Hub : Genes

POLB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.5490 0.0570 0.0e+00 0.380 NA 0.471 NA 0.435 9.3e-27 NA 6.2e-35 NA 1.5e-31
2 GTEx Muscle Skeletal 0.0755 0.0291 3.8e-04 0.030 NA 0.065 NA 0.061 6.1e-04 NA 5.9e-07 NA 1.3e-06
3 GTEx Skin Not Sun Exposed Suprapubic 0.3750 0.0630 3.4e-15 0.283 NA 0.233 NA 0.285 7.3e-16 NA 5.2e-13 NA 5.9e-16
4 GTEx Skin Sun Exposed Lower leg 0.4550 0.0610 0.0e+00 0.376 NA 0.383 NA 0.404 1.2e-32 NA 1.8e-33 NA 1.2e-35
5 GTEx Testis 0.2210 0.0720 1.0e-04 0.006 NA 0.025 NA 0.029 1.6e-01 NA 2.6e-02 NA 2.0e-02
6 METSIM Adipose 0.0296 0.0150 5.7e-03 0.006 0.013 0.012 0.015 0.011 4.0e-02 3.9e-03 5.6e-03 2.3e-03 6.3e-03
7 NTR Blood 0.0108 0.0060 1.7e-02 -0.001 0.003 0.000 0.003 -0.001 5.8e-01 3.1e-02 4.0e-01 3.4e-02 8.4e-01
8 YFS Blood 0.0287 0.0106 1.7e-07 0.028 0.016 0.016 0.019 0.022 1.2e-09 2.9e-06 5.1e-06 5.9e-07 5.7e-08
9 TCGA Bladder Urothelial Carcinoma 0.1070 0.0720 1.6e-06 0.091 0.071 0.065 NA 0.087 4.3e-08 1.3e-06 3.3e-06 NA 7.6e-08
10 TCGA Head and Neck Squamous Cell Carcinoma 0.0943 0.0465 1.0e-06 0.044 0.051 0.048 NA 0.046 1.1e-05 2.2e-06 3.8e-06 NA 5.7e-06
11 TCGA Lung Adenocarcinoma 0.0384 0.0210 1.3e-04 0.043 0.032 0.031 NA 0.032 7.6e-06 1.0e-04 1.2e-04 NA 1.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.7 1.0 5.7 0.1 1.4 -0.5 -0.7 -0.8 2.4 0.7 0.2 0.0 1.2 -0.8
Bipolar Disorder or Schizophrenia 1.0 2.4 9.7 -1.1 2.7 -1.4 -1.4 -0.7 3.1 0.5 1.2 -1.0 -0.6 1.1
Depressed Affect (Nagel 2018) 0.2 0.5 2.0 0.1 -0.2 0.6 0.5 1.2 -1.4 -0.8 -0.5 0.3 -0.1 -0.2
Depression (Nagel 2018) 0.7 1.0 2.2 0.9 -0.8 0.9 1.1 -0.2 -0.7 -1.1 -1.1 1.0 1.5 -1.2
Intelligence (Savage-Jansen 2018) 0.7 2.0 5.9 -0.9 1.5 -1.3 -1.4 -2.4 1.6 1.6 1.4 -1.5 -0.2 0.5
Neuroticism (Nagel 2018) 0.1 0.3 1.1 0.2 0.1 0.1 0.3 1.1 -0.9 -0.9 -0.1 0.0 -0.3 -0.0
Schizophrenia (2018) 1.1 2.3 5.1 -1.5 2.3 -1.4 -1.2 -0.3 2.1 0.1 1.3 -1.4 -1.7 2.0
Schizophrenia vs Biploar Disorder 0.5 0.7 3.2 0.1 -0.5 0.6 0.4 1.8 -0.8 -0.6 -0.2 -0.2 -1.3 1.0
Worry (Nagel 2018) 0.3 0.5 2.5 -0.3 0.3 -0.3 -0.1 1.2 -0.3 -0.1 0.3 -0.5 -1.6 1.2
Alzheimer’s Disease (in mother) 1.2 1.4 3.5 -1.4 -0.0 -1.1 -1.6 -1.0 1.9 1.3 1.2 -0.9 -0.5 0.8
Alzheimer’s Disease (in father) 0.9 0.9 4.3 0.2 1.1 -1.0 -0.2 -2.1 0.1 -1.3 -0.2 0.3 0.7 -1.2
Alzheimer’s Disease (including proxy) 0.9 1.3 4.4 -0.9 0.5 -1.5 -1.3 -1.9 2.1 0.5 0.9 -0.5 -0.1 -0.1
Crohns Disease (2017) 1.3 2.8 7.8 0.9 -1.4 1.9 1.6 1.5 -2.3 -2.8 -1.8 1.5 0.4 -1.0
Irritable Bowel Disease (IBD) 0.8 1.9 4.5 0.9 -0.3 1.4 1.3 1.7 -2.0 -2.1 -1.5 1.2 -0.7 -0.7
Ulcerative Colitis (UC) 0.4 0.7 3.2 0.3 0.2 0.7 0.7 1.8 -1.0 -0.6 -0.6 0.6 -1.3 -0.1
Major Depression (MDD) 1.4 1.7 5.1 0.0 -1.2 1.2 1.4 1.8 -1.4 -2.3 -1.4 1.1 -0.2 -0.3
Reaction Time 0.3 0.5 1.1 0.4 -0.8 0.4 0.8 1.0 -1.1 -0.6 -0.9 0.7 -0.6 -0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 5.9 0.6 0.4 -0.4 0.1 -2.4 0.2 -0.1 -0.1 0.1 1.0 -0.6
Breast Cancer 0.1 0.3 0.9 0.1 -0.8 0.4 0.1 0.6 -0.3 0.1 -0.1 -0.4 -0.8 0.9
Ovarian Cancer 0.6 0.9 4.0 -0.8 -0.6 -0.1 -0.7 0.6 1.1 2.0 0.7 -1.1 -0.1 0.9
Prostate Cancer 0.4 0.5 2.7 0.2 0.2 -0.2 -0.8 -1.0 0.8 1.6 0.5 0.0 0.2 -0.3
Age at First Birth 0.6 0.8 2.5 -0.4 0.3 -0.5 -0.8 1.2 1.6 1.4 1.0 -0.8 -0.3 0.6
Bipolar Disorder (2011) 0.9 0.9 3.2 0.5 1.0 -0.4 -0.2 -1.6 1.8 -0.2 0.2 0.2 1.2 -1.1
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 0.6 -1.3 0.8 1.2 -0.6 -0.2 -0.9 -0.8 1.1 1.1 -0.8
Coronary Artery Disease (CAD) 2.3 2.8 4.6 1.2 -0.6 2.0 1.9 0.7 -2.1 -1.6 -1.9 1.9 1.4 -2.0
Crohns Disease (2012) 1.1 1.7 10.3 -0.1 0.2 0.5 0.2 1.3 -2.4 -3.2 -0.8 0.1 -0.2 0.2
Mean Putamen Volume 1.2 1.3 3.5 -1.4 1.9 -0.7 -1.0 0.2 1.0 0.3 1.0 -1.5 -0.9 1.6
Fasting Glucose 1.2 1.4 2.4 -1.0 1.1 -1.5 -1.2 -1.1 0.8 1.5 1.3 -1.1 -1.3 1.1
HbA1C 2.0 2.2 5.1 -1.7 1.6 -1.2 -1.3 1.2 -1.3 -0.7 1.2 -1.4 -2.3 1.9
HDL Cholesterol 0.1 0.1 0.3 -0.5 -0.0 0.3 0.4 0.1 -0.4 0.3 -0.3 0.5 -0.3 -0.0
LDL Cholesterol 0.6 1.0 2.9 -0.8 0.8 -1.7 -1.0 -1.5 0.6 0.6 1.1 -1.1 -0.0 0.4
Lupus 2.2 3.3 7.6 1.1 -1.8 2.0 2.3 2.2 -2.8 -1.0 -2.0 1.8 0.5 -1.5
