.3	-1.9	-0.2	-3.1	-0.7	-1.3	-2.1
Alcohol intake versus 10 years previously	1.2	1.8	4.1	-1.4	0.5	-0.6	-1.8	-2.0	-0.8
Medication: Cholesterol lowering	1.2	1.9	4.7	1.6	1.6	-2.2	0.8	0.5	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.4	-1.5	-1.1	2.1	-0.8	-1.2	-0.8
Headache pain in last month	1.2	2.1	3.1	-1.1	-1.8	1.6	1.1	1.3	-1.6
Qualifications: College or University degree	1.2	3.9	7.5	1.8	1.0	2.3	2.7	2.4	0.9
Medication for cholesterol	1.2	1.9	4.3	0.6	-1.2	2.1	0.7	1.8	1.3
Medication: Lisinopril	1.2	1.6	4.3	-1.3	-0.1	-1.5	1.0	-0.3	-2.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.3	-0.2	-0.9	-0.3	1.8	1.5	-1.4
Crohns Disease (2012)	1.1	1.8	4.4	1.5	-0.6	-1.3	1.5	2.1	0.4
Lupus	1.1	1.6	4.4	-2.1	-0.4	1.4	-0.9	-1.1	-1.1
Respiratory disease	1.1	2.4	7.2	-0.7	-2.2	2.7	0.7	1.0	-0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.5	3.3	1.6	1.2	-0.6	-0.5	-0.8	1.8
Sitting height	1.1	7.9	31.0	1.3	0.2	5.6	1.7	3.0	1.6
Nervous feelings	1.1	2.1	4.1	-1.4	-2.0	1.8	0.5	0.6	-1.6
Noisy workplace	1.1	1.3	2.1	-1.4	-0.5	1.4	-1.4	-0.5	-1.1
Qualifications: A levels/AS levels or equivalent	1.1	2.4	12.9	-0.3	-0.4	3.6	0.9	0.5	0.2
Asthma	1.1	2.2	5.8	-1.1	-2.2	2.4	0.6	0.3	-1.0
Exposure to tobacco smoke at home	1.1	1.3	3.0	-1.6	-0.3	-0.9	-0.3	-1.0	-1.7
High blood pressure (siblings)	1.1	1.7	5.1	-1.4	-1.3	-1.0	0.1	-0.2	-2.2
Eye problems/disorders: None of the above	1.1	1.2	3.4	-1.9	-0.6	0.5	-0.2	-0.4	-1.8
Hypertension (Self-reported)	1.1	3.0	8.0	-1.8	-0.1	-2.8	-0.9	-1.2	-2.1
Asthma (self-reported)	1.1	2.1	5.1	-1.2	-2.1	2.3	0.6	0.3	-1.1
Illnesses of father: None of the above (group 1)	1.1	1.4	3.5	-1.0	-0.5	0.7	1.4	1.0	-1.9
Number of self-reported non-cancer illnesses	1.1	1.9	3.0	-1.5	0.0	-1.7	-1.4	-1.5	-1.3
Bipolar Disorder or Schizophrenia	1.0	2.3	6.7	2.6	1.1	-1.0	0.8	0.7	2.0
Ulcerative Colitis (UC)	1.0	1.8	4.1	-2.0	-0.8	0.8	-1.4	-1.2	-1.5
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.5	-1.1	-1.7	-1.9	0.9	0.6	-1.6
Diabetes (father)	1.0	1.2	2.5	0.7	-1.6	-1.3	0.7	1.2	0.7
Arm fat percentage (right)	1.0	3.8	18.5	-0.5	-1.2	-4.3	-0.4	-1.5	-0.3
Loud music exposure frequency	1.0	1.1	2.0	-1.1	-1.4	1.0	-1.0	-0.8	-0.7
Number of children fathered	1.0	1.1	3.6	1.3	0.3	-1.9	0.2	0.5	0.8
Medication: Omeprazole	1.0	1.2	2.6	-0.0	-0.7	-0.5	1.6	1.6	-1.2
Leg pain on walking	1.0	1.2	2.4	-0.6	-1.5	0.9	1.1	1.2	-1.1
Mood swings	1.0	1.8	5.4	-2.3	-0.8	0.3	-1.1	-1.1	-1.5
Financial situation satisfaction	1.0	1.2	2.3	-1.4	-0.3	1.2	-0.6	-1.1	-1.5
