Hub : Genes

NPM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3510	0.0820	6.1e-05	0.228	NA	0.270	NA	0.229	2.3e-07	NA	1.3e-08	NA	2.1e-07
2	TCGA	Esophageal Carcinoma	0.1710	0.0850	8.8e-03	-0.004	0.007	0.021	NA	-0.004	4.7e-01	0.1900	7.1e-02	NA	4.7e-01
3	TCGA	Lung Adenocarcinoma	0.0448	0.0264	4.8e-03	-0.001	0.011	0.002	NA	0.003	4.1e-01	0.0150	1.6e-01	NA	1.4e-01
4	TCGA	Testicular Germ Cell Tumors	0.1570	0.0750	9.3e-03	0.118	0.064	0.069	NA	0.087	5.8e-05	0.0028	2.0e-03	NA	5.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.5	-0.3	-0.6	0.9
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.2	-0.4	-0.2	0.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.8	-0.5	-0.0	0.9
Depression (Nagel 2018)	0.6	0.9	2.2	-1.5	-1.0	-0.4	0.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	-1.3	-0.9	1.0	-0.7
Neuroticism (Nagel 2018)	0.5	1.2	2.5	-0.6	-1.6	-0.3	1.3
Schizophrenia (2018)	0.0	0.1	0.2	0.2	-0.2	0.3	-0.4
Schizophrenia vs Biploar Disorder	1.8	2.4	8.0	0.9	0.0	2.8	-0.9
Worry (Nagel 2018)	0.6	1.2	2.1	-0.8	-1.3	-0.6	1.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.4	-0.7	0.2	0.6
Alzheimer’s Disease (in father)	1.5	1.7	4.7	-1.4	-2.2	-0.0	0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	2.6	-0.6	-1.6	-0.2	0.5
Crohns Disease (2017)	1.4	3.1	8.6	2.9	1.2	0.3	-1.6
Irritable Bowel Disease (IBD)	1.4	3.3	10.9	3.3	1.0	0.0	-1.1
Ulcerative Colitis (UC)	0.8	1.6	5.4	2.3	0.9	-0.1	0.3
Major Depression (MDD)	0.2	0.3	0.7	0.6	0.3	0.8	0.2
Reaction Time	0.5	1.0	2.0	0.2	1.4	-0.3	-1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.3	-1.2	-0.4	1.4	-1.5
Breast Cancer	0.5	1.3	3.8	1.9	0.1	-0.5	1.1
Ovarian Cancer	1.3	1.7	2.8	-0.7	-1.7	-1.0	1.6
Prostate Cancer	1.5	2.2	7.7	-0.9	0.3	-2.8	0.2
Age at First Birth	0.6	0.9	2.1	-1.5	-0.8	0.0	1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.0	-1.4	0.2	-0.9	-0.8
Coronary Artery Disease (CAD)	0.4	0.4	1.3	-0.1	-0.6	0.3	1.1
Crohns Disease (2012)	0.8	1.3	4.5	0.2	-0.7	0.1	-2.1
Mean Putamen Volume	0.6	0.6	1.1	-1.1	-0.9	-0.4	0.7
Fasting Glucose	1.6	2.0	5.1	2.3	-0.0	1.6	-0.1
HbA1C	1.1	1.2	2.0	0.2	1.0	1.4	-1.4
HDL Cholesterol	0.6	1.1	3.2	1.8	0.7	-0.6	-0.5
LDL Cholesterol	0.8	1.2	1.9	-0.7	-1.3	1.4	0.9
Lupus	0.5	0.8	3.0	1.7	0.0	0.2	-0.2
Neuroticism (2016)	0.9	1.4	2.8	-1.7	-0.7	-0.6	1.3
Primary Biliary Cirrhosis	0.3	0.4	1.4	-0.3	-0.5	-1.2	-0.0
Rheumatoid Arthritis	0.9	1.3	4.6	2.2	0.4	0.5	-0.0
Schizophrenia (2014)	0.1	0.2	0.4	-0.0	-0.5	-0.7	0.2
Triglycerides	0.2	0.3	0.5	-0.6	-0.7	0.3	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	-1.0	-1.1	0.4	-0.1
Ulcerative Colitis	0.6	0.9	2.2	1.5	0.5	1.0	-0.5
