Hub : Genes

RAB40B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.3273	0.0912	6.4e-07	0.299	NA	0.243	NA	0.275	2.5e-16	NA	3.7e-13	NA	5.4e-15
2	GTEx	Muscle Skeletal	0.4400	0.1048	2.9e-10	0.133	NA	0.100	NA	0.128	5.5e-13	NA	5.0e-10	NA	1.6e-12
3	GTEx	Nerve Tibial	0.2109	0.0629	5.1e-04	0.026	NA	0.084	NA	0.054	5.5e-03	NA	1.4e-06	NA	1.0e-04
4	GTEx	Ovary	0.3120	0.1120	5.1e-03	-0.010	NA	0.039	NA	0.000	6.9e-01	NA	4.1e-02	NA	3.1e-01
5	GTEx	Thyroid	0.4150	0.0840	1.4e-10	0.180	NA	0.243	NA	0.234	9.1e-14	NA	1.4e-18	NA	7.2e-18
6	TCGA	Breast Invasive Carcinoma	0.0263	0.0131	5.1e-03	0.013	0.011	0.010	NA	0.009	9.0e-04	2.0e-03	2.7e-03	NA	5.4e-03
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0361	0.0195	6.8e-03	0.035	0.017	0.022	NA	0.022	6.8e-05	4.4e-03	1.4e-03	NA	1.4e-03
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1800	0.1030	9.4e-03	0.002	0.007	0.019	NA	0.004	2.3e-01	1.2e-01	2.7e-02	NA	1.8e-01
9	TCGA	Lung Squamous Cell Carcinoma	0.0447	0.0228	3.6e-03	0.017	0.012	0.010	NA	0.012	4.7e-03	1.3e-02	2.6e-02	NA	1.4e-02
10	TCGA	Prostate Adenocarcinoma	0.0587	0.0262	2.6e-03	0.027	0.014	0.020	NA	0.015	7.2e-04	1.3e-02	3.3e-03	NA	8.4e-03
11	TCGA	Thyroid Carcinoma	0.2340	0.0570	0.0e+00	0.176	0.188	0.230	NA	0.235	8.0e-17	5.1e-18	3.9e-22	NA	1.1e-22

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.2	0.5	0.0	-0.5	0.5	0.4	-0.5	0.3	-0.6	-0.7	0.2	0.1	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	0.0	-0.7	-1.1	1.2	-0.2	0.6	0.1	-1.0	-1.0	0.6	0.2
Depressed Affect (Nagel 2018)	0.5	1.0	6.7	-0.7	-0.6	0.3	-0.8	-0.3	1.5	0.2	0.4	0.2	2.6	-0.1
Depression (Nagel 2018)	0.6	0.9	3.3	-1.0	-0.5	-0.7	-0.1	0.1	1.8	1.3	-0.1	0.0	1.6	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.9	-0.2	0.2	0.2	-1.7	-0.4	0.1	-0.2	-0.2	-0.7	-2.2	-0.2
Neuroticism (Nagel 2018)	0.4	0.9	5.9	-0.5	-0.5	-0.3	-1.3	-0.4	1.2	-0.1	-0.4	-0.8	2.4	-0.2
Schizophrenia (2018)	0.4	0.8	3.2	0.0	-0.6	-1.8	1.2	0.1	0.4	0.6	-0.2	-1.5	0.7	0.8
Schizophrenia vs Biploar Disorder	1.7	2.2	4.2	0.0	1.6	-1.9	-0.9	1.9	1.7	2.0	1.2	-1.2	0.1	2.0
Worry (Nagel 2018)	0.4	0.9	2.9	0.1	0.4	-1.1	-1.7	0.2	1.5	0.3	-0.7	-1.3	1.0	0.3
Alzheimer’s Disease (in mother)	2.1	2.5	4.7	-1.5	-2.2	0.8	0.7	-2.1	-0.9	-2.0	-0.6	1.4	1.9	-1.9
Alzheimer’s Disease (in father)	0.9	1.0	4.1	0.6	0.5	-2.0	0.6	0.6	-1.3	0.5	0.3	-1.5	-0.7	0.9
Alzheimer’s Disease (including proxy)	0.9	1.3	5.0	-0.6	-1.3	-0.2	0.6	-1.3	-2.2	-1.4	-0.9	-0.0	1.0	-1.1
Crohns Disease (2017)	0.6	1.4	7.4	0.4	0.3	2.7	-1.3	-0.1	-0.1	0.4	0.3	0.3	-2.3	-0.0
Irritable Bowel Disease (IBD)	0.4	0.9	2.4	0.6	0.8	1.5	-0.2	0.4	1.2	1.5	1.2	0.2	-1.2	0.5
Ulcerative Colitis (UC)	0.7	1.3	2.9	1.4	1.7	-0.6	0.2	1.0	1.4	1.4	1.7	0.4	0.0	1.1
Major Depression (MDD)	2.3	2.7	7.2	-2.4	-2.2	0.1	0.7	-2.7	-0.5	-1.9	-0.9	-0.4	0.0	-2.7
Reaction Time	0.2	0.3	0.8	-0.7	-0.7	0.5	0.9	-0.6	-0.5	-0.4	0.6	-0.4	-0.1	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	5.6	-0.5	-0.0	0.4	-0.6	-0.4	0.7	0.3	0.1	-2.4	-0.9	-0.1
Breast Cancer	1.7	4.2	13.6	-1.8	-2.5	1.1	1.4	-2.9	-1.8	-3.7	-0.4	-0.1	0.8	-2.7
Ovarian Cancer	1.1	1.4	3.0	1.7	1.7	-0.9	0.6	1.6	0.3	0.9	1.0	-0.6	-0.8	1.6
Prostate Cancer	0.4	0.5	1.5	0.2	-0.0	0.3	-1.2	-0.6	-1.1	0.2	0.4	-0.9	-1.2	-0.0
Age at First Birth	0.5	0.7	3.2	-0.1	-0.0	-0.1	-1.8	-0.8	-0.6	-0.9	-1.1	0.8	-0.3	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.1	0.1	0.4	-0.8	0.2	1.0	0.2	1.1	-1.0	-1.1	-0.2	0.8
Coronary Artery Disease (CAD)	0.4	0.5	2.1	0.0	0.7	0.5	0.4	0.4	0.4	0.1	1.3	0.7	-1.4	-0.2
Crohns Disease (2012)	1.3	2.0	13.1	0.1	0.2	2.4	-0.7	-0.5	-0.9	-0.5	1.3	-0.0	-3.6	-0.4
Mean Putamen Volume	1.2	1.4	4.5	-1.6	-1.6	1.0	1.0	-0.7	0.2	0.1	-1.5	-0.5	2.1	-0.9
Fasting Glucose	2.3	2.8	7.1	1.3	2.0	-1.8	-1.2	2.0	1.9	2.7	0.9	-0.1	0.9	2.0
HbA1C	2.1	2.4	12.6	0.0	-0.1	-0.0	0.6	-0.6	1.6	-2.1	1.0	3.5	-1.6	-1.5
HDL Cholesterol	1.0	1.7	3.6	-1.7	-1.8	1.0	0.1	-1.9	0.4	-1.7	0.1	-0.1	0.9	-1.9
