Hub : Genes

PNMT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0270	0.02500	-0.002	-0.002	-0.002	0.004	-0.002	6.7e-01	0.87000	0.69000	0.082	7.4e-01
2	GTEx	Heart Atrial Appendage	0.1360	0.0630	0.00073	-0.006	NA	-0.006	NA	-0.004	7.9e-01	NA	0.82000	NA	5.3e-01
3	GTEx	Heart Left Ventricle	0.0614	0.0332	0.00420	0.031	NA	0.021	NA	0.027	8.7e-03	NA	0.02800	NA	1.3e-02
4	TCGA	Lung Adenocarcinoma	0.0334	0.0189	0.00250	0.006	0.013	0.004	NA	0.008	6.1e-02	0.00930	0.09800	NA	3.3e-02
5	TCGA	Testicular Germ Cell Tumors	0.0670	0.0420	0.00270	0.136	0.051	0.087	NA	0.105	1.6e-05	0.00680	0.00054	NA	1.6e-04
6	TCGA	Thyroid Carcinoma	0.0340	0.0210	0.00034	0.053	0.034	0.031	NA	0.042	6.9e-06	0.00027	0.00045	NA	6.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.3	3.7	7.6	-2.2	2.8	0.9	-1.8	0.0	2.4
Bipolar Disorder or Schizophrenia	2.9	7.1	14.7	-2.4	3.8	2.8	-1.6	0.0	3.4
Depressed Affect (Nagel 2018)	0.5	1.1	4.2	-0.7	-0.8	-2.0	-0.4	0.0	-1.0
Depression (Nagel 2018)	0.8	1.3	3.9	-1.3	-0.6	-2.0	0.4	0.0	-1.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.2	-0.5	0.1	-0.2	0.0	0.4
Neuroticism (Nagel 2018)	0.6	1.4	3.4	0.2	-1.4	-1.8	0.6	0.0	-1.6
Schizophrenia (2018)	1.9	4.0	8.2	-1.3	2.7	2.9	-0.7	0.0	2.5
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.8	-1.0	0.4	-0.6	0.0	-0.6
Worry (Nagel 2018)	2.9	6.0	12.3	1.9	-2.8	-3.5	1.0	0.0	-3.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	0.3	-0.9	-0.2	0.9	-0.5	-0.5
Alzheimer’s Disease (in father)	0.6	0.7	2.8	1.7	-0.4	1.0	0.3	0.1	-0.0
Alzheimer’s Disease (including proxy)	0.6	0.9	1.7	1.2	-1.3	-0.5	1.0	-0.7	-0.7
Crohns Disease (2017)	11.5	25.1	80.0	5.8	-8.9	-2.8	0.4	0.0	-5.4
Irritable Bowel Disease (IBD)	14.9	35.5	116.6	6.9	-10.8	-3.0	0.1	0.0	-6.3
Ulcerative Colitis (UC)	8.8	16.5	57.6	4.8	-7.6	-1.5	-0.4	0.0	-4.0
Major Depression (MDD)	1.0	1.2	2.0	-1.2	1.4	-0.1	0.2	1.4	1.4
Reaction Time	0.9	1.7	3.5	-0.1	1.1	1.5	0.1	1.9	1.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.4	-0.2	0.8	0.3	0.6	0.7
Breast Cancer	0.8	2.0	4.6	-1.3	2.1	0.4	-1.2	1.5	1.4
Ovarian Cancer	1.9	2.5	8.2	1.3	1.1	2.9	0.9	1.2	1.2
Prostate Cancer	1.4	2.0	4.6	2.1	1.3	2.1	0.3	0.0	0.9
Age at First Birth	1.1	1.7	2.8	1.0	-0.4	-1.6	1.1	-1.5	-1.7
Bipolar Disorder (2011)	2.9	2.8	10.4	0.0	0.0	0.0	-2.5	0.0	3.2
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	1.5	-1.5	0.2	-0.4	0.0	-0.4
Coronary Artery Disease (CAD)	0.3	0.3	0.9	1.0	-0.1	0.7	0.3	0.0	0.5
Crohns Disease (2012)	6.6	10.6	33.4	3.4	-5.8	-2.5	0.1	0.0	-3.5
Mean Putamen Volume	3.0	3.4	5.5	-1.6	2.4	1.5	-1.3	2.0	2.1
Fasting Glucose	2.3	2.7	5.2	-1.2	1.1	1.3	-1.2	2.3	2.3
HbA1C	1.0	1.1	2.8	0.2	-1.5	0.7	-1.7	-0.7	-0.7
HDL Cholesterol	20.6	34.4	57.9	5.8	-7.1	-7.0	3.9	0.0	-7.6
LDL Cholesterol	0.4	0.7	2.4	0.0	-0.7	-0.8	0.8	0.0	-1.6
Lupus	6.4	9.6	15.2	2.4	-2.9	-2.9	2.4	-3.8	-3.9
Neuroticism (2016)	0.1	0.2	0.3	0.0	-0.3	-0.4	0.5	-0.5	-0.5
Primary Biliary Cirrhosis	13.0	18.6	38.9	2.2	-6.2	-4.6	-1.6	-4.6	-4.7
Rheumatoid Arthritis	7.6	10.4	20.6	2.0	-4.5	-3.1	0.8	-3.6	-3.8
Schizophrenia (2014)	1.8	3.9	6.6	-1.3	2.5	2.6	-1.6	0.0	2.6
