TWAS hub - IKBKB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.299	0.1080	0.0037	-0.011	NA	0.000	NA	-0.011	0.900	NA	0.3100	NA	0.780
2	TCGA	Cervical Squamous Cell Carcinoma	0.095	0.0510	0.0096	0.012	0.027	0.051	NA	0.019	0.083	0.016	0.0016	NA	0.037
3	TCGA	Lung Adenocarcinoma	0.023	0.0165	0.0087	0.012	0.013	0.002	NA	0.004	0.013	0.010	0.1900	NA	0.098

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Eye problems/disorders: Glaucoma	6.6	7.8	17.5	4.2	2.4
Commuting to job workplace: Car/motor vehicle	4.1	4.6	8.1	-2.4	-2.8
Glaucoma (self-reported)	3.9	4.5	9.9	3.1	1.9
Eye problems/disorders: None of the above	3.8	4.4	8.8	-3.0	-2.1
HbA1C	3.3	3.7	6.7	2.6	2.1
Alcohol usually taken with meals	3.2	5.1	10.4	-3.2	-2.2
Commuting to job workplace: Cycle	3.2	3.9	6.4	2.3	2.5
Health satisfaction	2.6	3.4	7.8	-1.6	-2.8
Neuroticism (2016)	2.5	3.6	10.0	3.2	0.9
Had other major operations	2.4	3.0	8.5	-0.6	-2.9
Number of full sisters	2.4	3.0	5.2	2.3	1.9
Commuting to job workplace: Walk	2.4	2.6	5.0	2.2	1.7
Breast cancer (self-reported)	2.2	2.7	4.9	-2.2	-1.8
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	5.1	-0.9	-2.3
Noisy workplace	1.8	2.2	6.6	2.6	0.3
Long-standing illness, disability or infirmity	1.8	2.8	8.3	0.4	-2.9
Alzheimer’s Disease (in father)	1.7	1.8	5.0	-2.2	-0.7
Loud music exposure frequency	1.7	1.8	4.6	2.1	0.9
Handedness (chirality/laterality): Left-handed	1.7	2.0	6.0	-2.4	-0.0
Illnesses of father: None of the above (group 1)	1.7	2.1	4.5	1.3	2.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.6	-0.8	-2.4
Number of children fathered	1.6	1.8	5.3	0.3	2.3
Diastolic blood pressure, automated reading	1.6	4.8	10.1	-3.2	-2.1
Medication for hormone replacement therapy	1.5	1.7	2.8	1.7	1.5
Loneliness, isolation	1.5	2.1	4.5	1.4	-2.1
Primary Biliary Cirrhosis	1.4	2.0	3.8	1.4	-2.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	3.6	-1.3	-1.9
Osteoarthritis (self-reported)	1.4	1.8	4.2	-1.1	-2.0
Myopia	1.4	2.1	3.3	-1.7	-1.8
Number of treatments/medications taken	1.3	2.3	6.5	2.5	0.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	4.8	-0.4	-2.2
Number of incorrect matches in round	1.3	2.2	4.5	-2.1	-1.5
Length of working week for main job	1.3	1.4	4.0	-2.0	-0.5
Medication: Omeprazole	1.3	1.6	4.7	-0.4	-2.2
Average weekly red wine intake	1.3	2.0	3.7	-1.5	-1.9
Schizophrenia vs Biploar Disorder	1.2	1.6	4.1	2.0	0.8
Blood Red Count	1.2	11.6	30.0	-5.5	-2.2
Hair/balding pattern: Pattern 3	1.2	1.8	4.8	-0.8	-2.2
Qualifications: A levels/AS levels or equivalent	1.2	2.5	7.5	-2.7	-0.4
Eye problems/disorders: Cataract	1.2	1.4	3.9	2.0	0.6
Mean Putamen Volume	1.1	1.3	2.4	1.5	1.2
Severe depression (siblings)	1.1	1.2	2.6	-1.0	-1.6
Pulse rate	1.1	1.9	3.7	-1.4	-1.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.6	-1.2	-1.6
Heart disease (mother)	1.1	1.3	2.9	-1.1	-1.7
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.2	1.1	1.8
Bipolar Disorder (2011)	1.0	1.0	2.5	-1.6	-0.8
