Hub : Genes

POLB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.5490	0.0570	0.0e+00	0.380	NA	0.471	NA	0.435	9.3e-27	NA	6.2e-35	NA	1.5e-31
2	GTEx	Muscle Skeletal	0.0755	0.0291	3.8e-04	0.030	NA	0.065	NA	0.061	6.1e-04	NA	5.9e-07	NA	1.3e-06
3	GTEx	Skin Not Sun Exposed Suprapubic	0.3750	0.0630	3.4e-15	0.283	NA	0.233	NA	0.285	7.3e-16	NA	5.2e-13	NA	5.9e-16
4	GTEx	Skin Sun Exposed Lower leg	0.4550	0.0610	0.0e+00	0.376	NA	0.383	NA	0.404	1.2e-32	NA	1.8e-33	NA	1.2e-35
5	GTEx	Testis	0.2210	0.0720	1.0e-04	0.006	NA	0.025	NA	0.029	1.6e-01	NA	2.6e-02	NA	2.0e-02
6	METSIM	Adipose	0.0296	0.0150	5.7e-03	0.006	0.013	0.012	0.015	0.011	4.0e-02	3.9e-03	5.6e-03	2.3e-03	6.3e-03
7	NTR	Blood	0.0108	0.0060	1.7e-02	-0.001	0.003	0.000	0.003	-0.001	5.8e-01	3.1e-02	4.0e-01	3.4e-02	8.4e-01
8	YFS	Blood	0.0287	0.0106	1.7e-07	0.028	0.016	0.016	0.019	0.022	1.2e-09	2.9e-06	5.1e-06	5.9e-07	5.7e-08
9	TCGA	Bladder Urothelial Carcinoma	0.1070	0.0720	1.6e-06	0.091	0.071	0.065	NA	0.087	4.3e-08	1.3e-06	3.3e-06	NA	7.6e-08
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0943	0.0465	1.0e-06	0.044	0.051	0.048	NA	0.046	1.1e-05	2.2e-06	3.8e-06	NA	5.7e-06
11	TCGA	Lung Adenocarcinoma	0.0384	0.0210	1.3e-04	0.043	0.032	0.031	NA	0.032	7.6e-06	1.0e-04	1.2e-04	NA	1.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.0	5.7	0.1	1.4	-0.5	-0.7	-0.8	2.4	0.7	0.2	0.0	1.2	-0.8
Bipolar Disorder or Schizophrenia	1.0	2.4	9.7	-1.1	2.7	-1.4	-1.4	-0.7	3.1	0.5	1.2	-1.0	-0.6	1.1
Depressed Affect (Nagel 2018)	0.2	0.5	2.0	0.1	-0.2	0.6	0.5	1.2	-1.4	-0.8	-0.5	0.3	-0.1	-0.2
Depression (Nagel 2018)	0.7	1.0	2.2	0.9	-0.8	0.9	1.1	-0.2	-0.7	-1.1	-1.1	1.0	1.5	-1.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	5.9	-0.9	1.5	-1.3	-1.4	-2.4	1.6	1.6	1.4	-1.5	-0.2	0.5
Neuroticism (Nagel 2018)	0.1	0.3	1.1	0.2	0.1	0.1	0.3	1.1	-0.9	-0.9	-0.1	0.0	-0.3	-0.0
Schizophrenia (2018)	1.1	2.3	5.1	-1.5	2.3	-1.4	-1.2	-0.3	2.1	0.1	1.3	-1.4	-1.7	2.0
Schizophrenia vs Biploar Disorder	0.5	0.7	3.2	0.1	-0.5	0.6	0.4	1.8	-0.8	-0.6	-0.2	-0.2	-1.3	1.0
Worry (Nagel 2018)	0.3	0.5	2.5	-0.3	0.3	-0.3	-0.1	1.2	-0.3	-0.1	0.3	-0.5	-1.6	1.2
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	-1.4	-0.0	-1.1	-1.6	-1.0	1.9	1.3	1.2	-0.9	-0.5	0.8
Alzheimer’s Disease (in father)	0.9	0.9	4.3	0.2	1.1	-1.0	-0.2	-2.1	0.1	-1.3	-0.2	0.3	0.7	-1.2
Alzheimer’s Disease (including proxy)	0.9	1.3	4.4	-0.9	0.5	-1.5	-1.3	-1.9	2.1	0.5	0.9	-0.5	-0.1	-0.1
Crohns Disease (2017)	1.3	2.8	7.8	0.9	-1.4	1.9	1.6	1.5	-2.3	-2.8	-1.8	1.5	0.4	-1.0
Irritable Bowel Disease (IBD)	0.8	1.9	4.5	0.9	-0.3	1.4	1.3	1.7	-2.0	-2.1	-1.5	1.2	-0.7	-0.7
Ulcerative Colitis (UC)	0.4	0.7	3.2	0.3	0.2	0.7	0.7	1.8	-1.0	-0.6	-0.6	0.6	-1.3	-0.1
Major Depression (MDD)	1.4	1.7	5.1	0.0	-1.2	1.2	1.4	1.8	-1.4	-2.3	-1.4	1.1	-0.2	-0.3
Reaction Time	0.3	0.5	1.1	0.4	-0.8	0.4	0.8	1.0	-1.1	-0.6	-0.9	0.7	-0.6	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	5.9	0.6	0.4	-0.4	0.1	-2.4	0.2	-0.1	-0.1	0.1	1.0	-0.6
Breast Cancer	0.1	0.3	0.9	0.1	-0.8	0.4	0.1	0.6	-0.3	0.1	-0.1	-0.4	-0.8	0.9
Ovarian Cancer	0.6	0.9	4.0	-0.8	-0.6	-0.1	-0.7	0.6	1.1	2.0	0.7	-1.1	-0.1	0.9
Prostate Cancer	0.4	0.5	2.7	0.2	0.2	-0.2	-0.8	-1.0	0.8	1.6	0.5	0.0	0.2	-0.3
Age at First Birth	0.6	0.8	2.5	-0.4	0.3	-0.5	-0.8	1.2	1.6	1.4	1.0	-0.8	-0.3	0.6
Bipolar Disorder (2011)	0.9	0.9	3.2	0.5	1.0	-0.4	-0.2	-1.6	1.8	-0.2	0.2	0.2	1.2	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	0.6	-1.3	0.8	1.2	-0.6	-0.2	-0.9	-0.8	1.1	1.1	-0.8
Coronary Artery Disease (CAD)	2.3	2.8	4.6	1.2	-0.6	2.0	1.9	0.7	-2.1	-1.6	-1.9	1.9	1.4	-2.0
Crohns Disease (2012)	1.1	1.7	10.3	-0.1	0.2	0.5	0.2	1.3	-2.4	-3.2	-0.8	0.1	-0.2	0.2
Mean Putamen Volume	1.2	1.3	3.5	-1.4	1.9	-0.7	-1.0	0.2	1.0	0.3	1.0	-1.5	-0.9	1.6
Fasting Glucose	1.2	1.4	2.4	-1.0	1.1	-1.5	-1.2	-1.1	0.8	1.5	1.3	-1.1	-1.3	1.1
HbA1C	2.0	2.2	5.1	-1.7	1.6	-1.2	-1.3	1.2	-1.3	-0.7	1.2	-1.4	-2.3	1.9
HDL Cholesterol	0.1	0.1	0.3	-0.5	-0.0	0.3	0.4	0.1	-0.4	0.3	-0.3	0.5	-0.3	-0.0
LDL Cholesterol	0.6	1.0	2.9	-0.8	0.8	-1.7	-1.0	-1.5	0.6	0.6	1.1	-1.1	-0.0	0.4
Lupus	2.2	3.3	7.6	1.1	-1.8	2.0	2.3	2.2	-2.8	-1.0	-2.0	1.8	0.5	-1.5
