[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) : ←

chr22:40,903,421-43,229,137

Best TWAS P=9.24e-12 · Best GWAS P=1.14e-09 conditioned to 0.408

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CHADL	0.08	0.06	lasso	8	0.05	2.8e-07	4.9	-5.2	1.8e-07	-0.14	0.04	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WBP2NL	0.28	0.25	enet	16	0.35	1.3e-43	-5.2	-6.1	1.2e-09	-0.82	0.09	0.91	FALSE
3	GTEx	Adipose Subcutaneous	CYP2D6	0.26	0.10	enet	34	0.20	1.2e-16	4.4	5.5	3.6e-08	0.59	0.45	0.55	FALSE
4	GTEx	Adipose Subcutaneous	NAGA	0.13	0.04	enet	10	0.03	9.0e-04	-5.2	-5.2	1.9e-07	-0.81	0.04	0.94	FALSE
5	GTEx	Adrenal Gland	CYP2D6	0.37	0.14	lasso	12	0.16	2.3e-06	4.4	5.4	5.2e-08	0.61	0.34	0.65	FALSE
6	GTEx	Artery Aorta	CYP2D6	0.24	0.14	lasso	5	0.24	1.6e-13	4.5	5.6	1.8e-08	0.66	0.65	0.34	FALSE
7	GTEx	Artery Aorta	NAGA	0.08	0.07	lasso	3	0.07	1.7e-04	-5.2	-5.3	1.1e-07	-0.89	0.13	0.75	FALSE
8	GTEx	Artery Tibial	CYP2D6	0.29	0.23	lasso	6	0.28	1.5e-22	-5.3	5.9	4.7e-09	0.76	0.18	0.82	FALSE
9	GTEx	Artery Tibial	NAGA	0.07	0.05	lasso	4	0.05	1.6e-04	-5.4	-5.8	5.3e-09	-0.94	0.02	0.98	FALSE
10	GTEx	Brain Caudate basal ganglia	CYP2D6	0.47	0.42	enet	18	0.43	1.1e-13	-5.2	5.8	8.6e-09	0.84	0.18	0.82	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CYP2D6	0.49	0.38	enet	16	0.49	1.6e-14	4.4	5.5	3.2e-08	0.72	0.37	0.63	FALSE
12	GTEx	Brain Cerebellum	SLC25A5P1	0.24	0.11	enet	16	0.14	7.3e-05	4.0	-5.9	4.2e-09	-0.40	0.18	0.50	FALSE
13	GTEx	Brain Cortex	CYP2D6	0.51	0.33	lasso	6	0.47	1.5e-14	4.5	5.5	4.5e-08	0.63	0.86	0.14	FALSE
14	GTEx	Brain Frontal Cortex BA9	CYP2D6	0.51	0.20	lasso	5	0.34	9.0e-10	-5.2	5.8	8.6e-09	0.74	0.31	0.68	FALSE
15	GTEx	Brain Hippocampus	CYP2D6	0.39	0.22	lasso	9	0.32	2.9e-08	-5.2	5.9	4.0e-09	0.78	0.20	0.77	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	CYP2D6	0.44	0.38	enet	17	0.37	6.4e-11	-5.3	5.4	5.3e-08	0.86	0.17	0.83	FALSE
17	GTEx	Brain Putamen basal ganglia	CYP2D6	0.45	0.20	enet	18	0.32	2.9e-08	-5.3	5.2	2.2e-07	0.82	0.20	0.78	FALSE
18	GTEx	Breast Mammary Tissue	CCDC134	0.09	0.02	lasso	4	0.01	6.5e-02	-5.3	-5.3	1.3e-07	-0.42	0.08	0.33	FALSE
19	GTEx	Breast Mammary Tissue	CYP2D6	0.14	0.00	enet	28	0.02	3.4e-02	4.4	6.7	2.2e-11	0.41	0.08	0.44	FALSE
20	GTEx	Breast Mammary Tissue (Male)	CYP2D6	0.34	-0.01	lasso	6	0.00	3.2e-01	-5.3	6.1	9.2e-10	0.81	0.04	0.65	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	CYP2D6	0.25	0.16	lasso	7	0.12	7.7e-05	-5.2	5.3	9.1e-08	0.88	0.15	0.80	FALSE