Hair/balding pattern: Pattern 2	1.0	1.3	3.9	-0.0	2.0
Pain all over the body in last month	1.0	1.1	2.6	-0.8	-1.6
Alcohol intake versus 10 years previously	1.0	1.5	4.0	2.0	-0.7
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.0	1.7	1.6
Knee pain experienced in last month	1.0	1.5	3.0	-1.2	-1.7
Coronary Artery Disease (CAD)	0.9	1.1	3.3	0.2	-1.8
Townsend deprivation index at recruitment	0.9	1.3	3.6	1.9	0.6
Mouth/teeth dental problems	0.9	1.4	4.0	-2.0	-0.5
High blood pressure (siblings)	0.9	1.3	3.1	1.7	0.9
Shortness of breath walking on level ground	0.9	1.1	2.7	-0.7	-1.6
Leg pain on walking	0.9	1.1	3.2	0.3	-1.8
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.1	1.8	-0.4
Heart disease (siblings)	0.9	1.1	2.8	0.8	-1.7
LDL Cholesterol	0.8	1.3	3.4	-1.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.0	-1.4	-1.0
Medication: Atenolol	0.8	1.0	2.7	0.6	1.6
Arm fat percentage (right)	0.8	3.0	8.9	-0.4	-3.0
Lung cancer (father)	0.8	0.9	2.7	0.2	1.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.6	0.3	1.6
Number of operations (self-reported)	0.8	1.1	3.4	0.3	-1.8
Schizophrenia (2018)	0.7	1.5	3.3	1.1	1.8
Worry (Nagel 2018)	0.7	1.5	3.1	1.8	1.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	1.2	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	3.5	1.9	0.1
Arm fat mass (right)	0.7	3.0	8.6	-0.6	-2.9
Wheeze or whistling in the chest in last year	0.7	1.3	2.3	-1.5	-1.3
Neck or shoulder pain in last month	0.7	1.0	2.6	-0.7	-1.6
Medication: Allopurinol	0.7	1.0	2.4	0.8	1.5
Overall health rating	0.7	1.4	3.6	1.9	-0.8
Age at last live birth	0.7	1.0	1.9	-1.4	-1.0
Arm fat percentage (left)	0.7	2.8	8.5	-0.2	-2.9
Mineral and other dietary supplements	0.7	1.0	1.8	-1.4	-1.1
Medication: Atorvastatin	0.7	0.9	1.4	-1.1	-1.2
Risk taking	0.7	1.0	2.3	0.9	1.5
Age started oral contraceptive pill	0.7	0.9	1.9	-1.4	-0.9
Supplements: Calcium	0.7	0.7	1.3	1.0	1.1
Hypothyroidism (self reported)	0.6	1.3	2.5	1.2	1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.1	0.3	-1.5
Body mass index (BMI)	0.6	2.7	7.0	-1.1	-2.7
Hearing difficulty/problems with background noise	0.6	1.0	1.6	1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	5.4	2.3	0.2
Tense / ‘highly strung’	0.6	1.0	2.6	1.6	0.6
Medication: Amlodipine	0.6	0.8	1.3	1.1	1.0
Medication: Blood pressure	0.6	1.1	2.6	1.6	0.9
Migraine (self-reported)	0.6	0.7	1.5	-1.2	-0.7
Whole body fat mass	0.6	2.4	7.2	0.1	-2.7
Supplements: Vitamin C	0.6	0.7	1.6	-0.7	1.3
Illnesses of father: Heart disease	0.6	0.8	2.3	-0.2	-1.5
Ever had bowel cancer screening	0.6	0.7	1.8	0.5	-1.3
Diabetes diagnosed by doctor	0.6	0.9	2.8	-0.3	-1.7
Arm fat mass (left)	0.6	2.7	7.8	-0.4	-2.8
Number of self-reported non-cancer illnesses	0.6	1.0	2.8	1.7	-0.5
Fractured/broken bones in last 5 years	0.6	0.7	1.3	-0.9	1.1
Unable to work because of sickness or disability	0.6	0.8	2.4	-0.2	-1.5
Impedance of whole body	0.6	2.8	6.0	2.5	1.6
