Hub : Genes

FGF17

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.3470 0.105 0.00370 0.001 NA 0.047 NA 0.074 3.0e-01 NA 2.4e-02 NA 6.0e-03
2 GTEx Ovary 0.3840 0.134 0.00390 -0.002 NA 0.017 NA 0.029 3.6e-01 NA 1.2e-01 NA 6.7e-02
3 GTEx Skin Not Sun Exposed Suprapubic 0.1870 0.077 0.00760 -0.005 NA -0.003 NA -0.004 8.5e-01 NA 5.5e-01 NA 6.9e-01
4 GTEx Thyroid 0.0950 0.040 0.00530 0.108 NA 0.095 NA 0.099 1.3e-08 NA 9.7e-08 NA 5.4e-08
5 TCGA Lung Adenocarcinoma 0.0812 0.031 0.00016 0.032 0.046 0.044 NA 0.043 1.1e-04 4.4e-06 6.3e-06 NA 9.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 1.0 2.5 0.8 0.2 1.3 -0.3 -1.6
Bipolar Disorder or Schizophrenia 0.1 0.2 0.7 0.3 0.1 0.5 -0.1 -0.8
Depressed Affect (Nagel 2018) 2.1 4.4 7.2 -2.7 -2.6 2.2 -1.4 1.2
Depression (Nagel 2018) 2.2 3.4 8.2 -2.4 -2.9 1.0 -1.3 -0.1
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.6 0.2 0.5 -0.8 -0.7 -0.3
Neuroticism (Nagel 2018) 1.4 3.3 6.5 -2.4 -2.5 1.2 -1.6 0.4
Schizophrenia (2018) 0.0 0.1 0.3 -0.3 -0.1 -0.6 0.0 0.2
Schizophrenia vs Biploar Disorder 1.0 1.3 5.1 -0.1 -0.5 0.4 1.0 2.2
Worry (Nagel 2018) 1.4 3.0 6.1 -2.5 -2.4 0.5 -1.7 -0.5
Alzheimer’s Disease (in mother) 0.5 0.5 1.0 0.6 -0.5 -1.0 1.0 -0.2
Alzheimer’s Disease (in father) 2.1 2.3 6.1 -1.4 -0.2 0.3 -2.5 -1.8
Alzheimer’s Disease (including proxy) 0.4 0.5 1.8 0.7 -0.6 0.2 -0.1 -1.3
Crohns Disease (2017) 1.1 2.3 7.3 1.7 0.9 -0.1 2.7 0.8
Irritable Bowel Disease (IBD) 1.3 3.1 7.0 1.8 2.2 0.8 2.6 0.3
Ulcerative Colitis (UC) 1.0 1.9 4.5 1.1 2.1 1.2 1.6 -0.4
Major Depression (MDD) 0.6 0.7 1.4 0.7 -1.1 1.2 0.8 0.0
Reaction Time 0.5 1.0 2.1 -0.0 -1.1 1.2 0.2 1.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.8 -0.5 0.5 -0.6 -1.7 1.2
Breast Cancer 0.3 0.6 1.2 0.6 0.6 0.6 1.1 -0.9
Ovarian Cancer 1.4 1.8 5.1 -1.3 -0.8 2.2 -0.7 -1.0
Prostate Cancer 0.8 1.1 2.4 -1.5 0.3 -0.0 -1.4 -1.0
Age at First Birth 0.5 0.7 1.8 -0.3 0.3 1.3 -0.8 -0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 0.0 1.2 -1.3 -0.5 -0.1
Coronary Artery Disease (CAD) 0.8 1.0 3.4 1.8 0.8 0.7 0.4 0.0
Crohns Disease (2012) 0.1 0.2 0.4 -0.3 -0.3 0.0 0.5 0.7
Mean Putamen Volume 0.5 0.6 2.4 -0.4 -0.1 0.3 -1.6 -0.6
Fasting Glucose 1.5 1.9 3.0 1.7 1.5 0.1 1.7 1.2
HbA1C 0.6 0.7 2.2 1.1 0.1 -0.2 0.3 1.5
HDL Cholesterol 0.6 0.9 2.0 0.6 1.4 -0.2 1.1 -1.0
LDL Cholesterol 0.4 0.7 3.0 0.4 -0.1 -0.6 -1.7 -0.2
Lupus 0.1 0.2 0.5 0.0 -0.7 -0.3 0.5 -0.1
Neuroticism (2016) 1.8 2.6 5.7 -2.4 -1.8 1.0 -1.8 -0.0
Primary Biliary Cirrhosis 0.1 0.2 0.4 0.3 -0.4 0.4 -0.1 -0.6
Rheumatoid Arthritis 1.5 2.0 5.9 2.4 0.2 1.0 1.7 -0.1
Schizophrenia (2014) 0.2 0.4 1.0 -1.0 -0.9 0.4 -0.2 -0.4
Triglycerides 0.4 0.6 2.5 0.5 -1.6 -0.5 -0.3 0.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.3 -1.0 -1.1 -0.3 -1.1 0.0
Ulcerative Colitis 0.9 1.3 2.5 1.4 1.6 0.7 1.3 0.1