22	GTEx	Cells Transformed fibroblasts	CCDC134	0.10	0.05	enet	18	0.06	2.5e-05	-5.3	-5.6	2.5e-08	-0.57	0.05	0.94	FALSE
23	GTEx	Cells Transformed fibroblasts	NAGA	0.12	0.15	lasso	7	0.15	1.3e-11	-5.3	-5.8	6.0e-09	-0.87	0.16	0.84	FALSE
24	GTEx	Cells Transformed fibroblasts	RP4-756G23.5	0.07	0.06	enet	8	0.03	2.7e-03	4.9	-5.1	3.0e-07	-0.16	0.05	0.93	FALSE
25	GTEx	Colon Sigmoid	CYP2D6	0.14	0.11	enet	7	0.13	2.9e-05	-5.3	5.3	1.5e-07	0.85	0.05	0.90	FALSE
26	GTEx	Colon Transverse	CYP2D6	0.23	0.21	lasso	5	0.23	4.1e-11	-5.3	5.2	1.6e-07	0.87	0.18	0.82	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	CYP2D6	0.33	0.17	enet	19	0.26	5.7e-10	4.6	5.7	1.5e-08	0.62	0.75	0.24	FALSE
28	GTEx	Esophagus Mucosa	CYP2D6	0.29	0.41	lasso	6	0.38	6.0e-27	-5.2	5.2	2.2e-07	0.89	0.19	0.81	FALSE
29	GTEx	Esophagus Mucosa	L3MBTL2	0.16	0.11	enet	17	0.12	3.4e-08	5.0	-5.5	3.3e-08	-0.11	0.04	0.95	FALSE
30	GTEx	Esophagus Mucosa	SLC25A5P1	0.09	0.10	lasso	6	0.09	1.2e-06	5.3	-5.4	7.7e-08	-0.53	0.13	0.86	FALSE
31	GTEx	Esophagus Muscularis	NAGA	0.07	0.08	lasso	2	0.06	9.4e-05	-5.2	-5.3	1.0e-07	-0.88	0.10	0.80	FALSE
32	GTEx	Heart Atrial Appendage	RP4-756G23.5	0.27	0.06	lasso	6	0.04	7.0e-03	5.6	-5.7	1.5e-08	-0.18	0.01	0.90	TRUE
33	GTEx	Liver	OLA1P1	0.37	0.40	lasso	1	0.35	1.7e-10	-5.2	-5.2	1.7e-07	-0.86	0.15	0.85	FALSE
34	GTEx	Liver	NDUFA6-AS1	0.38	0.25	enet	12	0.28	2.0e-08	-5.2	-5.3	1.1e-07	-0.88	0.14	0.86	FALSE
35	GTEx	Liver	RP1-257I20.14	0.31	0.09	enet	19	0.06	1.1e-02	-5.2	-5.6	1.8e-08	-0.65	0.06	0.70	FALSE
36	GTEx	Lung	CYP2D6	0.28	0.28	lasso	4	0.26	1.3e-19	-5.2	5.6	2.7e-08	0.85	0.18	0.82	FALSE
37	GTEx	Nerve Tibial	CYP2D6	0.32	0.21	lasso	6	0.24	2.8e-17	-5.2	5.7	1.3e-08	0.73	0.19	0.81	FALSE
38	GTEx	Nerve Tibial	NAGA	0.12	0.09	lasso	6	0.08	1.8e-06	-5.4	-5.9	3.8e-09	-0.89	0.04	0.96	FALSE
39	GTEx	Nerve Tibial	SLC25A5P1	0.11	0.08	lasso	5	0.06	2.9e-05	5.3	-5.9	4.0e-09	-0.73	0.06	0.92	FALSE
40	GTEx	Pancreas	CYP2D6	0.48	0.34	lasso	3	0.36	6.5e-16	-5.2	5.2	1.7e-07	0.88	0.18	0.82	FALSE
41	GTEx	Pituitary	CYP2D6	0.42	0.42	lasso	6	0.39	1.0e-10	-5.2	5.5	4.6e-08	0.88	0.17	0.82	FALSE
42	GTEx	Pituitary	L3MBTL2	0.19	0.15	enet	17	0.19	1.6e-05	4.6	-5.4	5.6e-08	-0.14	0.08	0.80	FALSE
43	GTEx	Pituitary	OLA1P1	0.31	0.10	enet	9	0.08	5.0e-03	-5.3	-5.2	2.0e-07	-0.76	0.10	0.59	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CYP2D6	0.27	0.31	lasso	3	0.31	2.7e-17	-5.3	5.3	1.2e-07	0.88	0.17	0.83	FALSE
45	GTEx	Skin Sun Exposed Lower leg	CCDC134	0.12	0.04	lasso	5	0.04	3.8e-04	4.4	-5.2	2.2e-07	-0.39	0.29	0.29	FALSE
