Best TWAS P=5.29e-25 · Best GWAS P=2.43e-170 conditioned to 1.03e-165
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ABCB8 | 0.26 | 0.14 | bslmm | 554 | 0.18 | 1.4e-21 | -4.1 | 6.1 | 9.0e-10 | 0.00 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | GIMAP2 | 0.07 | 0.00 | blup | 479 | 0.02 | 9.3e-04 | -1.4 | 5.2 | 2.1e-07 | -0.08 | 0.08 | 0.16 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | SMARCD3 | 0.14 | 0.09 | lasso | 5 | 0.06 | 2.5e-05 | -7.1 | -6.0 | 1.5e-09 | -0.05 | 0.97 | 0.00 | TRUE |
| 4 | GTEx | Colon Transverse | ABCB8 | 0.17 | 0.12 | lasso | 2 | 0.07 | 4.8e-04 | 9.7 | 9.9 | 5.2e-23 | -0.06 | 0.04 | 0.90 | FALSE |
| 5 | GTEx | Esophagus Mucosa | SLC4A2 | 0.11 | 0.03 | enet | 8 | 0.06 | 5.1e-05 | 10.3 | 10.2 | 1.3e-24 | -0.07 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Esophagus Mucosa | ABCB8 | 0.15 | 0.10 | lasso | 6 | 0.07 | 1.0e-05 | 8.9 | 9.2 | 5.0e-20 | -0.07 | 0.06 | 0.94 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | ABCB8 | 0.13 | -0.01 | lasso | 4 | 0.02 | 4.6e-02 | -4.2 | 9.1 | 8.5e-20 | -0.02 | 0.02 | 0.87 | FALSE |
| 8 | GTEx | Muscle Skeletal | AGAP3 | 0.10 | 0.04 | lasso | 5 | 0.03 | 8.5e-04 | 9.2 | -9.0 | 2.3e-19 | 0.03 | 0.06 | 0.91 | FALSE |
| 9 | GTEx | Nerve Tibial | ABCF2 | 0.21 | 0.14 | lasso | 5 | 0.14 | 3.5e-10 | 5.8 | 5.8 | 7.4e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | ABCB8 | 0.23 | 0.02 | enet | 17 | 0.10 | 8.7e-08 | 10.6 | 8.3 | 1.2e-16 | -0.05 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Thyroid | ABCF2 | 0.28 | 0.23 | lasso | 3 | 0.22 | 1.1e-16 | 5.8 | 5.7 | 9.7e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Thyroid | SMARCD3 | 0.10 | 0.01 | lasso | 3 | 0.01 | 3.5e-02 | 9.4 | 10.3 | 5.3e-25 | -0.02 | 0.23 | 0.03 | TRUE |
| 13 | GTEx | Thyroid | ABCB8 | 0.16 | 0.12 | lasso | 5 | 0.14 | 3.2e-11 | -4.1 | 6.5 | 1.1e-10 | -0.05 | 0.75 | 0.25 | FALSE |
| 14 | GTEx | Thyroid | ASIC3 | 0.18 | 0.12 | enet | 29 | 0.12 | 1.7e-09 | 9.7 | 8.7 | 2.6e-18 | -0.09 | 0.36 | 0.63 | FALSE |
| 15 | GTEx | Uterus | GIMAP4 | 0.32 | -0.01 | enet | 42 | 0.02 | 1.4e-01 | 3.3 | -8.0 | 1.3e-15 | -0.01 | 0.04 | 0.34 | FALSE |
| 16 | GTEx | Whole Blood | AGAP3 | 0.09 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | 9.4 | -8.7 | 2.6e-18 | 0.03 | 0.20 | 0.76 | FALSE |
| 17 | METSIM | Adipose | ABCF2 | 0.12 | 0.07 | lasso | 3 | 0.06 | 9.3e-10 | 5.6 | 5.6 | 2.5e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 18 | METSIM | Adipose | AOC1 | 0.17 | 0.08 | enet | 26 | 0.11 | 3.2e-16 | 2.3 | 5.7 | 9.4e-09 | 0.05 | 1.00 | 0.00 | FALSE |
| 19 | METSIM | Adipose | TMEM176A | 0.19 | 0.14 | bslmm | 531 | 0.15 | 2.9e-21 | 4.2 | 6.1 | 1.3e-09 | 0.08 | 1.00 | 0.00 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | RP11-148K1.12 | 0.17 | 0.16 | lasso | 4 | 0.16 | 5.2e-20 | 6.3 | 6.6 | 3.3e-11 | 0.03 | 1.00 | 0.00 | FALSE |
