TWAS hub - SKIL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.031	0.0160	0.0130	0.002	0.004	-0.002	0.001	-0.002	0.17000	0.0970	0.7000	0.21	0.600
2	TCGA	Lung Adenocarcinoma	0.111	0.0509	0.0013	0.024	0.013	0.020	NA	0.008	0.00078	0.0094	0.0019	NA	0.031

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Prostate Cancer	16.9	23.8	44.5	-1.7	6.7
Diabetes (mother)	4.4	5.6	10.3	-3.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	4.3	4.9	8.6	2.9	1.1
Had menopause	4.1	5.1	10.2	-3.2	-0.1
Tinnitus: Yes, but not now, but have in the past	4.0	4.3	4.3	-2.1	-2.1
Medication: Levothyroxine sodium	3.9	6.6	11.0	-3.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	3.5	5.6	10.5	3.2	0.9
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	5.8	-2.4	-1.6
Birth weight	3.1	6.7	12.3	3.5	1.1
High blood pressure	3.0	8.4	16.0	-4.0	-0.9
Medication: Lisinopril	3.0	3.9	7.7	-2.8	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	3.8	1.9	-1.7
HbA1C	2.7	3.0	5.7	-0.5	2.4
Alzheimer’s Disease (in father)	2.6	2.8	3.4	-1.9	-1.5
Lupus	2.6	3.9	7.3	-0.7	2.7
Stomach or abdominal pain in last month	2.6	3.3	3.8	1.9	1.7
Hypertension (Self-reported)	2.6	7.2	12.6	-3.5	-1.3
Diabetes (self-reported)	2.5	3.8	7.7	-2.8	0.1
Vascular/heart problems diagnosed by doctor	2.5	6.9	13.3	3.6	0.7
Type 2 Diabetes (T2D) (2018)	2.4	4.5	7.8	-2.8	-1.1
Ever used hormone-replacement therapy (HRT)	2.4	3.0	5.4	-2.3	-0.8
Had major operations	2.4	2.8	5.0	-0.7	2.2
Diabetes diagnosed by doctor	2.4	4.0	7.6	-2.8	-0.6
Eye problems/disorders: Diabetes related eye disease	2.2	2.5	2.6	-1.5	-1.6
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	6.5	-2.6	-1.4
Ulcerative Colitis	2.1	3.1	6.2	2.5	0.0
Wears glasses or contact lenses	2.1	2.5	4.8	-2.2	-0.4
Alcohol drinker status: Never	2.1	2.6	3.2	-1.4	1.8
Myopia	2.1	3.0	3.6	1.9	-1.5
Overall health rating	2.0	4.3	6.9	-2.6	-1.3
Number of self-reported non-cancer illnesses	2.0	3.4	6.4	-2.5	-0.7
HDL Cholesterol	1.9	3.1	6.0	2.5	0.4
Neuroticism (2016)	1.9	2.8	3.2	1.8	1.5
Number of incorrect matches in round	1.9	3.2	5.1	-1.1	-2.2
Medication: Blood pressure	1.9	3.4	6.7	-2.6	0.0
Alcohol intake frequency.	1.9	4.3	7.4	-2.7	-1.1
Medication: Metformin	1.8	2.6	4.4	-2.1	-0.9
Arm fat percentage (right)	1.8	7.0	14.0	-0.3	-3.7
Worry too long after embarrassment	1.8	3.0	5.3	2.3	-0.8
Eye problems/disorders: Cataract	1.8	2.1	4.1	-2.0	0.0
Ever taken oral contraceptive pill	1.8	2.0	3.0	-1.0	1.7
Medication: Blood pressure	1.8	3.5	5.5	-2.4	-1.2
Age started oral contraceptive pill	1.8	2.3	3.6	-1.0	-1.9
Severe depression (siblings)	1.7	1.9	3.4	1.9	-0.7
Alcohol intake versus 10 years previously	1.7	2.5	3.3	-1.8	-1.3
Medication: Seretide 50 evohaler	1.7	1.9	2.1	1.4	1.3
Arm fat percentage (left)	1.7	6.8	13.2	-0.6	-3.6
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.8	-0.4	-1.9
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.4	-1.8	0.0
