TWAS hub - AGBL3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2890	0.0470	0.0e+00	0.244	0.205	0.237	0.236	0.242	2.0e-29	2.0e-24	1.8e-28	2.3e-28	3.7e-29
2	METSIM	Adipose	0.0510	0.0180	2.9e-04	0.053	0.011	0.020	0.017	0.034	2.0e-08	6.4e-03	4.1e-04	1.2e-03	5.8e-06
3	NTR	Blood	0.0248	0.0084	9.3e-05	0.003	0.012	0.008	0.011	0.006	2.7e-02	8.7e-05	6.8e-04	1.1e-04	4.5e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0736	0.0336	1.5e-05	0.002	0.022	0.012	NA	0.010	1.8e-01	1.5e-03	1.4e-02	NA	2.5e-02
5	TCGA	Brain Lower Grade Glioma	0.0548	0.0270	2.7e-03	0.001	0.008	0.001	NA	0.000	2.2e-01	4.1e-02	2.3e-01	NA	3.1e-01
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.1010	0.0620	8.4e-03	0.027	0.008	0.006	NA	0.010	6.3e-03	8.6e-02	1.2e-01	NA	6.7e-02
7	TCGA	Prostate Adenocarcinoma	0.0788	0.0497	7.6e-03	0.007	0.004	0.005	NA	0.005	5.5e-02	1.0e-01	8.1e-02	NA	9.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2011)	4.1	3.9	7.7	-2.8	-2.2	1.8	1.6	-2.5	-1.0	1.3
Suffer from ‘nerves’	3.6	5.6	20.8	-1.8	1.5	-1.4	-3.3	0.0	4.6	0.5
Diverticular disease/diverticulitis (self-reported)	3.3	4.0	9.4	-0.7	-1.6	2.1	3.1	-1.5	-2.9	0.2
HDL Cholesterol	3.1	5.2	12.4	2.2	3.5	-2.7	-2.0	2.1	1.5	-1.1
Risk taking	2.9	4.3	12.4	-0.5	2.1	-1.3	-3.2	0.9	3.5	0.1
Number of self-reported non-cancer illnesses	2.8	4.8	10.1	-2.1	-3.0	1.6	1.9	-3.2	-2.1	-0.0
Average weekly champagne plus white wine intake	2.8	3.9	8.5	2.9	2.1	-1.5	-1.0	1.8	-0.7	-2.8
Bipolar Disorder or Schizophrenia	2.7	6.6	20.2	-4.5	-2.5	1.1	0.7	-4.2	0.0	0.5
Schizophrenia (2014)	2.4	5.2	14.8	-3.8	-2.2	1.5	0.9	-3.5	-0.5	1.1
Chronic bronchitis/emphysema (father)	2.3	2.7	7.2	-0.8	-2.4	0.5	0.9	-2.7	-2.0	-0.8
Bipolar Disorder (2018)	2.2	3.5	11.2	-3.3	-1.8	1.4	0.8	-2.7	0.4	0.6
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	6.5	-2.5	-0.9	1.8	1.1	-0.8	0.5	2.5
Primary Biliary Cirrhosis	2.1	3.1	5.9	-2.4	-2.4	1.7	0.8	-2.1	0.5	1.2
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	6.8	-2.0	0.0	-1.0	-2.6	-1.6	2.1	-0.2
Medication: Cholesterol lowering	2.1	3.3	6.3	2.5	0.3	-2.2	0.9	0.3	-2.4	-2.3
Number of full brothers	2.1	2.7	9.9	-3.1	-0.2	0.7	-0.3	-1.5	1.6	1.9
Commuting to job workplace: Walk	2.1	2.3	4.9	-2.0	-1.6	1.5	1.2	-0.9	0.6	2.2
Rheumatoid Arthritis	1.9	2.6	5.8	1.4	1.3	-2.0	-2.4	1.3	1.7	-0.4
Lung FEV1/FVC ratio	1.9	9.5	17.6	1.1	3.9	-1.9	-2.4	4.2	4.2	2.4
Medication: Allopurinol	1.9	2.5	6.2	0.6	-1.5	0.5	1.3	-1.5	-2.5	-2.2
Pack years of smoking	1.9	2.8	7.8	-1.8	-1.9	2.8	1.5	-1.2	-1.0	0.7
Ulcerative Colitis (UC)	1.8	3.3	8.3	0.4	1.9	-2.9	-1.7	1.7	2.2	0.7
Ulcerative Colitis	1.8	2.5	7.4	-0.1	1.1	-2.7	-1.9	0.5	2.3	0.2
Pack years adult smoking proportion	1.8	2.8	6.7	-2.2	-1.9	2.6	1.2	-1.3	-0.4	1.2
Had other major operations	1.8	2.2	3.6	-1.2	-1.7	1.2	1.9	-1.8	-1.6	0.4
Illnesses of father: None of the above (group 1)	1.8	2.2	4.2	-1.7	1.6	1.3	-0.3	0.9	1.9	2.1
Tinnitus: Yes, now most or all of the time	1.8	2.1	8.5	0.8	1.3	-2.9	-1.4	0.5	1.3	-0.5
Leg fat percentage (left)	1.8	6.7	17.8	-1.4	-2.7	2.4	4.2	-0.3	-2.0	3.1
Number of operations (self-reported)	1.8	2.7	5.2	-2.3	-1.8	1.8	1.3	-2.2	-0.5	0.5
Lupus	1.7	2.6	4.3	1.7	1.9	-0.5	-1.9	2.1	1.6	-0.9
Chronotype (morning person)	1.7	4.0	9.4	-0.5	-2.7	1.3	0.3	-3.1	-2.1	-2.3
