TWAS hub - C17orf37

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Papillary Cell Carcinoma	0.287	0.1230	9.8e-05	0.015	0.074	0.058	NA	0.032	0.04300	0.00005	0.00032	NA	0.0060
2	TCGA	Brain Lower Grade Glioma	0.039	0.0254	4.2e-03	0.008	0.008	0.010	NA	0.008	0.04000	0.03900	0.02300	NA	0.0370
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.085	0.0500	6.4e-04	0.033	0.046	0.052	NA	0.037	0.00260	0.00042	0.00019	NA	0.0015
4	TCGA	Soft Tissue Sarcoma	0.124	0.0550	2.1e-04	0.051	0.019	0.045	NA	0.034	0.00054	0.02500	0.00110	NA	0.0043
5	TCGA	Thyroid Carcinoma	0.032	0.0220	9.5e-03	0.008	0.008	0.002	NA	0.008	0.04900	0.04500	0.20000	NA	0.0470

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Eosinophil Count	14.8	114.2	144.0	11.0	10.3	11.0	12.0	8.9
Blood White Count	12.6	93.0	292.4	5.3	-17.1	-10.4	-5.3	3.0
Lupus	11.2	17.0	27.7	-4.0	-2.7	-3.6	-4.6	-5.3
Respiratory disease	10.5	23.4	54.2	4.1	-7.4	-3.7	-0.4	5.7
Asthma (self-reported)	9.8	19.6	47.1	3.6	-6.9	-3.4	-0.5	5.1
Asthma	9.5	18.7	43.3	3.6	-6.6	-3.2	-0.3	5.1
Irritable Bowel Disease (IBD)	8.7	20.6	60.7	0.2	7.8	5.3	3.6	-1.1
High cholesterol (Self-reported)	8.2	14.5	18.7	3.3	3.9	4.0	4.3	3.4
Ulcerative Colitis (UC)	7.2	13.5	39.5	0.1	6.3	4.1	3.3	0.0
Loud music exposure frequency	6.9	7.5	11.5	2.9	2.6	3.4	2.8	1.8
Hayfever/allergic rhinitis (self-reported)	6.4	8.5	17.4	3.7	0.2	2.1	2.6	4.2
Allergy	6.0	13.9	36.2	-4.7	2.6	-0.2	-2.2	-6.0
Mouth/teeth dental problems: Mouth ulcers	5.9	9.3	20.8	1.9	4.6	3.8	2.8	0.6
Hypothyroidism (self reported)	5.6	12.8	22.6	4.8	2.5	3.7	3.9	2.6
Neck or shoulder pain in last month	5.6	8.0	12.2	3.5	2.7	2.7	2.8	2.2
Primary Biliary Cirrhosis	5.1	7.2	15.8	-4.0	1.2	-1.0	-1.6	-3.9
Hayfever, allergic rhinitis or eczema	5.1	11.1	24.9	4.5	-0.2	1.8	2.8	5.0
Crohns Disease (2017)	5.0	11.1	32.5	-0.2	5.7	3.9	2.1	-1.8
Medication: Cholesterol lowering	4.8	7.4	11.1	2.4	2.8	2.9	3.3	2.1
Allergy or Eczema	4.6	12.1	25.2	5.0	-0.2	1.9	2.9	4.8
Shortness of breath walking on level ground	4.4	5.2	9.4	3.1	1.0	1.9	2.3	2.5
Ever depressed for a whole week	4.2	5.2	9.7	2.6	1.3	1.8	2.2	3.1
Heart attack	4.1	5.2	8.1	2.1	1.6	2.1	2.6	2.8
Wheeze or whistling in the chest in last year	4.1	7.3	17.8	4.2	-1.4	0.5	1.8	3.6
HDL Cholesterol	3.8	6.3	18.8	-2.9	1.5	0.7	-1.1	-4.3
Ulcerative Colitis	3.8	5.4	15.5	-1.5	3.9	2.3	1.5	-1.4
Hypothyroidism/myxoedema (self-reported)	3.8	7.4	10.5	3.2	1.8	3.2	3.0	2.1
Medication: Levothyroxine sodium	3.6	6.2	9.1	3.0	1.7	2.8	2.7	1.9
Myopia	3.6	5.2	15.0	1.9	0.1	1.5	2.2	3.9
Heart attack/myocardial infarction (self-reported)	3.6	4.6	7.3	2.0	1.4	2.0	2.4	2.7
Fed-up feelings	3.5	6.3	9.5	3.1	2.2	2.5	2.9	1.6
Medication: Ventolin 100micrograms inhaler	3.5	4.5	9.8	1.5	-3.0	-1.1	-0.1	3.1
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	5.2	-1.5	-2.2	-2.3	-1.8	-1.5
