Hub : Genes

SLC20A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2170	0.0690	6.8e-06	0.089	NA	0.060	NA	0.123	1.3e-05	NA	3.0e-04	NA	2.7e-07
2	GTEx	Cells Transformed fibroblasts	0.1430	0.0390	5.9e-07	0.107	NA	0.138	NA	0.133	2.0e-08	NA	1.7e-10	NA	3.8e-10
3	GTEx	Lung	0.0601	0.0261	6.7e-03	0.033	NA	0.008	NA	0.001	1.3e-03	NA	7.3e-02	NA	2.9e-01
4	METSIM	Adipose	0.0651	0.0197	1.7e-07	0.061	0.058	0.067	0.060	0.070	1.9e-09	3.9e-09	3.0e-10	2.5e-09	1.3e-10
5	YFS	Blood	0.0465	0.0133	4.7e-13	0.039	0.043	0.039	0.042	0.036	7.2e-13	6.1e-14	1.2e-12	1.4e-13	6.2e-12
6	TCGA	Breast Invasive Carcinoma	0.0114	0.0067	4.7e-03	0.004	0.006	0.001	NA	0.002	4.6e-02	1.8e-02	2.2e-01	NA	1.1e-01
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0323	0.0182	3.1e-03	0.008	0.019	0.011	NA	0.006	4.1e-02	2.6e-03	1.7e-02	NA	6.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	2.8	-1.0	-0.5	0.5	0.2	-0.6	1.7	-0.5
Bipolar Disorder or Schizophrenia	1.1	2.8	7.5	-2.5	-1.2	-0.8	-1.1	-1.4	2.7	-0.3
Depressed Affect (Nagel 2018)	1.9	3.9	6.2	0.8	2.5	1.6	1.7	2.4	-2.2	2.1
Depression (Nagel 2018)	0.9	1.4	2.3	0.6	1.5	1.3	1.0	1.2	-1.4	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	1.2	-0.2	0.1	0.5	0.7	-0.2	0.8
Neuroticism (Nagel 2018)	0.7	1.7	3.4	0.2	1.6	1.0	1.1	1.8	-1.2	1.6
Schizophrenia (2018)	1.2	2.6	6.0	-2.5	-1.1	-1.3	-1.6	-1.4	2.2	-0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.0	0.5	-0.2	-0.2	0.7	-0.6	0.8
Worry (Nagel 2018)	0.1	0.3	0.6	-0.8	-0.5	-0.6	-0.5	0.1	0.8	0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	-0.6	-1.2	-1.1	-1.0	-0.3	0.8	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	1.6	-0.1	-0.9	-0.3	-0.0	0.5	0.7	-1.2
Alzheimer’s Disease (including proxy)	3.1	4.5	7.4	-1.6	-2.7	-2.4	-2.2	-1.2	2.2	-2.1
Crohns Disease (2017)	7.6	16.7	23.6	4.4	3.9	4.5	4.7	3.4	-4.9	2.1
Irritable Bowel Disease (IBD)	6.5	15.6	20.6	4.5	3.7	4.4	4.4	3.3	-4.5	2.0
Ulcerative Colitis (UC)	2.7	5.0	7.1	2.7	2.2	2.5	2.2	2.1	-2.6	1.1
Major Depression (MDD)	1.6	2.0	3.7	1.3	1.9	1.3	1.6	0.6	-1.9	0.6
Reaction Time	0.1	0.1	0.5	0.3	0.1	-0.3	0.1	0.0	-0.5	-0.7
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.2	-0.5	-0.4	-0.3	-0.2	0.4	-0.3
Breast Cancer	0.5	1.1	1.7	1.1	1.3	1.2	0.8	0.7	-1.2	0.9
Ovarian Cancer	0.3	0.4	0.7	0.6	-0.1	-0.2	-0.3	-0.9	-0.9	0.8
Prostate Cancer	0.3	0.5	2.1	0.1	0.8	1.5	0.6	0.1	-0.3	0.3
Age at First Birth	2.6	3.8	6.0	-1.5	-2.1	-2.1	-2.4	-2.4	1.6	-1.3
Bipolar Disorder (2011)	1.4	1.4	4.1	-1.7	-0.9	-0.3	-0.5	-1.1	2.0	-0.6
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-0.9	-0.4	-0.4	-0.3	-1.1	0.2	-1.0
Coronary Artery Disease (CAD)	3.4	4.1	7.2	1.6	2.3	2.5	2.7	1.6	-1.8	1.2
Crohns Disease (2012)	10.9	17.5	21.5	3.3	4.5	4.4	4.6	4.4	-4.5	3.4
Mean Putamen Volume	0.2	0.3	0.8	-0.9	-0.5	-0.1	-0.2	-0.7	0.4	0.4
Fasting Glucose	1.2	1.5	3.2	-1.8	-0.9	-1.1	-1.3	-0.6	1.7	-0.2
HbA1C	9.7	10.8	12.6	3.1	3.6	3.3	3.3	2.9	-3.3	3.4
HDL Cholesterol	0.1	0.1	0.4	-0.3	0.2	0.0	-0.1	0.5	0.1	-0.6
LDL Cholesterol	0.6	0.9	3.1	-1.8	-0.5	-1.0	-1.0	0.3	0.9	0.3
Lupus	1.1	1.7	5.6	2.4	0.8	0.8	1.3	0.4	-1.8	-0.3
Neuroticism (2016)	0.5	0.8	1.8	-1.3	-0.8	-1.1	-1.1	-0.2	0.5	-0.4
Primary Biliary Cirrhosis	1.6	2.3	4.7	1.8	1.5	1.6	1.9	0.0	-2.2	-0.4