Neuroticism (2016) 0.8 1.2 4.4 -0.9 -0.1 0.5 0.1 1.6 -0.6 0.8 0.2 -0.6 -2.1 1.8
Primary Biliary Cirrhosis 3.9 5.6 13.5 1.8 -2.1 2.5 2.8 1.9 -3.7 -2.7 -2.4 2.4 0.4 -1.8
Rheumatoid Arthritis 0.1 0.2 0.4 -0.5 -0.6 0.3 0.0 0.6 -0.3 0.1 -0.1 -0.3 -0.4 0.5
Schizophrenia (2014) 1.4 3.1 7.9 -1.6 2.8 -1.9 -1.6 -1.1 2.5 0.2 1.6 -1.5 -1.3 1.8
Triglycerides 1.2 1.9 2.6 -1.3 1.6 -1.4 -1.4 -0.8 0.9 1.4 1.5 -1.6 -1.5 1.5
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.7 -0.8 0.4 0.2 0.3 0.5 -1.5 -1.6 -0.4 0.3 -0.7 0.2
Ulcerative Colitis 0.2 0.3 0.9 -0.4 0.9 0.6 0.5 0.5 -0.2 -1.0 -0.3 0.5 -0.7 -0.1
Blood Eosinophil Count 0.4 3.3 13.5 -1.1 3.7 -2.0 -1.4 -1.8 -0.9 -0.5 1.4 -1.8 -1.8 1.9
Blood Platelet Count 0.1 1.7 6.5 -1.4 1.3 -1.1 -0.7 -1.7 2.5 1.7 0.2 -0.4 -0.3 0.4
Blood Red Count 1.3 12.9 69.6 1.9 2.0 -0.8 -0.6 -3.2 8.3 6.0 0.6 0.2 3.1 -2.5
Blood White Count 0.2 1.1 7.2 -0.2 1.7 0.2 0.2 0.4 1.2 2.7 -0.3 0.5 -0.5 -0.3
Heel T-Score 0.6 4.7 8.6 -2.4 2.5 -2.9 -2.5 -2.8 2.5 -1.0 2.1 -1.7 0.1 1.3
BMI 0.5 2.7 6.4 2.0 -2.0 1.9 2.0 0.3 -0.5 -1.1 -0.9 1.4 2.5 -1.7
Height 0.3 5.7 15.3 2.2 -2.5 3.2 2.6 3.9 -3.0 -1.4 -1.8 1.7 1.1 -0.9
Waist Hip Ratio (WHR) 0.1 0.4 3.6 -0.5 0.2 0.4 -0.1 1.9 0.7 -0.1 0.3 -0.1 0.3 0.3
Systolic Blood Pressure 0.3 1.3 3.2 0.1 0.9 -1.6 -1.1 -1.8 -1.2 -0.4 1.0 -1.1 -1.5 1.0
Smoking Status 0.2 0.5 1.3 0.2 0.6 1.0 0.8 -0.4 -1.1 -0.5 -1.0 0.6 -0.3 -0.3
Allergy or Eczema 0.1 0.2 0.9 -0.1 -0.0 -0.2 0.2 1.0 -0.6 0.7 -0.1 -0.4 -0.1 0.3
Cardiovascular Disease 0.2 0.5 3.0 0.4 0.1 0.2 0.4 -0.7 -1.2 -1.7 -0.3 0.1 -0.1 0.4
Hypothyroidism (self reported) 0.5 1.1 3.1 -1.2 -0.1 -1.3 -1.1 0.5 -0.9 -0.3 0.8 -1.0 -1.8 1.3
Respiratory disease 0.8 1.8 3.3 0.8 -1.5 1.7 1.8 1.0 -1.4 -1.2 -1.6 1.5 1.0 -1.0
Type 2 Diabetes (T2D) (2018) 0.9 1.7 5.2 0.8 -0.8 1.2 1.3 0.8 -1.7 -2.3 -1.2 1.1 1.3 -1.0
Lung FEV1/FVC ratio 0.0 0.2 0.8 0.5 0.2 0.9 0.1 0.8 0.2 0.1 -0.3 -0.4 0.4 -0.0
Lung FVC 0.2 1.3 4.7 -1.4 0.9 -1.0 -0.9 -0.6 -0.5 -0.1 0.7 -1.0 -2.2 1.7
Neuroticism 0.1 0.1 0.8 0.0 -0.3 -0.1 0.0 0.9 -0.4 -0.4 0.1 -0.2 -0.4 0.5
Chronotype (morning person) 0.5 1.1 2.4 -1.3 1.5 -0.8 -0.4 -0.6 -0.7 -1.1 0.9 -0.8 -1.5 1.2
Hair Pigment 0.3 9.4 20.5 2.9 -2.9 4.4 4.5 2.2 -1.2 -1.6 -3.7 3.4 2.3 -2.7
Tanning 0.5 6.3 13.3 -3.2 2.5 -3.5 -3.6 -1.9 2.3 1.1 2.7 -2.3 -1.5 1.4
Hand grip strength (left) 0.1 0.2 1.6 0.1 0.3 0.3 -0.0 0.7 -1.3 -0.2 -0.0 -0.1 0.0 0.2
Number of treatments/medications taken 0.6 1.0 4.7 -1.0 -0.8 0.9 0.9 2.2 -0.8 -1.2 -0.4 0.0 -0.8 0.8
Average weekly spirits intake 0.1 0.2 0.9 0.1 0.2 -0.0 0.2 -0.5 -0.7 -1.0 0.1 0.1 0.0 0.2
Sensitivity / hurt feelings 0.4 0.8 5.0 0.1 0.5 0.8 0.7 2.2 -0.9 -0.9 -0.4 0.4 0.1 -0.2
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.9 0.5 -1.2 1.2 1.1 0.5 -0.8 -0.4 -1.1 1.0 1.4 -1.0
Hearing difficulty/problems: Yes 1.2 1.8 8.4 -1.1 1.3 -0.9 -1.4 0.2 2.9 1.5 1.4 -1.1 -0.2 0.6
Relative age of first facial hair 0.6 1.3 3.0 1.2 -1.2 1.3 1.7 -0.1 -1.0 0.1 -1.6 1.5 0.6 -0.7
Other serious medical condition/disability diagnosed by doctor 4.0 5.2 10.7 1.5 -2.7 1.8 2.5 0.4 -3.3 -3.1 -2.5 2.2 1.8 -2.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 -0.5 0.9 -0.3 -0.7 -0.1 0.8 1.1 0.9 -0.7 -0.0 0.6
Ever had hysterectomy (womb removed) 0.7 0.8 3.6 0.4 -1.1 1.9 1.1 0.6 0.9 -0.4 -0.9 0.7 0.7 -0.0
Systolic blood pressure, automated reading 0.4 1.1 3.9 -0.1 1.1 -1.3 -0.9 -2.0 -0.1 -1.4 1.1 -1.0 -0.4 0.6
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.1 0.5 0.4 -0.2 0.1 0.7 -0.1 -0.7 -0.0 0.4 1.0 -0.5
Angina 0.4 0.6 1.5 0.1 0.4 1.0 1.0 1.2 -0.7 0.1 -0.7 0.8 0.7 -0.7
Medication for hormone replacement therapy 1.0 1.1 3.1 -1.4 0.0 -0.2 -0.5 0.5 -1.6 -0.0 1.0 -1.0 -1.4 1.8
Vitamin and mineral supplements 0.1 0.2 0.6 -0.1 0.6 0.4 0.1 -0.4 -0.1 0.7 -0.2 0.3 0.6 -0.3
Supplements: Zinc 0.2 0.3 0.7 -0.2 0.4 -0.5 -0.7 -0.5 0.8 -0.8 0.4 -0.4 0.0 0.0
Medication: Co-codamol 0.2 0.3 2.5 -0.5 0.0 -0.2 0.0 0.0 -0.2 -1.6 0.3 -0.0 0.4 0.0
Medication: Metformin 1.6 2.2 7.6 1.0 -0.8 1.4 1.7 1.5 -1.8 -2.8 -1.4 1.3 1.0 -0.8
Diabetes (father) 0.5 0.6 1.7 -0.6 1.3 -1.0 -0.4 -0.7 0.6 0.9 0.3 -0.3 -1.1 0.6