Blood Eosinophil Count	0.2	1.8	4.2	-0.9	-0.6	-2.0	1.4
Blood Platelet Count	0.9	10.8	22.1	-1.4	4.7	3.9	-1.9
Blood Red Count	5.9	57.5	156.2	2.3	4.8	6.7	-12.5
Blood White Count	0.4	3.2	8.9	-0.3	3.0	1.5	-1.1
Heel T-Score	0.2	1.4	5.5	0.3	0.1	-2.4	-0.4
BMI	0.6	3.3	6.5	0.5	1.2	2.5	-2.2
Height	0.2	3.8	6.4	-2.5	0.9	1.5	-2.4
Waist Hip Ratio (WHR)	2.4	10.9	23.0	2.2	2.9	4.8	-2.7
Systolic Blood Pressure	0.1	0.3	0.7	0.5	0.9	-0.1	0.4
Smoking Status	0.3	0.7	1.3	-1.1	-0.7	1.0	-0.3
Allergy or Eczema	2.0	5.2	7.5	-2.7	-2.5	-2.0	1.8
Cardiovascular Disease	0.5	1.8	4.9	-0.6	0.8	2.2	-1.1
Hypothyroidism (self reported)	0.8	1.7	4.8	1.3	0.4	0.5	-2.2
Respiratory disease	0.6	1.3	2.8	-0.3	-1.7	-0.9	1.2
Type 2 Diabetes (T2D) (2018)	3.1	5.8	10.5	0.8	1.7	3.2	-3.0
Lung FEV1/FVC ratio	0.3	1.7	4.7	1.2	2.2	0.2	-0.7
Lung FVC	0.4	1.9	4.0	-2.0	-1.9	0.1	0.4
Neuroticism	0.6	1.5	3.1	-1.1	-0.9	-0.9	1.8
Chronotype (morning person)	0.7	1.6	6.0	0.4	-0.1	-0.2	2.5
Hair Pigment	0.1	2.2	4.5	-1.9	-2.1	-0.5	0.9
Tanning	0.1	0.8	2.4	1.6	0.7	0.4	0.3
Hand grip strength (left)	0.3	0.8	2.6	-0.3	0.8	-1.6	0.3
Number of treatments/medications taken	1.0	1.8	3.6	-1.9	-0.7	-1.8	0.1
Average weekly spirits intake	0.1	0.1	0.1	-0.3	0.1	0.4	-0.2
Sensitivity / hurt feelings	0.7	1.1	2.3	-0.3	-1.5	0.0	1.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	0.4	-0.9	0.5	0.8
Hearing difficulty/problems: Yes	1.2	1.8	3.6	0.9	-1.9	0.1	1.8
Relative age of first facial hair	1.5	3.0	12.0	-0.1	-0.2	3.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-0.4	-0.9	-1.2	-0.9
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.0	-1.0	-1.5	-1.7	1.4
Ever had hysterectomy (womb removed)	1.9	2.2	4.1	-2.0	-1.9	-0.9	-0.1
Systolic blood pressure, automated reading	0.2	0.6	0.9	0.5	-0.6	-1.0	0.9
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.0	1.3	-0.3	1.3	-1.4
Angina	0.2	0.2	0.8	0.9	0.3	-0.0	-0.3
Medication for hormone replacement therapy	0.4	0.5	1.8	-0.4	-1.3	0.1	-0.1
Vitamin and mineral supplements	1.5	2.0	5.1	-1.6	-2.3	0.5	-0.3
Supplements: Zinc	2.2	2.4	7.8	2.8	1.0	-1.0	0.1
Medication: Co-codamol	0.7	0.8	2.8	-0.5	-1.7	0.0	0.4
Medication: Metformin	0.9	1.3	2.8	0.7	0.9	1.0	-1.7
Diabetes (father)	0.8	0.9	2.4	1.0	-1.6	0.5	-0.0
Diabetes (mother)	0.3	0.3	0.7	-0.1	0.6	-0.4	-0.8
Severe depression (siblings)	0.5	0.6	1.0	1.0	0.8	-0.2	-0.9
Pack years adult smoking proportion	0.8	1.2	3.1	0.5	-1.2	1.8	0.3
Impedance of leg (right)	0.2	0.8	1.3	0.5	-0.9	-1.1	0.8
Leg fat-free mass (left)	1.4	7.6	11.9	-1.2	2.4	3.5	-3.4
Trunk fat percentage	0.8	3.4	11.3	-0.4	0.2	1.4	-3.4
Hand grip strength (right)	0.3	0.7	2.0	0.2	1.4	-0.7	0.5