Rheumatoid Arthritis	0.3	0.4	1.1	-0.5	0.5	0.6	0.2	1.0	-0.8	0.5
Schizophrenia (2014)	1.0	2.3	6.0	-2.5	-1.0	-1.1	-1.5	-1.1	2.1	-0.0
Triglycerides	0.6	1.0	3.0	0.1	1.1	1.4	0.7	0.5	-0.5	1.7
Type 2 Diabetes (T2D) (2012)	2.2	2.5	4.0	1.1	1.6	1.4	1.9	2.0	-1.8	1.0
Ulcerative Colitis	1.3	1.8	3.3	0.7	1.8	1.8	1.2	1.1	-1.5	0.9
Blood Eosinophil Count	1.7	13.0	17.7	2.1	4.0	4.2	3.8	3.5	-3.0	4.2
Blood Platelet Count	0.5	5.7	10.4	-3.2	-2.2	-2.0	-2.6	-1.6	2.6	-2.1
Blood Red Count	10.0	97.0	169.0	-11.6	-10.2	-8.4	-9.1	-7.7	13.0	-7.7
Blood White Count	0.7	5.2	11.4	-3.4	-2.0	-0.8	-2.1	-1.9	2.8	-2.0
Heel T-Score	0.3	2.2	4.5	-0.6	1.7	1.4	1.5	2.1	-1.0	1.7
BMI	0.1	0.8	2.1	-1.2	1.5	0.5	0.4	-0.5	-0.2	1.0
Height	0.2	3.1	4.9	-1.2	-2.1	-1.9	-1.6	-2.2	1.3	-1.7
Waist Hip Ratio (WHR)	0.1	0.4	2.1	-1.4	-0.1	-0.5	-0.3	-0.1	0.5	0.4
Systolic Blood Pressure	2.7	13.3	39.0	6.2	3.0	3.5	3.8	1.6	-2.8	2.9
Smoking Status	3.1	7.4	11.9	2.1	3.4	3.5	2.7	2.4	-2.5	2.2
Allergy or Eczema	0.2	0.5	0.8	0.5	0.9	0.8	0.3	0.9	-0.9	0.5
Cardiovascular Disease	1.2	3.9	6.2	2.5	2.2	1.9	2.0	1.5	-1.8	1.9
Hypothyroidism (self reported)	0.3	0.6	1.0	0.5	0.8	0.3	0.8	0.7	-1.0	1.0
Respiratory disease	0.8	1.8	4.1	2.0	1.4	1.3	1.5	0.1	-1.6	0.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.5	1.2	1.9	1.3	1.5	1.2	-1.5	0.8
Lung FEV1/FVC ratio	0.2	0.9	3.9	-2.0	0.0	-0.2	-0.6	1.1	0.5	0.8
Lung FVC	0.3	1.3	2.7	1.6	1.0	0.8	0.7	1.3	-1.5	0.7
Neuroticism	0.3	0.7	2.3	-0.9	1.0	0.2	0.0	1.5	-0.4	0.9
Chronotype (morning person)	0.9	2.2	5.4	1.1	1.7	1.1	1.1	2.3	-1.1	1.5
Hair Pigment	0.2	5.2	12.6	-0.5	-2.5	-1.8	-1.5	-3.2	1.4	-3.5
Tanning	0.1	0.8	1.8	0.2	0.8	0.8	0.8	1.1	-0.6	1.4
Hand grip strength (left)	2.3	6.2	7.9	2.0	2.8	2.6	2.6	2.4	-2.4	2.5
Number of treatments/medications taken	0.5	0.9	1.9	0.6	1.3	0.6	0.9	0.7	-1.4	0.6
Average weekly spirits intake	2.4	3.0	5.1	1.5	2.3	1.9	1.4	1.1	-1.8	2.0
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.2	0.8	0.3	0.4	0.6	-0.4	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.6	0.2	1.3	1.0	0.7	1.2	-1.3	0.4
Hearing difficulty/problems: Yes	1.4	2.1	7.4	-2.7	-0.7	-0.9	-1.6	-0.4	1.8	-0.1
Relative age of first facial hair	0.6	1.2	3.6	-1.0	-1.0	-0.7	-1.0	-0.5	1.0	-1.9
Other serious medical condition/disability diagnosed by doctor	2.9	3.8	8.3	1.9	2.2	1.8	2.1	1.4	-2.9	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	-1.3	-0.2	-0.0	-0.6	-0.1	1.1	0.4
Ever had hysterectomy (womb removed)	1.6	1.8	5.6	-2.4	-0.8	-1.2	-1.4	-1.2	1.1	-0.6
Systolic blood pressure, automated reading	2.4	7.0	20.2	4.5	2.2	2.4	2.7	1.0	-2.2	2.2
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.1	0.9	1.5	1.5	0.9	1.1	-1.1	0.6
Angina	0.7	1.0	2.2	0.1	1.2	1.5	1.0	0.9	-1.1	0.2
Medication for hormone replacement therapy	5.3	6.0	7.8	2.8	2.4	2.2	2.5	1.9	-2.7	2.5
Vitamin and mineral supplements	0.1	0.1	0.3	0.3	0.4	0.3	0.4	0.6	-0.4	0.1
Supplements: Zinc	0.1	0.1	0.5	-0.5	-0.2	-0.1	-0.2	-0.7	0.4	0.0
Medication: Co-codamol	1.7	2.0	3.4	0.8	1.8	1.3	1.3	1.5	-1.7	1.2
Medication: Metformin	1.5	2.1	3.4	1.9	1.6	1.7	1.7	-0.2	-1.5	0.7
Diabetes (father)	1.9	2.4	3.0	-1.7	-1.6	-1.6	-1.6	-1.4	1.7	-1.2
Diabetes (mother)	1.2	1.5	4.3	2.1	0.9	0.7	1.1	0.4	-1.4	1.2
Severe depression (siblings)	1.3	1.5	4.9	1.6	-0.9	-0.4	-0.1	-2.2	0.0	-1.4
