Hub : Genes

FGF17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.3470	0.105	0.00370	0.001	NA	0.047	NA	0.074	3.0e-01	NA	2.4e-02	NA	6.0e-03
2	GTEx	Ovary	0.3840	0.134	0.00390	-0.002	NA	0.017	NA	0.029	3.6e-01	NA	1.2e-01	NA	6.7e-02
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1870	0.077	0.00760	-0.005	NA	-0.003	NA	-0.004	8.5e-01	NA	5.5e-01	NA	6.9e-01
4	GTEx	Thyroid	0.0950	0.040	0.00530	0.108	NA	0.095	NA	0.099	1.3e-08	NA	9.7e-08	NA	5.4e-08
5	TCGA	Lung Adenocarcinoma	0.0812	0.031	0.00016	0.032	0.046	0.044	NA	0.043	1.1e-04	4.4e-06	6.3e-06	NA	9.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	1.0	2.5	0.8	0.2	1.3	-0.3	-1.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.7	0.3	0.1	0.5	-0.1	-0.8
Depressed Affect (Nagel 2018)	2.1	4.4	7.2	-2.7	-2.6	2.2	-1.4	1.2
Depression (Nagel 2018)	2.2	3.4	8.2	-2.4	-2.9	1.0	-1.3	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.2	0.5	-0.8	-0.7	-0.3
Neuroticism (Nagel 2018)	1.4	3.3	6.5	-2.4	-2.5	1.2	-1.6	0.4
Schizophrenia (2018)	0.0	0.1	0.3	-0.3	-0.1	-0.6	0.0	0.2
Schizophrenia vs Biploar Disorder	1.0	1.3	5.1	-0.1	-0.5	0.4	1.0	2.2
Worry (Nagel 2018)	1.4	3.0	6.1	-2.5	-2.4	0.5	-1.7	-0.5
Alzheimer’s Disease (in mother)	0.5	0.5	1.0	0.6	-0.5	-1.0	1.0	-0.2
Alzheimer’s Disease (in father)	2.1	2.3	6.1	-1.4	-0.2	0.3	-2.5	-1.8
Alzheimer’s Disease (including proxy)	0.4	0.5	1.8	0.7	-0.6	0.2	-0.1	-1.3
Crohns Disease (2017)	1.1	2.3	7.3	1.7	0.9	-0.1	2.7	0.8
Irritable Bowel Disease (IBD)	1.3	3.1	7.0	1.8	2.2	0.8	2.6	0.3
Ulcerative Colitis (UC)	1.0	1.9	4.5	1.1	2.1	1.2	1.6	-0.4
Major Depression (MDD)	0.6	0.7	1.4	0.7	-1.1	1.2	0.8	0.0
Reaction Time	0.5	1.0	2.1	-0.0	-1.1	1.2	0.2	1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	-0.5	0.5	-0.6	-1.7	1.2
Breast Cancer	0.3	0.6	1.2	0.6	0.6	0.6	1.1	-0.9
Ovarian Cancer	1.4	1.8	5.1	-1.3	-0.8	2.2	-0.7	-1.0
Prostate Cancer	0.8	1.1	2.4	-1.5	0.3	-0.0	-1.4	-1.0
Age at First Birth	0.5	0.7	1.8	-0.3	0.3	1.3	-0.8	-0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	0.0	1.2	-1.3	-0.5	-0.1
Coronary Artery Disease (CAD)	0.8	1.0	3.4	1.8	0.8	0.7	0.4	0.0
Crohns Disease (2012)	0.1	0.2	0.4	-0.3	-0.3	0.0	0.5	0.7
Mean Putamen Volume	0.5	0.6	2.4	-0.4	-0.1	0.3	-1.6	-0.6
Fasting Glucose	1.5	1.9	3.0	1.7	1.5	0.1	1.7	1.2
HbA1C	0.6	0.7	2.2	1.1	0.1	-0.2	0.3	1.5
HDL Cholesterol	0.6	0.9	2.0	0.6	1.4	-0.2	1.1	-1.0
LDL Cholesterol	0.4	0.7	3.0	0.4	-0.1	-0.6	-1.7	-0.2
Lupus	0.1	0.2	0.5	0.0	-0.7	-0.3	0.5	-0.1
Neuroticism (2016)	1.8	2.6	5.7	-2.4	-1.8	1.0	-1.8	-0.0
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.3	-0.4	0.4	-0.1	-0.6
Rheumatoid Arthritis	1.5	2.0	5.9	2.4	0.2	1.0	1.7	-0.1
Schizophrenia (2014)	0.2	0.4	1.0	-1.0	-0.9	0.4	-0.2	-0.4
Triglycerides	0.4	0.6	2.5	0.5	-1.6	-0.5	-0.3	0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-1.0	-1.1	-0.3	-1.1	0.0
