Hub : Genes

PANK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1520	0.0460	1.7e-06	0.098	NA	0.039	NA	0.073	8.1e-08	NA	6.1e-04	NA	3.8e-06
2	GTEx	Colon Transverse	0.2770	0.0570	2.8e-09	0.297	NA	0.276	NA	0.291	1.3e-14	NA	1.5e-13	NA	2.8e-14
3	GTEx	Esophagus Mucosa	0.1150	0.0430	2.3e-03	0.011	NA	0.049	NA	0.001	6.1e-02	NA	3.1e-04	NA	2.6e-01
4	GTEx	Esophagus Muscularis	0.1420	0.0500	2.0e-03	0.021	NA	0.017	NA	0.017	1.9e-02	NA	3.2e-02	NA	3.0e-02
5	GTEx	Testis	0.2440	0.0970	1.5e-03	0.116	NA	0.044	NA	0.065	7.8e-06	NA	5.1e-03	NA	7.6e-04
6	TCGA	Colon Adenocarcinoma	0.1970	0.0550	4.9e-14	0.273	0.231	0.249	NA	0.273	4.7e-16	1.5e-13	1.4e-14	NA	4.7e-16
7	TCGA	Prostate Adenocarcinoma	0.0547	0.0268	6.5e-04	0.017	0.026	0.020	NA	0.013	5.5e-03	8.9e-04	3.0e-03	NA	1.3e-02
8	TCGA	Rectum Adenocarcinoma	0.1790	0.0740	2.7e-03	0.051	0.104	0.046	NA	0.066	2.5e-02	2.0e-03	3.1e-02	NA	1.2e-02
9	TCGA	Stomach Adenocarcinoma	0.0840	0.0350	3.9e-05	0.074	0.052	0.073	NA	0.077	5.1e-06	1.2e-04	6.0e-06	NA	3.3e-06
10	TCGA	Thyroid Carcinoma	0.0420	0.0230	4.9e-03	0.049	0.013	0.028	NA	0.034	1.5e-05	1.6e-02	9.7e-04	NA	2.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.7	1.8	-1.4	-0.4	0.9	-0.8	-1.2	-0.5	0.2	0.0	-1.2	-0.3
Bipolar Disorder or Schizophrenia	1.5	3.7	13.5	-3.5	0.9	-0.9	-2.1	-3.7	0.4	0.5	0.6	-1.9	-0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.5	0.1	0.6	-0.2	-0.4	-0.0	0.2	0.8	0.4	-0.5
Depression (Nagel 2018)	0.6	0.9	1.9	-0.7	0.6	0.6	-1.4	-0.6	0.7	1.4	1.0	0.0	1.3
Intelligence (Savage-Jansen 2018)	0.5	1.5	4.1	-1.8	-0.2	-0.6	-1.8	-1.0	-0.5	-0.4	-1.1	-1.2	-2.0
Neuroticism (Nagel 2018)	0.5	1.1	3.7	1.1	0.9	0.0	0.1	0.3	0.9	1.0	1.8	1.9	0.6
Schizophrenia (2018)	2.0	4.2	13.8	-3.4	1.4	-2.2	-2.1	-3.7	0.9	0.5	0.8	-1.4	-1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	0.1	0.5	-1.3	-0.1	0.1	0.5	-0.8	0.6	0.9	-0.1
Worry (Nagel 2018)	0.9	2.0	5.5	0.2	1.7	-0.5	-0.5	0.1	1.8	0.9	2.4	2.2	1.2
Alzheimer’s Disease (in mother)	0.3	0.4	3.3	0.3	0.1	-0.2	1.8	-0.2	0.1	-0.0	0.2	-0.4	0.6
Alzheimer’s Disease (in father)	1.3	1.4	3.7	-1.3	1.4	-1.8	-1.9	-0.2	1.3	0.7	0.7	1.1	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.4	0.8	-0.9	0.5	-0.1	0.7	0.1	0.2	0.1	0.3
Crohns Disease (2017)	0.3	0.6	2.1	-0.3	-1.0	1.4	-0.3	0.4	-0.9	0.0	-1.0	-0.9	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.7	-0.3	0.4	-0.3	-0.7	-0.3	0.0	-0.7	-0.8	-0.5
Ulcerative Colitis (UC)	0.2	0.4	1.7	-0.7	0.1	-0.4	-0.4	-1.3	-0.0	-0.4	-0.5	-0.8	-0.6
Major Depression (MDD)	1.0	1.2	4.7	-0.8	-0.5	1.3	1.3	-1.4	-0.6	0.3	-0.9	-2.2	0.4
Reaction Time	0.5	1.0	3.8	1.3	-0.5	-0.5	-0.4	0.8	-0.6	-0.8	-0.9	1.1	-1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.8	-0.9	-0.1	0.6	-1.3	0.1	-0.3	-0.5	-0.4	-0.4	-1.7
Breast Cancer	2.1	5.1	11.2	-2.8	3.3	-0.0	0.4	-2.8	3.2	1.8	2.4	1.2	1.8
Ovarian Cancer	2.4	3.2	12.7	-0.6	1.4	0.8	1.8	-0.7	1.7	1.6	2.6	0.3	3.6
Prostate Cancer	0.5	0.8	2.4	-0.0	-0.4	1.6	-1.3	0.3	-0.5	-0.5	-1.4	-0.5	-0.7
Age at First Birth	1.0	1.4	3.4	0.9	-1.1	-0.2	-1.2	1.4	-1.0	-1.8	-1.8	-0.1	-1.0
Bipolar Disorder (2011)	2.8	2.7	8.6	-1.0	1.6	2.1	-0.4	-1.0	1.8	1.7	1.7	0.5	2.9
Body Mass Index (BMI) (2010)	0.4	0.5	2.6	0.1	-0.5	1.6	-0.6	0.3	-0.3	0.8	-0.4	-0.5	0.9
Coronary Artery Disease (CAD)	0.9	1.1	3.2	1.6	0.0	-0.4	0.7	1.8	0.1	-0.9	-0.8	1.6	-0.5
Crohns Disease (2012)	0.2	0.3	0.7	-0.6	-0.4	0.9	-0.1	-0.1	-0.4	0.7	-0.4	-0.8	-0.3
Mean Putamen Volume	0.5	0.6	1.5	-1.1	0.2	-1.2	-1.0	-1.1	0.1	0.8	0.1	-0.8	0.3
Fasting Glucose	0.6	0.8	4.3	-1.1	-0.4	0.5	-2.1	-0.4	-0.5	-0.3	-0.3	-0.9	0.1
HbA1C	0.6	0.7	2.5	-1.6	0.8	-0.6	0.2	-0.8	1.0	-0.2	0.2	-0.3	1.2
HDL Cholesterol	0.3	0.5	2.2	0.3	0.0	-1.5	1.4	0.8	0.1	-0.5	-0.6	0.1	-0.1
LDL Cholesterol	1.2	1.9	6.6	-0.3	-1.2	-0.6	0.4	-0.8	-1.5	-1.3	-2.6	-1.7	-1.8
Lupus	1.3	2.0	5.0	-0.4	-1.5	0.2	-2.1	0.4	-1.7	-1.5	-1.5	-0.9	-2.2
Neuroticism (2016)	0.4	0.5	1.8	0.2	0.3	1.4	-0.0	0.3	0.3	1.2	1.0	-0.2	0.8