Townsend deprivation index at recruitment	0.7	1.0	1.5	1.2	0.5	1.2	0.9
Current tobacco smoking	0.9	1.4	2.8	-0.9	-1.7	1.4	0.2
Average weekly fortified wine intake	0.8	1.0	3.5	-0.3	1.9	-0.4	-0.4
Maternal smoking around birth	0.9	1.4	5.1	0.4	0.2	2.3	-0.4
Fed-up feelings	1.7	3.0	6.2	1.7	0.8	2.5	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.3	-0.8	0.1	0.5
Relative age voice broke	0.8	1.3	2.5	-1.0	-1.6	1.2	0.1
Taking other prescription medications	4.1	6.4	11.1	-2.2	-2.5	-3.3	1.8
Age when periods started (menarche)	0.6	1.5	5.7	0.2	-0.3	2.4	-0.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.7	-1.6	-0.6	-1.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	-1.0	-0.1	-0.5	0.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.9	1.3	-0.9	-1.3	2.0
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.2	-0.5	0.7	-0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.2	-0.2	0.2	0.4
High blood pressure	0.1	0.3	0.4	-0.7	0.4	0.7	0.3
Hayfever, allergic rhinitis or eczema	2.4	5.3	8.6	-2.4	-2.9	-1.5	2.1
Multivitamins +/- minerals	0.9	1.1	3.5	0.9	1.9	0.2	-0.0
Stomach or abdominal pain in last month	0.3	0.3	0.6	-0.2	-0.3	0.8	0.7
Supplements: Glucosamine	0.5	0.6	2.5	0.1	1.6	0.3	-0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.3	0.5	0.3	-0.3
Medication: Atenolol	0.3	0.4	0.7	0.8	-0.5	-0.4	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.2	1.1	-1.1	-0.4	-0.5
Sitting height	1.0	7.0	13.6	-3.7	-0.7	2.8	-2.5
Chronic bronchitis/emphysema (father)	1.3	1.5	5.8	0.2	0.3	-2.4	0.5
High blood pressure (mother)	0.5	0.7	1.5	-1.0	0.5	0.5	-1.2
Body mass index (BMI)	0.4	1.9	4.4	-0.3	0.5	1.7	-2.1
Impedance of leg (left)	0.3	1.2	2.2	0.6	-0.9	-1.5	1.2
Leg predicted mass (left)	1.4	7.5	11.5	-1.2	2.4	3.4	-3.4
Trunk fat mass	1.1	4.6	13.0	-0.7	1.0	2.0	-3.6
Waist circumference	1.4	5.0	10.6	-0.4	1.5	2.7	-3.2
Number of incorrect matches in round	0.8	1.3	3.1	1.8	0.7	-0.5	1.1
Past tobacco smoking	1.5	2.7	4.5	1.7	1.4	2.1	-1.3
Alcohol usually taken with meals	1.9	3.1	7.1	0.8	0.7	-2.7	2.0
Nervous feelings	1.3	2.4	3.9	-0.3	-2.0	-1.4	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.0	1.4	-1.1	1.1	0.4
Hearing difficulty/problems with background noise	1.0	1.6	4.0	0.3	-1.2	2.0	1.1
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	0.3	-0.9	-0.4	-0.6
Had menopause	2.3	2.8	5.5	-0.5	-1.5	-2.3	1.8
Had other major operations	0.7	0.8	1.7	-1.0	-0.7	-0.1	1.3
Forced vital capacity (FVC)	0.4	1.6	3.0	-1.3	0.8	1.7	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	-0.9	-0.1	-0.8	0.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	4.3	0.6	2.1	-0.6	-0.9
