[Hub]/) : Traits : Primary Biliary Cirrhosis : ← →

chr17:37,101,380-39,048,774

Best TWAS P=3.17e-11 · Best GWAS P=2.58e-11 conditioned to 0.101

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	6.0	5.8	8.8e-09	-0.82	0.04	0.72	FALSE
2	GTEx	Cells Transformed fibroblasts	GSDMB	0.11	0.02	enet	18	0.06	4.9e-05	-6.5	-5.3	9.0e-08	0.75	0.01	0.99	FALSE
3	GTEx	Cells Transformed fibroblasts	STARD3	0.08	0.01	enet	18	0.01	3.3e-02	-5.2	-5.7	1.2e-08	0.45	0.18	0.47	FALSE
4	GTEx	Cells Transformed fibroblasts	ORMDL3	0.24	0.09	enet	21	0.07	7.8e-06	-5.7	-6.4	1.9e-10	0.83	0.01	0.99	FALSE
5	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	6.0	-5.6	2.6e-08	0.89	0.04	0.96	FALSE
6	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	6.0	-6.2	4.5e-10	0.85	0.12	0.42	FALSE
7	GTEx	Lung	GSDMB	0.07	0.07	lasso	4	0.05	1.5e-04	-5.7	-6.3	2.8e-10	0.92	0.01	0.98	FALSE
8	GTEx	Lung	ORMDL3	0.16	0.13	enet	15	0.14	1.6e-10	-6.5	-6.0	2.2e-09	0.92	0.02	0.98	FALSE
9	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	-4.3	-6.0	2.1e-09	0.80	0.18	0.55	FALSE
10	GTEx	Skin Sun Exposed Lower leg	ORMDL3	0.04	0.02	lasso	5	0.01	1.1e-01	-5.2	-5.7	1.2e-08	0.51	0.02	0.85	FALSE
11	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	-5.7	-5.7	9.6e-09	0.91	0.06	0.94	FALSE
12	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	-5.7	-5.9	2.7e-09	0.94	0.05	0.95	FALSE
13	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	-6.5	-6.5	9.3e-11	0.97	0.01	0.99	FALSE
14	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	-5.7	-5.8	5.1e-09	0.90	0.17	0.83	FALSE
15	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	-6.2	-6.2	6.8e-10	0.93	0.01	0.99	FALSE
16	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	5.9	5.3	1.2e-07	-0.86	0.04	0.96	FALSE
17	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	6.1	-6.3	3.7e-10	0.88	0.02	0.98	FALSE
18	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	-6.6	-6.2	5.1e-10	0.90	0.01	0.99	FALSE
19	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	-6.6	-6.0	2.4e-09	0.87	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	6.3	-5.5	3.6e-08	0.91	0.03	0.97	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	6.3	-5.7	1.2e-08	0.89	0.02	0.62	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMB	0.06	0.05	enet	7	0.05	2.2e-06	-6.2	-6.4	2.0e-10	0.96	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	-6.3	-6.2	5.7e-10	0.94	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	-6.3	-6.2	4.3e-10	0.93	0.02	0.81	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	5.9	-6.2	4.6e-10	0.94	0.03	0.96	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	6.0	-5.7	9.5e-09	0.88	0.04	0.95	FALSE
27	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	5.3	-5.8	5.5e-09	0.90	0.02	0.89	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	-5.8	-5.9	3.2e-09	0.92	0.04	0.96	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	IKZF3	0.03	0.01	blup	43	0.02	1.3e-02	-6.7	6.0	1.6e-09	-0.84	0.01	0.74	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZPBP2	0.08	0.09	enet	5	0.10	6.1e-08	-6.3	6.1	9.3e-10	-0.94	0.03	0.97	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	-6.2	-6.6	3.2e-11	0.89	0.01	0.99	TRUE
32	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	-5.7	-6.3	3.0e-10	0.93	0.03	0.97	FALSE