Ulcerative Colitis	0.9	1.3	2.5	1.4	1.6	0.7	1.3	0.1
Blood Eosinophil Count	0.5	3.7	6.1	-1.4	-1.9	2.5	-1.7	-1.9
Blood Platelet Count	0.7	8.7	31.6	-1.6	1.4	-1.7	-2.1	5.6
Blood Red Count	3.4	33.1	78.3	3.5	7.8	1.0	3.5	8.8
Blood White Count	0.6	4.3	8.0	-2.8	-0.7	0.7	-2.2	2.8
Heel T-Score	0.2	1.2	3.3	1.3	0.1	-1.8	-0.1	-1.0
BMI	0.4	2.1	9.9	-0.2	0.0	0.4	0.5	3.1
Height	0.4	6.8	10.4	-3.0	-1.0	1.8	-3.2	3.2
Waist Hip Ratio (WHR)	1.2	5.4	18.9	0.9	-1.9	0.5	1.9	4.3
Systolic Blood Pressure	0.1	0.4	0.7	-0.8	0.8	0.5	-0.3	0.8
Smoking Status	2.7	6.4	9.8	-2.9	-3.1	1.7	-2.6	1.8
Allergy or Eczema	1.1	2.8	6.3	-0.7	0.9	-1.5	-2.1	-2.5
Cardiovascular Disease	0.7	2.3	8.8	-0.8	1.4	-0.1	-0.5	3.0
Hypothyroidism (self reported)	0.5	1.3	2.1	1.5	1.0	-1.1	0.8	1.1
Respiratory disease	0.6	1.2	3.0	0.3	-1.5	0.8	-0.6	-1.7
Type 2 Diabetes (T2D) (2018)	2.0	3.7	15.1	-1.0	-0.7	0.7	1.2	3.9
Lung FEV1/FVC ratio	0.4	1.8	3.8	-2.0	-1.5	0.9	0.5	1.5
Lung FVC	0.6	2.9	8.5	-0.9	0.5	-2.2	-2.9	-0.3
Neuroticism	1.5	3.7	7.7	-2.8	-2.6	1.2	-1.6	-0.0
Chronotype (morning person)	0.4	0.9	2.6	0.9	-0.2	-1.6	0.6	-1.0
Hair Pigment	0.2	4.6	11.8	-3.4	1.9	-0.3	-2.7	-0.3
Tanning	0.1	1.2	3.2	1.8	-0.6	-0.2	1.5	0.4
Hand grip strength (left)	0.3	0.8	2.1	-0.6	-0.2	1.1	-1.4	-0.6
Number of treatments/medications taken	0.9	1.6	4.5	-1.4	0.2	-1.0	-2.1	-0.5
Average weekly spirits intake	0.2	0.2	0.4	-0.1	-0.5	0.6	0.1	0.7
Sensitivity / hurt feelings	0.3	0.5	1.1	0.6	-1.0	0.5	-0.7	-0.6
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.6	-0.8	-1.9	1.2	-0.4	0.3
Hearing difficulty/problems: Yes	1.1	1.7	5.3	-0.6	-1.5	2.3	-0.2	-0.6
Relative age of first facial hair	0.7	1.4	6.7	-0.4	-0.0	0.4	-0.0	2.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	-1.0	0.5	-0.2	-1.0	-0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	-0.6	-0.1	0.6	-0.8	-1.3
Ever had hysterectomy (womb removed)	1.3	1.5	3.6	-1.2	1.4	-0.5	-1.9	-0.1
Systolic blood pressure, automated reading	0.2	0.6	1.2	-0.8	1.1	0.8	-0.3	-0.7
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.9	-0.4	-0.7	1.7	1.4	1.3
Angina	1.0	1.3	3.5	1.5	-1.9	0.8	0.3	0.1
Medication for hormone replacement therapy	0.3	0.3	0.8	0.1	-0.6	0.9	-0.4	-0.3
Vitamin and mineral supplements	0.5	0.6	2.5	-0.7	-0.4	-0.1	-1.6	-0.3
Supplements: Zinc	2.3	2.5	6.2	2.2	-0.7	0.1	2.5	-1.0
Medication: Co-codamol	0.1	0.1	0.2	0.1	-0.3	0.4	0.2	0.5
Medication: Metformin	0.6	0.8	1.3	-0.7	-0.4	0.9	1.1	1.1
Diabetes (father)	0.5	0.6	1.6	-0.3	-1.3	0.8	0.9	0.2
Diabetes (mother)	1.2	1.5	3.0	-1.1	-0.4	-1.7	-1.3	1.3
Severe depression (siblings)	0.6	0.7	1.4	0.9	0.5	0.7	1.2	0.7
Pack years adult smoking proportion	0.6	0.8	2.1	-0.5	0.2	1.4	0.1	1.5
Impedance of leg (right)	0.0	0.2	0.6	-0.4	0.0	-0.1	-0.2	-0.8
Leg fat-free mass (left)	0.9	4.9	19.3	-1.7	-0.3	1.1	-0.9	4.4
Trunk fat percentage	0.9	3.5	12.9	-1.8	1.0	0.5	0.3	3.6