Neuroticism (2016)	0.8	1.2	4.4	-0.9	-0.1	0.5	0.1	1.6	-0.6	0.8	0.2	-0.6	-2.1	1.8
Primary Biliary Cirrhosis	3.9	5.6	13.5	1.8	-2.1	2.5	2.8	1.9	-3.7	-2.7	-2.4	2.4	0.4	-1.8
Rheumatoid Arthritis	0.1	0.2	0.4	-0.5	-0.6	0.3	0.0	0.6	-0.3	0.1	-0.1	-0.3	-0.4	0.5
Schizophrenia (2014)	1.4	3.1	7.9	-1.6	2.8	-1.9	-1.6	-1.1	2.5	0.2	1.6	-1.5	-1.3	1.8
Triglycerides	1.2	1.9	2.6	-1.3	1.6	-1.4	-1.4	-0.8	0.9	1.4	1.5	-1.6	-1.5	1.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.7	-0.8	0.4	0.2	0.3	0.5	-1.5	-1.6	-0.4	0.3	-0.7	0.2
Ulcerative Colitis	0.2	0.3	0.9	-0.4	0.9	0.6	0.5	0.5	-0.2	-1.0	-0.3	0.5	-0.7	-0.1
Blood Eosinophil Count	0.4	3.3	13.5	-1.1	3.7	-2.0	-1.4	-1.8	-0.9	-0.5	1.4	-1.8	-1.8	1.9
Blood Platelet Count	0.1	1.7	6.5	-1.4	1.3	-1.1	-0.7	-1.7	2.5	1.7	0.2	-0.4	-0.3	0.4
Blood Red Count	1.3	12.9	69.6	1.9	2.0	-0.8	-0.6	-3.2	8.3	6.0	0.6	0.2	3.1	-2.5
Blood White Count	0.2	1.1	7.2	-0.2	1.7	0.2	0.2	0.4	1.2	2.7	-0.3	0.5	-0.5	-0.3
Heel T-Score	0.6	4.7	8.6	-2.4	2.5	-2.9	-2.5	-2.8	2.5	-1.0	2.1	-1.7	0.1	1.3
BMI	0.5	2.7	6.4	2.0	-2.0	1.9	2.0	0.3	-0.5	-1.1	-0.9	1.4	2.5	-1.7
Height	0.3	5.7	15.3	2.2	-2.5	3.2	2.6	3.9	-3.0	-1.4	-1.8	1.7	1.1	-0.9
Waist Hip Ratio (WHR)	0.1	0.4	3.6	-0.5	0.2	0.4	-0.1	1.9	0.7	-0.1	0.3	-0.1	0.3	0.3
Systolic Blood Pressure	0.3	1.3	3.2	0.1	0.9	-1.6	-1.1	-1.8	-1.2	-0.4	1.0	-1.1	-1.5	1.0
Smoking Status	0.2	0.5	1.3	0.2	0.6	1.0	0.8	-0.4	-1.1	-0.5	-1.0	0.6	-0.3	-0.3
Allergy or Eczema	0.1	0.2	0.9	-0.1	-0.0	-0.2	0.2	1.0	-0.6	0.7	-0.1	-0.4	-0.1	0.3
Cardiovascular Disease	0.2	0.5	3.0	0.4	0.1	0.2	0.4	-0.7	-1.2	-1.7	-0.3	0.1	-0.1	0.4
Hypothyroidism (self reported)	0.5	1.1	3.1	-1.2	-0.1	-1.3	-1.1	0.5	-0.9	-0.3	0.8	-1.0	-1.8	1.3
Respiratory disease	0.8	1.8	3.3	0.8	-1.5	1.7	1.8	1.0	-1.4	-1.2	-1.6	1.5	1.0	-1.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	5.2	0.8	-0.8	1.2	1.3	0.8	-1.7	-2.3	-1.2	1.1	1.3	-1.0
Lung FEV1/FVC ratio	0.0	0.2	0.8	0.5	0.2	0.9	0.1	0.8	0.2	0.1	-0.3	-0.4	0.4	-0.0
Lung FVC	0.2	1.3	4.7	-1.4	0.9	-1.0	-0.9	-0.6	-0.5	-0.1	0.7	-1.0	-2.2	1.7
Neuroticism	0.1	0.1	0.8	0.0	-0.3	-0.1	0.0	0.9	-0.4	-0.4	0.1	-0.2	-0.4	0.5
Chronotype (morning person)	0.5	1.1	2.4	-1.3	1.5	-0.8	-0.4	-0.6	-0.7	-1.1	0.9	-0.8	-1.5	1.2
Hair Pigment	0.3	9.4	20.5	2.9	-2.9	4.4	4.5	2.2	-1.2	-1.6	-3.7	3.4	2.3	-2.7
Tanning	0.5	6.3	13.3	-3.2	2.5	-3.5	-3.6	-1.9	2.3	1.1	2.7	-2.3	-1.5	1.4
Hand grip strength (left)	0.1	0.2	1.6	0.1	0.3	0.3	-0.0	0.7	-1.3	-0.2	-0.0	-0.1	0.0	0.2
Number of treatments/medications taken	0.6	1.0	4.7	-1.0	-0.8	0.9	0.9	2.2	-0.8	-1.2	-0.4	0.0	-0.8	0.8
Average weekly spirits intake	0.1	0.2	0.9	0.1	0.2	-0.0	0.2	-0.5	-0.7	-1.0	0.1	0.1	0.0	0.2
Sensitivity / hurt feelings	0.4	0.8	5.0	0.1	0.5	0.8	0.7	2.2	-0.9	-0.9	-0.4	0.4	0.1	-0.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	0.5	-1.2	1.2	1.1	0.5	-0.8	-0.4	-1.1	1.0	1.4	-1.0
Hearing difficulty/problems: Yes	1.2	1.8	8.4	-1.1	1.3	-0.9	-1.4	0.2	2.9	1.5	1.4	-1.1	-0.2	0.6
Relative age of first facial hair	0.6	1.3	3.0	1.2	-1.2	1.3	1.7	-0.1	-1.0	0.1	-1.6	1.5	0.6	-0.7
Other serious medical condition/disability diagnosed by doctor	4.0	5.2	10.7	1.5	-2.7	1.8	2.5	0.4	-3.3	-3.1	-2.5	2.2	1.8	-2.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.5	0.9	-0.3	-0.7	-0.1	0.8	1.1	0.9	-0.7	-0.0	0.6
Ever had hysterectomy (womb removed)	0.7	0.8	3.6	0.4	-1.1	1.9	1.1	0.6	0.9	-0.4	-0.9	0.7	0.7	-0.0
Systolic blood pressure, automated reading	0.4	1.1	3.9	-0.1	1.1	-1.3	-0.9	-2.0	-0.1	-1.4	1.1	-1.0	-0.4	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.1	0.5	0.4	-0.2	0.1	0.7	-0.1	-0.7	-0.0	0.4	1.0	-0.5
Angina	0.4	0.6	1.5	0.1	0.4	1.0	1.0	1.2	-0.7	0.1	-0.7	0.8	0.7	-0.7
Medication for hormone replacement therapy	1.0	1.1	3.1	-1.4	0.0	-0.2	-0.5	0.5	-1.6	-0.0	1.0	-1.0	-1.4	1.8
Vitamin and mineral supplements	0.1	0.2	0.6	-0.1	0.6	0.4	0.1	-0.4	-0.1	0.7	-0.2	0.3	0.6	-0.3
Supplements: Zinc	0.2	0.3	0.7	-0.2	0.4	-0.5	-0.7	-0.5	0.8	-0.8	0.4	-0.4	0.0	0.0
Medication: Co-codamol	0.2	0.3	2.5	-0.5	0.0	-0.2	0.0	0.0	-0.2	-1.6	0.3	-0.0	0.4	0.0
Medication: Metformin	1.6	2.2	7.6	1.0	-0.8	1.4	1.7	1.5	-1.8	-2.8	-1.4	1.3	1.0	-0.8