Blood Eosinophil Count 0.5 3.7 6.1 -1.4 -1.9 2.5 -1.7 -1.9
Blood Platelet Count 0.7 8.7 31.6 -1.6 1.4 -1.7 -2.1 5.6
Blood Red Count 3.4 33.1 78.3 3.5 7.8 1.0 3.5 8.8
Blood White Count 0.6 4.3 8.0 -2.8 -0.7 0.7 -2.2 2.8
Heel T-Score 0.2 1.2 3.3 1.3 0.1 -1.8 -0.1 -1.0
BMI 0.4 2.1 9.9 -0.2 0.0 0.4 0.5 3.1
Height 0.4 6.8 10.4 -3.0 -1.0 1.8 -3.2 3.2
Waist Hip Ratio (WHR) 1.2 5.4 18.9 0.9 -1.9 0.5 1.9 4.3
Systolic Blood Pressure 0.1 0.4 0.7 -0.8 0.8 0.5 -0.3 0.8
Smoking Status 2.7 6.4 9.8 -2.9 -3.1 1.7 -2.6 1.8
Allergy or Eczema 1.1 2.8 6.3 -0.7 0.9 -1.5 -2.1 -2.5
Cardiovascular Disease 0.7 2.3 8.8 -0.8 1.4 -0.1 -0.5 3.0
Hypothyroidism (self reported) 0.5 1.3 2.1 1.5 1.0 -1.1 0.8 1.1
Respiratory disease 0.6 1.2 3.0 0.3 -1.5 0.8 -0.6 -1.7
Type 2 Diabetes (T2D) (2018) 2.0 3.7 15.1 -1.0 -0.7 0.7 1.2 3.9
Lung FEV1/FVC ratio 0.4 1.8 3.8 -2.0 -1.5 0.9 0.5 1.5
Lung FVC 0.6 2.9 8.5 -0.9 0.5 -2.2 -2.9 -0.3
Neuroticism 1.5 3.7 7.7 -2.8 -2.6 1.2 -1.6 -0.0
Chronotype (morning person) 0.4 0.9 2.6 0.9 -0.2 -1.6 0.6 -1.0
Hair Pigment 0.2 4.6 11.8 -3.4 1.9 -0.3 -2.7 -0.3
Tanning 0.1 1.2 3.2 1.8 -0.6 -0.2 1.5 0.4
Hand grip strength (left) 0.3 0.8 2.1 -0.6 -0.2 1.1 -1.4 -0.6
Number of treatments/medications taken 0.9 1.6 4.5 -1.4 0.2 -1.0 -2.1 -0.5
Average weekly spirits intake 0.2 0.2 0.4 -0.1 -0.5 0.6 0.1 0.7
Sensitivity / hurt feelings 0.3 0.5 1.1 0.6 -1.0 0.5 -0.7 -0.6
Frequency of depressed mood in last 2 weeks 0.8 1.2 3.6 -0.8 -1.9 1.2 -0.4 0.3
Hearing difficulty/problems: Yes 1.1 1.7 5.3 -0.6 -1.5 2.3 -0.2 -0.6
Relative age of first facial hair 0.7 1.4 6.7 -0.4 -0.0 0.4 -0.0 2.6
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.1 -1.0 0.5 -0.2 -1.0 -0.4
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.7 -0.6 -0.1 0.6 -0.8 -1.3
Ever had hysterectomy (womb removed) 1.3 1.5 3.6 -1.2 1.4 -0.5 -1.9 -0.1
Systolic blood pressure, automated reading 0.2 0.6 1.2 -0.8 1.1 0.8 -0.3 -0.7
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 2.9 -0.4 -0.7 1.7 1.4 1.3
Angina 1.0 1.3 3.5 1.5 -1.9 0.8 0.3 0.1
Medication for hormone replacement therapy 0.3 0.3 0.8 0.1 -0.6 0.9 -0.4 -0.3
Vitamin and mineral supplements 0.5 0.6 2.5 -0.7 -0.4 -0.1 -1.6 -0.3
Supplements: Zinc 2.3 2.5 6.2 2.2 -0.7 0.1 2.5 -1.0
Medication: Co-codamol 0.1 0.1 0.2 0.1 -0.3 0.4 0.2 0.5
Medication: Metformin 0.6 0.8 1.3 -0.7 -0.4 0.9 1.1 1.1
Diabetes (father) 0.5 0.6 1.6 -0.3 -1.3 0.8 0.9 0.2
Diabetes (mother) 1.2 1.5 3.0 -1.1 -0.4 -1.7 -1.3 1.3
Severe depression (siblings) 0.6 0.7 1.4 0.9 0.5 0.7 1.2 0.7
Pack years adult smoking proportion 0.6 0.8 2.1 -0.5 0.2 1.4 0.1 1.5
Impedance of leg (right) 0.0 0.2 0.6 -0.4 0.0 -0.1 -0.2 -0.8
Leg fat-free mass (left) 0.9 4.9 19.3 -1.7 -0.3 1.1 -0.9 4.4
Trunk fat percentage 0.9 3.5 12.9 -1.8 1.0 0.5 0.3 3.6