LDL Cholesterol	0.7	1.1	3.0	1.0	1.0	-0.6	1.1	1.7	-0.1	1.5	-0.1	-0.3	-0.8	1.5
Lupus	0.4	0.7	3.6	0.4	0.4	0.8	-1.9	-0.3	-0.9	0.1	0.0	0.7	-1.2	-0.2
Neuroticism (2016)	0.5	0.7	2.5	-0.2	0.0	-1.4	-1.6	0.6	0.2	0.7	-1.3	-0.4	0.4	0.4
Primary Biliary Cirrhosis	1.3	1.8	4.1	1.1	1.3	-2.0	0.6	1.8	1.1	1.8	1.1	-0.5	-0.1	1.8
Rheumatoid Arthritis	0.2	0.3	1.2	0.1	0.3	0.3	-0.4	0.5	-0.5	1.1	0.6	0.6	-0.6	0.6
Schizophrenia (2014)	0.6	1.4	3.8	0.0	0.3	-2.0	0.9	1.1	0.5	1.7	-0.0	-1.5	0.3	2.0
Triglycerides	0.3	0.5	1.9	0.7	0.7	-0.7	0.4	0.8	0.0	0.4	0.1	-0.3	1.4	0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.7	0.0	1.1	-1.2	-1.6	0.4	-0.9	-0.5	-0.9	0.4	-0.9	0.3
Ulcerative Colitis	0.5	0.8	2.8	0.0	1.2	-0.3	0.4	0.7	0.9	1.0	1.7	0.0	-1.3	0.6
Blood Eosinophil Count	0.2	1.3	8.7	-0.5	-0.2	1.1	-0.8	-0.9	-0.0	-1.2	-0.4	3.0	0.4	-1.0
Blood Platelet Count	0.9	10.0	16.7	-4.1	-3.9	2.8	3.3	-3.0	-2.2	-3.4	-4.1	-0.2	-1.4	-4.0
Blood Red Count	0.9	8.5	32.8	2.1	2.8	0.8	-5.7	2.5	1.7	2.8	3.9	-1.6	-2.0	2.9
Blood White Count	0.1	0.9	4.4	0.2	0.2	-0.8	1.5	0.2	-1.1	-0.2	1.1	0.5	-2.1	0.2
Heel T-Score	0.1	0.5	1.8	0.3	0.2	0.9	-1.3	-0.3	-1.0	0.3	1.2	-0.1	-0.8	0.3
BMI	0.2	1.4	3.8	-0.6	0.0	1.9	1.3	0.6	1.2	1.1	1.9	-1.5	-1.0	0.1
Height	0.2	4.8	17.7	1.3	0.8	2.7	-4.2	-0.3	-0.6	-2.6	-0.2	2.1	-3.5	-1.0
Waist Hip Ratio (WHR)	0.1	0.6	4.3	-0.4	0.2	0.3	-0.2	-0.1	2.1	0.0	0.1	1.3	0.8	-0.2
Systolic Blood Pressure	0.1	0.4	1.2	-0.4	-0.1	-0.6	1.1	0.5	-0.3	0.7	-1.1	-0.4	-0.0	0.4
Smoking Status	0.3	0.8	3.4	-0.9	-0.6	1.1	1.9	-0.7	0.7	-0.6	0.4	0.4	0.2	-1.0
Allergy or Eczema	0.5	1.3	5.5	-0.6	-0.3	1.5	-2.4	-0.9	1.4	-1.1	-0.3	0.7	0.7	-1.0
Cardiovascular Disease	0.1	0.5	1.4	-0.8	-1.2	0.5	0.5	-0.5	-0.0	-0.5	-1.0	-0.6	0.7	-0.5
Hypothyroidism (self reported)	1.0	2.4	7.6	1.3	1.3	0.4	-1.5	1.4	2.8	0.8	0.3	1.7	2.4	1.1
Respiratory disease	1.1	2.5	5.5	-1.8	-1.5	0.3	2.3	-1.5	0.4	-1.6	-1.3	2.2	1.0	-1.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.6	-0.6	-0.3	0.5	-0.1	0.4	0.4	-0.0	0.8	-0.3	-0.1
Lung FEV1/FVC ratio	0.2	1.2	2.7	-1.0	-1.0	1.2	-0.6	-0.7	1.4	-0.5	-0.6	1.6	1.5	-1.1
Lung FVC	0.4	1.9	4.6	1.6	1.6	-2.1	1.1	1.7	0.4	1.5	1.0	0.1	0.0	1.8
Neuroticism	0.2	0.6	3.1	-0.2	-0.3	-0.3	-0.6	-0.4	0.7	-0.5	-0.3	-1.2	1.8	-0.2
Chronotype (morning person)	1.0	2.3	7.1	-1.7	-1.8	2.7	-0.2	-1.8	-1.2	-1.6	-0.6	0.6	-0.8	-1.9
Hair Pigment	0.5	14.8	30.7	-4.8	-5.5	-0.2	4.6	-4.4	-1.9	-2.7	-3.3	-4.4	3.4	-3.8
Tanning	0.4	5.2	10.9	2.8	3.1	-3.3	-1.2	3.0	1.9	2.4	1.0	0.1	-0.6	2.8
Hand grip strength (left)	0.6	1.6	5.3	1.4	2.0	0.7	-0.6	1.5	0.4	1.0	0.9	0.5	-2.3	1.0
Number of treatments/medications taken	0.8	1.5	5.1	-0.9	-1.0	0.8	-0.6	-1.1	-0.2	-1.6	-2.2	1.2	1.1	-1.3
Average weekly spirits intake	0.9	1.1	4.4	1.0	1.0	0.5	-1.6	0.6	0.3	0.1	1.4	2.1	-0.3	0.6
Sensitivity / hurt feelings	0.5	0.8	3.2	-0.0	-0.1	-0.3	-1.3	0.3	0.3	0.2	-1.6	-1.1	1.8	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	-0.9	-0.6	-1.2	-0.5	-0.6	1.0	-0.1	-0.3	-0.2	0.2	-0.6
Hearing difficulty/problems: Yes	0.6	1.0	4.6	-0.1	0.0	-1.0	0.0	-0.7	1.2	-0.6	2.1	0.4	1.6	-0.4
Relative age of first facial hair	1.1	2.4	4.7	-1.4	-1.9	0.6	1.3	-2.0	-2.2	-2.0	-1.1	0.9	-0.2	-1.9
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.5	1.9	1.8	-1.5	-0.9	1.7	1.1	0.9	1.0	-0.8	-0.6	1.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	5.7	-0.2	-0.6	-0.6	0.3	-0.2	0.3	-0.0	0.3	0.2	2.4	0.0
Ever had hysterectomy (womb removed)	0.2	0.3	1.1	-0.0	-0.3	-0.2	0.1	-0.6	-0.9	-1.0	-0.2	-0.2	0.5	-0.4
Systolic blood pressure, automated reading	0.1	0.2	0.9	-0.3	-0.0	-0.0	-0.3	-0.1	-0.9	-0.5	-0.3	0.3	-1.0	-0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.7	0.5	0.7	-0.1	0.8	1.3	1.6	1.6	1.0	-0.6	0.9	1.3
Angina	0.7	0.9	3.5	-0.1	-0.8	-0.3	0.6	-0.8	-1.1	-1.9	-0.7	1.2	0.9	-1.0
Medication for hormone replacement therapy	0.6	0.7	2.7	-0.8	-0.9	0.1	-0.4	-0.6	1.5	-0.1	0.3	0.3	1.7	-0.6
