Hub : Genes

AGBL3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2890 0.0470 0.0e+00 0.244 0.205 0.237 0.236 0.242 2.0e-29 2.0e-24 1.8e-28 2.3e-28 3.7e-29
2 METSIM Adipose 0.0510 0.0180 2.9e-04 0.053 0.011 0.020 0.017 0.034 2.0e-08 6.4e-03 4.1e-04 1.2e-03 5.8e-06
3 NTR Blood 0.0248 0.0084 9.3e-05 0.003 0.012 0.008 0.011 0.006 2.7e-02 8.7e-05 6.8e-04 1.1e-04 4.5e-03
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0736 0.0336 1.5e-05 0.002 0.022 0.012 NA 0.010 1.8e-01 1.5e-03 1.4e-02 NA 2.5e-02
5 TCGA Brain Lower Grade Glioma 0.0548 0.0270 2.7e-03 0.001 0.008 0.001 NA 0.000 2.2e-01 4.1e-02 2.3e-01 NA 3.1e-01
6 TCGA Ovarian Serous Cystadenocarcinoma 0.1010 0.0620 8.4e-03 0.027 0.008 0.006 NA 0.010 6.3e-03 8.6e-02 1.2e-01 NA 6.7e-02
7 TCGA Prostate Adenocarcinoma 0.0788 0.0497 7.6e-03 0.007 0.004 0.005 NA 0.005 5.5e-02 1.0e-01 8.1e-02 NA 9.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.2 3.5 11.2 -3.3 -1.8 1.4 0.8 -2.7 0.4 0.6
Bipolar Disorder or Schizophrenia 2.7 6.6 20.2 -4.5 -2.5 1.1 0.7 -4.2 0.0 0.5
Depressed Affect (Nagel 2018) 0.2 0.4 1.2 -0.1 -1.1 -0.8 -0.2 -0.7 0.3 -0.0
Depression (Nagel 2018) 0.3 0.5 1.5 -0.7 -0.8 0.9 0.2 -1.2 -0.1 -0.1
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 -0.8 0.2 -0.7 -0.0 0.3 0.6 0.9
Neuroticism (Nagel 2018) 0.1 0.2 1.0 -0.1 0.1 -0.1 -0.6 0.3 1.0 0.3
Schizophrenia (2018) 1.6 3.3 10.7 -3.1 -1.7 0.3 0.3 -3.3 -0.3 0.2
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 0.4 -0.2 -0.9 -0.9 -0.3 -0.1 0.1
Worry (Nagel 2018) 0.5 1.0 3.7 -0.5 0.5 -0.4 -1.5 0.2 1.9 0.5
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 -0.5 -1.4 -1.2 0.3 -1.4 -0.1 -0.2
Alzheimer’s Disease (in father) 0.6 0.6 3.0 0.6 0.2 -1.7 -0.4 0.7 0.7 0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 3.2 1.0 -0.5 -1.8 0.0 -0.4 -0.4 -0.5
Crohns Disease (2017) 0.3 0.7 1.7 1.0 -0.1 -0.9 -0.6 -0.5 -0.9 -1.3
Irritable Bowel Disease (IBD) 0.5 1.2 4.6 0.6 0.9 -2.2 -1.3 0.6 0.8 -0.1
Ulcerative Colitis (UC) 1.8 3.3 8.3 0.4 1.9 -2.9 -1.7 1.7 2.2 0.7
Major Depression (MDD) 0.5 0.7 1.6 -1.3 -0.8 -0.1 -0.6 -0.8 1.1 0.3
Reaction Time 1.3 2.5 4.6 -2.1 -2.1 1.5 0.5 -1.9 0.0 1.4
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.3 0.3 -0.6 -0.3 0.2 -0.4 -0.6
Breast Cancer 0.5 1.2 2.6 -0.3 1.2 -1.5 1.1 1.0 0.2 1.6
Ovarian Cancer 0.6 0.7 2.2 0.8 1.5 -0.8 -0.3 1.0 0.5 -0.6
Prostate Cancer 0.5 0.6 1.8 0.6 -0.0 0.9 -1.1 -0.2 0.3 -1.4
Age at First Birth 0.5 0.7 1.8 0.2 -0.3 1.0 1.3 0.8 -0.8 0.7
Bipolar Disorder (2011) 4.1 3.9 7.7 -2.8 -2.2 1.8 1.6 -2.5 -1.0 1.3
Body Mass Index (BMI) (2010) 1.4 1.9 3.7 -0.5 -1.6 1.8 1.6 0.0 -0.9 1.9
Coronary Artery Disease (CAD) 0.2 0.2 0.7 -0.4 -0.5 0.4 0.6 -0.3 -0.0 0.8
Crohns Disease (2012) 0.2 0.3 1.0 -1.0 -0.5 0.2 0.6 -0.7 0.2 0.4
Mean Putamen Volume 0.1 0.1 0.7 -0.0 -0.1 0.1 0.8 -0.3 -0.3 -0.2
Fasting Glucose 0.8 0.9 2.7 -0.0 -1.3 0.1 1.6 -0.2 -1.4 0.4
HbA1C 0.5 0.6 1.2 -0.6 -0.7 1.1 0.7 -0.9 -0.8 0.3
HDL Cholesterol 3.1 5.2 12.4 2.2 3.5 -2.7 -2.0 2.1 1.5 -1.1
LDL Cholesterol 0.8 1.3 3.9 -1.2 0.6 -0.0 -1.0 0.5 2.0 1.5
Lupus 1.7 2.6 4.3 1.7 1.9 -0.5 -1.9 2.1 1.6 -0.9
Neuroticism (2016) 0.3 0.4 1.0 -0.2 -0.2 -0.6 -0.7 0.3 1.0 0.9
Primary Biliary Cirrhosis 2.1 3.1 5.9 -2.4 -2.4 1.7 0.8 -2.1 0.5 1.2
