TWAS hub - ACTA2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0407	0.0149	0.00089	0.040	0.008	0.033	0.030	0.037	6.1e-13	1.2e-03	5.9e-11	4.3e-10	4.9e-12
2	YFS	Blood	0.7145	0.0213	0.00000	0.691	0.685	0.718	0.694	0.713	0.0e+00	2.1e-318	0.0e+00	0.0e+00	0.0e+00
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1820	0.1020	0.00790	-0.005	0.010	0.021	NA	0.005	8.3e-01	8.7e-02	2.2e-02	NA	1.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hypothyroidism (self reported)	7.7	17.6	19.5	-4.4	-4.4	-3.7
Hypothyroidism/myxoedema (self-reported)	6.9	13.5	15.4	-3.7	-3.9	-3.4
Townsend deprivation index at recruitment	5.4	7.6	8.2	2.8	2.9	2.5
Prostate Cancer	4.9	6.9	12.1	-2.0	-2.2	-3.5
Pack years adult smoking proportion	4.7	7.2	9.7	2.4	2.5	3.1
Bilateral oophorectomy (both ovaries removed)	4.2	4.9	5.9	-2.4	-2.3	-1.8
Alcohol usually taken with meals	4.0	6.5	8.6	-2.7	-2.9	-1.9
Blood Red Count	3.8	36.4	49.3	-6.9	-7.0	-3.5
Pack years of smoking	3.5	5.2	6.8	2.1	2.1	2.6
Illnesses of siblings: Diabetes	3.0	3.7	4.3	1.9	1.8	2.1
Happiness	2.9	3.5	5.7	2.2	2.4	0.2
Illnesses of father: High blood pressure	2.8	3.5	5.2	-2.3	-2.2	-0.6
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	4.3	1.7	1.8	2.1
Ever had hysterectomy (womb removed)	2.5	2.8	4.6	-2.0	-2.1	-0.1
Blood clot in the leg (DVT)	2.4	3.1	3.6	1.9	1.9	1.5
Age at last live birth	2.4	3.5	4.3	-1.6	-1.9	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	3.8	-1.5	-1.9	-1.3
Alcohol intake versus 10 years previously	2.3	3.5	4.8	1.8	2.2	1.6
Medication: Gliclazide	2.1	2.4	3.8	-1.7	-1.9	-0.6
Pain type(s) experienced in last month: Hip pain	2.1	2.6	4.4	1.8	2.1	-0.1
Mineral and other dietary supplements	2.0	2.7	3.5	1.5	1.9	1.5
Blood White Count	1.9	14.0	16.5	3.7	4.1	3.4
Medication: Levothyroxine sodium	1.9	3.3	5.6	-2.0	-2.4	-0.6
Number of full brothers	1.9	2.4	4.6	1.2	1.1	2.1
Commuting to job workplace: Cycle	1.9	2.3	2.9	1.6	1.7	1.2
Rheumatoid Arthritis	1.8	2.4	3.1	-1.4	-1.5	-1.8
Blood Eosinophil Count	1.8	14.0	22.7	4.2	4.8	1.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	2.9	1.7	1.6	1.2
Reaction Time	1.7	3.3	7.4	0.8	1.3	2.7
Health satisfaction	1.7	2.2	3.2	1.4	1.8	1.1
Osteoarthritis (self-reported)	1.7	2.3	2.6	1.6	1.6	1.2
Medication: Lisinopril	1.7	2.2	6.5	0.1	0.1	-2.6
HbA1C	1.6	1.8	2.7	1.6	1.6	0.6
Fed-up feelings	1.6	2.8	4.6	2.1	1.9	0.4
Average weekly red wine intake	1.6	2.4	3.9	-1.3	-1.3	-2.0
Coronary Artery Disease (CAD)	1.5	1.7	3.1	1.8	1.4	0.3
Average weekly spirits intake	1.5	1.8	2.2	1.2	1.3	1.5
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.1	-1.3	-1.8	-1.0
Diabetes (mother)	1.5	1.9	2.3	1.5	1.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	2.5	1.6	1.5	-0.6
Illnesses of father: None of the above (group 1)	1.5	1.8	3.4	0.7	1.2	1.9