Diabetes (mother) 0.5 0.7 2.9 0.1 -0.5 0.4 0.6 1.4 -1.2 -1.7 -0.2 -0.1 0.3 0.1
Severe depression (siblings) 2.0 2.3 3.8 1.9 -1.9 1.4 1.7 0.2 -0.2 -1.8 -1.4 1.5 1.7 -1.6
Pack years adult smoking proportion 1.1 1.7 3.2 1.6 -0.5 1.6 1.7 0.7 -1.3 -1.8 -1.3 1.4 0.8 -0.8
Impedance of leg (right) 0.4 1.9 4.3 -1.4 1.6 -1.0 -1.0 1.4 -2.1 -0.1 0.3 -0.9 -2.0 1.7
Leg fat-free mass (left) 0.9 4.5 9.4 2.7 -2.8 3.1 2.7 1.7 -0.9 -0.9 -1.4 1.8 2.4 -1.8
Trunk fat percentage 2.1 8.5 18.1 2.0 -2.3 4.0 3.9 4.3 -3.1 -1.2 -2.6 2.5 2.4 -2.1
Hand grip strength (right) 0.1 0.2 2.1 0.4 0.0 0.5 0.2 0.1 -1.4 -0.2 -0.0 -0.1 0.3 0.2
Townsend deprivation index at recruitment 0.2 0.2 0.7 -0.6 0.3 0.6 0.0 0.9 -0.3 -0.0 0.1 -0.1 -0.8 0.7
Current tobacco smoking 0.7 1.2 2.8 0.9 -0.8 1.7 1.6 0.6 -1.2 -0.9 -1.6 1.1 0.0 -0.3
Average weekly fortified wine intake 0.2 0.2 0.5 0.2 -0.5 -0.7 -0.4 -0.7 0.3 -0.4 0.0 -0.1 -0.5 -0.0
Maternal smoking around birth 1.3 1.8 9.2 0.6 0.3 0.9 1.4 1.1 -1.7 -3.0 -1.1 0.8 1.0 -0.8
Fed-up feelings 0.4 0.7 4.0 -0.1 -0.7 0.7 0.3 2.0 -1.3 -0.9 -0.4 0.2 0.0 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.9 0.6 -0.5 0.3 0.6 -0.7 -0.6 -0.2 -0.6 0.8 1.4 -0.9
Relative age voice broke 0.1 0.1 0.5 -0.4 0.2 0.1 -0.1 -0.3 0.5 0.7 -0.1 -0.0 0.2 0.1
Taking other prescription medications 0.8 1.2 2.6 0.2 -1.3 1.3 1.3 1.6 0.1 -1.5 -1.2 0.7 1.2 -0.7
Age when periods started (menarche) 0.1 0.4 2.4 0.5 -0.3 -0.2 -0.4 0.3 1.6 0.3 -0.3 0.4 0.1 -0.8
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 4.2 1.3 -1.5 2.1 1.3 1.6 1.2 0.3 -1.1 1.3 1.4 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.1 -0.7 1.2 -1.0 -1.1 -0.6 0.6 -0.5 1.4 -0.6 -0.1 0.7
Tinnitus: Yes, but not now, but have in the past 3.4 3.6 6.2 2.2 -2.5 2.0 1.8 -0.7 -1.1 -1.3 -2.2 2.3 1.9 -2.0
Qualifications: CSEs or equivalent 0.0 0.1 0.2 -0.1 0.1 0.2 0.0 0.4 -0.4 0.4 0.0 0.1 0.0 -0.0
Serious illness, injury or assault to yourself 0.2 0.3 1.9 -0.2 -0.7 0.0 0.1 -0.0 -0.6 -1.4 0.1 -0.0 -0.4 0.4
High blood pressure 0.2 0.4 1.6 0.3 -0.0 0.6 1.0 -0.3 -0.9 -1.3 -0.6 0.6 0.2 -0.0
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.4 -0.3 0.1 -1.1 -0.8 0.6 -0.2 0.8 0.8 -1.2 -0.2 0.8
Multivitamins +/- minerals 0.1 0.1 0.5 0.0 -0.3 -0.4 -0.4 0.2 0.7 -0.2 0.1 -0.2 0.2 -0.1
Stomach or abdominal pain in last month 0.2 0.2 1.0 -0.2 0.3 0.0 0.3 0.8 -0.3 -1.0 -0.2 -0.3 0.7 0.2
Supplements: Glucosamine 1.3 1.6 3.3 0.7 -1.2 1.6 1.5 1.5 -1.0 -1.1 -1.2 1.8 0.5 -1.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.6 -0.4 1.4 -1.4 -1.5 -1.6 0.8 0.1 1.2 -0.9 -0.3 1.0
Medication: Atenolol 1.3 1.6 2.9 -1.7 1.3 -1.6 -1.5 -1.0 -0.0 0.1 1.4 -1.4 -1.3 1.4
Medication: Levothyroxine sodium 0.6 1.0 2.5 -1.6 1.3 -1.1 -1.0 0.1 -0.1 1.1 0.6 -0.8 -1.1 1.0
Sitting height 0.2 1.3 5.4 0.9 -0.6 1.5 1.1 1.8 -2.3 -0.6 -0.5 0.5 -0.1 0.2
Chronic bronchitis/emphysema (father) 0.2 0.2 0.8 -0.4 -0.1 -0.6 -0.2 -0.5 0.2 -0.5 0.3 -0.1 0.9 -0.5
High blood pressure (mother) 0.2 0.2 0.9 -0.1 -0.6 -0.1 -0.0 0.2 1.0 -0.9 0.0 -0.3 0.4 -0.1
Body mass index (BMI) 1.2 5.1 10.2 2.5 -2.4 3.0 3.0 1.3 -0.6 -1.0 -1.5 2.2 3.2 -2.5
Impedance of leg (left) 0.5 2.6 5.3 -1.9 1.8 -1.5 -1.3 1.6 -2.2 0.0 0.5 -1.1 -2.3 1.8
Leg predicted mass (left) 0.9 4.5 9.5 2.6 -2.8 3.1 2.7 1.8 -0.8 -0.9 -1.4 1.8 2.4 -1.8
Trunk fat mass 2.1 9.2 17.5 2.6 -2.6 4.2 4.0 4.1 -2.9 -1.2 -2.5 2.7 2.9 -2.4
Waist circumference 1.3 4.7 9.2 1.9 -2.1 3.0 2.7 2.8 -0.5 -0.8 -1.4 1.9 2.9 -2.0
Number of incorrect matches in round 1.1 1.9 7.0 1.4 -0.9 0.5 1.1 -0.1 -0.3 -2.6 -1.1 1.4 1.7 -1.9
Past tobacco smoking 0.2 0.3 1.3 -0.1 -1.1 0.1 0.6 0.9 0.4 -0.6 0.1 0.1 0.3 0.3
Alcohol usually taken with meals 2.0 3.3 11.6 1.2 -1.6 0.6 0.6 -0.8 2.6 1.4 -1.0 1.1 3.4 -2.9
Nervous feelings 0.6 1.2 2.8 0.9 -1.1 1.2 1.4 1.7 -1.2 0.0 -1.3 1.1 0.2 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 4.0 -0.0 -0.7 0.8 0.7 1.3 -2.0 -0.4 -0.7 0.5 -0.5 0.1
Hearing difficulty/problems with background noise 0.9 1.4 4.5 -2.1 1.1 -1.0 -1.2 0.2 1.3 0.1 1.1 -1.4 -1.0 1.1