| 21 | YFS | Blood | ABCF2 | 0.07 | 0.05 | lasso | 2 | 0.05 | 2.9e-15 | 5.8 | 5.8 | 7.0e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 22 | YFS | Blood | PRKAG2 | 0.10 | 0.08 | lasso | 6 | 0.10 | 5.3e-32 | 4.9 | 5.3 | 8.6e-08 | -0.06 | 1.00 | 0.00 | TRUE |
| 23 | YFS | Blood | SLC4A2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 1.5e-07 | -3.8 | 6.4 | 1.2e-10 | -0.09 | 0.04 | 0.96 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM176A | 0.04 | 0.01 | blup | 60 | 0.04 | 4.0e-08 | 1.8 | 7.2 | 7.0e-13 | 0.03 | 0.02 | 0.74 | TRUE |
| 25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM176B | 0.08 | 0.01 | blup | 72 | 0.06 | 1.6e-12 | 4.5 | 5.3 | 1.0e-07 | 0.00 | 0.08 | 0.85 | FALSE |
| 26 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM176A | 0.22 | 0.01 | blup | 60 | 0.14 | 1.7e-15 | 4.2 | 6.9 | 4.6e-12 | 0.03 | 0.22 | 0.65 | FALSE |
| 27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM176B | 0.21 | 0.11 | blup | 72 | 0.15 | 2.4e-16 | 4.2 | 5.5 | 3.6e-08 | 0.01 | 0.20 | 0.68 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHPF2 | 0.07 | 0.03 | blup | 51 | 0.05 | 8.6e-07 | 5.4 | 5.6 | 2.5e-08 | -0.03 | 0.62 | 0.03 | TRUE |
| 29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AGAP3 | 0.04 | 0.03 | lasso | 3 | 0.02 | 4.1e-03 | 9.7 | -9.6 | 1.1e-21 | 0.05 | 0.03 | 0.66 | FALSE |
| 30 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABCB8 | 0.07 | 0.04 | enet | 11 | 0.05 | 1.3e-06 | -4.1 | 7.3 | 3.1e-13 | 0.00 | 0.18 | 0.40 | FALSE |
| 31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM176A | 0.09 | 0.06 | blup | 60 | 0.06 | 2.5e-07 | -2.6 | 6.0 | 2.8e-09 | 0.02 | 0.61 | 0.02 | FALSE |
| 32 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM176B | 0.06 | 0.01 | blup | 72 | 0.03 | 7.7e-05 | 4.2 | 6.5 | 8.6e-11 | 0.03 | 0.04 | 0.44 | FALSE |
| 33 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM176A | 0.15 | 0.00 | lasso | 10 | 0.02 | 5.7e-02 | 4.2 | 5.8 | 5.4e-09 | 0.02 | 0.01 | 0.08 | FALSE |
| 34 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM176B | 0.17 | 0.12 | enet | 8 | 0.11 | 9.4e-05 | 4.2 | 5.2 | 2.6e-07 | 0.08 | 0.14 | 0.41 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | ABCB8 | 0.09 | 0.01 | blup | 55 | 0.07 | 4.7e-07 | -4.2 | 8.8 | 1.8e-18 | 0.05 | 0.06 | 0.91 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM176A | 0.32 | 0.09 | blup | 60 | 0.11 | 6.7e-11 | 2.4 | 6.8 | 9.1e-12 | -0.02 | 0.66 | 0.01 | FALSE |
| 37 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM176B | 0.33 | 0.10 | enet | 22 | 0.14 | 3.2e-13 | 2.4 | 5.8 | 6.5e-09 | -0.01 | 0.64 | 0.01 | FALSE |