HDL Cholesterol	1.4	2.3	5.5	-0.9	-0.7	-2.3
Serious illness, injury or assault to yourself	1.4	1.7	2.0	-1.3	-1.2	-1.4
Chronic bronchitis/emphysema (father)	1.4	1.7	2.0	-1.0	-1.4	-1.4
Hair/balding pattern: Pattern 2	1.4	1.8	2.0	1.4	1.2	1.4
Chest pain or discomfort	1.4	2.0	2.6	1.3	1.3	1.6
Family relationship satisfaction	1.4	1.7	2.8	1.5	1.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.7	-1.6	-1.4	0.7
Heart disease (siblings)	1.4	1.7	3.3	1.1	0.8	1.8
Bipolar Disorder (2011)	1.3	1.2	1.9	-1.3	-1.4	0.0
Mouth/teeth dental problems	1.3	2.0	2.6	-1.6	-1.5	-1.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.6	-0.4	-0.7	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	3.0	1.1	1.3	1.7
Smoking status: Current	1.3	2.0	2.5	1.1	1.5	1.6
Major Depression (MDD)	1.2	1.5	2.9	-0.9	-0.9	-1.7
Primary Biliary Cirrhosis	1.2	1.7	2.0	-1.4	-1.4	-1.1
Hayfever, allergic rhinitis or eczema	1.2	2.7	8.0	-0.0	-0.1	-2.8
Stomach or abdominal pain in last month	1.2	1.5	3.4	0.8	0.8	1.9
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.3	0.3	0.0	2.1
Long-standing illness, disability or infirmity	1.2	1.8	2.5	1.6	1.6	-0.5
Medication: Atorvastatin	1.2	1.5	1.8	-1.1	-1.2	-1.3
Current tobacco smoking	1.1	1.9	2.6	1.1	1.6	1.3
Supplements: Glucosamine	1.1	1.4	2.3	-1.0	-1.0	-1.5
Father’s age at death	1.1	1.5	3.2	-0.6	-0.9	-1.8
Pain experienced in last month	1.1	1.8	2.8	-1.7	-1.6	-0.3
Ovarian Cancer	1.0	1.3	2.7	-0.9	-0.7	-1.6
Supplements: Zinc	1.0	1.1	2.8	0.3	0.5	1.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.3	-1.2	-1.1	-0.8
Nervous feelings	1.0	1.8	3.0	1.7	1.4	-0.6
Headache pain in last month	1.0	1.7	4.4	-0.7	-0.4	-2.1
High blood pressure (siblings)	1.0	1.5	1.6	-1.1	-1.2	-1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.1	1.6	1.1	1.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.4	1.2	0.9	1.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.4	-1.1	-1.5	-0.6
Schizophrenia (2018)	0.9	1.9	2.5	-1.4	-1.6	-1.1
Blood Platelet Count	0.9	10.0	12.1	3.3	3.5	2.6
Falls in the last year	0.9	1.2	1.6	-1.2	-1.3	-0.8
Qualifications: College or University degree	0.9	2.7	4.0	1.9	2.0	0.6
Loneliness, isolation	0.9	1.3	2.0	1.4	1.3	-0.2
Medication for cholesterol	0.9	1.4	2.0	-1.4	-1.1	-1.0
Bipolar Disorder or Schizophrenia	0.8	1.9	2.2	-1.4	-1.5	-1.2
Allergy or Eczema	0.8	2.2	6.5	-0.0	-0.1	-2.5
Medication: Ramipril	0.8	1.0	1.3	1.0	0.9	1.1
Illnesses of mother	0.8	1.0	1.3	-1.0	-0.8	-1.1
Neck or shoulder pain in last month	0.8	1.2	2.0	-0.8	-1.0	-1.4
Smoking status: Previous	0.8	1.2	1.9	-1.0	-0.9	-1.4
Qualifications: nursing, teaching	0.8	1.2	2.3	-0.8	-0.8	-1.5
Ever smoked	0.8	1.5	2.3	-1.1	-1.0	-1.5
Alzheimer’s Disease (including proxy)	0.7	1.1	2.0	-1.4	-1.1	0.3