Triglycerides	1.3	2.1	5.3	-2.3	1.5	0.6	-1.2	0.0	1.8
Type 2 Diabetes (T2D) (2012)	1.9	2.2	4.8	-0.7	2.0	2.2	1.2	0.0	1.5
Ulcerative Colitis	9.1	13.1	36.4	3.9	-6.0	-2.7	1.3	0.0	-4.3
Blood Eosinophil Count	1.2	9.3	37.6	-6.1	-1.1	-0.2	-3.2	1.8	1.9
Blood Platelet Count	1.7	19.7	53.0	2.0	-5.5	-7.3	1.6	-3.5	-4.0
Blood Red Count	7.8	75.8	182.2	-4.2	5.9	13.5	-5.4	9.7	9.9
Blood White Count	41.5	307.5	630.0	-25.1	25.0	4.5	-5.9	15.9	16.8
Heel T-Score	0.4	3.5	11.4	1.6	-1.2	3.4	-0.9	1.7	1.4
BMI	0.4	2.0	4.5	2.1	-1.4	2.1	0.0	1.0	0.8
Height	0.4	7.5	18.8	1.2	-0.7	-4.3	-1.4	-3.2	-3.5
Waist Hip Ratio (WHR)	0.4	1.6	4.5	-2.1	-0.5	-1.9	0.1	-0.7	-0.9
Systolic Blood Pressure	0.1	0.5	1.4	-0.2	0.6	0.5	-0.1	-1.2	-1.1
Smoking Status	5.5	13.1	15.9	-3.8	2.6	3.7	-3.6	3.8	4.0
Allergy or Eczema	8.8	23.1	39.3	-5.2	6.3	1.8	0.3	5.8	6.0
Cardiovascular Disease	0.3	1.0	1.7	0.5	-1.2	1.3	-1.0	-0.8	-0.8
Hypothyroidism (self reported)	0.4	0.9	3.5	-0.3	0.3	-1.0	1.9	0.5	0.5
Respiratory disease	49.3	109.8	219.0	-10.9	14.8	6.0	-3.6	11.4	11.9
Type 2 Diabetes (T2D) (2018)	4.9	9.1	15.3	-1.9	3.2	3.9	-2.0	3.2	3.4
Lung FEV1/FVC ratio	1.1	5.5	17.6	3.2	-4.2	0.5	1.9	-0.5	-0.7
Lung FVC	6.2	31.7	69.2	4.7	-4.9	-8.3	4.4	-5.0	-5.4
Neuroticism	0.7	1.7	4.4	0.1	-1.4	-2.1	0.2	-1.3	-1.4
Chronotype (morning person)	0.9	2.0	4.8	1.1	-1.1	-0.2	2.2	-1.5	-1.6
Hair Pigment	0.1	3.0	7.2	0.8	-0.7	-2.7	-0.8	-2.1	-2.1
Tanning	0.0	0.5	1.0	-0.8	0.0	-0.2	-0.7	1.0	0.8
Hand grip strength (left)	0.3	0.9	2.5	-0.4	1.6	-0.3	0.4	1.1	1.1
Number of treatments/medications taken	0.8	1.5	2.9	-1.7	1.7	0.1	-0.6	1.1	1.2
Average weekly spirits intake	0.5	0.7	2.0	-0.7	-0.9	-1.4	-0.6	-0.3	-0.4
Sensitivity / hurt feelings	0.6	1.0	4.1	-0.2	0.4	2.0	-0.6	0.7	0.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.7	-1.9	0.3	-1.4	-0.5	-0.2	-0.2
Hearing difficulty/problems: Yes	0.4	0.7	2.5	0.8	-0.0	1.6	0.5	-0.6	-0.5
Relative age of first facial hair	0.4	0.9	4.0	0.5	-0.6	-2.0	0.4	0.6	0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	0.6	-0.8	-0.9	0.3	-1.0	-1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.7	6.0	-1.7	0.7	0.5	-2.4	0.5	0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.4	-0.8	0.8	-0.7	0.5	0.4
Systolic blood pressure, automated reading	0.2	0.5	1.2	0.5	-0.7	-1.1	0.7	-0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	0.1	-0.9	-0.8	-0.5	-1.6	-1.5
Angina	0.3	0.3	0.8	-0.7	-0.6	-0.1	-0.1	-0.9	-0.6
Medication for hormone replacement therapy	1.4	1.6	4.3	-2.1	1.0	-0.6	-1.8	0.4	0.5
Vitamin and mineral supplements	1.3	1.8	3.7	1.7	-1.4	1.9	1.4	-0.2	-0.3
Supplements: Zinc	0.5	0.6	2.0	0.4	-0.1	-1.4	0.4	-0.9	-0.7
Medication: Co-codamol	3.5	4.1	6.1	1.6	-2.2	-1.8	1.3	-2.5	-2.4
Medication: Metformin	3.2	4.5	6.7	-1.6	1.6	1.7	-2.6	2.5	2.5
Diabetes (father)	0.7	0.9	2.1	-0.2	0.9	-0.6	-0.5	1.4	1.4
Diabetes (mother)	0.7	0.9	2.4	1.5	-1.0	0.3	1.2	-0.4	-0.5
Severe depression (siblings)	2.1	2.3	3.2	-1.7	1.1	0.8	-1.8	1.7	1.8
Pack years adult smoking proportion	2.3	3.6	12.5	-1.5	1.0	1.5	-3.5	1.4	1.2