Serious illness, injury or assault to yourself	1.5	1.8	2.3	-1.1	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.5	1.1	-1.6
Cholesterol lowering medication	1.5	2.1	2.2	-1.5	-1.4
Crohns Disease (2012)	1.4	2.2	4.4	-2.1	0.0
LDL Cholesterol	1.4	2.2	4.5	-2.1	0.0
Triglycerides	1.4	2.2	2.8	-1.3	-1.7
Systolic Blood Pressure	1.4	7.0	13.5	-3.7	0.7
Hair/balding pattern: Pattern 3	1.4	2.0	3.7	-1.9	-0.6
Hair/balding pattern: Pattern 4	1.4	3.4	3.9	1.7	-2.0
Body fat percentage	1.4	5.7	10.7	-0.8	-3.3
Eye problems/disorders: None of the above	1.4	1.6	3.1	1.8	-0.4
Irritability	1.4	2.3	2.4	1.5	1.6
Cardiovascular Disease	1.3	4.4	8.7	-3.0	-0.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.5	1.9	0.0
Systolic blood pressure, automated reading	1.3	3.7	7.3	-2.7	-0.3
Trunk fat percentage	1.3	5.3	9.4	-1.1	-3.1
Medication: Atenolol	1.3	1.6	3.1	-1.8	-0.3
Time employed in main current job	1.3	1.5	2.8	1.7	0.4
Noisy workplace	1.3	1.6	1.8	1.1	-1.4
Illnesses of mother	1.3	1.6	2.7	1.6	0.7
Exposure to tobacco smoke at home	1.3	1.5	2.6	-1.6	0.7
Shortness of breath walking on level ground	1.3	1.6	1.9	1.1	-1.4
Medication: Gliclazide	1.3	1.5	2.9	-1.7	-0.3
Guilty feelings	1.3	2.0	4.0	2.0	0.1
Leg fat percentage (left)	1.3	4.6	8.7	-0.6	-3.0
Ever depressed for a whole week	1.3	1.6	2.6	1.6	0.8
Crohns Disease (2017)	1.2	2.7	3.3	-1.5	1.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	1.9	-1.4	-0.9
Waist circumference	1.2	4.5	8.8	0.5	-3.0
Falls in the last year	1.2	1.6	3.1	-1.8	0.0
Arm fat mass (right)	1.2	5.1	10.1	-0.1	-3.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.8	0.3	1.7
Leg fat percentage (right)	1.2	4.5	8.4	-0.8	-2.9
Age at first live birth	1.2	2.2	4.1	2.0	-0.5
Arm fat mass (left)	1.2	5.0	10.0	-0.1	-3.2
Financial situation satisfaction	1.2	1.4	1.7	1.3	1.1
Number of treatments/medications taken	1.1	2.0	3.9	-2.0	0.0
Fed-up feelings	1.1	2.0	3.9	2.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.9	1.7	-0.4
Prospective memory result	1.1	1.4	2.7	0.2	-1.6
Exposure to tobacco smoke outside home	1.1	1.4	2.6	-0.5	1.6
Emphysema/chronic bronchitis	1.1	1.2	2.0	1.4	0.7
Pulse rate, automated reading	1.1	3.5	3.8	-1.8	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.1	-1.5	0.6
Average weekly champagne plus white wine intake	1.1	1.5	2.4	-0.9	1.5
Blood Eosinophil Count	1.0	7.6	14.0	-3.7	1.1
Blood Red Count	1.0	9.7	12.9	-3.6	-2.6
Pulse rate	1.0	1.7	3.1	-0.4	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.3	1.5	-0.5
Medication: Omeprazole	1.0	1.1	2.2	1.5	0.3
Chest pain or discomfort	1.0	1.4	2.6	-0.5	1.6
Illnesses of father: High blood pressure	1.0	1.3	2.3	1.5	0.4
Diastolic blood pressure, automated reading	1.0	3.0	5.6	-2.4	-0.6
Ulcerative Colitis (UC)	0.9	1.6	3.3	1.8	-0.1
Townsend deprivation index at recruitment	0.9	1.3	2.6	-0.2	-1.6
Body mass index (BMI)	0.9	4.0	7.7	0.5	-2.8
Trunk fat mass	0.9	3.8	6.9	-0.9	-2.6
Neuroticism score	0.9	1.8	2.5	1.6	-1.0
