Hub : Genes

SLC20A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2170 0.0690 6.8e-06 0.089 NA 0.060 NA 0.123 1.3e-05 NA 3.0e-04 NA 2.7e-07
2 GTEx Cells Transformed fibroblasts 0.1430 0.0390 5.9e-07 0.107 NA 0.138 NA 0.133 2.0e-08 NA 1.7e-10 NA 3.8e-10
3 GTEx Lung 0.0601 0.0261 6.7e-03 0.033 NA 0.008 NA 0.001 1.3e-03 NA 7.3e-02 NA 2.9e-01
4 METSIM Adipose 0.0651 0.0197 1.7e-07 0.061 0.058 0.067 0.060 0.070 1.9e-09 3.9e-09 3.0e-10 2.5e-09 1.3e-10
5 YFS Blood 0.0465 0.0133 4.7e-13 0.039 0.043 0.039 0.042 0.036 7.2e-13 6.1e-14 1.2e-12 1.4e-13 6.2e-12
6 TCGA Breast Invasive Carcinoma 0.0114 0.0067 4.7e-03 0.004 0.006 0.001 NA 0.002 4.6e-02 1.8e-02 2.2e-01 NA 1.1e-01
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0323 0.0182 3.1e-03 0.008 0.019 0.011 NA 0.006 4.1e-02 2.6e-03 1.7e-02 NA 6.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.7 2.8 -1.0 -0.5 0.5 0.2 -0.6 1.7 -0.5
Bipolar Disorder or Schizophrenia 1.1 2.8 7.5 -2.5 -1.2 -0.8 -1.1 -1.4 2.7 -0.3
Depressed Affect (Nagel 2018) 1.9 3.9 6.2 0.8 2.5 1.6 1.7 2.4 -2.2 2.1
Depression (Nagel 2018) 0.9 1.4 2.3 0.6 1.5 1.3 1.0 1.2 -1.4 0.7
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.5 1.2 -0.2 0.1 0.5 0.7 -0.2 0.8
Neuroticism (Nagel 2018) 0.7 1.7 3.4 0.2 1.6 1.0 1.1 1.8 -1.2 1.6
Schizophrenia (2018) 1.2 2.6 6.0 -2.5 -1.1 -1.3 -1.6 -1.4 2.2 -0.0
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 -0.0 0.5 -0.2 -0.2 0.7 -0.6 0.8
Worry (Nagel 2018) 0.1 0.3 0.6 -0.8 -0.5 -0.6 -0.5 0.1 0.8 0.2
Alzheimer’s Disease (in mother) 0.6 0.7 1.4 -0.6 -1.2 -1.1 -1.0 -0.3 0.8 -0.5
Alzheimer’s Disease (in father) 0.4 0.4 1.6 -0.1 -0.9 -0.3 -0.0 0.5 0.7 -1.2
Alzheimer’s Disease (including proxy) 3.1 4.5 7.4 -1.6 -2.7 -2.4 -2.2 -1.2 2.2 -2.1
Crohns Disease (2017) 7.6 16.7 23.6 4.4 3.9 4.5 4.7 3.4 -4.9 2.1
Irritable Bowel Disease (IBD) 6.5 15.6 20.6 4.5 3.7 4.4 4.4 3.3 -4.5 2.0
Ulcerative Colitis (UC) 2.7 5.0 7.1 2.7 2.2 2.5 2.2 2.1 -2.6 1.1
Major Depression (MDD) 1.6 2.0 3.7 1.3 1.9 1.3 1.6 0.6 -1.9 0.6
Reaction Time 0.1 0.1 0.5 0.3 0.1 -0.3 0.1 0.0 -0.5 -0.7
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 0.2 -0.5 -0.4 -0.3 -0.2 0.4 -0.3
Breast Cancer 0.5 1.1 1.7 1.1 1.3 1.2 0.8 0.7 -1.2 0.9
Ovarian Cancer 0.3 0.4 0.7 0.6 -0.1 -0.2 -0.3 -0.9 -0.9 0.8
Prostate Cancer 0.3 0.5 2.1 0.1 0.8 1.5 0.6 0.1 -0.3 0.3
Age at First Birth 2.6 3.8 6.0 -1.5 -2.1 -2.1 -2.4 -2.4 1.6 -1.3
Bipolar Disorder (2011) 1.4 1.4 4.1 -1.7 -0.9 -0.3 -0.5 -1.1 2.0 -0.6
Body Mass Index (BMI) (2010) 0.4 0.5 1.2 -0.9 -0.4 -0.4 -0.3 -1.1 0.2 -1.0
Coronary Artery Disease (CAD) 3.4 4.1 7.2 1.6 2.3 2.5 2.7 1.6 -1.8 1.2
Crohns Disease (2012) 10.9 17.5 21.5 3.3 4.5 4.4 4.6 4.4 -4.5 3.4
Mean Putamen Volume 0.2 0.3 0.8 -0.9 -0.5 -0.1 -0.2 -0.7 0.4 0.4
Fasting Glucose 1.2 1.5 3.2 -1.8 -0.9 -1.1 -1.3 -0.6 1.7 -0.2
HbA1C 9.7 10.8 12.6 3.1 3.6 3.3 3.3 2.9 -3.3 3.4
HDL Cholesterol 0.1 0.1 0.4 -0.3 0.2 0.0 -0.1 0.5 0.1 -0.6
LDL Cholesterol 0.6 0.9 3.1 -1.8 -0.5 -1.0 -1.0 0.3 0.9 0.3
Lupus 1.1 1.7 5.6 2.4 0.8 0.8 1.3 0.4 -1.8 -0.3
Neuroticism (2016) 0.5 0.8 1.8 -1.3 -0.8 -1.1 -1.1 -0.2 0.5 -0.4
Primary Biliary Cirrhosis 1.6 2.3 4.7 1.8 1.5 1.6 1.9 0.0 -2.2 -0.4
Rheumatoid Arthritis 0.3 0.4 1.1 -0.5 0.5 0.6 0.2 1.0 -0.8 0.5