Pack years adult smoking proportion	1.5	2.3	4.2	1.3	2.1	1.8	1.8	-0.1	-1.4	1.2
Impedance of leg (right)	2.2	10.8	16.8	4.1	2.4	3.2	3.6	3.7	-3.3	2.3
Leg fat-free mass (left)	0.3	1.8	7.1	-1.8	-0.2	-0.9	-1.0	-2.7	0.8	-0.4
Trunk fat percentage	1.3	5.2	10.8	1.2	3.3	2.7	2.5	0.9	-2.6	1.7
Hand grip strength (right)	2.4	6.5	8.6	1.5	2.9	2.8	2.7	2.7	-2.2	2.8
Townsend deprivation index at recruitment	3.8	5.4	6.6	2.6	2.5	2.5	2.3	1.9	-2.4	1.9
Current tobacco smoking	2.5	4.2	7.1	1.3	2.6	2.7	2.3	1.6	-2.0	1.3
Average weekly fortified wine intake	0.2	0.2	0.8	-0.9	-0.2	-0.4	-0.6	-0.2	0.3	-0.4
Maternal smoking around birth	3.6	5.2	11.6	1.1	3.4	2.6	2.6	1.3	-2.2	1.8
Fed-up feelings	1.9	3.4	6.4	1.1	2.5	1.5	1.6	1.6	-2.2	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	-0.1	1.1	1.0	0.7	1.0	-0.8	0.5
Relative age voice broke	0.6	0.8	1.3	-1.1	-0.9	-1.2	-1.1	0.3	0.5	-1.0
Taking other prescription medications	0.1	0.2	0.5	-0.3	0.0	-0.5	-0.1	-0.7	-0.2	-0.6
Age when periods started (menarche)	2.5	6.1	8.9	-2.0	-2.9	-3.0	-2.5	-1.6	2.5	-2.6
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.5	-1.1	-0.8	-0.6	-1.0	-1.9	1.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.6	1.1	1.4	1.4	1.4	1.9	-1.1	1.7
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	6.6	-0.9	-1.4	-1.5	-1.0	-0.9	0.9	-2.6
Qualifications: CSEs or equivalent	0.5	0.6	1.8	1.3	0.6	0.8	0.9	0.0	-0.7	0.7
Serious illness, injury or assault to yourself	1.2	1.4	3.4	1.8	1.2	0.7	1.0	0.1	-1.8	0.8
High blood pressure	0.3	0.8	2.0	1.4	1.1	0.9	0.9	0.5	-0.8	0.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.4	1.6	1.4	1.1	0.8	1.1	-1.5	1.5
Multivitamins +/- minerals	0.3	0.4	0.6	-0.7	-0.6	-0.7	-0.8	-0.4	0.7	-0.4
Stomach or abdominal pain in last month	0.3	0.4	1.5	1.2	0.3	-0.0	0.7	0.0	-0.7	0.3
Supplements: Glucosamine	0.6	0.8	2.4	-1.0	-0.6	-0.6	-0.5	-0.4	0.9	-1.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.1	0.3	1.0	1.2	0.9	1.5	-0.9	1.1
Medication: Atenolol	0.7	0.8	2.5	0.6	0.8	0.6	0.6	1.6	-0.9	1.0
Medication: Levothyroxine sodium	0.4	0.7	1.2	-0.1	1.1	0.8	0.9	1.1	-0.5	0.8
Sitting height	0.2	1.1	2.4	1.6	0.8	0.8	1.2	0.3	-1.0	1.1
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	-0.4	0.5	0.1	-0.3	0.4	-0.7	-0.0
High blood pressure (mother)	1.3	1.9	3.7	-0.6	-1.4	-1.8	-1.3	-1.9	1.2	-1.0
Body mass index (BMI)	0.2	0.9	2.7	-0.4	1.6	1.1	0.7	-1.0	-0.7	0.6
Impedance of leg (left)	2.0	9.8	14.4	3.8	2.4	3.1	3.4	3.5	-3.1	2.2
Leg predicted mass (left)	0.4	2.0	7.5	-1.8	-0.2	-0.9	-1.0	-2.7	0.9	-0.5
Trunk fat mass	0.8	3.4	7.8	0.8	2.8	2.3	2.0	0.1	-2.0	1.4
Waist circumference	0.2	0.7	1.6	-1.2	1.1	0.4	0.1	-1.2	-0.3	0.5
Number of incorrect matches in round	0.2	0.3	1.7	-0.1	-0.1	-0.4	-0.3	-0.7	0.1	-1.3
Past tobacco smoking	1.5	2.8	5.8	-0.3	-2.4	-2.1	-1.1	-1.9	1.0	-1.8
Alcohol usually taken with meals	6.3	10.2	15.0	-2.7	-3.9	-3.4	-3.0	-2.8	3.2	-3.3
Nervous feelings	0.3	0.6	1.8	-0.1	-0.8	-0.9	-0.7	-0.5	0.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.4	0.6	1.3	0.7	0.7	1.5	-1.3	0.4
Hearing difficulty/problems with background noise	0.7	1.2	3.1	-0.0	1.2	0.6	0.6	1.8	-0.8	1.5
Hair/balding pattern: Pattern 2	1.0	1.3	2.6	1.6	0.5	0.8	0.8	1.5	-0.6	1.6
Had menopause	1.0	1.3	3.0	-1.7	-0.8	-0.7	-1.1	-1.0	1.5	-0.1