Lupus	0.7	1.0	1.3	-1.1	-0.9	-1.0
Sensitivity / hurt feelings	0.7	1.2	1.7	1.3	1.1	0.8
Medication: Atenolol	0.7	0.9	2.7	0.3	-0.1	-1.6
High blood pressure (mother)	0.7	1.0	1.6	1.3	1.1	0.6
Number of live births	0.7	1.0	1.9	-1.1	-1.4	-0.3
Forced vital capacity (FVC), Best measure	0.7	2.4	7.2	0.0	-0.2	-2.7
Exposure to tobacco smoke outside home	0.7	0.9	2.7	-0.1	0.1	1.6
Pulse rate, automated reading	0.7	2.1	3.3	-1.8	-1.7	0.3
Had major operations	0.7	0.9	1.0	0.9	0.9	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	-1.2	-0.9	-0.5
Unable to work because of sickness or disability	0.7	0.9	1.7	-0.8	-0.7	-1.3
Alcohol drinker status: Previous	0.7	0.8	1.4	-0.9	-1.2	-0.2
Alzheimer’s Disease (in mother)	0.6	0.8	1.1	-1.0	-1.1	-0.3
Ulcerative Colitis (UC)	0.6	1.1	1.5	1.2	0.8	-1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	1.8	1.3	1.2	-1.0
Age at First Birth	0.6	0.9	1.3	0.9	0.8	-1.1
Fasting Glucose	0.6	0.7	1.1	-1.0	-0.9	-0.4
Ulcerative Colitis	0.6	0.9	1.9	0.7	0.7	-1.4
Lung FVC	0.6	3.2	8.7	-0.6	-0.7	-3.0
Hearing difficulty/problems: Yes	0.6	1.0	1.7	0.7	0.8	1.3
Qualifications: CSEs or equivalent	0.6	0.8	0.9	1.0	1.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-0.6	-0.6	1.2
Forced vital capacity (FVC)	0.6	2.2	6.5	0.1	0.0	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.0	0.6	0.9	-1.0
Pulse wave reflection index	0.6	0.7	1.2	-1.1	-0.8	-0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.4	-0.0	-0.2	-1.6
Glaucoma (self-reported)	0.6	0.7	0.9	0.8	0.7	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	0.2	0.0	1.4
Mean time to correctly identify matches	0.6	1.2	3.2	0.2	0.5	1.8
Average weekly champagne plus white wine intake	0.6	0.9	2.5	0.1	0.4	1.6
Irritability	0.6	1.0	1.6	1.3	1.0	0.5
Crohns Disease (2017)	0.5	1.0	1.5	-0.5	-1.2	-1.2
Triglycerides	0.5	0.9	1.2	-0.9	-1.1	-0.8
Neuroticism	0.5	1.3	1.7	1.3	1.2	0.8
Fluid intelligence score	0.5	1.1	1.9	1.4	1.2	0.3
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	0.5	0.3	1.4
Length of working week for main job	0.5	0.6	1.1	1.1	0.7	-0.3
Exposure to tobacco smoke at home	0.5	0.6	0.8	0.7	0.9	0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.9	-0.0	0.0	-1.4
Eye problems/disorders: None of the above	0.5	0.5	0.6	-0.7	-0.8	0.6
Medication: Seretide 50 evohaler	0.5	0.6	0.8	-0.9	-0.9	0.2
Overall health rating	0.5	1.0	1.2	1.0	0.9	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	-0.1	-0.4	-1.3
Eye problems/disorders: Cataract	0.5	0.6	1.0	0.7	1.0	-0.5
Breast cancer (self-reported)	0.5	0.6	1.0	-0.6	-1.0	-0.5
Hearing aid user	0.5	0.6	0.6	-0.8	-0.7	0.7
Financial situation satisfaction	0.5	0.6	0.9	0.9	0.9	0.4
Medication: Paracetamol	0.5	0.8	1.4	-1.2	-0.9	-0.4
