Best TWAS P=4.81e-13 · Best GWAS P=2.27e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MDM4 | 0.09 | 0.02 | lasso | 4 | 0.02 | 4.3e-03 | -6.4 | -6.3 | 3.5e-10 | 0.85 | 0.20 | 0.79 | FALSE |
| 2 | GTEx | Esophagus Muscularis | MDM4 | 0.14 | 0.05 | lasso | 4 | 0.05 | 8.6e-04 | -6.4 | -6.6 | 3.0e-11 | 0.84 | 0.10 | 0.88 | FALSE |
| 3 | GTEx | Heart Left Ventricle | NUCKS1 | 0.10 | 0.04 | lasso | 3 | 0.05 | 1.4e-03 | -5.1 | 5.3 | 9.9e-08 | -0.02 | 0.01 | 0.95 | TRUE |
| 4 | GTEx | Nerve Tibial | MDM4 | 0.11 | 0.09 | lasso | 1 | 0.07 | 1.6e-05 | -6.4 | -6.4 | 2.1e-10 | 0.88 | 0.18 | 0.81 | FALSE |
| 5 | GTEx | Testis | PIK3C2B | 0.17 | 0.09 | lasso | 5 | 0.03 | 1.5e-02 | -6.8 | -6.7 | 1.5e-11 | 0.94 | 0.08 | 0.88 | FALSE |
| 6 | YFS | Blood | MDM4 | 0.12 | 0.08 | bslmm | 636 | 0.12 | 2.0e-36 | 4.5 | 6.4 | 1.6e-10 | -0.67 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MDM4 | 0.02 | 0.03 | enet | 4 | 0.03 | 5.5e-04 | -7.3 | -7.2 | 4.8e-13 | 1.00 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | MDM4 | 0.05 | 0.06 | lasso | 1 | 0.04 | 1.6e-04 | -6.4 | -6.4 | 2.1e-10 | 0.88 | 0.21 | 0.76 | FALSE |