Diabetes (father)	0.5	0.6	1.7	-0.6	1.3	-1.0	-0.4	-0.7	0.6	0.9	0.3	-0.3	-1.1	0.6
Diabetes (mother)	0.5	0.7	2.9	0.1	-0.5	0.4	0.6	1.4	-1.2	-1.7	-0.2	-0.1	0.3	0.1
Severe depression (siblings)	2.0	2.3	3.8	1.9	-1.9	1.4	1.7	0.2	-0.2	-1.8	-1.4	1.5	1.7	-1.6
Pack years adult smoking proportion	1.1	1.7	3.2	1.6	-0.5	1.6	1.7	0.7	-1.3	-1.8	-1.3	1.4	0.8	-0.8
Impedance of leg (right)	0.4	1.9	4.3	-1.4	1.6	-1.0	-1.0	1.4	-2.1	-0.1	0.3	-0.9	-2.0	1.7
Leg fat-free mass (left)	0.9	4.5	9.4	2.7	-2.8	3.1	2.7	1.7	-0.9	-0.9	-1.4	1.8	2.4	-1.8
Trunk fat percentage	2.1	8.5	18.1	2.0	-2.3	4.0	3.9	4.3	-3.1	-1.2	-2.6	2.5	2.4	-2.1
Hand grip strength (right)	0.1	0.2	2.1	0.4	0.0	0.5	0.2	0.1	-1.4	-0.2	-0.0	-0.1	0.3	0.2
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.6	0.3	0.6	0.0	0.9	-0.3	-0.0	0.1	-0.1	-0.8	0.7
Current tobacco smoking	0.7	1.2	2.8	0.9	-0.8	1.7	1.6	0.6	-1.2	-0.9	-1.6	1.1	0.0	-0.3
Average weekly fortified wine intake	0.2	0.2	0.5	0.2	-0.5	-0.7	-0.4	-0.7	0.3	-0.4	0.0	-0.1	-0.5	-0.0
Maternal smoking around birth	1.3	1.8	9.2	0.6	0.3	0.9	1.4	1.1	-1.7	-3.0	-1.1	0.8	1.0	-0.8
Fed-up feelings	0.4	0.7	4.0	-0.1	-0.7	0.7	0.3	2.0	-1.3	-0.9	-0.4	0.2	0.0	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.9	0.6	-0.5	0.3	0.6	-0.7	-0.6	-0.2	-0.6	0.8	1.4	-0.9
Relative age voice broke	0.1	0.1	0.5	-0.4	0.2	0.1	-0.1	-0.3	0.5	0.7	-0.1	-0.0	0.2	0.1
Taking other prescription medications	0.8	1.2	2.6	0.2	-1.3	1.3	1.3	1.6	0.1	-1.5	-1.2	0.7	1.2	-0.7
Age when periods started (menarche)	0.1	0.4	2.4	0.5	-0.3	-0.2	-0.4	0.3	1.6	0.3	-0.3	0.4	0.1	-0.8
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	4.2	1.3	-1.5	2.1	1.3	1.6	1.2	0.3	-1.1	1.3	1.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.1	-0.7	1.2	-1.0	-1.1	-0.6	0.6	-0.5	1.4	-0.6	-0.1	0.7
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	6.2	2.2	-2.5	2.0	1.8	-0.7	-1.1	-1.3	-2.2	2.3	1.9	-2.0
Qualifications: CSEs or equivalent	0.0	0.1	0.2	-0.1	0.1	0.2	0.0	0.4	-0.4	0.4	0.0	0.1	0.0	-0.0
Serious illness, injury or assault to yourself	0.2	0.3	1.9	-0.2	-0.7	0.0	0.1	-0.0	-0.6	-1.4	0.1	-0.0	-0.4	0.4
High blood pressure	0.2	0.4	1.6	0.3	-0.0	0.6	1.0	-0.3	-0.9	-1.3	-0.6	0.6	0.2	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	-0.3	0.1	-1.1	-0.8	0.6	-0.2	0.8	0.8	-1.2	-0.2	0.8
Multivitamins +/- minerals	0.1	0.1	0.5	0.0	-0.3	-0.4	-0.4	0.2	0.7	-0.2	0.1	-0.2	0.2	-0.1
Stomach or abdominal pain in last month	0.2	0.2	1.0	-0.2	0.3	0.0	0.3	0.8	-0.3	-1.0	-0.2	-0.3	0.7	0.2
Supplements: Glucosamine	1.3	1.6	3.3	0.7	-1.2	1.6	1.5	1.5	-1.0	-1.1	-1.2	1.8	0.5	-1.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.6	-0.4	1.4	-1.4	-1.5	-1.6	0.8	0.1	1.2	-0.9	-0.3	1.0
Medication: Atenolol	1.3	1.6	2.9	-1.7	1.3	-1.6	-1.5	-1.0	-0.0	0.1	1.4	-1.4	-1.3	1.4
Medication: Levothyroxine sodium	0.6	1.0	2.5	-1.6	1.3	-1.1	-1.0	0.1	-0.1	1.1	0.6	-0.8	-1.1	1.0
Sitting height	0.2	1.3	5.4	0.9	-0.6	1.5	1.1	1.8	-2.3	-0.6	-0.5	0.5	-0.1	0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.4	-0.1	-0.6	-0.2	-0.5	0.2	-0.5	0.3	-0.1	0.9	-0.5
High blood pressure (mother)	0.2	0.2	0.9	-0.1	-0.6	-0.1	-0.0	0.2	1.0	-0.9	0.0	-0.3	0.4	-0.1
Body mass index (BMI)	1.2	5.1	10.2	2.5	-2.4	3.0	3.0	1.3	-0.6	-1.0	-1.5	2.2	3.2	-2.5
Impedance of leg (left)	0.5	2.6	5.3	-1.9	1.8	-1.5	-1.3	1.6	-2.2	0.0	0.5	-1.1	-2.3	1.8
Leg predicted mass (left)	0.9	4.5	9.5	2.6	-2.8	3.1	2.7	1.8	-0.8	-0.9	-1.4	1.8	2.4	-1.8
Trunk fat mass	2.1	9.2	17.5	2.6	-2.6	4.2	4.0	4.1	-2.9	-1.2	-2.5	2.7	2.9	-2.4
Waist circumference	1.3	4.7	9.2	1.9	-2.1	3.0	2.7	2.8	-0.5	-0.8	-1.4	1.9	2.9	-2.0
Number of incorrect matches in round	1.1	1.9	7.0	1.4	-0.9	0.5	1.1	-0.1	-0.3	-2.6	-1.1	1.4	1.7	-1.9
Past tobacco smoking	0.2	0.3	1.3	-0.1	-1.1	0.1	0.6	0.9	0.4	-0.6	0.1	0.1	0.3	0.3
Alcohol usually taken with meals	2.0	3.3	11.6	1.2	-1.6	0.6	0.6	-0.8	2.6	1.4	-1.0	1.1	3.4	-2.9
Nervous feelings	0.6	1.2	2.8	0.9	-1.1	1.2	1.4	1.7	-1.2	0.0	-1.3	1.1	0.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	4.0	-0.0	-0.7	0.8	0.7	1.3	-2.0	-0.4	-0.7	0.5	-0.5	0.1
Hearing difficulty/problems with background noise	0.9	1.4	4.5	-2.1	1.1	-1.0	-1.2	0.2	1.3	0.1	1.1	-1.4	-1.0	1.1