Hand grip strength (right) 0.5 1.4 3.4 -0.5 -0.5 1.7 -1.8 -0.2
Townsend deprivation index at recruitment 0.4 0.6 1.7 -0.6 -0.4 1.3 0.4 0.6
Current tobacco smoking 0.7 1.1 2.0 -0.8 -1.2 0.9 -1.4 0.7
Average weekly fortified wine intake 1.8 2.1 9.1 0.6 0.9 -3.0 -0.2 -0.2
Maternal smoking around birth 1.3 1.9 6.2 -0.2 1.3 -1.2 0.3 2.5
Fed-up feelings 2.2 4.1 9.3 0.4 -0.4 3.1 1.6 2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.6 6.6 -1.2 -2.6 2.2 -0.4 -0.0
Relative age voice broke 0.4 0.6 2.1 -0.4 -1.5 -0.5 -0.7 0.2
Taking other prescription medications 2.6 3.9 7.9 -1.4 -0.7 -1.7 -2.8 -2.6
Age when periods started (menarche) 0.5 1.3 2.2 -0.5 1.4 1.4 0.0 1.5
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 4.5 -1.6 0.2 0.2 -2.1 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.8 -0.2 -0.6 -1.4 -0.5 -0.9
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.1 0.2 -0.5 1.0 1.2 -1.5
Qualifications: CSEs or equivalent 0.7 1.0 2.0 0.3 -1.4 -1.4 0.0 0.9
Serious illness, injury or assault to yourself 0.4 0.5 2.0 -0.3 -0.3 -0.6 -0.0 1.4
High blood pressure 0.3 0.9 2.7 -0.9 0.4 0.4 -0.6 1.6
Hayfever, allergic rhinitis or eczema 1.0 2.2 5.3 -1.1 0.5 -0.4 -2.3 -2.0
Multivitamins +/- minerals 0.4 0.5 1.6 -0.1 -1.3 0.6 0.5 0.4
Stomach or abdominal pain in last month 1.2 1.5 3.2 -0.6 -1.1 1.5 -0.7 1.8
Supplements: Glucosamine 0.3 0.3 1.1 0.1 -0.2 -1.1 -0.7 0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.3 -0.4 0.5 0.2 0.7
Medication: Atenolol 1.8 2.3 5.9 1.5 -1.4 2.4 -0.0 -1.2
Medication: Levothyroxine sodium 0.8 1.3 3.7 1.2 0.5 -1.9 0.6 -0.9
Sitting height 1.5 10.9 22.1 -4.2 -0.5 1.5 -4.7 3.4
Chronic bronchitis/emphysema (father) 0.9 1.1 3.7 -0.0 -0.1 1.9 -1.0 -0.9
High blood pressure (mother) 0.8 1.1 2.3 -1.4 0.3 -1.5 -1.0 0.6
Body mass index (BMI) 0.5 2.1 8.1 -0.9 0.5 1.0 0.1 2.8
Impedance of leg (left) 0.1 0.3 1.4 -0.3 -0.1 -0.0 -0.3 -1.2
Leg predicted mass (left) 0.9 4.8 18.8 -1.7 -0.2 1.1 -0.9 4.3
Trunk fat mass 1.0 4.4 17.1 -2.0 0.6 0.8 -0.1 4.1
Waist circumference 1.0 3.8 17.5 -1.2 -0.1 0.3 -0.2 4.2
Number of incorrect matches in round 0.5 0.9 1.8 0.7 0.4 1.1 1.3 -1.0
Past tobacco smoking 3.1 5.8 11.4 3.4 2.9 -0.8 2.9 0.8
Alcohol usually taken with meals 1.7 2.7 8.3 1.4 1.5 0.5 0.7 -2.9
Nervous feelings 0.8 1.4 2.7 -0.9 -1.6 -0.8 -0.8 -1.5
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 7.3 -0.6 -1.2 2.7 0.0 -0.0
Hearing difficulty/problems with background noise 0.6 1.0 3.5 -0.0 -1.9 0.9 -0.1 0.9
Hair/balding pattern: Pattern 2 0.8 1.0 1.9 -0.5 1.3 1.4 0.8 0.7
Had menopause 1.0 1.3 4.9 -0.6 0.3 0.8 -0.6 -2.2
Had other major operations 1.2 1.5 4.4 -1.7 0.1 0.2 -2.1 -0.3
Forced vital capacity (FVC) 0.6 2.4 5.7 -1.6 0.0 -0.3 -2.4 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 -0.5 -0.7 -0.1 -0.7 -0.8