Schizophrenia (2014) 1.0 2.3 6.0 -2.5 -1.0 -1.1 -1.5 -1.1 2.1 -0.0
Triglycerides 0.6 1.0 3.0 0.1 1.1 1.4 0.7 0.5 -0.5 1.7
Type 2 Diabetes (T2D) (2012) 2.2 2.5 4.0 1.1 1.6 1.4 1.9 2.0 -1.8 1.0
Ulcerative Colitis 1.3 1.8 3.3 0.7 1.8 1.8 1.2 1.1 -1.5 0.9
Blood Eosinophil Count 1.7 13.0 17.7 2.1 4.0 4.2 3.8 3.5 -3.0 4.2
Blood Platelet Count 0.5 5.7 10.4 -3.2 -2.2 -2.0 -2.6 -1.6 2.6 -2.1
Blood Red Count 10.0 97.0 169.0 -11.6 -10.2 -8.4 -9.1 -7.7 13.0 -7.7
Blood White Count 0.7 5.2 11.4 -3.4 -2.0 -0.8 -2.1 -1.9 2.8 -2.0
Heel T-Score 0.3 2.2 4.5 -0.6 1.7 1.4 1.5 2.1 -1.0 1.7
BMI 0.1 0.8 2.1 -1.2 1.5 0.5 0.4 -0.5 -0.2 1.0
Height 0.2 3.1 4.9 -1.2 -2.1 -1.9 -1.6 -2.2 1.3 -1.7
Waist Hip Ratio (WHR) 0.1 0.4 2.1 -1.4 -0.1 -0.5 -0.3 -0.1 0.5 0.4
Systolic Blood Pressure 2.7 13.3 39.0 6.2 3.0 3.5 3.8 1.6 -2.8 2.9
Smoking Status 3.1 7.4 11.9 2.1 3.4 3.5 2.7 2.4 -2.5 2.2
Allergy or Eczema 0.2 0.5 0.8 0.5 0.9 0.8 0.3 0.9 -0.9 0.5
Cardiovascular Disease 1.2 3.9 6.2 2.5 2.2 1.9 2.0 1.5 -1.8 1.9
Hypothyroidism (self reported) 0.3 0.6 1.0 0.5 0.8 0.3 0.8 0.7 -1.0 1.0
Respiratory disease 0.8 1.8 4.1 2.0 1.4 1.3 1.5 0.1 -1.6 0.1
Type 2 Diabetes (T2D) (2018) 1.0 1.9 3.5 1.2 1.9 1.3 1.5 1.2 -1.5 0.8
Lung FEV1/FVC ratio 0.2 0.9 3.9 -2.0 0.0 -0.2 -0.6 1.1 0.5 0.8
Lung FVC 0.3 1.3 2.7 1.6 1.0 0.8 0.7 1.3 -1.5 0.7
Neuroticism 0.3 0.7 2.3 -0.9 1.0 0.2 0.0 1.5 -0.4 0.9
Chronotype (morning person) 0.9 2.2 5.4 1.1 1.7 1.1 1.1 2.3 -1.1 1.5
Hair Pigment 0.2 5.2 12.6 -0.5 -2.5 -1.8 -1.5 -3.2 1.4 -3.5
Tanning 0.1 0.8 1.8 0.2 0.8 0.8 0.8 1.1 -0.6 1.4
Hand grip strength (left) 2.3 6.2 7.9 2.0 2.8 2.6 2.6 2.4 -2.4 2.5
Number of treatments/medications taken 0.5 0.9 1.9 0.6 1.3 0.6 0.9 0.7 -1.4 0.6
Average weekly spirits intake 2.4 3.0 5.1 1.5 2.3 1.9 1.4 1.1 -1.8 2.0
Sensitivity / hurt feelings 0.1 0.2 0.6 -0.2 0.8 0.3 0.4 0.6 -0.4 0.5
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.6 0.2 1.3 1.0 0.7 1.2 -1.3 0.4
Hearing difficulty/problems: Yes 1.4 2.1 7.4 -2.7 -0.7 -0.9 -1.6 -0.4 1.8 -0.1
Relative age of first facial hair 0.6 1.2 3.6 -1.0 -1.0 -0.7 -1.0 -0.5 1.0 -1.9
Other serious medical condition/disability diagnosed by doctor 2.9 3.8 8.3 1.9 2.2 1.8 2.1 1.4 -2.9 -0.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.6 -1.3 -0.2 -0.0 -0.6 -0.1 1.1 0.4
Ever had hysterectomy (womb removed) 1.6 1.8 5.6 -2.4 -0.8 -1.2 -1.4 -1.2 1.1 -0.6
Systolic blood pressure, automated reading 2.4 7.0 20.2 4.5 2.2 2.4 2.7 1.0 -2.2 2.2
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.1 0.9 1.5 1.5 0.9 1.1 -1.1 0.6
Angina 0.7 1.0 2.2 0.1 1.2 1.5 1.0 0.9 -1.1 0.2
Medication for hormone replacement therapy 5.3 6.0 7.8 2.8 2.4 2.2 2.5 1.9 -2.7 2.5
Vitamin and mineral supplements 0.1 0.1 0.3 0.3 0.4 0.3 0.4 0.6 -0.4 0.1
Supplements: Zinc 0.1 0.1 0.5 -0.5 -0.2 -0.1 -0.2 -0.7 0.4 0.0
Medication: Co-codamol 1.7 2.0 3.4 0.8 1.8 1.3 1.3 1.5 -1.7 1.2
Medication: Metformin 1.5 2.1 3.4 1.9 1.6 1.7 1.7 -0.2 -1.5 0.7
Diabetes (father) 1.9 2.4 3.0 -1.7 -1.6 -1.6 -1.6 -1.4 1.7 -1.2
Diabetes (mother) 1.2 1.5 4.3 2.1 0.9 0.7 1.1 0.4 -1.4 1.2
Severe depression (siblings) 1.3 1.5 4.9 1.6 -0.9 -0.4 -0.1 -2.2 0.0 -1.4
Pack years adult smoking proportion 1.5 2.3 4.2 1.3 2.1 1.8 1.8 -0.1 -1.4 1.2