Breastfed as a baby	0.9	1.1	1.5	-1.2	-0.8
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.8	1.7	-0.3
Whole body fat mass	0.9	3.8	7.5	-0.3	-2.7
Number of full sisters	0.9	1.0	2.1	0.1	1.4
Illnesses of father: Heart disease	0.9	1.3	2.3	-1.5	0.5
Miserableness	0.9	1.6	3.1	1.8	0.1
High cholesterol (Self-reported)	0.9	1.6	1.6	-1.2	1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.3	-1.5	0.2
Body Mass Index (BMI) (2010)	0.8	1.2	2.3	1.5	0.0
BMI	0.8	4.5	8.8	0.4	-3.0
Pack years adult smoking proportion	0.8	1.2	2.0	1.4	-0.7
Sitting height	0.8	5.4	6.5	-2.1	2.5
High blood pressure (mother)	0.8	1.2	2.1	-1.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	1.6	1.3	-1.0
Heart attack	0.8	1.0	2.1	-1.4	0.2
Pulse wave reflection index	0.8	1.0	1.2	-0.9	1.1
Medication: Paracetamol	0.8	1.3	1.6	1.0	-1.3
Glaucoma (self-reported)	0.8	0.9	1.1	1.0	-0.8
Number of children fathered	0.8	0.9	1.3	-1.1	0.7
Leg fat mass (right)	0.8	3.0	6.0	-0.2	-2.4
Ever had bowel cancer screening	0.8	1.0	1.6	0.5	-1.3
Osteoporosis (self-reported)	0.8	1.0	1.7	1.3	0.6
Medication: Aspirin	0.8	1.0	1.5	0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.3	1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	1.4	0.4
Leg fat mass (left)	0.8	3.2	6.3	-0.2	-2.5
Waist Hip Ratio (WHR)	0.7	3.2	3.3	1.8	-1.7
Diabetes (father)	0.7	0.9	1.1	-1.1	-0.8
Maternal smoking around birth	0.7	1.0	1.9	-0.3	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	1.6	1.3	-1.2
Pain all over the body in last month	0.7	0.7	1.4	0.0	-1.2
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.7	-1.3	-0.5
Happiness	0.7	0.8	1.6	1.3	0.2
Medication: Cholesterol lowering	0.7	1.1	2.0	-0.4	1.4
Lung cancer (father)	0.7	0.8	1.6	-1.3	0.1
Health satisfaction	0.7	0.9	1.1	-1.0	-0.8
Heart disease (mother)	0.7	0.9	1.7	-0.1	1.3
Supplements: Vitamin C	0.7	0.9	1.4	1.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	0.4	1.2
Commuting to job workplace: Walk	0.7	0.8	0.9	-0.9	-0.8
Medication for cholesterol	0.7	1.0	1.5	1.2	0.7
Back pain experienced in last month	0.7	1.0	1.9	0.3	1.4
Medication: Bendroflumethiazide	0.7	1.0	2.0	-1.4	-0.3
Pain experienced in last month	0.7	1.2	2.3	-1.5	-0.3
Pack years of smoking	0.7	1.0	1.6	1.3	-0.6
Depression (Nagel 2018)	0.6	0.9	1.7	1.3	-0.3
Hypothyroidism (self reported)	0.6	1.5	2.9	-1.7	-0.1
Alcohol usually taken with meals	0.6	1.0	2.0	0.0	-1.4
Hip circumference	0.6	2.5	4.8	-0.5	-2.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	1.8	1.0	-1.3
Medication: Lansoprazole	0.6	0.7	1.2	-1.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.3	-1.8	0.6
Neck or shoulder pain in last month	0.6	0.9	1.1	1.0	0.9
Medication: Ibuprofen	0.6	0.7	1.1	1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	1.3	1.1	1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.7	-0.8	0.8
Heel T-Score	0.5	4.3	4.3	2.1	-2.1
Hair Pigment	0.5	13.1	26.1	5.1	-0.2