Vitamin and mineral supplements	0.4	0.6	2.9	0.4	0.9	-1.3	0.2	0.2	0.0	0.4	0.5	0.1	-1.7	0.2
Supplements: Zinc	1.3	1.5	3.4	-1.7	-1.9	1.5	0.4	-1.5	0.5	-1.2	-0.1	0.4	0.7	-1.6
Medication: Co-codamol	0.7	0.8	1.8	-0.9	-0.8	0.4	1.3	-1.0	0.7	-1.4	0.6	0.3	0.5	-1.2
Medication: Metformin	0.3	0.5	1.8	-1.3	-0.9	0.8	0.4	-0.3	0.9	0.3	-0.4	0.6	-0.2	-0.6
Diabetes (father)	0.4	0.4	2.1	0.0	0.1	-0.4	-1.1	-0.4	0.6	-0.5	1.4	0.7	-0.5	-0.4
Diabetes (mother)	0.9	1.2	2.6	1.2	1.2	-1.6	-0.7	1.1	0.7	1.3	0.5	1.0	0.2	1.5
Severe depression (siblings)	1.0	1.1	2.2	-1.2	-1.1	0.9	-1.0	-1.3	0.3	-1.2	-0.1	1.0	-1.4	-1.5
Pack years adult smoking proportion	0.2	0.3	1.3	-1.1	-0.6	0.3	0.2	-0.1	1.1	0.6	0.3	-0.2	-0.4	-0.3
Impedance of leg (right)	0.7	3.5	10.3	-1.8	-1.7	-1.7	-1.1	-2.3	-1.6	-1.9	-3.2	1.0	1.2	-1.9
Leg fat-free mass (left)	0.5	2.5	10.3	1.0	1.1	1.8	0.8	1.4	1.1	0.8	3.2	-1.4	-2.2	0.8
Trunk fat percentage	0.1	0.5	1.3	-1.1	-0.8	0.9	-0.9	-0.6	0.4	0.1	0.7	-0.6	0.3	-0.6
Hand grip strength (right)	0.4	1.2	5.5	0.2	0.6	1.9	-0.2	0.0	-1.0	-0.3	-0.4	1.3	-2.3	-0.5
Townsend deprivation index at recruitment	0.7	0.9	5.6	0.3	-0.1	-0.6	2.4	0.2	0.3	0.0	0.2	-2.0	0.5	0.2
Current tobacco smoking	0.5	0.8	2.8	-0.5	-0.4	1.6	1.7	-0.6	0.2	-1.1	-0.8	0.1	-0.1	-0.9
Average weekly fortified wine intake	1.6	1.9	4.6	-1.4	-1.4	1.6	-1.1	-1.6	-0.2	-1.6	-0.6	2.2	0.8	-1.6
Maternal smoking around birth	0.2	0.2	0.6	-0.4	-0.5	0.5	0.5	-0.6	-0.5	-0.1	-0.0	0.8	0.5	-0.4
Fed-up feelings	0.4	0.7	1.7	-1.0	-1.0	1.1	-0.3	-0.9	0.1	-0.6	1.3	0.0	0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	-1.1	-0.8	-1.2	0.0	-0.4	0.3	0.2	0.1	-0.9	0.7	-0.3
Relative age voice broke	0.8	1.3	2.2	-1.2	-1.3	1.2	0.1	-0.9	-1.4	-1.1	-1.5	1.2	-0.7	-1.1
Taking other prescription medications	1.1	1.6	6.7	-1.3	-1.1	1.4	-0.5	-0.8	1.0	-1.0	-0.8	1.3	2.6	-1.1
Age when periods started (menarche)	0.3	0.6	1.2	-0.7	-0.9	0.2	1.1	-0.6	0.5	-0.9	-0.1	0.9	1.1	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.2	-0.3	-0.4	0.2	-0.7	-0.4	1.1	-0.1	-0.2	-0.9	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.1	0.8	0.6	1.4	-0.3	0.7	-0.4	0.5	-1.3	-0.2	-0.3	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.0	-0.7	-0.5	-0.2	-0.3	0.5	1.4	1.2	1.1	-0.9	-0.0	0.2
Qualifications: CSEs or equivalent	1.2	1.6	4.5	1.5	1.6	-2.1	-0.1	1.0	1.1	0.7	1.8	-1.2	0.3	1.1
Serious illness, injury or assault to yourself	1.7	2.1	4.3	-1.7	-2.1	1.6	1.4	-1.5	-1.2	-1.1	1.7	0.4	-0.9	-1.6
High blood pressure	0.2	0.7	1.8	-0.4	-0.8	0.0	0.4	-0.6	0.0	-1.3	-1.1	-1.4	0.9	-0.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.6	-0.3	-0.2	1.2	-1.6	-0.7	0.3	-1.4	-1.1	-0.4	-0.1	-0.9
Multivitamins +/- minerals	0.2	0.3	1.2	0.1	-0.4	1.1	-1.0	-0.2	-0.2	-0.2	0.3	0.2	0.8	-0.0
Stomach or abdominal pain in last month	0.4	0.5	2.3	-0.1	-0.2	-0.3	1.1	-0.2	0.1	-0.4	1.5	-1.0	-0.4	-0.2
Supplements: Glucosamine	0.7	0.9	2.4	-0.1	-0.5	1.1	-0.5	-0.9	-1.5	-1.6	-0.5	1.1	-0.4	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	0.7	0.8	-1.4	-1.5	0.6	-0.5	0.7	-0.0	0.5	-0.7	0.8
Medication: Atenolol	0.9	1.2	3.2	1.3	1.1	-1.3	-1.5	0.2	-1.3	-0.9	-1.8	0.1	-0.4	0.3
Medication: Levothyroxine sodium	1.0	1.8	7.3	0.2	0.7	0.3	-2.7	0.3	2.3	0.2	-1.1	1.2	1.8	0.1
Sitting height	0.3	1.9	5.8	0.8	-0.1	2.2	0.8	-0.5	-1.7	-2.4	-0.0	1.3	-1.9	-1.0
Chronic bronchitis/emphysema (father)	1.0	1.2	9.7	0.5	0.1	1.0	0.5	-0.1	0.0	-0.8	3.1	1.0	0.5	-0.1
High blood pressure (mother)	0.9	1.3	2.7	-1.2	-1.6	0.6	0.9	-1.5	-0.7	-1.5	1.2	0.5	0.7	-1.3
Body mass index (BMI)	0.4	1.9	7.8	0.0	0.7	0.8	0.0	1.1	1.4	1.7	2.8	-2.1	-0.8	0.9
Impedance of leg (left)	1.0	5.1	12.7	-1.7	-1.9	-1.3	-1.7	-2.9	-2.5	-2.7	-3.6	1.8	1.2	-2.3
Leg predicted mass (left)	0.4	2.3	10.0	0.8	0.9	1.9	0.9	1.2	1.0	0.7	3.2	-1.4	-2.1	0.6
Trunk fat mass	0.1	0.6	2.2	-0.7	-0.3	1.3	-0.8	-0.2	0.5	0.2	1.5	-0.8	-0.6	-0.4
Waist circumference	0.3	1.1	6.2	0.0	0.5	1.3	-0.3	0.6	1.3	0.5	2.5	-0.6	-1.0	0.2