Impedance of leg (right)	0.5	2.3	4.6	-2.2	1.7	1.5	-1.9	0.5	0.5
Leg fat-free mass (left)	0.3	1.5	5.2	2.3	-1.5	-0.9	0.4	-0.5	-0.6
Trunk fat percentage	0.2	0.6	2.9	0.4	-0.1	1.7	-0.1	0.6	0.5
Hand grip strength (right)	0.7	1.9	5.7	-0.9	2.4	0.1	-0.3	1.5	1.6
Townsend deprivation index at recruitment	4.3	6.1	12.0	-3.5	1.6	2.1	-2.4	2.4	2.4
Current tobacco smoking	2.9	4.7	8.0	-1.8	1.6	2.6	-2.8	1.9	2.0
Average weekly fortified wine intake	0.4	0.4	1.0	0.1	-0.5	0.2	1.0	-0.8	-0.8
Maternal smoking around birth	3.3	4.7	9.2	-1.7	0.9	3.0	-2.9	2.0	1.8
Fed-up feelings	0.5	0.9	2.3	-0.1	-1.5	-0.8	-1.4	-0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	-1.0	-1.0	-1.1	0.3	-1.0	-1.0
Relative age voice broke	0.3	0.4	0.8	-0.9	0.3	-0.9	-0.9	-0.1	-0.0
Taking other prescription medications	4.1	6.3	14.4	-2.9	3.8	1.0	-0.6	2.6	2.7
Age when periods started (menarche)	0.8	1.9	4.5	1.0	-0.5	-2.1	-0.0	-1.6	-1.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.3	-0.0	-0.2	1.3	-1.8	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.5	1.1	-0.4	2.1	-1.1	1.2	1.0
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.7	1.4	-2.4	-1.8	1.1	-0.7	-1.0
Qualifications: CSEs or equivalent	0.2	0.2	0.8	0.7	-0.3	0.9	-0.0	-0.2	-0.1
Serious illness, injury or assault to yourself	0.3	0.3	0.7	-0.6	0.8	-0.3	0.0	0.6	0.6
High blood pressure	0.2	0.6	2.3	-0.7	-0.6	0.1	-1.5	0.5	0.5
Hayfever, allergic rhinitis or eczema	10.6	23.0	37.7	-5.0	6.1	1.9	-0.3	5.9	6.0
Multivitamins +/- minerals	0.4	0.5	1.7	-0.7	1.0	-1.3	-0.0	-0.1	0.1
Stomach or abdominal pain in last month	0.4	0.4	1.1	-1.0	0.5	1.1	-0.4	0.2	0.3
Supplements: Glucosamine	0.4	0.6	2.1	0.5	-0.1	-1.0	1.5	-0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	7.4	-0.8	0.2	0.9	-2.7	1.0	1.0
Medication: Atenolol	0.5	0.6	1.1	-0.6	0.1	1.0	-0.7	0.9	0.9
Medication: Levothyroxine sodium	0.3	0.5	1.2	-0.6	0.2	-0.3	1.1	0.8	0.7
Sitting height	0.1	0.7	1.5	1.1	-1.1	-0.2	-1.2	-0.5	-0.5
Chronic bronchitis/emphysema (father)	1.9	2.2	3.5	-1.7	1.9	0.7	-0.3	1.8	1.8
High blood pressure (mother)	0.6	0.8	2.6	0.9	-1.6	-0.2	-0.5	-0.6	-0.7
Body mass index (BMI)	0.3	1.1	2.5	1.6	-1.0	1.4	0.6	0.7	0.6
Impedance of leg (left)	0.3	1.3	2.6	-1.3	1.1	1.6	-1.5	0.0	0.0
Leg predicted mass (left)	0.3	1.5	5.1	2.3	-1.5	-0.9	0.4	-0.5	-0.6
Trunk fat mass	0.1	0.5	1.5	1.0	-0.7	1.2	0.0	0.3	0.3
Waist circumference	0.2	0.6	2.8	0.6	-1.7	0.4	0.1	0.3	0.1
Number of incorrect matches in round	3.0	5.0	8.3	-1.3	2.9	2.6	-2.3	2.0	2.0
Past tobacco smoking	4.7	8.7	11.6	2.8	-2.2	-3.2	2.6	-3.2	-3.4
Alcohol usually taken with meals	1.3	2.1	4.5	1.1	-1.5	-0.3	0.6	-2.1	-2.0
Nervous feelings	3.4	6.3	10.3	1.9	-1.8	-3.2	1.9	-2.9	-2.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.5	-1.0	-1.3	-1.6	-1.1	-1.2	-1.2
Hearing difficulty/problems with background noise	0.5	0.8	1.4	0.6	-1.2	0.6	-0.4	-1.1	-1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-1.1	0.3	0.8	-0.9	0.1	0.2
Had menopause	1.4	1.7	2.6	-1.6	1.4	-0.2	-1.1	1.4	1.5
Had other major operations	0.3	0.3	0.7	-0.8	0.6	-0.1	-0.8	0.4	0.5