Average weekly spirits intake	0.5	0.6	0.8	-0.7	-0.9
Age when periods started (menarche)	0.5	1.3	1.9	1.4	0.8
Had other major operations	0.5	0.7	1.3	1.1	0.1
Illnesses of siblings	0.5	0.7	1.3	1.1	0.0
Asthma	0.5	0.9	1.5	-1.2	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.8	-0.9	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	-0.6	1.2
Comparative height size at age 10	0.5	2.7	4.5	-2.1	0.9
Age at last live birth	0.5	0.8	0.9	0.9	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.5	-1.0
Medication: Atorvastatin	0.5	0.6	0.9	-0.6	-0.9
Risk taking	0.5	0.7	1.0	-0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.8	-0.9	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	1.4	0.0
Neuroticism (Nagel 2018)	0.4	0.9	1.8	1.3	0.2
Mean Putamen Volume	0.4	0.5	0.9	0.9	-0.3
Rheumatoid Arthritis	0.4	0.5	1.1	1.0	0.0
Lung FEV1/FVC ratio	0.4	2.1	3.0	-1.7	-1.1
Neuroticism	0.4	0.9	1.1	1.1	-0.9
Sensitivity / hurt feelings	0.4	0.7	1.2	0.3	-1.1
Medication for hormone replacement therapy	0.4	0.4	0.7	0.4	-0.8
Vitamin and mineral supplements	0.4	0.6	0.9	-0.5	-1.0
Supplements: Zinc	0.4	0.4	0.8	0.9	0.2
Current tobacco smoking	0.4	0.6	0.7	0.8	0.7
Relative age voice broke	0.4	0.7	1.1	1.1	-0.5
Taking other prescription medications	0.4	0.6	0.7	-0.7	-0.8
Hair/balding pattern: Pattern 2	0.4	0.4	0.6	0.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.6	0.8	0.7
Medication: Ramipril	0.4	0.5	0.9	-0.9	0.3
Weight	0.4	2.0	4.1	-0.1	-2.0
Loud music exposure frequency	0.4	0.4	0.5	-0.6	-0.7
Blood clot in the leg (DVT)	0.4	0.5	0.5	-0.7	0.7
High blood pressure (siblings)	0.4	0.5	1.0	-1.0	-0.1
Qualifications: College or University degree	0.4	1.1	1.8	1.3	-0.7
Smoking status: Previous	0.4	0.6	0.9	-0.5	1.0
Friendships satisfaction	0.4	0.5	0.5	-0.7	-0.7
Asthma (self-reported)	0.4	0.7	1.3	-1.2	-0.3
Hearing aid user	0.4	0.4	0.5	0.7	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	1.0	0.1
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.3	1.0
Supplements: Calcium	0.4	0.4	0.8	0.9	0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	-1.0	-0.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.4	0.4	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.1	-1.0	-0.4
Age at First Birth	0.3	0.4	0.7	-0.8	-0.5
Smoking Status	0.3	0.6	1.2	-0.1	1.1
Chronotype (morning person)	0.3	0.7	0.9	1.0	0.7
Relative age of first facial hair	0.3	0.7	1.1	0.4	-1.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.8	-0.1
Angina	0.3	0.4	0.6	0.5	0.8
Hand grip strength (right)	0.3	0.9	1.1	1.1	-0.8
Qualifications: CSEs or equivalent	0.3	0.3	0.6	0.3	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	0.9	-0.6
Multivitamins +/- minerals	0.3	0.4	0.8	0.2	0.9
Supplements: Glucosamine	0.3	0.4	0.8	0.0	-0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.4	0.5	-0.6
Past tobacco smoking	0.3	0.6	1.0	0.4	-1.0
Impedance of arm (right)	0.3	1.2	1.9	-1.4	-0.7
Father’s age at death	0.3	0.4	0.8	-0.9	0.2