Alcohol drinker status: Never	1.7	2.1	4.3	-1.6	-1.5	2.1	1.2	-0.9	-0.9	1.4
Schizophrenia (2018)	1.6	3.3	10.7	-3.1	-1.7	0.3	0.3	-3.3	-0.3	0.2
Blood Red Count	1.6	15.6	34.1	1.6	5.8	-3.6	-4.9	3.2	4.8	-1.4
Time employed in main current job	1.6	1.9	4.6	-0.4	-2.0	1.2	1.1	-1.3	-2.1	0.2
Loud music exposure frequency	1.6	1.7	4.5	1.6	1.5	-2.1	-0.7	1.2	0.6	-0.4
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	8.4	-1.5	1.1	0.8	-1.9	0.6	2.9	1.6
High blood pressure (siblings)	1.6	2.4	6.3	-0.3	-2.5	1.1	2.1	-1.2	-1.7	0.4
Leg fat percentage (right)	1.6	5.7	13.1	-1.6	-2.7	2.3	3.6	-0.7	-1.7	2.8
Medication: Ibuprofen	1.6	1.9	3.7	-1.6	-0.6	-1.0	-1.9	-1.9	1.5	0.1
Age at last live birth	1.6	2.3	4.2	1.9	1.6	-2.0	-1.2	1.6	1.1	-0.6
Waist Hip Ratio (WHR)	1.5	6.8	14.2	-2.9	-3.8	2.5	1.8	-3.4	-1.6	0.9
Gout (self-reported)	1.5	2.0	6.3	0.9	-0.9	0.3	1.3	-0.9	-2.5	-1.9
Leg fat mass (left)	1.5	5.7	14.7	-1.1	-2.1	3.1	3.8	0.2	-1.5	2.8
Body Mass Index (BMI) (2010)	1.4	1.9	3.7	-0.5	-1.6	1.8	1.6	0.0	-0.9	1.9
Average weekly fortified wine intake	1.4	1.6	5.0	0.2	-0.5	1.0	0.8	-1.2	-1.6	-2.2
Pain all over the body in last month	1.4	1.5	4.5	-1.1	-1.5	-1.1	-0.8	-2.1	0.2	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	8.3	-2.1	-1.2	0.2	1.3	-0.2	0.8	2.9
Birth weight of first child	1.4	2.5	8.6	-2.9	-0.6	0.6	0.3	-0.9	1.6	2.2
Shortness of breath walking on level ground	1.4	1.7	4.3	-0.2	0.7	-2.1	-1.3	0.6	1.9	0.9
Medication: Omeprazole	1.4	1.7	4.8	-2.2	-0.9	1.3	0.0	-0.7	1.0	1.8
Medication: Seretide 50 evohaler	1.4	1.6	4.1	-2.0	-0.8	1.6	0.3	-1.1	-0.2	1.5
Heart disease (mother)	1.4	1.7	4.4	0.7	1.0	0.7	1.2	2.1	0.0	2.1
Reaction Time	1.3	2.5	4.6	-2.1	-2.1	1.5	0.5	-1.9	0.0	1.4
Supplements: Zinc	1.3	1.4	3.0	-1.7	-1.7	0.8	0.0	-0.9	0.8	1.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.8	-0.7	-1.3	0.9	1.7	-0.7	-1.4	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.4	1.6	-0.7	0.5	1.6	1.2	-1.4	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.6	-1.3	0.8	0.0	-1.7	0.8	2.1	1.3
Leg fat mass (right)	1.3	5.1	12.2	-1.1	-2.0	3.0	3.5	0.1	-1.3	2.7
Number of full sisters	1.3	1.6	5.5	1.2	1.5	-0.4	0.3	2.3	1.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	3.6	0.8	1.6	-1.1	-0.5	1.9	1.0	1.3
Guilty feelings	1.3	1.9	4.4	0.5	0.8	-1.6	-1.2	1.7	2.1	1.0
Commuting to job workplace: Public transport	1.3	1.5	2.6	-1.6	-1.5	-0.1	-1.1	-1.6	0.8	1.2
Fractured/broken bones in last 5 years	1.3	1.7	4.8	-0.5	1.0	-1.0	-2.1	0.4	2.2	0.5
Supplements: Calcium	1.3	1.5	3.1	-0.5	-1.6	1.2	0.6	-1.8	-1.4	-0.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.5	-1.3	-1.3	1.9	1.0	-0.5	-0.5	1.6
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.6	-1.8	-0.3	1.7	-0.1	-0.9	0.5	1.9
Medication for hormone replacement therapy	1.2	1.3	2.8	-1.5	-0.2	-1.7	-0.8	-0.9	1.1	1.2
Trunk fat percentage	1.2	4.9	12.3	-0.9	-1.8	2.3	3.5	0.8	-0.9	3.4
Waist circumference	1.2	4.5	9.4	-1.3	-1.9	2.9	2.9	0.3	-0.5	3.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	5.0	-1.4	-0.5	-0.7	-2.2	-0.8	2.0	0.7
Medication: Lansoprazole	1.2	1.4	5.0	0.7	0.2	0.3	2.2	-0.1	-1.9	-0.6
Tense / ‘highly strung’	1.2	2.0	5.6	-1.5	0.0	-0.5	-2.4	-0.8	2.2	0.1
Body fat percentage	1.2	4.8	12.7	-0.9	-1.9	2.1	3.6	0.6	-1.2	3.2
Whole body fat mass	1.2	4.9	12.2	-0.9	-1.7	2.9	3.5	0.6	-1.1	2.9