Bipolar Disorder (2018)	0.9	1.5	3.0	1.2	-0.8	-1.6	1.7	1.0	0.4
Angina	0.9	1.2	3.6	1.3	0.5	-1.9	-0.4	0.6	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.0	-1.9	-2.2	1.4	-0.6	-0.9	-0.8
Fluid intelligence score	0.9	1.9	9.4	0.4	-0.5	3.1	0.9	0.8	0.6
Illnesses of mother	0.9	1.1	2.1	-0.3	0.5	1.4	-1.5	-1.1	0.8
Leg fat percentage (right)	0.9	3.2	17.7	0.1	-0.7	-4.2	-0.2	-1.1	0.0
Worry too long after embarrassment	0.9	1.6	4.4	-1.4	-2.1	1.2	0.2	0.2	-1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	4.4	0.9	1.3	2.1	0.1	0.1	1.3
Medication: Blood pressure	0.9	1.6	5.5	0.0	1.6	-2.3	-0.6	-1.1	0.2
Arm fat percentage (left)	0.9	3.7	18.6	-0.5	-1.1	-4.3	-0.3	-1.4	-0.3
Diabetes diagnosed by doctor	0.9	1.5	4.0	-1.4	-0.6	-1.5	0.6	-0.2	-2.0
Smoking status: Current	0.9	1.4	5.4	1.0	0.9	-2.3	1.2	0.4	-0.0
Medication: Blood pressure	0.9	1.7	6.9	-0.5	0.3	-2.6	0.5	-0.7	-1.5
Leg fat percentage (left)	0.9	3.3	17.6	-0.1	-0.6	-4.2	-0.2	-1.2	-0.3
Fractured/broken bones in last 5 years	0.9	1.2	4.0	-1.2	-0.3	-1.0	0.1	-0.8	-2.0
Vascular/heart problems diagnosed by doctor	0.9	2.5	9.8	1.1	-0.2	3.1	0.9	1.2	1.4
Supplements: Calcium	0.9	1.0	3.4	0.5	-0.7	1.8	0.0	0.9	0.9
Depressed Affect (Nagel 2018)	0.8	1.7	4.3	-2.1	-1.1	1.4	0.0	-0.2	-1.7
Blood White Count	0.8	6.3	15.4	3.4	1.6	-1.8	-1.6	-1.7	3.9
Lung FVC	0.8	3.9	10.8	-2.4	-0.0	3.3	0.7	0.6	-2.5
Medication: Metformin	0.8	1.1	4.1	1.1	0.1	-2.0	0.7	0.8	0.5
Fed-up feelings	0.8	1.4	3.1	-0.8	-1.8	1.0	1.2	1.1	-1.0
Serious illness, injury or assault to yourself	0.8	1.0	2.7	-0.1	1.6	0.2	-0.9	-1.5	0.1
Stomach or abdominal pain in last month	0.8	1.0	2.8	0.9	1.2	-1.7	0.6	0.5	0.2
Supplements: Glucosamine	0.8	1.0	2.7	0.3	0.5	-1.1	-1.6	-0.8	1.0
Wheeze or whistling in the chest in last year	0.8	1.5	4.5	-0.2	-2.1	-1.2	0.9	1.1	-1.0
Pulse wave peak to peak time	0.8	0.9	1.8	1.3	-0.2	-0.6	0.7	1.1	1.3
Health satisfaction	0.8	1.1	3.9	-0.9	-0.6	-0.2	1.1	0.4	-2.0
Shortness of breath walking on level ground	0.8	0.9	2.3	-1.0	-0.9	-0.7	0.8	0.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.9	-2.0	-0.1	0.9	-0.4	-0.7	-2.2
Guilty feelings	0.8	1.2	2.5	0.2	-1.4	-0.8	1.6	1.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.8	0.9	1.9	-0.3	-1.4	-1.1	0.7	1.2	-0.8
Pain experienced in last month	0.8	1.4	4.3	-0.5	1.4	-0.7	-1.0	-2.1	-0.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	0.1	-0.8	0.4	1.2	1.2	-0.8
Fasting Glucose	0.7	0.8	1.7	-1.2	-0.0	-0.5	-0.7	-1.0	-1.3
Schizophrenia (2014)	0.7	1.5	3.2	1.7	1.7	-0.1	-0.7	-0.2	1.8