Hand grip strength (right)	0.5	1.4	3.4	-0.5	-0.5	1.7	-1.8	-0.2
Townsend deprivation index at recruitment	0.4	0.6	1.7	-0.6	-0.4	1.3	0.4	0.6
Current tobacco smoking	0.7	1.1	2.0	-0.8	-1.2	0.9	-1.4	0.7
Average weekly fortified wine intake	1.8	2.1	9.1	0.6	0.9	-3.0	-0.2	-0.2
Maternal smoking around birth	1.3	1.9	6.2	-0.2	1.3	-1.2	0.3	2.5
Fed-up feelings	2.2	4.1	9.3	0.4	-0.4	3.1	1.6	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	6.6	-1.2	-2.6	2.2	-0.4	-0.0
Relative age voice broke	0.4	0.6	2.1	-0.4	-1.5	-0.5	-0.7	0.2
Taking other prescription medications	2.6	3.9	7.9	-1.4	-0.7	-1.7	-2.8	-2.6
Age when periods started (menarche)	0.5	1.3	2.2	-0.5	1.4	1.4	0.0	1.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.5	-1.6	0.2	0.2	-2.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.8	-0.2	-0.6	-1.4	-0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.1	0.2	-0.5	1.0	1.2	-1.5
Qualifications: CSEs or equivalent	0.7	1.0	2.0	0.3	-1.4	-1.4	0.0	0.9
Serious illness, injury or assault to yourself	0.4	0.5	2.0	-0.3	-0.3	-0.6	-0.0	1.4
High blood pressure	0.3	0.9	2.7	-0.9	0.4	0.4	-0.6	1.6
Hayfever, allergic rhinitis or eczema	1.0	2.2	5.3	-1.1	0.5	-0.4	-2.3	-2.0
Multivitamins +/- minerals	0.4	0.5	1.6	-0.1	-1.3	0.6	0.5	0.4
Stomach or abdominal pain in last month	1.2	1.5	3.2	-0.6	-1.1	1.5	-0.7	1.8
Supplements: Glucosamine	0.3	0.3	1.1	0.1	-0.2	-1.1	-0.7	0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.3	-0.4	0.5	0.2	0.7
Medication: Atenolol	1.8	2.3	5.9	1.5	-1.4	2.4	-0.0	-1.2
Medication: Levothyroxine sodium	0.8	1.3	3.7	1.2	0.5	-1.9	0.6	-0.9
Sitting height	1.5	10.9	22.1	-4.2	-0.5	1.5	-4.7	3.4
Chronic bronchitis/emphysema (father)	0.9	1.1	3.7	-0.0	-0.1	1.9	-1.0	-0.9
High blood pressure (mother)	0.8	1.1	2.3	-1.4	0.3	-1.5	-1.0	0.6
Body mass index (BMI)	0.5	2.1	8.1	-0.9	0.5	1.0	0.1	2.8
Impedance of leg (left)	0.1	0.3	1.4	-0.3	-0.1	-0.0	-0.3	-1.2
Leg predicted mass (left)	0.9	4.8	18.8	-1.7	-0.2	1.1	-0.9	4.3
Trunk fat mass	1.0	4.4	17.1	-2.0	0.6	0.8	-0.1	4.1
Waist circumference	1.0	3.8	17.5	-1.2	-0.1	0.3	-0.2	4.2
Number of incorrect matches in round	0.5	0.9	1.8	0.7	0.4	1.1	1.3	-1.0
Past tobacco smoking	3.1	5.8	11.4	3.4	2.9	-0.8	2.9	0.8
Alcohol usually taken with meals	1.7	2.7	8.3	1.4	1.5	0.5	0.7	-2.9
Nervous feelings	0.8	1.4	2.7	-0.9	-1.6	-0.8	-0.8	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	7.3	-0.6	-1.2	2.7	0.0	-0.0
Hearing difficulty/problems with background noise	0.6	1.0	3.5	-0.0	-1.9	0.9	-0.1	0.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.9	-0.5	1.3	1.4	0.8	0.7
Had menopause	1.0	1.3	4.9	-0.6	0.3	0.8	-0.6	-2.2
Had other major operations	1.2	1.5	4.4	-1.7	0.1	0.2	-2.1	-0.3
Forced vital capacity (FVC)	0.6	2.4	5.7	-1.6	0.0	-0.3	-2.4	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.5	-0.7	-0.1	-0.7	-0.8