Primary Biliary Cirrhosis	0.4	0.5	2.8	0.3	-0.5	-0.3	-1.7	0.1	-0.6	-0.9	-0.6	0.3	-0.8
Rheumatoid Arthritis	0.6	0.8	3.4	0.6	0.1	0.7	1.9	0.5	0.4	0.8	1.1	0.2	1.3
Schizophrenia (2014)	1.2	2.6	9.1	-3.0	1.2	-1.2	-1.4	-3.0	0.8	0.5	0.9	-1.1	-0.7
Triglycerides	0.2	0.3	1.0	-0.6	0.3	0.4	-0.5	-1.0	-0.0	0.3	-0.4	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.8	1.2	1.4	1.0	0.7	0.8	1.6	1.0	0.8	2.2	1.5
Ulcerative Colitis	0.2	0.3	0.5	0.0	0.7	-0.6	-0.7	-0.7	0.6	0.3	-0.1	0.6	0.4
Blood Eosinophil Count	0.2	1.2	4.7	1.5	-0.0	2.2	-0.1	2.0	0.0	-0.4	0.1	0.9	-0.5
Blood Platelet Count	0.4	4.6	10.0	2.3	1.2	3.0	1.0	2.2	1.7	0.9	1.9	3.2	2.7
Blood Red Count	2.3	22.1	47.2	5.0	-4.6	-1.6	-1.4	5.7	-4.8	-6.2	-5.2	0.8	-6.9
Blood White Count	0.9	6.3	21.9	4.7	-2.5	1.8	0.1	4.6	-2.1	-1.3	-1.6	1.3	-0.4
Heel T-Score	0.2	1.4	5.2	0.6	1.2	-1.6	0.2	0.7	1.4	-0.1	0.8	2.3	1.0
BMI	0.7	4.2	10.5	0.6	1.7	1.4	-0.7	0.4	2.0	2.9	2.6	2.5	3.2
Height	0.5	9.1	19.1	-0.3	4.2	-1.9	2.2	-0.4	4.4	2.8	3.4	4.1	3.2
Waist Hip Ratio (WHR)	0.1	0.5	1.4	-0.1	0.4	-1.1	-0.8	0.1	0.3	-0.6	0.4	0.6	-1.2
Systolic Blood Pressure	1.0	5.0	13.6	0.0	2.5	0.4	-1.3	0.2	2.9	2.5	2.8	2.4	3.7
Smoking Status	0.6	1.3	3.8	0.2	1.5	0.2	0.6	0.5	1.5	1.1	1.6	2.0	0.6
Allergy or Eczema	0.3	0.7	2.0	0.8	-0.8	-0.6	0.0	1.2	-0.9	-0.2	-1.0	-0.2	-1.4
Cardiovascular Disease	0.4	1.4	4.2	1.5	0.6	0.8	-0.6	1.1	0.8	0.8	1.1	2.1	1.4
Hypothyroidism (self reported)	0.5	1.1	4.2	2.1	-0.8	1.5	0.4	1.5	-0.5	0.1	-0.2	0.9	0.6
Respiratory disease	0.1	0.2	0.3	-0.2	0.5	0.5	-0.4	-0.3	0.5	-0.0	0.4	0.4	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.1	0.5	-0.3	-0.6	-1.4	0.7	-0.2	0.3	0.8	0.5	0.2
Lung FEV1/FVC ratio	0.8	4.2	9.8	1.0	-3.1	0.6	0.1	1.3	-3.1	-0.2	-2.9	-2.0	-2.5
Lung FVC	0.4	2.1	6.5	-2.5	0.3	0.8	-0.8	-2.3	0.2	1.1	0.5	-2.3	1.0
Neuroticism	1.0	2.5	7.0	0.8	1.9	0.7	0.6	-0.1	1.9	1.4	2.5	2.6	1.2
Chronotype (morning person)	1.2	2.8	5.7	-2.2	2.0	-0.1	-1.5	-2.0	1.9	2.4	1.3	0.6	1.3
Hair Pigment	0.0	1.1	3.2	-0.3	1.4	-0.7	0.2	-0.0	1.4	0.9	1.6	1.8	-0.1
Tanning	0.1	1.3	3.8	1.4	0.1	-1.3	-0.9	1.3	0.1	-1.4	0.2	1.9	-1.0
Hand grip strength (left)	0.5	1.4	4.1	0.6	1.2	-0.2	0.9	0.5	1.3	2.0	0.8	2.0	0.9
Number of treatments/medications taken	0.2	0.4	1.0	-0.8	0.8	0.6	-0.0	-1.0	0.7	-0.2	0.5	-0.2	0.6
Average weekly spirits intake	0.5	0.7	2.0	0.3	-1.1	0.8	-0.6	-0.0	-1.0	-1.4	-0.6	-0.9	-0.1
Sensitivity / hurt feelings	1.3	2.2	7.1	0.5	0.9	1.1	1.4	0.7	1.3	1.8	2.2	0.8	2.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.9	-0.7	0.4	0.7	-0.5	-0.5	0.4	1.4	0.6	-0.4	1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.9	-0.7	0.6	-0.3	0.3	-0.6	0.3	-0.8	-0.1	0.4
Relative age of first facial hair	0.9	2.0	8.5	1.8	0.6	0.0	2.9	1.2	0.8	0.4	0.5	2.0	1.0
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	5.2	0.5	-1.1	0.5	1.2	-0.4	-1.2	-1.7	-2.3	-1.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.0	0.6	0.6	1.5	-0.4	-0.1	0.8	0.6	1.2	1.3	1.7
Ever had hysterectomy (womb removed)	2.5	2.8	4.8	-2.1	1.5	2.1	-1.4	-2.2	1.6	0.8	1.9	-0.0	1.9
Systolic blood pressure, automated reading	1.3	3.8	7.3	-0.1	2.5	-0.5	-1.3	-0.1	2.7	1.7	2.5	2.7	2.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	4.2	-0.2	-1.0	-0.4	1.0	-0.8	-0.9	0.7	-0.1	-2.1	0.4
Angina	0.3	0.4	1.7	0.3	-0.5	0.0	-0.8	0.6	-0.6	-0.9	-0.5	0.3	-1.3
Medication for hormone replacement therapy	1.1	1.3	5.6	-1.8	-0.1	-0.1	-0.4	-2.4	-0.3	-0.0	-0.0	-1.9	-0.3
Vitamin and mineral supplements	2.5	3.3	9.6	0.7	1.9	0.1	-0.2	-0.4	2.0	2.4	3.1	2.3	2.2
Supplements: Zinc	0.5	0.5	1.8	0.1	-0.3	-0.3	-0.1	-0.5	-0.5	-1.3	-1.2	-0.4	-0.9
Medication: Co-codamol	1.0	1.1	3.1	0.3	1.1	-0.1	0.2	0.2	1.2	1.1	1.6	1.8	1.1
Medication: Metformin	0.3	0.4	2.8	0.2	0.2	-0.3	0.2	0.3	0.4	0.6	0.5	0.0	1.7
Diabetes (father)	1.5	1.8	11.8	-0.4	1.1	-3.4	1.1	-0.4	1.0	0.2	1.4	0.9	0.2
Diabetes (mother)	1.0	1.3	4.0	-0.0	1.1	0.5	0.3	0.4	1.4	0.7	1.8	1.1	2.0
