Best TWAS P=1.45e-32 · Best GWAS P=1.84e-46 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Heart Atrial Appendage | MIR4519 | 0.13 | 0.05 | lasso | 5 | 0.04 | 5.6e-03 | -7.17 | -11.9 | 1.4e-32 | -0.61 | 0.03 | 0.64 | TRUE |
| 4 | GTEx | Whole Blood | ITGAM | 0.07 | 0.03 | lasso | 4 | 0.02 | 3.3e-03 | -8.39 | 8.6 | 7.7e-18 | 0.41 | 0.37 | 0.11 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ITGAM | 0.04 | 0.01 | blup | 54 | 0.02 | 6.1e-03 | -1.26 | 7.9 | 2.3e-15 | 0.57 | 0.03 | 0.12 | TRUE |
| 5 | METSIM | Adipose | HSD3B7 | 0.05 | 0.02 | bslmm | 230 | 0.02 | 2.1e-04 | -1.22 | 6.9 | 5.2e-12 | 0.26 | 0.12 | 0.05 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | BCL7C | 0.11 | 0.01 | lasso | 3 | 0.00 | 2.1e-01 | -7.17 | -6.9 | 6.9e-12 | -0.29 | 0.07 | 0.14 | TRUE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ITGAD | 0.21 | 0.11 | blup | 38 | 0.11 | 7.1e-10 | 0.79 | 5.5 | 4.0e-08 | 0.23 | 1.00 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ITGAD | 0.12 | 0.06 | enet | 15 | 0.05 | 1.8e-06 | 0.79 | 5.5 | 5.0e-08 | 0.21 | 0.90 | 0.01 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | SETD1A | 0.04 | 0.03 | bslmm | 243 | 0.02 | 3.9e-03 | 1.80 | 6.6 | 4.6e-11 | 0.19 | 0.22 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ITGAX | 0.03 | 0.02 | lasso | 3 | 0.01 | 5.3e-04 | -2.71 | -6.3 | 3.3e-10 | -0.50 | 0.25 | 0.06 | FALSE |