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.6	0.5	1.1	0.6	0.5	1.6
Qualifications: None of the above	0.1	0.2	0.5	0.5	-0.4	-0.5	0.7	0.4
Financial difficulties in last 2 years	1.9	2.5	7.6	-1.0	0.6	1.7	0.9	2.8
Mouth/teeth dental problems	0.5	0.8	2.8	0.1	0.1	-1.7	-0.6	-0.8
Heart attack	1.2	1.6	3.1	1.0	-1.6	1.8	-0.1	1.1
Allergy	0.5	1.1	4.3	0.2	-0.5	0.3	1.0	2.1
Pain all over the body in last month	1.5	1.6	2.4	1.2	-1.3	1.5	1.5	-0.4
Diabetes (self-reported)	1.0	1.5	3.7	-0.8	-0.2	1.5	1.0	1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.7	0.9	-0.1	0.1	0.1
Medication: Ramipril	0.5	0.6	1.5	0.2	1.0	0.8	-0.2	1.2
Medication: Simvastatin	0.4	0.5	1.0	0.6	1.0	-0.6	-0.2	1.0
Fluid intelligence score	0.1	0.3	0.9	0.1	0.5	-0.3	-1.0	-0.2
Illnesses of siblings	0.7	1.0	2.1	0.7	1.4	1.0	0.8	0.9
Neuroticism score	1.1	2.2	4.1	-1.6	-2.0	1.7	-1.2	-0.2
Weight	1.0	4.8	17.8	-1.9	-0.1	1.3	-1.0	4.2
Impedance of arm (right)	0.3	1.6	7.1	-0.4	0.4	-2.7	0.6	0.2
Arm fat percentage (right)	0.7	2.7	10.8	-1.1	0.9	-0.3	0.6	3.3
Trunk fat-free mass	0.6	3.6	10.5	-1.3	-1.2	1.5	-1.4	3.2
Hip circumference	0.9	4.0	9.1	-2.5	0.8	0.3	-2.0	3.0
Time employed in main current job	0.5	0.6	1.5	0.7	1.2	-0.3	0.8	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.2	-0.5	-1.0	0.2	0.1
Father’s age at death	1.2	1.6	5.3	-0.6	1.2	0.5	-0.8	-2.3
Worrier / anxious feelings	0.6	1.1	2.0	-1.2	-1.2	-0.2	-1.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	11.1	-1.1	-2.2	3.3	-0.2	1.0
Falls in the last year	1.0	1.3	2.7	1.3	-0.7	0.3	1.6	1.3
Hair/balding pattern: Pattern 3	1.3	1.9	5.5	0.8	-2.3	-1.1	-0.5	-1.3
Number of live births	0.5	0.7	1.7	1.3	-0.1	0.1	1.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.8	-1.7	-0.2	-0.3	-1.8	2.4
Pulse rate	0.7	1.1	3.4	-1.8	-0.9	-0.1	0.0	1.2
Happiness	0.7	0.9	1.7	1.3	-0.3	1.2	1.0	0.5
Noisy workplace	1.5	1.8	3.6	0.8	0.2	1.9	1.2	1.8
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.8	1.9	0.8	-1.3	1.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-1.3	-0.2	-0.3	-0.8	1.2
Mouth/teeth dental problems: Dentures	0.6	1.1	4.9	-0.2	-0.2	2.2	-0.3	-0.7
Asthma	0.3	0.6	1.0	0.1	-1.0	0.8	-0.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.8	-1.3	-2.4	-1.8	-0.9	-0.2
Medication: Cholesterol lowering	0.3	0.5	1.4	0.1	0.8	-1.2	-0.5	0.2
Depression (self-reported)	0.3	0.3	0.9	-0.0	-1.0	-0.4	-0.2	0.8
Medication: Lansoprazole	0.9	1.1	3.0	-0.6	0.4	-1.7	-1.4	0.2
Prospective memory result	0.4	0.5	0.7	-0.4	-0.7	0.9	0.8	-0.4
Lung cancer (father)	0.4	0.5	1.3	-1.0	0.3	-0.5	-1.1	0.3
Illnesses of mother	0.4	0.5	1.0	-0.2	-0.5	0.9	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	8.3	-2.9	-0.3	-0.9	-2.7	2.3
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	-0.4	0.1	-0.4	-0.4	0.9
Impedance of arm (left)	0.2	0.9	3.9	-0.1	0.4	-2.0	0.7	0.1