Bipolar Disorder (2018)	0.5	0.8	2.0	-1.4	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.7	-1.6	-0.8
Lupus	0.5	0.7	2.0	0.4	-1.4
Triglycerides	0.5	0.8	2.3	0.4	1.5
Trunk fat percentage	0.5	2.1	5.2	1.1	-2.3
Supplements: Glucosamine	0.5	0.6	1.6	0.5	-1.3
Impedance of leg (left)	0.5	2.5	5.0	1.6	2.2
Trunk fat mass	0.5	2.3	6.6	0.6	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.7	1.3	0.3
Impedance of arm (left)	0.5	2.2	6.4	2.5	0.5
Exposure to tobacco smoke at home	0.5	0.6	1.8	0.2	-1.3
Birth weight of first child	0.5	0.9	2.7	0.3	1.6
Pulse wave reflection index	0.5	0.6	1.4	-0.6	1.2
Forced vital capacity (FVC), Best measure	0.5	1.9	5.7	2.4	0.2
Body fat percentage	0.5	2.0	5.9	0.4	-2.4
Leg fat percentage (right)	0.5	1.9	5.7	-0.4	-2.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	0.1	1.3
Emphysema/chronic bronchitis	0.5	0.6	1.2	-0.7	-1.1
Leg fat mass (right)	0.5	1.9	5.7	-0.2	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-1.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.9	-1.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.1	0.4	-1.8
Medication: Aspirin	0.5	0.7	2.0	1.4	0.3
Smoking status: Current	0.5	0.7	1.4	1.2	-0.9
Ever taken oral contraceptive pill	0.5	0.5	1.6	-0.2	-1.3
Illnesses of father: High blood pressure	0.5	0.6	1.1	1.1	-0.8
Leg fat percentage (left)	0.5	1.8	5.0	-0.6	-2.2
Pain experienced in last month	0.5	0.9	1.4	1.2	1.2
Depression (Nagel 2018)	0.4	0.7	1.3	-0.8	-1.2
Major Depression (MDD)	0.4	0.5	1.1	1.1	-0.5
Ovarian Cancer	0.4	0.6	0.9	1.0	0.9
Fasting Glucose	0.4	0.5	1.1	-0.7	1.1
Schizophrenia (2014)	0.4	0.9	2.7	0.1	1.6
Impedance of leg (right)	0.4	1.9	3.5	1.5	1.9
Current tobacco smoking	0.4	0.7	1.2	1.1	-0.9
Medication: Levothyroxine sodium	0.4	0.7	1.4	0.9	1.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	-1.1	-0.1
Waist circumference	0.4	1.4	4.1	-0.3	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.1	1.4	-0.1
Illnesses of siblings	0.4	0.6	1.3	-1.1	0.7
Weight	0.4	2.1	6.2	-0.5	-2.5
Medication: Paracetamol	0.4	0.7	1.8	1.3	-0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.8	-1.3	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.1	1.0	-0.7
Age at first live birth	0.4	0.6	1.7	-1.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	1.2	-0.0
Medication: Aspirin	0.4	0.5	1.4	1.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.8	1.4	-0.5
Medication for cholesterol	0.4	0.7	2.0	-1.4	-0.0
Mother’s age at death	0.4	0.5	1.1	0.5	-1.0
Average weekly beer plus cider intake	0.4	0.6	1.0	-1.0	-0.9
Leg fat mass (left)	0.4	1.6	4.7	-0.3	-2.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	-1.1	0.2
Crohns Disease (2017)	0.3	0.7	2.1	0.3	-1.4
Breast Cancer	0.3	0.7	1.9	1.4	0.5
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.0	-1.1
BMI	0.3	1.7	3.1	-1.4	-1.8
Respiratory disease	0.3	0.6	1.5	0.5	-1.2
Lung FVC	0.3	1.6	2.9	1.7	1.4
Chronotype (morning person)	0.3	0.6	1.2	0.8	1.1
Sensitivity / hurt feelings	0.3	0.6	1.8	1.3	-0.0