Forced vital capacity (FVC)	2.7	10.5	23.9	3.2	-2.8	-4.9	1.8	-2.8	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.5	1.4	-0.6	2.3	-1.0	0.9	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	-0.6	0.8	1.3	-0.3	0.3	0.5
Qualifications: None of the above	1.8	3.9	5.4	-2.2	2.3	1.3	-1.9	2.0	2.0
Financial difficulties in last 2 years	1.0	1.4	3.2	-0.0	0.4	0.8	-1.0	1.8	1.7
Mouth/teeth dental problems	0.2	0.3	0.9	-0.2	0.4	-1.0	0.4	0.7	0.5
Heart attack	0.4	0.6	1.1	-0.7	0.9	1.0	-0.2	0.6	0.7
Allergy	22.5	51.7	92.4	7.7	-9.6	-3.3	2.1	-8.3	-8.6
Pain all over the body in last month	0.2	0.2	0.8	-0.1	-0.1	0.9	-0.6	0.0	0.0
Diabetes (self-reported)	3.3	5.0	6.3	-2.5	2.3	2.5	-2.0	2.0	2.1
Hayfever/allergic rhinitis (self-reported)	5.2	6.8	17.7	-1.7	4.2	1.5	0.2	3.0	3.1
Medication: Ramipril	1.1	1.4	2.4	-0.6	0.5	1.6	-0.9	1.5	1.5
Medication: Simvastatin	0.6	0.8	2.9	-1.0	0.7	0.5	1.7	0.4	0.5
Fluid intelligence score	0.3	0.6	1.1	0.7	-0.5	1.1	0.0	0.9	0.8
Illnesses of siblings	1.4	2.0	3.3	1.5	-0.9	-1.6	0.4	-1.8	-1.8
Neuroticism score	0.9	1.9	5.1	-0.1	-1.6	-2.3	-0.7	-1.3	-1.3
Weight	0.3	1.2	4.5	2.1	-1.6	0.4	0.1	-0.2	-0.3
Impedance of arm (right)	0.9	4.3	14.5	-3.8	2.6	-0.2	-2.0	0.3	0.5
Arm fat percentage (right)	0.2	0.7	1.9	-0.2	0.2	1.4	0.2	1.0	1.0
Trunk fat-free mass	0.3	2.0	6.8	2.6	-1.8	-0.9	-0.0	-0.6	-0.8
Hip circumference	0.4	1.8	4.3	2.1	-1.9	1.5	-0.3	0.4	0.4
Time employed in main current job	1.6	1.8	4.1	0.4	-0.6	-2.0	0.9	-1.6	-1.6
Alcohol intake versus 10 years previously	0.7	1.1	2.8	1.2	-0.8	1.7	0.4	-0.7	-0.8
Father’s age at death	4.3	5.7	7.6	1.7	-2.7	-2.8	1.9	-2.5	-2.5
Worrier / anxious feelings	0.9	1.6	8.6	-0.5	-0.5	-2.9	0.1	-0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.5	-1.2	-1.0	-0.8	-0.9	0.1	0.0
Falls in the last year	2.3	3.1	9.1	-1.3	-2.3	-3.0	-0.5	-1.0	-1.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.5	0.7	0.2	-0.2	0.6	0.6
Number of live births	3.1	4.4	9.0	-0.1	1.8	3.0	-0.6	2.7	2.6
Forced expiratory volume in 1-second (FEV1)	3.4	11.4	17.1	4.0	-3.6	-4.1	2.7	-2.6	-2.9
Pulse rate	3.6	6.1	9.6	-3.1	1.8	1.7	-2.4	2.7	2.9
Happiness	1.5	1.8	3.5	-1.7	0.5	1.0	-1.9	1.3	1.3
Noisy workplace	0.6	0.8	2.8	-1.7	-0.3	-0.8	-0.5	0.7	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.7	0.2	0.2	-0.9	1.3	-0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.2	-0.9	-0.9	-0.0	0.4	0.2
Mouth/teeth dental problems: Dentures	6.7	11.4	17.9	-2.7	4.2	4.1	-3.0	2.8	3.0
Asthma	41.1	81.1	171.6	-9.2	13.1	5.1	-2.6	9.7	10.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	0.7	-0.4	-1.5	0.2	-0.9	-1.0
Medication: Cholesterol lowering	0.4	0.7	1.7	0.1	-0.8	0.7	1.3	-0.8	-0.8
Depression (self-reported)	1.1	1.3	3.1	-1.8	0.5	-1.4	0.0	-1.2	-1.0
Medication: Lansoprazole	0.2	0.2	0.7	0.2	-0.5	-0.9	0.4	-0.1	-0.3
Prospective memory result	0.3	0.4	1.4	-0.8	0.3	0.0	-1.2	-0.2	-0.1
Lung cancer (father)	0.4	0.4	1.3	1.1	0.6	-0.1	0.9	-0.3	-0.2
Illnesses of mother	0.4	0.5	1.1	1.0	0.6	0.6	0.8	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	4.4	13.9	22.7	4.0	-3.8	-4.8	2.9	-3.2	-3.4
Pulse wave Arterial Stiffness index	2.5	2.9	12.0	-0.3	1.1	3.5	-1.0	1.2	1.2