Medication for hormone replacement therapy	0.7	0.8	1.6	0.9	1.3	-0.6	-0.9	-0.8	0.8
Hand grip strength (right)	0.7	1.9	7.3	0.3	1.6	2.7	-0.0	0.9	0.5
Current tobacco smoking	0.7	1.1	4.0	0.9	0.9	-2.0	1.1	0.4	0.1
Average weekly fortified wine intake	0.7	0.9	3.1	-0.5	1.7	-0.6	-0.5	-0.4	-1.1
Multivitamins +/- minerals	0.7	0.9	2.9	-0.9	-0.5	0.5	-1.7	-1.0	-0.0
Hair/balding pattern: Pattern 2	0.7	0.8	1.6	1.2	-0.7	0.3	0.6	1.3	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	0.8	1.5	0.6	-0.5	-0.5	1.0
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-1.2	0.2	1.0	-0.5	-0.9	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	5.9	0.0	-0.4	2.4	0.3	-0.0	0.4
Blood clot in the leg (DVT)	0.7	0.9	2.9	1.7	1.3	-0.2	0.2	0.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	5.6	-0.4	-1.1	2.4	-0.4	0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.2	-0.3	1.2	-1.2	-1.0	-2.1	-0.3
Medication: Amlodipine	0.7	1.0	3.1	0.2	1.7	-1.6	-0.1	-0.5	-0.1
Body fat percentage	0.7	2.7	13.7	-0.1	-0.8	-3.7	-0.5	-1.2	0.2
Neck or shoulder pain in last month	0.7	1.0	2.6	1.0	-0.8	1.0	0.7	1.6	0.6
Angina (self-reported)	0.7	0.9	2.9	1.1	0.2	-1.7	-0.2	0.8	0.8
Suffer from ‘nerves’	0.7	1.2	4.6	-0.4	-1.4	2.1	0.3	0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-0.6	0.7	-0.5	-1.4	-1.3	0.3
Knee pain experienced in last month	0.7	1.1	1.8	1.1	-0.5	-1.3	0.6	1.4	1.0
Smoking status: Previous	0.7	1.1	5.3	-0.6	-0.6	2.3	0.5	0.3	-0.6
Average weekly champagne plus white wine intake	0.7	1.0	5.2	0.7	0.3	-2.3	0.2	0.1	0.4
Neuroticism (2016)	0.6	0.8	2.2	-0.9	-0.7	0.7	0.8	0.5	-1.5
Ulcerative Colitis	0.6	0.9	3.1	-0.7	-0.0	-0.2	-1.8	-1.2	0.1
Hand grip strength (left)	0.6	1.7	7.6	0.3	0.7	2.8	0.1	1.2	0.7
Number of treatments/medications taken	0.6	1.1	5.0	0.1	0.3	-2.2	-0.6	-1.0	-0.1
Medication: Co-codamol	0.6	0.7	1.6	1.3	1.0	-0.4	1.1	0.6	0.4
Age when periods started (menarche)	0.6	1.4	3.6	1.9	0.8	-0.5	0.1	0.7	1.9
Qualifications: CSEs or equivalent	0.6	0.8	1.6	-1.2	-0.7	0.8	-1.3	-0.8	-0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	0.4	-1.2	-1.1	1.0	0.4	0.0
Medication: Atenolol	0.6	0.7	2.0	-0.7	0.4	-1.2	-0.0	-0.4	-1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	3.2	-0.8	-1.8	-0.3	-0.5	-0.5	-0.2
Body mass index (BMI)	0.6	2.5	13.5	0.1	-0.4	-3.7	-0.3	-1.2	-0.0
Had menopause	0.6	0.8	1.6	-0.3	-1.3	0.9	1.2	0.6	-0.5
Qualifications: None of the above	0.6	1.3	6.5	-0.3	-0.6	-2.6	-0.9	-0.1	-0.2
Pain all over the body in last month	0.6	0.6	1.1	-1.0	-0.1	1.0	-0.6	-0.9	-0.6
