Best TWAS P=1.39e-35 · Best GWAS P=3.79e-35 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | LOXL2 | 0.48 | 0.01 | enet | 8 | 0.00 | 3.8e-01 | 8.9 | 10.1 | 7.6e-24 | 0.06 | 0.07 | 0.20 | FALSE |
| 2 | GTEx | Ovary | FGF17 | 0.38 | 0.00 | lasso | 4 | 0.03 | 6.7e-02 | -2.6 | 7.8 | 4.0e-15 | -0.47 | 0.03 | 0.55 | FALSE |
| 3 | NTR | Blood | NKX3-1 | 0.30 | 0.33 | enet | 37 | 0.36 | 6.3e-123 | 7.7 | 8.7 | 5.2e-18 | 0.02 | 1.00 | 0.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SLC25A37 | 0.27 | 0.36 | enet | 12 | 0.37 | 1.5e-49 | -11.0 | 10.5 | 6.4e-26 | 0.08 | 0.02 | 0.98 | TRUE |
| 5 | YFS | Blood | SLC25A37 | 0.10 | 0.06 | bslmm | 575 | 0.09 | 1.2e-26 | -9.3 | 8.7 | 4.5e-18 | 0.06 | 0.05 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC25A37 | 0.13 | 0.00 | blup | 123 | 0.03 | 9.4e-03 | -3.5 | -6.0 | 2.0e-09 | -0.06 | 0.05 | 0.03 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | FGF17 | 0.08 | 0.03 | blup | 45 | 0.05 | 4.4e-06 | -11.6 | 8.8 | 8.7e-19 | -0.65 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | NPM2 | 0.04 | 0.00 | blup | 45 | 0.01 | 1.5e-02 | -0.6 | 6.7 | 1.7e-11 | -0.48 | 0.01 | 0.16 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NPM2 | 0.16 | 0.12 | lasso | 2 | 0.09 | 5.6e-04 | -12.4 | -12.5 | 1.4e-35 | 1.00 | 0.00 | 0.98 | TRUE |