Impedance of arm (left)	0.7	3.1	8.2	-2.9	2.5	-0.1	-1.9	0.4	0.5
Arm fat mass (right)	0.1	0.5	1.4	0.8	-0.6	1.2	0.1	0.6	0.6
Trunk predicted mass	0.4	2.0	7.0	2.6	-1.8	-0.9	0.0	-0.7	-0.8
Standing height	0.3	2.6	3.5	1.7	-1.4	-1.9	-1.0	-1.7	-1.8
Length of working week for main job	0.4	0.5	1.6	-1.1	0.1	-1.2	0.0	-0.2	0.0
Exposure to tobacco smoke at home	0.6	0.6	2.2	0.5	-0.6	-1.5	-0.8	-0.3	-0.5
Breastfed as a baby	1.1	1.3	2.1	-1.2	1.1	0.9	-0.7	1.5	1.4
Tense / ‘highly strung’	1.3	2.1	3.8	1.0	-2.0	-1.4	-0.1	-1.7	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.6	-0.6	-0.6	-1.6	-0.5	-0.4	-0.5
Hair/balding pattern: Pattern 4	1.3	3.1	4.6	-2.1	1.2	0.3	-2.1	1.9	2.0
Birth weight of first child	2.3	4.1	6.1	-1.9	2.2	1.9	-0.8	2.5	2.5
Peak expiratory flow (PEF)	0.2	0.4	1.0	1.0	-0.2	-0.7	0.5	0.6	0.5
Pulse wave reflection index	0.1	0.2	0.3	0.5	-0.5	0.0	-0.3	-0.3	-0.4
Ever highly irritable/argumentative for 2 days	1.5	1.8	5.8	-1.2	0.6	1.3	-2.4	0.9	0.9
Loud music exposure frequency	5.0	5.4	16.9	0.5	-1.8	-4.1	2.0	-1.9	-2.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.4	0.2	0.5	-0.6	0.7	0.7
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	7.4	0.8	-1.1	-1.4	1.6	-2.7	-2.6
Blood clot in the leg (DVT)	0.5	0.6	1.5	-1.2	0.8	-0.3	-1.1	-0.3	-0.2
Medication: Paracetamol	0.7	1.1	3.4	-0.7	-0.9	-1.8	-0.5	1.1	0.9
Headache pain in last month	0.3	0.6	1.5	-0.4	-0.6	-1.2	-0.5	-0.7	-0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	-0.0	0.3	-1.1	-0.1	-0.5	-0.5
Glaucoma (self-reported)	0.3	0.3	1.3	0.1	0.2	-1.2	0.6	-0.2	-0.1
Gout (self-reported)	1.0	1.3	4.8	-0.1	-2.2	-0.8	-0.2	-1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	6.8	0.4	0.4	-1.0	2.6	0.3	0.2
Medication: Amlodipine	0.9	1.2	7.1	0.1	0.3	0.4	2.7	-0.0	0.1
Medication: Ventolin 100micrograms inhaler	14.0	18.0	42.6	-4.1	6.5	3.0	-1.4	4.2	4.5
Birth weight	1.2	2.7	10.5	-0.1	1.2	3.2	-1.4	1.1	1.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.4	0.2	0.3	-0.5	0.1	0.0
High blood pressure (siblings)	0.2	0.2	0.5	-0.1	0.1	0.5	0.4	0.7	0.7
Forced vital capacity (FVC), Best measure	2.7	9.8	24.8	2.8	-2.4	-5.0	1.5	-3.0	-3.0
Body fat percentage	0.2	0.7	3.2	0.4	-0.2	1.8	0.1	0.7	0.7
Leg fat percentage (right)	0.3	1.0	4.4	0.3	-0.6	2.1	-0.2	0.8	0.7
Arm fat-free mass (right)	0.6	3.1	10.1	3.2	-2.5	-0.6	0.3	-0.7	-0.9
Exposure to tobacco smoke outside home	1.5	2.0	8.4	-1.3	0.4	-2.9	0.1	-0.9	-1.0
Comparative body size at age 10	1.0	2.9	10.9	0.2	-0.9	3.3	-1.9	1.0	1.0
Number of full brothers	2.2	2.8	6.2	-1.4	1.9	2.5	-0.8	1.4	1.5
Worry too long after embarrassment	0.2	0.4	0.8	0.3	-0.4	-0.5	0.7	-0.9	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.2	-1.0	0.5	-1.8	-0.1	-0.4	-0.3
Wheeze or whistling in the chest in last year	13.3	23.7	32.7	-5.7	5.6	2.0	-3.2	5.6	5.7
Number of children fathered	1.2	1.3	3.0	-0.4	1.0	1.7	-1.3	1.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	7.5	0.8	-1.8	-2.7	1.0	-1.5	-1.6
Age at first live birth	0.4	0.8	2.1	0.3	-0.1	-1.4	0.8	-1.0	-1.0