Rheumatoid Arthritis 1.9 2.6 5.8 1.4 1.3 -2.0 -2.4 1.3 1.7 -0.4
Schizophrenia (2014) 2.4 5.2 14.8 -3.8 -2.2 1.5 0.9 -3.5 -0.5 1.1
Triglycerides 0.7 1.1 2.2 1.3 -1.0 0.9 0.6 0.2 -1.5 -1.2
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.9 -1.0 -1.1 1.3 1.2 -0.5 -0.9 1.7
Ulcerative Colitis 1.8 2.5 7.4 -0.1 1.1 -2.7 -1.9 0.5 2.3 0.2
Blood Eosinophil Count 1.0 7.7 20.2 -4.0 -1.0 3.3 1.4 -1.3 1.4 4.5
Blood Platelet Count 0.3 3.9 10.5 1.7 1.4 -3.2 -2.5 -0.1 0.2 -2.4
Blood Red Count 1.6 15.6 34.1 1.6 5.8 -3.6 -4.9 3.2 4.8 -1.4
Blood White Count 0.0 0.2 0.7 0.8 -0.1 0.1 0.2 0.3 -0.7 -0.5
Heel T-Score 0.4 3.3 15.8 0.0 -0.7 4.0 2.0 -0.0 -1.7 0.0
BMI 0.4 2.4 5.5 -0.9 -1.0 1.9 2.3 0.7 -0.9 2.1
Height 0.1 2.7 7.1 -2.0 0.5 2.7 -0.2 -1.0 2.5 0.3
Waist Hip Ratio (WHR) 1.5 6.8 14.2 -2.9 -3.8 2.5 1.8 -3.4 -1.6 0.9
Systolic Blood Pressure 1.0 4.9 12.2 2.8 -1.8 -0.4 0.8 -1.0 -3.5 -3.0
Smoking Status 0.3 0.7 1.4 0.2 -1.2 -1.1 -0.0 -1.2 -0.3 -0.9
Allergy or Eczema 1.0 2.6 8.2 -0.5 1.5 -2.9 -1.2 0.8 2.2 0.9
Cardiovascular Disease 0.8 2.7 6.7 1.7 -1.5 0.4 1.1 -0.7 -2.6 -2.2
Hypothyroidism (self reported) 0.8 1.8 4.5 -2.1 -1.0 0.9 0.3 -0.4 1.1 2.1
Respiratory disease 0.1 0.3 0.9 -0.7 -0.6 -0.5 -0.5 -0.9 0.0 -0.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.9 -0.2 -1.7 0.1 0.6 -0.7 -0.6 1.3
Lung FEV1/FVC ratio 1.9 9.5 17.6 1.1 3.9 -1.9 -2.4 4.2 4.2 2.4
Lung FVC 1.0 5.2 9.5 -1.2 -2.9 3.1 2.8 -1.6 -2.5 0.3
Neuroticism 0.2 0.6 1.6 -0.6 -0.5 -0.8 -0.1 -0.1 1.3 1.1
Chronotype (morning person) 1.7 4.0 9.4 -0.5 -2.7 1.3 0.3 -3.1 -2.1 -2.3
Hair Pigment 0.1 2.2 5.4 2.1 -0.1 -0.4 0.7 -0.1 -2.2 -2.3
Tanning 0.3 3.3 5.9 0.9 2.4 -1.8 -2.3 1.5 2.2 -0.7
Hand grip strength (left) 0.4 0.9 5.1 -0.4 0.8 2.3 -0.5 0.1 0.6 0.0
Number of treatments/medications taken 1.0 1.8 5.9 -2.1 -1.4 0.0 0.3 -2.4 -0.2 0.3
Average weekly spirits intake 1.0 1.2 5.4 0.3 0.5 -2.3 -0.8 -0.6 -0.4 -1.3
Sensitivity / hurt feelings 0.3 0.5 1.1 0.8 -0.5 -0.4 -0.3 -0.4 -0.9 -1.1
Frequency of depressed mood in last 2 weeks 1.1 1.6 4.0 -1.5 -0.5 -0.3 -1.2 -0.6 2.0 1.7
Hearing difficulty/problems: Yes 0.5 0.8 1.6 0.2 -0.7 -1.2 0.4 -0.9 -1.3 -1.1
Relative age of first facial hair 0.4 0.8 3.3 0.8 0.8 -0.8 -0.5 -0.0 0.3 -1.8
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 3.5 -1.3 -1.3 1.9 1.0 -0.5 -0.5 1.6
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.6 -1.8 -0.3 1.7 -0.1 -0.9 0.5 1.9
Ever had hysterectomy (womb removed) 0.5 0.6 1.6 -0.5 0.0 0.9 -1.1 0.4 1.3 0.4
Systolic blood pressure, automated reading 0.4 1.2 3.5 1.6 -0.9 0.4 0.5 -0.1 -1.9 -1.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 0.1 0.4 -0.6 -0.8 0.3 0.6 0.2
Angina 0.3 0.4 1.6 -0.1 0.3 -1.3 -0.7 -0.4 0.5 -0.5
Medication for hormone replacement therapy 1.2 1.3 2.8 -1.5 -0.2 -1.7 -0.8 -0.9 1.1 1.2
Vitamin and mineral supplements 1.0 1.4 3.5 1.9 0.8 -0.5 0.2 1.0 -1.0 -1.9
Supplements: Zinc 1.3 1.4 3.0 -1.7 -1.7 0.8 0.0 -0.9 0.8 1.3
Medication: Co-codamol 0.3 0.3 0.9 -0.9 -0.1 0.4 0.9 -0.3 0.3 0.2
Medication: Metformin 1.1 1.6 3.8 -1.1 -1.8 1.5 0.8 -0.5 -0.2 2.0
Diabetes (father) 0.7 0.9 2.1 0.9 1.1 -1.5 -0.3 1.1 0.6 -0.4
Diabetes (mother) 0.6 0.8 1.7 -0.7 -0.7 -1.2 -0.5 -0.1 1.3 1.1
Severe depression (siblings) 1.0 1.2 4.2 0.4 2.1 -1.2 0.7 1.2 -0.1 0.6