Hair/balding pattern: Pattern 2 2.8 3.6 6.1 -2.0 2.1 -2.5 -2.3 -1.7 1.4 0.2 2.1 -2.1 -1.9 1.7
Had menopause 0.4 0.5 2.8 -0.2 0.8 -0.3 -0.6 -0.6 1.7 0.3 0.7 -0.7 0.6 0.3
Had other major operations 6.7 8.2 16.3 3.0 -2.6 2.8 3.2 1.0 -2.1 -4.0 -3.3 3.3 2.2 -2.7
Forced vital capacity (FVC) 0.2 0.7 2.6 0.5 -0.9 0.2 0.0 0.9 -1.6 0.6 -0.1 -0.2 -1.4 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.9 -1.0 1.4 -1.3 -1.5 -0.9 1.4 -0.2 1.7 -1.0 -0.1 1.0
Ever unenthusiastic/disinterested for a whole week 3.0 3.7 6.2 1.9 -1.6 1.6 2.2 0.7 -0.7 -2.5 -2.1 2.2 2.1 -2.3
Qualifications: None of the above 0.5 1.2 6.0 0.1 -1.1 0.7 0.5 0.3 -1.8 -2.4 -0.1 0.7 -0.8 -0.3
Financial difficulties in last 2 years 0.4 0.6 1.6 0.3 -0.6 0.8 0.7 1.2 -1.1 -0.6 -0.9 0.7 0.5 -0.3
Mouth/teeth dental problems 0.5 0.7 5.6 0.7 0.5 -0.9 -0.2 -2.4 0.4 -0.1 -0.1 -0.0 -0.2 -0.6
Heart attack 0.5 0.6 2.3 -1.5 0.8 -0.1 -0.1 1.4 -0.7 -1.1 0.3 -0.4 -0.1 0.4
Allergy 0.2 0.4 2.0 -0.1 1.2 -0.0 -0.2 -1.4 0.6 0.3 0.2 0.2 -0.4 -0.2
Pain all over the body in last month 1.8 1.9 4.3 1.9 -2.1 1.5 1.2 0.6 -0.9 -0.5 -1.3 1.3 1.7 -1.4
Diabetes (self-reported) 1.3 2.0 4.2 0.7 -1.1 1.3 1.6 1.6 -1.7 -2.1 -1.3 1.4 1.3 -1.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.9 0.1 0.1 0.2 -0.1 1.3 -0.7 1.7 0.0 -0.6 -0.5 0.7
Medication: Ramipril 0.1 0.1 0.3 0.3 0.1 -0.3 -0.2 0.4 -0.5 -0.3 0.1 -0.1 -0.1 0.0
Medication: Simvastatin 0.2 0.3 1.0 -0.5 -0.3 0.0 0.1 -1.0 1.0 -0.5 0.1 -0.3 -0.4 0.7
Fluid intelligence score 0.3 0.6 1.8 -0.0 0.1 -0.6 -0.5 -1.4 1.2 1.3 0.6 -0.6 0.3 0.3
Illnesses of siblings 0.9 1.3 3.4 -0.1 1.8 -1.3 -1.3 -1.8 0.6 0.7 1.3 -0.8 -0.6 0.7
Neuroticism score 0.2 0.4 2.9 -0.1 0.2 0.2 0.1 1.7 -0.8 -0.2 -0.3 0.1 -0.4 0.3
Weight 1.4 6.7 13.1 2.8 -2.8 3.6 3.3 2.6 -1.6 -0.9 -1.7 2.3 3.2 -2.2
Impedance of arm (right) 0.4 2.1 10.7 -0.7 -0.2 0.8 0.8 3.3 -2.6 -0.3 -1.7 0.5 -0.4 -0.1
Arm fat percentage (right) 2.2 8.6 15.1 2.5 -2.9 3.9 3.8 3.1 -1.9 -1.1 -2.6 2.8 3.6 -2.9
Trunk fat-free mass 0.4 2.3 6.1 2.5 -2.0 1.9 1.5 0.3 0.1 -0.7 -0.5 1.3 2.2 -1.4
Hip circumference 0.7 2.9 5.7 1.9 -1.6 2.4 2.3 2.1 -0.9 -0.2 -0.9 1.3 2.2 -1.4
Time employed in main current job 0.2 0.2 1.4 0.2 0.3 -0.2 -0.1 -0.2 0.3 -1.2 0.0 -0.0 0.8 -0.1
Alcohol intake versus 10 years previously 1.8 2.6 12.4 0.3 -1.1 2.1 1.3 3.5 -2.2 -0.6 -1.6 0.9 0.0 -0.5
Father’s age at death 0.1 0.2 0.4 -0.2 0.4 0.2 0.3 0.6 -0.2 -0.2 -0.6 0.3 0.6 -0.1
Worrier / anxious feelings 0.2 0.4 3.3 0.0 0.0 0.7 0.4 1.8 0.2 0.1 -0.1 0.1 -0.3 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 5.0 0.2 -1.1 1.4 0.9 2.2 -0.7 1.3 -0.8 0.7 0.6 -0.5
Falls in the last year 0.2 0.3 0.8 -0.3 -0.6 0.3 0.3 0.9 -0.8 0.4 -0.4 0.5 0.6 -0.6
Hair/balding pattern: Pattern 3 2.0 3.1 5.3 2.1 -1.3 2.0 1.8 0.8 -0.2 -1.2 -2.0 2.3 2.1 -2.2
Number of live births 0.4 0.5 1.1 0.4 -0.9 0.9 0.9 1.0 -0.4 -0.5 -1.0 0.7 0.6 -0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.3 0.6 -0.9 0.3 0.0 0.9 -1.5 0.2 -0.2 -0.1 -1.1 0.9
Pulse rate 1.3 2.2 6.4 1.5 -0.8 1.8 1.7 0.8 0.7 -0.4 -1.0 1.8 2.5 -1.9
Happiness 0.5 0.6 1.7 0.3 0.1 1.2 0.6 -0.5 1.0 0.0 -0.9 0.5 1.3 -0.7
Noisy workplace 0.8 1.0 4.0 -0.4 0.0 0.6 0.4 1.1 -1.3 -2.0 -0.0 -0.0 -1.6 0.9
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.6 0.5 -0.7 -0.9 -1.0 -0.9 1.6 1.4 0.4 -0.1 1.6 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 3.8 -0.2 -0.1 0.2 0.4 2.0 -1.4 -0.8 -0.5 -0.3 -0.4 0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 4.0 -0.6 -1.1 0.9 0.9 1.2 -2.0 -1.0 -0.5 0.6 -0.4 0.3
Asthma 0.5 0.9 1.9 0.3 -1.4 1.3 1.1 1.2 -0.9 -1.2 -1.0 0.7 0.5 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 4.4 -0.7 0.3 0.3 0.1 0.9 -0.0 -2.1 0.0 -0.0 -0.6 0.6
Medication: Cholesterol lowering 0.0 0.1 0.2 -0.4 0.3 0.3 0.3 0.2 -0.4 -0.0 -0.1 0.0 0.1 0.4
Depression (self-reported) 0.1 0.1 0.5 -0.4 0.3 0.1 0.3 -0.6 0.7 -0.0 -0.0 -0.1 0.2 -0.3
Medication: Lansoprazole 0.5 0.6 1.9 -1.0 0.6 -0.9 -0.7 -1.4 0.8 0.4 0.9 -0.2 0.1 -0.3
Prospective memory result 0.1 0.1 0.8 0.4 -0.1 -0.1 -0.3 -0.5 0.9 0.1 0.3 0.1 0.4 0.1
Lung cancer (father) 1.6 1.9 4.0 -1.8 0.1 -2.0 -1.7 -1.0 -0.4 -0.6 1.6 -1.4 -1.7 1.1