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.6 0.5 1.1 0.6 0.5 1.6
Qualifications: None of the above 0.1 0.2 0.5 0.5 -0.4 -0.5 0.7 0.4
Financial difficulties in last 2 years 1.9 2.5 7.6 -1.0 0.6 1.7 0.9 2.8
Mouth/teeth dental problems 0.5 0.8 2.8 0.1 0.1 -1.7 -0.6 -0.8
Heart attack 1.2 1.6 3.1 1.0 -1.6 1.8 -0.1 1.1
Allergy 0.5 1.1 4.3 0.2 -0.5 0.3 1.0 2.1
Pain all over the body in last month 1.5 1.6 2.4 1.2 -1.3 1.5 1.5 -0.4
Diabetes (self-reported) 1.0 1.5 3.7 -0.8 -0.2 1.5 1.0 1.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.8 0.7 0.9 -0.1 0.1 0.1
Medication: Ramipril 0.5 0.6 1.5 0.2 1.0 0.8 -0.2 1.2
Medication: Simvastatin 0.4 0.5 1.0 0.6 1.0 -0.6 -0.2 1.0
Fluid intelligence score 0.1 0.3 0.9 0.1 0.5 -0.3 -1.0 -0.2
Illnesses of siblings 0.7 1.0 2.1 0.7 1.4 1.0 0.8 0.9
Neuroticism score 1.1 2.2 4.1 -1.6 -2.0 1.7 -1.2 -0.2
Weight 1.0 4.8 17.8 -1.9 -0.1 1.3 -1.0 4.2
Impedance of arm (right) 0.3 1.6 7.1 -0.4 0.4 -2.7 0.6 0.2
Arm fat percentage (right) 0.7 2.7 10.8 -1.1 0.9 -0.3 0.6 3.3
Trunk fat-free mass 0.6 3.6 10.5 -1.3 -1.2 1.5 -1.4 3.2
Hip circumference 0.9 4.0 9.1 -2.5 0.8 0.3 -2.0 3.0
Time employed in main current job 0.5 0.6 1.5 0.7 1.2 -0.3 0.8 -0.6
Alcohol intake versus 10 years previously 0.2 0.3 1.1 0.2 -0.5 -1.0 0.2 0.1
Father’s age at death 1.2 1.6 5.3 -0.6 1.2 0.5 -0.8 -2.3
Worrier / anxious feelings 0.6 1.1 2.0 -1.2 -1.2 -0.2 -1.4 -0.9
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 11.1 -1.1 -2.2 3.3 -0.2 1.0
Falls in the last year 1.0 1.3 2.7 1.3 -0.7 0.3 1.6 1.3
Hair/balding pattern: Pattern 3 1.3 1.9 5.5 0.8 -2.3 -1.1 -0.5 -1.3
Number of live births 0.5 0.7 1.7 1.3 -0.1 0.1 1.2 -0.4
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 5.8 -1.7 -0.2 -0.3 -1.8 2.4
Pulse rate 0.7 1.1 3.4 -1.8 -0.9 -0.1 0.0 1.2
Happiness 0.7 0.9 1.7 1.3 -0.3 1.2 1.0 0.5
Noisy workplace 1.5 1.8 3.6 0.8 0.2 1.9 1.2 1.8
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.8 1.9 0.8 -1.3 1.7 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.6 -1.3 -0.2 -0.3 -0.8 1.2
Mouth/teeth dental problems: Dentures 0.6 1.1 4.9 -0.2 -0.2 2.2 -0.3 -0.7
Asthma 0.3 0.6 1.0 0.1 -1.0 0.8 -0.6 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 5.8 -1.3 -2.4 -1.8 -0.9 -0.2
Medication: Cholesterol lowering 0.3 0.5 1.4 0.1 0.8 -1.2 -0.5 0.2
Depression (self-reported) 0.3 0.3 0.9 -0.0 -1.0 -0.4 -0.2 0.8
Medication: Lansoprazole 0.9 1.1 3.0 -0.6 0.4 -1.7 -1.4 0.2
Prospective memory result 0.4 0.5 0.7 -0.4 -0.7 0.9 0.8 -0.4
Lung cancer (father) 0.4 0.5 1.3 -1.0 0.3 -0.5 -1.1 0.3
Illnesses of mother 0.4 0.5 1.0 -0.2 -0.5 0.9 -0.4 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 8.3 -2.9 -0.3 -0.9 -2.7 2.3
Pulse wave Arterial Stiffness index 0.2 0.3 0.8 -0.4 0.1 -0.4 -0.4 0.9
Impedance of arm (left) 0.2 0.9 3.9 -0.1 0.4 -2.0 0.7 0.1
Arm fat mass (right) 0.9 3.7 16.1 -1.5 0.6 0.4 0.0 4.0