Number of live births	0.6	0.8	2.4	0.7	-0.4	-1.6	0.8	0.8	0.5
Mouth/teeth dental problems: Dentures	0.6	1.0	3.0	1.7	0.2	-0.7	0.2	0.7	1.4
Depression (self-reported)	0.6	0.7	1.4	-0.3	0.7	1.2	-1.0	-1.1	0.4
Length of working week for main job	0.6	0.6	1.5	1.2	-0.2	-1.0	0.1	0.5	1.0
Tense / ‘highly strung’	0.6	1.0	2.9	-0.8	-0.1	1.7	0.7	0.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.1	-0.6	0.2	1.5	-1.2	-0.6	0.2
Age at first live birth	0.6	1.1	3.1	1.1	1.3	-0.5	-0.8	-0.0	1.8
Medication: Ibuprofen	0.6	0.7	2.2	0.2	-1.5	-0.6	0.6	1.1	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-0.9	-0.8	1.0	0.2	-1.0	-0.7
Illnesses of father: Heart disease	0.6	0.9	2.4	1.5	0.9	-0.3	-0.2	-0.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.7	0.2	0.3	2.2	0.7	1.3	0.6
Average weekly red wine intake	0.6	0.9	1.9	-0.0	-0.8	1.1	1.4	1.0	-0.6
Osteoporosis (self-reported)	0.6	0.7	2.8	-0.2	-0.8	-0.3	1.7	0.6	-0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	-0.1	-0.5	-1.3	-1.1	-0.9	0.7
Medication: Bendroflumethiazide	0.6	0.9	3.0	0.3	1.2	-1.7	0.4	-0.7	-0.4
Ever smoked	0.6	1.0	2.8	-0.8	-0.3	1.0	1.1	0.5	-1.7
Risk taking	0.6	0.9	1.8	-1.4	0.1	-0.3	-1.2	-1.3	-0.6
Unable to work because of sickness or disability	0.6	0.7	2.3	-0.5	0.7	0.8	0.5	0.6	-1.5
Commuting to job workplace: Cycle	0.6	0.7	1.3	-0.7	-0.1	1.1	-1.1	-1.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.4	1.5	1.4	-0.2	-0.1	-0.1	0.8
Neuroticism (Nagel 2018)	0.5	1.3	2.0	-1.1	-1.4	0.9	1.1	0.7	-1.3
Worry (Nagel 2018)	0.5	1.0	2.5	-1.0	-1.2	1.6	0.6	0.1	-1.0
Allergy or Eczema	0.5	1.3	2.8	1.1	0.6	1.6	0.7	1.7	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	-0.7	-0.9	0.7	0.5	0.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.6	0.5	-0.3	-0.2	1.2	1.1	-0.5
Supplements: Zinc	0.5	0.5	2.7	0.1	0.6	1.6	-0.4	0.0	0.2
Pack years adult smoking proportion	0.5	0.8	2.1	-0.8	-1.4	0.5	0.0	1.0	-0.8
Trunk fat percentage	0.5	1.9	8.3	-0.2	-1.0	-2.9	-0.5	-1.2	0.4
Medication: Levothyroxine sodium	0.5	0.9	2.4	-1.3	-0.5	1.0	-0.1	-0.3	-1.5
Past tobacco smoking	0.5	0.9	1.9	0.7	0.2	-1.4	-1.0	-0.3	1.2
Alcohol usually taken with meals	0.5	0.7	2.7	0.9	1.6	-0.6	0.7	-0.2	0.3
Financial difficulties in last 2 years	0.5	0.6	2.2	-0.8	-0.3	1.5	-0.7	-0.5	-0.1
Diabetes (self-reported)	0.5	0.8	1.7	-0.8	-0.8	-1.1	0.6	0.5	-1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	1.2	0.6	-0.5	-0.3	0.3	1.3
Trunk fat-free mass	0.5	2.9	13.0	0.7	0.5	3.6	0.9	1.5	0.7
Pulse rate	0.5	0.9	1.5	-0.3	-0.3	0.8	1.2	1.2	-1.2
Trunk predicted mass	0.5	2.9	12.7	0.7	0.5	3.6	1.0	1.6	0.7