Qualifications: None of the above	0.2	0.5	1.2	1.1	-0.1	0.8	0.0
Financial difficulties in last 2 years	1.2	1.7	5.4	0.3	0.1	2.3	-1.0
Mouth/teeth dental problems	0.6	1.0	2.2	-1.5	-1.0	-0.5	0.7
Heart attack	0.6	0.8	1.4	1.2	0.7	0.9	-0.7
Allergy	1.5	3.4	6.5	1.3	2.6	1.1	-2.1
Pain all over the body in last month	0.5	0.5	1.2	1.1	-0.4	0.7	-0.6
Diabetes (self-reported)	1.3	2.0	4.8	1.0	0.7	1.4	-2.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.5	-1.0	-0.2	-0.0
Medication: Ramipril	1.0	1.3	4.1	-0.8	0.5	0.2	-2.0
Medication: Simvastatin	1.3	1.9	4.5	-0.1	-1.4	1.1	-2.1
Fluid intelligence score	0.2	0.5	1.0	-1.0	0.8	0.5	0.4
Illnesses of siblings	1.3	1.9	4.7	0.7	1.0	1.2	-2.2
Neuroticism score	0.5	1.0	2.0	-0.5	-1.4	-0.1	1.4
Weight	1.0	5.0	9.8	-1.1	1.5	2.6	-3.1
Impedance of arm (right)	0.2	1.1	2.7	-0.7	-1.6	-0.5	-1.0
Arm fat percentage (right)	0.8	3.3	11.1	-0.7	-0.0	1.3	-3.3
Trunk fat-free mass	0.8	4.4	6.6	-1.3	2.4	2.6	-1.9
Hip circumference	0.8	3.5	8.4	-2.1	0.1	1.1	-2.9
Time employed in main current job	0.5	0.6	0.8	0.2	-0.9	-0.8	-0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3
Father’s age at death	1.1	1.5	3.1	0.4	-0.4	-1.8	1.6
Worrier / anxious feelings	0.8	1.4	3.5	-1.0	-1.9	-0.4	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.2	1.0	-0.6	1.1	-0.5
Falls in the last year	1.2	1.6	3.6	1.9	1.5	0.1	-0.8
Hair/balding pattern: Pattern 3	1.2	1.8	4.9	1.0	0.8	-0.9	2.2
Number of live births	1.1	1.6	3.4	1.8	-0.7	1.2	1.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.3	-0.5	2.1	1.9	-1.5
Pulse rate	0.6	1.0	2.1	-1.5	1.0	-0.3	-0.8
Happiness	1.6	1.9	6.0	1.2	2.5	0.1	0.1
Noisy workplace	1.1	1.4	3.6	0.8	-0.1	1.9	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	1.2	0.2	0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	-1.4	-0.2	0.6	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.1	-0.6	-0.9	0.5
Asthma	0.5	1.0	2.6	-0.3	-1.6	-0.7	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	-1.1	-0.0	0.0	1.0
Medication: Cholesterol lowering	0.4	0.6	1.3	-0.3	-1.2	0.6	-0.7
Depression (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.1
Medication: Lansoprazole	1.7	2.0	4.8	-1.5	0.4	-0.7	-2.2
Prospective memory result	1.6	2.0	5.2	1.4	-2.3	-0.4	0.8
Lung cancer (father)	0.3	0.4	0.5	-0.5	0.7	-0.5	-0.7
Illnesses of mother	1.1	1.3	5.0	-0.1	-0.3	-0.4	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.0	-1.7	1.1	1.7	-1.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.9	-0.3	-0.2	-0.6
Impedance of arm (left)	0.1	0.7	1.3	-0.1	-1.1	-0.4	-1.1
Arm fat mass (right)	1.1	4.5	12.3	-0.9	0.9	2.1	-3.5