Trunk predicted mass 0.7 3.7 11.1 -1.3 -1.2 1.5 -1.4 3.3
Standing height 0.6 5.8 13.2 -2.5 -1.0 1.2 -2.6 3.6
Length of working week for main job 0.1 0.1 0.6 -0.1 -0.8 0.2 0.1 -0.0
Exposure to tobacco smoke at home 0.6 0.7 2.5 -1.6 -0.3 0.1 -0.8 -0.5
Breastfed as a baby 1.0 1.3 2.7 -0.5 -1.7 -1.4 -0.2 -1.1
Tense / ‘highly strung’ 1.0 1.7 7.7 0.4 0.2 2.8 0.6 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.1 -0.8 -1.0 1.1 -0.6 -1.4
Hair/balding pattern: Pattern 4 0.7 1.7 3.6 -1.2 1.4 -1.9 -1.2 0.0
Birth weight of first child 0.6 1.1 2.7 -0.9 -1.6 1.3 -0.3 -0.6
Peak expiratory flow (PEF) 0.6 1.4 3.4 -1.1 -0.4 -0.8 -1.2 1.9
Pulse wave reflection index 0.4 0.5 0.8 -0.9 -0.1 0.9 -0.8 0.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.8 -0.1 -0.8 1.3 0.4 0.6
Loud music exposure frequency 0.7 0.8 2.6 -0.4 -1.6 -0.3 -1.0 0.4
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.3 0.8 0.7 0.0 1.6 1.8
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 6.6 -0.7 -0.7 0.4 0.4 2.6
Blood clot in the leg (DVT) 0.5 0.6 1.1 0.3 0.1 -1.0 1.1 -0.9
Medication: Paracetamol 0.3 0.4 0.8 -0.3 -0.8 -0.9 0.6 0.5
Headache pain in last month 0.2 0.4 1.0 -1.0 -0.9 -0.1 -0.1 0.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 0.6 -0.6 1.1 1.2 0.1
Glaucoma (self-reported) 0.1 0.1 0.3 -0.2 -0.5 0.1 -0.4 -0.5
Gout (self-reported) 1.1 1.5 3.1 -1.2 -1.8 -1.1 -1.3 0.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.2 0.5 0.8 -1.5 0.5 -0.4
Medication: Amlodipine 0.9 1.3 2.0 -1.4 -0.7 -1.3 -1.4 0.5
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.5 0.7 0.1 0.3 -0.1 -0.7
Birth weight 1.2 2.6 11.8 0.9 -0.5 3.4 -0.2 -0.1
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.6 0.9 -0.2 0.7 1.3 1.6
High blood pressure (siblings) 1.0 1.4 4.4 -0.7 -1.2 -2.1 -0.6 -0.6
Forced vital capacity (FVC), Best measure 1.2 4.4 10.5 -2.6 0.0 -0.7 -3.2 2.0
Body fat percentage 0.8 3.0 10.8 -1.7 0.9 0.6 0.2 3.3
Leg fat percentage (right) 0.4 1.3 4.1 -1.1 0.4 0.8 0.2 2.0
Arm fat-free mass (right) 0.8 4.2 9.7 -1.6 -0.8 2.4 -1.5 3.1
Exposure to tobacco smoke outside home 0.5 0.7 1.2 -0.7 1.1 -0.6 -0.2 1.1
Comparative body size at age 10 0.1 0.3 0.6 0.2 0.3 -0.8 -0.4 -0.7
Number of full brothers 0.6 0.8 1.9 -1.4 -0.0 -0.9 -1.1 0.0
Worry too long after embarrassment 0.6 1.1 2.6 -0.4 -1.4 -1.6 -0.6 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.8 -1.7 -1.3 0.7 -0.9 -0.2
Wheeze or whistling in the chest in last year 0.9 1.6 4.0 0.5 -1.9 2.0 -0.3 0.4
Number of children fathered 0.8 0.9 2.0 1.0 0.1 1.4 1.2 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.7 -1.5 -0.7 -0.9 -1.6 0.1
Age at first live birth 0.9 1.6 5.1 0.1 -1.4 2.3 -0.3 -1.0
Pulse wave peak to peak time 0.1 0.1 0.2 0.3 -0.0 0.4 0.3 -0.5
Health satisfaction 1.1 1.4 2.6 -1.6 -1.1 0.2 -1.6 0.7