Impedance of leg (right) 2.2 10.8 16.8 4.1 2.4 3.2 3.6 3.7 -3.3 2.3
Leg fat-free mass (left) 0.3 1.8 7.1 -1.8 -0.2 -0.9 -1.0 -2.7 0.8 -0.4
Trunk fat percentage 1.3 5.2 10.8 1.2 3.3 2.7 2.5 0.9 -2.6 1.7
Hand grip strength (right) 2.4 6.5 8.6 1.5 2.9 2.8 2.7 2.7 -2.2 2.8
Townsend deprivation index at recruitment 3.8 5.4 6.6 2.6 2.5 2.5 2.3 1.9 -2.4 1.9
Current tobacco smoking 2.5 4.2 7.1 1.3 2.6 2.7 2.3 1.6 -2.0 1.3
Average weekly fortified wine intake 0.2 0.2 0.8 -0.9 -0.2 -0.4 -0.6 -0.2 0.3 -0.4
Maternal smoking around birth 3.6 5.2 11.6 1.1 3.4 2.6 2.6 1.3 -2.2 1.8
Fed-up feelings 1.9 3.4 6.4 1.1 2.5 1.5 1.6 1.6 -2.2 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.3 -0.1 1.1 1.0 0.7 1.0 -0.8 0.5
Relative age voice broke 0.6 0.8 1.3 -1.1 -0.9 -1.2 -1.1 0.3 0.5 -1.0
Taking other prescription medications 0.1 0.2 0.5 -0.3 0.0 -0.5 -0.1 -0.7 -0.2 -0.6
Age when periods started (menarche) 2.5 6.1 8.9 -2.0 -2.9 -3.0 -2.5 -1.6 2.5 -2.6
Bilateral oophorectomy (both ovaries removed) 1.2 1.3 3.5 -1.1 -0.8 -0.6 -1.0 -1.9 1.2 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 3.6 1.1 1.4 1.4 1.4 1.9 -1.1 1.7
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 6.6 -0.9 -1.4 -1.5 -1.0 -0.9 0.9 -2.6
Qualifications: CSEs or equivalent 0.5 0.6 1.8 1.3 0.6 0.8 0.9 0.0 -0.7 0.7
Serious illness, injury or assault to yourself 1.2 1.4 3.4 1.8 1.2 0.7 1.0 0.1 -1.8 0.8
High blood pressure 0.3 0.8 2.0 1.4 1.1 0.9 0.9 0.5 -0.8 0.2
Hayfever, allergic rhinitis or eczema 0.8 1.7 2.4 1.6 1.4 1.1 0.8 1.1 -1.5 1.5
Multivitamins +/- minerals 0.3 0.4 0.6 -0.7 -0.6 -0.7 -0.8 -0.4 0.7 -0.4
Stomach or abdominal pain in last month 0.3 0.4 1.5 1.2 0.3 -0.0 0.7 0.0 -0.7 0.3
Supplements: Glucosamine 0.6 0.8 2.4 -1.0 -0.6 -0.6 -0.5 -0.4 0.9 -1.5
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.1 0.3 1.0 1.2 0.9 1.5 -0.9 1.1
Medication: Atenolol 0.7 0.8 2.5 0.6 0.8 0.6 0.6 1.6 -0.9 1.0
Medication: Levothyroxine sodium 0.4 0.7 1.2 -0.1 1.1 0.8 0.9 1.1 -0.5 0.8
Sitting height 0.2 1.1 2.4 1.6 0.8 0.8 1.2 0.3 -1.0 1.1
Chronic bronchitis/emphysema (father) 0.1 0.2 0.5 -0.4 0.5 0.1 -0.3 0.4 -0.7 -0.0
High blood pressure (mother) 1.3 1.9 3.7 -0.6 -1.4 -1.8 -1.3 -1.9 1.2 -1.0
Body mass index (BMI) 0.2 0.9 2.7 -0.4 1.6 1.1 0.7 -1.0 -0.7 0.6
Impedance of leg (left) 2.0 9.8 14.4 3.8 2.4 3.1 3.4 3.5 -3.1 2.2
Leg predicted mass (left) 0.4 2.0 7.5 -1.8 -0.2 -0.9 -1.0 -2.7 0.9 -0.5
Trunk fat mass 0.8 3.4 7.8 0.8 2.8 2.3 2.0 0.1 -2.0 1.4
Waist circumference 0.2 0.7 1.6 -1.2 1.1 0.4 0.1 -1.2 -0.3 0.5
Number of incorrect matches in round 0.2 0.3 1.7 -0.1 -0.1 -0.4 -0.3 -0.7 0.1 -1.3
Past tobacco smoking 1.5 2.8 5.8 -0.3 -2.4 -2.1 -1.1 -1.9 1.0 -1.8
Alcohol usually taken with meals 6.3 10.2 15.0 -2.7 -3.9 -3.4 -3.0 -2.8 3.2 -3.3
Nervous feelings 0.3 0.6 1.8 -0.1 -0.8 -0.9 -0.7 -0.5 0.6 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 2.4 0.6 1.3 0.7 0.7 1.5 -1.3 0.4
Hearing difficulty/problems with background noise 0.7 1.2 3.1 -0.0 1.2 0.6 0.6 1.8 -0.8 1.5
Hair/balding pattern: Pattern 2 1.0 1.3 2.6 1.6 0.5 0.8 0.8 1.5 -0.6 1.6
Had menopause 1.0 1.3 3.0 -1.7 -0.8 -0.7 -1.1 -1.0 1.5 -0.1
Had other major operations 0.5 0.6 3.1 0.3 0.3 -0.0 0.2 -0.8 -0.5 -1.7