Knee pain experienced in last month	3.3	5.1	7.6	2.2	2.7	2.8	2.2	0.9
Miserableness	3.2	5.5	14.1	3.8	0.6	2.1	2.3	1.9
Pain experienced in last month	3.2	5.4	7.3	-2.6	-2.7	-2.6	-2.2	-0.8
Medication for cholesterol, blood pressure or diabetes	3.1	5.2	6.8	-2.1	-2.2	-2.4	-2.6	-1.9
Alzheimer’s Disease (in father)	3.0	3.3	5.6	2.4	1.1	1.8	1.9	1.6
Crohns Disease (2012)	3.0	4.8	13.3	-1.8	3.6	2.3	1.2	-1.0
Number of self-reported non-cancer illnesses	3.0	5.2	10.8	3.3	-0.0	1.3	1.9	3.1
Illnesses of mother	2.9	3.5	5.9	-2.4	-1.5	-1.6	-2.4	-1.1
Ever had bowel cancer screening	2.9	3.4	5.3	1.9	2.3	1.7	2.1	-0.5
Mother’s age at death	2.8	3.5	7.9	-1.4	-1.1	-1.6	-1.9	-2.8
Lung cancer (father)	2.7	3.2	4.3	-1.3	-1.9	-2.1	-2.0	-1.5
Heart disease (mother)	2.7	3.3	5.0	2.2	0.5	1.3	2.2	2.2
Leg pain on walking	2.7	3.4	4.2	2.0	1.5	1.7	2.1	1.9
Depressed Affect (Nagel 2018)	2.6	5.4	10.4	3.2	0.0	2.5	2.6	1.8
Medication: Ibuprofen	2.6	3.1	4.5	-0.7	-2.1	-1.9	-1.7	-2.1
Medication: Atenolol	2.5	3.1	3.7	1.8	1.6	1.7	1.9	1.8
Pulse wave Arterial Stiffness index	2.5	2.9	4.8	1.4	1.5	1.5	1.9	2.2
Pulse wave peak to peak time	2.5	2.9	4.4	-1.4	-1.5	-1.5	-1.9	-2.1
Angina	2.4	3.2	5.5	0.7	1.9	1.7	2.3	1.8
Noisy workplace	2.4	3.0	3.8	1.3	1.7	1.7	2.0	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	4.5	2.1	1.9	2.1	1.8	0.5
Cardiovascular Disease	2.2	7.3	10.1	2.1	3.2	3.2	2.7	2.2
Overall health rating	2.2	4.7	8.2	2.9	1.8	2.2	2.2	1.5
Illness, injury, bereavement, stress in last 2 years	2.2	2.6	4.0	-1.5	-1.7	-2.0	-1.6	-1.2
Mood swings	2.2	4.0	7.0	2.2	1.6	2.6	1.9	1.3
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	3.7	1.6	1.2	1.4	1.8	1.9
Angina (self-reported)	2.1	2.8	4.8	0.7	1.9	1.6	2.2	1.7
Medication: Allopurinol	2.1	2.8	4.5	-1.4	-0.9	-2.1	-1.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	15.7	-2.0	-0.1	0.0	-1.6	-4.0
Wears glasses or contact lenses	2.1	2.5	5.1	1.1	2.3	1.9	1.0	-1.2
Medication: Ramipril	2.0	2.6	4.9	0.6	1.7	1.6	1.4	2.2
Rheumatoid Arthritis	1.9	2.6	5.4	-0.2	2.3	1.4	0.3	-2.3
Number of incorrect matches in round	1.9	3.2	6.0	-1.5	-2.5	-2.1	-1.5	1.0
Worry too long after embarrassment	1.9	3.1	5.2	-0.8	-1.8	-1.6	-2.3	-2.0
Chest pain or discomfort	1.9	2.7	9.8	3.1	-0.8	0.0	1.1	1.4
Average weekly beer plus cider intake	1.9	2.7	4.0	1.1	2.0	2.0	1.9	0.9
Breast Cancer	1.8	4.4	6.8	-2.6	-2.3	-1.9	-2.5	-0.5
Blood Red Count	1.8	17.4	59.0	0.2	3.1	1.8	3.9	7.7
Frequency of depressed mood in last 2 weeks	1.8	2.5	4.7	2.2	1.0	1.6	1.6	1.4
Health satisfaction	1.8	2.3	5.0	2.2	0.9	1.5	1.5	1.1
Taking other prescription medications	1.7	2.7	5.9	2.4	-1.3	0.3	1.0	2.2
Average weekly red wine intake	1.7	2.5	7.4	-1.8	0.5	-0.6	-1.1	-2.7
Eye problems/disorders: Cataract	1.7	2.0	3.1	1.4	1.6	1.1	1.8	1.0
Supplements: Calcium	1.7	1.9	3.4	-0.5	-1.3	-1.3	-1.8	-1.5