Pulse wave peak to peak time	2.3	2.8	11.9	0.3	-0.9	-3.4	0.8	-1.3	-1.3
Health satisfaction	0.0	0.0	0.2	0.0	-0.2	0.0	0.5	-0.1	-0.0
Shortness of breath walking on level ground	0.6	0.7	1.3	-1.1	0.7	0.1	-0.7	0.9	1.0
Qualifications: College or University degree	1.8	5.6	16.4	-0.8	-2.4	-4.1	2.2	-1.6	-1.7
Eye problems/disorders: None of the above	5.6	6.5	8.5	-2.7	2.9	2.6	-1.5	2.6	2.7
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.1	-0.5	0.4	2.0	-1.9	1.0	1.0
Emphysema/chronic bronchitis	3.8	4.3	6.0	-2.5	2.4	1.8	-2.2	1.7	1.7
Medication for pain relief, constipation, heartburn	0.3	0.4	1.4	0.6	0.8	1.2	-0.3	-0.4	-0.2
Neck or shoulder pain in last month	0.7	1.0	2.4	-1.6	-0.8	-0.7	-1.3	0.4	0.5
Medication: Blood pressure	0.3	0.5	1.1	-0.2	-0.1	0.6	-0.8	1.0	0.9
Angina (self-reported)	0.3	0.5	1.1	-0.8	-0.5	-0.2	-0.3	-1.1	-0.8
Migraine (self-reported)	0.4	0.5	1.6	-0.5	-0.3	-0.8	-1.3	0.3	0.2
Medication: Ibuprofen	0.3	0.4	0.8	0.5	-0.4	-0.9	0.3	-0.7	-0.8
Medication: Allopurinol	0.5	0.6	2.2	-1.5	-0.8	-0.5	-0.8	0.1	0.2
Medication: Omeprazole	0.9	1.0	2.8	-1.7	-0.7	-0.7	-1.5	-0.1	-0.1
Medication: Seretide 50 evohaler	2.3	2.6	5.9	-0.7	2.4	1.7	0.6	1.7	1.8
Mean time to correctly identify matches	0.9	1.7	3.2	-0.6	0.9	1.8	-0.2	1.7	1.8
Heart disease (mother)	2.6	3.1	8.7	-3.0	1.7	0.3	-1.5	1.6	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	6.4	-1.0	2.0	2.5	-0.2	2.2	2.2
Whole body fat mass	0.2	0.7	2.0	1.0	-0.7	1.4	-0.1	0.6	0.5
Leg fat mass (right)	0.2	0.7	1.5	1.2	-1.0	1.2	-0.0	0.4	0.3
Arm predicted mass (right)	0.7	3.6	12.1	3.5	-2.7	-0.6	0.3	-0.7	-1.0
Pulse rate, automated reading	3.9	12.7	18.7	-4.1	3.5	2.4	-2.2	4.2	4.3
Alcohol intake frequency.	3.4	7.9	15.1	-1.4	3.1	3.9	-1.6	2.9	3.1
Comparative height size at age 10	0.1	0.4	0.9	0.9	-0.1	0.9	0.1	-0.6	-0.6
Number of full sisters	0.4	0.5	1.1	-0.1	0.9	0.4	-0.3	1.1	1.0
Suffer from ‘nerves’	5.1	8.0	13.7	2.3	-3.1	-3.7	1.3	-2.9	-3.0
Overall health rating	0.2	0.5	0.9	-0.9	-0.6	-0.6	-0.1	-1.0	-0.9
Chest pain or discomfort	3.9	5.6	11.6	-3.4	1.9	0.3	-2.0	2.6	2.7
Had major operations	0.8	0.9	3.1	-0.2	1.2	1.8	0.5	0.5	0.6
Age at last live birth	1.3	1.8	3.1	0.8	-0.8	-1.8	1.1	-1.6	-1.7
Family relationship satisfaction	2.4	2.9	4.3	-2.0	1.9	0.3	-1.2	2.0	2.1
Leg pain on walking	0.1	0.2	0.3	0.3	-0.6	-0.5	-0.5	0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	-0.4	0.9	0.4	-1.1	0.4	0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	1.1	1.0	1.1	0.1	0.7	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	-1.1	1.3	0.5	0.1	-0.3	-0.0
Medication: Aspirin	0.2	0.2	0.6	-0.5	0.2	0.3	0.8	0.5	0.4
Supplements: Vitamin C	3.4	4.0	10.1	-1.5	3.2	0.2	-1.8	2.0	2.0
Knee pain experienced in last month	2.6	4.1	8.2	0.5	-2.7	-2.9	-0.5	-2.1	-2.1
Hypertension (Self-reported)	0.2	0.4	1.2	-0.5	-0.3	0.5	-1.1	0.7	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.6	-0.7	0.2	-0.3	-0.3	-0.2
Illnesses of father: Heart disease	2.3	3.2	4.8	-1.8	2.0	1.6	-0.0	2.1	2.2
Illnesses of siblings: Diabetes	1.5	1.9	4.3	-1.1	-0.1	0.8	-2.1	1.6	1.5