Forced vital capacity (FVC) 0.1 0.5 1.8 1.0 -0.8 -0.3 -0.5 -1.3 0.1 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.8 0.5 0.8 0.7 0.7 1.7 -0.3 1.5
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.9 1.2 0.9 0.7 1.4 -1.0 -0.4 -0.3
Qualifications: None of the above 3.6 7.6 11.5 2.8 3.3 2.9 3.1 1.2 -3.4 2.0
Financial difficulties in last 2 years 0.1 0.2 0.3 0.1 0.6 0.4 0.4 0.4 -0.5 0.3
Mouth/teeth dental problems 1.1 1.7 2.6 0.1 -1.6 -1.1 -1.1 -1.6 1.4 -1.6
Heart attack 1.0 1.3 2.2 0.7 1.3 1.0 1.2 0.9 -1.5 1.0
Allergy 0.7 1.6 2.9 -1.5 -1.7 -1.2 -0.9 -0.4 1.5 -1.0
Pain all over the body in last month 0.2 0.2 0.6 -0.2 0.7 0.8 0.4 -0.5 0.0 0.2
Diabetes (self-reported) 0.4 0.7 1.2 0.9 0.9 0.7 1.1 0.9 -0.8 -0.0
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.3 1.0 0.6 0.8 0.2 0.2 -1.0 1.1
Medication: Ramipril 0.4 0.5 1.1 1.1 0.3 0.5 0.4 1.0 -1.1 -0.2
Medication: Simvastatin 0.4 0.6 0.8 -0.9 -0.7 -0.8 -0.8 -0.7 0.3 -0.8
Fluid intelligence score 1.0 2.1 4.6 -0.3 -2.1 -1.9 -1.5 -1.2 1.3 -1.2
Illnesses of siblings 0.8 1.1 1.8 0.7 0.9 1.4 1.2 1.3 -0.1 1.2
Neuroticism score 0.6 1.3 3.0 -0.1 1.5 1.0 0.8 1.7 -0.9 1.1
Weight 0.2 0.8 1.9 -0.3 1.3 0.9 0.6 -1.4 -0.7 0.6
Impedance of arm (right) 0.7 3.2 5.8 1.8 1.4 1.6 2.1 2.4 -1.9 0.6
Arm fat percentage (right) 0.6 2.2 6.0 0.1 2.5 1.9 1.6 0.0 -1.6 0.8
Trunk fat-free mass 0.4 2.1 7.0 -1.4 -0.9 -1.1 -1.3 -2.6 1.2 -0.7
Hip circumference 0.2 0.8 2.0 -0.5 1.4 0.8 0.2 -1.2 -0.7 0.9
Time employed in main current job 0.1 0.2 0.6 0.1 0.0 0.5 0.8 -0.4 0.0 0.4
Alcohol intake versus 10 years previously 2.2 3.4 5.3 1.7 1.8 2.0 2.3 1.8 -2.0 1.1
Father’s age at death 1.3 1.8 3.0 -1.7 -1.4 -1.5 -1.6 -0.5 1.0 -1.2
Worrier / anxious feelings 0.1 0.2 0.4 -0.6 -0.4 -0.5 -0.6 -0.2 0.6 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.1 -0.2 1.5 1.0 0.5 0.5 -1.0 1.1
Falls in the last year 0.1 0.1 0.3 -0.0 0.5 0.3 0.5 0.1 -0.5 0.2
Hair/balding pattern: Pattern 3 0.2 0.3 0.5 -0.7 0.6 0.7 0.5 -0.2 -0.0 -0.6
Number of live births 0.1 0.2 0.5 -0.7 -0.2 -0.3 -0.3 -0.4 0.1 -0.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.6 0.1 -1.3 -1.0 -0.9 -1.0 0.4 -0.7
Pulse rate 1.3 2.2 5.6 -1.6 -0.9 -0.6 -1.3 -2.4 1.6 -1.3
Happiness 0.1 0.1 0.3 -0.4 -0.3 -0.1 -0.1 -0.4 0.6 0.1
Noisy workplace 2.3 2.8 4.1 1.6 1.9 1.7 1.7 1.3 -2.0 1.4
Qualifications: A levels/AS levels or equivalent 1.2 2.7 5.2 -0.8 -2.3 -2.0 -1.8 -0.9 1.4 -1.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.8 0.4 1.3 1.2 1.3 0.8 -1.1 1.0
Mouth/teeth dental problems: Dentures 1.1 1.9 4.9 0.6 1.5 1.1 1.1 1.6 -2.2 0.8
Asthma 1.2 2.4 5.1 2.3 1.5 1.4 1.7 0.5 -1.9 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.8 0.2 1.7 0.9 1.0 0.8 -1.0 1.3
Medication: Cholesterol lowering 0.1 0.2 0.9 -0.2 0.1 -0.1 0.0 0.9 -0.7 -0.3
Depression (self-reported) 1.2 1.4 4.0 -2.0 -0.8 -1.3 -1.0 -0.1 1.5 -0.6
Medication: Lansoprazole 0.1 0.1 0.3 -0.2 -0.1 -0.3 -0.2 -0.3 0.2 -0.6
Prospective memory result 0.0 0.0 0.1 0.3 -0.0 -0.1 -0.3 -0.3 0.0 -0.0
Lung cancer (father) 1.0 1.2 2.1 1.2 0.9 0.8 1.0 0.4 -1.4 1.4
Illnesses of mother 1.6 2.0 3.6 0.8 1.4 1.9 1.5 1.2 -1.1 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.1 0.2 -0.1 -0.1 -0.1 -0.1 -0.4 -0.1
