Best TWAS P=8.09e-10 · Best GWAS P=5.28e-07 conditioned to 0.906
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ORMDL3 | 0.09 | 0.08 | enet | 10 | 0.06 | 4.2e-08 | -4.8 | -5.5 | 3.0e-08 | 0.90 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Brain Cerebellum | GSDMB | 0.24 | 0.09 | lasso | 2 | 0.08 | 2.1e-03 | 4.5 | -5.5 | 2.9e-08 | 0.43 | 0.03 | 0.82 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | ORMDL3 | 0.24 | 0.09 | enet | 21 | 0.07 | 7.8e-06 | -4.8 | -5.7 | 1.1e-08 | 0.80 | 0.07 | 0.92 | FALSE |
| 4 | GTEx | Lung | ORMDL3 | 0.16 | 0.13 | enet | 15 | 0.14 | 1.6e-10 | -4.4 | -5.6 | 2.5e-08 | 0.91 | 0.05 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GSDMB | 0.06 | 0.05 | enet | 7 | 0.05 | 2.2e-06 | -4.9 | -5.1 | 3.0e-07 | 0.96 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IKZF3 | 0.03 | 0.01 | blup | 43 | 0.02 | 1.3e-02 | -4.4 | 6.1 | 8.1e-10 | -0.83 | 0.02 | 0.48 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf37 | 0.03 | 0.01 | blup | 19 | 0.01 | 4.5e-02 | 4.8 | -5.3 | 1.4e-07 | 0.49 | 0.00 | 0.46 | FALSE |