Arm fat mass (right)	0.9	3.7	16.1	-1.5	0.6	0.4	0.0	4.0
Trunk predicted mass	0.7	3.7	11.1	-1.3	-1.2	1.5	-1.4	3.3
Standing height	0.6	5.8	13.2	-2.5	-1.0	1.2	-2.6	3.6
Length of working week for main job	0.1	0.1	0.6	-0.1	-0.8	0.2	0.1	-0.0
Exposure to tobacco smoke at home	0.6	0.7	2.5	-1.6	-0.3	0.1	-0.8	-0.5
Breastfed as a baby	1.0	1.3	2.7	-0.5	-1.7	-1.4	-0.2	-1.1
Tense / ‘highly strung’	1.0	1.7	7.7	0.4	0.2	2.8	0.6	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.1	-0.8	-1.0	1.1	-0.6	-1.4
Hair/balding pattern: Pattern 4	0.7	1.7	3.6	-1.2	1.4	-1.9	-1.2	0.0
Birth weight of first child	0.6	1.1	2.7	-0.9	-1.6	1.3	-0.3	-0.6
Peak expiratory flow (PEF)	0.6	1.4	3.4	-1.1	-0.4	-0.8	-1.2	1.9
Pulse wave reflection index	0.4	0.5	0.8	-0.9	-0.1	0.9	-0.8	0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	-0.1	-0.8	1.3	0.4	0.6
Loud music exposure frequency	0.7	0.8	2.6	-0.4	-1.6	-0.3	-1.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.3	0.8	0.7	0.0	1.6	1.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	6.6	-0.7	-0.7	0.4	0.4	2.6
Blood clot in the leg (DVT)	0.5	0.6	1.1	0.3	0.1	-1.0	1.1	-0.9
Medication: Paracetamol	0.3	0.4	0.8	-0.3	-0.8	-0.9	0.6	0.5
Headache pain in last month	0.2	0.4	1.0	-1.0	-0.9	-0.1	-0.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	0.6	-0.6	1.1	1.2	0.1
Glaucoma (self-reported)	0.1	0.1	0.3	-0.2	-0.5	0.1	-0.4	-0.5
Gout (self-reported)	1.1	1.5	3.1	-1.2	-1.8	-1.1	-1.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.2	0.5	0.8	-1.5	0.5	-0.4
Medication: Amlodipine	0.9	1.3	2.0	-1.4	-0.7	-1.3	-1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.7	0.1	0.3	-0.1	-0.7
Birth weight	1.2	2.6	11.8	0.9	-0.5	3.4	-0.2	-0.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.6	0.9	-0.2	0.7	1.3	1.6
High blood pressure (siblings)	1.0	1.4	4.4	-0.7	-1.2	-2.1	-0.6	-0.6
Forced vital capacity (FVC), Best measure	1.2	4.4	10.5	-2.6	0.0	-0.7	-3.2	2.0
Body fat percentage	0.8	3.0	10.8	-1.7	0.9	0.6	0.2	3.3
Leg fat percentage (right)	0.4	1.3	4.1	-1.1	0.4	0.8	0.2	2.0
Arm fat-free mass (right)	0.8	4.2	9.7	-1.6	-0.8	2.4	-1.5	3.1
Exposure to tobacco smoke outside home	0.5	0.7	1.2	-0.7	1.1	-0.6	-0.2	1.1
Comparative body size at age 10	0.1	0.3	0.6	0.2	0.3	-0.8	-0.4	-0.7
Number of full brothers	0.6	0.8	1.9	-1.4	-0.0	-0.9	-1.1	0.0
Worry too long after embarrassment	0.6	1.1	2.6	-0.4	-1.4	-1.6	-0.6	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	-1.7	-1.3	0.7	-0.9	-0.2
Wheeze or whistling in the chest in last year	0.9	1.6	4.0	0.5	-1.9	2.0	-0.3	0.4
Number of children fathered	0.8	0.9	2.0	1.0	0.1	1.4	1.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.7	-1.5	-0.7	-0.9	-1.6	0.1
Age at first live birth	0.9	1.6	5.1	0.1	-1.4	2.3	-0.3	-1.0
Pulse wave peak to peak time	0.1	0.1	0.2	0.3	-0.0	0.4	0.3	-0.5
Health satisfaction	1.1	1.4	2.6	-1.6	-1.1	0.2	-1.6	0.7