High cholesterol (Self-reported)	1.2	2.1	5.1	0.7	-1.3	-0.8	1.7	-1.1	-2.3	-1.6
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.9	-1.0	-1.1	1.3	1.2	-0.5	-0.9	1.7
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.0	-1.5	-0.5	-0.3	-1.2	-0.6	2.0	1.7
Medication: Metformin	1.1	1.6	3.8	-1.1	-1.8	1.5	0.8	-0.5	-0.2	2.0
Impedance of leg (right)	1.1	5.2	18.4	-2.3	-3.2	0.4	0.5	-4.3	-1.3	-0.6
Townsend deprivation index at recruitment	1.1	1.5	6.1	-0.9	0.6	-0.6	0.2	0.7	1.6	2.5
Impedance of leg (left)	1.1	5.3	16.7	-2.1	-3.4	0.4	1.2	-4.1	-1.6	-0.5
Trunk fat mass	1.1	4.7	11.4	-0.9	-1.5	2.8	3.4	0.8	-0.6	3.1
Number of incorrect matches in round	1.1	1.9	4.8	-0.6	-2.2	2.0	1.1	-1.4	-0.8	0.3
Mouth/teeth dental problems: Dentures	1.1	1.8	3.8	1.9	0.9	0.6	1.3	0.9	-1.9	-1.1
Prospective memory result	1.1	1.3	4.8	-1.0	-1.2	2.2	0.8	-0.9	-0.1	0.7
Pulse rate, automated reading	1.1	3.4	8.8	-0.8	-3.0	0.1	2.2	-1.8	-2.5	0.2
Alcohol intake frequency.	1.1	2.7	6.6	-2.1	-1.6	2.6	1.3	-1.4	-0.5	1.1
Eye problems/disorders: Cataract	1.1	1.3	2.4	-1.2	-0.9	1.5	1.2	-0.8	-1.1	1.1
Osteoarthritis (self-reported)	1.1	1.4	4.4	1.0	-0.2	0.2	2.1	0.4	-2.0	-0.2
Blood Eosinophil Count	1.0	7.7	20.2	-4.0	-1.0	3.3	1.4	-1.3	1.4	4.5
Systolic Blood Pressure	1.0	4.9	12.2	2.8	-1.8	-0.4	0.8	-1.0	-3.5	-3.0
Allergy or Eczema	1.0	2.6	8.2	-0.5	1.5	-2.9	-1.2	0.8	2.2	0.9
Lung FVC	1.0	5.2	9.5	-1.2	-2.9	3.1	2.8	-1.6	-2.5	0.3
Number of treatments/medications taken	1.0	1.8	5.9	-2.1	-1.4	0.0	0.3	-2.4	-0.2	0.3
Average weekly spirits intake	1.0	1.2	5.4	0.3	0.5	-2.3	-0.8	-0.6	-0.4	-1.3
Vitamin and mineral supplements	1.0	1.4	3.5	1.9	0.8	-0.5	0.2	1.0	-1.0	-1.9
Severe depression (siblings)	1.0	1.2	4.2	0.4	2.1	-1.2	0.7	1.2	-0.1	0.6
Heart attack	1.0	1.2	3.1	1.4	-0.4	-0.2	1.8	0.5	-1.7	-0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	5.9	0.1	1.1	-2.4	-1.1	0.1	0.6	-0.6
Medication: Ramipril	1.0	1.3	2.9	0.5	-1.4	0.5	1.7	0.2	-1.6	0.9
Number of live births	1.0	1.4	4.2	0.9	1.0	-1.4	-2.1	0.5	1.3	-0.2
Medication: Paracetamol	1.0	1.7	4.6	-1.1	-1.8	-2.1	-0.0	-1.6	-0.0	0.4
Medication: Amlodipine	1.0	1.4	3.4	0.2	1.7	1.2	0.6	1.9	0.9	0.7
Mean time to correctly identify matches	1.0	1.9	4.3	-2.1	-1.3	1.5	0.4	-1.5	0.1	1.6
Loneliness, isolation	1.0	1.4	4.9	-2.2	-0.4	0.4	-0.3	-0.9	1.6	1.1
Back pain experienced in last month	1.0	1.4	3.7	-0.4	-0.9	1.3	1.9	-0.7	-1.8	0.2
Hearing aid user	1.0	1.1	3.3	1.4	-0.2	-1.8	-0.0	-0.0	-1.3	-1.0
Basal cell carcinoma (self-reported)	1.0	1.2	3.1	-0.9	1.0	1.2	-0.4	0.7	1.3	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.1	-0.7	-1.7	1.4	0.0	-1.7	-0.3	-0.1
Multivitamins +/- minerals	0.9	1.2	4.6	-1.1	-0.3	1.1	1.0	0.1	0.5	2.1
High blood pressure (mother)	0.9	1.3	3.4	1.7	-0.4	0.0	0.7	0.0	-1.8	-1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.6	-1.9	0.0	-0.6	-0.3	-0.7	1.2	1.2
Birth weight	0.9	1.9	6.6	-1.0	-1.4	0.7	2.6	-0.2	-1.0	1.4
Comparative body size at age 10	0.9	2.4	6.6	-0.3	-1.5	1.5	2.6	-0.6	-2.4	-0.0
Health satisfaction	0.9	1.1	5.9	0.9	0.6	-2.4	-0.5	0.7	0.4	-0.0
Overall health rating	0.9	1.9	5.5	-2.3	-1.5	0.6	-0.1	-1.6	0.9	1.4
Chest pain or discomfort	0.9	1.2	4.2	-2.1	0.6	0.0	-0.3	-0.5	0.9	1.7
Hypertension (Self-reported)	0.9	2.4	6.1	0.8	-2.0	1.5	1.9	-0.3	-2.5	-0.6