Illnesses of mother 0.5 0.6 5.0 -0.2 0.1 0.9 -0.1 0.6 -0.3 2.2 0.1 -0.0 -0.7 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 5.5 1.1 -1.5 1.3 1.1 1.8 -2.3 -0.2 -1.0 0.5 -0.9 0.7
Pulse wave Arterial Stiffness index 0.8 0.9 4.7 -0.4 2.2 -0.4 -0.6 -0.8 1.4 0.6 1.1 -0.5 0.0 -0.2
Impedance of arm (left) 0.5 2.3 11.9 -1.0 -0.1 0.9 0.8 3.5 -2.7 0.4 -1.5 0.3 -0.9 0.6
Arm fat mass (right) 2.0 8.1 14.4 2.7 -3.0 3.8 3.7 2.8 -1.9 -1.1 -2.3 2.7 3.5 -2.8
Trunk predicted mass 0.4 2.2 6.0 2.5 -1.9 1.9 1.5 0.3 0.2 -0.7 -0.5 1.3 2.2 -1.3
Standing height 0.2 2.3 9.8 1.2 -1.2 2.0 1.4 3.1 -2.3 -0.2 -0.9 0.7 0.6 -0.0
Length of working week for main job 0.5 0.6 2.1 0.6 -0.3 -0.2 -0.1 -1.3 0.9 -0.5 0.1 0.2 1.4 -0.9
Exposure to tobacco smoke at home 1.8 2.0 3.9 0.9 -1.4 1.5 1.7 1.0 -1.8 -0.9 -1.9 2.0 0.5 -1.4
Breastfed as a baby 0.2 0.2 0.9 -0.4 -0.2 -0.2 -0.3 -0.1 0.7 1.0 0.2 0.1 0.5 -0.6
Tense / ‘highly strung’ 0.2 0.3 1.1 -0.3 -0.9 0.0 -0.1 1.1 -0.2 0.3 -0.2 -0.3 -0.6 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.2 0.7 -1.1 0.7 0.9 1.0 -0.7 -0.7 -0.4 0.7 0.2 -0.5
Hair/balding pattern: Pattern 4 0.8 1.9 3.5 1.0 -1.2 1.8 1.8 1.0 -1.9 -0.4 -1.5 1.4 1.0 -1.1
Birth weight of first child 1.4 2.5 5.5 -2.1 1.0 -1.6 -2.0 0.1 1.0 2.3 1.8 -1.6 -1.0 1.4
Peak expiratory flow (PEF) 0.3 0.6 2.9 0.5 -0.9 0.6 0.4 1.1 -1.7 0.1 -0.4 0.1 -0.7 0.8
Pulse wave reflection index 2.1 2.6 5.5 -1.4 2.3 -1.7 -2.1 -1.6 2.0 1.4 1.7 -1.4 -1.1 0.6
Ever highly irritable/argumentative for 2 days 1.7 2.0 4.0 1.3 -0.8 1.0 1.5 0.5 -1.3 -1.3 -2.0 1.7 1.4 -1.9
Loud music exposure frequency 1.1 1.2 6.2 -0.7 -1.3 0.1 0.5 2.5 -0.9 -1.0 -0.3 -0.4 -1.3 1.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.6 0.4 -1.6 0.6 -0.1 0.9 -0.4 1.5 -0.2 -0.1 0.8 -0.0
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.1 -0.5 1.4 -0.8 -1.1 0.1 1.2 0.5 1.0 -0.9 0.1 0.6
Blood clot in the leg (DVT) 0.3 0.4 1.8 -0.6 -0.6 -0.2 -0.1 -0.5 1.3 -1.3 0.2 0.2 0.2 -0.0
Medication: Paracetamol 1.1 1.8 4.5 0.8 -2.1 1.5 1.5 2.0 -1.7 -0.4 -1.2 1.1 -0.5 -0.5
Headache pain in last month 0.2 0.3 1.2 0.1 -0.3 -0.0 -0.0 1.1 0.4 -0.7 -0.6 0.2 0.6 -0.6
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.5 -0.6 -0.6 -0.4 -0.7 0.5 -0.1 -0.0 -0.0 0.5 -0.5
Glaucoma (self-reported) 1.7 2.0 6.1 -1.4 0.8 -0.3 -0.8 1.4 -1.0 1.0 1.0 -1.5 -2.4 2.5
Gout (self-reported) 0.6 0.8 7.2 -0.2 0.8 0.1 -0.3 0.3 -0.0 2.7 0.1 -0.6 -0.6 0.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.9 -1.4 -0.4 -1.1 -1.2 0.5 0.3 0.9 0.8 -1.1 -1.7 1.5
Medication: Amlodipine 0.5 0.7 1.3 -1.1 0.9 -0.4 -0.6 0.8 0.1 1.0 0.6 -1.0 -1.1 1.0
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.9 -0.9 1.4 -0.9 -0.8 -0.8 0.5 0.3 0.8 -0.7 -1.1 0.9
Birth weight 0.3 0.6 3.2 -0.5 -0.9 0.6 0.1 1.0 0.7 1.8 0.3 -0.1 -0.5 0.5
Chronic bronchitis/emphysema (mother) 1.7 2.0 3.8 -1.2 1.0 -1.9 -1.4 -1.1 -0.1 -0.8 1.8 -1.6 -2.0 1.6
High blood pressure (siblings) 0.5 0.7 3.3 -1.5 -0.3 0.1 -0.1 1.8 0.8 0.0 0.1 -0.9 -0.3 0.7
Forced vital capacity (FVC), Best measure 0.5 1.8 5.6 1.2 -1.8 1.4 1.2 1.9 -2.4 -0.0 -1.1 0.6 -0.8 0.6
Body fat percentage 2.0 7.8 14.7 2.2 -2.4 3.8 3.8 3.7 -2.6 -1.2 -2.4 2.5 2.8 -2.3
Leg fat percentage (right) 1.5 5.6 10.2 2.2 -2.0 3.2 3.2 1.9 -1.8 -1.5 -2.0 2.3 3.0 -2.2
Arm fat-free mass (right) 0.3 1.3 4.1 2.0 -1.4 1.6 1.4 0.4 0.0 -0.6 -0.1 0.8 1.5 -0.8
Exposure to tobacco smoke outside home 2.9 3.9 12.8 1.0 -1.0 1.3 2.0 2.5 -3.6 -3.0 -1.9 1.7 0.2 -0.9
Comparative body size at age 10 0.4 1.1 8.4 0.2 -0.2 -0.3 -0.2 -0.7 -0.5 -2.9 1.0 -0.8 -0.7 1.0
Number of full brothers 0.4 0.6 3.3 -0.4 -0.4 -0.1 0.0 0.4 -1.8 -0.3 -0.2 -0.5 -1.2 0.8
Worry too long after embarrassment 0.2 0.4 2.4 0.2 1.0 -0.3 -0.3 -0.0 1.5 0.4 0.4 -0.1 0.7 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.1 -1.2 0.0 -0.9 -1.1 -1.5 1.8 1.1 1.1 -1.0 -0.3 0.9
Wheeze or whistling in the chest in last year 1.3 2.3 4.8 1.3 0.3 1.1 1.2 1.1 -1.8 -2.0 -1.6 1.4 2.2 -1.8
Number of children fathered 4.8 5.4 8.2 -2.6 2.7 -2.6 -2.9 -1.3 1.9 1.9 2.6 -2.5 -1.8 2.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.9 0.4 -1.1 1.0 0.8 1.4 0.6 0.6 -0.4 0.4 0.7 -0.4