Shortness of breath walking on level ground	0.6	0.8	1.9	-0.7	-0.5	-0.1	-1.1	1.4
Qualifications: College or University degree	0.6	2.0	8.7	2.9	0.8	0.1	0.6	-0.0
Eye problems/disorders: None of the above	1.0	1.1	5.1	0.1	0.0	-2.3	0.3	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.4	-1.0	0.9	0.2	-0.1
Emphysema/chronic bronchitis	0.6	0.7	2.9	-0.1	0.1	1.7	-0.4	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	2.0	0.8	1.4	0.8	0.5	-0.2
Neck or shoulder pain in last month	0.4	0.6	1.5	0.1	-0.8	-0.5	0.7	-1.2
Medication: Blood pressure	0.1	0.2	0.5	-0.4	-0.2	-0.7	-0.6	0.1
Angina (self-reported)	1.0	1.3	3.1	1.8	-1.6	1.0	0.4	0.1
Migraine (self-reported)	1.4	1.7	4.9	-1.3	0.7	-1.2	-0.5	2.2
Medication: Ibuprofen	3.2	3.8	8.6	-2.2	-2.9	-1.4	-1.9	-0.3
Medication: Allopurinol	0.7	0.9	1.3	-1.1	-0.8	-0.4	-1.1	1.1
Medication: Omeprazole	0.3	0.3	0.6	0.0	-0.6	-0.8	-0.6	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	2.2	0.8	-1.5	-0.5	0.1	-0.8
Mean time to correctly identify matches	0.2	0.3	0.7	0.6	-0.6	0.4	0.9	0.3
Heart disease (mother)	0.7	0.9	2.1	0.6	1.3	1.4	0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.1	-0.0	1.5	-0.7	-0.0	-1.0
Whole body fat mass	1.0	4.1	16.1	-1.9	0.4	0.7	-0.2	4.0
Leg fat mass (right)	0.8	3.1	11.1	-1.7	0.4	1.1	-0.2	3.3
Arm predicted mass (right)	0.8	4.1	9.7	-1.4	-0.6	2.6	-1.4	3.1
Pulse rate, automated reading	0.0	0.1	0.2	-0.2	0.1	-0.4	-0.1	-0.4
Alcohol intake frequency.	0.4	0.9	2.0	0.6	0.4	-1.4	1.3	0.4
Comparative height size at age 10	0.5	2.7	5.1	-2.2	-0.7	0.6	-1.6	2.2
Number of full sisters	0.7	0.8	1.8	-1.3	-1.2	-0.0	-0.9	-0.1
Suffer from ‘nerves’	1.5	2.3	4.2	-1.7	-2.0	0.2	-2.0	-0.7
Overall health rating	1.7	3.6	9.8	0.5	-0.5	2.5	1.1	3.1
Chest pain or discomfort	2.5	3.6	12.8	-0.7	-1.8	3.6	-1.3	0.1
Had major operations	1.6	1.9	4.7	-0.9	-0.5	-0.4	-1.9	-2.2
Age at last live birth	1.0	1.5	3.1	-0.4	-1.7	1.7	-0.7	-1.0
Family relationship satisfaction	0.7	0.8	2.7	-1.6	0.2	0.2	-0.7	0.9
Leg pain on walking	2.1	2.6	12.4	-0.5	-0.0	-0.3	0.5	3.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.3	-1.0	0.7	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	1.4	0.4	-0.8	1.0	-0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.0	1.4	0.9	-0.7	0.9	-0.5
Medication: Aspirin	0.5	0.6	2.3	0.8	-0.3	1.5	-0.3	0.3
Supplements: Vitamin C	1.4	1.7	3.6	1.2	-0.9	-1.6	1.9	-0.3
Knee pain experienced in last month	1.7	2.6	6.1	2.2	-0.7	0.1	2.5	1.3
Hypertension (Self-reported)	0.3	0.8	1.5	-1.1	0.2	0.7	-1.0	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.9	-0.9	-0.7	-0.3	-0.9	-0.7
Illnesses of father: Heart disease	1.7	2.4	6.0	0.9	0.2	2.1	0.7	2.4
Illnesses of siblings: Diabetes	0.7	0.9	1.5	-0.6	-1.1	0.1	-1.2	-1.1
Smoking status: Previous	2.1	3.2	6.2	-2.5	-2.1	0.8	-2.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	9.7	-3.1	-0.4	0.3	-3.0	1.9