Pack years adult smoking proportion 1.8 2.8 6.7 -2.2 -1.9 2.6 1.2 -1.3 -0.4 1.2
Impedance of leg (right) 1.1 5.2 18.4 -2.3 -3.2 0.4 0.5 -4.3 -1.3 -0.6
Leg fat-free mass (left) 0.4 1.9 6.1 0.2 0.9 2.5 0.8 1.9 1.0 1.1
Trunk fat percentage 1.2 4.9 12.3 -0.9 -1.8 2.3 3.5 0.8 -0.9 3.4
Hand grip strength (right) 0.3 0.9 2.9 -0.6 1.1 1.7 -0.8 0.0 1.0 -0.3
Townsend deprivation index at recruitment 1.1 1.5 6.1 -0.9 0.6 -0.6 0.2 0.7 1.6 2.5
Current tobacco smoking 0.5 0.8 1.7 -1.3 -1.2 -0.3 0.3 -0.6 0.7 1.2
Average weekly fortified wine intake 1.4 1.6 5.0 0.2 -0.5 1.0 0.8 -1.2 -1.6 -2.2
Maternal smoking around birth 0.2 0.3 0.9 -0.5 -0.5 0.2 0.0 -0.3 0.6 0.9
Fed-up feelings 0.4 0.7 3.1 0.0 -0.0 -1.8 -0.9 -0.1 1.1 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.1 -0.7 -1.7 1.4 0.0 -1.7 -0.3 -0.1
Relative age voice broke 0.8 1.3 2.9 0.8 1.7 -0.7 -1.3 0.5 0.5 -1.7
Taking other prescription medications 0.3 0.5 1.5 -1.1 -0.7 -0.1 0.0 -1.2 -0.1 -0.0
Age when periods started (menarche) 0.2 0.4 1.4 -1.2 -0.3 0.5 -0.2 -1.1 0.1 0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.4 -0.7 -0.4 0.5 -1.2 -1.0 0.7 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.6 -0.9 0.8 1.6 0.2 0.8 0.4 1.3
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.8 -0.7 -1.3 0.9 1.7 -0.7 -1.4 1.2
Qualifications: CSEs or equivalent 0.5 0.6 1.1 -0.9 -0.9 0.2 -0.1 -0.9 0.8 1.0
Serious illness, injury or assault to yourself 0.2 0.2 0.4 0.5 -0.5 0.0 0.5 0.3 -0.2 0.6
High blood pressure 0.6 1.8 4.2 0.7 -1.8 1.2 1.6 -0.2 -2.0 -0.3
Hayfever, allergic rhinitis or eczema 0.7 1.6 6.3 0.1 0.4 -2.5 -1.4 0.4 1.4 0.5
Multivitamins +/- minerals 0.9 1.2 4.6 -1.1 -0.3 1.1 1.0 0.1 0.5 2.1
Stomach or abdominal pain in last month 0.5 0.6 2.5 -0.4 -1.6 0.5 -0.1 -1.0 -0.3 -0.3
Supplements: Glucosamine 0.4 0.6 1.4 0.7 0.9 -0.4 0.9 1.2 -0.4 0.3
Diverticular disease/diverticulitis (self-reported) 3.3 4.0 9.4 -0.7 -1.6 2.1 3.1 -1.5 -2.9 0.2
Medication: Atenolol 0.6 0.8 2.0 1.4 0.3 -1.2 0.0 1.1 -0.7 -0.4
Medication: Levothyroxine sodium 0.6 0.9 3.8 -1.0 -1.0 0.2 0.8 0.1 0.4 1.9
Sitting height 0.4 2.9 13.0 -1.3 -1.3 3.6 1.0 -1.6 -0.4 -0.3
Chronic bronchitis/emphysema (father) 2.3 2.7 7.2 -0.8 -2.4 0.5 0.9 -2.7 -2.0 -0.8
High blood pressure (mother) 0.9 1.3 3.4 1.7 -0.4 0.0 0.7 0.0 -1.8 -1.6
Body mass index (BMI) 0.8 3.5 7.5 -0.4 -1.1 2.4 2.7 1.2 -0.8 2.7
Impedance of leg (left) 1.1 5.3 16.7 -2.1 -3.4 0.4 1.2 -4.1 -1.6 -0.5
Leg predicted mass (left) 0.3 1.7 5.6 0.2 1.0 2.4 0.6 1.8 1.0 1.0
Trunk fat mass 1.1 4.7 11.4 -0.9 -1.5 2.8 3.4 0.8 -0.6 3.1
Waist circumference 1.2 4.5 9.4 -1.3 -1.9 2.9 2.9 0.3 -0.5 3.1
Number of incorrect matches in round 1.1 1.9 4.8 -0.6 -2.2 2.0 1.1 -1.4 -0.8 0.3
Past tobacco smoking 0.2 0.3 0.6 -0.8 0.1 0.6 0.8 0.1 -0.4 0.6
Alcohol usually taken with meals 0.8 1.3 4.0 0.9 0.5 -1.5 -0.4 -0.3 -1.3 -2.0
Nervous feelings 0.8 1.5 5.2 -0.9 0.3 -1.3 -1.6 -0.2 2.3 0.3
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 5.0 -1.4 -0.5 -0.7 -2.2 -0.8 2.0 0.7
Hearing difficulty/problems with background noise 0.4 0.7 2.7 0.7 0.5 -1.6 0.0 0.2 -0.9 -0.6
Hair/balding pattern: Pattern 2 0.6 0.8 2.5 -0.9 -0.7 0.1 -0.1 0.1 1.2 1.6
Had menopause 0.8 1.0 3.0 -1.1 -1.0 1.1 0.9 -0.3 -0.2 1.7