Had other major operations	0.5	0.6	3.1	0.3	0.3	-0.0	0.2	-0.8	-0.5	-1.7
Forced vital capacity (FVC)	0.1	0.5	1.8	1.0	-0.8	-0.3	-0.5	-1.3	0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.8	0.5	0.8	0.7	0.7	1.7	-0.3	1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.9	1.2	0.9	0.7	1.4	-1.0	-0.4	-0.3
Qualifications: None of the above	3.6	7.6	11.5	2.8	3.3	2.9	3.1	1.2	-3.4	2.0
Financial difficulties in last 2 years	0.1	0.2	0.3	0.1	0.6	0.4	0.4	0.4	-0.5	0.3
Mouth/teeth dental problems	1.1	1.7	2.6	0.1	-1.6	-1.1	-1.1	-1.6	1.4	-1.6
Heart attack	1.0	1.3	2.2	0.7	1.3	1.0	1.2	0.9	-1.5	1.0
Allergy	0.7	1.6	2.9	-1.5	-1.7	-1.2	-0.9	-0.4	1.5	-1.0
Pain all over the body in last month	0.2	0.2	0.6	-0.2	0.7	0.8	0.4	-0.5	0.0	0.2
Diabetes (self-reported)	0.4	0.7	1.2	0.9	0.9	0.7	1.1	0.9	-0.8	-0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	1.0	0.6	0.8	0.2	0.2	-1.0	1.1
Medication: Ramipril	0.4	0.5	1.1	1.1	0.3	0.5	0.4	1.0	-1.1	-0.2
Medication: Simvastatin	0.4	0.6	0.8	-0.9	-0.7	-0.8	-0.8	-0.7	0.3	-0.8
Fluid intelligence score	1.0	2.1	4.6	-0.3	-2.1	-1.9	-1.5	-1.2	1.3	-1.2
Illnesses of siblings	0.8	1.1	1.8	0.7	0.9	1.4	1.2	1.3	-0.1	1.2
Neuroticism score	0.6	1.3	3.0	-0.1	1.5	1.0	0.8	1.7	-0.9	1.1
Weight	0.2	0.8	1.9	-0.3	1.3	0.9	0.6	-1.4	-0.7	0.6
Impedance of arm (right)	0.7	3.2	5.8	1.8	1.4	1.6	2.1	2.4	-1.9	0.6
Arm fat percentage (right)	0.6	2.2	6.0	0.1	2.5	1.9	1.6	0.0	-1.6	0.8
Trunk fat-free mass	0.4	2.1	7.0	-1.4	-0.9	-1.1	-1.3	-2.6	1.2	-0.7
Hip circumference	0.2	0.8	2.0	-0.5	1.4	0.8	0.2	-1.2	-0.7	0.9
Time employed in main current job	0.1	0.2	0.6	0.1	0.0	0.5	0.8	-0.4	0.0	0.4
Alcohol intake versus 10 years previously	2.2	3.4	5.3	1.7	1.8	2.0	2.3	1.8	-2.0	1.1
Father’s age at death	1.3	1.8	3.0	-1.7	-1.4	-1.5	-1.6	-0.5	1.0	-1.2
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	-0.4	-0.5	-0.6	-0.2	0.6	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	-0.2	1.5	1.0	0.5	0.5	-1.0	1.1
Falls in the last year	0.1	0.1	0.3	-0.0	0.5	0.3	0.5	0.1	-0.5	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.7	0.6	0.7	0.5	-0.2	-0.0	-0.6
Number of live births	0.1	0.2	0.5	-0.7	-0.2	-0.3	-0.3	-0.4	0.1	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.6	0.1	-1.3	-1.0	-0.9	-1.0	0.4	-0.7
Pulse rate	1.3	2.2	5.6	-1.6	-0.9	-0.6	-1.3	-2.4	1.6	-1.3
Happiness	0.1	0.1	0.3	-0.4	-0.3	-0.1	-0.1	-0.4	0.6	0.1
Noisy workplace	2.3	2.8	4.1	1.6	1.9	1.7	1.7	1.3	-2.0	1.4
Qualifications: A levels/AS levels or equivalent	1.2	2.7	5.2	-0.8	-2.3	-2.0	-1.8	-0.9	1.4	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.8	0.4	1.3	1.2	1.3	0.8	-1.1	1.0
Mouth/teeth dental problems: Dentures	1.1	1.9	4.9	0.6	1.5	1.1	1.1	1.6	-2.2	0.8
Asthma	1.2	2.4	5.1	2.3	1.5	1.4	1.7	0.5	-1.9	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.8	0.2	1.7	0.9	1.0	0.8	-1.0	1.3
Medication: Cholesterol lowering	0.1	0.2	0.9	-0.2	0.1	-0.1	0.0	0.9	-0.7	-0.3
Depression (self-reported)	1.2	1.4	4.0	-2.0	-0.8	-1.3	-1.0	-0.1	1.5	-0.6
Medication: Lansoprazole	0.1	0.1	0.3	-0.2	-0.1	-0.3	-0.2	-0.3	0.2	-0.6
Prospective memory result	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.3	-0.3	0.0	-0.0
Lung cancer (father)	1.0	1.2	2.1	1.2	0.9	0.8	1.0	0.4	-1.4	1.4