Pulse wave Arterial Stiffness index 0.4 0.5 1.1 0.9 0.5 0.6 0.9 0.5 -0.3 1.1
Impedance of arm (left) 0.5 2.1 4.6 1.5 1.1 1.3 1.6 2.1 -1.6 0.5
Arm fat mass (right) 0.4 1.6 4.8 -0.2 2.2 1.5 1.2 -0.5 -1.3 0.7
Trunk predicted mass 0.3 2.0 6.7 -1.4 -0.8 -1.1 -1.3 -2.6 1.2 -0.7
Standing height 0.0 0.3 1.4 -0.1 -0.6 -0.4 -0.2 -1.2 0.2 -0.2
Length of working week for main job 0.1 0.1 0.2 -0.2 -0.0 0.4 0.3 -0.5 0.3 -0.2
Exposure to tobacco smoke at home 0.2 0.3 1.7 -0.1 0.2 0.1 0.1 -0.1 0.0 -1.3
Breastfed as a baby 0.7 0.9 2.1 -1.4 -0.7 -1.0 -1.0 -0.3 1.0 -0.8
Tense / ‘highly strung’ 0.7 1.2 3.2 -1.8 -0.7 -1.2 -1.4 0.5 0.8 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 0.5 0.4 -0.1 -0.0 0.8 -0.4 0.0
Hair/balding pattern: Pattern 4 0.2 0.5 1.4 -0.0 -0.8 -1.0 -0.7 -0.3 0.3 -1.2
Birth weight of first child 0.5 1.0 3.7 -1.9 -1.0 -0.7 -1.2 0.0 0.5 0.3
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.2 -0.8 -0.8 -0.7 0.6 -0.2 -0.4
Pulse wave reflection index 1.3 1.6 3.1 1.8 0.8 0.9 1.4 1.5 -1.1 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.0 0.7 0.6 0.8 1.4 -0.4 -0.5 -0.5
Loud music exposure frequency 0.3 0.3 1.0 -0.4 -0.4 -1.0 -0.6 -0.2 -0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.9 0.9 -0.1 0.1 0.0 -0.1 -0.4 0.4
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.3 -1.2 0.7 0.4 0.3 1.5 0.6 1.5
Blood clot in the leg (DVT) 4.1 5.3 6.3 -2.4 -2.0 -2.5 -2.5 -2.0 2.4 -2.2
Medication: Paracetamol 0.7 1.1 2.3 0.0 -0.8 -1.4 -1.1 -1.5 0.1 -1.1
Headache pain in last month 0.2 0.3 1.1 0.6 -0.1 -0.1 0.6 1.0 -0.4 0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.7 -1.3 -0.6 -0.3 -0.6 -0.7 0.9 -0.4
Glaucoma (self-reported) 1.3 1.6 4.2 0.9 1.3 1.3 0.8 0.6 -1.4 2.1
Gout (self-reported) 0.3 0.4 1.4 -1.2 0.1 0.5 -0.0 0.7 0.3 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 -0.6 -0.1 -0.7 -0.4 0.1 -0.1 0.2
Medication: Amlodipine 1.5 2.2 5.1 0.1 2.0 1.8 1.0 1.0 -0.8 2.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 1.3 0.5 0.7 0.7 0.2 -0.4 0.4
Birth weight 0.1 0.2 0.5 -0.1 -0.6 -0.2 -0.7 -0.7 0.3 -0.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.1 0.7 1.1 0.5 0.6 0.6 -0.6 1.4
High blood pressure (siblings) 0.2 0.3 0.8 -0.4 -0.5 -0.9 -0.7 -0.4 0.1 -0.1
Forced vital capacity (FVC), Best measure 0.0 0.2 0.8 0.9 0.2 0.2 0.2 -0.2 -0.5 -0.0
Body fat percentage 1.1 4.3 8.8 1.1 3.0 2.6 2.3 0.6 -2.3 1.5
Leg fat percentage (right) 1.3 4.7 8.8 1.2 3.0 2.9 2.5 0.8 -2.3 1.6
Arm fat-free mass (right) 0.3 1.4 5.9 -1.1 -0.4 -0.7 -0.9 -2.4 1.0 -0.1
Exposure to tobacco smoke outside home 3.0 4.0 6.7 1.7 2.4 1.9 2.2 1.9 -2.6 0.6
Comparative body size at age 10 0.5 1.3 3.8 0.7 1.6 1.0 0.9 -0.4 -0.7 2.0
Number of full brothers 1.1 1.4 2.8 1.3 1.2 0.8 1.0 1.0 -1.7 1.2
Worry too long after embarrassment 0.4 0.7 1.4 -0.3 -1.2 -1.0 -0.6 -0.0 1.2 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.7 -1.3 0.1 -0.2 -0.5 0.1 0.8 0.6
Wheeze or whistling in the chest in last year 6.2 11.1 15.8 2.5 4.0 3.9 3.6 3.0 -3.5 2.4
Number of children fathered 0.3 0.3 1.1 -0.8 -0.4 -0.1 -0.5 0.1 0.5 1.1
Reason for reducing amount of alcohol drunk: Health precaution 3.5 4.1 8.0 -2.0 -1.9 -1.9 -2.2 -1.8 2.8 -1.3
Age at first live birth 0.8 1.4 2.8 -0.9 -1.7 -1.6 -1.3 -0.3 0.9 -0.9