Had other major operations 1.8 2.2 3.6 -1.2 -1.7 1.2 1.9 -1.8 -1.6 0.4
Forced vital capacity (FVC) 0.6 2.2 4.3 -1.0 -1.6 2.1 1.7 -1.8 -1.1 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.7 -0.3 0.6 1.3 -0.1 0.9 0.4 1.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.6 -1.9 0.0 -0.6 -0.3 -0.7 1.2 1.2
Qualifications: None of the above 0.3 0.7 2.8 1.7 0.2 0.3 -0.1 1.0 -0.6 -0.9
Financial difficulties in last 2 years 0.1 0.2 1.0 0.2 -0.1 -1.0 0.3 0.2 -0.1 -0.1
Mouth/teeth dental problems 0.8 1.2 3.9 -2.0 -0.1 -0.2 -0.6 -0.7 1.2 1.3
Heart attack 1.0 1.2 3.1 1.4 -0.4 -0.2 1.8 0.5 -1.7 -0.4
Allergy 0.5 1.1 3.8 0.3 0.3 1.9 1.1 0.0 -1.2 -0.8
Pain all over the body in last month 1.4 1.5 4.5 -1.1 -1.5 -1.1 -0.8 -2.1 0.2 -0.9
Diabetes (self-reported) 0.7 1.0 5.3 -0.5 -0.5 0.1 0.1 0.5 1.0 2.3
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 5.9 0.1 1.1 -2.4 -1.1 0.1 0.6 -0.6
Medication: Ramipril 1.0 1.3 2.9 0.5 -1.4 0.5 1.7 0.2 -1.6 0.9
Medication: Simvastatin 0.8 1.2 3.7 1.1 -0.4 -1.1 1.4 -0.1 -1.9 -0.3
Fluid intelligence score 0.3 0.6 1.9 -1.0 -0.6 -0.6 -0.6 -1.4 0.2 -0.3
Illnesses of siblings 0.5 0.7 1.9 -1.2 0.1 0.3 -1.4 -0.4 1.1 0.4
Neuroticism score 0.8 1.6 5.4 -1.0 -0.1 -1.3 -1.6 -0.4 2.3 0.7
Weight 0.8 3.8 11.1 -1.0 -1.0 3.3 2.6 0.8 -0.0 2.5
Impedance of arm (right) 0.4 1.9 8.3 1.0 0.9 -2.9 -1.4 0.6 0.9 -0.6
Arm fat percentage (right) 0.7 2.7 8.8 0.3 -0.6 0.9 2.3 1.9 -0.3 3.0
Trunk fat-free mass 0.2 1.4 8.2 -0.5 0.4 2.9 0.3 0.2 0.9 0.2
Hip circumference 0.3 1.3 2.9 0.3 0.2 1.1 1.4 1.7 0.4 1.7
Time employed in main current job 1.6 1.9 4.6 -0.4 -2.0 1.2 1.1 -1.3 -2.1 0.2
Alcohol intake versus 10 years previously 0.5 0.8 3.7 -0.4 -1.9 0.6 0.9 -0.5 -0.2 0.5
Father’s age at death 0.3 0.4 1.2 0.7 1.0 -0.1 -1.1 0.6 0.3 -0.1
Worrier / anxious feelings 0.3 0.6 1.4 -0.7 -0.2 -0.7 -0.7 0.1 1.1 1.2
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 8.3 -2.1 -1.2 0.2 1.3 -0.2 0.8 2.9
Falls in the last year 0.4 0.5 1.0 -1.0 -0.5 0.2 1.0 -0.5 -0.0 1.0
Hair/balding pattern: Pattern 3 0.2 0.3 1.0 0.1 0.1 0.5 0.1 -0.4 -1.0 -1.0
Number of live births 1.0 1.4 4.2 0.9 1.0 -1.4 -2.1 0.5 1.3 -0.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 1.4 -0.3 -0.1 1.2 0.7 -0.1 0.2 -0.0
Pulse rate 0.6 1.1 2.2 0.8 -1.3 -1.5 1.2 0.3 -0.9 0.6
Happiness 0.3 0.3 1.6 0.1 -1.3 0.3 0.2 -0.4 -0.6 0.0
Noisy workplace 0.3 0.3 0.7 0.8 -0.1 -0.8 0.7 0.6 -0.3 0.5
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.7 -0.3 -0.2 -0.8 -0.7 -1.3 -0.7 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.4 1.6 -0.7 0.5 1.6 1.2 -1.4 1.1
Mouth/teeth dental problems: Dentures 1.1 1.8 3.8 1.9 0.9 0.6 1.3 0.9 -1.9 -1.1
Asthma 0.2 0.4 1.1 -0.2 -0.4 -0.9 -1.1 -0.7 0.3 -0.2
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 6.8 -2.0 0.0 -1.0 -2.6 -1.6 2.1 -0.2
Medication: Cholesterol lowering 2.1 3.3 6.3 2.5 0.3 -2.2 0.9 0.3 -2.4 -2.3
Depression (self-reported) 0.7 0.8 2.0 -1.2 0.5 1.2 -0.5 0.1 1.4 0.3
Medication: Lansoprazole 1.2 1.4 5.0 0.7 0.2 0.3 2.2 -0.1 -1.9 -0.6
Prospective memory result 1.1 1.3 4.8 -1.0 -1.2 2.2 0.8 -0.9 -0.1 0.7
Lung cancer (father) 0.6 0.7 2.0 0.8 0.9 -0.5 -1.4 0.5 0.6 -0.9