Breast Cancer	0.4	0.8	1.6	-0.7	-0.7	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	0.5	0.6	-0.8
Severe depression (siblings)	0.4	0.4	0.5	-0.6	-0.7	0.6
Impedance of leg (right)	0.4	1.8	2.5	-1.2	-1.2	-1.6
Sitting height	0.4	3.0	3.4	1.7	1.6	-1.8
Medication: Cholesterol lowering	0.4	0.6	1.1	-0.8	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	3.4	0.1	-0.1	-1.8
Medication: Amlodipine	0.4	0.6	0.8	0.9	0.4	0.9
Birth weight	0.4	0.8	1.4	1.2	1.0	-0.2
Arm fat-free mass (right)	0.4	1.8	2.6	1.6	1.5	-0.8
Worry too long after embarrassment	0.4	0.6	1.0	1.0	0.8	0.5
Age at first live birth	0.4	0.7	2.1	0.2	0.2	-1.4
Heart disease (mother)	0.4	0.4	0.6	0.8	0.6	0.6
Arm predicted mass (right)	0.4	2.0	3.0	1.7	1.6	-0.7
Comparative height size at age 10	0.4	1.9	3.0	1.7	1.6	0.7
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.8	-0.9	0.1
Whole body fat-free mass	0.4	2.1	3.2	1.8	1.7	-0.2
Back pain experienced in last month	0.4	0.6	0.9	1.0	1.0	0.2
Whole body water mass	0.4	2.2	3.5	1.9	1.8	-0.1
Wears glasses or contact lenses	0.4	0.4	0.9	0.3	0.5	0.9
Ever taken oral contraceptive pill	0.4	0.5	1.4	-0.1	0.2	-1.2
High cholesterol (Self-reported)	0.4	0.6	1.3	-0.7	-1.1	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.5	-0.6	-0.7	0.7
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	0.6	-0.1	-1.4
Crohns Disease (2012)	0.3	0.4	1.1	-0.0	-0.4	-1.1
Mean Putamen Volume	0.3	0.4	0.5	-0.7	-0.7	-0.0
Smoking Status	0.3	0.6	0.8	0.6	0.9	0.8
Respiratory disease	0.3	0.6	1.9	0.0	0.0	-1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.7	0.9	0.3
Medication: Co-codamol	0.3	0.3	0.8	0.3	0.4	0.9
Medication: Metformin	0.3	0.4	0.4	-0.7	-0.7	0.6
Leg fat-free mass (left)	0.3	1.5	2.5	1.6	1.4	0.0
Leg predicted mass (left)	0.3	1.4	2.4	1.5	1.3	-0.0
Past tobacco smoking	0.3	0.6	1.1	0.6	0.5	1.0
Had menopause	0.3	0.4	0.7	-0.2	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.7	-0.5	-0.8
Allergy	0.3	0.7	1.2	-0.6	-0.7	1.1
Illnesses of siblings	0.3	0.4	0.4	-0.7	-0.6	-0.6
Neuroticism score	0.3	0.7	1.2	1.1	0.9	-0.1
Trunk fat-free mass	0.3	1.8	2.6	1.6	1.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.4	0.4	0.2	-1.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.8	-0.1	-0.2	-1.4
Medication: Lansoprazole	0.3	0.3	0.9	0.2	0.2	0.9
Impedance of arm (left)	0.3	1.6	2.3	-1.4	-1.5	-0.8
Trunk predicted mass	0.3	1.7	2.6	1.6	1.6	-0.3
Breastfed as a baby	0.3	0.4	1.1	-0.0	-0.3	1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	-0.4	-0.2	-0.8
Gout (self-reported)	0.3	0.5	1.0	0.6	0.2	-1.0
Comparative body size at age 10	0.3	0.8	1.0	-0.9	-0.7	-1.0
Medication: Ibuprofen	0.3	0.3	0.5	-0.7	-0.5	-0.6
Suffer from ‘nerves’	0.3	0.5	0.6	-0.7	-0.6	-0.8
Medication: Aspirin	0.3	0.4	1.0	-0.3	-0.4	1.0
Leg fat-free mass (right)	0.3	1.8	2.9	1.7	1.6	0.3