Illnesses of mother	1.6	2.0	3.6	0.8	1.4	1.9	1.5	1.2	-1.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.1	-0.4	-0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	0.9	0.5	0.6	0.9	0.5	-0.3	1.1
Impedance of arm (left)	0.5	2.1	4.6	1.5	1.1	1.3	1.6	2.1	-1.6	0.5
Arm fat mass (right)	0.4	1.6	4.8	-0.2	2.2	1.5	1.2	-0.5	-1.3	0.7
Trunk predicted mass	0.3	2.0	6.7	-1.4	-0.8	-1.1	-1.3	-2.6	1.2	-0.7
Standing height	0.0	0.3	1.4	-0.1	-0.6	-0.4	-0.2	-1.2	0.2	-0.2
Length of working week for main job	0.1	0.1	0.2	-0.2	-0.0	0.4	0.3	-0.5	0.3	-0.2
Exposure to tobacco smoke at home	0.2	0.3	1.7	-0.1	0.2	0.1	0.1	-0.1	0.0	-1.3
Breastfed as a baby	0.7	0.9	2.1	-1.4	-0.7	-1.0	-1.0	-0.3	1.0	-0.8
Tense / ‘highly strung’	0.7	1.2	3.2	-1.8	-0.7	-1.2	-1.4	0.5	0.8	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	0.5	0.4	-0.1	-0.0	0.8	-0.4	0.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	-0.0	-0.8	-1.0	-0.7	-0.3	0.3	-1.2
Birth weight of first child	0.5	1.0	3.7	-1.9	-1.0	-0.7	-1.2	0.0	0.5	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.2	-0.8	-0.8	-0.7	0.6	-0.2	-0.4
Pulse wave reflection index	1.3	1.6	3.1	1.8	0.8	0.9	1.4	1.5	-1.1	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	0.7	0.6	0.8	1.4	-0.4	-0.5	-0.5
Loud music exposure frequency	0.3	0.3	1.0	-0.4	-0.4	-1.0	-0.6	-0.2	-0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.9	0.9	-0.1	0.1	0.0	-0.1	-0.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.3	-1.2	0.7	0.4	0.3	1.5	0.6	1.5
Blood clot in the leg (DVT)	4.1	5.3	6.3	-2.4	-2.0	-2.5	-2.5	-2.0	2.4	-2.2
Medication: Paracetamol	0.7	1.1	2.3	0.0	-0.8	-1.4	-1.1	-1.5	0.1	-1.1
Headache pain in last month	0.2	0.3	1.1	0.6	-0.1	-0.1	0.6	1.0	-0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.7	-1.3	-0.6	-0.3	-0.6	-0.7	0.9	-0.4
Glaucoma (self-reported)	1.3	1.6	4.2	0.9	1.3	1.3	0.8	0.6	-1.4	2.1
Gout (self-reported)	0.3	0.4	1.4	-1.2	0.1	0.5	-0.0	0.7	0.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.6	-0.1	-0.7	-0.4	0.1	-0.1	0.2
Medication: Amlodipine	1.5	2.2	5.1	0.1	2.0	1.8	1.0	1.0	-0.8	2.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	1.3	0.5	0.7	0.7	0.2	-0.4	0.4
Birth weight	0.1	0.2	0.5	-0.1	-0.6	-0.2	-0.7	-0.7	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.1	0.7	1.1	0.5	0.6	0.6	-0.6	1.4
High blood pressure (siblings)	0.2	0.3	0.8	-0.4	-0.5	-0.9	-0.7	-0.4	0.1	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.2	0.8	0.9	0.2	0.2	0.2	-0.2	-0.5	-0.0
Body fat percentage	1.1	4.3	8.8	1.1	3.0	2.6	2.3	0.6	-2.3	1.5
Leg fat percentage (right)	1.3	4.7	8.8	1.2	3.0	2.9	2.5	0.8	-2.3	1.6
Arm fat-free mass (right)	0.3	1.4	5.9	-1.1	-0.4	-0.7	-0.9	-2.4	1.0	-0.1
Exposure to tobacco smoke outside home	3.0	4.0	6.7	1.7	2.4	1.9	2.2	1.9	-2.6	0.6
Comparative body size at age 10	0.5	1.3	3.8	0.7	1.6	1.0	0.9	-0.4	-0.7	2.0
Number of full brothers	1.1	1.4	2.8	1.3	1.2	0.8	1.0	1.0	-1.7	1.2
Worry too long after embarrassment	0.4	0.7	1.4	-0.3	-1.2	-1.0	-0.6	-0.0	1.2	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	-1.3	0.1	-0.2	-0.5	0.1	0.8	0.6
Wheeze or whistling in the chest in last year	6.2	11.1	15.8	2.5	4.0	3.9	3.6	3.0	-3.5	2.4
Number of children fathered	0.3	0.3	1.1	-0.8	-0.4	-0.1	-0.5	0.1	0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	8.0	-2.0	-1.9	-1.9	-2.2	-1.8	2.8	-1.3