Heart disease (siblings)	1.7	2.1	4.0	1.4	1.4	1.1	1.3	2.0
Age at First Birth	1.6	2.4	3.3	-1.8	-1.4	-1.1	-1.6	-1.7
Pain all over the body in last month	1.6	1.8	2.6	1.4	0.8	1.0	1.6	1.6
Alzheimer’s Disease (including proxy)	1.5	2.2	2.6	1.6	1.6	1.6	1.6	0.9
Hearing difficulty/problems with background noise	1.5	2.4	4.0	-1.5	-0.7	-1.4	-1.8	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.3	2.5	1.1	1.3	1.7	0.1
Emphysema/chronic bronchitis	1.5	1.6	4.4	-0.4	-2.1	-1.4	-1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	4.5	2.1	1.1	1.4	2.1	1.9
Guilty feelings	1.5	2.2	3.9	-0.6	-1.9	-1.5	-2.0	-0.9
Medication: Paracetamol	1.5	2.3	5.2	-0.5	-1.1	-1.4	-1.6	-2.3
Schizophrenia vs Biploar Disorder	1.4	1.8	3.5	-1.9	-0.2	-1.2	-1.2	-1.7
Schizophrenia (2014)	1.4	3.1	4.8	-1.8	-2.1	-2.2	-1.7	0.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.2	1.2	1.4	1.5	1.3	-0.5
Hip circumference	1.4	6.1	12.2	1.2	3.5	2.8	2.2	1.9
Hair/balding pattern: Pattern 4	1.3	3.1	6.1	1.6	1.2	1.4	1.9	2.5
Medication: Seretide 50 evohaler	1.3	1.5	4.3	2.1	-0.9	0.2	0.6	1.3
Ovarian Cancer	1.2	1.6	2.3	-1.5	-1.5	-1.4	-1.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.1	-0.1	-1.8	-1.1	-1.1	-1.4
Gout (self-reported)	1.2	1.7	3.7	-1.6	0.5	-0.9	-1.2	-1.9
Supplements: Vitamin C	1.2	1.4	3.3	1.2	-1.8	-0.5	-0.1	1.4
Back pain experienced in last month	1.2	1.7	4.7	2.2	1.1	1.0	1.3	0.2
Ever smoked	1.2	2.2	4.7	2.2	0.1	-0.0	1.4	2.1
Body Mass Index (BMI) (2010)	1.1	1.5	3.2	-0.2	1.8	1.5	1.0	0.9
Hearing difficulty/problems: Yes	1.1	1.6	2.6	-0.9	-0.9	-1.5	-1.2	-1.6
Medication: Co-codamol	1.1	1.3	3.1	0.3	1.8	1.6	0.9	0.0
Medication: Lansoprazole	1.1	1.2	2.2	-0.6	-1.1	-1.0	-1.1	-1.5
Qualifications: College or University degree	1.1	3.4	9.1	-1.7	-0.3	-1.2	-1.8	-3.0
Hypertension (Self-reported)	1.1	2.9	3.5	1.8	1.6	1.9	1.6	1.7
Vascular/heart problems diagnosed by doctor	1.1	2.9	3.5	-1.5	-1.7	-1.9	-1.9	-1.6
Smoking Status	1.0	2.4	5.7	1.7	0.8	0.2	1.5	2.4
Medication for hormone replacement therapy	1.0	1.2	2.0	-0.5	-1.4	-1.3	-1.2	-0.6
Financial difficulties in last 2 years	1.0	1.3	2.4	1.6	0.8	1.1	0.8	1.3
Father’s age at death	1.0	1.3	6.0	-0.2	0.5	-0.2	-0.5	-2.5
Medication: Blood pressure	1.0	1.8	2.4	1.2	1.3	1.6	1.5	1.2
Medication: Aspirin	1.0	1.3	3.4	1.8	0.6	1.1	1.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.2	1.8	1.1	0.8	1.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.5	1.6	-0.2	0.4	1.2	1.3
Lung FVC	0.9	4.3	16.4	-1.4	-0.6	0.1	-1.7	-4.0
Ever had hysterectomy (womb removed)	0.9	1.0	3.2	1.8	0.5	0.4	1.1	-0.0
Current tobacco smoking	0.9	1.4	4.2	1.2	0.6	0.3	1.0	2.0
Maternal smoking around birth	0.9	1.3	3.9	-2.0	-0.9	-1.2	-0.5	-0.4
High blood pressure (mother)	0.9	1.3	2.0	1.4	1.2	1.1	1.3	0.4
Worrier / anxious feelings	0.9	1.7	6.7	2.6	-0.0	1.0	0.7	0.5
Mouth/teeth dental problems: Dentures	0.9	1.6	4.7	0.0	-1.5	-1.0	0.0	2.2