Hair/balding pattern: Pattern 2	2.8	3.6	6.1	-2.0	2.1	-2.5	-2.3	-1.7	1.4	0.2	2.1	-2.1	-1.9	1.7
Had menopause	0.4	0.5	2.8	-0.2	0.8	-0.3	-0.6	-0.6	1.7	0.3	0.7	-0.7	0.6	0.3
Had other major operations	6.7	8.2	16.3	3.0	-2.6	2.8	3.2	1.0	-2.1	-4.0	-3.3	3.3	2.2	-2.7
Forced vital capacity (FVC)	0.2	0.7	2.6	0.5	-0.9	0.2	0.0	0.9	-1.6	0.6	-0.1	-0.2	-1.4	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.9	-1.0	1.4	-1.3	-1.5	-0.9	1.4	-0.2	1.7	-1.0	-0.1	1.0
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	6.2	1.9	-1.6	1.6	2.2	0.7	-0.7	-2.5	-2.1	2.2	2.1	-2.3
Qualifications: None of the above	0.5	1.2	6.0	0.1	-1.1	0.7	0.5	0.3	-1.8	-2.4	-0.1	0.7	-0.8	-0.3
Financial difficulties in last 2 years	0.4	0.6	1.6	0.3	-0.6	0.8	0.7	1.2	-1.1	-0.6	-0.9	0.7	0.5	-0.3
Mouth/teeth dental problems	0.5	0.7	5.6	0.7	0.5	-0.9	-0.2	-2.4	0.4	-0.1	-0.1	-0.0	-0.2	-0.6
Heart attack	0.5	0.6	2.3	-1.5	0.8	-0.1	-0.1	1.4	-0.7	-1.1	0.3	-0.4	-0.1	0.4
Allergy	0.2	0.4	2.0	-0.1	1.2	-0.0	-0.2	-1.4	0.6	0.3	0.2	0.2	-0.4	-0.2
Pain all over the body in last month	1.8	1.9	4.3	1.9	-2.1	1.5	1.2	0.6	-0.9	-0.5	-1.3	1.3	1.7	-1.4
Diabetes (self-reported)	1.3	2.0	4.2	0.7	-1.1	1.3	1.6	1.6	-1.7	-2.1	-1.3	1.4	1.3	-1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.9	0.1	0.1	0.2	-0.1	1.3	-0.7	1.7	0.0	-0.6	-0.5	0.7
Medication: Ramipril	0.1	0.1	0.3	0.3	0.1	-0.3	-0.2	0.4	-0.5	-0.3	0.1	-0.1	-0.1	0.0
Medication: Simvastatin	0.2	0.3	1.0	-0.5	-0.3	0.0	0.1	-1.0	1.0	-0.5	0.1	-0.3	-0.4	0.7
Fluid intelligence score	0.3	0.6	1.8	-0.0	0.1	-0.6	-0.5	-1.4	1.2	1.3	0.6	-0.6	0.3	0.3
Illnesses of siblings	0.9	1.3	3.4	-0.1	1.8	-1.3	-1.3	-1.8	0.6	0.7	1.3	-0.8	-0.6	0.7
Neuroticism score	0.2	0.4	2.9	-0.1	0.2	0.2	0.1	1.7	-0.8	-0.2	-0.3	0.1	-0.4	0.3
Weight	1.4	6.7	13.1	2.8	-2.8	3.6	3.3	2.6	-1.6	-0.9	-1.7	2.3	3.2	-2.2
Impedance of arm (right)	0.4	2.1	10.7	-0.7	-0.2	0.8	0.8	3.3	-2.6	-0.3	-1.7	0.5	-0.4	-0.1
Arm fat percentage (right)	2.2	8.6	15.1	2.5	-2.9	3.9	3.8	3.1	-1.9	-1.1	-2.6	2.8	3.6	-2.9
Trunk fat-free mass	0.4	2.3	6.1	2.5	-2.0	1.9	1.5	0.3	0.1	-0.7	-0.5	1.3	2.2	-1.4
Hip circumference	0.7	2.9	5.7	1.9	-1.6	2.4	2.3	2.1	-0.9	-0.2	-0.9	1.3	2.2	-1.4
Time employed in main current job	0.2	0.2	1.4	0.2	0.3	-0.2	-0.1	-0.2	0.3	-1.2	0.0	-0.0	0.8	-0.1
Alcohol intake versus 10 years previously	1.8	2.6	12.4	0.3	-1.1	2.1	1.3	3.5	-2.2	-0.6	-1.6	0.9	0.0	-0.5
Father’s age at death	0.1	0.2	0.4	-0.2	0.4	0.2	0.3	0.6	-0.2	-0.2	-0.6	0.3	0.6	-0.1
Worrier / anxious feelings	0.2	0.4	3.3	0.0	0.0	0.7	0.4	1.8	0.2	0.1	-0.1	0.1	-0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	5.0	0.2	-1.1	1.4	0.9	2.2	-0.7	1.3	-0.8	0.7	0.6	-0.5
Falls in the last year	0.2	0.3	0.8	-0.3	-0.6	0.3	0.3	0.9	-0.8	0.4	-0.4	0.5	0.6	-0.6
Hair/balding pattern: Pattern 3	2.0	3.1	5.3	2.1	-1.3	2.0	1.8	0.8	-0.2	-1.2	-2.0	2.3	2.1	-2.2
Number of live births	0.4	0.5	1.1	0.4	-0.9	0.9	0.9	1.0	-0.4	-0.5	-1.0	0.7	0.6	-0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.3	0.6	-0.9	0.3	0.0	0.9	-1.5	0.2	-0.2	-0.1	-1.1	0.9
Pulse rate	1.3	2.2	6.4	1.5	-0.8	1.8	1.7	0.8	0.7	-0.4	-1.0	1.8	2.5	-1.9
Happiness	0.5	0.6	1.7	0.3	0.1	1.2	0.6	-0.5	1.0	0.0	-0.9	0.5	1.3	-0.7
Noisy workplace	0.8	1.0	4.0	-0.4	0.0	0.6	0.4	1.1	-1.3	-2.0	-0.0	-0.0	-1.6	0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.6	0.5	-0.7	-0.9	-1.0	-0.9	1.6	1.4	0.4	-0.1	1.6	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.8	-0.2	-0.1	0.2	0.4	2.0	-1.4	-0.8	-0.5	-0.3	-0.4	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	4.0	-0.6	-1.1	0.9	0.9	1.2	-2.0	-1.0	-0.5	0.6	-0.4	0.3
Asthma	0.5	0.9	1.9	0.3	-1.4	1.3	1.1	1.2	-0.9	-1.2	-1.0	0.7	0.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	4.4	-0.7	0.3	0.3	0.1	0.9	-0.0	-2.1	0.0	-0.0	-0.6	0.6
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.4	0.3	0.3	0.3	0.2	-0.4	-0.0	-0.1	0.0	0.1	0.4
Depression (self-reported)	0.1	0.1	0.5	-0.4	0.3	0.1	0.3	-0.6	0.7	-0.0	-0.0	-0.1	0.2	-0.3
Medication: Lansoprazole	0.5	0.6	1.9	-1.0	0.6	-0.9	-0.7	-1.4	0.8	0.4	0.9	-0.2	0.1	-0.3
Prospective memory result	0.1	0.1	0.8	0.4	-0.1	-0.1	-0.3	-0.5	0.9	0.1	0.3	0.1	0.4	0.1