Trunk predicted mass	0.8	4.5	6.5	-1.4	2.4	2.6	-1.9
Standing height	0.6	5.8	8.2	-2.1	2.1	2.5	-2.9
Length of working week for main job	0.9	1.0	2.0	0.4	-0.3	1.4	1.4
Exposure to tobacco smoke at home	1.7	1.9	6.5	-0.9	-2.5	0.6	0.2
Breastfed as a baby	0.7	0.9	2.2	-0.2	0.9	-1.5	0.7
Tense / ‘highly strung’	0.4	0.7	1.7	1.3	-0.9	0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	3.4	-0.4	-0.5	-1.8	1.8
Hair/balding pattern: Pattern 4	1.0	2.4	6.9	-2.6	1.4	-0.5	-0.6
Birth weight of first child	0.9	1.6	3.9	-0.3	-1.5	-0.1	2.0
Peak expiratory flow (PEF)	1.0	2.3	4.4	0.3	2.1	1.5	-1.5
Pulse wave reflection index	0.6	0.8	2.2	-0.6	-1.5	0.7	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.1	0.5	-0.4	0.0
Loud music exposure frequency	0.4	0.5	1.6	-0.1	1.3	-0.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	1.7	1.3	1.1	1.2	-1.0
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	5.4	1.3	2.3	1.4	-1.8
Blood clot in the leg (DVT)	0.8	1.0	2.0	0.7	1.4	-0.6	1.0
Medication: Paracetamol	0.3	0.5	1.1	0.3	0.1	0.9	-1.0
Headache pain in last month	0.4	0.6	2.0	-0.3	0.1	-1.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.6	0.7	1.3	-0.1	0.3
Glaucoma (self-reported)	0.2	0.2	0.7	-0.1	-0.1	-0.1	0.8
Gout (self-reported)	0.3	0.5	0.6	-0.6	0.6	0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.1	1.0	-1.0	-0.6	-0.8
Medication: Amlodipine	0.7	1.0	2.5	-1.6	1.1	-0.4	-0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.1	0.6	-1.4	0.5	-0.4
Birth weight	0.2	0.4	1.1	1.1	0.5	-0.4	0.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.7	0.6	-0.6	1.6	-1.0
High blood pressure (siblings)	0.4	0.6	1.6	-0.8	0.1	-0.2	1.2
Forced vital capacity (FVC), Best measure	0.7	2.4	5.8	-2.4	-0.1	1.6	-1.0
Body fat percentage	0.7	2.9	9.6	-0.4	0.0	1.3	-3.1
Leg fat percentage (right)	0.2	0.8	3.2	0.1	-0.1	0.4	-1.8
Arm fat-free mass (right)	0.8	3.9	6.2	-0.9	2.4	2.5	-1.7
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-1.0	-1.0	0.3	-0.3
Comparative body size at age 10	0.2	0.5	1.1	-1.0	0.6	-0.2	0.6
Number of full brothers	0.2	0.3	0.7	-0.9	-0.6	-0.0	0.3
Worry too long after embarrassment	0.3	0.4	0.9	-0.1	-0.7	-0.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.9	0.1	-0.5	-0.5	1.7
Wheeze or whistling in the chest in last year	0.1	0.3	0.5	0.4	-0.7	0.6	-0.2
Number of children fathered	0.2	0.2	0.6	0.7	0.2	0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.6	-1.6	-0.9	0.6	0.1
Age at first live birth	0.2	0.4	0.7	-0.0	0.7	-0.8	0.5
Pulse wave peak to peak time	0.3	0.4	0.9	0.9	0.6	0.5	0.3
Health satisfaction	0.9	1.1	3.2	-1.8	-0.8	-0.7	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.6	-0.0	0.2	0.0