Smoking status: Previous	2.5	3.7	5.9	-1.9	1.0	2.0	-1.5	2.3	2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	0.6	0.3	0.7	-0.9	0.4	0.5
Whole body fat-free mass	0.4	2.1	7.5	2.7	-1.9	-0.9	0.2	-0.6	-0.8
Leg fat-free mass (right)	0.5	2.5	7.8	2.8	-1.9	-1.1	0.6	-0.9	-1.1
Arm fat percentage (left)	0.2	0.8	2.1	0.2	0.1	1.4	0.2	1.1	1.1
Average weekly red wine intake	2.6	3.8	7.9	1.7	-2.8	-1.1	0.9	-2.2	-2.3
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.1	-1.5	1.8	1.5	-0.6	1.2	1.2
Mood swings	0.9	1.7	6.4	0.4	-1.5	-2.5	0.2	-0.7	-1.0
Loneliness, isolation	0.6	0.8	2.0	-0.4	-0.4	-0.6	-0.6	-1.4	-1.4
Long-standing illness, disability or infirmity	2.1	3.3	4.8	-2.2	1.8	1.4	-1.4	1.9	2.0
Ever had bowel cancer screening	2.6	3.0	8.0	0.9	-2.8	-1.0	1.4	-1.8	-1.7
Diabetes diagnosed by doctor	2.9	4.7	5.8	-1.8	2.0	2.3	-2.1	2.3	2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	-0.7	1.0	-0.7	-1.2	0.3	0.4
Friendships satisfaction	1.6	2.0	4.9	-1.5	2.2	0.5	0.1	1.4	1.6
Qualifications: nursing, teaching	0.3	0.5	1.0	-0.2	-0.8	0.6	0.2	-1.0	-0.9
Commuting to job workplace: Walk	0.2	0.2	0.9	-1.0	-0.1	0.0	-0.4	-0.1	-0.0
Eye problems/disorders: Cataract	0.2	0.2	0.8	0.6	-0.9	0.2	-0.3	0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	5.4	8.6	20.0	3.4	-4.5	-1.8	2.5	-2.3	-2.3
Medication for cholesterol	1.1	1.7	5.0	1.9	-0.6	-0.6	2.2	-0.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	-1.3	1.3	0.5	-0.8	0.2	0.4
Back pain experienced in last month	0.2	0.3	0.9	-0.8	-0.9	0.4	-0.1	0.4	0.4
Mineral and other dietary supplements	1.2	1.6	6.1	0.7	0.9	2.5	1.0	0.8	0.8
Breast cancer (self-reported)	0.2	0.3	0.7	-0.1	-0.6	-0.8	-0.2	-0.5	-0.4
Asthma (self-reported)	41.8	83.2	176.9	-9.2	13.3	5.3	-2.6	9.8	10.3
Osteoporosis (self-reported)	1.3	1.7	6.2	1.0	-0.8	-2.5	0.3	-0.9	-1.0
Osteoarthritis (self-reported)	0.5	0.6	2.5	-0.4	-0.3	-1.6	0.8	-0.5	-0.3
Medication: Aspirin	0.3	0.4	1.2	-0.4	0.7	0.6	1.1	0.5	0.5
Medication: Gliclazide	2.5	2.8	6.5	0.3	0.6	2.5	-1.4	2.1	1.9
Illnesses of father: None of the above (group 1)	1.3	1.6	3.2	0.7	-1.5	-0.5	-0.0	-1.8	-1.8
Smoking status: Current	2.5	3.9	5.9	-1.9	1.7	2.2	-2.4	1.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	12.3	26.1	31.5	5.3	-4.9	-5.6	4.7	-4.9	-5.2
Whole body water mass	0.4	2.2	6.9	2.6	-2.0	-1.1	0.2	-0.7	-0.9
Leg predicted mass (right)	0.5	2.7	8.2	2.9	-2.0	-1.1	0.7	-1.0	-1.1
Arm fat mass (left)	0.2	0.6	1.3	1.0	-0.8	1.1	0.0	0.7	0.7
Number of self-reported non-cancer illnesses	2.5	4.3	10.0	-2.5	3.2	0.1	-0.2	2.1	2.3
Average weekly champagne plus white wine intake	1.0	1.4	3.3	-0.5	-0.5	-1.8	1.8	-0.8	-0.9
Miserableness	0.5	0.9	3.8	-0.9	0.6	-1.9	0.2	-0.0	-0.1
Guilty feelings	0.5	0.7	1.1	-1.0	0.9	-1.1	0.8	0.7	0.7
Wears glasses or contact lenses	5.1	5.9	10.8	1.5	-3.3	-2.9	1.4	-2.4	-2.5
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.2	-0.1	0.7	-0.3	0.6	0.6
Hearing aid user	0.5	0.6	0.8	0.8	-0.5	0.9	-0.7	-0.9	-0.7
Mother’s age at death	2.9	3.6	9.9	0.4	-1.6	-3.2	2.0	-1.6	-1.5
Financial situation satisfaction	0.6	0.8	2.9	1.2	0.4	0.0	1.7	-0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.9	1.0	4.1	-0.9	0.7	0.7	-2.0	-0.3	-0.2