Prospective memory result	0.9	1.1	2.0	1.2	0.5	1.0	1.0	1.4
High blood pressure (siblings)	0.9	1.3	2.1	-0.8	-1.0	-1.1	-1.4	-1.3
Leg fat percentage (right)	0.9	3.3	5.9	0.4	2.4	2.1	1.7	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.9	-1.3	-0.5	-0.6	-1.0	-1.4
Illnesses of siblings: Diabetes	0.9	1.1	2.2	0.2	1.1	0.9	1.5	1.1
Long-standing illness, disability or infirmity	0.9	1.4	4.5	2.1	-0.2	0.2	0.9	1.2
Risk taking	0.9	1.3	1.9	1.1	1.4	1.3	1.1	-0.8
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.4	0.9	0.8	1.1	1.2	1.1
Basal cell carcinoma (self-reported)	0.9	1.0	2.1	1.4	-1.2	-0.5	0.3	1.1
Bipolar Disorder (2018)	0.8	1.3	3.8	1.4	-0.9	-0.2	0.2	1.9
Schizophrenia (2018)	0.8	1.7	3.2	-1.1	-1.8	-1.6	-1.0	0.5
Qualifications: CSEs or equivalent	0.8	1.0	1.4	0.6	1.2	1.1	0.9	1.1
Past tobacco smoking	0.8	1.4	2.9	-1.7	-0.0	0.3	-1.2	-1.6
Alcohol usually taken with meals	0.8	1.3	3.8	-1.2	-0.0	-0.6	-1.1	-1.9
Qualifications: None of the above	0.8	1.7	5.7	1.1	-0.7	0.3	1.1	2.4
Arm fat percentage (right)	0.8	3.0	5.2	0.5	1.9	2.0	1.6	2.3
Headache pain in last month	0.8	1.5	3.1	1.8	0.9	1.3	1.2	0.4
Medication: Gliclazide	0.8	0.9	1.7	-1.3	-0.9	-1.1	-0.7	-0.2
Alcohol drinker status: Never	0.8	0.9	2.0	0.9	0.6	0.8	0.9	1.4
Leg fat percentage (left)	0.8	3.0	6.2	-0.0	2.5	2.0	1.5	1.5
Number of operations (self-reported)	0.8	1.1	4.2	2.0	-0.2	-0.2	1.2	-0.0
Alcohol drinker status: Previous	0.8	0.9	1.8	-0.9	-1.1	-1.4	-0.9	0.4
Bipolar Disorder or Schizophrenia	0.7	1.8	3.8	0.0	-2.0	-1.4	-0.7	1.6
Waist Hip Ratio (WHR)	0.7	3.3	5.9	-1.8	-1.6	-1.4	-1.7	-2.4
Trunk fat percentage	0.7	3.0	4.2	0.4	1.9	2.0	1.6	2.1
Townsend deprivation index at recruitment	0.7	1.1	3.1	1.0	0.4	0.5	0.8	1.8
High blood pressure	0.7	2.0	2.6	1.3	1.6	1.6	1.4	1.2
Neuroticism score	0.7	1.5	4.6	2.2	0.8	1.3	0.5	0.3
Impedance of arm (right)	0.7	3.1	6.7	2.2	-0.5	0.9	1.7	2.6
Impedance of arm (left)	0.7	3.0	5.9	2.3	-0.5	0.9	1.7	2.4
Birth weight of first child	0.7	1.2	3.3	-0.5	-1.8	-1.4	-0.7	0.2
Peak expiratory flow (PEF)	0.7	1.6	2.8	0.0	-1.4	-1.0	-1.4	-1.7
Pulse rate, automated reading	0.7	2.3	4.6	-1.1	-2.1	-2.1	-0.7	0.9
Had major operations	0.7	0.8	2.2	-0.1	-1.5	-1.1	-0.8	-0.5
Arm fat percentage (left)	0.7	2.9	4.7	0.7	1.8	1.9	1.6	2.2
Loneliness, isolation	0.7	1.0	2.1	0.8	1.0	1.4	0.8	0.7
Mineral and other dietary supplements	0.7	0.9	2.0	-1.4	-0.8	-1.1	-0.8	-0.2
Breast cancer (self-reported)	0.7	0.8	1.7	0.2	0.9	0.7	1.1	1.3
Medication: Aspirin	0.7	0.9	1.9	1.4	0.4	0.9	1.1	0.7
Arm fat mass (left)	0.7	2.8	4.9	0.5	2.2	2.1	1.4	1.6
Commuting to job workplace: Public transport	0.7	0.8	3.6	0.3	0.2	0.4	-0.2	-1.9
Medication: Lisinopril	0.7	1.0	2.9	-0.9	-0.1	-0.5	-0.9	-1.7
Fractured/broken bones in last 5 years	0.7	0.9	1.6	-0.1	-1.0	-1.0	-0.9	-1.3