Number of incorrect matches in round	1.1	1.8	8.0	-0.7	-0.9	-0.7	0.9	-0.7	-1.7	-0.9	-2.2	-2.8	-0.5	-0.7
Past tobacco smoking	0.5	0.9	3.0	0.7	0.7	-0.9	-1.7	1.0	1.1	1.3	-0.4	-0.3	-0.1	1.2
Alcohol usually taken with meals	0.8	1.3	4.0	0.2	-0.3	2.0	-1.0	-0.9	-0.8	-1.5	0.3	1.6	1.3	-0.7
Nervous feelings	0.3	0.5	1.9	0.0	0.2	-0.6	-0.6	-0.2	0.2	-0.6	-1.2	-1.4	-1.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	1.9	3.6	-1.7	-1.9	-1.3	1.3	-1.6	-0.3	-1.6	-1.4	-0.1	1.2	-1.6
Hearing difficulty/problems with background noise	0.8	1.2	4.3	-0.5	-0.8	-1.1	0.8	-1.6	-0.2	-2.1	0.4	0.4	1.3	-1.4
Hair/balding pattern: Pattern 2	1.1	1.5	3.4	-1.8	-1.9	0.6	1.7	-1.2	-0.6	-0.5	-1.0	0.5	1.1	-1.2
Had menopause	1.0	1.2	8.0	0.1	-0.1	0.6	-1.0	0.3	1.7	0.1	0.9	0.3	2.8	0.3
Had other major operations	0.6	0.7	6.1	-0.9	-0.6	-0.4	-2.5	-0.5	0.4	0.1	0.2	-0.4	0.2	-0.4
Forced vital capacity (FVC)	0.1	0.3	1.1	0.9	0.6	-0.7	-0.1	0.2	-0.7	-0.3	-0.0	1.0	-0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.2	0.9	0.8	1.5	-0.7	0.7	-0.6	0.7	-1.1	0.2	-0.2	0.9
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	8.3	-2.5	-2.9	1.9	1.1	-2.5	-1.7	-2.6	-1.4	1.2	0.9	-2.8
Qualifications: None of the above	0.5	1.1	5.3	-0.8	-0.8	-1.4	1.3	0.1	0.3	1.0	-0.1	-2.3	0.6	0.3
Financial difficulties in last 2 years	0.2	0.3	1.9	-0.4	-0.2	-0.6	0.7	0.1	0.0	0.6	-0.3	-1.4	-0.3	0.0
Mouth/teeth dental problems	0.3	0.5	1.1	-0.7	-0.7	0.3	-0.6	-0.9	-0.7	-0.2	-1.1	0.1	-0.9	-0.8
Heart attack	1.5	1.9	4.8	-1.0	-1.4	1.0	-0.0	-1.6	-0.6	-1.9	-0.6	2.2	1.6	-1.6
Allergy	0.5	1.2	4.5	0.5	0.6	-1.7	0.1	1.1	0.3	2.1	1.2	-0.5	-0.2	1.4
Pain all over the body in last month	1.3	1.3	2.6	-1.5	-1.6	0.6	0.9	-1.6	0.3	-0.9	1.5	-0.1	1.1	-1.3
Diabetes (self-reported)	0.2	0.3	0.8	-0.9	-0.7	-0.9	-0.1	-0.5	0.4	0.1	0.5	0.5	0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	-0.3	-0.3	1.4	-0.9	-0.4	0.8	-0.7	-1.3	0.8	1.1	-0.6
Medication: Ramipril	0.6	0.8	2.3	0.5	0.6	-0.7	-0.8	0.8	1.5	0.5	-1.5	-0.2	1.3	0.7
Medication: Simvastatin	0.7	1.1	2.3	-1.0	-1.1	0.4	-1.4	-1.5	-0.1	-1.4	-0.6	0.8	0.6	-1.3
Fluid intelligence score	0.2	0.4	2.8	-0.1	0.3	-0.2	-0.9	-0.1	0.2	0.3	-0.6	-1.7	-0.6	0.2
Illnesses of siblings	0.2	0.3	1.1	-0.2	-0.3	-0.5	0.3	-0.5	-1.1	-0.4	-0.5	0.7	-0.3	-0.4
Neuroticism score	0.2	0.5	1.4	-0.5	-0.4	-0.6	-0.7	-0.7	0.0	-1.1	-0.4	-1.2	0.5	-0.6
Weight	0.4	1.8	7.6	0.6	0.9	1.6	-0.8	0.9	0.6	0.6	2.8	-1.2	-2.1	0.5
Impedance of arm (right)	0.7	3.5	11.9	-1.4	-1.9	-0.4	-1.4	-2.1	-1.7	-2.0	-3.5	1.7	1.4	-1.6
Arm fat percentage (right)	0.3	1.0	2.6	-0.8	-0.2	0.8	-0.4	0.5	1.5	1.6	1.4	-1.6	0.4	0.5
Trunk fat-free mass	0.4	2.0	7.0	1.2	1.2	1.8	0.1	1.2	0.6	0.4	2.5	-0.8	-2.6	0.6
Hip circumference	0.4	1.8	7.6	0.9	1.0	1.3	-0.7	1.3	0.3	0.9	2.8	-1.3	-1.9	0.9
Time employed in main current job	2.3	2.6	5.4	1.8	2.3	-1.6	-2.0	2.0	0.9	1.7	0.9	0.8	0.4	2.0
Alcohol intake versus 10 years previously	0.9	1.3	2.9	-1.3	-1.0	1.2	1.6	-0.8	1.7	-0.9	-0.8	0.4	1.1	-1.2
Father’s age at death	0.6	0.8	2.1	1.1	1.1	1.3	0.5	0.9	-0.9	0.5	0.5	0.4	-1.4	0.8
Worrier / anxious feelings	0.4	0.7	1.7	-1.2	-1.1	0.4	-0.5	-0.9	0.3	-0.7	-0.6	-1.3	0.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.2	-1.8	-1.6	-0.3	1.7	-1.1	0.5	-0.8	-1.0	-0.3	-0.1	-1.4
Falls in the last year	2.7	3.6	7.6	-2.3	-2.7	-0.1	1.8	-2.6	-0.9	-2.8	0.0	0.7	0.5	-2.7
Hair/balding pattern: Pattern 3	0.7	1.1	2.2	1.2	1.5	-0.0	-1.5	1.4	0.3	1.1	0.9	0.1	-1.0	1.1
Number of live births	1.4	2.0	8.0	1.0	1.0	-1.7	0.6	1.5	0.9	1.3	2.8	-1.0	-1.1	1.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	1.4	0.6	0.4	-0.5	-0.2	0.1	-0.2	-0.2	0.3	1.2	-0.4	0.0
Pulse rate	0.3	0.6	2.0	-1.2	-1.0	1.4	0.1	-0.5	0.1	-0.2	-0.0	0.5	-0.7	-0.7
Happiness	2.1	2.5	8.2	1.8	1.9	-2.9	-2.0	1.5	-0.4	1.1	1.3	-0.3	-0.4	1.7