Arm fat mass (left)	0.9	3.5	9.5	-0.4	-0.9	2.2	2.7	1.5	-0.3	3.1
Commuting to job workplace: Cycle	0.9	1.1	3.2	-1.8	0.5	1.0	1.4	0.0	0.6	1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.8	1.4	-0.4	-0.4	1.7	0.5	-1.6	-0.3
Fasting Glucose	0.8	0.9	2.7	-0.0	-1.3	0.1	1.6	-0.2	-1.4	0.4
LDL Cholesterol	0.8	1.3	3.9	-1.2	0.6	-0.0	-1.0	0.5	2.0	1.5
Cardiovascular Disease	0.8	2.7	6.7	1.7	-1.5	0.4	1.1	-0.7	-2.6	-2.2
Hypothyroidism (self reported)	0.8	1.8	4.5	-2.1	-1.0	0.9	0.3	-0.4	1.1	2.1
Relative age voice broke	0.8	1.3	2.9	0.8	1.7	-0.7	-1.3	0.5	0.5	-1.7
Body mass index (BMI)	0.8	3.5	7.5	-0.4	-1.1	2.4	2.7	1.2	-0.8	2.7
Alcohol usually taken with meals	0.8	1.3	4.0	0.9	0.5	-1.5	-0.4	-0.3	-1.3	-2.0
Nervous feelings	0.8	1.5	5.2	-0.9	0.3	-1.3	-1.6	-0.2	2.3	0.3
Had menopause	0.8	1.0	3.0	-1.1	-1.0	1.1	0.9	-0.3	-0.2	1.7
Mouth/teeth dental problems	0.8	1.2	3.9	-2.0	-0.1	-0.2	-0.6	-0.7	1.2	1.3
Medication: Simvastatin	0.8	1.2	3.7	1.1	-0.4	-1.1	1.4	-0.1	-1.9	-0.3
Neuroticism score	0.8	1.6	5.4	-1.0	-0.1	-1.3	-1.6	-0.4	2.3	0.7
Weight	0.8	3.8	11.1	-1.0	-1.0	3.3	2.6	0.8	-0.0	2.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.8	-1.9	-1.0	0.7	0.0	-0.7	1.2	2.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.8	1.1	0.6	-0.7	-0.4	0.3	-0.4	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	5.2	-0.4	-0.5	2.3	0.6	-0.1	0.0	0.8
Arm fat percentage (left)	0.8	3.2	11.4	-0.2	-0.5	1.0	2.4	1.9	-0.1	3.4
Qualifications: nursing, teaching	0.8	1.2	2.8	-0.4	-1.2	1.1	1.3	-1.2	-1.7	-0.1
Medication: Lisinopril	0.8	1.0	3.8	0.5	0.3	0.8	0.9	-0.7	-2.0	-0.9
Illnesses of father: High blood pressure	0.8	1.0	2.3	-0.1	-1.5	-0.6	0.6	-1.2	-1.3	-0.9
Irritability	0.8	1.3	4.5	-1.2	0.5	-0.5	-1.0	0.5	2.1	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	5.9	-1.1	1.8	-0.9	-1.9	0.1	2.4	0.5
Cholesterol lowering medication	0.8	1.2	2.6	-0.7	-1.6	0.7	1.6	-0.3	-0.2	1.5
Pain experienced in last month	0.8	1.3	3.8	1.6	1.6	0.1	-0.1	1.9	0.3	0.2
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	-0.5	-1.4	-1.2	0.3	-1.4	-0.1	-0.2
Triglycerides	0.7	1.1	2.2	1.3	-1.0	0.9	0.6	0.2	-1.5	-1.2
Diabetes (father)	0.7	0.9	2.1	0.9	1.1	-1.5	-0.3	1.1	0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.7	1.6	6.3	0.1	0.4	-2.5	-1.4	0.4	1.4	0.5
Diabetes (self-reported)	0.7	1.0	5.3	-0.5	-0.5	0.1	0.1	0.5	1.0	2.3
Arm fat percentage (right)	0.7	2.7	8.8	0.3	-0.6	0.9	2.3	1.9	-0.3	3.0
Depression (self-reported)	0.7	0.8	2.0	-1.2	0.5	1.2	-0.5	0.1	1.4	0.3
Arm fat mass (right)	0.7	3.0	8.1	-0.2	-0.7	2.0	2.4	1.6	-0.2	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.7	-1.2	0.3	0.1	-1.2	0.0	1.9	0.8
Peak expiratory flow (PEF)	0.7	1.7	4.4	1.1	1.4	-0.7	-0.8	2.1	1.6	0.8
Glaucoma (self-reported)	0.7	0.8	1.7	0.9	1.2	-0.4	-0.7	1.3	0.7	-0.7
Number of children fathered	0.7	0.8	2.0	1.3	-0.1	0.4	0.9	0.5	-1.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.5	1.9	-0.1	-0.3	0.6	1.0	-0.9	-0.3
Supplements: Vitamin C	0.7	0.8	1.8	-1.2	-0.8	1.3	-0.6	-0.9	0.3	0.6
Ever had bowel cancer screening	0.7	0.8	2.5	-0.6	-1.6	1.0	0.6	-0.7	-0.0	1.0
Wears glasses or contact lenses	0.7	0.9	1.3	-1.1	-0.7	1.0	1.1	-0.9	-1.0	0.4
Ever taken oral contraceptive pill	0.7	0.8	2.3	-0.5	-0.7	0.2	-0.8	-1.5	0.2	-1.3
Alzheimer’s Disease (in father)	0.6	0.6	3.0	0.6	0.2	-1.7	-0.4	0.7	0.7	0.3