Illnesses of mother 0.2 0.3 0.7 -0.4 0.1 0.8 -0.9 -0.5 0.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.9 -0.5 -0.1 1.7 1.4 0.2 0.2 0.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 -1.2 0.4 0.4 -0.5 -0.1 0.9 0.7
Impedance of arm (left) 0.4 2.0 8.3 0.3 1.0 -2.9 -1.4 0.5 1.6 0.1
Arm fat mass (right) 0.7 3.0 8.1 -0.2 -0.7 2.0 2.4 1.6 -0.2 2.8
Trunk predicted mass 0.2 1.3 7.5 -0.4 0.5 2.7 0.1 0.3 0.9 0.1
Standing height 0.2 1.8 7.5 -1.5 -0.1 2.7 0.2 -1.0 1.4 -0.1
Length of working week for main job 0.3 0.3 0.8 -0.5 0.2 0.9 0.4 0.7 0.3 0.4
Exposure to tobacco smoke at home 0.4 0.4 1.3 -0.1 1.1 -0.1 -0.7 0.8 0.5 0.4
Breastfed as a baby 0.1 0.1 0.2 -0.2 -0.2 0.3 -0.4 0.3 0.3 0.4
Tense / ‘highly strung’ 1.2 2.0 5.6 -1.5 0.0 -0.5 -2.4 -0.8 2.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.7 -1.2 0.3 0.1 -1.2 0.0 1.9 0.8
Hair/balding pattern: Pattern 4 0.1 0.4 1.0 -0.6 -0.3 -0.9 0.5 -1.0 -0.1 0.3
Birth weight of first child 1.4 2.5 8.6 -2.9 -0.6 0.6 0.3 -0.9 1.6 2.2
Peak expiratory flow (PEF) 0.7 1.7 4.4 1.1 1.4 -0.7 -0.8 2.1 1.6 0.8
Pulse wave reflection index 0.4 0.6 1.6 -1.3 0.9 0.2 -0.5 -0.8 0.7 -0.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.1 -0.7 -0.3 -0.0 0.8 -0.4 -0.3 1.0
Loud music exposure frequency 1.6 1.7 4.5 1.6 1.5 -2.1 -0.7 1.2 0.6 -0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.6 0.4 -0.5 -0.3 -0.4 -1.2 -0.9 -1.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.1 1.5 0.5 -0.6 0.4 1.0 -0.3 -0.6
Blood clot in the leg (DVT) 0.4 0.6 1.9 0.1 0.6 -0.2 0.3 1.2 0.3 1.4
Medication: Paracetamol 1.0 1.7 4.6 -1.1 -1.8 -2.1 -0.0 -1.6 -0.0 0.4
Headache pain in last month 0.4 0.7 2.0 -1.2 -0.1 -0.3 -0.9 -0.1 1.4 0.9
Medication for cholesterol, blood pressure or diabetes 1.6 2.7 8.4 -1.5 1.1 0.8 -1.9 0.6 2.9 1.6
Glaucoma (self-reported) 0.7 0.8 1.7 0.9 1.2 -0.4 -0.7 1.3 0.7 -0.7
Gout (self-reported) 1.5 2.0 6.3 0.9 -0.9 0.3 1.3 -0.9 -2.5 -1.9
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.8 -1.9 -1.0 0.7 0.0 -0.7 1.2 2.0
Medication: Amlodipine 1.0 1.4 3.4 0.2 1.7 1.2 0.6 1.9 0.9 0.7
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.9 -1.0 0.7 -0.0 -0.1 -0.1 0.9 1.7
Birth weight 0.9 1.9 6.6 -1.0 -1.4 0.7 2.6 -0.2 -1.0 1.4
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.8 -0.4 -0.6 -0.4 0.8 -0.4 -0.6 0.9
High blood pressure (siblings) 1.6 2.4 6.3 -0.3 -2.5 1.1 2.1 -1.2 -1.7 0.4
Forced vital capacity (FVC), Best measure 0.5 1.9 5.3 -1.1 -1.2 2.3 1.9 -1.1 -0.6 -0.1
Body fat percentage 1.2 4.8 12.7 -0.9 -1.9 2.1 3.6 0.6 -1.2 3.2
Leg fat percentage (right) 1.6 5.7 13.1 -1.6 -2.7 2.3 3.6 -0.7 -1.7 2.8
Arm fat-free mass (right) 0.5 2.6 12.5 -1.0 -0.5 3.5 1.6 0.2 0.3 1.2
Exposure to tobacco smoke outside home 0.5 0.7 1.8 -0.2 -1.1 1.4 0.8 -0.3 -1.0 0.1
Comparative body size at age 10 0.9 2.4 6.6 -0.3 -1.5 1.5 2.6 -0.6 -2.4 -0.0
Number of full brothers 2.1 2.7 9.9 -3.1 -0.2 0.7 -0.3 -1.5 1.6 1.9
Worry too long after embarrassment 0.2 0.4 1.0 -1.0 -0.8 0.0 -0.3 -0.9 0.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 4.6 -1.3 0.8 0.0 -1.7 0.8 2.1 1.3
Wheeze or whistling in the chest in last year 0.3 0.5 1.6 -0.6 -1.3 0.3 0.7 -0.5 0.1 0.7
Number of children fathered 0.7 0.8 2.0 1.3 -0.1 0.4 0.9 0.5 -1.4 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.4 -0.0 0.3 -0.3 0.3 0.4 0.1 1.2
