Best TWAS P=1.91e-13 · Best GWAS P=2.46e-13 conditioned to 0.000455
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MGAT3 | 0.04 | 0.00 | blup | 392 | 0.00 | 1.9e-01 | -6.8 | 6.4 | 1.4e-10 | -0.73 | 0.04 | 0.69 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -6.8 | 7.0 | 2.0e-12 | -0.96 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | MGAT3 | 0.15 | 0.01 | lasso | 4 | 0.00 | 2.3e-01 | -6.5 | 6.4 | 1.1e-10 | -0.87 | 0.03 | 0.64 | FALSE |
| 4 | GTEx | Esophagus Muscularis | MGAT3 | 0.09 | 0.02 | enet | 15 | 0.02 | 1.3e-02 | -6.0 | 7.3 | 2.1e-13 | -0.46 | 0.11 | 0.50 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -7.2 | 7.2 | 6.4e-13 | -0.97 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Nerve Tibial | SYNGR1 | 0.26 | 0.18 | enet | 27 | 0.21 | 3.6e-15 | -6.5 | -6.2 | 4.2e-10 | 0.88 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Nerve Tibial | TAB1 | 0.15 | 0.13 | lasso | 5 | 0.15 | 1.0e-10 | -6.4 | -6.3 | 3.7e-10 | 0.85 | 0.53 | 0.47 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -7.2 | 7.0 | 2.2e-12 | -0.96 | 0.01 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MGAT3 | 0.04 | 0.01 | blup | 48 | 0.04 | 2.3e-05 | -4.6 | 7.4 | 1.9e-13 | -0.62 | 0.25 | 0.45 | TRUE |