Ever had bowel cancer screening	0.3	0.4	0.7	0.8	0.5	-0.4
Medication: Aspirin	0.3	0.5	0.5	-0.7	-0.6	0.7
Leg predicted mass (right)	0.3	1.7	2.7	1.6	1.5	0.3
Miserableness	0.3	0.5	0.9	0.9	0.7	-0.3
Mother’s age at death	0.3	0.4	0.6	0.8	0.7	0.3
Commuting to job workplace: Public transport	0.3	0.4	1.2	-0.0	-0.0	-1.1
Basal metabolic rate	0.3	1.7	2.8	1.7	1.5	-0.1
Arm fat-free mass (left)	0.3	1.5	2.6	1.6	1.4	-0.3
Ever depressed for a whole week	0.3	0.4	0.9	-0.4	-0.2	-0.9
Impedance of whole body	0.3	1.7	2.1	-1.4	-1.4	-1.1
Arm predicted mass (left)	0.3	1.6	2.8	1.7	1.5	0.0
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	0.9	0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.4	1.2	0.8	-0.5
Worry (Nagel 2018)	0.2	0.4	1.3	0.1	-0.1	-1.1
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.3	-0.3	0.7
LDL Cholesterol	0.2	0.3	0.7	-0.2	-0.2	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.8	-0.3	0.0
Lung FEV1/FVC ratio	0.2	0.8	2.2	0.3	0.4	1.5
Hand grip strength (left)	0.2	0.6	1.0	0.7	0.6	-1.0
Diabetes (father)	0.2	0.2	0.5	-0.0	-0.4	0.7
Average weekly fortified wine intake	0.2	0.2	0.4	-0.4	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.6	0.7	-0.2
Impedance of leg (left)	0.2	0.9	1.2	-1.1	-1.0	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	-0.9	-0.8	0.0
Medication: Simvastatin	0.2	0.2	0.5	0.4	-0.0	0.7
Impedance of arm (right)	0.2	1.1	1.8	-1.2	-1.4	-0.2
Hip circumference	0.2	0.7	1.0	1.0	0.7	0.7
Time employed in main current job	0.2	0.3	0.7	-0.1	-0.2	-0.9
Worrier / anxious feelings	0.2	0.3	0.5	0.6	0.4	-0.7
Noisy workplace	0.2	0.3	0.5	-0.7	-0.6	0.0
Depression (self-reported)	0.2	0.2	0.4	0.3	0.3	0.6
Standing height	0.2	1.9	3.5	1.0	1.0	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	-0.7	-0.6	-0.5
Medication: Paracetamol	0.2	0.4	0.7	-0.8	-0.6	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.5	-0.1	-0.8
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	-0.3	-0.2	-1.0
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	0.6	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.0	0.1	0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	0.5	0.4	-0.6
Medication: Blood pressure	0.2	0.3	0.7	0.8	0.4	0.1
Angina (self-reported)	0.2	0.3	0.6	-0.6	-0.8	-0.1
Medication: Allopurinol	0.2	0.3	0.6	0.8	0.5	0.2
Number of full sisters	0.2	0.3	0.5	0.3	0.4	0.7
Supplements: Vitamin C	0.2	0.2	0.7	0.1	-0.2	0.8
Friendships satisfaction	0.2	0.3	0.5	0.4	0.4	0.7
Asthma (self-reported)	0.2	0.3	0.7	0.4	0.4	-0.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	0.7	0.6	-0.4
Guilty feelings	0.2	0.4	0.7	0.5	0.3	0.9
Alcohol drinker status: Never	0.2	0.3	0.6	0.4	0.2	0.8
Average weekly beer plus cider intake	0.2	0.3	0.5	0.7	0.7	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.0	0.0	-0.9