Depression (Nagel 2018)	0.6	0.9	1.7	1.3	0.0	1.3	1.1	0.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	0.3	1.3	0.8	0.9	0.5
Mean Putamen Volume	0.6	0.7	1.5	-0.4	-1.2	-0.8	-0.9	0.4
Neuroticism	0.6	1.5	4.0	2.0	0.7	1.4	1.0	0.4
Number of treatments/medications taken	0.6	1.1	3.0	1.7	-0.8	0.3	0.8	1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.8	1.7	0.4	0.8	0.7	-0.2
Trunk fat mass	0.6	2.6	4.2	0.3	2.0	2.1	1.3	1.6
Nervous feelings	0.6	1.2	2.5	-0.3	-0.8	-0.4	-1.6	-1.6
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	-0.6	-0.9	-1.2	-1.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.9	-2.2	0.1	-1.0	-0.7	-0.2
Mouth/teeth dental problems	0.6	1.0	1.6	0.2	-1.3	-1.0	-1.1	-1.0
Diabetes (self-reported)	0.6	0.9	1.6	-0.5	-1.2	-1.3	-1.0	0.0
Medication: Simvastatin	0.6	0.9	2.1	1.4	0.5	0.7	1.0	0.7
Alcohol intake versus 10 years previously	0.6	1.0	1.9	-1.4	-0.2	-0.3	-1.4	-0.9
Arm fat mass (right)	0.6	2.4	4.3	0.3	2.1	1.9	1.3	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.4	1.0	1.0	1.6	0.4	0.6
Body fat percentage	0.6	2.3	3.3	0.2	1.8	1.8	1.3	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.6	-0.8	-0.9	-0.2	1.3
Alcohol intake frequency.	0.6	1.5	6.2	0.7	-0.7	-0.2	0.4	2.5
Medication: Atorvastatin	0.6	0.8	1.5	0.1	1.2	1.2	0.9	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	1.3	0.7	0.4	1.1	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.2	1.5	-0.1	-0.4	0.6	0.4
Supplements: Zinc	0.5	0.5	2.2	1.5	-0.5	-0.2	0.3	-0.3
Severe depression (siblings)	0.5	0.5	1.3	0.9	0.4	0.3	0.7	1.1
Waist circumference	0.5	1.9	5.0	0.1	2.2	1.7	1.1	0.7
Fluid intelligence score	0.5	1.1	2.5	-0.9	-0.1	-0.9	-1.1	-1.6
Number of live births	0.5	0.7	1.1	0.9	-0.6	-0.2	1.0	1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	7.7	-0.2	-0.0	0.2	-1.2	-2.8
Pulse rate	0.5	0.9	2.7	-0.5	-1.0	-1.6	-0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.6	-0.4	-0.4	-0.2	-0.5	-1.6
Blood clot in the leg (DVT)	0.5	0.6	1.0	1.0	0.2	0.6	1.0	1.0
Glaucoma (self-reported)	0.5	0.5	1.1	1.0	0.2	0.4	0.8	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	1.4	0.0	0.8	0.6	0.8
Eye problems/disorders: None of the above	0.5	0.6	1.4	-0.7	-0.7	-0.7	-0.4	1.2
Medication for pain relief, constipation, heartburn	0.5	0.8	3.3	-1.8	0.1	-0.4	-0.4	0.7
Whole body fat mass	0.5	1.9	3.7	-0.0	1.9	1.8	1.1	1.3
Leg fat mass (right)	0.5	1.9	4.2	-0.1	2.1	1.8	1.0	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	0.6	0.5	0.6	0.3	1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	-1.2	-0.7	-0.5	-0.6	0.5
Smoking status: Current	0.5	0.8	2.6	1.1	0.2	-0.1	0.6	1.6
Leg fat mass (left)	0.5	2.0	4.6	-0.3	2.1	1.8	1.0	1.0
HbA1C	0.4	0.4	1.2	-1.1	0.6	-0.2	0.3	-0.7
Blood Platelet Count	0.4	4.4	15.2	-2.4	0.7	-0.1	-0.6	-3.9
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	0.4	-1.2	-1.2	-0.1	0.6