Number of live births	0.3	0.4	0.7	0.8	0.4
Comparative body size at age 10	0.3	1.0	1.4	1.2	-0.7
Angina (self-reported)	0.3	0.4	0.6	0.4	0.8
Knee pain experienced in last month	0.3	0.5	1.0	-0.1	1.0
Illnesses of siblings: Diabetes	0.3	0.4	0.6	0.2	0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.8	-0.9	0.5
Smoking status: Current	0.3	0.4	0.5	0.6	0.7
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.3	-0.8
Medication: Paracetamol	0.3	0.4	0.5	0.6	-0.7
Ever smoked	0.3	0.5	0.5	-0.7	0.7
Alcohol drinker status: Previous	0.3	0.3	0.5	-0.3	-0.7
Impedance of whole body	0.3	1.6	3.1	-1.8	-0.1
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.7	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.3	-1.1	-0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	-0.4	0.6
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.8	0.0
Blood Platelet Count	0.2	2.0	3.8	-0.5	-1.9
Blood White Count	0.2	1.4	1.5	-1.2	-1.2
Height	0.2	3.0	3.1	-1.8	1.7
Allergy or Eczema	0.2	0.4	0.5	0.6	-0.7
Impedance of leg (right)	0.2	1.2	2.3	-1.5	-0.0
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	0.0
Impedance of leg (left)	0.2	1.1	2.2	-1.5	-0.3
Nervous feelings	0.2	0.4	0.6	0.8	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.4	-0.4	-0.6
Forced vital capacity (FVC)	0.2	0.6	1.2	0.1	1.1
Qualifications: None of the above	0.2	0.4	0.5	0.7	0.5
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.1	-0.7
Mouth/teeth dental problems	0.2	0.3	0.7	0.8	-0.0
Worrier / anxious feelings	0.2	0.4	0.8	0.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.8	-0.6	0.9
Impedance of arm (left)	0.2	1.1	2.2	-1.5	-0.1
Standing height	0.2	2.4	3.0	-1.4	1.7
Length of working week for main job	0.2	0.2	0.3	0.5	0.5
Birth weight of first child	0.2	0.4	0.5	0.6	-0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	-0.5	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.9	1.5	-1.2	0.5
Number of full brothers	0.2	0.3	0.4	-0.4	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.6	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.7	0.0
Qualifications: nursing, teaching	0.2	0.2	0.3	-0.5	0.4
Mineral and other dietary supplements	0.2	0.3	0.6	-0.7	-0.2
Breast cancer (self-reported)	0.2	0.3	0.4	-0.6	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.3	0.5	-0.5
Number of operations (self-reported)	0.2	0.2	0.5	0.1	0.7
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	-0.5	0.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.6	0.0
Worry (Nagel 2018)	0.1	0.2	0.3	-0.3	0.5
Reaction Time	0.1	0.3	0.4	0.7	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.4	0.0
Fasting Glucose	0.1	0.2	0.3	-0.0	0.6
Tanning	0.1	1.5	2.8	-0.5	1.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.5	0.1
Leg fat-free mass (left)	0.1	0.3	0.5	0.7	0.0
Leg predicted mass (left)	0.1	0.3	0.6	0.8	0.1
Medication: Simvastatin	0.1	0.2	0.2	0.4	0.5