Pulse wave peak to peak time 0.5 0.5 1.0 -0.8 -0.6 -0.7 -0.9 -0.7 0.2 -1.0
Health satisfaction 0.4 0.6 1.5 1.0 0.3 0.1 0.8 0.1 -0.9 -1.2
Shortness of breath walking on level ground 2.2 2.6 4.9 1.4 1.9 2.2 2.2 0.2 -1.6 0.7
Qualifications: College or University degree 5.1 16.2 22.8 -3.6 -4.8 -4.4 -4.5 -2.4 4.6 -3.3
Eye problems/disorders: None of the above 4.5 5.2 7.8 -2.0 -2.5 -2.4 -2.3 -1.6 2.3 -2.8
Mouth/teeth dental problems: Loose teeth 4.4 5.2 7.5 0.9 2.6 2.4 2.1 2.7 -2.2 2.6
Emphysema/chronic bronchitis 0.7 0.8 2.0 0.7 1.4 1.1 1.1 0.3 -0.6 0.7
Medication for pain relief, constipation, heartburn 0.1 0.2 0.7 0.3 -0.6 -0.0 -0.1 0.8 0.1 0.0
Neck or shoulder pain in last month 1.2 1.8 2.9 1.3 1.6 1.5 1.5 0.9 -1.7 0.2
Medication: Blood pressure 0.1 0.2 0.3 0.5 0.5 -0.1 0.0 0.4 -0.4 0.6
Angina (self-reported) 0.9 1.2 2.6 0.3 1.3 1.6 1.1 1.0 -1.3 0.5
Migraine (self-reported) 0.2 0.3 0.6 -0.5 -0.7 -0.4 0.1 0.4 0.5 -0.8
Medication: Ibuprofen 0.7 0.8 2.0 0.2 1.4 0.6 0.9 0.7 -1.1 0.9
Medication: Allopurinol 1.0 1.3 3.2 -1.8 -0.9 -0.9 -1.6 -0.0 1.2 0.3
Medication: Omeprazole 0.6 0.7 2.4 0.3 0.6 0.7 0.7 0.4 -1.6 -0.8
Medication: Seretide 50 evohaler 1.3 1.5 3.4 1.4 1.6 0.9 1.1 0.4 -1.8 0.6
Mean time to correctly identify matches 0.1 0.3 0.7 -0.1 -0.5 -0.7 -0.5 0.0 -0.1 -0.9
Heart disease (mother) 0.5 0.6 2.8 -0.4 -0.5 -0.9 -0.2 0.0 0.1 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.8 0.6 0.9 1.1 1.1 1.0 -1.3 0.4
Whole body fat mass 0.6 2.7 6.5 0.6 2.5 2.0 1.8 -0.2 -1.8 1.1
Leg fat mass (right) 0.7 2.8 6.5 0.5 2.5 2.1 1.8 -0.1 -1.7 1.5
Arm predicted mass (right) 0.2 1.1 5.2 -1.1 -0.2 -0.4 -0.8 -2.3 0.8 0.1
Pulse rate, automated reading 0.1 0.4 0.9 0.6 0.9 0.9 0.9 -0.1 -0.4 -0.1
Alcohol intake frequency. 0.2 0.5 1.2 -0.2 -1.1 -0.7 -0.2 -0.9 0.3 -0.8
Comparative height size at age 10 0.9 4.9 8.2 2.0 2.6 2.1 2.3 1.1 -2.9 2.0
Number of full sisters 1.1 1.3 3.4 0.3 1.1 0.8 0.9 1.4 -1.0 1.9
Suffer from ‘nerves’ 0.2 0.3 0.9 -0.2 0.5 0.6 1.0 0.4 -0.1 -0.4
Overall health rating 2.7 5.7 10.2 1.5 3.1 2.4 2.5 1.8 -3.2 1.7
Chest pain or discomfort 2.0 2.9 6.0 1.5 1.7 1.2 1.4 1.8 -2.4 1.4
Had major operations 0.3 0.3 0.9 0.6 0.5 1.0 0.6 0.5 -0.3 0.5
Age at last live birth 0.4 0.6 1.3 0.1 -1.1 -1.2 -0.5 0.0 0.3 -1.1
Family relationship satisfaction 0.1 0.1 0.3 -0.5 0.3 0.2 0.1 0.5 0.1 0.6
Leg pain on walking 0.8 1.0 2.3 0.7 1.2 1.4 1.5 0.3 -0.7 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.5 -0.7 -1.2 -0.7 -1.0 -0.9 1.2 -0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.4 2.4 -0.4 0.0 -0.5 -0.2 -0.5 -0.0 -1.6
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.9 -0.8 -1.3 -0.9 -0.9 0.3 1.4 -1.0
Medication: Aspirin 0.9 1.2 1.9 0.8 1.4 1.1 1.2 0.2 -1.0 1.4
Supplements: Vitamin C 0.3 0.3 1.1 0.5 0.3 0.7 0.4 0.2 -0.4 1.1
Knee pain experienced in last month 0.2 0.2 0.6 0.1 0.8 0.3 0.7 -0.0 -0.6 -0.4
Hypertension (Self-reported) 0.4 1.1 2.2 1.3 1.5 1.2 1.1 0.6 -0.8 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 1.5 -1.2 -0.2 0.0 -0.2 0.0 0.2 -0.2
Illnesses of father: Heart disease 0.4 0.5 1.1 0.3 1.1 0.9 0.9 0.3 -0.7 0.4
Illnesses of siblings: Diabetes 0.3 0.4 1.4 0.2 -0.2 -1.2 -0.3 0.0 -0.9 -0.2