Age at first live birth 0.4 0.7 2.7 -0.1 0.6 -1.4 -1.0 -1.6 0.1 -0.4 0.7 -0.5 -0.1 -0.2
Pulse wave peak to peak time 1.0 1.1 5.4 0.5 -2.3 0.7 0.8 1.2 -1.5 -0.4 -1.2 0.6 0.1 0.3
Health satisfaction 4.5 5.8 10.4 2.4 -2.3 2.3 2.6 1.2 -1.3 -2.7 -2.5 2.5 3.2 -2.7
Shortness of breath walking on level ground 1.5 1.8 2.9 1.2 -1.0 1.3 1.7 0.2 -0.8 -1.7 -1.4 1.4 1.6 -1.5
Qualifications: College or University degree 0.7 2.1 8.4 0.2 0.4 -1.2 -1.2 -1.7 2.9 2.7 0.7 -0.9 -0.0 0.6
Eye problems/disorders: None of the above 1.8 2.1 5.5 1.5 -1.2 0.2 0.3 -2.3 1.5 -0.2 -0.6 1.3 2.1 -2.2
Mouth/teeth dental problems: Loose teeth 1.6 1.9 6.2 -2.0 2.5 -1.3 -1.0 -0.8 -0.5 0.8 1.2 -1.3 -1.1 1.5
Emphysema/chronic bronchitis 0.9 1.1 2.7 1.1 -0.5 1.0 1.4 0.0 -1.1 -1.6 -1.0 0.8 1.0 -0.9
Medication for pain relief, constipation, heartburn 0.5 0.9 3.8 -0.1 0.7 -1.0 -1.2 -1.3 0.6 2.0 0.9 -0.8 0.0 0.2
Neck or shoulder pain in last month 1.7 2.4 4.2 1.6 -1.4 1.7 1.6 0.1 -0.4 -1.1 -1.9 1.7 2.0 -1.9
Medication: Blood pressure 0.5 0.8 2.1 -1.1 1.4 -0.4 -0.3 -0.1 0.0 0.5 0.9 -0.8 -1.4 1.3
Angina (self-reported) 0.3 0.4 1.8 -0.1 0.5 0.8 0.8 1.4 -0.6 0.3 -0.5 0.5 0.5 -0.4
Migraine (self-reported) 0.6 0.7 1.9 0.6 -1.0 -0.3 -0.1 -1.0 0.2 -1.4 -0.5 0.7 1.1 -1.2
Medication: Ibuprofen 0.7 0.9 5.8 -0.3 -0.4 0.7 0.6 1.4 -0.5 -2.4 -0.6 0.3 -0.0 0.3
Medication: Allopurinol 2.4 3.2 11.7 -1.3 1.5 -1.5 -1.7 -1.0 0.9 3.4 1.6 -2.1 -1.5 1.9
Medication: Omeprazole 3.0 3.6 7.3 1.5 -1.9 2.4 2.2 1.0 -0.5 -2.0 -2.0 2.1 2.7 -1.7
Medication: Seretide 50 evohaler 0.3 0.3 1.4 -0.2 -0.2 -0.0 0.2 0.8 -1.1 -1.2 -0.3 0.3 -0.1 -0.3
Mean time to correctly identify matches 0.1 0.3 0.7 0.0 -0.4 0.6 0.6 0.6 -0.0 -0.8 -0.7 0.6 0.1 -0.3
Heart disease (mother) 2.7 3.3 9.2 1.5 -0.7 1.3 2.1 1.0 -1.4 -3.0 -2.0 1.9 2.0 -1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 3.5 0.2 -0.3 0.5 0.9 1.2 -1.9 -0.7 -0.6 0.3 -0.6 0.2
Whole body fat mass 2.1 8.7 16.3 2.7 -2.7 4.0 3.9 3.5 -2.5 -1.2 -2.4 2.7 3.1 -2.5
Leg fat mass (right) 1.7 6.5 12.3 2.5 -2.5 3.5 3.3 2.5 -1.9 -1.6 -1.9 2.3 3.0 -2.2
Arm predicted mass (right) 0.2 1.1 3.3 1.8 -1.2 1.6 1.3 0.4 0.1 -0.6 0.1 0.7 1.3 -0.6
Pulse rate, automated reading 0.5 1.8 3.8 1.2 -0.9 1.7 1.9 0.5 -0.2 -1.3 -1.1 1.8 1.5 -1.3
Alcohol intake frequency. 0.1 0.3 1.3 -0.5 -0.1 0.7 0.5 1.1 0.1 0.5 0.2 -0.0 -0.4 0.5
Comparative height size at age 10 0.4 2.1 6.7 0.5 -1.3 1.3 1.3 2.0 -2.5 -2.6 -0.6 0.7 0.4 -0.2
Number of full sisters 2.3 2.8 6.3 -2.5 1.8 -1.3 -1.3 -1.1 -0.7 0.3 1.3 -2.0 -2.5 2.1
Suffer from ‘nerves’ 0.8 1.2 2.5 0.9 -0.0 0.8 1.2 0.7 -1.2 -1.6 -1.6 1.2 0.2 -1.3
Overall health rating 2.1 4.5 19.8 0.1 -1.5 2.3 2.2 4.4 -2.7 -1.9 -1.7 1.4 0.6 -1.0
Chest pain or discomfort 0.3 0.5 2.1 -1.4 0.3 -0.7 -0.6 0.6 -0.8 0.3 0.5 -0.9 -0.4 0.5
Had major operations 0.1 0.1 0.5 -0.1 0.3 0.2 0.0 -0.7 0.2 -0.1 -0.0 0.3 -0.0 0.0
Age at last live birth 0.6 0.8 2.1 1.0 -0.9 0.3 0.4 -0.2 -0.6 -1.4 -0.6 0.8 1.3 -1.4
Family relationship satisfaction 0.6 0.8 2.6 -1.6 0.9 -0.3 -0.7 -0.7 1.2 1.2 0.3 -0.7 -0.4 0.6
Leg pain on walking 3.4 4.3 9.4 1.1 -0.6 2.2 2.4 3.1 -2.2 -2.3 -2.2 2.5 0.9 -1.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.5 1.0 0.0 0.0 -0.1 -0.6 0.3 1.2 -0.2 0.5 0.8 -0.9
Commuting to job workplace: Car/motor vehicle 5.4 6.2 13.1 2.7 -3.3 2.1 2.5 0.4 -1.2 -1.7 -2.5 2.6 3.6 -2.9
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.7 -0.6 1.4 -1.4 -1.2 -1.9 1.7 0.7 1.2 -0.6 -0.2 0.1
Medication: Aspirin 0.3 0.4 3.0 -0.4 0.3 0.3 -0.0 0.6 0.4 -1.7 0.1 -0.5 -0.3 0.5
Supplements: Vitamin C 0.7 0.8 2.6 -0.4 1.1 -1.6 -1.1 -0.5 0.0 -0.3 1.2 -1.0 -0.7 0.9
Knee pain experienced in last month 1.3 2.0 4.1 0.7 -1.0 0.9 1.6 -0.8 -0.4 -2.0 -1.3 1.7 1.9 -1.8
Hypertension (Self-reported) 0.1 0.4 1.9 0.3 -0.1 0.5 0.9 -0.3 -0.9 -1.4 -0.5 0.5 0.0 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.5 -0.9 0.7 -0.3 -0.3 -1.2 0.7 0.2 0.1 -0.0 0.8 0.0
Illnesses of father: Heart disease 1.7 2.3 4.6 2.1 -1.6 1.9 1.8 1.1 -1.0 -1.3 -1.4 1.4 1.6 -1.3