Ovarian Cancer	0.6	0.7	2.2	0.8	1.5	-0.8	-0.3	1.0	0.5	-0.6
Diabetes (mother)	0.6	0.8	1.7	-0.7	-0.7	-1.2	-0.5	-0.1	1.3	1.1
High blood pressure	0.6	1.8	4.2	0.7	-1.8	1.2	1.6	-0.2	-2.0	-0.3
Medication: Atenolol	0.6	0.8	2.0	1.4	0.3	-1.2	0.0	1.1	-0.7	-0.4
Medication: Levothyroxine sodium	0.6	0.9	3.8	-1.0	-1.0	0.2	0.8	0.1	0.4	1.9
Hair/balding pattern: Pattern 2	0.6	0.8	2.5	-0.9	-0.7	0.1	-0.1	0.1	1.2	1.6
Forced vital capacity (FVC)	0.6	2.2	4.3	-1.0	-1.6	2.1	1.7	-1.8	-1.1	-0.7
Pulse rate	0.6	1.1	2.2	0.8	-1.3	-1.5	1.2	0.3	-0.9	0.6
Lung cancer (father)	0.6	0.7	2.0	0.8	0.9	-0.5	-1.4	0.5	0.6	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.9	-1.0	0.7	-0.0	-0.1	-0.1	0.9	1.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.7	-0.8	0.1	-0.2	-1.3	-1.0	1.0	-0.8
Illnesses of siblings: Diabetes	0.6	0.7	2.6	0.6	1.6	-0.5	0.1	0.7	0.7	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.2	-0.3	0.1	-0.3	-1.5	-0.4	1.4	-0.6
Medication for cholesterol	0.6	1.0	4.5	0.5	0.6	-0.4	-0.6	-0.9	-0.7	-2.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	0.4	1.0	-1.0	-0.9	0.7	1.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.4	-0.9	-0.7	1.2	1.0	-0.1	-0.1	1.2
Ever depressed for a whole week	0.6	0.8	2.2	-1.5	-0.5	0.1	-0.8	-0.9	1.1	0.7
Worry (Nagel 2018)	0.5	1.0	3.7	-0.5	0.5	-0.4	-1.5	0.2	1.9	0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	3.2	1.0	-0.5	-1.8	0.0	-0.4	-0.4	-0.5
Irritable Bowel Disease (IBD)	0.5	1.2	4.6	0.6	0.9	-2.2	-1.3	0.6	0.8	-0.1
Major Depression (MDD)	0.5	0.7	1.6	-1.3	-0.8	-0.1	-0.6	-0.8	1.1	0.3
Breast Cancer	0.5	1.2	2.6	-0.3	1.2	-1.5	1.1	1.0	0.2	1.6
Prostate Cancer	0.5	0.6	1.8	0.6	-0.0	0.9	-1.1	-0.2	0.3	-1.4
Age at First Birth	0.5	0.7	1.8	0.2	-0.3	1.0	1.3	0.8	-0.8	0.7
HbA1C	0.5	0.6	1.2	-0.6	-0.7	1.1	0.7	-0.9	-0.8	0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.9	-0.2	-1.7	0.1	0.6	-0.7	-0.6	1.3
Hearing difficulty/problems: Yes	0.5	0.8	1.6	0.2	-0.7	-1.2	0.4	-0.9	-1.3	-1.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	-0.5	0.0	0.9	-1.1	0.4	1.3	0.4
Current tobacco smoking	0.5	0.8	1.7	-1.3	-1.2	-0.3	0.3	-0.6	0.7	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-0.7	-0.4	0.5	-1.2	-1.0	0.7	-0.7
Qualifications: CSEs or equivalent	0.5	0.6	1.1	-0.9	-0.9	0.2	-0.1	-0.9	0.8	1.0
Stomach or abdominal pain in last month	0.5	0.6	2.5	-0.4	-1.6	0.5	-0.1	-1.0	-0.3	-0.3
Allergy	0.5	1.1	3.8	0.3	0.3	1.9	1.1	0.0	-1.2	-0.8
Illnesses of siblings	0.5	0.7	1.9	-1.2	0.1	0.3	-1.4	-0.4	1.1	0.4
Alcohol intake versus 10 years previously	0.5	0.8	3.7	-0.4	-1.9	0.6	0.9	-0.5	-0.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.1	1.5	0.5	-0.6	0.4	1.0	-0.3	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.9	5.3	-1.1	-1.2	2.3	1.9	-1.1	-0.6	-0.1
Arm fat-free mass (right)	0.5	2.6	12.5	-1.0	-0.5	3.5	1.6	0.2	0.3	1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.8	-0.2	-1.1	1.4	0.8	-0.3	-1.0	0.1
Qualifications: College or University degree	0.5	1.7	4.3	-1.5	0.5	-0.8	-1.7	-0.4	2.1	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	1.2	0.4	1.3	0.8	1.1	-0.9	-0.7
Medication: Blood pressure	0.5	0.9	2.9	1.1	-0.4	-0.5	1.1	0.3	-1.7	-0.5
Diabetes diagnosed by doctor	0.5	0.9	3.3	-0.4	-1.2	0.8	0.5	-0.2	0.3	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	1.1	0.7	-0.6	0.3	0.2	-0.6	-1.0