Lung FEV1/FVC ratio	0.4	1.9	5.7	-1.4	2.4	0.6	0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-0.1	-0.6	-1.1	-0.5	-0.7
Body mass index (BMI)	0.4	1.7	4.0	-0.1	2.0	1.6	0.9	1.0
Had other major operations	0.4	0.5	0.8	0.8	-0.9	-0.9	-0.2	-0.5
Forced vital capacity (FVC)	0.4	1.6	6.5	0.4	-0.6	0.2	-1.1	-2.5
Weight	0.4	1.8	3.9	0.3	2.0	1.9	0.9	0.7
Happiness	0.4	0.5	1.3	0.4	0.5	0.3	0.7	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	5.1	0.4	0.6	0.8	-0.3	-2.2
Tense / ‘highly strung’	0.4	0.7	1.0	0.9	1.0	1.0	0.4	-0.6
Medication: Paracetamol	0.4	0.7	1.4	0.3	-0.8	-0.6	-0.9	-1.2
Number of full brothers	0.4	0.5	1.9	-0.7	-0.0	-0.2	-0.0	1.4
Migraine (self-reported)	0.4	0.5	0.8	0.8	0.9	0.8	0.6	0.3
Medication: Omeprazole	0.4	0.5	1.5	1.2	0.6	0.2	0.8	-0.2
Number of full sisters	0.4	0.5	1.4	1.0	-0.1	0.3	0.1	1.2
Suffer from ‘nerves’	0.4	0.7	2.5	0.6	0.2	0.6	-0.2	-1.6
Smoking status: Previous	0.4	0.5	1.0	1.0	0.3	-0.0	0.9	0.9
Friendships satisfaction	0.4	0.5	2.5	0.3	-0.2	0.1	0.2	1.6
Osteoporosis (self-reported)	0.4	0.4	1.3	-0.1	-0.3	-0.1	-0.9	-1.1
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.4	-0.6	-0.8	-0.9	-0.6
Hearing aid user	0.4	0.5	1.4	-0.3	-0.1	-0.8	-0.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.9	1.0	0.2	0.7	0.9	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	0.9	-0.1	0.4	0.8	0.8
Impedance of whole body	0.4	2.1	4.0	1.9	-0.2	0.7	1.6	2.0
Neuroticism (Nagel 2018)	0.3	0.8	2.9	1.7	0.0	0.7	0.6	-0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	0.7	-0.3	-0.3	-0.2	1.0
Hair Pigment	0.3	7.9	12.2	-1.3	-3.0	-2.8	-3.0	-3.5
Average weekly spirits intake	0.3	0.4	0.7	0.8	0.3	0.7	0.7	-0.5
Vitamin and mineral supplements	0.3	0.4	1.2	-0.4	1.1	0.5	0.5	-0.4
Impedance of leg (right)	0.3	1.5	2.6	1.6	0.1	0.7	1.5	1.5
Stomach or abdominal pain in last month	0.3	0.4	1.5	1.2	-0.3	-0.2	-0.2	-0.5
Supplements: Glucosamine	0.3	0.4	0.9	1.0	0.6	0.8	0.2	0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.8	-0.1	-0.4	0.0	0.0	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.5	0.8	0.7	-0.1	-0.8
Had menopause	0.3	0.4	0.8	0.8	-0.9	-0.6	-0.0	0.1
Time employed in main current job	0.3	0.3	0.8	-0.4	-0.7	-0.3	-0.2	-0.9
Falls in the last year	0.3	0.4	1.6	-0.3	0.3	-0.3	-0.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.5	0.7	0.5	0.9	0.2
Depression (self-reported)	0.3	0.3	0.8	0.9	0.3	0.8	0.2	0.3
Breastfed as a baby	0.3	0.4	0.8	0.6	0.2	0.4	0.6	0.9
Medication: Amlodipine	0.3	0.4	1.6	1.3	0.3	0.4	0.5	-0.2
Birth weight	0.3	0.7	2.3	-1.1	0.2	0.1	0.0	1.5
Forced vital capacity (FVC), Best measure	0.3	1.0	3.7	0.9	-0.3	0.5	-0.4	-1.9
Exposure to tobacco smoke outside home	0.3	0.4	1.0	1.0	-0.6	0.8	-0.1	0.1
Comparative body size at age 10	0.3	0.8	2.5	-1.6	0.5	-0.8	-0.6	-0.4
Number of children fathered	0.3	0.3	0.4	0.6	0.3	0.4	0.7	0.6