Breastfed as a baby	0.5	0.6	0.8	0.9	-0.5	0.9	0.5	0.9	0.9
Hair/balding pattern: Pattern 4	0.5	1.2	4.9	-0.3	0.7	-2.2	0.3	-0.6	-1.2
Medication: Paracetamol	0.5	0.8	3.7	0.6	-0.5	-1.9	-0.3	-0.3	0.4
Gout (self-reported)	0.5	0.7	1.5	0.0	-0.5	1.1	-0.9	-0.3	1.2
Comparative body size at age 10	0.5	1.5	6.3	0.1	-2.5	0.2	1.0	1.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	0.4	0.6	-1.0	-1.0	-1.0	0.5
Migraine (self-reported)	0.5	0.6	1.4	1.2	0.1	-0.2	-0.0	0.9	1.1
Medication: Allopurinol	0.5	0.7	2.3	0.8	0.6	0.6	-0.7	-0.2	1.5
Osteoarthritis (self-reported)	0.5	0.7	2.9	0.2	0.3	-0.2	-1.7	-0.7	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.3	-0.3	-0.6	0.5	-1.5	-0.1	0.8
Commuting to job workplace: Public transport	0.5	0.6	2.4	0.5	-0.0	1.5	1.0	0.2	0.2
Medication: Paracetamol	0.5	0.8	2.4	0.9	-0.8	-1.5	0.3	0.6	0.5
Heart disease (siblings)	0.5	0.6	1.7	1.3	0.4	0.5	0.6	0.9	0.6
Primary Biliary Cirrhosis	0.4	0.5	1.5	-0.0	-0.1	-0.6	-1.2	-0.6	1.0
Triglycerides	0.4	0.6	1.4	0.3	-0.5	-1.0	1.2	0.7	-0.7
Blood Platelet Count	0.4	4.3	9.8	-1.1	-1.5	2.5	-3.1	-2.1	1.4
BMI	0.4	2.5	10.9	0.5	-0.5	-3.3	-0.9	-1.5	0.7
Hypothyroidism (self reported)	0.4	0.9	3.0	-0.4	1.0	-0.9	-0.6	-1.7	-0.6
Lung FEV1/FVC ratio	0.4	2.1	8.7	-0.1	1.1	-3.0	0.4	-0.5	-1.5
Diabetes (mother)	0.4	0.5	1.3	-0.1	-0.8	-0.4	1.2	0.8	-0.7
Severe depression (siblings)	0.4	0.4	1.3	0.9	0.0	0.3	-0.7	0.1	1.1
Townsend deprivation index at recruitment	0.4	0.6	1.8	0.8	1.3	-0.5	-0.5	-0.3	0.8
Medication: Ramipril	0.4	0.5	2.0	-0.6	-0.2	-1.4	-0.4	-0.1	-0.7
Illnesses of siblings	0.4	0.5	1.5	0.8	0.6	0.8	0.2	0.0	1.2
Time employed in main current job	0.4	0.5	1.1	-0.1	0.6	-0.7	-0.9	-1.0	0.1
Worrier / anxious feelings	0.4	0.8	3.4	-0.3	-0.6	1.8	0.5	0.7	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.0	-0.1	-0.8	-1.4	-0.3	0.2	-0.3
Lung cancer (father)	0.4	0.4	1.1	1.1	0.1	-0.7	0.8	0.2	0.5
Arm fat-free mass (right)	0.4	1.9	7.9	0.5	0.2	2.8	1.0	1.4	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.0	0.4	-0.2	-1.4	0.5	0.7	-0.1
Emphysema/chronic bronchitis	0.4	0.4	1.2	-0.3	0.4	-0.5	-0.9	-1.1	-0.2
Pulse rate, automated reading	0.4	1.3	5.0	-1.6	-0.5	-0.1	-0.0	-0.1	-2.2
Number of full sisters	0.4	0.5	1.2	1.1	-0.4	-0.0	0.1	0.8	0.9
Overall health rating	0.4	0.9	2.7	-1.2	-0.0	-0.7	-0.3	-0.6	-1.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	0.6	-1.0	-0.4	0.5	1.0	0.5
Medication: Aspirin	0.4	0.6	2.7	-0.3	-0.1	-1.6	-0.3	0.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.7	-0.5	-0.9	0.4	0.5	-1.0