Qualifications: College or University degree	0.5	1.5	3.4	0.2	1.8	0.1	-1.5
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.6	0.0	0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.5	0.0	-1.6	0.8	0.1
Emphysema/chronic bronchitis	0.4	0.4	0.7	-0.3	-0.7	0.7	0.8
Medication for pain relief, constipation, heartburn	0.4	0.8	1.5	1.1	1.2	0.5	0.3
Neck or shoulder pain in last month	1.9	2.6	4.1	2.0	-0.6	-2.0	1.5
Medication: Blood pressure	0.1	0.1	0.3	-0.5	0.3	-0.4	-0.2
Angina (self-reported)	0.3	0.5	1.7	1.3	0.3	0.1	-0.2
Migraine (self-reported)	1.5	1.8	3.7	-1.4	1.9	0.0	-1.3
Medication: Ibuprofen	0.8	1.0	2.1	-1.5	-0.5	-0.1	1.2
Medication: Allopurinol	1.2	1.6	2.2	-0.6	1.4	1.5	-1.4
Medication: Omeprazole	1.6	1.9	3.5	-1.7	-0.9	-1.9	0.5
Medication: Seretide 50 evohaler	1.0	1.2	1.7	-1.3	-1.3	-1.2	0.1
Mean time to correctly identify matches	0.5	0.9	1.9	0.1	0.4	-1.4	-1.2
Heart disease (mother)	0.6	0.7	1.2	0.7	-1.1	1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.9	-0.2	-1.2	-1.4	0.1
Whole body fat mass	1.0	4.1	10.8	-0.7	0.8	2.1	-3.3
Leg fat mass (right)	0.7	2.7	6.8	-0.4	0.9	1.8	-2.6
Arm predicted mass (right)	0.9	4.4	7.3	-0.7	2.7	2.4	-2.0
Pulse rate, automated reading	0.4	1.3	2.1	-0.6	1.2	-1.5	-1.2
Alcohol intake frequency.	0.2	0.4	0.8	0.9	-0.5	0.5	-0.5
Comparative height size at age 10	0.5	2.8	5.3	-1.4	2.0	0.3	-2.3
Number of full sisters	1.1	1.3	4.0	-0.5	-2.0	-0.1	1.0
Suffer from ‘nerves’	0.3	0.5	1.1	-0.7	-0.7	-0.1	1.1
Overall health rating	1.5	3.3	5.6	1.4	1.0	2.1	-2.4
Chest pain or discomfort	0.0	0.1	0.1	0.0	0.3	-0.1	0.4
Had major operations	1.2	1.4	3.2	-0.9	-0.3	-1.8	1.2
Age at last live birth	0.3	0.5	0.9	0.3	0.7	-0.9	0.8
Family relationship satisfaction	0.5	0.6	2.0	-0.3	1.4	0.0	0.5
Leg pain on walking	2.4	3.0	9.4	-0.1	0.5	3.1	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	-0.4	0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	0.5	-0.4	-0.3	1.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	6.0	1.4	2.5	-0.0	-1.1
Medication: Aspirin	0.2	0.3	0.3	0.6	-0.6	-0.5	-0.6
Supplements: Vitamin C	1.2	1.4	2.3	1.5	1.5	-0.5	0.9
Knee pain experienced in last month	1.8	2.8	6.9	2.6	0.8	1.9	0.1
Hypertension (Self-reported)	0.1	0.3	1.0	-1.0	0.3	-0.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.6	-1.6	0.1	-1.3	0.7
Illnesses of father: Heart disease	2.1	2.9	5.2	0.9	1.6	2.3	-1.7
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.4	-0.1	-1.2	0.3
Smoking status: Previous	0.9	1.3	3.8	-0.5	-0.6	-1.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.7	-1.6	-0.1	2.2	-1.6