Supplements: Calcium	0.2	0.2	0.3	0.5	0.5	0.0
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.5	-0.4	-0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.6	0.7	0.4	-0.1
Neuroticism (2016)	0.1	0.1	0.2	0.5	0.4	0.2
Heel T-Score	0.1	0.7	1.2	-0.9	-1.1	0.0
Height	0.1	1.5	1.9	-1.2	-1.1	-1.4
Waist Hip Ratio (WHR)	0.1	0.3	0.7	-0.3	0.0	0.8
Systolic Blood Pressure	0.1	0.7	1.2	0.6	0.7	1.1
Cardiovascular Disease	0.1	0.2	0.4	0.7	0.3	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.2	-0.4	-0.4
Chronotype (morning person)	0.1	0.1	0.4	0.0	-0.1	0.6
Number of treatments/medications taken	0.1	0.3	0.4	-0.4	-0.6	-0.5
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.1	-0.0	0.7
Angina	0.1	0.2	0.3	-0.4	-0.6	0.2
Vitamin and mineral supplements	0.1	0.2	0.6	-0.1	0.0	-0.7
Maternal smoking around birth	0.1	0.1	0.1	0.2	0.4	-0.1
Taking other prescription medications	0.1	0.2	0.6	-0.2	0.1	0.8
Age when periods started (menarche)	0.1	0.3	0.4	-0.5	-0.6	-0.5
Multivitamins +/- minerals	0.1	0.1	0.3	-0.0	0.1	0.5
Body mass index (BMI)	0.1	0.3	0.6	0.6	0.3	0.8
Trunk fat mass	0.1	0.3	0.6	0.8	0.4	0.2
Waist circumference	0.1	0.3	0.9	-0.1	-0.1	0.9
Number of incorrect matches in round	0.1	0.2	0.3	-0.1	-0.3	0.6
Had other major operations	0.1	0.2	0.4	-0.3	-0.6	-0.0
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.6	-0.3	0.1
Pain all over the body in last month	0.1	0.1	0.4	-0.0	-0.0	-0.7
Weight	0.1	0.5	1.0	1.0	0.7	-0.1
Arm fat percentage (right)	0.1	0.3	0.6	-0.1	-0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.3	0.2	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.3	0.4	-0.6
Pulse rate	0.1	0.2	0.3	-0.3	-0.5	-0.4
Asthma	0.1	0.2	0.3	0.4	0.5	-0.6
Prospective memory result	0.1	0.1	0.1	-0.3	-0.3	0.1
Lung cancer (father)	0.1	0.2	0.3	-0.2	-0.3	-0.5
Arm fat mass (right)	0.1	0.2	0.5	0.4	0.1	0.7
Tense / ‘highly strung’	0.1	0.2	0.4	0.6	0.5	-0.0
Birth weight of first child	0.1	0.2	0.5	0.3	-0.1	-0.7
Peak expiratory flow (PEF)	0.1	0.1	0.2	0.5	-0.0	-0.4
Loud music exposure frequency	0.1	0.1	0.1	-0.2	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.6	0.5	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	-0.1	0.4
Alcohol intake frequency.	0.1	0.2	0.3	0.5	0.5	0.5
Knee pain experienced in last month	0.1	0.2	0.5	-0.2	-0.4	-0.7
Hypertension (Self-reported)	0.1	0.2	0.4	0.1	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	0.4	0.6	-0.5
Mood swings	0.1	0.1	0.2	0.4	0.3	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.3	0.2	0.7
Commuting to job workplace: Walk	0.1	0.1	0.2	0.2	0.3	0.5
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.0	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.2	-0.5	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.2	0.3	0.4	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	-0.1	-0.2	0.4