Age at first live birth 0.2 0.4 1.7 0.7 0.6 -1.3 -0.1 0.5 0.5 -0.0
Pulse wave peak to peak time 0.3 0.4 0.9 0.9 -0.5 -0.2 0.5 -0.1 -0.9 -0.8
Health satisfaction 0.9 1.1 5.9 0.9 0.6 -2.4 -0.5 0.7 0.4 -0.0
Shortness of breath walking on level ground 1.4 1.7 4.3 -0.2 0.7 -2.1 -1.3 0.6 1.9 0.9
Qualifications: College or University degree 0.5 1.7 4.3 -1.5 0.5 -0.8 -1.7 -0.4 2.1 1.0
Eye problems/disorders: None of the above 0.3 0.3 1.2 -0.0 0.6 -0.4 -0.5 0.6 1.1 0.3
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.3 -0.8 -0.9 -0.1 -0.2 -1.1 0.1 -0.1
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.3 -0.4 -0.0 -0.4 -0.2 0.3 0.4
Medication for pain relief, constipation, heartburn 0.5 0.9 1.7 1.2 0.4 1.3 0.8 1.1 -0.9 -0.7
Neck or shoulder pain in last month 0.4 0.6 1.7 -1.1 -0.5 -1.3 0.2 -0.7 0.3 0.5
Medication: Blood pressure 0.5 0.9 2.9 1.1 -0.4 -0.5 1.1 0.3 -1.7 -0.5
Angina (self-reported) 0.3 0.4 1.3 -0.1 0.2 -1.1 -0.7 -0.7 0.4 -0.6
Migraine (self-reported) 0.1 0.1 0.4 0.0 0.2 0.5 -0.6 -0.3 -0.1 -0.0
Medication: Ibuprofen 1.6 1.9 3.7 -1.6 -0.6 -1.0 -1.9 -1.9 1.5 0.1
Medication: Allopurinol 1.9 2.5 6.2 0.6 -1.5 0.5 1.3 -1.5 -2.5 -2.2
Medication: Omeprazole 1.4 1.7 4.8 -2.2 -0.9 1.3 0.0 -0.7 1.0 1.8
Medication: Seretide 50 evohaler 1.4 1.6 4.1 -2.0 -0.8 1.6 0.3 -1.1 -0.2 1.5
Mean time to correctly identify matches 1.0 1.9 4.3 -2.1 -1.3 1.5 0.4 -1.5 0.1 1.6
Heart disease (mother) 1.4 1.7 4.4 0.7 1.0 0.7 1.2 2.1 0.0 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.5 1.9 -0.1 -0.3 0.6 1.0 -0.9 -0.3
Whole body fat mass 1.2 4.9 12.2 -0.9 -1.7 2.9 3.5 0.6 -1.1 2.9
Leg fat mass (right) 1.3 5.1 12.2 -1.1 -2.0 3.0 3.5 0.1 -1.3 2.7
Arm predicted mass (right) 0.4 2.2 11.3 -0.9 -0.5 3.4 1.6 0.0 0.0 0.8
Pulse rate, automated reading 1.1 3.4 8.8 -0.8 -3.0 0.1 2.2 -1.8 -2.5 0.2
Alcohol intake frequency. 1.1 2.7 6.6 -2.1 -1.6 2.6 1.3 -1.4 -0.5 1.1
Comparative height size at age 10 0.3 1.7 6.9 -1.3 -0.2 2.6 0.2 -0.3 1.6 0.8
Number of full sisters 1.3 1.6 5.5 1.2 1.5 -0.4 0.3 2.3 1.0 1.0
Suffer from ‘nerves’ 3.6 5.6 20.8 -1.8 1.5 -1.4 -3.3 0.0 4.6 0.5
Overall health rating 0.9 1.9 5.5 -2.3 -1.5 0.6 -0.1 -1.6 0.9 1.4
Chest pain or discomfort 0.9 1.2 4.2 -2.1 0.6 0.0 -0.3 -0.5 0.9 1.7
Had major operations 0.3 0.3 0.8 -0.5 0.3 -0.1 -0.3 0.4 0.9 0.8
Age at last live birth 1.6 2.3 4.2 1.9 1.6 -2.0 -1.2 1.6 1.1 -0.6
Family relationship satisfaction 0.3 0.4 1.3 -0.4 0.5 -0.2 -0.8 -0.0 1.1 0.5
Leg pain on walking 0.4 0.5 1.6 -0.6 -0.2 -0.3 -0.4 0.1 1.3 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.3 0.1 -0.3 -0.1 0.3 0.5 0.2
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.8 1.1 0.6 -0.7 -0.4 0.3 -0.4 -2.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.7 -0.8 0.1 -0.2 -1.3 -1.0 1.0 -0.8
Medication: Aspirin 0.2 0.3 0.8 0.3 0.5 0.6 0.2 0.9 0.2 0.7
Supplements: Vitamin C 0.7 0.8 1.8 -1.2 -0.8 1.3 -0.6 -0.9 0.3 0.6
Knee pain experienced in last month 0.3 0.5 1.0 -0.5 -1.0 -0.5 0.7 -0.8 -0.3 0.7
Hypertension (Self-reported) 0.9 2.4 6.1 0.8 -2.0 1.5 1.9 -0.3 -2.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 5.2 -0.4 -0.5 2.3 0.6 -0.1 0.0 0.8
Illnesses of father: Heart disease 0.4 0.5 2.1 1.4 -0.0 0.2 0.4 0.9 -0.3 -0.5
Illnesses of siblings: Diabetes 0.6 0.7 2.6 0.6 1.6 -0.5 0.1 0.7 0.7 -0.9