Commuting to job workplace: Public transport	2.8	3.3	7.7	0.6	-2.6	-2.8	1.0	-1.3	-1.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.4	0.1	-0.1	-0.5	0.5	0.5
Medication: Blood pressure	0.6	1.2	2.7	-1.1	0.4	1.6	-1.1	0.8	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-0.3	-0.9	0.9	-0.3	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	2.3	3.0	9.2	-2.2	0.4	-1.6	-3.0	0.7	0.7
High cholesterol (Self-reported)	0.3	0.6	2.3	-0.1	-0.6	1.5	0.8	0.0	0.1
Medication: Bendroflumethiazide	3.4	5.2	9.7	-1.6	0.2	1.7	-2.7	3.1	2.9
Medication: Paracetamol	0.4	0.6	1.6	-0.3	-1.3	-1.0	-0.4	0.8	0.6
Medication: Lisinopril	1.3	1.6	2.7	1.1	-1.6	-1.0	0.8	-1.4	-1.5
Medication: Atorvastatin	0.5	0.6	1.0	0.6	-0.9	0.3	-1.0	-0.8	-0.8
Illnesses of father: High blood pressure	0.9	1.2	3.1	1.8	-1.4	-0.0	0.1	-0.9	-1.0
Alcohol drinker status: Never	0.3	0.4	1.3	-0.2	0.5	0.4	-1.1	0.6	0.6
Ever smoked	5.6	9.8	12.2	-2.9	2.7	3.5	-3.1	3.2	3.4
Basal metabolic rate	0.3	1.8	6.8	2.6	-1.8	-0.5	0.2	-0.5	-0.6
Leg fat percentage (left)	0.3	1.1	4.6	0.9	-0.9	2.2	0.2	0.5	0.4
Arm fat-free mass (left)	0.4	1.9	6.5	2.5	-1.9	-0.3	0.3	-0.6	-0.7
Number of operations (self-reported)	1.2	1.9	2.7	-1.2	0.6	1.6	-1.6	1.4	1.4
Average weekly beer plus cider intake	1.7	2.5	3.9	1.7	-2.0	-1.1	0.6	-1.7	-1.9
Irritability	0.7	1.1	4.0	0.7	-2.0	-0.8	0.4	-0.9	-0.9
Risk taking	1.1	1.6	5.3	-0.2	-2.0	-2.3	-0.0	-0.2	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.2	0.1	0.9	0.2	0.7	0.7
Fractured/broken bones in last 5 years	0.4	0.5	2.3	-0.5	0.1	-1.5	0.6	-0.4	-0.4
Age started oral contraceptive pill	2.0	2.5	3.5	1.9	-1.6	-1.9	1.3	-1.4	-1.4
Diastolic blood pressure, automated reading	0.2	0.7	1.8	0.1	-0.9	0.0	-0.5	-1.3	-1.2
Ever depressed for a whole week	3.5	4.3	6.5	-2.1	2.3	2.5	-1.2	1.9	2.1
Unable to work because of sickness or disability	0.5	0.7	1.4	-0.8	-0.6	-0.5	-0.6	-1.2	-1.1
Commuting to job workplace: Cycle	0.4	0.5	1.7	-0.1	-1.3	-1.1	-0.2	-0.1	-0.2
Myopia	3.6	5.2	13.5	-1.1	3.7	1.8	0.0	2.6	2.6
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.6	0.5	0.5	-0.5	1.3	-0.1	-0.1
Cholesterol lowering medication	0.8	1.2	2.0	-1.0	1.1	1.4	-1.0	0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.5	-1.7	-0.2	-0.2	-1.9	0.6	0.7
Pain experienced in last month	1.1	1.9	6.0	0.5	2.4	1.6	0.6	1.0	1.1
Supplements: Calcium	1.6	1.8	4.3	0.1	0.1	-2.1	1.4	-1.6	-1.4
Basal cell carcinoma (self-reported)	4.0	4.8	7.8	-2.2	2.0	-0.1	-2.1	2.8	2.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	-0.6	1.1	1.3	-0.1	0.8	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.1	-1.4	1.1	-0.4	-1.1	-0.1	0.0
Heart disease (siblings)	1.8	2.2	4.3	-1.8	0.4	1.6	-2.1	1.1	1.3
Alcohol drinker status: Previous	2.5	2.8	3.7	-1.1	1.6	1.7	-1.7	1.8	1.9
Pack years of smoking	2.4	3.5	13.0	-1.5	0.9	1.4	-3.6	1.3	1.1
Impedance of whole body	0.6	2.9	7.4	-2.7	2.1	1.0	-2.0	0.4	0.4
Leg fat mass (left)	0.2	1.0	2.1	1.5	-1.2	1.4	0.1	0.4	0.3
Arm predicted mass (left)	0.4	1.9	6.8	2.6	-2.0	-0.4	0.3	-0.5	-0.7