Whole body fat-free mass	0.7	4.1	13.8	-1.5	-0.8	1.5	-1.3	3.7
Leg fat-free mass (right)	0.8	4.3	16.6	-1.7	-0.2	1.0	-1.0	4.1
Arm fat percentage (left)	0.7	2.9	12.1	-1.1	0.9	0.0	0.7	3.5
Average weekly red wine intake	0.2	0.2	0.7	0.2	-0.8	-0.4	0.0	-0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.3	-1.5	-1.4	0.3	-0.5	-0.3
Mood swings	1.4	2.6	6.6	-0.2	-2.6	2.5	-0.2	0.2
Loneliness, isolation	1.6	2.2	7.6	-1.2	0.1	1.4	-0.3	2.8
Long-standing illness, disability or infirmity	0.4	0.6	1.2	0.8	-0.4	0.9	-0.2	-1.1
Ever had bowel cancer screening	1.3	1.5	5.3	-0.6	1.2	0.6	-0.1	-2.3
Diabetes diagnosed by doctor	1.2	1.9	5.0	-1.1	-0.8	1.5	0.8	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	-1.2	-1.1	-0.1	-0.6	-2.0
Friendships satisfaction	1.3	1.6	4.7	-1.6	-0.8	-2.2	-0.5	0.1
Qualifications: nursing, teaching	0.4	0.6	1.3	1.1	0.4	-0.1	1.1	0.6
Commuting to job workplace: Walk	0.5	0.5	0.8	0.9	0.7	0.2	0.9	0.8
Eye problems/disorders: Cataract	0.4	0.4	1.6	0.3	0.4	1.3	0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	0.7	0.9	-0.0	1.1	0.7
Medication for cholesterol	0.4	0.6	1.5	-0.0	-0.0	-1.2	-0.3	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	6.4	0.7	0.0	0.5	1.4	2.5
Back pain experienced in last month	0.8	1.1	3.6	-0.7	0.4	1.0	-0.7	1.9
Mineral and other dietary supplements	0.1	0.1	0.2	-0.1	0.1	0.4	-0.5	0.4
Breast cancer (self-reported)	1.0	1.2	3.2	-0.3	0.3	1.6	-0.3	1.8
Asthma (self-reported)	0.3	0.5	1.1	0.2	-1.0	0.8	-0.4	-0.9
Osteoporosis (self-reported)	0.9	1.1	2.8	-1.7	-0.3	-0.6	-1.5	-0.2
Osteoarthritis (self-reported)	0.9	1.2	3.4	1.2	-0.1	1.8	1.0	0.4
Medication: Aspirin	0.4	0.6	2.0	0.7	-0.1	1.4	-0.5	0.2
Medication: Gliclazide	3.3	3.8	7.1	1.4	1.7	0.0	2.7	2.6
Illnesses of father: None of the above (group 1)	1.0	1.2	2.9	0.3	1.7	-1.1	0.9	1.1
Smoking status: Current	0.6	0.9	1.6	-0.7	-1.3	0.7	-1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.4	-1.7	1.0	-2.3	-1.2	1.7
Whole body water mass	0.7	4.0	13.5	-1.4	-0.8	1.5	-1.3	3.7
Leg predicted mass (right)	0.8	4.3	16.8	-1.6	-0.2	1.0	-0.9	4.1
Arm fat mass (left)	1.0	3.9	16.7	-1.3	0.8	0.9	0.3	4.1
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	0.0	-0.1	0.2	-0.7	-1.0
Average weekly champagne plus white wine intake	0.8	1.1	2.5	-1.6	0.1	1.0	-1.2	-0.8
Miserableness	3.1	5.4	12.2	-1.9	-3.5	3.1	-1.1	0.2
Guilty feelings	0.2	0.3	0.7	0.8	-0.5	0.4	0.7	0.1
Wears glasses or contact lenses	1.1	1.3	4.0	0.1	0.4	0.1	-1.4	-2.0
Ever taken oral contraceptive pill	0.6	0.7	2.8	-0.4	0.6	-1.7	-0.4	0.2
Hearing aid user	0.4	0.5	1.1	-0.6	-0.5	1.0	0.7	-0.4
Mother’s age at death	1.7	2.1	6.8	-0.5	-0.2	-1.8	-0.7	-2.6
Financial situation satisfaction	2.3	2.8	9.0	0.7	1.5	1.0	1.2	3.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.6	-0.4	0.8	1.0	0.4