Noisy workplace	0.5	0.6	2.6	0.6	0.4	-1.6	0.2	0.9	0.5	0.7	0.6	0.7	0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.3	-0.4	-0.3	2.1	-1.5	-0.9	-1.6	-1.4	-0.4	1.5	-0.9	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.3	1.5	1.5	-1.5	-1.4	0.5	-0.8	-0.3	0.0	0.2	-1.4	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	1.0	0.3	0.3	0.1	0.5	0.3	1.0	-0.2	0.6	0.1	-0.6	0.0
Asthma	1.4	2.7	5.8	-1.8	-1.6	1.3	1.5	-1.6	-0.3	-1.9	-1.8	2.4	0.1	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	-1.5	-1.0	0.5	1.4	-1.1	0.2	-0.4	0.5	-0.5	-0.4	-1.3
Medication: Cholesterol lowering	1.9	2.9	7.7	-2.1	-2.2	1.7	0.8	-1.8	1.1	-1.5	-0.8	1.0	2.8	-1.8
Depression (self-reported)	0.9	1.1	2.1	-1.4	-1.4	0.0	0.3	-1.4	0.2	-1.4	-1.4	0.3	-0.0	-1.4
Medication: Lansoprazole	3.1	3.6	6.7	-2.3	-2.6	1.6	2.6	-2.3	-0.7	-2.1	-1.1	0.2	-0.1	-2.6
Prospective memory result	0.7	0.9	1.9	0.6	0.3	-0.7	0.8	1.1	0.6	1.4	1.3	-0.8	0.7	1.3
Lung cancer (father)	0.7	0.8	2.0	-0.8	-1.1	0.4	0.2	-1.4	-0.8	-1.3	1.3	-0.2	0.2	-1.1
Illnesses of mother	2.3	2.8	6.0	2.0	2.5	-0.8	-0.5	2.1	0.3	2.2	-0.9	-1.8	-1.5	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.6	1.9	1.6	-1.5	-0.4	1.3	0.8	0.4	1.7	0.4	-0.8	1.1
Pulse wave Arterial Stiffness index	0.2	0.2	1.5	0.2	0.0	0.1	-0.4	0.2	-1.2	0.5	0.6	-0.1	-0.4	0.3
Impedance of arm (left)	0.8	3.8	9.2	-1.5	-2.0	-0.1	-1.0	-2.4	-1.8	-2.4	-3.0	2.2	1.4	-2.0
Arm fat mass (right)	0.2	1.0	3.1	-0.6	-0.2	1.5	-0.1	0.4	1.1	0.9	1.8	-1.6	-0.4	0.2
Trunk predicted mass	0.4	2.0	6.8	1.2	1.2	1.9	0.1	1.2	0.6	0.4	2.5	-0.8	-2.6	0.6
Standing height	0.2	2.4	8.6	1.3	0.6	1.6	-1.6	-0.3	-1.6	-2.2	0.3	1.5	-2.9	-0.7
Length of working week for main job	0.2	0.2	0.5	-0.2	-0.5	-0.4	0.7	-0.6	-0.5	-0.7	0.3	-0.6	0.0	-0.4
Exposure to tobacco smoke at home	0.3	0.4	2.8	-0.2	-0.4	0.3	-0.1	0.2	0.9	0.1	1.7	0.5	-0.2	-0.0
Breastfed as a baby	0.6	0.7	2.2	0.4	0.7	0.5	-1.0	0.8	1.5	1.2	0.1	-0.7	-0.4	0.9
Tense / ‘highly strung’	0.3	0.5	1.8	0.0	-0.0	-0.9	-0.9	-0.8	0.0	-1.3	-0.4	-0.8	0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	6.0	-2.4	-2.4	0.6	1.4	-1.9	1.8	-1.6	-0.1	-0.1	1.5	-2.1
Hair/balding pattern: Pattern 4	0.4	1.0	1.8	0.7	1.2	-0.5	-1.2	0.8	1.4	0.9	0.9	1.2	0.6	0.8
Birth weight of first child	0.4	0.8	4.2	1.0	0.6	0.0	-0.8	0.8	0.5	-0.4	2.0	1.2	0.1	0.4
Peak expiratory flow (PEF)	0.4	1.0	2.0	1.3	1.4	-0.9	-1.3	1.1	-0.1	0.8	0.1	1.2	-0.6	0.9
Pulse wave reflection index	0.3	0.3	1.2	0.2	0.5	-0.9	-0.1	0.3	0.0	0.7	1.1	0.6	-0.3	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.4	0.2	0.0	-1.5	-0.6	-0.0	-0.6	-0.1	-0.3	-1.0	0.6	0.1
Loud music exposure frequency	0.9	1.0	3.9	-0.6	-0.8	0.7	2.0	-0.8	0.0	-0.7	1.8	-0.2	-0.6	-0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.9	1.1	1.0	0.5	-1.3	-0.2	-1.1	-1.4	0.9	-0.0	-0.9	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	-0.2	-0.5	-0.1	-0.5	-0.2	0.2	-1.1	0.3	-0.6	1.0	-0.4
Blood clot in the leg (DVT)	0.4	0.5	1.1	-0.7	-1.1	0.0	0.1	-0.7	-0.5	-1.0	0.2	-0.6	0.9	-0.7
Medication: Paracetamol	0.7	1.1	2.4	1.2	1.2	-1.5	0.0	1.1	-0.2	0.8	0.4	-1.5	-1.2	1.1
Headache pain in last month	0.4	0.7	3.0	-0.5	-0.4	-0.1	0.9	0.3	1.7	0.2	0.6	-0.4	1.6	0.1
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	7.8	2.7	2.8	-2.5	-1.6	2.3	-0.4	1.8	1.2	-0.9	-1.9	2.3
Glaucoma (self-reported)	0.3	0.4	1.2	0.5	0.3	-0.7	-0.8	0.2	-0.8	-0.2	-1.1	-0.7	-0.1	0.3
Gout (self-reported)	0.6	0.9	3.0	-1.1	-0.9	1.7	1.2	-0.8	0.4	-0.5	-1.1	-0.2	0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	5.7	1.3	1.3	0.6	-2.1	1.1	2.4	0.4	0.2	2.0	2.0	0.8
Medication: Amlodipine	0.9	1.2	4.3	-1.0	-1.1	0.6	2.1	-0.7	-0.4	-1.4	-1.5	0.4	0.4	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.1	0.5	0.8	0.0	1.5	0.4	-0.6	-0.4	-0.2	1.0	-0.3	0.1
Birth weight	0.4	0.8	4.2	-0.7	-0.8	0.1	0.9	-0.0	0.4	0.1	-2.0	0.5	1.4	-0.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.3	0.0	-0.6	0.7	-1.3	-0.4	-0.0	-0.9	1.8	0.5	0.8	-0.5
High blood pressure (siblings)	0.3	0.4	1.8	0.6	0.4	1.0	0.2	0.3	0.2	-0.5	1.3	-0.3	-0.8	0.1
