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chr7:149,577,591-152,269,523

Best TWAS P=5.29e-25 · Best GWAS P=2.43e-170 conditioned to 1.03e-165

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Thyroid	SMARCD3	0.10	0.01	lasso	3	0.01	3.5e-02	9.4	10.3	5.3e-25	-0.02	0.23	0.03	TRUE
5	GTEx	Esophagus Mucosa	SLC4A2	0.11	0.03	enet	8	0.06	5.1e-05	10.3	10.2	1.3e-24	-0.07	0.01	0.99	TRUE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM176A	0.04	0.01	blup	60	0.04	4.0e-08	1.8	7.2	7.0e-13	0.03	0.02	0.74	TRUE
3	GTEx	Cells Transformed fibroblasts	SMARCD3	0.14	0.09	lasso	5	0.06	2.5e-05	-7.1	-6.0	1.5e-09	-0.05	0.97	0.00	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHPF2	0.07	0.03	blup	51	0.05	8.6e-07	5.4	5.6	2.5e-08	-0.03	0.62	0.03	TRUE
22	YFS	Blood	PRKAG2	0.10	0.08	lasso	6	0.10	5.3e-32	4.9	5.3	8.6e-08	-0.06	1.00	0.00	TRUE
4	GTEx	Colon Transverse	ABCB8	0.17	0.12	lasso	2	0.07	4.8e-04	9.7	9.9	5.2e-23	-0.06	0.04	0.90	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	AGAP3	0.04	0.03	lasso	3	0.02	4.1e-03	9.7	-9.6	1.1e-21	0.05	0.03	0.66	FALSE
6	GTEx	Esophagus Mucosa	ABCB8	0.15	0.10	lasso	6	0.07	1.0e-05	8.9	9.2	5.0e-20	-0.07	0.06	0.94	FALSE
7	GTEx	Heart Atrial Appendage	ABCB8	0.13	-0.01	lasso	4	0.02	4.6e-02	-4.2	9.1	8.5e-20	-0.02	0.02	0.87	FALSE
8	GTEx	Muscle Skeletal	AGAP3	0.10	0.04	lasso	5	0.03	8.5e-04	9.2	-9.0	2.3e-19	0.03	0.06	0.91	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	ABCB8	0.09	0.01	blup	55	0.07	4.7e-07	-4.2	8.8	1.8e-18	0.05	0.06	0.91	FALSE
14	GTEx	Thyroid	ASIC3	0.18	0.12	enet	29	0.12	1.7e-09	9.7	8.7	2.6e-18	-0.09	0.36	0.63	FALSE
16	GTEx	Whole Blood	AGAP3	0.09	0.04	lasso	4	0.03	1.3e-03	9.4	-8.7	2.6e-18	0.03	0.20	0.76	FALSE
10	GTEx	Nerve Tibial	ABCB8	0.23	0.02	enet	17	0.10	8.7e-08	10.6	8.3	1.2e-16	-0.05	0.00	1.00	FALSE
15	GTEx	Uterus	GIMAP4	0.32	-0.01	enet	42	0.02	1.4e-01	3.3	-8.0	1.3e-15	-0.01	0.04	0.34	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	ABCB8	0.07	0.04	enet	11	0.05	1.3e-06	-4.1	7.3	3.1e-13	0.00	0.18	0.40	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM176A	0.22	0.01	blup	60	0.14	1.7e-15	4.2	6.9	4.6e-12	0.03	0.22	0.65	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM176A	0.32	0.09	blup	60	0.11	6.7e-11	2.4	6.8	9.1e-12	-0.02	0.66	0.01	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	RP11-148K1.12	0.17	0.16	lasso	4	0.16	5.2e-20	6.3	6.6	3.3e-11	0.03	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM176B	0.06	0.01	blup	72	0.03	7.7e-05	4.2	6.5	8.6e-11	0.03	0.04	0.44	FALSE
13	GTEx	Thyroid	ABCB8	0.16	0.12	lasso	5	0.14	3.2e-11	-4.1	6.5	1.1e-10	-0.05	0.75	0.25	FALSE
23	YFS	Blood	SLC4A2	0.03	0.02	lasso	4	0.02	1.5e-07	-3.8	6.4	1.2e-10	-0.09	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ABCB8	0.26	0.14	bslmm	554	0.18	1.4e-21	-4.1	6.1	9.0e-10	0.00	1.00	0.00	FALSE
19	METSIM	Adipose	TMEM176A	0.19	0.14	bslmm	531	0.15	2.9e-21	4.2	6.1	1.3e-09	0.08	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM176A	0.09	0.06	blup	60	0.06	2.5e-07	-2.6	6.0	2.8e-09	0.02	0.61	0.02	FALSE
33	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM176A	0.15	0.00	lasso	10	0.02	5.7e-02	4.2	5.8	5.4e-09	0.02	0.01	0.08	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM176B	0.33	0.10	enet	22	0.14	3.2e-13	2.4	5.8	6.5e-09	-0.01	0.64	0.01	FALSE
21	YFS	Blood	ABCF2	0.07	0.05	lasso	2	0.05	2.9e-15	5.8	5.8	7.0e-09	-0.03	1.00	0.00	FALSE
9	GTEx	Nerve Tibial	ABCF2	0.21	0.14	lasso	5	0.14	3.5e-10	5.8	5.8	7.4e-09	-0.03	1.00	0.00	FALSE
18	METSIM	Adipose	AOC1	0.17	0.08	enet	26	0.11	3.2e-16	2.3	5.7	9.4e-09	0.05	1.00	0.00	FALSE
11	GTEx	Thyroid	ABCF2	0.28	0.23	lasso	3	0.22	1.1e-16	5.8	5.7	9.7e-09	-0.03	1.00	0.00	FALSE
17	METSIM	Adipose	ABCF2	0.12	0.07	lasso	3	0.06	9.3e-10	5.6	5.6	2.5e-08	-0.03	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM176B	0.21	0.11	blup	72	0.15	2.4e-16	4.2	5.5	3.6e-08	0.01	0.20	0.68	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM176B	0.08	0.01	blup	72	0.06	1.6e-12	4.5	5.3	1.0e-07	0.00	0.08	0.85	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GIMAP2	0.07	0.00	blup	479	0.02	9.3e-04	-1.4	5.2	2.1e-07	-0.08	0.08	0.16	FALSE
34	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM176B	0.17	0.12	enet	8	0.11	9.4e-05	4.2	5.2	2.6e-07	0.08	0.14	0.41	FALSE