Lung cancer (father)	1.6	1.9	4.0	-1.8	0.1	-2.0	-1.7	-1.0	-0.4	-0.6	1.6	-1.4	-1.7	1.1
Illnesses of mother	0.5	0.6	5.0	-0.2	0.1	0.9	-0.1	0.6	-0.3	2.2	0.1	-0.0	-0.7	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	5.5	1.1	-1.5	1.3	1.1	1.8	-2.3	-0.2	-1.0	0.5	-0.9	0.7
Pulse wave Arterial Stiffness index	0.8	0.9	4.7	-0.4	2.2	-0.4	-0.6	-0.8	1.4	0.6	1.1	-0.5	0.0	-0.2
Impedance of arm (left)	0.5	2.3	11.9	-1.0	-0.1	0.9	0.8	3.5	-2.7	0.4	-1.5	0.3	-0.9	0.6
Arm fat mass (right)	2.0	8.1	14.4	2.7	-3.0	3.8	3.7	2.8	-1.9	-1.1	-2.3	2.7	3.5	-2.8
Trunk predicted mass	0.4	2.2	6.0	2.5	-1.9	1.9	1.5	0.3	0.2	-0.7	-0.5	1.3	2.2	-1.3
Standing height	0.2	2.3	9.8	1.2	-1.2	2.0	1.4	3.1	-2.3	-0.2	-0.9	0.7	0.6	-0.0
Length of working week for main job	0.5	0.6	2.1	0.6	-0.3	-0.2	-0.1	-1.3	0.9	-0.5	0.1	0.2	1.4	-0.9
Exposure to tobacco smoke at home	1.8	2.0	3.9	0.9	-1.4	1.5	1.7	1.0	-1.8	-0.9	-1.9	2.0	0.5	-1.4
Breastfed as a baby	0.2	0.2	0.9	-0.4	-0.2	-0.2	-0.3	-0.1	0.7	1.0	0.2	0.1	0.5	-0.6
Tense / ‘highly strung’	0.2	0.3	1.1	-0.3	-0.9	0.0	-0.1	1.1	-0.2	0.3	-0.2	-0.3	-0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	0.7	-1.1	0.7	0.9	1.0	-0.7	-0.7	-0.4	0.7	0.2	-0.5
Hair/balding pattern: Pattern 4	0.8	1.9	3.5	1.0	-1.2	1.8	1.8	1.0	-1.9	-0.4	-1.5	1.4	1.0	-1.1
Birth weight of first child	1.4	2.5	5.5	-2.1	1.0	-1.6	-2.0	0.1	1.0	2.3	1.8	-1.6	-1.0	1.4
Peak expiratory flow (PEF)	0.3	0.6	2.9	0.5	-0.9	0.6	0.4	1.1	-1.7	0.1	-0.4	0.1	-0.7	0.8
Pulse wave reflection index	2.1	2.6	5.5	-1.4	2.3	-1.7	-2.1	-1.6	2.0	1.4	1.7	-1.4	-1.1	0.6
Ever highly irritable/argumentative for 2 days	1.7	2.0	4.0	1.3	-0.8	1.0	1.5	0.5	-1.3	-1.3	-2.0	1.7	1.4	-1.9
Loud music exposure frequency	1.1	1.2	6.2	-0.7	-1.3	0.1	0.5	2.5	-0.9	-1.0	-0.3	-0.4	-1.3	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.6	0.4	-1.6	0.6	-0.1	0.9	-0.4	1.5	-0.2	-0.1	0.8	-0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.1	-0.5	1.4	-0.8	-1.1	0.1	1.2	0.5	1.0	-0.9	0.1	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.8	-0.6	-0.6	-0.2	-0.1	-0.5	1.3	-1.3	0.2	0.2	0.2	-0.0
Medication: Paracetamol	1.1	1.8	4.5	0.8	-2.1	1.5	1.5	2.0	-1.7	-0.4	-1.2	1.1	-0.5	-0.5
Headache pain in last month	0.2	0.3	1.2	0.1	-0.3	-0.0	-0.0	1.1	0.4	-0.7	-0.6	0.2	0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.5	-0.6	-0.6	-0.4	-0.7	0.5	-0.1	-0.0	-0.0	0.5	-0.5
Glaucoma (self-reported)	1.7	2.0	6.1	-1.4	0.8	-0.3	-0.8	1.4	-1.0	1.0	1.0	-1.5	-2.4	2.5
Gout (self-reported)	0.6	0.8	7.2	-0.2	0.8	0.1	-0.3	0.3	-0.0	2.7	0.1	-0.6	-0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.9	-1.4	-0.4	-1.1	-1.2	0.5	0.3	0.9	0.8	-1.1	-1.7	1.5
Medication: Amlodipine	0.5	0.7	1.3	-1.1	0.9	-0.4	-0.6	0.8	0.1	1.0	0.6	-1.0	-1.1	1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.9	-0.9	1.4	-0.9	-0.8	-0.8	0.5	0.3	0.8	-0.7	-1.1	0.9
Birth weight	0.3	0.6	3.2	-0.5	-0.9	0.6	0.1	1.0	0.7	1.8	0.3	-0.1	-0.5	0.5
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.8	-1.2	1.0	-1.9	-1.4	-1.1	-0.1	-0.8	1.8	-1.6	-2.0	1.6
High blood pressure (siblings)	0.5	0.7	3.3	-1.5	-0.3	0.1	-0.1	1.8	0.8	0.0	0.1	-0.9	-0.3	0.7
Forced vital capacity (FVC), Best measure	0.5	1.8	5.6	1.2	-1.8	1.4	1.2	1.9	-2.4	-0.0	-1.1	0.6	-0.8	0.6
Body fat percentage	2.0	7.8	14.7	2.2	-2.4	3.8	3.8	3.7	-2.6	-1.2	-2.4	2.5	2.8	-2.3
Leg fat percentage (right)	1.5	5.6	10.2	2.2	-2.0	3.2	3.2	1.9	-1.8	-1.5	-2.0	2.3	3.0	-2.2
Arm fat-free mass (right)	0.3	1.3	4.1	2.0	-1.4	1.6	1.4	0.4	0.0	-0.6	-0.1	0.8	1.5	-0.8
Exposure to tobacco smoke outside home	2.9	3.9	12.8	1.0	-1.0	1.3	2.0	2.5	-3.6	-3.0	-1.9	1.7	0.2	-0.9
Comparative body size at age 10	0.4	1.1	8.4	0.2	-0.2	-0.3	-0.2	-0.7	-0.5	-2.9	1.0	-0.8	-0.7	1.0
Number of full brothers	0.4	0.6	3.3	-0.4	-0.4	-0.1	0.0	0.4	-1.8	-0.3	-0.2	-0.5	-1.2	0.8
Worry too long after embarrassment	0.2	0.4	2.4	0.2	1.0	-0.3	-0.3	-0.0	1.5	0.4	0.4	-0.1	0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.1	-1.2	0.0	-0.9	-1.1	-1.5	1.8	1.1	1.1	-1.0	-0.3	0.9
Wheeze or whistling in the chest in last year	1.3	2.3	4.8	1.3	0.3	1.1	1.2	1.1	-1.8	-2.0	-1.6	1.4	2.2	-1.8