Severe depression (siblings)	0.8	0.9	3.4	1.2	0.8	0.3	-0.7	0.9	0.9	0.6	0.9	1.8	0.4
Pack years adult smoking proportion	1.2	1.9	6.8	-0.7	1.4	0.3	-0.1	-1.4	1.4	1.3	2.6	0.5	1.8
Impedance of leg (right)	0.6	3.0	6.7	2.1	-1.7	0.4	0.2	2.6	-1.7	-2.5	-1.3	0.5	-2.0
Leg fat-free mass (left)	0.9	4.5	11.9	-0.2	2.2	0.5	0.7	-0.9	2.5	3.3	2.4	1.9	3.4
Trunk fat percentage	0.7	2.9	10.3	1.6	0.7	0.4	0.2	1.0	1.2	1.5	2.5	2.1	3.2
Hand grip strength (right)	0.7	1.8	5.8	0.1	1.2	0.4	0.2	-0.0	1.4	2.4	1.5	1.4	2.0
Townsend deprivation index at recruitment	0.3	0.4	1.6	0.3	-0.1	0.7	1.3	-0.4	-0.2	-0.5	-0.8	0.0	-0.8
Current tobacco smoking	0.9	1.4	4.7	-1.1	1.5	0.7	-0.3	-0.8	1.5	2.2	1.2	0.6	1.0
Average weekly fortified wine intake	0.1	0.2	0.9	0.3	-0.3	0.4	0.1	0.4	-0.3	-0.9	-0.3	-0.2	-0.3
Maternal smoking around birth	1.0	1.5	3.8	1.3	-0.1	1.6	-1.5	1.9	0.2	-0.0	0.5	1.4	1.3
Fed-up feelings	0.4	0.6	1.9	-1.3	0.2	0.1	-1.4	-1.1	-0.0	0.1	0.2	-0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.4	0.5	-0.5	1.2	0.2	0.4	-0.4	0.8	-0.0	0.0	0.5
Relative age voice broke	3.3	5.0	15.8	2.6	1.7	-1.3	3.2	1.7	2.0	0.4	1.5	4.0	1.8
Taking other prescription medications	0.9	1.4	2.7	-0.7	1.4	0.1	0.9	-1.4	1.4	1.4	1.3	0.5	1.6
Age when periods started (menarche)	0.3	0.6	1.4	-0.6	1.1	1.0	-0.6	0.2	1.0	-0.2	0.6	1.2	-0.4
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	6.1	-2.4	1.0	0.4	-1.7	-2.5	0.9	1.4	1.5	-1.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.2	1.3	0.1	0.9	-0.2	1.7	0.4	0.3	0.8	1.8	1.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	7.5	-1.6	0.0	-2.7	-0.9	-1.4	-0.2	0.5	-0.7	-1.4	-0.7
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.5	-0.3	-0.0	-0.5	-0.0	-0.3	0.9	-0.2	-0.6	0.1
Serious illness, injury or assault to yourself	2.5	3.0	6.4	-1.7	1.4	2.3	0.3	-2.5	1.5	1.4	1.4	-1.0	2.5
High blood pressure	0.7	2.1	4.4	-0.0	1.7	0.2	-1.9	-0.0	1.8	1.1	1.5	2.1	1.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	0.4	-1.2	0.3	-0.4	0.7	-1.2	-0.5	-1.0	-1.2	-1.1
Multivitamins +/- minerals	1.8	2.2	7.6	-0.2	-1.4	0.5	0.6	0.4	-1.5	-2.2	-2.8	-1.4	-1.7
Stomach or abdominal pain in last month	0.8	1.0	3.0	-0.1	1.4	0.5	-0.0	-0.4	1.3	0.6	1.5	1.7	0.4
Supplements: Glucosamine	1.0	1.2	3.8	0.1	-1.4	-0.1	-0.2	0.7	-1.4	-1.4	-1.9	-1.0	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.6	-0.5	0.2	-0.3	0.5	-0.3	0.0	-1.2	-0.1	0.1	-0.9
Medication: Atenolol	0.6	0.8	3.0	1.7	-0.2	0.5	-0.1	1.1	-0.1	-1.2	-0.2	1.3	-0.1
Medication: Levothyroxine sodium	0.2	0.3	1.7	1.3	-0.3	-0.7	0.5	0.3	-0.2	-0.3	-0.1	0.2	0.5
Sitting height	0.2	1.3	3.5	-0.6	1.8	-0.9	0.7	-0.2	1.7	1.0	0.8	1.9	0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	2.1	-0.5	-0.1	1.4	0.3	-0.1	-0.1	-0.4	-0.8	-0.5	-0.1
High blood pressure (mother)	0.6	0.8	3.8	-0.6	0.5	0.8	-0.4	-0.6	0.7	0.9	1.1	-0.1	2.0
Body mass index (BMI)	0.9	3.8	14.2	0.8	1.3	0.6	0.3	-0.0	1.7	2.8	2.7	1.9	3.8
Impedance of leg (left)	0.6	2.8	6.8	2.1	-1.8	0.3	0.4	2.6	-1.7	-2.4	-1.2	0.5	-1.8
Leg predicted mass (left)	0.9	4.5	11.6	-0.2	2.3	0.5	0.7	-0.9	2.6	3.3	2.4	2.0	3.4
Trunk fat mass	1.0	4.5	14.1	1.5	1.4	0.3	0.5	0.9	1.9	2.4	2.9	2.8	3.8
Waist circumference	1.0	3.7	9.9	0.5	1.7	-0.2	-0.1	-0.1	2.0	2.5	3.0	2.3	3.1
Number of incorrect matches in round	0.9	1.4	4.2	1.0	0.7	-2.1	1.2	1.2	0.6	-1.1	-0.4	1.9	-0.8
Past tobacco smoking	1.4	2.5	8.3	-2.7	0.5	-0.1	-0.0	-2.9	0.4	1.2	0.1	-2.6	1.0
Alcohol usually taken with meals	0.9	1.5	4.8	0.6	-1.2	-2.2	-0.4	0.7	-1.2	-2.1	-0.5	-0.9	-1.1
Nervous feelings	0.3	0.5	1.1	-0.3	1.1	-0.4	-0.3	0.0	1.0	0.7	0.9	1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.9	0.6	-0.8	0.5	-1.7	1.3	-0.7	0.5	-0.2	0.1	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	1.5	0.7	-0.6	-0.1	1.2	-0.1	-0.7	-1.2	-1.0	-0.2	-1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	-0.2	0.5	-1.3	0.9	-0.1	0.5	-0.3	0.5	0.4	0.1