Age at first live birth	0.8	1.4	2.8	-0.9	-1.7	-1.6	-1.3	-0.3	0.9	-0.9
Pulse wave peak to peak time	0.5	0.5	1.0	-0.8	-0.6	-0.7	-0.9	-0.7	0.2	-1.0
Health satisfaction	0.4	0.6	1.5	1.0	0.3	0.1	0.8	0.1	-0.9	-1.2
Shortness of breath walking on level ground	2.2	2.6	4.9	1.4	1.9	2.2	2.2	0.2	-1.6	0.7
Qualifications: College or University degree	5.1	16.2	22.8	-3.6	-4.8	-4.4	-4.5	-2.4	4.6	-3.3
Eye problems/disorders: None of the above	4.5	5.2	7.8	-2.0	-2.5	-2.4	-2.3	-1.6	2.3	-2.8
Mouth/teeth dental problems: Loose teeth	4.4	5.2	7.5	0.9	2.6	2.4	2.1	2.7	-2.2	2.6
Emphysema/chronic bronchitis	0.7	0.8	2.0	0.7	1.4	1.1	1.1	0.3	-0.6	0.7
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	0.3	-0.6	-0.0	-0.1	0.8	0.1	0.0
Neck or shoulder pain in last month	1.2	1.8	2.9	1.3	1.6	1.5	1.5	0.9	-1.7	0.2
Medication: Blood pressure	0.1	0.2	0.3	0.5	0.5	-0.1	0.0	0.4	-0.4	0.6
Angina (self-reported)	0.9	1.2	2.6	0.3	1.3	1.6	1.1	1.0	-1.3	0.5
Migraine (self-reported)	0.2	0.3	0.6	-0.5	-0.7	-0.4	0.1	0.4	0.5	-0.8
Medication: Ibuprofen	0.7	0.8	2.0	0.2	1.4	0.6	0.9	0.7	-1.1	0.9
Medication: Allopurinol	1.0	1.3	3.2	-1.8	-0.9	-0.9	-1.6	-0.0	1.2	0.3
Medication: Omeprazole	0.6	0.7	2.4	0.3	0.6	0.7	0.7	0.4	-1.6	-0.8
Medication: Seretide 50 evohaler	1.3	1.5	3.4	1.4	1.6	0.9	1.1	0.4	-1.8	0.6
Mean time to correctly identify matches	0.1	0.3	0.7	-0.1	-0.5	-0.7	-0.5	0.0	-0.1	-0.9
Heart disease (mother)	0.5	0.6	2.8	-0.4	-0.5	-0.9	-0.2	0.0	0.1	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.8	0.6	0.9	1.1	1.1	1.0	-1.3	0.4
Whole body fat mass	0.6	2.7	6.5	0.6	2.5	2.0	1.8	-0.2	-1.8	1.1
Leg fat mass (right)	0.7	2.8	6.5	0.5	2.5	2.1	1.8	-0.1	-1.7	1.5
Arm predicted mass (right)	0.2	1.1	5.2	-1.1	-0.2	-0.4	-0.8	-2.3	0.8	0.1
Pulse rate, automated reading	0.1	0.4	0.9	0.6	0.9	0.9	0.9	-0.1	-0.4	-0.1
Alcohol intake frequency.	0.2	0.5	1.2	-0.2	-1.1	-0.7	-0.2	-0.9	0.3	-0.8
Comparative height size at age 10	0.9	4.9	8.2	2.0	2.6	2.1	2.3	1.1	-2.9	2.0
Number of full sisters	1.1	1.3	3.4	0.3	1.1	0.8	0.9	1.4	-1.0	1.9
Suffer from ‘nerves’	0.2	0.3	0.9	-0.2	0.5	0.6	1.0	0.4	-0.1	-0.4
Overall health rating	2.7	5.7	10.2	1.5	3.1	2.4	2.5	1.8	-3.2	1.7
Chest pain or discomfort	2.0	2.9	6.0	1.5	1.7	1.2	1.4	1.8	-2.4	1.4
Had major operations	0.3	0.3	0.9	0.6	0.5	1.0	0.6	0.5	-0.3	0.5
Age at last live birth	0.4	0.6	1.3	0.1	-1.1	-1.2	-0.5	0.0	0.3	-1.1
Family relationship satisfaction	0.1	0.1	0.3	-0.5	0.3	0.2	0.1	0.5	0.1	0.6
Leg pain on walking	0.8	1.0	2.3	0.7	1.2	1.4	1.5	0.3	-0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.5	-0.7	-1.2	-0.7	-1.0	-0.9	1.2	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.4	-0.4	0.0	-0.5	-0.2	-0.5	-0.0	-1.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	-0.8	-1.3	-0.9	-0.9	0.3	1.4	-1.0
Medication: Aspirin	0.9	1.2	1.9	0.8	1.4	1.1	1.2	0.2	-1.0	1.4
Supplements: Vitamin C	0.3	0.3	1.1	0.5	0.3	0.7	0.4	0.2	-0.4	1.1
Knee pain experienced in last month	0.2	0.2	0.6	0.1	0.8	0.3	0.7	-0.0	-0.6	-0.4
Hypertension (Self-reported)	0.4	1.1	2.2	1.3	1.5	1.2	1.1	0.6	-0.8	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.5	-1.2	-0.2	0.0	-0.2	0.0	0.2	-0.2
Illnesses of father: Heart disease	0.4	0.5	1.1	0.3	1.1	0.9	0.9	0.3	-0.7	0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.4	0.2	-0.2	-1.2	-0.3	0.0	-0.9	-0.2