Family relationship satisfaction	0.3	0.4	0.9	0.7	-0.6	-0.3	0.2	1.0
Diabetes diagnosed by doctor	0.3	0.5	1.2	-0.1	-1.1	-1.0	-0.6	-0.0
Medication for cholesterol	0.3	0.4	1.0	0.1	0.7	1.0	0.8	0.2
Financial situation satisfaction	0.3	0.4	1.6	1.3	-0.5	0.3	0.2	-0.1
Irritability	0.3	0.5	0.9	0.7	0.8	0.6	-0.1	-0.9
Commuting to job workplace: Cycle	0.3	0.4	1.0	0.4	0.7	0.3	-0.4	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	-0.6	0.0	-0.9	-0.8	-0.7
Worry (Nagel 2018)	0.2	0.5	1.7	0.6	0.0	0.6	-0.2	-1.3
Major Depression (MDD)	0.2	0.3	0.7	0.8	-0.3	0.3	0.1	0.8
Reaction Time	0.2	0.3	0.6	0.7	-0.8	-0.2	-0.6	0.1
Prostate Cancer	0.2	0.3	1.4	-0.2	-0.2	0.2	-0.1	1.2
Fasting Glucose	0.2	0.3	0.7	-0.1	-0.4	-0.5	0.3	0.8
Triglycerides	0.2	0.3	0.5	0.7	-0.6	-0.6	-0.1	0.4
BMI	0.2	1.0	3.0	-0.9	1.7	1.0	0.3	0.3
Systolic Blood Pressure	0.2	1.0	1.4	0.8	0.8	1.1	1.2	1.1
Chronotype (morning person)	0.2	0.6	1.4	-1.1	0.1	0.5	-0.2	-1.2
Medication: Metformin	0.2	0.3	0.7	0.3	-0.8	-0.8	-0.3	-0.1
Diabetes (father)	0.2	0.3	0.7	0.8	-0.7	-0.2	0.4	0.3
Diabetes (mother)	0.2	0.3	0.8	-0.3	0.4	-0.0	-0.9	-0.7
Average weekly fortified wine intake	0.2	0.3	0.8	0.3	0.9	0.7	0.1	-0.2
Age when periods started (menarche)	0.2	0.4	0.6	-0.7	-0.8	-0.1	-0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.9	-1.4	0.2	-0.5	-0.1	0.2
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.7	-0.7	0.1	0.3	0.6
Multivitamins +/- minerals	0.2	0.2	0.5	-0.2	-0.7	-0.5	-0.6	0.4
Impedance of leg (left)	0.2	0.8	1.5	0.9	0.2	0.5	1.2	1.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.6	0.1	0.3	0.5	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	0.5	-0.7	-0.6	-0.9	-0.9
Length of working week for main job	0.2	0.2	0.4	0.6	-0.5	-0.5	-0.1	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.3	0.1	0.6	0.1	-0.8
Pulse wave reflection index	0.2	0.2	0.4	-0.2	0.5	0.6	0.4	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.8	-0.4	-0.6	-0.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.9	0.5	0.4	0.4	0.4
Arm fat-free mass (right)	0.2	0.8	1.5	-0.7	1.2	0.7	-0.5	-1.2
Arm predicted mass (right)	0.2	1.0	1.9	-0.8	1.2	0.6	-0.6	-1.4
Comparative height size at age 10	0.2	0.9	1.8	1.0	0.9	1.3	1.0	0.4
Illnesses of father: Heart disease	0.2	0.3	0.4	0.3	-0.6	-0.5	0.6	0.7
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.6	0.9	0.2	-0.4	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.7	0.3	0.8	0.6	0.0	-0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.8	0.2	0.5	-0.6	-0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.8	0.3	0.1	-0.1	-0.7
Medication: Bendroflumethiazide	0.2	0.2	0.4	-0.2	0.6	0.3	0.6	0.6
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.6	0.1	0.0	-0.5	-0.9
Age started oral contraceptive pill	0.2	0.2	0.4	0.3	0.6	0.4	0.2	-0.7