Friendships satisfaction	0.5	0.6	1.2	0.6	1.1	-0.1	-1.1	0.8	0.7	0.4
Breast cancer (self-reported)	0.5	0.6	1.4	-1.1	0.1	0.5	1.1	-0.1	-0.0	1.2
Medication: Gliclazide	0.5	0.6	1.1	-0.9	-0.7	0.9	0.7	-0.4	0.1	1.0
Miserableness	0.5	0.8	2.6	1.6	0.4	-1.0	-0.3	0.8	0.2	-1.2
Medication: Paracetamol	0.5	0.8	4.4	0.0	-0.8	-2.1	0.1	-0.5	-0.1	0.3
Ever smoked	0.5	0.8	2.2	0.3	0.4	-1.5	-1.1	0.6	1.3	0.4
Myopia	0.5	0.8	1.3	-1.0	-1.1	1.1	0.7	-1.1	-0.5	0.3
Heart disease (siblings)	0.5	0.6	1.5	0.8	0.5	1.2	1.0	0.5	-0.7	-0.5
Arm predicted mass (left)	0.5	2.3	12.3	-0.6	-0.7	3.5	1.5	0.0	-0.2	0.7
Heel T-Score	0.4	3.3	15.8	0.0	-0.7	4.0	2.0	-0.0	-1.7	0.0
BMI	0.4	2.4	5.5	-0.9	-1.0	1.9	2.3	0.7	-0.9	2.1
Hand grip strength (left)	0.4	0.9	5.1	-0.4	0.8	2.3	-0.5	0.1	0.6	0.0
Relative age of first facial hair	0.4	0.8	3.3	0.8	0.8	-0.8	-0.5	-0.0	0.3	-1.8
Systolic blood pressure, automated reading	0.4	1.2	3.5	1.6	-0.9	0.4	0.5	-0.1	-1.9	-1.2
Leg fat-free mass (left)	0.4	1.9	6.1	0.2	0.9	2.5	0.8	1.9	1.0	1.1
Fed-up feelings	0.4	0.7	3.1	0.0	-0.0	-1.8	-0.9	-0.1	1.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.6	-0.9	0.8	1.6	0.2	0.8	0.4	1.3
Supplements: Glucosamine	0.4	0.6	1.4	0.7	0.9	-0.4	0.9	1.2	-0.4	0.3
Sitting height	0.4	2.9	13.0	-1.3	-1.3	3.6	1.0	-1.6	-0.4	-0.3
Hearing difficulty/problems with background noise	0.4	0.7	2.7	0.7	0.5	-1.6	0.0	0.2	-0.9	-0.6
Impedance of arm (right)	0.4	1.9	8.3	1.0	0.9	-2.9	-1.4	0.6	0.9	-0.6
Falls in the last year	0.4	0.5	1.0	-1.0	-0.5	0.2	1.0	-0.5	-0.0	1.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	-1.2	0.4	0.4	-0.5	-0.1	0.9	0.7
Impedance of arm (left)	0.4	2.0	8.3	0.3	1.0	-2.9	-1.4	0.5	1.6	0.1
Exposure to tobacco smoke at home	0.4	0.4	1.3	-0.1	1.1	-0.1	-0.7	0.8	0.5	0.4
Pulse wave reflection index	0.4	0.6	1.6	-1.3	0.9	0.2	-0.5	-0.8	0.7	-0.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	0.4	-0.5	-0.3	-0.4	-1.2	-0.9	-1.0
Blood clot in the leg (DVT)	0.4	0.6	1.9	0.1	0.6	-0.2	0.3	1.2	0.3	1.4
Headache pain in last month	0.4	0.7	2.0	-1.2	-0.1	-0.3	-0.9	-0.1	1.4	0.9
Neck or shoulder pain in last month	0.4	0.6	1.7	-1.1	-0.5	-1.3	0.2	-0.7	0.3	0.5
Arm predicted mass (right)	0.4	2.2	11.3	-0.9	-0.5	3.4	1.6	0.0	0.0	0.8
Leg pain on walking	0.4	0.5	1.6	-0.6	-0.2	-0.3	-0.4	0.1	1.3	1.1
Illnesses of father: Heart disease	0.4	0.5	2.1	1.4	-0.0	0.2	0.4	0.9	-0.3	-0.5
Long-standing illness, disability or infirmity	0.4	0.6	2.0	-1.4	-0.5	-0.1	0.1	-1.2	0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.8	0.7	0.0	0.1	-1.7	0.7	1.0	-0.3
Osteoporosis (self-reported)	0.4	0.5	1.8	0.1	0.5	-1.3	-0.2	0.6	0.4	1.0
Medication: Aspirin	0.4	0.5	1.6	0.6	1.0	0.3	0.1	1.2	0.4	0.7
Smoking status: Current	0.4	0.6	1.2	-1.1	-0.9	-0.4	0.0	-0.5	0.9	0.9
Leg predicted mass (right)	0.4	1.9	4.7	0.2	1.1	2.2	0.8	2.1	1.1	1.2
Medication: Blood pressure	0.4	0.8	1.7	0.5	-1.0	1.1	1.3	0.5	-0.9	0.8
Medication: Atorvastatin	0.4	0.5	1.2	-0.8	-1.0	0.7	-0.0	-1.1	0.2	-0.0
Arm fat-free mass (left)	0.4	1.9	10.7	-0.5	-0.4	3.3	1.3	0.1	0.0	0.6
Diastolic blood pressure, automated reading	0.4	1.1	2.9	0.8	-1.2	0.9	0.8	-0.7	-1.7	-1.0
Unable to work because of sickness or disability	0.4	0.6	1.7	-1.2	-0.6	0.6	-0.3	-1.3	0.2	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.2	-0.2	-0.0	0.0	0.8	0.8	-0.0	1.5