Number of children fathered	4.8	5.4	8.2	-2.6	2.7	-2.6	-2.9	-1.3	1.9	1.9	2.6	-2.5	-1.8	2.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.9	0.4	-1.1	1.0	0.8	1.4	0.6	0.6	-0.4	0.4	0.7	-0.4
Age at first live birth	0.4	0.7	2.7	-0.1	0.6	-1.4	-1.0	-1.6	0.1	-0.4	0.7	-0.5	-0.1	-0.2
Pulse wave peak to peak time	1.0	1.1	5.4	0.5	-2.3	0.7	0.8	1.2	-1.5	-0.4	-1.2	0.6	0.1	0.3
Health satisfaction	4.5	5.8	10.4	2.4	-2.3	2.3	2.6	1.2	-1.3	-2.7	-2.5	2.5	3.2	-2.7
Shortness of breath walking on level ground	1.5	1.8	2.9	1.2	-1.0	1.3	1.7	0.2	-0.8	-1.7	-1.4	1.4	1.6	-1.5
Qualifications: College or University degree	0.7	2.1	8.4	0.2	0.4	-1.2	-1.2	-1.7	2.9	2.7	0.7	-0.9	-0.0	0.6
Eye problems/disorders: None of the above	1.8	2.1	5.5	1.5	-1.2	0.2	0.3	-2.3	1.5	-0.2	-0.6	1.3	2.1	-2.2
Mouth/teeth dental problems: Loose teeth	1.6	1.9	6.2	-2.0	2.5	-1.3	-1.0	-0.8	-0.5	0.8	1.2	-1.3	-1.1	1.5
Emphysema/chronic bronchitis	0.9	1.1	2.7	1.1	-0.5	1.0	1.4	0.0	-1.1	-1.6	-1.0	0.8	1.0	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	3.8	-0.1	0.7	-1.0	-1.2	-1.3	0.6	2.0	0.9	-0.8	0.0	0.2
Neck or shoulder pain in last month	1.7	2.4	4.2	1.6	-1.4	1.7	1.6	0.1	-0.4	-1.1	-1.9	1.7	2.0	-1.9
Medication: Blood pressure	0.5	0.8	2.1	-1.1	1.4	-0.4	-0.3	-0.1	0.0	0.5	0.9	-0.8	-1.4	1.3
Angina (self-reported)	0.3	0.4	1.8	-0.1	0.5	0.8	0.8	1.4	-0.6	0.3	-0.5	0.5	0.5	-0.4
Migraine (self-reported)	0.6	0.7	1.9	0.6	-1.0	-0.3	-0.1	-1.0	0.2	-1.4	-0.5	0.7	1.1	-1.2
Medication: Ibuprofen	0.7	0.9	5.8	-0.3	-0.4	0.7	0.6	1.4	-0.5	-2.4	-0.6	0.3	-0.0	0.3
Medication: Allopurinol	2.4	3.2	11.7	-1.3	1.5	-1.5	-1.7	-1.0	0.9	3.4	1.6	-2.1	-1.5	1.9
Medication: Omeprazole	3.0	3.6	7.3	1.5	-1.9	2.4	2.2	1.0	-0.5	-2.0	-2.0	2.1	2.7	-1.7
Medication: Seretide 50 evohaler	0.3	0.3	1.4	-0.2	-0.2	-0.0	0.2	0.8	-1.1	-1.2	-0.3	0.3	-0.1	-0.3
Mean time to correctly identify matches	0.1	0.3	0.7	0.0	-0.4	0.6	0.6	0.6	-0.0	-0.8	-0.7	0.6	0.1	-0.3
Heart disease (mother)	2.7	3.3	9.2	1.5	-0.7	1.3	2.1	1.0	-1.4	-3.0	-2.0	1.9	2.0	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.5	0.2	-0.3	0.5	0.9	1.2	-1.9	-0.7	-0.6	0.3	-0.6	0.2
Whole body fat mass	2.1	8.7	16.3	2.7	-2.7	4.0	3.9	3.5	-2.5	-1.2	-2.4	2.7	3.1	-2.5
Leg fat mass (right)	1.7	6.5	12.3	2.5	-2.5	3.5	3.3	2.5	-1.9	-1.6	-1.9	2.3	3.0	-2.2
Arm predicted mass (right)	0.2	1.1	3.3	1.8	-1.2	1.6	1.3	0.4	0.1	-0.6	0.1	0.7	1.3	-0.6
Pulse rate, automated reading	0.5	1.8	3.8	1.2	-0.9	1.7	1.9	0.5	-0.2	-1.3	-1.1	1.8	1.5	-1.3
Alcohol intake frequency.	0.1	0.3	1.3	-0.5	-0.1	0.7	0.5	1.1	0.1	0.5	0.2	-0.0	-0.4	0.5
Comparative height size at age 10	0.4	2.1	6.7	0.5	-1.3	1.3	1.3	2.0	-2.5	-2.6	-0.6	0.7	0.4	-0.2
Number of full sisters	2.3	2.8	6.3	-2.5	1.8	-1.3	-1.3	-1.1	-0.7	0.3	1.3	-2.0	-2.5	2.1
Suffer from ‘nerves’	0.8	1.2	2.5	0.9	-0.0	0.8	1.2	0.7	-1.2	-1.6	-1.6	1.2	0.2	-1.3
Overall health rating	2.1	4.5	19.8	0.1	-1.5	2.3	2.2	4.4	-2.7	-1.9	-1.7	1.4	0.6	-1.0
Chest pain or discomfort	0.3	0.5	2.1	-1.4	0.3	-0.7	-0.6	0.6	-0.8	0.3	0.5	-0.9	-0.4	0.5
Had major operations	0.1	0.1	0.5	-0.1	0.3	0.2	0.0	-0.7	0.2	-0.1	-0.0	0.3	-0.0	0.0
Age at last live birth	0.6	0.8	2.1	1.0	-0.9	0.3	0.4	-0.2	-0.6	-1.4	-0.6	0.8	1.3	-1.4
Family relationship satisfaction	0.6	0.8	2.6	-1.6	0.9	-0.3	-0.7	-0.7	1.2	1.2	0.3	-0.7	-0.4	0.6
Leg pain on walking	3.4	4.3	9.4	1.1	-0.6	2.2	2.4	3.1	-2.2	-2.3	-2.2	2.5	0.9	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.5	1.0	0.0	0.0	-0.1	-0.6	0.3	1.2	-0.2	0.5	0.8	-0.9
Commuting to job workplace: Car/motor vehicle	5.4	6.2	13.1	2.7	-3.3	2.1	2.5	0.4	-1.2	-1.7	-2.5	2.6	3.6	-2.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.7	-0.6	1.4	-1.4	-1.2	-1.9	1.7	0.7	1.2	-0.6	-0.2	0.1
Medication: Aspirin	0.3	0.4	3.0	-0.4	0.3	0.3	-0.0	0.6	0.4	-1.7	0.1	-0.5	-0.3	0.5
Supplements: Vitamin C	0.7	0.8	2.6	-0.4	1.1	-1.6	-1.1	-0.5	0.0	-0.3	1.2	-1.0	-0.7	0.9
Knee pain experienced in last month	1.3	2.0	4.1	0.7	-1.0	0.9	1.6	-0.8	-0.4	-2.0	-1.3	1.7	1.9	-1.8
Hypertension (Self-reported)	0.1	0.4	1.9	0.3	-0.1	0.5	0.9	-0.3	-0.9	-1.4	-0.5	0.5	0.0	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.5	-0.9	0.7	-0.3	-0.3	-1.2	0.7	0.2	0.1	-0.0	0.8	0.0
Illnesses of father: Heart disease	1.7	2.3	4.6	2.1	-1.6	1.9	1.8	1.1	-1.0	-1.3	-1.4	1.4	1.6	-1.3