Relative age of first facial hair	0.3	0.5	1.3	0.5	-1.1
Systolic blood pressure, automated reading	0.3	0.9	2.3	-1.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	-0.9	-0.2
Medication: Metformin	0.3	0.4	0.7	0.7	-0.8
Leg fat-free mass (left)	0.3	1.6	4.8	-0.3	-2.2
Multivitamins +/- minerals	0.3	0.3	1.0	-1.0	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	-0.5	0.9
Leg predicted mass (left)	0.3	1.6	4.8	-0.2	-2.2
Forced vital capacity (FVC)	0.3	1.1	2.6	1.6	0.9
Financial difficulties in last 2 years	0.3	0.4	1.1	1.1	-0.1
Diabetes (self-reported)	0.3	0.4	1.3	0.1	-1.1
Neuroticism score	0.3	0.5	1.4	1.2	0.5
Trunk fat-free mass	0.3	1.5	2.8	-1.3	-1.7
Worrier / anxious feelings	0.3	0.6	1.6	1.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	1.1	-0.5
Happiness	0.3	0.3	0.9	0.1	-1.0
Asthma	0.3	0.5	1.3	1.2	-0.4
Illnesses of mother	0.3	0.4	1.2	1.1	-0.0
Hair/balding pattern: Pattern 4	0.3	0.7	2.1	0.4	-1.4
Peak expiratory flow (PEF)	0.3	0.7	1.9	1.4	0.3
Birth weight	0.3	0.7	2.1	1.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	0.9	-0.4
Pulse wave peak to peak time	0.3	0.4	1.1	1.0	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	-1.2	0.5
Medication: Ibuprofen	0.3	0.3	0.9	1.0	0.0
Alcohol intake frequency.	0.3	0.6	1.8	1.3	0.1
Whole body fat-free mass	0.3	1.4	3.6	-0.8	-1.9
Leg fat-free mass (right)	0.3	1.5	4.4	-0.2	-2.1
Mood swings	0.3	0.5	1.1	0.7	1.1
Qualifications: nursing, teaching	0.3	0.5	1.3	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.1	0.7	1.1
Whole body water mass	0.3	1.4	3.6	-0.8	-1.9
Leg predicted mass (right)	0.3	1.4	4.1	-0.1	-2.0
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.9	-0.7
Hearing aid user	0.3	0.4	0.6	-0.8	0.7
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.8	0.6
High cholesterol (Self-reported)	0.3	0.5	1.0	1.0	0.6
Medication: Paracetamol	0.3	0.4	0.9	0.5	-1.0
Medication: Lisinopril	0.3	0.4	1.0	1.0	0.5
Basal metabolic rate	0.3	1.6	4.4	-0.7	-2.1
Pack years of smoking	0.3	0.5	1.3	0.4	-1.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	-0.0	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	-1.3	0.4
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.3	0.8
Age at First Birth	0.2	0.3	0.7	-0.4	0.8
Rheumatoid Arthritis	0.2	0.2	0.6	0.8	0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	0.9	-0.0
Ulcerative Colitis	0.2	0.3	0.9	0.9	-0.1
Heel T-Score	0.2	1.7	2.6	-1.6	1.6
Systolic Blood Pressure	0.2	1.0	1.8	-1.3	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	0.1	-1.0
Tanning	0.2	2.2	5.2	-1.2	2.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.0	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.0	0.9
Pack years adult smoking proportion	0.2	0.4	1.0	0.3	-1.0
Average weekly fortified wine intake	0.2	0.2	0.6	-0.8	0.2
Maternal smoking around birth	0.2	0.3	0.7	-0.4	-0.8
Fed-up feelings	0.2	0.3	0.7	0.9	0.3
