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chr5:175,662,866-177,626,134

Best TWAS P=5.57e-37 · Best GWAS P=1.37e-32 conditioned to 0.575

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	The Cancer Genome Atlas	Glioblastoma Multiforme	RGS14	0.22	0.24	blup	39	0.27	6.9e-09	11.67	-12.7	5.6e-37	-0.92	0.01	0.99	TRUE
54	The Cancer Genome Atlas	Thyroid Carcinoma	RGS14	0.26	0.18	lasso	5	0.19	4.5e-18	11.77	-12.0	4.8e-33	-0.96	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS14	0.08	0.10	lasso	2	0.12	1.5e-23	11.77	-11.9	7.0e-33	-0.97	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS14	0.07	0.11	lasso	3	0.10	8.2e-05	11.52	-11.9	9.1e-33	-0.97	0.01	0.97	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS14	0.10	0.07	lasso	2	0.09	3.9e-10	11.67	-11.9	9.2e-33	-0.96	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	RGS14	0.03	0.02	blup	39	0.03	8.1e-05	11.89	-11.9	1.5e-32	-0.90	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RGS14	0.29	0.16	lasso	7	0.20	2.2e-23	10.94	-11.8	5.9e-32	-0.91	0.24	0.76	FALSE
18	GTEx	Esophagus Muscularis	RGS14	0.13	0.12	enet	3	0.15	3.7e-09	10.94	-11.6	2.5e-31	-0.94	0.01	0.99	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	RGS14	0.32	0.35	enet	12	0.38	1.1e-51	11.89	-11.6	4.5e-31	-0.95	0.00	1.00	FALSE
29	GTEx	Testis	RGS14	0.63	0.47	enet	9	0.47	4.8e-23	10.94	-11.4	7.2e-30	-0.93	0.04	0.96	FALSE
23	GTEx	Pancreas	RGS14	0.25	0.12	lasso	13	0.12	1.5e-05	10.40	-11.3	1.4e-29	-0.85	0.07	0.92	FALSE
7	GTEx	Artery Tibial	RGS14	0.49	0.12	enet	10	0.14	6.2e-11	10.94	-11.2	2.5e-29	-0.91	0.09	0.91	FALSE
5	GTEx	Artery Aorta	RGS14	0.35	0.31	lasso	6	0.29	1.5e-16	10.94	-11.2	2.9e-29	-0.89	0.44	0.56	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGS14	0.09	0.08	enet	7	0.10	1.2e-08	10.94	-11.1	8.8e-29	-0.90	0.02	0.98	FALSE
14	GTEx	Cells Transformed fibroblasts	RGS14	0.52	0.39	lasso	6	0.47	4.9e-39	10.94	-11.1	1.5e-28	-0.89	0.99	0.01	FALSE
26	GTEx	Skin Sun Exposed Lower leg	RGS14	0.15	0.16	lasso	3	0.15	9.1e-13	10.94	-11.0	4.1e-28	-0.87	0.70	0.30	FALSE
10	GTEx	Breast Mammary Tissue	RGS14	0.13	0.14	lasso	1	0.11	2.0e-06	10.94	-10.9	7.8e-28	-0.86	0.53	0.32	FALSE
21	GTEx	Lung	RGS14	0.12	0.11	lasso	1	0.08	5.5e-07	10.94	-10.9	7.8e-28	-0.86	0.31	0.69	FALSE
52	The Cancer Genome Atlas	Stomach Adenocarcinoma	RGS14	0.03	0.03	lasso	2	0.04	1.3e-03	10.94	-10.9	9.3e-28	-0.87	0.02	0.80	FALSE
20	GTEx	Heart Left Ventricle	RGS14	0.20	0.11	lasso	2	0.08	3.6e-05	10.94	-10.8	4.0e-27	-0.86	0.10	0.85	FALSE
19	GTEx	Heart Atrial Appendage	RGS14	0.18	0.18	lasso	2	0.20	2.5e-09	10.94	-10.8	4.1e-27	-0.87	0.06	0.94	FALSE
53	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RGS14	0.19	0.03	blup	39	0.03	3.6e-02	11.77	-10.6	1.8e-26	-0.90	0.01	0.81	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RGS14	0.13	0.13	lasso	2	0.14	1.1e-09	10.94	-10.6	2.7e-26	-0.86	0.16	0.84	FALSE
28	GTEx	Stomach	RGS14	0.11	0.17	enet	6	0.17	1.1e-08	9.27	-10.6	3.2e-26	-0.84	0.32	0.66	FALSE
24	GTEx	Pituitary	RGS14	0.48	0.34	lasso	6	0.35	1.4e-09	10.94	-10.5	6.4e-26	-0.86	0.04	0.96	FALSE
22	GTEx	Nerve Tibial	RGS14	0.22	0.10	lasso	6	0.08	1.8e-06	9.27	-10.5	1.4e-25	-0.85	0.29	0.69	FALSE