Illnesses of siblings: Diabetes	0.4	0.5	2.6	-0.5	-1.1	0.0	0.3	0.8	-0.8	-1.6	-0.2	0.1	0.2	-0.0
Smoking status: Previous	0.3	0.5	1.2	-0.4	1.1	-0.8	-1.1	-1.0	0.1	0.8	0.4	-0.5	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	7.2	2.2	-1.6	2.7	2.4	2.1	-1.7	-0.0	-2.1	1.8	1.5	-1.5
Whole body fat-free mass	0.5	3.0	6.7	2.6	-2.3	2.4	2.0	0.9	-0.2	-0.7	-0.8	1.5	2.3	-1.5
Leg fat-free mass (right)	0.8	4.3	8.7	2.5	-2.8	2.9	2.6	1.8	-0.9	-0.7	-1.4	1.8	2.3	-1.8
Arm fat percentage (left)	2.0	8.1	15.0	2.4	-2.8	3.9	3.8	3.0	-1.9	-0.9	-2.5	2.7	3.4	-2.7
Average weekly red wine intake	1.1	1.6	3.3	1.5	-1.0	1.1	1.4	-1.1	-0.2	0.1	-1.5	1.3	1.8	-1.7
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.2	-0.2	1.4	-1.2	-1.0	-1.6	1.8	0.6	0.7	-0.4	0.4	-0.4
Mood swings	0.4	0.8	2.6	-1.1	0.7	-0.5	-0.9	1.6	-0.2	0.5	0.9	-0.8	-0.9	0.7
Loneliness, isolation	3.0	4.2	9.5	1.2	-1.4	3.1	2.7	1.4	-2.0	-1.7	-2.6	2.4	1.4	-1.6
Long-standing illness, disability or infirmity	5.8	8.9	15.1	2.2	-3.2	3.1	3.4	1.8	-3.1	-3.9	-3.2	3.2	2.4	-2.7
Ever had bowel cancer screening	0.9	1.1	2.3	0.3	-1.5	1.5	1.2	0.1	0.5	-0.8	-1.2	0.9	1.3	-1.1
Diabetes diagnosed by doctor	2.3	3.7	7.5	1.4	-1.3	1.8	2.1	1.8	-2.2	-2.7	-1.8	2.0	2.0	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	0.5	-1.2	0.4	0.6	-1.0	-0.6	-0.2	-0.7	0.4	0.5	-0.4
Friendships satisfaction	0.5	0.6	2.2	-1.5	0.6	-0.6	-0.7	-0.9	1.0	-0.0	0.1	-0.6	-0.2	0.4
Qualifications: nursing, teaching	0.2	0.3	0.9	0.1	0.1	-0.5	-0.1	-0.9	0.7	0.3	-0.1	-0.0	0.7	-0.7
Commuting to job workplace: Walk	1.4	1.5	4.8	-1.8	0.6	-0.8	-1.2	1.0	0.1	0.7	1.0	-1.2	-2.2	1.5
Eye problems/disorders: Cataract	0.6	0.7	2.7	-0.4	0.5	0.4	0.5	0.6	-1.6	-0.1	-0.1	-0.4	-1.5	1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	8.2	0.5	-1.5	1.9	1.0	2.9	1.2	-0.3	-0.6	0.8	0.9	-0.4
Medication for cholesterol	0.3	0.5	1.9	0.2	1.4	-0.6	-0.4	0.2	0.9	1.0	0.2	-0.1	0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.4	0.1	0.4	0.4	0.8	-0.3	-1.6	-1.5	-0.7	0.3	-0.1	0.1
Back pain experienced in last month	0.2	0.3	1.7	0.3	-0.5	0.4	0.3	-0.2	-0.6	-1.3	-0.2	0.3	0.8	-0.4
Mineral and other dietary supplements	0.6	0.9	4.3	0.9	-1.0	0.6	0.6	-0.1	-0.4	-0.1	-0.6	0.7	2.1	-1.4
Breast cancer (self-reported)	1.7	2.1	4.9	1.4	-0.5	0.7	1.0	-0.3	-0.5	-2.2	-1.3	1.7	2.1	-2.1
Asthma (self-reported)	0.4	0.8	1.6	0.4	-1.3	1.2	1.1	1.0	-0.6	-0.9	-0.9	0.7	0.6	-0.3
Osteoporosis (self-reported)	0.3	0.3	1.1	0.2	-0.7	0.7	0.7	0.3	-1.1	-0.8	-0.5	0.3	-0.1	-0.0
Osteoarthritis (self-reported)	2.7	3.5	7.8	1.2	-2.8	1.1	2.0	-0.5	-1.8	-2.3	-1.9	2.2	1.2	-2.2
Medication: Aspirin	0.3	0.4	2.7	-0.4	0.1	0.3	-0.1	0.7	0.2	-1.6	0.3	-0.5	-0.5	0.7
Medication: Gliclazide	0.4	0.5	2.0	0.7	-0.8	0.8	0.6	0.4	-0.4	-1.4	-0.7	0.3	0.7	0.0
Illnesses of father: None of the above (group 1)	2.6	3.2	5.3	-2.1	0.7	-1.7	-2.3	0.5	1.1	1.8	2.1	-2.1	-2.2	2.0
Smoking status: Current	0.6	1.0	2.7	0.8	-0.7	1.6	1.5	0.4	-1.0	-0.6	-1.5	1.0	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	-0.8	0.4	-1.2	-0.9	-1.5	-0.0	-0.7	1.1	-0.9	-1.0	1.3
Whole body water mass	0.5	3.1	6.8	2.6	-2.3	2.5	2.0	0.9	-0.1	-0.8	-0.8	1.5	2.3	-1.5
Leg predicted mass (right)	0.8	4.1	8.5	2.4	-2.7	2.9	2.5	1.9	-0.9	-0.7	-1.3	1.7	2.2	-1.7
Arm fat mass (left)	1.8	7.4	14.3	2.7	-2.9	3.8	3.6	2.6	-1.6	-0.8	-2.1	2.6	3.4	-2.5
Number of self-reported non-cancer illnesses	0.7	1.2	2.9	0.2	-1.3	1.7	1.3	1.7	-1.0	-0.9	-1.1	0.7	0.3	0.0
Average weekly champagne plus white wine intake	0.3	0.5	2.9	-0.2	-0.0	-0.2	0.3	-1.7	0.5	-0.3	0.1	0.3	0.9	-0.9
Miserableness	0.1	0.2	1.1	-0.3	-0.3	0.3	0.1	-0.1	-1.0	0.6	-0.6	0.3	0.3	-0.5
Guilty feelings	0.2	0.3	0.9	-1.0	0.5	-0.6	-0.5	0.4	-0.3	0.4	0.6	-0.4	-0.1	0.4
Wears glasses or contact lenses	0.4	0.4	2.4	-0.3	0.4	-0.6	-0.0	-1.6	-0.2	-1.1	0.2	-0.4	-0.5	0.2
Ever taken oral contraceptive pill	1.3	1.5	4.2	1.3	-2.1	1.2	1.2	0.4	-0.9	-0.7	-1.7	1.3	0.6	-1.1
Hearing aid user	1.4	1.6	7.5	-0.5	0.9	-1.2	-1.1	-0.7	2.7	2.1	0.9	-0.8	-0.4	0.4
Mother’s age at death	1.2	1.4	2.8	1.7	-0.5	1.6	1.7	0.3	-1.3	-1.0	-1.4	1.6	0.2	-0.6