Had menopause	0.3	0.3	0.9	0.8	0.2	-0.7	-0.7	0.5	0.3	-0.7	-0.3	0.9	0.1
Had other major operations	0.6	0.7	3.4	-0.4	-0.5	-0.4	0.9	-1.0	-0.7	-0.3	-0.9	-1.8	-0.5
Forced vital capacity (FVC)	0.2	0.7	3.1	-0.9	0.6	-0.0	1.8	-1.1	0.5	0.2	-0.1	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.5	1.8	-0.7	-0.1	-0.3	1.9	-0.5	-0.6	-0.2	1.5	-0.2
Ever unenthusiastic/disinterested for a whole week	2.2	2.6	6.8	-1.9	-0.6	-1.0	-0.6	-2.4	-1.0	-0.7	-1.9	-2.6	-1.8
Qualifications: None of the above	0.9	1.9	5.2	1.7	0.7	1.2	1.3	0.3	1.0	1.0	1.7	1.6	2.3
Financial difficulties in last 2 years	0.0	0.1	0.1	0.1	0.3	-0.1	0.3	0.1	0.2	0.4	0.3	-0.1	0.2
Mouth/teeth dental problems	2.2	3.5	13.0	-3.6	1.7	0.5	-1.6	-2.5	1.5	1.8	1.5	-1.2	0.4
Heart attack	0.5	0.6	2.0	0.9	0.0	-0.3	-0.7	1.1	0.3	0.9	-0.1	0.9	1.4
Allergy	0.1	0.2	1.1	0.7	-0.3	-1.0	0.7	0.1	-0.2	-0.2	-0.1	0.5	0.1
Pain all over the body in last month	0.8	0.9	1.9	-0.8	1.4	-0.6	0.8	-0.8	1.3	0.6	0.9	1.0	0.7
Diabetes (self-reported)	0.4	0.6	1.9	-1.0	0.3	-0.3	-0.9	-0.4	0.5	0.8	1.0	-0.5	1.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.8	1.0	-1.3	-0.6	-0.4	1.5	-1.3	-1.7	-1.3	-0.5	-1.6
Medication: Ramipril	1.5	1.9	8.9	1.7	0.6	-0.1	-0.3	2.3	0.8	-1.0	0.5	3.0	0.2
Medication: Simvastatin	1.1	1.6	3.5	-0.9	1.7	0.3	-0.5	-1.0	1.7	1.1	1.9	1.0	1.4
Fluid intelligence score	0.5	1.1	7.5	-1.0	0.7	-0.0	-2.7	0.1	0.6	0.2	0.2	0.8	-0.8
Illnesses of siblings	1.6	2.2	12.6	-1.2	1.1	-3.5	1.8	-1.0	0.8	0.1	-1.0	0.1	-1.1
Neuroticism score	0.9	2.0	5.3	0.2	1.5	1.1	0.0	0.1	1.6	1.5	2.3	2.0	1.5
Weight	1.3	6.3	17.9	0.8	2.3	0.3	1.0	-0.0	2.7	3.4	3.2	2.9	4.2
Impedance of arm (right)	0.5	2.1	6.0	-0.6	-1.3	-0.5	-0.8	-0.4	-1.6	-2.4	-1.1	-1.9	-2.2
Arm fat percentage (right)	0.6	2.4	10.0	0.5	1.0	0.2	-0.3	-0.3	1.3	1.9	2.5	1.3	3.2
Trunk fat-free mass	1.2	6.6	13.4	-0.3	3.1	0.2	1.4	-0.8	3.4	3.7	2.9	2.9	3.5
Hip circumference	0.8	3.5	9.8	1.1	1.4	-0.3	0.6	0.2	1.7	2.6	2.6	2.3	3.1
Time employed in main current job	0.4	0.5	1.1	0.1	-0.6	-0.4	0.8	-0.3	-0.8	-0.2	-1.1	-0.9	-0.9
Alcohol intake versus 10 years previously	0.8	1.2	4.0	-1.2	1.0	0.6	0.3	-2.0	1.0	0.8	1.1	-0.6	1.4
Father’s age at death	0.3	0.4	2.3	-0.4	0.0	-0.1	1.5	-0.6	0.1	0.2	-0.3	-0.5	0.7
Worrier / anxious feelings	1.2	2.3	5.2	0.1	2.0	-0.7	0.8	-0.1	2.1	0.2	2.3	2.2	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.6	-0.4	-0.4	1.6	0.3	-1.1	-0.4	0.4	-0.0	-1.4	0.1
Falls in the last year	0.2	0.3	1.6	0.5	0.4	0.5	1.3	-0.3	0.4	-0.1	0.1	0.5	0.7
Hair/balding pattern: Pattern 3	0.7	1.0	3.3	-1.0	-0.9	1.0	-1.8	-0.3	-1.0	0.5	-0.4	-1.7	-0.4
Number of live births	0.2	0.3	1.4	-0.5	0.3	-0.2	-0.7	-0.5	0.2	0.6	1.2	0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.7	-0.5	-0.5	0.1	1.3	-0.4	-0.6	-0.1	-1.0	-1.3	-0.4
Pulse rate	0.3	0.6	1.6	0.3	-0.5	1.2	1.3	0.5	-0.4	0.7	-0.2	-1.0	0.9
Happiness	1.4	1.7	5.4	-2.2	1.1	-0.9	-1.4	-2.3	0.8	0.6	0.6	-0.9	-0.2
Noisy workplace	1.1	1.4	3.3	0.7	-1.5	0.7	1.8	0.2	-1.5	-0.6	-1.4	-1.6	-0.2
Qualifications: A levels/AS levels or equivalent	2.4	5.3	11.9	-1.0	-2.5	-1.0	-1.3	-0.3	-2.8	-2.5	-3.0	-2.8	-3.4
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	5.6	1.6	-2.4	1.4	-2.2	1.4	-2.1	-0.7	-1.8	-1.2	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.3	3.6	1.8	0.3	-0.3	1.3	1.3	0.5	-0.6	1.0	1.9	0.8
Asthma	0.6	1.3	2.3	-1.0	1.5	0.9	0.8	-1.2	1.5	0.7	1.4	0.4	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	5.8	0.1	-0.6	-0.9	0.5	0.0	-0.9	-2.0	-1.0	-0.2	-2.4
Medication: Cholesterol lowering	0.5	0.7	1.6	-0.8	1.2	-0.4	-0.8	0.2	1.3	0.9	0.6	1.1	0.6
Depression (self-reported)	0.4	0.5	2.5	-0.6	0.2	-1.6	0.9	-0.7	0.0	-0.5	0.2	-0.6	-0.5
Medication: Lansoprazole	1.2	1.4	3.4	-0.8	1.3	-0.0	1.3	-1.8	1.3	0.7	1.6	0.0	1.5
Prospective memory result	0.3	0.4	1.8	0.6	0.4	-0.8	0.6	0.4	0.4	0.2	0.2	1.3	-0.3
Lung cancer (father)	4.1	4.8	7.5	2.7	-2.7	-0.2	1.6	2.7	-2.7	-1.8	-2.3	-0.4	-2.6