46	GTEx	Stomach	CYP2D6	0.38	0.25	lasso	6	0.27	3.1e-13	-5.3	5.7	1.1e-08	0.81	0.18	0.82	FALSE
47	GTEx	Testis	SREBF2	0.25	0.03	lasso	12	0.04	4.6e-03	-5.2	-5.7	1.5e-08	-0.77	0.12	0.82	FALSE
48	GTEx	Thyroid	CCDC134	0.14	0.11	enet	9	0.11	1.8e-08	-5.3	-5.2	2.3e-07	-0.51	0.14	0.86	FALSE
49	GTEx	Thyroid	SLC25A5P1	0.11	0.08	enet	13	0.07	3.2e-06	5.3	-6.0	2.2e-09	-0.60	0.12	0.87	FALSE
50	GTEx	Uterus	NAGA	0.19	0.07	enet	8	0.06	2.6e-02	4.6	-5.3	1.0e-07	-0.75	0.05	0.37	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	NAGA	0.08	0.10	lasso	4	0.09	7.3e-12	-5.4	-5.3	1.1e-07	-0.91	0.11	0.89	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CYP2D6	0.14	0.15	enet	2	0.15	1.1e-12	-5.3	5.6	1.7e-08	0.86	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYP2D6	0.12	0.12	enet	2	0.13	8.8e-25	-5.3	5.7	1.1e-08	0.85	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	TNFRSF13C	0.02	0.00	blup	42	0.01	2.5e-03	5.0	-6.4	1.1e-10	-0.43	0.01	0.16	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CYP2D6	0.14	0.09	enet	2	0.14	1.3e-07	-5.3	5.8	6.1e-09	0.76	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC134	0.13	0.07	blup	45	0.10	2.7e-06	-5.3	-5.7	1.1e-08	-0.40	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	CYP2D6	0.12	0.11	enet	2	0.13	7.7e-08	-5.3	5.8	5.9e-09	0.79	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Esophageal Carcinoma	CYP2D6	0.14	0.11	lasso	1	0.11	1.9e-04	-5.3	5.3	1.2e-07	0.89	0.00	0.87	FALSE
59	The Cancer Genome Atlas	Glioblastoma Multiforme	CYP2D6	0.28	0.26	lasso	2	0.25	4.5e-08	-5.3	5.5	3.5e-08	0.88	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CYP2D6	0.21	0.20	lasso	1	0.20	2.2e-22	-5.3	5.3	1.2e-07	0.89	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP2D6	0.14	0.15	enet	2	0.17	1.4e-18	-5.3	5.8	7.1e-09	0.82	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCDC134	0.08	0.04	enet	7	0.06	2.3e-04	-5.3	-6.7	2.0e-11	-0.35	0.01	0.68	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CYP2D6	0.15	0.07	blup	2	0.15	4.0e-09	-5.3	5.8	8.4e-09	0.71	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NAGA	0.08	0.07	enet	5	0.07	1.1e-04	-5.4	-5.4	8.3e-08	-0.92	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WBP2NL	0.13	0.07	lasso	4	0.03	5.2e-03	5.3	-5.3	1.2e-07	-0.53	0.07	0.86	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP2D6	0.19	0.17	enet	2	0.26	3.6e-29	4.5	5.7	9.6e-09	0.70	0.01	0.98	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM109B	0.04	0.03	lasso	3	0.03	