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.1	-0.5	0.4
Leg fat percentage (left)	0.1	0.2	0.5	-0.1	-0.2	0.7
Number of operations (self-reported)	0.1	0.1	0.4	0.6	0.1	-0.0
Risk taking	0.1	0.1	0.2	0.1	0.4	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.4	-0.7	-0.5	0.2
Myopia	0.1	0.2	0.4	0.3	0.7	0.2
Cholesterol lowering medication	0.1	0.2	0.4	0.7	0.3	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.0	-0.1	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.1	-0.3	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	0.2	0.3	0.3
Depression (Nagel 2018)	0.0	0.0	0.0	0.1	0.1	-0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.2	-0.2	-0.0
Schizophrenia (2014)	0.0	0.1	0.2	-0.3	-0.5	-0.1
BMI	0.0	0.2	0.6	-0.3	-0.8	-0.2
Hair Pigment	0.0	1.3	1.5	-1.2	-1.2	-1.0
Tanning	0.0	0.1	0.1	-0.4	0.2	-0.2
Relative age of first facial hair	0.0	0.1	0.1	0.1	0.2	0.4
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	-0.1	0.1
Trunk fat percentage	0.0	0.1	0.1	0.3	-0.2	0.3
Hand grip strength (right)	0.0	0.1	0.2	0.1	0.3	-0.5
Relative age voice broke	0.0	0.1	0.1	0.2	-0.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	-0.2	-0.1	0.5
High blood pressure	0.0	0.1	0.1	0.2	0.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.1	-0.1	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.1	-0.3	0.2
Qualifications: None of the above	0.0	0.0	0.1	-0.1	-0.2	-0.3
Heart attack	0.0	0.1	0.2	0.0	0.1	0.4
Diabetes (self-reported)	0.0	0.0	0.1	-0.1	-0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.0	0.2	0.1
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	0.2	0.2	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.1	-0.4	0.3
Body fat percentage	0.0	0.1	0.1	0.1	-0.3	0.3
Leg fat percentage (right)	0.0	0.0	0.1	-0.1	-0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.1	0.3	-0.0
Number of children fathered	0.0	0.0	0.1	-0.2	-0.2	0.1
Pulse wave peak to peak time	0.0	0.0	0.1	0.1	0.0	-0.2
Migraine (self-reported)	0.0	0.0	0.1	-0.0	0.2	0.3
Medication: Omeprazole	0.0	0.0	0.1	-0.2	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.0	0.1	0.3
Whole body fat mass	0.0	0.1	0.3	0.5	0.1	0.2
Leg fat mass (right)	0.0	0.0	0.0	0.2	-0.1	0.1
Leg pain on walking	0.0	0.0	0.1	0.1	-0.3	-0.0
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	-0.1	-0.2
Arm fat percentage (left)	0.0	0.2	0.3	-0.2	-0.6	0.4
Arm fat mass (left)	0.0	0.1	0.1	0.3	-0.1	0.2
Medication: Blood pressure	0.0	0.0	0.1	0.4	0.1	-0.0
Age started oral contraceptive pill	0.0	0.0	0.0	-0.1	-0.1	-0.0
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	-0.2	0.1	0.2
Leg fat mass (left)	0.0	0.0	0.1	0.1	-0.1	0.3

Hub : Genes

ACTA2

Models

Trait associations