2	GTEx	Adipose Subcutaneous	RGS14	0.31	0.10	lasso	3	0.10	2.8e-08	9.27	-10.4	1.6e-25	-0.86	0.41	0.59	FALSE
30	GTEx	Thyroid	RGS14	0.15	0.14	enet	9	0.13	2.2e-10	9.27	-10.2	1.8e-24	-0.87	0.10	0.90	FALSE
6	GTEx	Artery Aorta	LMAN2	0.13	0.10	lasso	6	0.06	1.9e-04	10.40	10.2	2.8e-24	0.73	0.54	0.06	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS14	0.08	0.11	lasso	2	0.11	9.4e-07	10.11	-10.2	3.0e-24	-0.87	0.09	0.89	FALSE
16	GTEx	Esophagus Mucosa	RGS14	0.31	0.23	enet	8	0.24	5.2e-16	9.27	-10.1	6.8e-24	-0.85	0.58	0.42	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS14	0.14	0.12	lasso	3	0.13	2.1e-14	9.27	-10.0	1.9e-23	-0.83	0.94	0.06	FALSE
51	The Cancer Genome Atlas	Skin Cutaneous Melanoma	F12	0.15	0.19	lasso	1	0.18	1.1e-05	9.84	-9.8	8.0e-23	-0.76	0.04	0.60	FALSE
4	GTEx	Adrenal Gland	RGS14	0.28	0.24	lasso	4	0.24	3.7e-09	9.27	-9.7	2.0e-22	-0.82	0.48	0.52	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RGS14	0.05	0.03	enet	5	0.05	7.2e-06	10.94	-9.6	9.6e-22	-0.83	0.12	0.83	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS14	0.30	0.18	blup	39	0.25	1.6e-25	9.27	-9.5	2.3e-21	-0.81	0.37	0.63	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	RAB24	0.08	0.04	enet	7	0.06	3.4e-04	9.74	-8.7	2.9e-18	-0.60	0.01	0.72	FALSE
8	GTEx	Brain Cerebellum	RGS14	0.25	0.11	enet	10	0.18	4.8e-06	9.27	-8.5	1.6e-17	-0.75	0.08	0.79	FALSE
32	YFS	Blood	MXD3	0.04	0.03	lasso	4	0.04	5.8e-13	10.66	-8.4	3.4e-17	-0.44	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RGS14	0.19	0.05	enet	16	0.05	6.6e-04	11.89	-8.4	5.0e-17	-0.78	0.00	0.98	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRELID1	0.05	0.00	blup	37	0.03	2.3e-04	-3.19	7.6	2.2e-14	0.60	0.01	0.52	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MXD3	0.05	0.00	lasso	6	0.00	6.9e-01	5.28	7.4	1.4e-13	0.36	0.02	0.09	FALSE
12	GTEx	Breast Mammary Tissue (Female)	MXD3	0.23	0.08	lasso	3	0.09	1.1e-03	-2.70	-7.2	5.6e-13	-0.58	0.07	0.14	FALSE
25	GTEx	Prostate	RGS14	0.59	0.11	enet	39	0.17	4.4e-05	9.27	-7.2	6.3e-13	-0.57	0.03	0.63	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	FGFR4	0.11	0.04	enet	19	0.06	8.7e-07	5.60	-7.2	6.8e-13	-0.37	0.63	0.34	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RGS14	0.12	0.04	lasso	4	0.09	1.2e-03	10.94	-7.2	6.9e-13	-0.63	0.02	0.49	FALSE
3	GTEx	Adipose Subcutaneous	RAB24	0.17	0.08	enet	26	0.14	1.7e-11	-3.15	-6.3	3.3e-10	-0.35	0.99	0.01	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RP11-1277A3.3	0.16	0.04	enet	7	0.06	6.6e-03	1.25	6.2	6.4e-10	0.47	0.05	0.30	FALSE
17	GTEx	Esophagus Muscularis	UIMC1	0.09	0.06	enet	24	0.04	2.3e-03	-2.11	-6.1	1.3e-09	-0.41	0.54	0.20	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	F12	0.05	0.03	enet	4	0.03	4.0e-04	-6.27	-5.8	7.9e-09	-0.23	0.05	0.03	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	F12	0.16	0.06	enet	4	0.11	5.2e-06	-6.17	5.8	8.0e-09	0.23	0.09	0.14	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	MXD3	0.24	0.14	enet	10	0.25	2.9e-07	-0.24	-5.5	3.8e-08	-0.54	0.25	0.14	FALSE
15	GTEx	Colon Transverse	MXD3	0.22	0.09	lasso	5	0.13	8.2e-07	-1.48	-5.5	3.8e-08	-0.41	0.93	0.04	FALSE
27	GTEx	Skin Sun Exposed Lower leg	MXD3	0.19	0.14	lasso	6	0.12	4.2e-10	-2.70	-5.4	7.5e-08	-0.47	1.00	0.00	FALSE