Smoking status: Previous 0.3 0.5 1.5 1.1 -0.1 -0.5 -0.3 -0.3 -0.5 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.4 0.2 -0.2 0.5 0.5 0.2 0.6 0.1
Whole body fat-free mass 0.3 1.5 8.4 -0.3 0.5 2.9 0.6 0.8 0.8 0.5
Leg fat-free mass (right) 0.3 1.8 4.2 0.3 1.1 2.1 0.8 2.1 1.1 1.2
Arm fat percentage (left) 0.8 3.2 11.4 -0.2 -0.5 1.0 2.4 1.9 -0.1 3.4
Average weekly red wine intake 0.2 0.3 1.1 -0.2 -0.4 -0.4 1.0 -0.5 -0.7 -0.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.2 -0.3 0.1 -0.3 -1.5 -0.4 1.4 -0.6
Mood swings 0.3 0.6 1.4 -0.3 -1.2 -0.3 -1.1 -0.8 0.9 0.2
Loneliness, isolation 1.0 1.4 4.9 -2.2 -0.4 0.4 -0.3 -0.9 1.6 1.1
Long-standing illness, disability or infirmity 0.4 0.6 2.0 -1.4 -0.5 -0.1 0.1 -1.2 0.1 0.5
Ever had bowel cancer screening 0.7 0.8 2.5 -0.6 -1.6 1.0 0.6 -0.7 -0.0 1.0
Diabetes diagnosed by doctor 0.5 0.9 3.3 -0.4 -1.2 0.8 0.5 -0.2 0.3 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.2 1.1 0.7 -0.6 0.3 0.2 -0.6 -1.0
Friendships satisfaction 0.5 0.6 1.2 0.6 1.1 -0.1 -1.1 0.8 0.7 0.4
Qualifications: nursing, teaching 0.8 1.2 2.8 -0.4 -1.2 1.1 1.3 -1.2 -1.7 -0.1
Commuting to job workplace: Walk 2.1 2.3 4.9 -2.0 -1.6 1.5 1.2 -0.9 0.6 2.2
Eye problems/disorders: Cataract 1.1 1.3 2.4 -1.2 -0.9 1.5 1.2 -0.8 -1.1 1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.8 0.7 0.0 0.1 -1.7 0.7 1.0 -0.3
Medication for cholesterol 0.6 1.0 4.5 0.5 0.6 -0.4 -0.6 -0.9 -0.7 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 3.6 0.8 1.6 -1.1 -0.5 1.9 1.0 1.3
Back pain experienced in last month 1.0 1.4 3.7 -0.4 -0.9 1.3 1.9 -0.7 -1.8 0.2
Mineral and other dietary supplements 0.2 0.3 0.9 -0.1 -0.3 0.1 -0.7 -0.8 -0.0 -1.0
Breast cancer (self-reported) 0.5 0.6 1.4 -1.1 0.1 0.5 1.1 -0.1 -0.0 1.2
Asthma (self-reported) 0.2 0.3 0.9 -0.3 -0.4 -0.8 -0.9 -0.6 0.3 0.2
Osteoporosis (self-reported) 0.4 0.5 1.8 0.1 0.5 -1.3 -0.2 0.6 0.4 1.0
Osteoarthritis (self-reported) 1.1 1.4 4.4 1.0 -0.2 0.2 2.1 0.4 -2.0 -0.2
Medication: Aspirin 0.4 0.5 1.6 0.6 1.0 0.3 0.1 1.2 0.4 0.7
Medication: Gliclazide 0.5 0.6 1.1 -0.9 -0.7 0.9 0.7 -0.4 0.1 1.0
Illnesses of father: None of the above (group 1) 1.8 2.2 4.2 -1.7 1.6 1.3 -0.3 0.9 1.9 2.1
Smoking status: Current 0.4 0.6 1.2 -1.1 -0.9 -0.4 0.0 -0.5 0.9 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 0.6 0.3 0.7 0.7 -0.1 -0.9 -1.1
Whole body water mass 0.3 1.5 8.2 -0.2 0.5 2.9 0.6 0.9 0.8 0.6
Leg predicted mass (right) 0.4 1.9 4.7 0.2 1.1 2.2 0.8 2.1 1.1 1.2
Arm fat mass (left) 0.9 3.5 9.5 -0.4 -0.9 2.2 2.7 1.5 -0.3 3.1
Number of self-reported non-cancer illnesses 2.8 4.8 10.1 -2.1 -3.0 1.6 1.9 -3.2 -2.1 -0.0
Average weekly champagne plus white wine intake 2.8 3.9 8.5 2.9 2.1 -1.5 -1.0 1.8 -0.7 -2.8
Miserableness 0.5 0.8 2.6 1.6 0.4 -1.0 -0.3 0.8 0.2 -1.2
Guilty feelings 1.3 1.9 4.4 0.5 0.8 -1.6 -1.2 1.7 2.1 1.0
Wears glasses or contact lenses 0.7 0.9 1.3 -1.1 -0.7 1.0 1.1 -0.9 -1.0 0.4
Ever taken oral contraceptive pill 0.7 0.8 2.3 -0.5 -0.7 0.2 -0.8 -1.5 0.2 -1.3
Hearing aid user 1.0 1.1 3.3 1.4 -0.2 -1.8 -0.0 -0.0 -1.3 -1.0
Mother’s age at death 0.3 0.4 1.0 0.5 0.7 -0.1 0.4 -0.2 -1.0 -0.9
Financial situation satisfaction 0.2 0.2 0.6 -0.2 -0.6 0.3 -0.1 -0.8 -0.3 -0.5