Forced vital capacity (FVC), Best measure	0.3	1.1	2.7	1.6	1.4	-1.6	-0.1	0.8	0.0	0.0	1.6	0.2	-1.2	0.8
Body fat percentage	0.1	0.5	1.3	-1.0	-0.5	0.5	-0.7	-0.3	0.7	0.5	1.1	-0.9	0.4	-0.3
Leg fat percentage (right)	0.3	1.0	3.4	-1.1	-0.3	0.1	-0.5	0.1	1.4	1.2	1.9	-1.5	0.4	-0.0
Arm fat-free mass (right)	0.4	1.9	8.4	0.8	0.8	2.0	0.5	0.6	0.4	-0.1	2.9	-0.9	-2.5	0.0
Exposure to tobacco smoke outside home	0.3	0.5	1.9	-0.9	-0.8	0.3	1.4	-0.4	0.7	-0.1	-0.4	-0.3	-0.5	-0.6
Comparative body size at age 10	0.1	0.3	1.1	-0.5	-0.3	0.2	-0.8	-0.0	1.0	0.5	0.2	-0.6	0.4	-0.1
Number of full brothers	1.3	1.6	3.9	0.5	0.4	-2.0	1.9	1.2	1.3	1.0	-0.4	-1.4	1.3	1.1
Worry too long after embarrassment	0.7	1.2	2.5	-0.9	-1.2	-1.0	1.2	-1.2	-0.2	-1.6	-0.5	-0.7	1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.1	-0.9	-1.0	0.9	0.4	-0.6	1.8	-0.5	0.9	-0.3	0.8	-0.7
Wheeze or whistling in the chest in last year	2.1	3.7	8.9	-2.9	-2.3	1.4	0.9	-2.8	-0.3	-2.0	-1.7	0.9	-0.3	-3.0
Number of children fathered	1.0	1.2	4.1	0.5	0.3	-1.9	-0.6	0.1	-1.8	0.0	-2.0	-0.2	0.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	4.0	-0.7	-0.9	0.2	1.0	-0.5	1.7	-0.7	-0.7	1.2	2.0	-0.7
Age at first live birth	0.5	0.8	4.0	0.1	0.2	0.7	-2.0	-0.3	0.1	-0.6	-1.6	1.2	-0.3	-0.4
Pulse wave peak to peak time	0.1	0.2	1.0	0.0	0.1	-0.1	0.2	-0.1	1.0	-0.6	-0.6	0.1	0.1	-0.2
Health satisfaction	0.2	0.3	1.0	-0.9	-1.0	-0.2	-0.4	0.2	-0.1	0.4	0.0	-0.7	0.7	0.1
Shortness of breath walking on level ground	0.6	0.7	2.6	-1.0	-0.8	0.2	0.1	-0.8	0.9	-0.8	0.3	0.1	1.6	-0.9
Qualifications: College or University degree	0.9	3.0	6.7	-0.6	-0.7	1.9	-2.4	-1.7	-1.9	-2.1	-1.5	2.6	0.2	-1.5
Eye problems/disorders: None of the above	0.3	0.4	1.2	0.7	0.2	0.7	-0.4	-0.3	-1.1	-1.0	0.3	0.7	-0.2	-0.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	5.2	-1.1	-1.1	0.8	-0.2	-2.0	-2.0	-2.3	-2.2	0.1	-1.4	-2.0
Emphysema/chronic bronchitis	2.0	2.3	6.3	-1.5	-1.5	1.6	1.7	-1.3	1.1	-1.3	0.8	2.5	0.7	-1.6
Medication for pain relief, constipation, heartburn	0.2	0.3	1.5	0.1	-0.0	-0.4	-0.4	-0.4	-0.1	-0.3	1.2	1.2	-0.3	-0.3
Neck or shoulder pain in last month	0.2	0.3	1.4	-0.0	-0.4	0.0	1.2	-0.3	0.2	-0.8	0.9	0.1	-0.6	-0.5
Medication: Blood pressure	0.7	1.3	2.9	-1.1	-1.1	1.5	1.7	-1.0	0.5	-1.1	-0.9	0.8	1.2	-1.1
Angina (self-reported)	0.7	0.9	3.1	-0.2	-0.9	-0.2	0.7	-0.8	-1.1	-1.8	-0.9	1.0	0.8	-1.0
Migraine (self-reported)	1.5	1.8	5.7	-2.4	-2.1	1.4	0.9	-1.8	-0.4	-0.8	-0.3	-0.3	0.4	-1.7
Medication: Ibuprofen	0.2	0.3	1.1	-0.6	-0.1	0.6	0.0	-0.5	-0.1	-0.4	0.4	0.0	-1.1	-0.7
Medication: Allopurinol	0.3	0.4	1.2	-0.3	0.2	0.7	0.4	0.2	1.1	0.8	-0.8	-0.7	0.3	0.3
Medication: Omeprazole	1.0	1.2	2.6	-1.0	-1.3	-0.2	1.1	-1.2	-1.2	-1.6	-0.5	-1.0	-0.9	-1.3
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.3	0.5	-0.7	-0.1	0.2	0.2	0.4	0.1	0.2	-0.3	0.3
Mean time to correctly identify matches	0.1	0.2	0.8	-0.9	-0.5	0.5	0.3	-0.4	0.4	0.1	0.7	0.3	0.2	-0.5
Heart disease (mother)	1.4	1.7	5.0	-1.0	-1.1	0.4	-1.0	-1.6	-1.0	-2.2	-0.4	1.7	-0.4	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	0.5	0.1	-0.7	-0.9	0.0	-0.4	-0.2	-0.5	-0.4	0.2	0.1
Whole body fat mass	0.2	0.7	3.5	-0.8	-0.3	1.4	-0.4	-0.1	0.8	0.5	1.9	-1.0	-0.4	-0.3
Leg fat mass (right)	0.3	1.0	5.2	-0.7	-0.1	0.8	-0.1	0.3	1.2	0.9	2.3	-1.5	-0.5	-0.0
Arm predicted mass (right)	0.4	1.9	8.4	1.0	1.0	1.7	0.4	0.9	0.6	0.1	2.9	-0.8	-2.3	0.3
Pulse rate, automated reading	0.2	0.5	2.3	-0.2	0.1	0.5	0.6	1.0	1.5	0.9	-0.3	0.6	0.1	0.5
Alcohol intake frequency.	0.5	1.1	3.1	-1.0	-0.6	1.1	1.1	0.3	1.4	1.7	0.2	-1.8	-0.1	0.4
Comparative height size at age 10	0.5	2.8	6.1	2.4	2.5	-0.5	-2.4	1.7	-0.1	0.7	1.1	0.1	-2.5	1.4
Number of full sisters	2.1	2.5	15.5	-0.5	-0.9	-1.6	1.3	0.1	1.3	0.0	-1.9	-1.1	3.9	0.2
Suffer from ‘nerves’	0.3	0.4	1.6	0.4	0.6	-1.1	-1.3	0.2	0.1	0.1	-0.4	-0.9	-0.6	0.2
Overall health rating	0.4	0.9	2.2	-1.3	-1.2	0.1	-0.8	-1.4	0.7	-1.2	-0.4	0.0	0.3	-1.5