Illnesses of mother	0.6	0.7	2.8	0.3	0.4	-1.6	0.1	-0.0	0.1	-0.8	-0.4	1.0	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.8	-0.5	-0.6	0.4	0.9	-0.5	-0.7	-0.7	-1.3	-1.3	-0.6
Pulse wave Arterial Stiffness index	2.3	2.7	5.9	1.3	-2.4	0.7	-1.0	1.0	-2.3	-2.3	-1.7	-1.6	-0.9
Impedance of arm (left)	0.5	2.2	7.8	0.1	-1.5	-0.6	-0.3	0.1	-1.7	-2.8	-1.2	-1.6	-2.1
Arm fat mass (right)	1.1	4.4	15.7	0.8	1.6	0.3	0.3	-0.1	2.1	2.6	3.0	2.2	4.0
Trunk predicted mass	1.1	6.5	13.2	-0.2	3.0	0.2	1.4	-0.7	3.3	3.6	2.9	2.9	3.5
Standing height	0.4	4.2	8.8	-0.1	2.9	-0.3	1.8	-0.4	3.0	2.2	2.1	2.9	1.9
Length of working week for main job	0.6	0.6	2.3	1.5	0.1	0.9	-0.3	1.1	0.1	0.1	0.1	1.5	-0.2
Exposure to tobacco smoke at home	2.1	2.4	6.3	-0.1	1.8	-1.0	1.1	-0.8	1.8	1.8	2.5	1.8	1.3
Breastfed as a baby	0.8	1.0	2.3	-1.0	1.4	-0.8	0.8	-1.0	1.3	-0.3	1.5	0.5	0.3
Tense / ‘highly strung’	0.7	1.2	3.8	-0.0	0.3	1.9	-1.9	0.3	0.5	1.1	1.1	0.8	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.3	-1.9	1.0	-0.0	-0.4	-2.1	0.7	0.6	-0.1	-0.8	-0.4
Hair/balding pattern: Pattern 4	0.1	0.4	1.1	1.1	-0.3	-0.2	-0.1	0.8	-0.2	-0.7	-0.7	0.7	-0.4
Birth weight of first child	0.2	0.4	2.1	0.4	-0.2	0.5	0.7	0.2	-0.4	-0.3	-0.6	0.5	-1.4
Peak expiratory flow (PEF)	0.5	1.1	3.8	0.7	-1.4	0.8	1.9	0.4	-1.3	-0.1	-0.9	-1.1	-0.4
Pulse wave reflection index	0.4	0.5	1.1	0.5	-1.0	0.4	-0.7	0.4	-1.0	-1.1	-0.9	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	7.2	0.2	1.1	0.5	0.9	-0.5	1.3	1.7	1.4	1.1	2.7
Loud music exposure frequency	1.5	1.6	3.5	-0.7	1.5	-0.0	-1.5	0.2	1.6	0.5	1.8	1.9	1.1
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	12.3	0.5	-2.5	-0.9	-0.3	1.1	-2.7	-2.0	-3.0	-1.5	-3.5
Mouth/teeth dental problems: Bleeding gums	2.9	3.8	6.6	2.5	-2.3	-1.5	0.9	1.9	-2.3	-2.1	-2.6	-0.4	-1.8
Blood clot in the leg (DVT)	2.8	3.6	8.1	-1.6	2.8	-0.2	-0.3	-1.1	2.8	1.5	2.8	1.7	1.8
Medication: Paracetamol	0.9	1.6	4.4	2.0	-1.3	1.4	2.1	1.1	-1.1	-0.6	-0.8	-0.6	0.2
Headache pain in last month	0.6	1.0	2.4	1.5	-1.2	1.6	1.0	0.8	-1.1	-0.9	-0.1	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.9	0.5	-1.3	0.1	1.3	-0.4	-1.4	-1.4	-1.1	-1.4	-1.1
Glaucoma (self-reported)	1.7	2.0	4.6	-0.6	1.9	-0.0	0.5	-0.9	1.9	1.3	2.1	1.5	1.6
Gout (self-reported)	2.0	2.7	5.0	1.2	-2.2	1.2	-1.3	1.8	-2.2	-1.0	-2.2	-0.6	-1.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.9	1.4	-0.6	0.7	0.4	0.9	-0.4	0.5	-0.3	0.4	0.4
Medication: Amlodipine	0.8	1.2	2.5	-1.0	1.5	-0.0	0.4	-1.1	1.5	1.2	0.9	0.2	1.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.6	-1.4	1.3	0.3	0.4	-1.6	1.2	1.2	1.4	-0.2	1.3
Birth weight	0.5	1.1	3.0	-1.1	1.7	-1.3	0.2	-0.7	1.5	1.2	0.3	0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	1.0	0.4	1.4	0.2	0.8	0.7	0.7	0.8	1.1	1.2
High blood pressure (siblings)	1.3	1.9	10.7	-0.1	-0.1	3.3	-0.7	-1.0	-0.0	1.0	1.8	-0.5	1.5
Forced vital capacity (FVC), Best measure	0.2	0.8	2.1	-1.2	0.3	0.6	1.3	-1.4	0.2	-0.2	-0.3	-1.2	0.3
Body fat percentage	0.7	2.9	11.0	1.6	0.6	0.4	-0.1	1.0	1.1	1.6	2.4	2.1	3.3
Leg fat percentage (right)	0.8	2.8	7.4	2.2	0.0	0.5	-1.0	2.0	0.5	1.3	1.7	2.3	2.7
Arm fat-free mass (right)	1.2	6.1	13.9	0.9	2.5	0.5	1.8	0.2	2.9	3.2	2.6	3.3	3.7
Exposure to tobacco smoke outside home	0.5	0.7	1.7	-1.1	0.3	1.3	-0.8	-1.2	0.1	0.7	-0.6	-0.6	-0.8
Comparative body size at age 10	0.6	1.6	7.7	0.1	0.8	0.7	1.2	-0.4	1.1	1.8	0.9	0.5	2.8
Number of full brothers	0.7	0.9	1.9	1.0	-1.4	0.9	1.2	0.8	-1.3	-0.7	-0.6	-0.6	-0.3
Worry too long after embarrassment	0.8	1.4	3.5	1.7	0.3	-0.6	0.9	1.5	0.6	0.6	1.2	1.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.1	-0.3	-0.5	-0.1	1.2	-0.5	-0.7	-1.5	-0.6	-1.0	-0.9
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.7	0.7	0.1	-0.5	-0.6	0.6	-0.2	0.1	-0.2	0.3
Number of children fathered	1.0	1.1	3.7	0.2	1.3	-1.4	0.5	0.1	1.3	0.3	1.1	1.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.6	-0.9	-0.6	-1.6	0.3	-0.8	-0.9	-1.0	-1.0	-1.4	-1.6