Fluid intelligence score	0.1	0.2	0.2	-0.5	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.1	-0.4	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.0	-0.4
Tense / ‘highly strung’	0.1	0.2	0.3	0.5	0.2
Peak expiratory flow (PEF)	0.1	0.3	0.5	0.7	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.4	-0.5
Headache pain in last month	0.1	0.2	0.4	-0.2	0.7
Medication: Amlodipine	0.1	0.1	0.1	-0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.2	0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.2	0.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.5	-0.1
Pulse wave peak to peak time	0.1	0.2	0.3	-0.0	0.6
Migraine (self-reported)	0.1	0.1	0.2	-0.1	-0.5
Mean time to correctly identify matches	0.1	0.1	0.3	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	-0.3	0.5
Medication: Aspirin	0.1	0.2	0.3	0.2	-0.5
Leg fat-free mass (right)	0.1	0.4	0.8	0.9	0.2
Average weekly red wine intake	0.1	0.2	0.3	-0.2	-0.6
Mood swings	0.1	0.2	0.4	-0.1	-0.6
Loneliness, isolation	0.1	0.1	0.2	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.2	0.6
Osteoarthritis (self-reported)	0.1	0.2	0.2	-0.4	-0.4
Leg predicted mass (right)	0.1	0.5	0.8	0.9	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.2	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	-0.3
Commuting to job workplace: Cycle	0.1	0.2	0.2	0.4	-0.5
Heart disease (siblings)	0.1	0.2	0.3	0.2	-0.5
Schizophrenia (2018)	0.0	0.0	0.0	-0.1	0.0
Major Depression (MDD)	0.0	0.1	0.1	0.3	0.0
Breast Cancer	0.0	0.1	0.2	0.1	0.4
Ovarian Cancer	0.0	0.0	0.0	0.0	0.1
Bipolar Disorder (2011)	0.0	0.0	0.1	0.3	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.1	0.0
Respiratory disease	0.0	0.1	0.1	-0.4	0.1
Lung FVC	0.0	0.2	0.3	0.5	0.5
Hand grip strength (left)	0.0	0.1	0.2	0.4	-0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.3	0.1
Medication: Co-codamol	0.0	0.0	0.1	-0.0	0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.2	-0.2
Allergy	0.0	0.0	0.0	0.1	0.2
Trunk fat-free mass	0.0	0.2	0.2	0.4	0.5
Depression (self-reported)	0.0	0.0	0.0	0.1	0.2
Trunk predicted mass	0.0	0.2	0.3	0.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.0	-0.2
Gout (self-reported)	0.0	0.0	0.1	-0.3	-0.0
Arm fat-free mass (right)	0.0	0.1	0.1	0.2	0.3
Medication: Allopurinol	0.0	0.0	0.1	-0.3	-0.1
Arm predicted mass (right)	0.0	0.1	0.2	0.4	0.2
Suffer from ‘nerves’	0.0	0.0	0.1	-0.3	0.1
Family relationship satisfaction	0.0	0.0	0.0	0.1	-0.0
Leg pain on walking	0.0	0.0	0.1	-0.3	-0.1
Whole body fat-free mass	0.0	0.2	0.3	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.2	0.1
Whole body water mass	0.0	0.2	0.2	0.5	0.3
Mother’s age at death	0.0	0.0	0.0	0.1	-0.1
Basal metabolic rate	0.0	0.2	0.2	0.5	-0.3
Arm fat-free mass (left)	0.0	0.1	0.2	0.4	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.0	-0.1	0.1
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	-0.1	-0.3
Arm predicted mass (left)	0.0	0.1	0.1	0.3	-0.3

Hub : Genes

SKIL

Models

Trait associations