Illnesses of siblings: Diabetes 0.4 0.5 2.6 -0.5 -1.1 0.0 0.3 0.8 -0.8 -1.6 -0.2 0.1 0.2 -0.0
Smoking status: Previous 0.3 0.5 1.2 -0.4 1.1 -0.8 -1.1 -1.0 0.1 0.8 0.4 -0.5 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 7.2 2.2 -1.6 2.7 2.4 2.1 -1.7 -0.0 -2.1 1.8 1.5 -1.5
Whole body fat-free mass 0.5 3.0 6.7 2.6 -2.3 2.4 2.0 0.9 -0.2 -0.7 -0.8 1.5 2.3 -1.5
Leg fat-free mass (right) 0.8 4.3 8.7 2.5 -2.8 2.9 2.6 1.8 -0.9 -0.7 -1.4 1.8 2.3 -1.8
Arm fat percentage (left) 2.0 8.1 15.0 2.4 -2.8 3.9 3.8 3.0 -1.9 -0.9 -2.5 2.7 3.4 -2.7
Average weekly red wine intake 1.1 1.6 3.3 1.5 -1.0 1.1 1.4 -1.1 -0.2 0.1 -1.5 1.3 1.8 -1.7
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.2 -0.2 1.4 -1.2 -1.0 -1.6 1.8 0.6 0.7 -0.4 0.4 -0.4
Mood swings 0.4 0.8 2.6 -1.1 0.7 -0.5 -0.9 1.6 -0.2 0.5 0.9 -0.8 -0.9 0.7
Loneliness, isolation 3.0 4.2 9.5 1.2 -1.4 3.1 2.7 1.4 -2.0 -1.7 -2.6 2.4 1.4 -1.6
Long-standing illness, disability or infirmity 5.8 8.9 15.1 2.2 -3.2 3.1 3.4 1.8 -3.1 -3.9 -3.2 3.2 2.4 -2.7
Ever had bowel cancer screening 0.9 1.1 2.3 0.3 -1.5 1.5 1.2 0.1 0.5 -0.8 -1.2 0.9 1.3 -1.1
Diabetes diagnosed by doctor 2.3 3.7 7.5 1.4 -1.3 1.8 2.1 1.8 -2.2 -2.7 -1.8 2.0 2.0 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 0.5 -1.2 0.4 0.6 -1.0 -0.6 -0.2 -0.7 0.4 0.5 -0.4
Friendships satisfaction 0.5 0.6 2.2 -1.5 0.6 -0.6 -0.7 -0.9 1.0 -0.0 0.1 -0.6 -0.2 0.4
Qualifications: nursing, teaching 0.2 0.3 0.9 0.1 0.1 -0.5 -0.1 -0.9 0.7 0.3 -0.1 -0.0 0.7 -0.7
Commuting to job workplace: Walk 1.4 1.5 4.8 -1.8 0.6 -0.8 -1.2 1.0 0.1 0.7 1.0 -1.2 -2.2 1.5
Eye problems/disorders: Cataract 0.6 0.7 2.7 -0.4 0.5 0.4 0.5 0.6 -1.6 -0.1 -0.1 -0.4 -1.5 1.0
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 8.2 0.5 -1.5 1.9 1.0 2.9 1.2 -0.3 -0.6 0.8 0.9 -0.4
Medication for cholesterol 0.3 0.5 1.9 0.2 1.4 -0.6 -0.4 0.2 0.9 1.0 0.2 -0.1 0.6 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.4 0.1 0.4 0.4 0.8 -0.3 -1.6 -1.5 -0.7 0.3 -0.1 0.1
Back pain experienced in last month 0.2 0.3 1.7 0.3 -0.5 0.4 0.3 -0.2 -0.6 -1.3 -0.2 0.3 0.8 -0.4
Mineral and other dietary supplements 0.6 0.9 4.3 0.9 -1.0 0.6 0.6 -0.1 -0.4 -0.1 -0.6 0.7 2.1 -1.4
Breast cancer (self-reported) 1.7 2.1 4.9 1.4 -0.5 0.7 1.0 -0.3 -0.5 -2.2 -1.3 1.7 2.1 -2.1
Asthma (self-reported) 0.4 0.8 1.6 0.4 -1.3 1.2 1.1 1.0 -0.6 -0.9 -0.9 0.7 0.6 -0.3
Osteoporosis (self-reported) 0.3 0.3 1.1 0.2 -0.7 0.7 0.7 0.3 -1.1 -0.8 -0.5 0.3 -0.1 -0.0
Osteoarthritis (self-reported) 2.7 3.5 7.8 1.2 -2.8 1.1 2.0 -0.5 -1.8 -2.3 -1.9 2.2 1.2 -2.2
Medication: Aspirin 0.3 0.4 2.7 -0.4 0.1 0.3 -0.1 0.7 0.2 -1.6 0.3 -0.5 -0.5 0.7
Medication: Gliclazide 0.4 0.5 2.0 0.7 -0.8 0.8 0.6 0.4 -0.4 -1.4 -0.7 0.3 0.7 0.0
Illnesses of father: None of the above (group 1) 2.6 3.2 5.3 -2.1 0.7 -1.7 -2.3 0.5 1.1 1.8 2.1 -2.1 -2.2 2.0
Smoking status: Current 0.6 1.0 2.7 0.8 -0.7 1.6 1.5 0.4 -1.0 -0.6 -1.5 1.0 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 -0.8 0.4 -1.2 -0.9 -1.5 -0.0 -0.7 1.1 -0.9 -1.0 1.3
Whole body water mass 0.5 3.1 6.8 2.6 -2.3 2.5 2.0 0.9 -0.1 -0.8 -0.8 1.5 2.3 -1.5
Leg predicted mass (right) 0.8 4.1 8.5 2.4 -2.7 2.9 2.5 1.9 -0.9 -0.7 -1.3 1.7 2.2 -1.7
Arm fat mass (left) 1.8 7.4 14.3 2.7 -2.9 3.8 3.6 2.6 -1.6 -0.8 -2.1 2.6 3.4 -2.5
Number of self-reported non-cancer illnesses 0.7 1.2 2.9 0.2 -1.3 1.7 1.3 1.7 -1.0 -0.9 -1.1 0.7 0.3 0.0
Average weekly champagne plus white wine intake 0.3 0.5 2.9 -0.2 -0.0 -0.2 0.3 -1.7 0.5 -0.3 0.1 0.3 0.9 -0.9
Miserableness 0.1 0.2 1.1 -0.3 -0.3 0.3 0.1 -0.1 -1.0 0.6 -0.6 0.3 0.3 -0.5
Guilty feelings 0.2 0.3 0.9 -1.0 0.5 -0.6 -0.5 0.4 -0.3 0.4 0.6 -0.4 -0.1 0.4
Wears glasses or contact lenses 0.4 0.4 2.4 -0.3 0.4 -0.6 -0.0 -1.6 -0.2 -1.1 0.2 -0.4 -0.5 0.2
Ever taken oral contraceptive pill 1.3 1.5 4.2 1.3 -2.1 1.2 1.2 0.4 -0.9 -0.7 -1.7 1.3 0.6 -1.1
Hearing aid user 1.4 1.6 7.5 -0.5 0.9 -1.2 -1.1 -0.7 2.7 2.1 0.9 -0.8 -0.4 0.4
Mother’s age at death 1.2 1.4 2.8 1.7 -0.5 1.6 1.7 0.3 -1.3 -1.0 -1.4 1.6 0.2 -0.6
Financial situation satisfaction 0.2 0.2 1.1 -0.4 -0.0 0.3 0.4 -0.7 -0.4 -1.1 -0.1 0.0 -0.3 0.5