Chest pain or discomfort	1.1	1.6	3.8	-1.3	-1.3	1.4	-0.4	-1.4	-0.2	-2.0	0.3	1.7	-0.7	-1.8
Had major operations	1.3	1.6	5.0	0.1	-0.7	0.7	0.6	-1.1	-2.2	-2.1	-0.9	1.2	-1.3	-1.1
Age at last live birth	0.5	0.8	3.1	0.5	1.0	-0.7	-1.8	0.1	0.4	0.1	0.5	-0.2	-1.7	0.1
Family relationship satisfaction	0.3	0.4	1.2	-0.4	-0.7	-0.5	-0.5	-0.7	-0.7	-0.6	-0.8	1.1	-0.1	-0.6
Leg pain on walking	0.7	0.8	2.7	-0.6	-0.7	0.5	-1.6	-1.2	-0.4	-1.3	-0.0	0.8	-0.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.7	0.3	-0.3	0.4	0.7	-0.5	0.6	1.1	0.3	-0.5	0.7
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.7	-0.5	-0.7	-0.2	-0.0	-1.5	-0.8	-1.7	1.6	1.9	-1.1	-1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.9	0.2	0.3	0.2	-1.0	0.6	1.1	0.8	-1.0	0.1	2.0	0.8
Medication: Aspirin	0.5	0.7	2.7	-0.6	-0.6	1.6	-0.5	-0.3	0.8	-0.6	-0.3	1.1	1.2	-0.6
Supplements: Vitamin C	1.3	1.5	3.8	-1.5	-2.0	1.2	0.4	-1.4	0.3	-1.3	-0.1	0.3	1.8	-1.3
Knee pain experienced in last month	1.0	1.6	4.9	1.8	1.6	-2.2	-0.2	1.5	-0.2	0.4	0.8	-0.7	-0.9	1.4
Hypertension (Self-reported)	0.2	0.5	2.0	-0.2	-0.6	-0.2	0.6	-0.4	0.2	-1.0	-0.6	-1.2	1.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	0.4	-0.2	-0.3	1.0	-0.3	-0.6	-1.7	-1.0	-1.3	0.5	-0.6
Illnesses of father: Heart disease	0.4	0.6	3.6	0.2	0.1	-1.2	-1.9	-0.4	-0.5	-1.0	0.0	-0.0	-0.1	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	2.8	0.1	0.3	-1.0	-0.8	0.1	0.2	0.5	-1.2	-1.7	0.1	0.3
Smoking status: Previous	0.5	0.7	2.4	-0.6	-0.9	-0.3	0.5	-1.0	-1.6	-1.1	0.4	0.3	0.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	5.7	0.7	0.6	0.5	-0.4	0.2	0.1	-0.9	0.9	0.3	-2.4	-0.2
Whole body fat-free mass	0.4	2.1	7.4	1.1	1.1	2.1	0.4	1.1	0.6	0.4	2.7	-1.0	-2.5	0.6
Leg fat-free mass (right)	0.4	2.3	9.4	1.2	1.0	2.0	0.8	1.2	0.6	0.3	3.1	-1.0	-2.3	0.6
Arm fat percentage (left)	0.2	0.9	2.2	-0.8	-0.2	1.0	-0.3	0.3	1.2	1.3	1.5	-1.4	0.2	0.2
Average weekly red wine intake	2.6	3.8	8.9	-1.8	-2.0	3.0	-0.5	-2.1	-1.3	-2.5	-0.5	2.7	0.4	-2.3
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.0	2.1	2.2	-0.9	-1.0	1.3	-0.4	0.3	0.6	-0.8	-1.5	1.4
Mood swings	0.2	0.4	1.1	-0.6	-0.7	0.5	0.8	-0.4	-0.1	-0.3	0.5	1.0	1.0	-0.5
Loneliness, isolation	0.1	0.2	1.1	-0.3	-0.1	0.1	-1.0	-0.2	0.2	-0.2	0.4	0.1	-0.4	-0.3
Long-standing illness, disability or infirmity	0.3	0.5	1.7	0.5	0.3	-0.7	0.5	0.7	1.1	0.2	0.3	0.5	1.3	0.5
Ever had bowel cancer screening	1.2	1.4	5.5	0.2	0.1	-0.7	0.1	-0.5	-0.9	-0.5	2.4	-2.1	-1.8	-0.2
Diabetes diagnosed by doctor	0.1	0.2	1.1	-0.5	-0.3	-1.1	-0.1	0.1	0.7	0.6	0.1	-0.2	0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.4	-1.1	-1.0	0.2	1.8	-0.8	0.1	-0.4	-0.3	0.4	0.5	-1.0
Friendships satisfaction	0.4	0.5	2.4	0.0	0.4	-1.6	-1.3	0.2	-0.0	0.7	0.1	-0.7	0.3	0.4
Qualifications: nursing, teaching	1.5	2.4	5.1	-1.4	-1.3	1.1	-0.8	-2.0	-0.9	-2.3	-1.4	2.1	0.2	-2.0
Commuting to job workplace: Walk	3.3	3.6	8.5	2.0	2.5	-1.2	-0.8	2.8	1.5	2.9	0.5	-0.3	0.5	2.8
Eye problems/disorders: Cataract	0.4	0.4	1.2	-0.4	-0.1	0.9	1.0	0.1	1.1	0.7	-0.8	0.6	0.6	0.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.2	1.0	1.0	-0.7	0.7	2.0	0.7	2.0	0.7	-0.2	1.1	2.0
Medication for cholesterol	0.7	1.0	3.5	0.6	0.9	0.8	1.5	0.7	-0.9	0.3	1.3	0.1	-1.9	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.6	3.1	-0.0	0.1	-0.8	0.9	0.6	1.8	0.8	-0.3	0.2	1.1	0.3
Back pain experienced in last month	0.6	0.9	4.1	-1.0	-0.8	0.9	0.3	-0.4	0.9	-0.6	2.0	0.9	-0.2	-0.7
Mineral and other dietary supplements	0.8	1.1	3.1	1.0	1.2	-1.8	0.0	1.0	0.1	1.1	0.9	-1.1	-1.3	1.0
Breast cancer (self-reported)	1.7	2.0	5.8	-2.4	-2.0	1.1	0.8	-1.9	-0.1	-1.5	0.0	0.2	-0.1	-2.1
Asthma (self-reported)	1.9	3.7	6.8	-2.1	-2.0	1.4	1.7	-2.1	-0.6	-2.3	-2.0	2.6	0.2	-2.6
Osteoporosis (self-reported)	0.9	1.1	3.4	-0.3	-0.4	-0.2	-0.5	-0.8	-1.6	-0.9	-1.8	-0.9	-1.7	-0.9