Whole body fat-free mass	0.4	2.3	10.0	0.5	-0.0	3.2	0.9	1.4	0.6
Eye problems/disorders: Cataract	0.4	0.5	1.3	1.1	-0.0	-0.4	0.6	0.5	0.9
Mineral and other dietary supplements	0.4	0.5	1.5	0.1	-0.7	-1.2	0.8	0.3	-0.5
Medication: Aspirin	0.4	0.6	3.0	-0.1	0.1	-1.7	-0.3	0.1	-0.5
Whole body water mass	0.4	2.1	10.1	0.5	0.1	3.2	0.7	1.2	0.7
Number of operations (self-reported)	0.4	0.6	1.3	0.4	0.2	-1.1	1.0	0.9	-0.7
Major Depression (MDD)	0.3	0.3	0.8	-0.1	0.8	0.2	-0.9	-0.3	0.6
Breast Cancer	0.3	0.7	2.1	1.0	1.4	0.8	-0.4	-0.4	0.6
Age at First Birth	0.3	0.5	2.5	0.1	-0.1	1.6	-0.4	0.2	0.4
HDL Cholesterol	0.3	0.4	1.0	1.0	0.7	-0.1	0.0	-0.7	0.8
Blood Eosinophil Count	0.3	2.1	9.8	-0.6	-0.4	3.1	-1.2	-1.0	0.6
Heel T-Score	0.3	2.3	6.6	-1.1	-2.6	1.9	0.6	1.1	-0.8
Smoking Status	0.3	0.6	1.9	0.5	0.6	-0.1	1.4	1.0	-0.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	0.2	0.6	-1.0	0.0	-0.3	-0.6
Taking other prescription medications	0.3	0.5	2.1	0.2	0.1	-1.4	0.7	0.2	-0.5
Allergy	0.3	0.7	1.2	-0.1	0.9	-1.1	-0.9	-0.8	0.7
Falls in the last year	0.3	0.4	0.8	0.9	0.5	0.5	-0.4	0.3	0.8
Arm fat mass (right)	0.3	1.4	7.0	-0.1	-0.7	-2.7	0.0	-0.8	-0.0
Leg fat mass (right)	0.3	1.3	7.3	0.2	-0.7	-2.7	0.1	-0.4	0.2
Arm predicted mass (right)	0.3	1.8	6.6	0.8	0.6	2.6	0.9	1.3	0.6
Alcohol intake frequency.	0.3	0.7	1.8	-0.2	0.5	1.0	-1.1	-1.4	-0.2
Chest pain or discomfort	0.3	0.5	1.2	-0.4	-0.7	0.1	-0.1	0.9	-1.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.8	-0.3	-0.4	0.8	0.7	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	-0.5	0.4	-0.5	0.2	-0.2	-1.1
Arm fat mass (left)	0.3	1.3	6.9	-0.1	-0.8	-2.6	-0.1	-0.7	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.5	0.9	0.1	-0.5	0.0	0.9
Alcohol drinker status: Never	0.3	0.3	1.0	0.2	-0.8	1.0	-0.2	0.2	0.3
Basal metabolic rate	0.3	1.5	6.7	0.4	-0.2	2.6	0.7	1.0	0.6
Arm fat-free mass (left)	0.3	1.6	5.0	0.9	0.2	2.2	1.1	1.5	0.7
Basal cell carcinoma (self-reported)	0.3	0.4	1.4	-0.1	0.6	1.2	-0.5	-0.2	0.4
Alcohol drinker status: Previous	0.3	0.4	0.9	0.9	0.3	0.5	0.4	0.4	0.9
Pack years of smoking	0.3	0.4	0.9	-0.5	-1.0	0.4	-0.3	1.0	-0.4
Leg fat mass (left)	0.3	1.3	6.8	-0.1	-0.7	-2.6	-0.0	-0.5	-0.0
Arm predicted mass (left)	0.3	1.6	5.3	0.8	0.0	2.3	1.0	1.4	0.7
Prostate Cancer	0.2	0.3	0.8	-0.0	0.7	-0.6	0.1	-0.2	-0.9
Mean Putamen Volume	0.2	0.3	0.8	-0.1	0.3	-0.8	-0.9	-0.1	0.1
HbA1C	0.2	0.2	0.3	-0.6	-0.5	-0.5	-0.1	-0.2	-0.5
Sensitivity / hurt feelings	0.2	0.3	1.6	-0.1	-1.3	0.3	-0.0	0.0	0.3