Smoking status: Previous 0.5 0.7 2.2 -0.3 1.1 0.8 0.1 1.5 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.4 -0.1 -0.0 -0.3 -0.0 -0.7 0.2 -0.6
Whole body fat-free mass 0.4 2.2 7.8 -1.7 -0.7 -1.1 -1.3 -2.8 1.2 -0.6
Leg fat-free mass (right) 0.5 2.7 8.7 -2.1 -0.5 -1.3 -1.4 -2.9 1.2 -0.8
Arm fat percentage (left) 0.5 1.9 5.6 -0.0 2.4 1.8 1.4 -0.2 -1.4 0.8
Average weekly red wine intake 0.1 0.2 0.4 -0.5 0.4 0.6 0.2 0.4 0.1 -0.6
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.2 -0.3 -0.1 -0.0 -0.4 0.5 -0.2
Mood swings 1.7 3.2 5.5 0.6 2.0 1.6 1.5 2.4 -1.5 2.3
Loneliness, isolation 0.8 1.1 2.6 0.2 1.6 0.8 1.1 1.4 -1.2 0.1
Long-standing illness, disability or infirmity 2.8 4.3 7.8 1.6 2.6 2.2 2.6 1.3 -2.8 0.0
Ever had bowel cancer screening 1.2 1.5 2.8 -0.4 -1.2 -1.6 -1.4 -1.1 0.4 -1.7
Diabetes diagnosed by doctor 2.6 4.2 6.5 2.6 2.2 2.1 2.5 1.4 -2.3 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 -0.2 -0.6 -0.7 -0.5 -0.8 0.4 -0.8
Friendships satisfaction 0.6 0.7 2.4 -1.5 -0.6 -1.0 -0.7 0.4 0.8 -0.2
Qualifications: nursing, teaching 4.0 6.3 9.2 -2.4 -3.0 -3.0 -2.5 -1.1 2.7 -2.4
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 -0.3 -0.3 -0.4 0.1 0.2 0.4
Eye problems/disorders: Cataract 2.7 3.1 3.8 1.7 1.7 1.9 1.8 1.6 -1.9 1.8
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.1 -1.0 -1.1 -1.3 -0.8 -1.7 1.3 -0.7
Medication for cholesterol 0.8 1.2 3.0 -1.7 -1.1 -1.2 -1.0 0.0 1.3 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 2.8 1.0 1.5 1.5 1.7 1.4 -1.3 0.7
Back pain experienced in last month 3.4 5.0 8.1 1.7 2.8 2.2 2.4 2.1 -2.0 2.3
Mineral and other dietary supplements 0.4 0.6 1.2 0.9 0.9 0.6 0.6 0.5 -1.1 0.5
Breast cancer (self-reported) 0.4 0.5 2.5 -0.3 -0.4 -0.3 -0.2 -0.7 0.5 -1.6
Asthma (self-reported) 0.6 1.1 2.7 1.6 1.1 1.0 1.1 -0.1 -1.3 0.4
Osteoporosis (self-reported) 0.3 0.4 1.9 1.4 0.1 0.1 0.6 0.2 -0.5 -0.1
Osteoarthritis (self-reported) 0.9 1.1 5.9 -0.3 -0.6 -0.9 -0.6 -0.5 -0.2 -2.4
Medication: Aspirin 1.5 1.9 3.0 1.1 1.7 1.4 1.5 0.5 -1.4 1.7
Medication: Gliclazide 0.2 0.2 0.4 0.7 -0.6 -0.5 0.0 -0.4 0.2 -0.4
Illnesses of father: None of the above (group 1) 0.7 0.8 4.1 0.7 0.3 0.1 0.5 0.7 -0.6 2.0
Smoking status: Current 1.9 3.1 6.1 0.9 2.2 2.5 2.0 1.3 -1.6 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.6 0.5 -0.2 -0.2 0.2 0.8 -0.5 0.4
Whole body water mass 0.4 2.3 8.2 -1.7 -0.7 -1.1 -1.3 -2.9 1.2 -0.7
Leg predicted mass (right) 0.5 2.5 8.4 -2.1 -0.4 -1.2 -1.3 -2.9 1.1 -0.7
Arm fat mass (left) 0.3 1.4 4.3 -0.3 2.1 1.5 1.0 -0.8 -1.1 0.8
Number of self-reported non-cancer illnesses 0.2 0.3 0.8 0.9 0.8 0.4 0.4 0.4 -0.8 0.1
Average weekly champagne plus white wine intake 0.2 0.3 0.5 -0.6 -0.5 -0.7 -0.6 -0.4 0.3 -0.7
Miserableness 1.8 3.1 7.8 0.7 2.0 1.6 1.3 2.8 -1.9 1.2
Guilty feelings 3.1 4.6 6.3 1.4 2.4 2.2 1.8 2.5 -2.5 2.1
Wears glasses or contact lenses 0.3 0.4 1.0 -1.0 -0.3 -0.9 -0.7 0.1 0.4 -0.0
Ever taken oral contraceptive pill 0.3 0.3 0.5 0.7 0.2 -0.2 -0.2 -0.6 -0.7 -0.7
Hearing aid user 5.8 6.5 10.4 -2.7 -2.6 -2.1 -2.4 -3.0 3.2 -1.7
Mother’s age at death 0.5 0.6 2.8 -0.4 -1.0 -0.4 -0.3 0.1 0.2 -1.7
Financial situation satisfaction 0.3 0.3 1.2 1.1 0.0 -0.1 0.4 0.7 -0.7 -0.1