Whole body fat-free mass	1.0	5.5	8.8	-1.3	2.4	3.0	-2.4
Leg fat-free mass (right)	1.3	6.7	10.4	-1.2	2.4	3.2	-3.0
Arm fat percentage (left)	0.9	3.6	11.9	-0.5	0.3	1.5	-3.5
Average weekly red wine intake	0.2	0.3	0.6	-0.3	0.8	-0.6	0.5
Handedness (chirality/laterality): Left-handed	1.2	1.5	5.2	-0.7	-2.3	-0.4	0.4
Mood swings	0.5	0.8	2.5	0.9	0.0	0.2	1.6
Loneliness, isolation	0.8	1.1	1.9	-0.6	1.2	1.4	-0.7
Long-standing illness, disability or infirmity	0.8	1.2	2.9	1.1	0.6	-1.7	-0.4
Ever had bowel cancer screening	2.7	3.2	6.4	-0.2	0.6	-2.5	2.5
Diabetes diagnosed by doctor	1.3	2.2	3.9	1.1	0.9	1.7	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	5.7	-0.5	-0.6	-1.6	2.4
Friendships satisfaction	1.7	2.1	4.1	-0.5	2.0	-0.1	2.0
Qualifications: nursing, teaching	0.2	0.3	0.7	0.5	0.4	0.4	-0.8
Commuting to job workplace: Walk	2.1	2.2	4.8	0.2	1.4	1.5	-2.2
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.7	-0.6	-0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	1.3	-0.5	-0.1	-1.0
Medication for cholesterol	0.4	0.6	1.4	-0.1	0.3	-1.0	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	5.6	0.8	0.8	2.4	-0.9
Back pain experienced in last month	1.3	1.8	6.8	-0.6	0.4	2.6	-0.0
Mineral and other dietary supplements	1.2	1.6	3.5	-1.2	-1.9	1.3	-0.1
Breast cancer (self-reported)	0.8	1.0	2.7	-0.4	1.7	0.9	-0.5
Asthma (self-reported)	0.5	0.9	2.5	-0.3	-1.6	-0.6	0.9
Osteoporosis (self-reported)	0.6	0.7	1.9	-1.4	-0.6	-0.6	0.2
Osteoarthritis (self-reported)	0.6	0.7	1.8	1.3	-0.4	0.8	-0.5
Medication: Aspirin	0.3	0.4	0.8	0.2	-0.6	-0.7	-0.9
Medication: Gliclazide	6.3	7.2	20.5	0.7	1.4	2.4	-4.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.1	-0.2	1.0	-1.0
Smoking status: Current	0.9	1.4	3.0	-0.7	-1.7	1.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.5	-1.1	1.6	-0.2	-1.2
Whole body water mass	1.0	5.6	8.9	-1.3	2.5	3.0	-2.4
Leg predicted mass (right)	1.3	6.8	10.3	-1.2	2.4	3.2	-3.1
Arm fat mass (left)	1.2	5.0	13.3	-0.4	1.3	2.2	-3.6
Number of self-reported non-cancer illnesses	0.8	1.3	4.3	-0.3	-0.3	-2.1	0.9
Average weekly champagne plus white wine intake	0.8	1.1	2.7	-0.5	-0.5	-1.1	1.7
Miserableness	0.4	0.6	2.1	-0.3	-0.5	-0.2	1.4
Guilty feelings	0.5	0.8	2.1	0.9	-1.5	0.1	-0.2
Wears glasses or contact lenses	2.4	2.7	5.9	-0.7	-2.0	-2.4	0.6
Ever taken oral contraceptive pill	0.4	0.5	1.1	-1.1	0.7	0.0	-0.5
Hearing aid user	1.3	1.5	3.1	0.2	-1.8	0.4	1.6
Mother’s age at death	2.9	3.6	8.9	-0.7	-0.3	-3.0	2.2
Financial situation satisfaction	3.5	4.3	8.1	1.3	1.7	2.1	-2.8
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.1	1.8	0.9	0.7	-0.2