Smoking status: Previous	0.5	0.7	2.2	-0.3	1.1	0.8	0.1	1.5	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	-0.1	-0.0	-0.3	-0.0	-0.7	0.2	-0.6
Whole body fat-free mass	0.4	2.2	7.8	-1.7	-0.7	-1.1	-1.3	-2.8	1.2	-0.6
Leg fat-free mass (right)	0.5	2.7	8.7	-2.1	-0.5	-1.3	-1.4	-2.9	1.2	-0.8
Arm fat percentage (left)	0.5	1.9	5.6	-0.0	2.4	1.8	1.4	-0.2	-1.4	0.8
Average weekly red wine intake	0.1	0.2	0.4	-0.5	0.4	0.6	0.2	0.4	0.1	-0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	-0.3	-0.1	-0.0	-0.4	0.5	-0.2
Mood swings	1.7	3.2	5.5	0.6	2.0	1.6	1.5	2.4	-1.5	2.3
Loneliness, isolation	0.8	1.1	2.6	0.2	1.6	0.8	1.1	1.4	-1.2	0.1
Long-standing illness, disability or infirmity	2.8	4.3	7.8	1.6	2.6	2.2	2.6	1.3	-2.8	0.0
Ever had bowel cancer screening	1.2	1.5	2.8	-0.4	-1.2	-1.6	-1.4	-1.1	0.4	-1.7
Diabetes diagnosed by doctor	2.6	4.2	6.5	2.6	2.2	2.1	2.5	1.4	-2.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.2	-0.6	-0.7	-0.5	-0.8	0.4	-0.8
Friendships satisfaction	0.6	0.7	2.4	-1.5	-0.6	-1.0	-0.7	0.4	0.8	-0.2
Qualifications: nursing, teaching	4.0	6.3	9.2	-2.4	-3.0	-3.0	-2.5	-1.1	2.7	-2.4
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.4	0.1	0.2	0.4
Eye problems/disorders: Cataract	2.7	3.1	3.8	1.7	1.7	1.9	1.8	1.6	-1.9	1.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	-1.0	-1.1	-1.3	-0.8	-1.7	1.3	-0.7
Medication for cholesterol	0.8	1.2	3.0	-1.7	-1.1	-1.2	-1.0	0.0	1.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	2.8	1.0	1.5	1.5	1.7	1.4	-1.3	0.7
Back pain experienced in last month	3.4	5.0	8.1	1.7	2.8	2.2	2.4	2.1	-2.0	2.3
Mineral and other dietary supplements	0.4	0.6	1.2	0.9	0.9	0.6	0.6	0.5	-1.1	0.5
Breast cancer (self-reported)	0.4	0.5	2.5	-0.3	-0.4	-0.3	-0.2	-0.7	0.5	-1.6
Asthma (self-reported)	0.6	1.1	2.7	1.6	1.1	1.0	1.1	-0.1	-1.3	0.4
Osteoporosis (self-reported)	0.3	0.4	1.9	1.4	0.1	0.1	0.6	0.2	-0.5	-0.1
Osteoarthritis (self-reported)	0.9	1.1	5.9	-0.3	-0.6	-0.9	-0.6	-0.5	-0.2	-2.4
Medication: Aspirin	1.5	1.9	3.0	1.1	1.7	1.4	1.5	0.5	-1.4	1.7
Medication: Gliclazide	0.2	0.2	0.4	0.7	-0.6	-0.5	0.0	-0.4	0.2	-0.4
Illnesses of father: None of the above (group 1)	0.7	0.8	4.1	0.7	0.3	0.1	0.5	0.7	-0.6	2.0
Smoking status: Current	1.9	3.1	6.1	0.9	2.2	2.5	2.0	1.3	-1.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.5	-0.2	-0.2	0.2	0.8	-0.5	0.4
Whole body water mass	0.4	2.3	8.2	-1.7	-0.7	-1.1	-1.3	-2.9	1.2	-0.7
Leg predicted mass (right)	0.5	2.5	8.4	-2.1	-0.4	-1.2	-1.3	-2.9	1.1	-0.7
Arm fat mass (left)	0.3	1.4	4.3	-0.3	2.1	1.5	1.0	-0.8	-1.1	0.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.8	0.9	0.8	0.4	0.4	0.4	-0.8	0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.5	-0.6	-0.5	-0.7	-0.6	-0.4	0.3	-0.7
Miserableness	1.8	3.1	7.8	0.7	2.0	1.6	1.3	2.8	-1.9	1.2
Guilty feelings	3.1	4.6	6.3	1.4	2.4	2.2	1.8	2.5	-2.5	2.1
Wears glasses or contact lenses	0.3	0.4	1.0	-1.0	-0.3	-0.9	-0.7	0.1	0.4	-0.0
Ever taken oral contraceptive pill	0.3	0.3	0.5	0.7	0.2	-0.2	-0.2	-0.6	-0.7	-0.7
Hearing aid user	5.8	6.5	10.4	-2.7	-2.6	-2.1	-2.4	-3.0	3.2	-1.7
Mother’s age at death	0.5	0.6	2.8	-0.4	-1.0	-0.4	-0.3	0.1	0.2	-1.7
Financial situation satisfaction	0.3	0.3	1.2	1.1	0.0	-0.1	0.4	0.7	-0.7	-0.1