Depression (Nagel 2018)	0.3	0.5	1.5	-0.7	-0.8	0.9	0.2	-1.2	-0.1	-0.1
Crohns Disease (2017)	0.3	0.7	1.7	1.0	-0.1	-0.9	-0.6	-0.5	-0.9	-1.3
Neuroticism (2016)	0.3	0.4	1.0	-0.2	-0.2	-0.6	-0.7	0.3	1.0	0.9
Blood Platelet Count	0.3	3.9	10.5	1.7	1.4	-3.2	-2.5	-0.1	0.2	-2.4
Smoking Status	0.3	0.7	1.4	0.2	-1.2	-1.1	-0.0	-1.2	-0.3	-0.9
Tanning	0.3	3.3	5.9	0.9	2.4	-1.8	-2.3	1.5	2.2	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.1	0.8	-0.5	-0.4	-0.3	-0.4	-0.9	-1.1
Angina	0.3	0.4	1.6	-0.1	0.3	-1.3	-0.7	-0.4	0.5	-0.5
Medication: Co-codamol	0.3	0.3	0.9	-0.9	-0.1	0.4	0.9	-0.3	0.3	0.2
Hand grip strength (right)	0.3	0.9	2.9	-0.6	1.1	1.7	-0.8	0.0	1.0	-0.3
Taking other prescription medications	0.3	0.5	1.5	-1.1	-0.7	-0.1	0.0	-1.2	-0.1	-0.0
Leg predicted mass (left)	0.3	1.7	5.6	0.2	1.0	2.4	0.6	1.8	1.0	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	-0.3	0.6	1.3	-0.1	0.9	0.4	1.1
Qualifications: None of the above	0.3	0.7	2.8	1.7	0.2	0.3	-0.1	1.0	-0.6	-0.9
Fluid intelligence score	0.3	0.6	1.9	-1.0	-0.6	-0.6	-0.6	-1.4	0.2	-0.3
Hip circumference	0.3	1.3	2.9	0.3	0.2	1.1	1.4	1.7	0.4	1.7
Father’s age at death	0.3	0.4	1.2	0.7	1.0	-0.1	-1.1	0.6	0.3	-0.1
Worrier / anxious feelings	0.3	0.6	1.4	-0.7	-0.2	-0.7	-0.7	0.1	1.1	1.2
Happiness	0.3	0.3	1.6	0.1	-1.3	0.3	0.2	-0.4	-0.6	0.0
Noisy workplace	0.3	0.3	0.7	0.8	-0.1	-0.8	0.7	0.6	-0.3	0.5
Length of working week for main job	0.3	0.3	0.8	-0.5	0.2	0.9	0.4	0.7	0.3	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	-0.7	-0.3	-0.0	0.8	-0.4	-0.3	1.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.4	-0.6	-0.4	0.8	-0.4	-0.6	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-0.6	-1.3	0.3	0.7	-0.5	0.1	0.7
Pulse wave peak to peak time	0.3	0.4	0.9	0.9	-0.5	-0.2	0.5	-0.1	-0.9	-0.8
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.0	0.6	-0.4	-0.5	0.6	1.1	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.3	-0.8	-0.9	-0.1	-0.2	-1.1	0.1	-0.1
Angina (self-reported)	0.3	0.4	1.3	-0.1	0.2	-1.1	-0.7	-0.7	0.4	-0.6
Comparative height size at age 10	0.3	1.7	6.9	-1.3	-0.2	2.6	0.2	-0.3	1.6	0.8
Had major operations	0.3	0.3	0.8	-0.5	0.3	-0.1	-0.3	0.4	0.9	0.8
Family relationship satisfaction	0.3	0.4	1.3	-0.4	0.5	-0.2	-0.8	-0.0	1.1	0.5
Knee pain experienced in last month	0.3	0.5	1.0	-0.5	-1.0	-0.5	0.7	-0.8	-0.3	0.7
Smoking status: Previous	0.3	0.5	1.5	1.1	-0.1	-0.5	-0.3	-0.3	-0.5	-1.2
Whole body fat-free mass	0.3	1.5	8.4	-0.3	0.5	2.9	0.6	0.8	0.8	0.5
Leg fat-free mass (right)	0.3	1.8	4.2	0.3	1.1	2.1	0.8	2.1	1.1	1.2
Mood swings	0.3	0.6	1.4	-0.3	-1.2	-0.3	-1.1	-0.8	0.9	0.2
Whole body water mass	0.3	1.5	8.2	-0.2	0.5	2.9	0.6	0.9	0.8	0.6
Mother’s age at death	0.3	0.4	1.0	0.5	0.7	-0.1	0.4	-0.2	-1.0	-0.9
Medication: Bendroflumethiazide	0.3	0.4	0.8	0.9	0.4	-0.9	-0.5	0.8	0.4	-0.2
Basal metabolic rate	0.3	1.9	9.2	-0.5	0.1	3.0	1.2	0.9	0.6	1.2
Average weekly beer plus cider intake	0.3	0.4	0.9	0.6	0.3	-0.7	-0.6	0.5	1.0	-0.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	0.1	1.2	0.1	-0.3	0.2	0.5	-0.9
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.1	-1.1	-0.8	-0.2	-0.7	0.3	-0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.4	-0.2	-0.9	-0.9	-0.3	-0.1	0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.4	-0.5	0.4	0.6	-0.3	-0.0	0.8