Shortness of breath walking on level ground 0.6 0.8 1.9 -0.7 -0.5 -0.1 -1.1 1.4
Qualifications: College or University degree 0.6 2.0 8.7 2.9 0.8 0.1 0.6 -0.0
Eye problems/disorders: None of the above 1.0 1.1 5.1 0.1 0.0 -2.3 0.3 0.7
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.0 -0.4 -1.0 0.9 0.2 -0.1
Emphysema/chronic bronchitis 0.6 0.7 2.9 -0.1 0.1 1.7 -0.4 0.6
Medication for pain relief, constipation, heartburn 0.4 0.7 2.0 0.8 1.4 0.8 0.5 -0.2
Neck or shoulder pain in last month 0.4 0.6 1.5 0.1 -0.8 -0.5 0.7 -1.2
Medication: Blood pressure 0.1 0.2 0.5 -0.4 -0.2 -0.7 -0.6 0.1
Angina (self-reported) 1.0 1.3 3.1 1.8 -1.6 1.0 0.4 0.1
Migraine (self-reported) 1.4 1.7 4.9 -1.3 0.7 -1.2 -0.5 2.2
Medication: Ibuprofen 3.2 3.8 8.6 -2.2 -2.9 -1.4 -1.9 -0.3
Medication: Allopurinol 0.7 0.9 1.3 -1.1 -0.8 -0.4 -1.1 1.1
Medication: Omeprazole 0.3 0.3 0.6 0.0 -0.6 -0.8 -0.6 -0.6
Medication: Seretide 50 evohaler 0.6 0.7 2.2 0.8 -1.5 -0.5 0.1 -0.8
Mean time to correctly identify matches 0.2 0.3 0.7 0.6 -0.6 0.4 0.9 0.3
Heart disease (mother) 0.7 0.9 2.1 0.6 1.3 1.4 0.2 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.1 -0.0 1.5 -0.7 -0.0 -1.0
Whole body fat mass 1.0 4.1 16.1 -1.9 0.4 0.7 -0.2 4.0
Leg fat mass (right) 0.8 3.1 11.1 -1.7 0.4 1.1 -0.2 3.3
Arm predicted mass (right) 0.8 4.1 9.7 -1.4 -0.6 2.6 -1.4 3.1
Pulse rate, automated reading 0.0 0.1 0.2 -0.2 0.1 -0.4 -0.1 -0.4
Alcohol intake frequency. 0.4 0.9 2.0 0.6 0.4 -1.4 1.3 0.4
Comparative height size at age 10 0.5 2.7 5.1 -2.2 -0.7 0.6 -1.6 2.2
Number of full sisters 0.7 0.8 1.8 -1.3 -1.2 -0.0 -0.9 -0.1
Suffer from ‘nerves’ 1.5 2.3 4.2 -1.7 -2.0 0.2 -2.0 -0.7
Overall health rating 1.7 3.6 9.8 0.5 -0.5 2.5 1.1 3.1
Chest pain or discomfort 2.5 3.6 12.8 -0.7 -1.8 3.6 -1.3 0.1
Had major operations 1.6 1.9 4.7 -0.9 -0.5 -0.4 -1.9 -2.2
Age at last live birth 1.0 1.5 3.1 -0.4 -1.7 1.7 -0.7 -1.0
Family relationship satisfaction 0.7 0.8 2.7 -1.6 0.2 0.2 -0.7 0.9
Leg pain on walking 2.1 2.6 12.4 -0.5 -0.0 -0.3 0.5 3.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.1 -0.3 -1.0 0.7 -0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.1 1.4 0.4 -0.8 1.0 -0.6
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.0 1.4 0.9 -0.7 0.9 -0.5
Medication: Aspirin 0.5 0.6 2.3 0.8 -0.3 1.5 -0.3 0.3
Supplements: Vitamin C 1.4 1.7 3.6 1.2 -0.9 -1.6 1.9 -0.3
Knee pain experienced in last month 1.7 2.6 6.1 2.2 -0.7 0.1 2.5 1.3
Hypertension (Self-reported) 0.3 0.8 1.5 -1.1 0.2 0.7 -1.0 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 0.9 -0.9 -0.7 -0.3 -0.9 -0.7
Illnesses of father: Heart disease 1.7 2.4 6.0 0.9 0.2 2.1 0.7 2.4
Illnesses of siblings: Diabetes 0.7 0.9 1.5 -0.6 -1.1 0.1 -1.2 -1.1
Smoking status: Previous 2.1 3.2 6.2 -2.5 -2.1 0.8 -2.0 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.5 9.7 -3.1 -0.4 0.3 -3.0 1.9