Cholesterol lowering medication	0.2	0.3	0.7	-0.0	-0.8	-0.8	-0.5	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.2	0.5	-0.4	-0.5	-0.7
LDL Cholesterol	0.1	0.1	0.3	0.1	0.3	0.6	0.4	-0.2
Neuroticism (2016)	0.1	0.2	0.7	0.9	-0.0	0.5	-0.1	0.0
Heel T-Score	0.1	0.7	1.8	-1.2	1.3	0.4	0.1	0.2
Height	0.1	1.3	2.7	-0.1	-1.6	0.1	-1.3	-1.5
Hand grip strength (left)	0.1	0.3	0.7	0.7	-0.1	0.6	0.1	0.9
Sensitivity / hurt feelings	0.1	0.1	0.4	0.5	0.1	0.0	0.0	0.6
Systolic blood pressure, automated reading	0.1	0.4	0.6	-0.1	0.7	0.8	0.8	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.5	0.1	0.1	-0.2	-0.7
Pack years adult smoking proportion	0.1	0.2	0.5	-0.3	-0.3	-0.0	0.3	0.7
Leg fat-free mass (left)	0.1	0.4	1.1	-0.1	0.9	1.0	-0.1	-0.2
Hand grip strength (right)	0.1	0.3	1.0	0.4	-1.0	-0.4	-0.5	0.4
Relative age voice broke	0.1	0.2	0.8	0.9	-0.4	0.0	0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.3	-0.2	-0.7	0.3	-0.1
Leg predicted mass (left)	0.1	0.4	1.0	-0.2	1.0	1.0	-0.1	-0.2
Trunk fat-free mass	0.1	0.4	0.7	-0.4	0.8	0.6	-0.4	-0.8
Trunk predicted mass	0.1	0.4	0.7	-0.4	0.8	0.6	-0.4	-0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.0	-0.5	-0.2	0.1	-0.4
Age at first live birth	0.1	0.2	0.4	-0.6	-0.3	-0.1	-0.4	-0.6
Mean time to correctly identify matches	0.1	0.2	0.7	0.9	-0.4	-0.2	-0.0	0.4
Age at last live birth	0.1	0.1	0.2	0.0	-0.4	0.2	0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	-0.1	0.1	0.2	0.3	0.7
Whole body fat-free mass	0.1	0.5	0.9	-0.5	0.9	0.8	-0.4	-0.6
Leg fat-free mass (right)	0.1	0.5	0.7	-0.7	0.9	0.8	-0.4	-0.5
Whole body water mass	0.1	0.5	0.7	-0.6	0.9	0.7	-0.5	-0.8
Leg predicted mass (right)	0.1	0.5	0.8	-0.7	0.9	0.8	-0.4	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.4	-0.2	-0.1	-0.4	0.1
Medication: Blood pressure	0.1	0.2	0.6	0.3	0.3	0.1	0.3	0.7
Basal metabolic rate	0.1	0.6	1.6	-0.3	1.2	1.1	0.0	-0.2
Arm fat-free mass (left)	0.1	0.7	2.0	-0.4	1.4	1.0	-0.1	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.6	-0.6	0.8	0.2	0.5	0.1
Unable to work because of sickness or disability	0.1	0.2	0.4	0.6	0.4	0.4	0.3	0.0
Pack years of smoking	0.1	0.2	0.5	-0.7	-0.3	-0.1	0.2	0.6
Arm predicted mass (left)	0.1	0.5	1.2	-0.5	1.1	0.7	-0.3	-0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.1	0.1	-0.2	0.1	-0.2
Tanning	0.0	0.1	0.2	-0.0	-0.4	0.0	0.2	0.3
Relative age of first facial hair	0.0	0.0	0.1	0.3	-0.1	0.2	0.2	-0.1
Sitting height	0.0	0.2	0.4	-0.6	0.2	-0.0	-0.6	-0.3
Illnesses of siblings	0.0	0.0	0.2	0.0	0.1	0.1	0.0	-0.4
Standing height	0.0	0.3	0.6	0.7	0.1	0.7	0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.1	0.1	-0.2	0.2	0.4
Commuting to job workplace: Walk	0.0	0.1	0.2	0.3	0.1	-0.1	-0.4	-0.0
Ever taken oral contraceptive pill	0.0	0.1	0.1	0.1	0.3	0.2	0.1	0.4
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2	0.1

Hub : Genes

C17orf37

Models

Trait associations