Taking other prescription medications	0.2	0.4	0.8	0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	-0.7	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	-0.7	0.9
Nervous feelings	0.2	0.3	0.7	0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-0.7	1.0
Qualifications: None of the above	0.2	0.5	1.3	1.1	-0.3
Heart attack	0.2	0.3	0.5	0.7	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.7	0.6
Fluid intelligence score	0.2	0.3	1.0	-1.0	0.1
Impedance of arm (right)	0.2	1.1	3.1	1.8	0.2
Hip circumference	0.2	0.8	2.1	-0.5	-1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.0	1.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.7	0.5
Medication: Lansoprazole	0.2	0.3	0.8	-0.9	0.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	-0.9	0.2
Trunk predicted mass	0.2	1.4	2.8	-1.2	-1.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.2	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	-0.0	0.9
Comparative body size at age 10	0.2	0.7	1.2	1.1	0.9
Number of full brothers	0.2	0.3	0.6	0.8	0.5
Qualifications: College or University degree	0.2	0.5	1.3	-1.1	0.4
Pulse rate, automated reading	0.2	0.8	2.2	-0.4	-1.5
Suffer from ‘nerves’	0.2	0.3	0.9	0.3	-0.9
Chest pain or discomfort	0.2	0.2	0.5	0.4	0.7
Family relationship satisfaction	0.2	0.2	0.5	0.7	0.5
Asthma (self-reported)	0.2	0.3	0.7	0.8	-0.5
Osteoporosis (self-reported)	0.2	0.3	0.9	0.9	-0.0
Medication: Gliclazide	0.2	0.2	0.4	0.6	-0.4
Guilty feelings	0.2	0.2	0.7	-0.0	0.9
Financial situation satisfaction	0.2	0.3	0.8	0.9	0.0
Medication: Blood pressure	0.2	0.3	0.9	0.2	-1.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.8	-0.2
Alcohol drinker status: Never	0.2	0.3	0.5	0.5	0.7
Ever smoked	0.2	0.3	0.5	-0.7	-0.6
Arm fat-free mass (left)	0.2	1.2	2.2	-1.2	-1.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.6	0.5
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.8	0.5
Alcohol drinker status: Previous	0.2	0.2	0.6	0.1	-0.8
Arm predicted mass (left)	0.2	1.2	2.3	-1.2	-1.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.5	-0.8
Ulcerative Colitis (UC)	0.1	0.3	0.8	0.9	-0.0
Reaction Time	0.1	0.1	0.3	0.6	-0.0
Prostate Cancer	0.1	0.1	0.4	-0.6	-0.2
HDL Cholesterol	0.1	0.2	0.6	0.8	-0.3
Blood Eosinophil Count	0.1	0.9	2.3	-0.5	1.5
Height	0.1	1.4	2.7	1.6	-1.2
Smoking Status	0.1	0.3	0.5	0.7	-0.7
Lung FEV1/FVC ratio	0.1	0.3	0.7	0.8	-0.3
Neuroticism	0.1	0.4	0.8	0.9	0.5
Hair Pigment	0.1	4.0	11.8	0.6	-3.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	0.5
Angina	0.1	0.2	0.5	0.3	-0.7
Vitamin and mineral supplements	0.1	0.2	0.3	0.5	-0.5
Supplements: Zinc	0.1	0.1	0.2	0.4	0.4
Diabetes (father)	0.1	0.2	0.4	-0.3	0.6
Age when periods started (menarche)	0.1	0.3	0.5	-0.7	-0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.7	0.2
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.7	0.2
Had menopause	0.1	0.1	0.3	-0.5	0.1
Medication: Simvastatin	0.1	0.2	0.5	0.7	-0.0
Time employed in main current job	0.1	0.1	0.2	-0.4	0.4
Falls in the last year	0.1	0.1	0.2	-0.4	-0.4