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.3	1.8	0.9	1.3	1.3	0.9	-1.8	0.3
Commuting to job workplace: Public transport	0.3	0.3	1.2	-0.6	-0.4	0.2	-0.1	0.1	1.1	0.6
Eye problems/disorders: Glaucoma	0.9	1.0	4.6	-0.1	1.1	0.9	0.1	-0.1	-0.7	2.1
Medication: Blood pressure	0.2	0.4	1.0	0.5	0.7	1.0	0.8	-0.4	-0.2	-0.6
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.0	0.4	1.4	1.2	1.0	1.0	-1.0	0.9
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.9	-1.7	-1.4	-1.4	-1.5	-0.9	1.5	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.3	0.5	-0.0	0.0	0.7	-0.6	0.5
Medication: Bendroflumethiazide	0.1	0.1	0.5	0.3	-0.1	-0.3	-0.3	-0.7	0.3	0.2
Medication: Paracetamol	0.8	1.3	2.0	-0.5	-1.0	-1.4	-1.3	-1.4	0.5	-1.4
Medication: Lisinopril	0.1	0.1	0.4	-0.1	-0.3	-0.6	-0.3	0.3	-0.1	-0.1
Medication: Atorvastatin	0.2	0.3	0.6	0.2	0.5	0.4	0.5	0.8	-0.4	-0.6
Illnesses of father: High blood pressure	0.7	0.9	1.5	1.2	1.0	1.2	1.1	0.1	-1.1	0.1
Alcohol drinker status: Never	1.4	1.7	5.5	-2.3	-1.3	-0.9	-0.8	-0.5	1.7	-0.6
Ever smoked	1.3	2.2	4.4	0.2	2.1	1.9	0.9	2.0	-0.7	1.5
Basal metabolic rate	0.2	1.3	5.9	-1.3	-0.1	-0.5	-0.7	-2.4	0.6	-0.3
Leg fat percentage (left)	1.3	4.6	8.9	1.1	3.0	2.8	2.4	0.7	-2.2	1.6
Arm fat-free mass (left)	0.2	1.1	5.1	-1.2	-0.2	-0.5	-0.7	-2.3	0.8	-0.1
Number of operations (self-reported)	0.2	0.3	1.0	-0.5	1.0	0.8	0.5	0.1	-0.4	-0.3
Average weekly beer plus cider intake	1.9	2.7	5.1	0.8	2.3	2.1	1.9	1.4	-1.7	0.7
Irritability	1.8	3.0	5.7	-0.5	2.4	1.8	1.2	2.4	-1.9	1.1
Risk taking	1.7	2.4	6.4	0.4	1.6	1.4	1.1	1.5	-1.5	2.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	-0.4	-1.5	-1.8	-1.4	-1.3	0.9	-0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.6	-1.3	-0.6	-0.9	-0.6	0.2	0.7	0.0
Age started oral contraceptive pill	2.6	3.2	4.6	-1.3	-2.1	-2.1	-1.9	-1.8	1.6	-1.7
Diastolic blood pressure, automated reading	0.4	1.3	3.2	-0.3	-0.9	-0.6	-0.4	-1.8	1.3	-1.7
Ever depressed for a whole week	0.2	0.2	0.8	0.2	0.6	0.2	0.3	-0.9	-0.2	0.0
Unable to work because of sickness or disability	4.0	5.2	7.5	1.9	2.7	2.5	2.5	1.8	-2.7	1.5
Commuting to job workplace: Cycle	2.5	3.0	5.1	-1.7	-2.3	-2.2	-2.0	-1.1	1.8	-0.3
Myopia	1.7	2.5	4.1	-1.2	-1.6	-1.9	-1.8	-1.1	1.2	-2.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.4	-1.2	-0.9	-0.7	-0.6	-0.4	0.6	-0.2
Cholesterol lowering medication	0.2	0.4	0.6	-0.6	-0.3	-0.6	-0.7	-0.8	0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-0.1	0.8	0.7	0.5	0.6	-1.1	-0.8
Pain experienced in last month	0.8	1.4	2.4	-1.4	-1.5	-1.1	-1.6	-0.6	1.1	-0.5
Supplements: Calcium	0.0	0.0	0.1	0.2	-0.2	0.0	0.1	0.2	0.1	-0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	0.5	1.0	0.8	1.0	0.7	-1.1	0.7
Deep venous thrombosis (DVT) (self-reported)	5.9	7.5	9.2	-2.8	-2.5	-3.0	-3.0	-2.3	2.8	-2.7
Heart disease (siblings)	3.2	3.9	5.7	1.4	2.4	2.2	2.2	1.8	-2.3	1.4
Alcohol drinker status: Previous	1.1	1.3	4.1	0.2	-1.1	-0.9	-0.9	-2.0	0.5	-1.3
Pack years of smoking	0.7	1.0	2.2	0.7	1.5	1.2	1.2	-0.4	-1.0	0.7
Impedance of whole body	1.3	6.8	10.0	3.0	2.0	2.5	2.9	3.2	-2.7	1.6
Leg fat mass (left)	0.7	2.9	6.7	0.5	2.6	2.2	1.9	-0.0	-1.7	1.5
Arm predicted mass (left)	0.2	1.3	5.6	-1.2	-0.3	-0.6	-0.8	-2.4	0.9	-0.2