Whole body fat-free mass 0.7 4.1 13.8 -1.5 -0.8 1.5 -1.3 3.7
Leg fat-free mass (right) 0.8 4.3 16.6 -1.7 -0.2 1.0 -1.0 4.1
Arm fat percentage (left) 0.7 2.9 12.1 -1.1 0.9 0.0 0.7 3.5
Average weekly red wine intake 0.2 0.2 0.7 0.2 -0.8 -0.4 0.0 -0.5
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.3 -1.5 -1.4 0.3 -0.5 -0.3
Mood swings 1.4 2.6 6.6 -0.2 -2.6 2.5 -0.2 0.2
Loneliness, isolation 1.6 2.2 7.6 -1.2 0.1 1.4 -0.3 2.8
Long-standing illness, disability or infirmity 0.4 0.6 1.2 0.8 -0.4 0.9 -0.2 -1.1
Ever had bowel cancer screening 1.3 1.5 5.3 -0.6 1.2 0.6 -0.1 -2.3
Diabetes diagnosed by doctor 1.2 1.9 5.0 -1.1 -0.8 1.5 0.8 2.2
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.8 -1.2 -1.1 -0.1 -0.6 -2.0
Friendships satisfaction 1.3 1.6 4.7 -1.6 -0.8 -2.2 -0.5 0.1
Qualifications: nursing, teaching 0.4 0.6 1.3 1.1 0.4 -0.1 1.1 0.6
Commuting to job workplace: Walk 0.5 0.5 0.8 0.9 0.7 0.2 0.9 0.8
Eye problems/disorders: Cataract 0.4 0.4 1.6 0.3 0.4 1.3 0.4 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.1 0.7 0.9 -0.0 1.1 0.7
Medication for cholesterol 0.4 0.6 1.5 -0.0 -0.0 -1.2 -0.3 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 6.4 0.7 0.0 0.5 1.4 2.5
Back pain experienced in last month 0.8 1.1 3.6 -0.7 0.4 1.0 -0.7 1.9
Mineral and other dietary supplements 0.1 0.1 0.2 -0.1 0.1 0.4 -0.5 0.4
Breast cancer (self-reported) 1.0 1.2 3.2 -0.3 0.3 1.6 -0.3 1.8
Asthma (self-reported) 0.3 0.5 1.1 0.2 -1.0 0.8 -0.4 -0.9
Osteoporosis (self-reported) 0.9 1.1 2.8 -1.7 -0.3 -0.6 -1.5 -0.2
Osteoarthritis (self-reported) 0.9 1.2 3.4 1.2 -0.1 1.8 1.0 0.4
Medication: Aspirin 0.4 0.6 2.0 0.7 -0.1 1.4 -0.5 0.2
Medication: Gliclazide 3.3 3.8 7.1 1.4 1.7 0.0 2.7 2.6
Illnesses of father: None of the above (group 1) 1.0 1.2 2.9 0.3 1.7 -1.1 0.9 1.1
Smoking status: Current 0.6 0.9 1.6 -0.7 -1.3 0.7 -1.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.4 -1.7 1.0 -2.3 -1.2 1.7
Whole body water mass 0.7 4.0 13.5 -1.4 -0.8 1.5 -1.3 3.7
Leg predicted mass (right) 0.8 4.3 16.8 -1.6 -0.2 1.0 -0.9 4.1
Arm fat mass (left) 1.0 3.9 16.7 -1.3 0.8 0.9 0.3 4.1
Number of self-reported non-cancer illnesses 0.2 0.3 1.0 0.0 -0.1 0.2 -0.7 -1.0
Average weekly champagne plus white wine intake 0.8 1.1 2.5 -1.6 0.1 1.0 -1.2 -0.8
Miserableness 3.1 5.4 12.2 -1.9 -3.5 3.1 -1.1 0.2
Guilty feelings 0.2 0.3 0.7 0.8 -0.5 0.4 0.7 0.1
Wears glasses or contact lenses 1.1 1.3 4.0 0.1 0.4 0.1 -1.4 -2.0
Ever taken oral contraceptive pill 0.6 0.7 2.8 -0.4 0.6 -1.7 -0.4 0.2
Hearing aid user 0.4 0.5 1.1 -0.6 -0.5 1.0 0.7 -0.4
Mother’s age at death 1.7 2.1 6.8 -0.5 -0.2 -1.8 -0.7 -2.6
Financial situation satisfaction 2.3 2.8 9.0 0.7 1.5 1.0 1.2 3.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.0 0.6 -0.4 0.8 1.0 0.4