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.3 1.8 0.9 1.3 1.3 0.9 -1.8 0.3
Commuting to job workplace: Public transport 0.3 0.3 1.2 -0.6 -0.4 0.2 -0.1 0.1 1.1 0.6
Eye problems/disorders: Glaucoma 0.9 1.0 4.6 -0.1 1.1 0.9 0.1 -0.1 -0.7 2.1
Medication: Blood pressure 0.2 0.4 1.0 0.5 0.7 1.0 0.8 -0.4 -0.2 -0.6
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.0 0.4 1.4 1.2 1.0 1.0 -1.0 0.9
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.9 -1.7 -1.4 -1.4 -1.5 -0.9 1.5 -0.4
High cholesterol (Self-reported) 0.1 0.2 0.5 -0.3 0.5 -0.0 0.0 0.7 -0.6 0.5
Medication: Bendroflumethiazide 0.1 0.1 0.5 0.3 -0.1 -0.3 -0.3 -0.7 0.3 0.2
Medication: Paracetamol 0.8 1.3 2.0 -0.5 -1.0 -1.4 -1.3 -1.4 0.5 -1.4
Medication: Lisinopril 0.1 0.1 0.4 -0.1 -0.3 -0.6 -0.3 0.3 -0.1 -0.1
Medication: Atorvastatin 0.2 0.3 0.6 0.2 0.5 0.4 0.5 0.8 -0.4 -0.6
Illnesses of father: High blood pressure 0.7 0.9 1.5 1.2 1.0 1.2 1.1 0.1 -1.1 0.1
Alcohol drinker status: Never 1.4 1.7 5.5 -2.3 -1.3 -0.9 -0.8 -0.5 1.7 -0.6
Ever smoked 1.3 2.2 4.4 0.2 2.1 1.9 0.9 2.0 -0.7 1.5
Basal metabolic rate 0.2 1.3 5.9 -1.3 -0.1 -0.5 -0.7 -2.4 0.6 -0.3
Leg fat percentage (left) 1.3 4.6 8.9 1.1 3.0 2.8 2.4 0.7 -2.2 1.6
Arm fat-free mass (left) 0.2 1.1 5.1 -1.2 -0.2 -0.5 -0.7 -2.3 0.8 -0.1
Number of operations (self-reported) 0.2 0.3 1.0 -0.5 1.0 0.8 0.5 0.1 -0.4 -0.3
Average weekly beer plus cider intake 1.9 2.7 5.1 0.8 2.3 2.1 1.9 1.4 -1.7 0.7
Irritability 1.8 3.0 5.7 -0.5 2.4 1.8 1.2 2.4 -1.9 1.1
Risk taking 1.7 2.4 6.4 0.4 1.6 1.4 1.1 1.5 -1.5 2.5
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.3 -0.4 -1.5 -1.8 -1.4 -1.3 0.9 -0.6
Fractured/broken bones in last 5 years 0.4 0.5 1.6 -1.3 -0.6 -0.9 -0.6 0.2 0.7 0.0
Age started oral contraceptive pill 2.6 3.2 4.6 -1.3 -2.1 -2.1 -1.9 -1.8 1.6 -1.7
Diastolic blood pressure, automated reading 0.4 1.3 3.2 -0.3 -0.9 -0.6 -0.4 -1.8 1.3 -1.7
Ever depressed for a whole week 0.2 0.2 0.8 0.2 0.6 0.2 0.3 -0.9 -0.2 0.0
Unable to work because of sickness or disability 4.0 5.2 7.5 1.9 2.7 2.5 2.5 1.8 -2.7 1.5
Commuting to job workplace: Cycle 2.5 3.0 5.1 -1.7 -2.3 -2.2 -2.0 -1.1 1.8 -0.3
Myopia 1.7 2.5 4.1 -1.2 -1.6 -1.9 -1.8 -1.1 1.2 -2.0
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.4 -1.2 -0.9 -0.7 -0.6 -0.4 0.6 -0.2
Cholesterol lowering medication 0.2 0.4 0.6 -0.6 -0.3 -0.6 -0.7 -0.8 0.4 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.3 -0.1 0.8 0.7 0.5 0.6 -1.1 -0.8
Pain experienced in last month 0.8 1.4 2.4 -1.4 -1.5 -1.1 -1.6 -0.6 1.1 -0.5
Supplements: Calcium 0.0 0.0 0.1 0.2 -0.2 0.0 0.1 0.2 0.1 -0.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.3 0.4 0.4 0.4 0.4 0.1 0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.3 0.5 1.0 0.8 1.0 0.7 -1.1 0.7
Deep venous thrombosis (DVT) (self-reported) 5.9 7.5 9.2 -2.8 -2.5 -3.0 -3.0 -2.3 2.8 -2.7
Heart disease (siblings) 3.2 3.9 5.7 1.4 2.4 2.2 2.2 1.8 -2.3 1.4
Alcohol drinker status: Previous 1.1 1.3 4.1 0.2 -1.1 -0.9 -0.9 -2.0 0.5 -1.3
Pack years of smoking 0.7 1.0 2.2 0.7 1.5 1.2 1.2 -0.4 -1.0 0.7
Impedance of whole body 1.3 6.8 10.0 3.0 2.0 2.5 2.9 3.2 -2.7 1.6
Leg fat mass (left) 0.7 2.9 6.7 0.5 2.6 2.2 1.9 -0.0 -1.7 1.5
Arm predicted mass (left) 0.2 1.3 5.6 -1.2 -0.3 -0.6 -0.8 -2.4 0.9 -0.2