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chr11:46,543,524-48,559,571

Best TWAS P=1.32e-09 · Best GWAS P=2.61e-08 conditioned to 0.984

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-5.4	-5.4	5.3e-08	0.93	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-5.4	5.5	3.6e-08	-0.93	0.02	0.98	FALSE
3	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	-5.4	5.4	5.4e-08	-0.88	0.02	0.96	FALSE
4	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	3.9	-5.7	1.2e-08	0.60	0.12	0.46	FALSE
5	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-5.3	-5.4	5.3e-08	0.95	0.02	0.94	FALSE
6	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	3.7	-5.4	8.2e-08	0.78	0.04	0.65	FALSE
7	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	-5.5	5.6	1.8e-08	-0.85	0.01	0.99	FALSE
8	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-5.4	5.6	2.3e-08	-0.95	0.03	0.91	FALSE
9	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	-5.4	5.4	5.4e-08	-0.88	0.02	0.98	FALSE
10	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-5.4	5.2	1.6e-07	-0.92	0.04	0.96	FALSE
11	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	-5.4	5.4	5.4e-08	-0.88	0.02	0.93	FALSE
12	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-5.4	5.2	1.8e-07	-0.83	0.03	0.95	FALSE
13	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-4.9	5.4	6.4e-08	-0.96	0.02	0.98	FALSE
14	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-5.5	-6.1	1.3e-09	0.92	0.01	0.98	TRUE
15	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-5.4	5.6	2.4e-08	-0.93	0.02	0.98	FALSE
16	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	-5.4	5.8	7.1e-09	-0.91	0.02	0.98	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-5.4	5.2	1.6e-07	-0.82	0.02	0.98	FALSE
18	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-5.4	5.5	4.9e-08	-0.98	0.02	0.97	FALSE
19	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-5.5	5.6	2.1e-08	-1.00	0.01	0.99	FALSE
20	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	-4.0	-5.4	6.7e-08	0.85	0.05	0.95	FALSE
21	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	4.6	-5.1	2.6e-07	0.41	0.38	0.19	FALSE
22	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-5.5	5.5	2.9e-08	-0.99	0.01	0.99	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-5.5	-5.6	2.0e-08	0.99	0.01	0.99	FALSE
24	YFS	Blood	DDB2	0.02	0.00	bslmm	306	0.01	1.9e-04	3.9	-5.2	2.1e-07	0.17	0.24	0.06	FALSE
25	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	-5.3	-5.5	3.7e-08	0.79	0.03	0.96	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-5.6	5.7	1.4e-08	-0.99	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACP2	0.02	0.01	blup	44	0.02	2.7e-04	3.9	-6.0	1.7e-09	0.46	0.00	0.19	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	3.8	5.4	7.1e-08	-0.65	0.03	0.56	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	-5.5	-5.2	2.3e-07	0.82	0.01	0.70	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	-5.4	5.4	5.4e-08	-0.88	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	2.7	-5.2	2.5e-07	0.85	0.00	0.50	FALSE
32	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-5.4	5.4	5.7e-08	-0.93	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-5.5	5.6	2.7e-08	-1.00	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-5.4	-5.4	6.2e-08	0.88	0.01	0.96	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-5.5	5.7	1.4e-08	-0.98	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-5.6	5.6	2.7e-08	-0.99	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACP2	0.09	0.04	enet	12	0.06	5.0e-07	3.7	-5.2	2.0e-07	0.53	0.02	0.54	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	-4.9	-5.2	1.8e-07	0.61	0.01	0.89	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-5.5	-5.6	2.8e-08	1.00	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-5.5	5.6	2.8e-08	-1.00	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	-4.9	-5.5	3.8e-08	0.88	0.01	0.98	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-5.4	5.6	2.2e-08	-0.92	0.00	0.96	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	MYBPC3	0.04	0.02	enet	10	0.04	2.9e-05	-4.9	5.7	1.5e-08	-0.72	0.01	0.96	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-5.5	-5.3	1.2e-07	0.92	0.01	0.91	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	-4.9	-5.2	1.7e-07	0.84	0.01	0.62	FALSE
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-5.6	5.7	1.3e-08	-0.99	0.00	0.93	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	-5.4	5.7	1.5e-08	-0.81	0.00	0.87	FALSE