Financial situation satisfaction	0.2	0.2	1.1	-0.4	-0.0	0.3	0.4	-0.7	-0.4	-1.1	-0.1	0.0	-0.3	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.0	0.8	-0.3	1.6	1.3	1.6	-1.7	-1.0	-1.2	1.1	-0.2	-0.1
Commuting to job workplace: Public transport	1.3	1.6	4.6	-0.5	2.2	-1.5	-1.4	-1.3	1.1	1.3	1.2	-1.1	-0.9	0.7
Eye problems/disorders: Glaucoma	2.7	3.1	10.1	-1.7	0.3	-0.1	-0.9	2.2	-0.5	1.5	1.5	-1.8	-2.8	3.2
Medication: Blood pressure	0.5	1.0	3.0	0.8	-0.7	1.0	1.2	0.0	-1.0	-1.7	-1.3	1.1	0.5	-0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.5	0.6	0.5	0.5	0.0	-0.2	0.3	0.1	0.3	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	1.8	2.3	6.5	-1.3	1.6	-1.5	-1.4	-0.5	1.2	0.1	1.4	-1.7	-2.5	2.0
High cholesterol (Self-reported)	0.4	0.8	2.0	-1.0	0.6	-0.4	-0.8	-1.4	0.6	-0.9	0.7	-0.9	-0.6	1.2
Medication: Bendroflumethiazide	0.3	0.4	1.1	-0.7	0.6	-0.5	-0.2	-0.5	1.0	0.6	1.0	-0.7	-0.5	0.6
Medication: Paracetamol	1.2	1.9	6.1	1.2	-2.5	1.6	1.5	1.7	-1.2	-0.4	-1.2	1.3	0.4	-0.9
Medication: Lisinopril	0.4	0.6	1.7	-0.9	-0.7	-0.4	-0.1	0.6	-1.3	-0.8	0.2	-0.5	-1.2	0.5
Medication: Atorvastatin	0.8	1.0	2.4	0.7	-0.4	1.2	0.7	1.6	-0.3	-0.2	-0.7	1.1	1.3	-1.5
Illnesses of father: High blood pressure	1.8	2.2	4.5	1.5	-1.6	2.1	1.8	1.6	-1.6	-0.3	-1.7	1.2	1.0	-0.8
Alcohol drinker status: Never	0.6	0.8	1.4	-1.0	1.0	-1.0	-0.5	-0.9	0.5	0.8	1.1	-0.6	-1.2	0.8
Ever smoked	0.2	0.3	1.3	0.5	1.1	0.2	-0.4	-0.6	0.2	0.7	-0.4	0.2	0.5	-0.7
Basal metabolic rate	0.8	4.2	8.2	2.7	-2.6	2.9	2.5	1.6	-0.8	-0.8	-1.1	1.8	2.5	-1.8
Leg fat percentage (left)	1.4	5.2	9.3	2.0	-1.8	2.9	3.0	2.1	-1.9	-1.4	-1.9	2.3	2.9	-2.2
Arm fat-free mass (left)	0.4	1.9	5.0	2.2	-1.5	1.8	1.6	0.5	0.0	-0.5	-0.3	1.1	2.1	-1.3
Number of operations (self-reported)	2.2	3.2	8.5	1.4	-1.4	1.6	2.1	0.5	-2.0	-2.9	-2.0	2.1	0.9	-1.4
Average weekly beer plus cider intake	0.8	1.1	2.9	1.0	-0.9	0.5	0.9	0.1	-1.3	-1.7	-1.0	1.5	0.7	-1.2
Irritability	0.5	0.9	2.6	0.5	-0.6	0.8	0.9	1.6	-1.4	-0.5	-1.1	0.8	0.6	-0.8
Risk taking	1.1	1.6	4.3	-2.1	1.2	-1.1	-1.5	-0.1	0.5	0.9	1.3	-1.5	-0.7	1.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	-0.2	-0.7	-0.2	-0.3	-0.0	0.6	-0.4	0.4	-0.9	-0.8	0.8
Fractured/broken bones in last 5 years	0.9	1.2	3.5	-1.4	0.8	-1.9	-1.5	-0.3	0.1	-0.1	1.2	-1.4	-0.5	0.8
Age started oral contraceptive pill	0.6	0.7	2.0	1.0	-0.3	0.3	0.1	-1.4	1.4	-0.7	-0.2	0.3	1.3	-0.6
Diastolic blood pressure, automated reading	0.7	2.2	5.0	1.7	-0.6	0.5	1.0	-1.6	1.7	-1.6	-0.8	1.3	2.2	-2.1
Ever depressed for a whole week	0.7	0.9	1.9	0.7	-1.2	0.9	1.2	1.4	-0.5	-0.1	-1.2	1.0	0.3	-0.8
Unable to work because of sickness or disability	1.6	2.0	3.8	0.7	-0.9	1.6	1.7	1.0	-1.5	-2.0	-1.4	1.4	1.6	-1.4
Commuting to job workplace: Cycle	3.8	4.5	7.9	-2.1	1.8	-1.9	-2.3	-0.8	1.9	1.8	2.4	-2.1	-2.8	2.8
Myopia	1.7	2.4	5.1	1.7	-2.2	0.9	1.2	-0.4	-1.1	-0.8	-1.9	1.6	1.7	-2.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.0	-0.2	-0.5	-0.8	0.0	0.5	0.6	0.4	-0.4	-0.4	0.0
Cholesterol lowering medication	0.3	0.5	3.2	0.1	-0.5	-0.2	-0.2	-1.8	0.9	-1.0	0.3	-0.2	-0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	7.9	1.4	-1.5	2.1	2.3	-0.1	-0.7	-2.3	-1.9	2.2	2.8	-1.8
Pain experienced in last month	1.0	1.7	3.7	-1.0	0.9	-1.0	-1.2	-0.9	0.3	1.9	1.0	-1.4	-1.9	1.7
Supplements: Calcium	0.5	0.5	1.3	-0.9	0.8	-0.7	-0.6	0.1	0.4	0.5	0.6	-0.8	-1.2	0.9
Basal cell carcinoma (self-reported)	0.4	0.5	2.0	-0.4	1.0	-0.2	-0.0	0.8	-0.3	-0.0	0.5	-0.5	-1.4	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	-1.3	0.5	0.1	0.1	1.4	-0.6	-1.0	0.2	-0.3	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.2	-0.3	-0.7	-0.0	0.0	-0.7	1.5	-1.2	0.0	0.4	0.8	-0.5
Heart disease (siblings)	2.4	2.9	6.2	1.4	-1.4	2.5	2.0	1.2	-1.9	-2.0	-1.9	1.5	1.2	-1.2
Alcohol drinker status: Previous	0.6	0.7	1.4	0.7	-1.1	1.2	1.1	1.1	0.5	0.7	-0.9	0.7	0.4	-0.5
Pack years of smoking	1.2	1.7	3.2	1.5	-0.7	1.7	1.7	0.8	-1.1	-1.8	-1.3	1.5	0.9	-0.9
Impedance of whole body	0.4	2.3	7.5	-1.6	1.1	-0.3	-0.3	2.7	-2.7	0.4	-0.5	-0.5	-1.9	1.3
Leg fat mass (left)	1.4	5.6	10.1	2.2	-2.2	3.2	3.1	2.4	-2.0	-1.5	-1.7	2.1	2.8	-2.0
Arm predicted mass (left)	0.4	1.9	5.1	2.3	-1.5	1.8	1.6	0.3	0.2	-0.5	-0.2	1.2	2.1	-1.3