8.7e-05	-5.2	-5.2	1.8e-07	-0.92	0.00	0.98	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP2NL	0.08	0.05	lasso	4	0.08	1.5e-09	-5.2	-6.0	2.0e-09	-0.86	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	CYP2D6	0.12	0.13	enet	2	0.15	7.4e-17	-5.3	5.8	6.0e-09	0.80	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	WBP2NL	0.05	0.04	blup	142	0.04	1.2e-05	-5.3	-6.7	2.0e-11	-0.85	0.02	0.96	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCDC134	0.04	0.03	enet	6	0.04	4.7e-05	5.3	-5.3	1.1e-07	-0.51	0.00	0.99	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CYP2D6	0.20	0.23	enet	2	0.25	3.4e-28	-5.3	5.8	6.6e-09	0.81	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CYP2D6	0.11	0.10	enet	2	0.11	1.1e-07	4.5	5.4	5.6e-08	0.58	0.03	0.92	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CYP2D6	0.19	0.13	enet	2	0.14	1.6e-06	-5.3	5.8	6.8e-09	0.82	0.00	0.99	FALSE
75	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CYP2D6	0.23	0.18	enet	2	0.18	1.3e-07	-5.3	5.6	2.1e-08	0.87	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC134	0.06	0.04	blup	45	0.06	5.1e-07	-5.3	-5.8	6.6e-09	-0.45	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYP2D6	0.22	0.24	enet	2	0.25	2.8e-26	-5.3	5.7	1.1e-08	0.85	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	WBP2NL	0.04	0.03	lasso	8	0.03	5.6e-04	-5.4	-5.7	1.1e-08	-0.89	0.02	0.96	FALSE
79	The Cancer Genome Atlas	Rectum Adenocarcinoma	CYP2D6	0.22	0.21	lasso	2	0.18	4.1e-05	-5.3	5.6	2.0e-08	0.87	0.00	0.94	FALSE
80	The Cancer Genome Atlas	Soft Tissue Sarcoma	CYP2D6	0.11	0.09	blup	2	0.10	1.4e-06	-5.3	5.8	6.3e-09	0.81	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CYP2D6	0.11	0.00	blup	2	0.00	2.7e-01	4.5	5.7	1.3e-08	0.67	0.00	0.19	FALSE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	CYP2D6	0.12	0.10	blup	2	0.10	6.5e-08	-5.3	5.8	6.6e-09	0.81	0.00	1.00	FALSE
83	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CYP2D6	0.42	0.31	lasso	1	0.31	9.7e-12	-5.3	5.3	1.2e-07	0.89	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	CYP2D6	0.35	0.31	lasso	1	0.31	7.8e-31	-5.3	5.3	1.2e-07	0.89	0.00	1.00	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	NAGA	0.10	0.14	lasso	4	0.14	6.1e-14	-5.3	-5.3	1.4e-07	-0.89	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	WBP2NL	0.08	0.01	enet	11	0.03	3.0e-04	5.3	-6.8	9.2e-12	-0.66	0.07	0.84	TRUE
87	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CYP2D6	0.19	0.06	blup	2	0.10	9.6e-04	-5.3	5.8	6.5e-09	0.75	0.00	0.77	FALSE