Crohns Disease (2012)	0.2	0.3	1.0	-1.0	-0.5	0.2	0.6	-0.7	0.2	0.4
Neuroticism	0.2	0.6	1.6	-0.6	-0.5	-0.8	-0.1	-0.1	1.3	1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.1	0.4	-0.6	-0.8	0.3	0.6	0.2
Maternal smoking around birth	0.2	0.3	0.9	-0.5	-0.5	0.2	0.0	-0.3	0.6	0.9
Age when periods started (menarche)	0.2	0.4	1.4	-1.2	-0.3	0.5	-0.2	-1.1	0.1	0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.5	-0.5	0.0	0.5	0.3	-0.2	0.6
Past tobacco smoking	0.2	0.3	0.6	-0.8	0.1	0.6	0.8	0.1	-0.4	0.6
Trunk fat-free mass	0.2	1.4	8.2	-0.5	0.4	2.9	0.3	0.2	0.9	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	0.1	0.1	0.5	0.1	-0.4	-1.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.7	-0.3	-0.2	-0.8	-0.7	-1.3	-0.7	-0.6
Asthma	0.2	0.4	1.1	-0.2	-0.4	-0.9	-1.1	-0.7	0.3	-0.2
Illnesses of mother	0.2	0.3	0.7	-0.4	0.1	0.8	-0.9	-0.5	0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.9	-0.5	-0.1	1.7	1.4	0.2	0.2	0.4
Trunk predicted mass	0.2	1.3	7.5	-0.4	0.5	2.7	0.1	0.3	0.9	0.1
Standing height	0.2	1.8	7.5	-1.5	-0.1	2.7	0.2	-1.0	1.4	-0.1
Worry too long after embarrassment	0.2	0.4	1.0	-1.0	-0.8	0.0	-0.3	-0.9	0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.4	-0.0	0.3	-0.3	0.3	0.4	0.1	1.2
Age at first live birth	0.2	0.4	1.7	0.7	0.6	-1.3	-0.1	0.5	0.5	-0.0
Medication: Aspirin	0.2	0.3	0.8	0.3	0.5	0.6	0.2	0.9	0.2	0.7
Average weekly red wine intake	0.2	0.3	1.1	-0.2	-0.4	-0.4	1.0	-0.5	-0.7	-0.4
Mineral and other dietary supplements	0.2	0.3	0.9	-0.1	-0.3	0.1	-0.7	-0.8	-0.0	-1.0
Asthma (self-reported)	0.2	0.3	0.9	-0.3	-0.4	-0.8	-0.9	-0.6	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	0.6	0.3	0.7	0.7	-0.1	-0.9	-1.1
Financial situation satisfaction	0.2	0.2	0.6	-0.2	-0.6	0.3	-0.1	-0.8	-0.3	-0.5
Alcohol drinker status: Previous	0.2	0.2	1.3	0.3	-0.1	0.0	1.2	0.2	-0.4	-0.1
Impedance of whole body	0.2	1.1	3.5	-1.0	-1.4	-1.2	0.0	-1.9	-0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.8	0.2	-0.7	-0.0	0.3	0.6	0.9
Neuroticism (Nagel 2018)	0.1	0.2	1.0	-0.1	0.1	-0.1	-0.6	0.3	1.0	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.3	0.3	-0.6	-0.3	0.2	-0.4	-0.6
Mean Putamen Volume	0.1	0.1	0.7	-0.0	-0.1	0.1	0.8	-0.3	-0.3	-0.2
Height	0.1	2.7	7.1	-2.0	0.5	2.7	-0.2	-1.0	2.5	0.3
Respiratory disease	0.1	0.3	0.9	-0.7	-0.6	-0.5	-0.5	-0.9	0.0	-0.2
Hair Pigment	0.1	2.2	5.4	2.1	-0.1	-0.4	0.7	-0.1	-2.2	-2.3
Financial difficulties in last 2 years	0.1	0.2	1.0	0.2	-0.1	-1.0	0.3	0.2	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.4	-0.3	-0.1	1.2	0.7	-0.1	0.2	-0.0
Breastfed as a baby	0.1	0.1	0.2	-0.2	-0.2	0.3	-0.4	0.3	0.3	0.4
Hair/balding pattern: Pattern 4	0.1	0.4	1.0	-0.6	-0.3	-0.9	0.5	-1.0	-0.1	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.3	-0.4	-0.0	-0.4	-0.2	0.3	0.4
Migraine (self-reported)	0.1	0.1	0.4	0.0	0.2	0.5	-0.6	-0.3	-0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.1	0.3	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	0.2	-0.2	0.5	0.5	0.2	0.6	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	-0.1	0.7	-0.5	0.4	0.5	0.0	-0.3
Age started oral contraceptive pill	0.1	0.1	0.2	-0.2	-0.5	0.3	-0.2	-0.0	0.1	0.3
Blood White Count	0.0	0.2	0.7	0.8	-0.1	0.1	0.2	0.3	-0.7	-0.5

Hub : Genes

AGBL3

Models

Trait associations