Age at first live birth	1.6	2.9	4.8	1.1	-2.1	-0.9	0.2	1.7	-2.1	-2.0	-2.2	-0.9	-2.2
Pulse wave peak to peak time	2.1	2.4	5.3	-1.1	2.3	-0.6	1.0	-0.7	2.2	2.2	1.6	1.6	1.0
Health satisfaction	0.4	0.5	2.0	-0.8	0.2	-1.4	0.7	-0.7	0.2	0.5	0.5	-0.8	0.4
Shortness of breath walking on level ground	0.3	0.3	1.5	0.5	-0.1	0.2	-1.2	0.6	-0.1	-0.4	0.4	0.8	-0.2
Qualifications: College or University degree	0.6	1.9	4.7	-1.7	-0.6	-1.0	-0.5	-1.2	-0.9	-1.5	-1.3	-2.2	-1.8
Eye problems/disorders: None of the above	1.6	1.9	5.6	1.2	-1.5	-0.3	-0.8	1.0	-1.6	-1.4	-2.4	-0.2	-1.9
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.2	0.7	0.2	1.4	-1.8	0.7	0.4	0.2	0.8	1.5	1.0
Emphysema/chronic bronchitis	0.5	0.5	3.7	0.4	-0.1	1.9	0.1	0.2	-0.0	0.6	0.8	0.1	0.6
Medication for pain relief, constipation, heartburn	0.6	0.9	5.1	-1.1	-0.3	-1.0	-2.2	-0.4	-0.3	0.5	-0.5	-0.9	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.6	0.1	0.3	0.4	0.8	-0.4	0.3	0.0	0.5	0.3	-0.1
Medication: Blood pressure	0.5	0.8	1.9	0.2	0.9	-0.1	-0.8	0.8	1.0	1.2	0.8	1.4	1.0
Angina (self-reported)	0.5	0.6	2.8	0.3	-0.5	-0.3	-0.8	0.7	-0.7	-0.9	-0.7	0.4	-1.7
Migraine (self-reported)	0.6	0.7	2.7	-0.9	-0.5	0.9	-0.7	-1.1	-0.6	-0.6	0.2	-1.6	-0.6
Medication: Ibuprofen	0.6	0.7	2.9	0.3	-0.3	-0.3	0.6	0.4	-0.5	-1.4	-0.8	0.3	-1.7
Medication: Allopurinol	1.5	1.9	3.3	1.4	-1.8	0.7	-1.5	1.5	-1.8	-0.9	-1.8	-0.0	-1.5
Medication: Omeprazole	5.7	6.8	12.9	-2.6	3.4	-0.3	-0.1	-1.8	3.5	2.9	3.6	0.9	3.5
Medication: Seretide 50 evohaler	1.3	1.5	5.9	-0.3	-0.9	1.4	1.4	-0.9	-0.9	0.9	-1.1	-2.4	0.7
Mean time to correctly identify matches	0.4	0.9	2.3	1.4	-0.2	-1.0	-0.3	0.9	-0.4	-0.7	-0.3	1.3	-1.5
Heart disease (mother)	0.9	1.1	5.6	0.5	-1.0	2.4	-1.0	0.9	-0.9	0.9	-0.6	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.5	0.5	-1.3	-0.1	0.4	0.9	-1.3	-0.8	-1.6	-1.0	-0.8
Whole body fat mass	1.0	4.2	14.5	1.4	1.3	0.4	0.2	0.6	1.8	2.5	2.7	2.6	3.8
Leg fat mass (right)	1.0	4.0	14.7	1.4	1.1	0.6	-0.2	0.8	1.7	2.4	2.5	2.5	3.8
Arm predicted mass (right)	1.3	6.6	13.8	1.0	2.6	0.3	1.9	0.5	3.0	3.3	2.8	3.6	3.7
Pulse rate, automated reading	0.5	1.6	4.7	1.9	-1.0	2.2	1.6	1.4	-0.7	0.7	0.0	-0.1	1.0
Alcohol intake frequency.	0.3	0.7	2.2	0.8	0.6	1.1	0.9	-0.1	0.7	-0.1	1.0	0.6	1.5
Comparative height size at age 10	0.4	1.9	4.6	-0.5	2.1	-0.4	0.5	-1.1	2.1	1.5	1.6	1.6	0.9
Number of full sisters	0.7	0.8	3.0	-0.0	0.3	1.7	-1.1	-0.4	0.4	0.4	1.1	0.2	1.5
Suffer from ‘nerves’	0.1	0.2	0.5	0.4	0.1	-0.1	-0.4	0.4	0.2	0.4	0.7	0.3	0.6
Overall health rating	1.7	3.7	8.0	-1.4	2.5	0.4	0.5	-1.8	2.5	1.9	2.8	0.7	2.6
Chest pain or discomfort	0.5	0.7	2.0	-0.0	1.0	-1.4	1.4	-0.2	0.9	-0.1	0.5	0.7	0.1
Had major operations	0.3	0.4	1.3	-0.3	-0.3	0.7	-0.9	-0.3	-0.5	-0.4	-0.2	-0.4	-1.2
Age at last live birth	0.3	0.4	1.4	0.1	-0.6	-0.4	-1.2	0.8	-0.5	-0.4	-0.5	-0.2	-0.5
Family relationship satisfaction	0.1	0.1	0.4	-0.3	0.1	0.0	-0.6	-0.0	0.1	0.4	-0.0	0.2	-0.2
Leg pain on walking	0.6	0.8	3.2	-0.5	-0.8	-0.6	0.6	-0.7	-0.9	0.3	-1.2	-1.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	5.0	-2.2	0.1	-0.8	-0.6	-1.4	-0.1	0.7	-0.0	-1.9	-0.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.1	-1.0	1.4	0.6	0.3	-1.2	1.4	1.0	1.5	0.5	1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	6.4	0.3	-0.3	-2.5	0.4	0.7	-0.5	-1.8	-0.6	0.3	-2.0
Medication: Aspirin	0.4	0.6	2.0	0.9	-0.6	0.8	0.7	0.5	-0.6	-1.4	-0.7	0.2	-0.6
Supplements: Vitamin C	0.9	1.1	3.3	0.0	-0.7	-0.8	-0.7	0.9	-0.7	-1.8	-1.5	-0.4	-1.5
Knee pain experienced in last month	2.3	3.6	7.2	-0.8	2.6	0.4	0.9	-1.4	2.7	1.9	2.6	1.6	2.5
Hypertension (Self-reported)	0.9	2.4	6.6	0.2	1.8	0.3	-2.0	0.4	1.9	1.2	1.4	2.6	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	13.0	-1.3	2.5	-3.6	1.2	-1.5	2.3	0.6	1.7	1.7	0.4
Illnesses of father: Heart disease	0.7	1.0	2.4	1.2	-0.8	1.5	-0.7	1.6	-0.7	0.8	-0.1	0.8	-0.7