Commuting to job workplace: Public transport 3.6 4.3 12.2 2.0 0.7 -0.4 3.5 2.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 -0.3 -0.3 0.8 -0.7 -0.5
Medication: Blood pressure 0.9 1.6 7.0 0.1 0.3 1.0 0.2 2.6
Pain type(s) experienced in last month: Hip pain 1.8 2.3 5.6 -2.1 -0.5 -2.4 -1.1 -0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 0.6 -0.2 0.6 0.6 -0.6
High cholesterol (Self-reported) 0.3 0.5 1.6 0.3 0.5 -0.8 -0.1 1.3
Medication: Bendroflumethiazide 0.1 0.2 0.8 0.2 -0.2 -0.2 0.9 -0.2
Medication: Paracetamol 0.5 0.8 2.8 -1.0 -1.7 0.1 -0.2 -0.1
Medication: Lisinopril 0.3 0.4 1.8 -0.2 -1.3 0.6 -0.2 0.2
Medication: Atorvastatin 0.3 0.4 1.1 0.5 -0.1 -0.5 0.7 -1.1
Illnesses of father: High blood pressure 1.3 1.6 4.4 -0.6 -2.1 0.9 0.2 1.5
Alcohol drinker status: Never 0.4 0.5 1.9 0.5 0.0 -1.4 0.2 0.4
Ever smoked 3.5 6.1 12.3 -2.9 -3.5 1.1 -2.6 -1.4
Basal metabolic rate 0.8 4.7 16.6 -1.6 -0.7 1.5 -1.2 4.1
Leg fat percentage (left) 0.3 1.3 4.0 -1.1 0.4 0.9 0.2 2.0
Arm fat-free mass (left) 0.8 3.8 9.7 -1.5 -0.6 2.0 -1.6 3.1
Number of operations (self-reported) 1.9 2.8 7.0 -1.6 -0.5 -0.6 -2.6 -1.9
Average weekly beer plus cider intake 2.0 2.9 9.9 1.0 0.9 -0.3 1.6 3.1
Irritability 2.3 3.9 10.3 0.2 -0.6 3.0 0.1 3.2
Risk taking 0.3 0.4 1.5 0.3 0.3 -0.4 1.2 0.0
Ever had prostate specific antigen (PSA) test 1.1 1.2 4.3 -1.1 0.1 -0.6 -0.6 -2.1
Fractured/broken bones in last 5 years 0.7 0.9 4.1 0.3 0.2 0.1 -0.1 2.0
Age started oral contraceptive pill 0.4 0.6 1.4 -0.2 1.2 -0.2 -0.5 -1.0
Diastolic blood pressure, automated reading 0.4 1.2 2.6 -0.7 1.6 0.6 -1.0 1.3
Ever depressed for a whole week 0.1 0.2 0.6 0.1 -0.4 0.8 0.1 -0.4
Unable to work because of sickness or disability 0.5 0.6 1.4 -1.0 0.5 0.5 -0.4 1.2
Commuting to job workplace: Cycle 0.4 0.5 1.0 0.9 -0.1 -0.6 1.0 0.7
Myopia 0.5 0.8 2.0 1.0 0.0 -0.7 0.6 -1.4
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.1 0.7 -0.2 -0.3 1.0 -1.0
Cholesterol lowering medication 0.4 0.5 1.4 -0.4 -0.0 -0.6 -0.8 1.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.3 -0.2 -0.2 -0.6 -0.7
Pain experienced in last month 0.2 0.3 0.8 0.1 0.5 0.9 -0.0 0.4
Supplements: Calcium 1.1 1.2 3.4 -0.1 1.8 -1.6 -0.1 -0.4
Basal cell carcinoma (self-reported) 1.6 1.8 5.2 -0.8 1.2 -1.0 -1.0 -2.3
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.1 1.1 -1.5 1.8 0.2 1.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 0.0 -0.0 -0.7 0.8 -0.4
Heart disease (siblings) 0.2 0.2 0.6 -0.2 -0.5 -0.2 -0.5 0.8
Alcohol drinker status: Previous 0.5 0.6 1.3 -0.8 0.1 1.1 -0.0 1.0
Pack years of smoking 0.5 0.8 2.2 -0.1 0.3 1.1 0.4 1.5
Impedance of whole body 0.0 0.2 0.8 -0.2 0.1 -0.9 0.3 -0.3
Leg fat mass (left) 0.8 3.0 11.1 -1.7 0.4 1.0 -0.1 3.3
Arm predicted mass (left) 0.9 4.8 10.4 -1.9 -0.6 2.5 -1.9 3.2