Commuting to job workplace: Public transport	4.9	5.9	9.5	3.1	2.5	1.9	-2.1
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	-0.6	-0.5	-0.1	1.0
Medication: Blood pressure	1.1	2.1	4.2	-0.1	2.0	1.4	-1.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.3	-2.1	-0.5	-1.4	1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.0	1.4	1.2	-0.5	0.4
High cholesterol (Self-reported)	1.3	2.4	4.9	1.1	-1.0	2.2	-1.5
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.3	0.1	-0.8	-0.4
Medication: Paracetamol	0.1	0.2	0.5	0.2	0.1	0.7	-0.3
Medication: Lisinopril	0.6	0.7	2.0	-0.3	-0.4	-0.8	-1.4
Medication: Atorvastatin	0.3	0.3	0.9	0.6	-1.0	0.1	-0.1
Illnesses of father: High blood pressure	1.6	2.0	2.7	1.5	1.6	1.6	0.8
Alcohol drinker status: Never	0.3	0.3	0.7	-0.3	-0.1	0.7	-0.9
Ever smoked	1.8	3.1	5.4	-1.8	-1.2	-2.3	1.6
Basal metabolic rate	1.1	6.0	9.5	-1.3	2.4	3.1	-2.7
Leg fat percentage (left)	0.2	0.8	2.9	0.2	0.1	0.3	-1.7
Arm fat-free mass (left)	0.8	4.1	5.7	-1.2	2.3	2.4	-2.0
Number of operations (self-reported)	1.8	2.7	4.5	-1.6	-1.1	-2.1	1.6
Average weekly beer plus cider intake	3.9	5.6	11.8	0.7	0.8	3.4	-3.1
Irritability	1.5	2.5	8.3	0.2	0.4	2.9	-1.3
Risk taking	1.5	2.2	4.3	1.7	2.1	-0.2	1.1
Ever had prostate specific antigen (PSA) test	1.6	1.8	4.4	-0.2	-1.0	-2.1	1.4
Fractured/broken bones in last 5 years	0.9	1.1	1.8	-1.0	1.3	1.4	-0.1
Age started oral contraceptive pill	0.6	0.8	1.8	-1.3	-0.1	-1.1	0.2
Diastolic blood pressure, automated reading	0.2	0.5	1.1	-0.7	0.6	0.3	-1.1
Ever depressed for a whole week	1.6	1.9	3.5	0.9	1.9	-1.3	1.3
Unable to work because of sickness or disability	0.1	0.1	0.4	0.1	0.0	0.6	-0.3
Commuting to job workplace: Cycle	0.6	0.7	0.8	0.8	0.8	0.9	0.8
Myopia	0.8	1.1	4.0	0.3	-0.1	-0.6	2.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	0.7	-0.4	-0.0	-0.6
Cholesterol lowering medication	1.0	1.5	3.5	-0.6	-0.8	1.1	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.4	-1.4	-1.0	-2.1	0.7
Pain experienced in last month	0.2	0.4	0.5	-0.5	0.6	0.5	-0.7
Supplements: Calcium	0.6	0.6	1.4	-0.7	-0.7	-1.2	0.4
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	-0.6	-1.4	-1.6	-0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.5	1.2	0.9	1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.6	1.3	-0.4	1.0
Heart disease (siblings)	0.8	1.0	2.3	-0.2	-1.5	0.6	1.1
Alcohol drinker status: Previous	0.4	0.5	1.2	0.6	0.1	0.6	-1.1
Pack years of smoking	1.0	1.5	3.5	0.7	-1.4	1.9	-0.0
Impedance of whole body	0.1	0.5	1.1	0.3	-0.9	-1.0	-0.1
Leg fat mass (left)	0.7	2.7	6.6	-0.3	1.1	1.8	-2.6
Arm predicted mass (left)	0.8	4.2	5.8	-1.2	2.4	2.4	-1.9