Illnesses of siblings: Diabetes	0.5	0.6	3.2	0.2	0.0	0.8	-1.8	0.4	0.2	-0.5	1.0	0.2	0.9
Smoking status: Previous	1.6	2.3	6.6	2.5	-0.5	-0.4	0.6	2.6	-0.4	-2.1	0.1	2.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.5	-0.4	-0.1	0.7	1.2	-1.0	-0.1	1.2	0.1	-1.1	0.3
Whole body fat-free mass	1.1	6.2	13.3	-0.2	2.9	0.3	1.2	-0.8	3.1	3.6	2.9	2.6	3.6
Leg fat-free mass (right)	0.9	4.5	11.6	-0.3	2.3	0.3	0.9	-1.0	2.6	3.3	2.4	1.9	3.4
Arm fat percentage (left)	0.5	2.1	9.6	0.9	0.6	0.1	-0.1	0.1	1.0	1.6	2.2	1.2	3.1
Average weekly red wine intake	0.8	1.2	2.1	-1.4	0.1	-1.4	-1.2	-0.9	-0.2	-1.2	-1.1	-0.9	-1.4
Handedness (chirality/laterality): Left-handed	2.2	2.6	5.5	-2.3	2.2	-2.2	0.6	-2.0	2.0	1.0	1.1	0.3	0.5
Mood swings	0.4	0.7	2.6	0.0	0.8	1.1	-0.1	-0.4	0.8	0.6	1.6	0.8	0.5
Loneliness, isolation	0.4	0.5	1.5	-0.0	-0.8	1.2	0.2	-0.2	-0.9	0.3	-0.6	-0.8	-1.0
Long-standing illness, disability or infirmity	0.5	0.8	2.3	-1.0	1.0	1.1	-0.0	-1.5	0.9	0.2	0.5	-0.2	1.2
Ever had bowel cancer screening	0.1	0.2	0.7	0.5	0.1	-0.2	-0.5	-0.1	0.0	0.2	0.3	0.8	-0.5
Diabetes diagnosed by doctor	0.2	0.4	2.0	0.2	-0.1	0.1	-0.7	0.4	0.2	0.4	1.0	-0.1	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.1	0.9	0.7	-0.9	0.6	0.9	0.7	0.5	0.4	1.4	-0.2
Friendships satisfaction	0.6	0.8	5.2	-0.6	0.7	-2.3	0.0	-1.0	0.6	-0.0	-0.0	0.0	-0.2
Qualifications: nursing, teaching	0.9	1.5	2.7	-1.3	-0.9	-1.2	-1.1	-0.5	-1.1	-1.3	-1.3	-1.6	-1.4
Commuting to job workplace: Walk	0.2	0.2	0.9	-0.0	-0.4	0.5	0.1	0.3	-0.2	0.9	-0.1	-0.5	0.9
Eye problems/disorders: Cataract	0.4	0.5	2.0	-0.0	0.3	1.4	-0.8	0.9	0.4	-0.2	0.5	0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.4	1.6	-1.6	-0.3	0.1	1.2	-1.7	-2.0	-2.1	-0.3	-1.3
Medication for cholesterol	0.2	0.3	1.3	0.1	-0.0	-1.2	0.5	0.6	-0.1	-0.1	-0.1	-0.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.7	-1.8	1.3	-0.6	0.6	-1.6	1.2	1.9	1.5	-0.4	1.0
Back pain experienced in last month	0.3	0.5	1.7	0.1	-0.7	1.3	-0.1	-0.1	-0.6	0.9	-0.2	-1.2	0.0
Mineral and other dietary supplements	0.6	0.8	1.9	1.0	0.5	0.4	-0.2	0.7	0.7	1.3	1.1	1.4	0.8
Breast cancer (self-reported)	2.4	2.8	7.3	-0.0	-1.6	-1.6	-1.1	-0.4	-1.9	-2.2	-1.5	-1.9	-2.7
Asthma (self-reported)	0.4	0.9	1.7	-0.5	1.3	0.6	0.9	-1.0	1.2	0.5	1.3	0.5	1.0
Osteoporosis (self-reported)	0.4	0.5	3.2	-0.3	0.2	-1.8	0.6	-0.0	0.1	-1.0	-0.3	-0.1	-0.8
Osteoarthritis (self-reported)	0.4	0.5	1.5	-1.2	0.6	-0.2	-0.9	-0.8	0.5	-0.6	1.1	-0.5	0.0
Medication: Aspirin	0.5	0.6	1.3	1.0	-0.8	1.0	0.4	0.7	-0.8	-1.1	-0.9	0.0	-0.5
Medication: Gliclazide	0.8	0.9	2.9	-0.8	0.9	-0.0	-1.4	-0.3	1.1	0.4	1.0	0.4	1.7
Illnesses of father: None of the above (group 1)	0.6	0.7	3.0	-1.1	-0.3	0.4	-0.5	-1.3	-0.5	-0.6	-0.7	-1.7	-0.2
Smoking status: Current	1.2	1.8	6.5	-1.0	1.7	0.6	-0.2	-0.7	1.7	2.5	1.5	0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	8.4	1.0	-2.8	-0.8	-0.8	1.4	-2.9	-1.7	-2.9	-2.2	-2.0
Whole body water mass	1.2	6.6	14.0	-0.2	3.0	0.3	1.3	-0.8	3.3	3.7	3.0	2.8	3.7
Leg predicted mass (right)	0.9	4.6	11.8	-0.3	2.3	0.3	0.9	-1.0	2.6	3.3	2.4	1.8	3.4
Arm fat mass (left)	1.1	4.7	16.3	0.8	1.8	0.1	0.6	-0.2	2.2	2.8	3.0	2.2	4.0
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	-0.1	1.2	-0.5	-1.3	-0.1	1.2	0.8	1.2	1.1	0.8
Average weekly champagne plus white wine intake	0.8	1.1	2.9	0.8	-1.4	0.7	-0.7	1.7	-1.4	-0.3	-0.9	-0.5	-1.3
Miserableness	0.6	1.1	2.3	1.2	-1.5	1.3	-0.9	0.5	-1.5	-0.8	-0.7	-0.8	-0.8
Guilty feelings	0.6	0.8	2.6	0.9	0.6	0.6	1.0	0.3	0.6	0.9	1.6	1.3	0.4
Wears glasses or contact lenses	2.6	3.0	7.2	1.9	-2.7	0.4	-0.7	1.6	-2.6	-1.6	-1.8	-1.1	-1.4
Ever taken oral contraceptive pill	3.0	3.3	8.0	0.8	-2.8	2.8	-1.3	0.9	-2.7	-0.8	-1.2	-2.1	-0.9
Hearing aid user	0.9	1.0	2.5	-0.2	-1.2	0.9	-0.5	-0.2	-1.3	-0.8	-1.6	-1.4	-1.0
Mother’s age at death	0.5	0.6	2.9	-0.8	-0.4	-1.7	0.5	0.0	-0.3	0.2	-0.7	-1.3	0.3