Commuting to job workplace: Public transport	3.6	4.3	12.2	2.0	0.7	-0.4	3.5	2.1
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.3	-0.3	0.8	-0.7	-0.5
Medication: Blood pressure	0.9	1.6	7.0	0.1	0.3	1.0	0.2	2.6
Pain type(s) experienced in last month: Hip pain	1.8	2.3	5.6	-2.1	-0.5	-2.4	-1.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.6	-0.2	0.6	0.6	-0.6
High cholesterol (Self-reported)	0.3	0.5	1.6	0.3	0.5	-0.8	-0.1	1.3
Medication: Bendroflumethiazide	0.1	0.2	0.8	0.2	-0.2	-0.2	0.9	-0.2
Medication: Paracetamol	0.5	0.8	2.8	-1.0	-1.7	0.1	-0.2	-0.1
Medication: Lisinopril	0.3	0.4	1.8	-0.2	-1.3	0.6	-0.2	0.2
Medication: Atorvastatin	0.3	0.4	1.1	0.5	-0.1	-0.5	0.7	-1.1
Illnesses of father: High blood pressure	1.3	1.6	4.4	-0.6	-2.1	0.9	0.2	1.5
Alcohol drinker status: Never	0.4	0.5	1.9	0.5	0.0	-1.4	0.2	0.4
Ever smoked	3.5	6.1	12.3	-2.9	-3.5	1.1	-2.6	-1.4
Basal metabolic rate	0.8	4.7	16.6	-1.6	-0.7	1.5	-1.2	4.1
Leg fat percentage (left)	0.3	1.3	4.0	-1.1	0.4	0.9	0.2	2.0
Arm fat-free mass (left)	0.8	3.8	9.7	-1.5	-0.6	2.0	-1.6	3.1
Number of operations (self-reported)	1.9	2.8	7.0	-1.6	-0.5	-0.6	-2.6	-1.9
Average weekly beer plus cider intake	2.0	2.9	9.9	1.0	0.9	-0.3	1.6	3.1
Irritability	2.3	3.9	10.3	0.2	-0.6	3.0	0.1	3.2
Risk taking	0.3	0.4	1.5	0.3	0.3	-0.4	1.2	0.0
Ever had prostate specific antigen (PSA) test	1.1	1.2	4.3	-1.1	0.1	-0.6	-0.6	-2.1
Fractured/broken bones in last 5 years	0.7	0.9	4.1	0.3	0.2	0.1	-0.1	2.0
Age started oral contraceptive pill	0.4	0.6	1.4	-0.2	1.2	-0.2	-0.5	-1.0
Diastolic blood pressure, automated reading	0.4	1.2	2.6	-0.7	1.6	0.6	-1.0	1.3
Ever depressed for a whole week	0.1	0.2	0.6	0.1	-0.4	0.8	0.1	-0.4
Unable to work because of sickness or disability	0.5	0.6	1.4	-1.0	0.5	0.5	-0.4	1.2
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.9	-0.1	-0.6	1.0	0.7
Myopia	0.5	0.8	2.0	1.0	0.0	-0.7	0.6	-1.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	0.7	-0.2	-0.3	1.0	-1.0
Cholesterol lowering medication	0.4	0.5	1.4	-0.4	-0.0	-0.6	-0.8	1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.3	-0.2	-0.2	-0.6	-0.7
Pain experienced in last month	0.2	0.3	0.8	0.1	0.5	0.9	-0.0	0.4
Supplements: Calcium	1.1	1.2	3.4	-0.1	1.8	-1.6	-0.1	-0.4
Basal cell carcinoma (self-reported)	1.6	1.8	5.2	-0.8	1.2	-1.0	-1.0	-2.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.1	1.1	-1.5	1.8	0.2	1.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.0	-0.0	-0.7	0.8	-0.4
Heart disease (siblings)	0.2	0.2	0.6	-0.2	-0.5	-0.2	-0.5	0.8
Alcohol drinker status: Previous	0.5	0.6	1.3	-0.8	0.1	1.1	-0.0	1.0
Pack years of smoking	0.5	0.8	2.2	-0.1	0.3	1.1	0.4	1.5
Impedance of whole body	0.0	0.2	0.8	-0.2	0.1	-0.9	0.3	-0.3
Leg fat mass (left)	0.8	3.0	11.1	-1.7	0.4	1.0	-0.1	3.3
Arm predicted mass (left)	0.9	4.8	10.4	-1.9	-0.6	2.5	-1.9	3.2