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.0 0.8 -0.3 1.6 1.3 1.6 -1.7 -1.0 -1.2 1.1 -0.2 -0.1
Commuting to job workplace: Public transport 1.3 1.6 4.6 -0.5 2.2 -1.5 -1.4 -1.3 1.1 1.3 1.2 -1.1 -0.9 0.7
Eye problems/disorders: Glaucoma 2.7 3.1 10.1 -1.7 0.3 -0.1 -0.9 2.2 -0.5 1.5 1.5 -1.8 -2.8 3.2
Medication: Blood pressure 0.5 1.0 3.0 0.8 -0.7 1.0 1.2 0.0 -1.0 -1.7 -1.3 1.1 0.5 -0.9
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 -0.5 0.6 0.5 0.5 0.0 -0.2 0.3 0.1 0.3 -0.3 0.2
Supplements: Fish oil (including cod liver oil) 1.8 2.3 6.5 -1.3 1.6 -1.5 -1.4 -0.5 1.2 0.1 1.4 -1.7 -2.5 2.0
High cholesterol (Self-reported) 0.4 0.8 2.0 -1.0 0.6 -0.4 -0.8 -1.4 0.6 -0.9 0.7 -0.9 -0.6 1.2
Medication: Bendroflumethiazide 0.3 0.4 1.1 -0.7 0.6 -0.5 -0.2 -0.5 1.0 0.6 1.0 -0.7 -0.5 0.6
Medication: Paracetamol 1.2 1.9 6.1 1.2 -2.5 1.6 1.5 1.7 -1.2 -0.4 -1.2 1.3 0.4 -0.9
Medication: Lisinopril 0.4 0.6 1.7 -0.9 -0.7 -0.4 -0.1 0.6 -1.3 -0.8 0.2 -0.5 -1.2 0.5
Medication: Atorvastatin 0.8 1.0 2.4 0.7 -0.4 1.2 0.7 1.6 -0.3 -0.2 -0.7 1.1 1.3 -1.5
Illnesses of father: High blood pressure 1.8 2.2 4.5 1.5 -1.6 2.1 1.8 1.6 -1.6 -0.3 -1.7 1.2 1.0 -0.8
Alcohol drinker status: Never 0.6 0.8 1.4 -1.0 1.0 -1.0 -0.5 -0.9 0.5 0.8 1.1 -0.6 -1.2 0.8
Ever smoked 0.2 0.3 1.3 0.5 1.1 0.2 -0.4 -0.6 0.2 0.7 -0.4 0.2 0.5 -0.7
Basal metabolic rate 0.8 4.2 8.2 2.7 -2.6 2.9 2.5 1.6 -0.8 -0.8 -1.1 1.8 2.5 -1.8
Leg fat percentage (left) 1.4 5.2 9.3 2.0 -1.8 2.9 3.0 2.1 -1.9 -1.4 -1.9 2.3 2.9 -2.2
Arm fat-free mass (left) 0.4 1.9 5.0 2.2 -1.5 1.8 1.6 0.5 0.0 -0.5 -0.3 1.1 2.1 -1.3
Number of operations (self-reported) 2.2 3.2 8.5 1.4 -1.4 1.6 2.1 0.5 -2.0 -2.9 -2.0 2.1 0.9 -1.4
Average weekly beer plus cider intake 0.8 1.1 2.9 1.0 -0.9 0.5 0.9 0.1 -1.3 -1.7 -1.0 1.5 0.7 -1.2
Irritability 0.5 0.9 2.6 0.5 -0.6 0.8 0.9 1.6 -1.4 -0.5 -1.1 0.8 0.6 -0.8
Risk taking 1.1 1.6 4.3 -2.1 1.2 -1.1 -1.5 -0.1 0.5 0.9 1.3 -1.5 -0.7 1.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.8 -0.2 -0.7 -0.2 -0.3 -0.0 0.6 -0.4 0.4 -0.9 -0.8 0.8
Fractured/broken bones in last 5 years 0.9 1.2 3.5 -1.4 0.8 -1.9 -1.5 -0.3 0.1 -0.1 1.2 -1.4 -0.5 0.8
Age started oral contraceptive pill 0.6 0.7 2.0 1.0 -0.3 0.3 0.1 -1.4 1.4 -0.7 -0.2 0.3 1.3 -0.6
Diastolic blood pressure, automated reading 0.7 2.2 5.0 1.7 -0.6 0.5 1.0 -1.6 1.7 -1.6 -0.8 1.3 2.2 -2.1
Ever depressed for a whole week 0.7 0.9 1.9 0.7 -1.2 0.9 1.2 1.4 -0.5 -0.1 -1.2 1.0 0.3 -0.8
Unable to work because of sickness or disability 1.6 2.0 3.8 0.7 -0.9 1.6 1.7 1.0 -1.5 -2.0 -1.4 1.4 1.6 -1.4
Commuting to job workplace: Cycle 3.8 4.5 7.9 -2.1 1.8 -1.9 -2.3 -0.8 1.9 1.8 2.4 -2.1 -2.8 2.8
Myopia 1.7 2.4 5.1 1.7 -2.2 0.9 1.2 -0.4 -1.1 -0.8 -1.9 1.6 1.7 -2.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.6 -0.0 -0.2 -0.5 -0.8 0.0 0.5 0.6 0.4 -0.4 -0.4 0.0
Cholesterol lowering medication 0.3 0.5 3.2 0.1 -0.5 -0.2 -0.2 -1.8 0.9 -1.0 0.3 -0.2 -0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 2.9 3.6 7.9 1.4 -1.5 2.1 2.3 -0.1 -0.7 -2.3 -1.9 2.2 2.8 -1.8
Pain experienced in last month 1.0 1.7 3.7 -1.0 0.9 -1.0 -1.2 -0.9 0.3 1.9 1.0 -1.4 -1.9 1.7
Supplements: Calcium 0.5 0.5 1.3 -0.9 0.8 -0.7 -0.6 0.1 0.4 0.5 0.6 -0.8 -1.2 0.9
Basal cell carcinoma (self-reported) 0.4 0.5 2.0 -0.4 1.0 -0.2 -0.0 0.8 -0.3 -0.0 0.5 -0.5 -1.4 0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 -1.3 0.5 0.1 0.1 1.4 -0.6 -1.0 0.2 -0.3 0.2 0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.2 -0.3 -0.7 -0.0 0.0 -0.7 1.5 -1.2 0.0 0.4 0.8 -0.5
Heart disease (siblings) 2.4 2.9 6.2 1.4 -1.4 2.5 2.0 1.2 -1.9 -2.0 -1.9 1.5 1.2 -1.2
Alcohol drinker status: Previous 0.6 0.7 1.4 0.7 -1.1 1.2 1.1 1.1 0.5 0.7 -0.9 0.7 0.4 -0.5
Pack years of smoking 1.2 1.7 3.2 1.5 -0.7 1.7 1.7 0.8 -1.1 -1.8 -1.3 1.5 0.9 -0.9
Impedance of whole body 0.4 2.3 7.5 -1.6 1.1 -0.3 -0.3 2.7 -2.7 0.4 -0.5 -0.5 -1.9 1.3
Leg fat mass (left) 1.4 5.6 10.1 2.2 -2.2 3.2 3.1 2.4 -2.0 -1.5 -1.7 2.1 2.8 -2.0
Arm predicted mass (left) 0.4 1.9 5.1 2.3 -1.5 1.8 1.6 0.3 0.2 -0.5 -0.2 1.2 2.1 -1.3