Financial situation satisfaction	2.2	2.8	6.3	-2.2	2.3	-1.7	1.1	-2.5	2.0	1.2	1.2	0.0	0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.9	0.0	0.8	-1.7	-0.4	0.4	0.7	-1.0	-0.1	1.5	-0.6
Commuting to job workplace: Public transport	4.2	5.0	9.9	1.4	-2.7	0.4	-3.1	2.4	-2.7	-2.0	-2.5	-0.7	-2.6
Eye problems/disorders: Glaucoma	2.4	2.9	7.1	-0.1	2.0	0.2	1.6	-0.7	2.2	1.4	2.7	1.7	2.2
Medication: Blood pressure	0.5	0.9	3.6	0.5	0.4	1.3	-1.9	0.3	0.6	0.0	0.4	1.1	1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	5.1	0.5	0.6	0.7	2.3	0.4	0.7	0.5	1.1	0.9	0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.5	-0.1	-0.7	0.8	1.1	-0.4	-0.7	-1.2	-1.0	-1.2	-0.5
High cholesterol (Self-reported)	0.5	0.9	3.8	1.2	0.8	0.3	-0.1	1.1	0.9	0.1	0.7	2.0	1.0
Medication: Bendroflumethiazide	1.3	2.0	6.2	0.1	1.1	1.9	-0.4	-0.0	1.4	1.3	1.8	1.3	2.5
Medication: Paracetamol	1.0	1.5	3.0	1.3	-1.4	1.7	1.7	1.1	-1.3	-0.5	-1.0	-1.0	-0.1
Medication: Lisinopril	0.9	1.2	2.9	-0.2	1.1	0.1	-0.3	-0.0	1.3	1.6	1.6	0.9	1.7
Medication: Atorvastatin	0.4	0.5	2.5	0.0	-0.2	0.8	-1.6	1.0	-0.1	-0.3	-0.8	0.5	0.2
Illnesses of father: High blood pressure	0.8	1.0	2.6	0.7	0.9	-0.4	0.4	0.4	1.0	1.1	1.4	1.6	1.1
Alcohol drinker status: Never	0.3	0.4	2.4	-0.5	-0.1	1.5	-0.3	-0.3	-0.1	0.6	-0.3	-0.7	-0.5
Ever smoked	0.9	1.7	4.5	2.0	-0.6	0.3	-0.1	2.1	-0.6	-0.9	-0.7	1.7	-1.7
Basal metabolic rate	1.1	6.3	15.0	0.1	2.7	0.4	1.2	-0.6	3.0	3.6	3.0	2.7	3.9
Leg fat percentage (left)	0.7	2.7	8.3	2.0	-0.0	0.6	-0.8	1.8	0.5	1.4	1.8	2.1	2.9
Arm fat-free mass (left)	1.5	7.5	16.5	0.2	3.0	0.3	1.6	-0.4	3.4	3.9	3.2	3.2	4.1
Number of operations (self-reported)	1.0	1.4	5.1	-2.2	1.0	0.5	-0.6	-2.3	0.8	0.9	0.1	-1.1	-0.3
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.6	0.9	0.0	0.3	-0.8	0.8	0.2	0.8	-0.1	0.3
Irritability	0.8	1.3	5.0	1.4	-0.0	0.9	-1.6	1.1	0.1	0.8	0.4	2.2	0.2
Risk taking	0.4	0.6	1.3	-0.6	-0.5	1.1	-1.2	-0.5	-0.6	1.1	0.1	-0.8	-0.6
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.9	-1.8	1.8	-0.2	-1.4	-1.6	1.7	2.0	1.8	0.2	1.1
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.7	-0.2	-0.2	0.5	-0.2	-0.2	0.3	-0.2	0.5	-0.5
Age started oral contraceptive pill	0.3	0.4	1.4	-0.5	-0.7	-0.0	-1.2	-0.1	-0.7	-0.6	-0.1	-1.1	0.1
Diastolic blood pressure, automated reading	0.4	1.2	4.3	2.1	-0.4	1.3	-0.7	1.6	-0.2	0.7	-0.0	1.3	0.9
Ever depressed for a whole week	0.8	1.0	3.0	-1.6	0.5	-1.4	-0.0	-1.7	0.3	-0.0	-0.1	-0.9	-0.9
Unable to work because of sickness or disability	0.6	0.8	1.8	-0.4	1.3	0.5	0.3	-0.5	1.4	0.1	1.2	1.0	1.2
Commuting to job workplace: Cycle	1.4	1.7	4.1	0.5	-1.6	-0.7	0.6	0.5	-1.7	-1.3	-2.0	-1.2	-1.8
Myopia	1.2	1.8	6.2	0.5	-1.4	0.0	-2.5	1.7	-1.3	-0.6	-1.9	-0.6	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.5	-0.1	-1.3	-0.1	1.9	-0.3	-1.4	-0.7	-1.0	-1.7	-1.2
Cholesterol lowering medication	0.4	0.6	2.5	0.5	0.2	1.6	-0.7	0.3	0.4	-0.4	0.6	1.0	0.9
Medication: Omeprazole (e.g. Zanprol)	5.2	6.3	12.2	-2.7	3.4	-0.1	-0.2	-1.9	3.5	2.4	3.5	1.0	3.1
Pain experienced in last month	0.5	0.9	3.3	-0.3	-1.4	-0.3	-0.4	-0.0	-1.4	-0.1	-1.1	-1.8	-0.6
Supplements: Calcium	0.1	0.1	0.2	-0.0	0.4	-0.4	-0.1	-0.3	0.3	-0.5	-0.1	0.3	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.0	1.0	-0.3	0.6	-0.3	0.2	-0.4	-0.1	0.3	0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.8	1.2	-0.4	-0.3	-0.8	1.3	-0.1	0.7	-0.5	0.5	1.3
Deep venous thrombosis (DVT) (self-reported)	2.5	3.3	7.2	-1.5	2.6	-0.6	-0.3	-1.0	2.6	1.4	2.7	1.7	1.7
Heart disease (siblings)	2.4	2.9	8.2	1.2	-1.8	1.8	-2.9	1.9	-1.8	-1.3	-1.5	-0.0	-1.5
Alcohol drinker status: Previous	0.4	0.5	1.8	1.3	-0.0	0.5	0.3	1.0	0.1	-0.6	0.4	1.0	0.6
Pack years of smoking	1.8	2.7	8.8	-0.7	1.7	0.4	-0.1	-1.3	1.8	1.8	3.0	0.9	2.4
Impedance of whole body	0.6	2.9	8.3	1.0	-2.0	-0.1	-0.1	1.4	-2.1	-2.9	-1.7	-1.0	-2.3
Leg fat mass (left)	1.0	4.0	14.5	1.4	1.1	0.8	-0.1	0.8	1.6	2.4	2.5	2.5	3.8
Arm predicted mass (left)	1.6	7.9	17.1	0.1	3.2	0.3	1.7	-0.5	3.5	3.8	3.3	3.3	4.1