Leg fat-free mass (left)	0.2	1.1	5.1	0.1	-0.6	2.2	0.6	0.8	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.1	0.7	0.1	0.4	-0.1	-0.6
Leg predicted mass (left)	0.2	1.0	4.7	0.1	-0.5	2.2	0.6	0.8	0.5
Trunk fat mass	0.2	0.8	3.1	-0.1	-0.7	-1.8	-0.4	-0.8	0.5
Had other major operations	0.2	0.3	1.1	0.5	0.4	0.1	-0.1	1.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.2	-1.1	-1.1	-0.1	-0.6	-0.7	-0.4
Medication: Simvastatin	0.2	0.3	0.7	0.5	-0.0	-0.3	0.8	0.8	0.2
Hip circumference	0.2	0.8	1.7	1.1	0.6	-1.1	-0.1	-0.3	1.3
Number of full brothers	0.2	0.3	1.2	-0.3	-1.1	0.4	0.5	0.3	-0.3
Heart disease (mother)	0.2	0.3	0.7	-0.5	-0.0	0.4	0.1	0.8	-0.8
Whole body fat mass	0.2	1.0	4.8	0.1	-0.6	-2.2	-0.4	-0.8	0.5
Had major operations	0.2	0.3	0.8	0.0	0.1	-0.7	0.6	0.3	-0.9
Leg fat-free mass (right)	0.2	1.3	6.5	0.1	-0.5	2.5	0.6	0.8	0.5
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.1	0.5	-0.9	0.2	0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	-0.2	-0.7	0.4	0.7	0.5	-0.4
Leg predicted mass (right)	0.2	1.3	6.6	0.0	-0.4	2.6	0.5	0.8	0.4
High cholesterol (Self-reported)	0.2	0.4	1.0	-1.0	0.1	0.5	-0.2	-0.4	-1.0
Medication: Atorvastatin	0.2	0.3	0.7	-0.2	0.6	-0.4	0.6	0.0	-0.9
Cholesterol lowering medication	0.2	0.3	0.7	-0.8	-0.3	-0.5	-0.1	-0.5	-0.9
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	0.2	-0.4	-1.0	0.3	0.8	-0.1
Waist Hip Ratio (WHR)	0.1	0.4	1.9	0.1	1.4	-0.1	-0.3	-0.3	-0.2
Hair Pigment	0.1	3.4	8.1	0.1	-1.0	2.9	1.8	2.8	-0.3
Tanning	0.1	0.6	2.6	0.3	0.0	1.6	0.2	1.0	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.4	0.1	0.5	0.3	0.6	-0.2
Waist circumference	0.1	0.5	2.1	0.3	0.3	-1.5	-0.2	-0.6	0.4
Mouth/teeth dental problems	0.1	0.2	0.3	-0.5	0.4	0.4	-0.3	-0.5	-0.2
Impedance of arm (right)	0.1	0.6	1.4	-1.1	-1.2	0.7	-0.3	-0.1	-0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.2	0.4	0.7	0.5	0.1	0.6
Impedance of arm (left)	0.1	0.3	0.8	-0.8	-0.9	0.6	-0.1	0.1	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	0.2	0.7	-0.4	0.2	0.1	-0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.2	-0.5	-0.2	-0.2	0.3	-0.6
Medication: Gliclazide	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.4	-0.3	-0.1
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.6	0.0	0.4	0.2	0.2	-0.3
Impedance of leg (right)	0.0	0.1	0.2	-0.3	0.1	0.2	-0.5	0.0	-0.2
Impedance of leg (left)	0.0	0.1	0.2	-0.5	0.1	0.2	-0.3	0.1	-0.4
Weight	0.0	0.2	0.4	0.5	-0.3	0.2	0.5	0.5	0.6
Impedance of whole body	0.0	0.1	0.4	-0.6	-0.5	0.4	-0.3	0.1	-0.2

Hub : Genes

PREX1

Models

Trait associations