Number of live births	0.1	0.2	0.3	0.4	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.2	0.5	-0.1
Depression (self-reported)	0.1	0.1	0.3	-0.1	-0.5
Standing height	0.1	0.5	1.4	1.2	-0.3
Breastfed as a baby	0.1	0.1	0.2	-0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	-0.6
Gout (self-reported)	0.1	0.1	0.2	0.5	-0.0
Arm fat-free mass (right)	0.1	0.6	1.4	-0.7	-1.2
Worry too long after embarrassment	0.1	0.1	0.3	-0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.6
Angina (self-reported)	0.1	0.1	0.2	0.4	-0.4
Arm predicted mass (right)	0.1	0.4	1.0	-0.5	-1.0
Had major operations	0.1	0.1	0.2	0.5	-0.3
Smoking status: Previous	0.1	0.1	0.4	-0.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	0.1	-0.6
Friendships satisfaction	0.1	0.1	0.2	0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.5	-0.3
Miserableness	0.1	0.1	0.4	-0.1	-0.6
Irritability	0.1	0.3	0.7	0.2	-0.8
Ever depressed for a whole week	0.1	0.1	0.3	0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.6	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.4	-0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	0.4	-0.1
Neuroticism (Nagel 2018)	0.0	0.1	0.3	0.5	0.2
Crohns Disease (2012)	0.0	0.0	0.1	0.3	-0.1
Blood Platelet Count	0.0	0.2	0.6	-0.8	0.3
Blood White Count	0.0	0.0	0.1	0.3	-0.2
Waist Hip Ratio (WHR)	0.0	0.1	0.1	0.3	0.3
Allergy or Eczema	0.0	0.0	0.1	0.1	0.3
Cardiovascular Disease	0.0	0.0	0.0	0.1	-0.0
Hand grip strength (left)	0.0	0.0	0.1	0.3	0.2
Average weekly spirits intake	0.0	0.0	0.0	-0.1	0.1
Medication: Co-codamol	0.0	0.0	0.1	-0.2	0.1
Diabetes (mother)	0.0	0.0	0.1	-0.2	0.0
Hand grip strength (right)	0.0	0.0	0.0	0.1	0.0
Relative age voice broke	0.0	0.0	0.0	-0.1	-0.0
High blood pressure	0.0	0.1	0.2	0.4	-0.4
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.1	0.3
Sitting height	0.0	0.3	0.8	0.9	0.0
High blood pressure (mother)	0.0	0.0	0.1	0.2	0.2
Past tobacco smoking	0.0	0.0	0.1	0.3	0.2
Allergy	0.0	0.0	0.0	0.1	-0.1
Medication: Ramipril	0.0	0.0	0.0	0.1	0.1
Father’s age at death	0.0	0.0	0.0	0.1	0.2
Prospective memory result	0.0	0.1	0.2	-0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.2	0.1
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	-0.2
Headache pain in last month	0.0	0.1	0.2	-0.4	-0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	0.2
Mean time to correctly identify matches	0.0	0.1	0.1	0.3	-0.4
Comparative height size at age 10	0.0	0.3	0.7	0.9	-0.1
Hypertension (Self-reported)	0.0	0.1	0.2	0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.3	-0.0
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.0	-0.1
Back pain experienced in last month	0.0	0.1	0.2	-0.2	-0.4
Wears glasses or contact lenses	0.0	0.0	0.0	-0.2	0.2
Medication: Bendroflumethiazide	0.0	0.1	0.2	-0.1	0.4
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	-0.2	0.3
Cholesterol lowering medication	0.0	0.0	0.1	-0.3	-0.2

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