Tinnitus: Yes, now most or all of the time 1.8 2.1 8.5 0.8 1.3 -2.9 -1.4 0.5 1.3 -0.5
Commuting to job workplace: Public transport 1.3 1.5 2.6 -1.6 -1.5 -0.1 -1.1 -1.6 0.8 1.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.3 0.4 1.0 -1.0 -0.9 0.7 1.1 -0.7
Medication: Blood pressure 0.4 0.8 1.7 0.5 -1.0 1.1 1.3 0.5 -0.9 0.8
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.5 -0.1 0.7 -0.5 0.4 0.5 0.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.4 -0.9 -0.7 1.2 1.0 -0.1 -0.1 1.2
High cholesterol (Self-reported) 1.2 2.1 5.1 0.7 -1.3 -0.8 1.7 -1.1 -2.3 -1.6
Medication: Bendroflumethiazide 0.3 0.4 0.8 0.9 0.4 -0.9 -0.5 0.8 0.4 -0.2
Medication: Paracetamol 0.5 0.8 4.4 0.0 -0.8 -2.1 0.1 -0.5 -0.1 0.3
Medication: Lisinopril 0.8 1.0 3.8 0.5 0.3 0.8 0.9 -0.7 -2.0 -0.9
Medication: Atorvastatin 0.4 0.5 1.2 -0.8 -1.0 0.7 -0.0 -1.1 0.2 -0.0
Illnesses of father: High blood pressure 0.8 1.0 2.3 -0.1 -1.5 -0.6 0.6 -1.2 -1.3 -0.9
Alcohol drinker status: Never 1.7 2.1 4.3 -1.6 -1.5 2.1 1.2 -0.9 -0.9 1.4
Ever smoked 0.5 0.8 2.2 0.3 0.4 -1.5 -1.1 0.6 1.3 0.4
Basal metabolic rate 0.3 1.9 9.2 -0.5 0.1 3.0 1.2 0.9 0.6 1.2
Leg fat percentage (left) 1.8 6.7 17.8 -1.4 -2.7 2.4 4.2 -0.3 -2.0 3.1
Arm fat-free mass (left) 0.4 1.9 10.7 -0.5 -0.4 3.3 1.3 0.1 0.0 0.6
Number of operations (self-reported) 1.8 2.7 5.2 -2.3 -1.8 1.8 1.3 -2.2 -0.5 0.5
Average weekly beer plus cider intake 0.3 0.4 0.9 0.6 0.3 -0.7 -0.6 0.5 1.0 -0.4
Irritability 0.8 1.3 4.5 -1.2 0.5 -0.5 -1.0 0.5 2.1 1.2
Risk taking 2.9 4.3 12.4 -0.5 2.1 -1.3 -3.2 0.9 3.5 0.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.4 0.1 1.2 0.1 -0.3 0.2 0.5 -0.9
Fractured/broken bones in last 5 years 1.3 1.7 4.8 -0.5 1.0 -1.0 -2.1 0.4 2.2 0.5
Age started oral contraceptive pill 0.1 0.1 0.2 -0.2 -0.5 0.3 -0.2 -0.0 0.1 0.3
Diastolic blood pressure, automated reading 0.4 1.1 2.9 0.8 -1.2 0.9 0.8 -0.7 -1.7 -1.0
Ever depressed for a whole week 0.6 0.8 2.2 -1.5 -0.5 0.1 -0.8 -0.9 1.1 0.7
Unable to work because of sickness or disability 0.4 0.6 1.7 -1.2 -0.6 0.6 -0.3 -1.3 0.2 -0.0
Commuting to job workplace: Cycle 0.9 1.1 3.2 -1.8 0.5 1.0 1.4 0.0 0.6 1.1
Myopia 0.5 0.8 1.3 -1.0 -1.1 1.1 0.7 -1.1 -0.5 0.3
Vascular/heart problems diagnosed by doctor 0.8 2.2 5.9 -1.1 1.8 -0.9 -1.9 0.1 2.4 0.5
Cholesterol lowering medication 0.8 1.2 2.6 -0.7 -1.6 0.7 1.6 -0.3 -0.2 1.5
Medication: Omeprazole (e.g. Zanprol) 2.2 2.7 6.5 -2.5 -0.9 1.8 1.1 -0.8 0.5 2.5
Pain experienced in last month 0.8 1.3 3.8 1.6 1.6 0.1 -0.1 1.9 0.3 0.2
Supplements: Calcium 1.3 1.5 3.1 -0.5 -1.6 1.2 0.6 -1.8 -1.4 -0.7
Basal cell carcinoma (self-reported) 1.0 1.2 3.1 -0.9 1.0 1.2 -0.4 0.7 1.3 1.8
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.8 1.4 -0.4 -0.4 1.7 0.5 -1.6 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.2 -0.2 -0.0 0.0 0.8 0.8 -0.0 1.5
Heart disease (siblings) 0.5 0.6 1.5 0.8 0.5 1.2 1.0 0.5 -0.7 -0.5
Alcohol drinker status: Previous 0.2 0.2 1.3 0.3 -0.1 0.0 1.2 0.2 -0.4 -0.1
Pack years of smoking 1.9 2.8 7.8 -1.8 -1.9 2.8 1.5 -1.2 -1.0 0.7
Impedance of whole body 0.2 1.1 3.5 -1.0 -1.4 -1.2 0.0 -1.9 -0.2 -0.1
Leg fat mass (left) 1.5 5.7 14.7 -1.1 -2.1 3.1 3.8 0.2 -1.5 2.8
Arm predicted mass (left) 0.5 2.3 12.3 -0.6 -0.7 3.5 1.5 0.0 -0.2 0.7