Osteoarthritis (self-reported)	0.8	1.1	3.2	0.2	0.3	-0.3	-1.8	-0.6	-0.9	-0.8	1.2	-1.3	-1.8	-0.3
Medication: Aspirin	0.3	0.4	1.9	-0.1	-0.2	1.4	-0.7	-0.2	0.4	-0.7	0.1	0.9	0.8	-0.4
Medication: Gliclazide	0.7	0.8	3.9	0.2	0.5	-1.1	-1.6	0.5	-0.3	0.7	-2.0	-0.0	0.1	0.4
Illnesses of father: None of the above (group 1)	0.9	1.1	2.9	0.2	0.5	-0.8	0.7	0.9	1.4	1.7	-0.5	-1.2	1.5	1.0
Smoking status: Current	0.5	0.7	3.6	-0.4	-0.1	1.9	1.4	-0.4	0.6	-0.8	-0.7	0.4	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.6	0.6	0.4	-1.4	0.4	1.2	1.2	1.6	1.6	-0.4	0.1	1.3
Whole body water mass	0.4	2.1	7.6	1.1	1.0	2.1	0.3	1.1	0.6	0.3	2.8	-0.9	-2.5	0.5
Leg predicted mass (right)	0.4	2.2	9.2	1.2	1.0	2.0	0.7	1.1	0.5	0.2	3.0	-1.1	-2.3	0.6
Arm fat mass (left)	0.3	1.2	4.7	-0.5	-0.1	1.6	-0.0	0.5	1.1	1.1	2.2	-1.6	-0.5	0.3
Number of self-reported non-cancer illnesses	1.4	2.5	7.3	-1.3	-1.4	0.9	-0.1	-1.9	0.1	-2.7	-1.0	2.4	0.9	-2.1
Average weekly champagne plus white wine intake	0.7	1.0	2.8	0.1	-0.1	1.7	-1.5	-0.9	-1.3	-1.3	-0.7	-0.3	-1.0	-0.6
Miserableness	0.1	0.2	0.5	0.2	0.4	-0.7	0.6	0.3	-0.1	-0.1	0.7	-0.6	-0.3	0.2
Guilty feelings	0.5	0.7	4.3	-0.5	-0.5	0.0	0.4	-0.8	-0.9	-0.9	-0.3	-2.1	0.0	-0.6
Wears glasses or contact lenses	1.5	1.8	11.1	1.3	1.7	-0.2	-3.3	0.7	-0.6	-0.1	-0.6	1.3	-0.7	0.7
Ever taken oral contraceptive pill	0.9	1.0	6.3	1.3	1.1	-0.5	-0.6	0.2	-0.5	-0.6	-0.1	2.5	-0.0	0.2
Hearing aid user	0.4	0.4	1.5	-0.1	-0.0	-0.3	1.1	0.2	0.9	-0.1	0.2	-1.2	0.8	0.2
Mother’s age at death	0.4	0.5	3.5	0.1	0.0	0.7	-0.1	0.3	1.0	0.5	1.9	-0.2	0.4	0.2
Financial situation satisfaction	0.2	0.2	1.1	0.1	0.1	0.2	1.0	0.3	-0.0	0.0	-0.2	-0.6	-0.7	-0.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	4.3	2.1	1.6	-0.6	-1.9	1.1	-0.1	-0.2	0.4	1.3	-0.6	1.2
Commuting to job workplace: Public transport	0.7	0.8	2.5	0.6	0.8	-0.1	0.3	1.3	0.5	1.2	-1.6	-0.9	0.1	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.1	0.4	0.3	-1.4	-1.0	-0.0	-1.0	-0.2	-0.3	-0.7	-0.3	0.2
Medication: Blood pressure	0.5	0.9	5.2	-0.2	-0.6	-1.1	-0.3	-0.2	-0.3	-0.3	-2.3	-1.3	1.1	-0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	-0.7	-0.9	0.1	0.6	-0.8	-0.9	-0.7	1.2	-0.2	-1.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	5.0	0.0	-0.3	-0.2	-0.1	-0.0	0.2	-0.3	-0.2	1.1	2.2	0.1
High cholesterol (Self-reported)	0.5	1.0	2.4	-1.2	-1.3	0.9	-0.7	-1.1	0.5	-0.6	-0.2	0.7	1.5	-1.0
Medication: Bendroflumethiazide	0.6	0.8	2.2	0.8	0.3	-1.2	-0.8	1.0	0.3	0.4	-1.5	-1.2	0.8	1.0
Medication: Paracetamol	0.7	1.2	2.1	1.2	1.2	-1.4	-0.6	1.1	-0.4	1.0	0.3	-1.3	-1.2	1.2
Medication: Lisinopril	0.3	0.4	1.5	0.7	0.8	-0.6	-0.2	0.4	-0.0	0.2	0.6	-1.2	-0.6	0.6
Medication: Atorvastatin	0.2	0.3	1.2	-0.1	0.3	-1.1	-0.2	0.2	0.7	0.5	0.6	-0.9	-0.3	0.2
Illnesses of father: High blood pressure	2.0	2.5	6.8	-1.8	-2.0	2.6	0.4	-1.9	-1.5	-1.5	-0.4	0.6	-0.9	-1.9
Alcohol drinker status: Never	0.5	0.6	2.2	0.8	0.9	0.1	0.2	0.7	-0.2	0.8	0.6	-1.5	-0.6	0.9
Ever smoked	0.7	1.2	6.2	-0.6	-0.5	1.0	2.5	-0.9	-1.0	-1.3	-0.1	-0.2	-0.3	-1.1
Basal metabolic rate	0.4	2.1	8.2	0.9	0.9	2.0	0.3	1.1	0.7	0.4	2.9	-1.2	-2.5	0.5
Leg fat percentage (left)	0.2	0.7	3.0	-1.0	-0.3	0.2	-0.9	-0.1	0.8	0.9	1.7	-1.3	0.3	-0.1
Arm fat-free mass (left)	0.3	1.7	6.0	0.6	0.8	1.8	0.2	0.9	0.6	0.3	2.4	-1.2	-2.4	0.3
Number of operations (self-reported)	0.5	0.7	1.5	-0.5	-0.5	-0.1	-0.3	-1.0	-1.2	-1.2	0.3	1.0	-1.0	-0.9
Average weekly beer plus cider intake	0.3	0.4	2.4	-0.3	-0.2	-0.1	1.5	0.4	0.8	0.9	0.1	0.1	0.7	0.4
Irritability	0.4	0.7	2.1	-0.4	-0.4	0.2	-0.9	-1.2	-0.9	-1.4	0.3	-0.1	0.5	-1.1
Risk taking	0.6	0.9	3.6	-0.6	-0.4	0.9	1.6	-0.7	-1.0	-0.6	-0.1	0.5	-1.9	-0.8
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.8	1.2	1.1	-1.6	0.2	0.7	-0.9	0.2	-0.6	-1.7	-0.8	0.8
Fractured/broken bones in last 5 years	1.3	1.7	3.7	-1.9	-1.8	0.3	1.3	-1.3	-0.8	-0.6	0.6	-0.9	-1.9	-1.6
Age started oral contraceptive pill	0.3	0.3	1.3	0.1	0.1	0.9	-0.3	-0.1	0.4	-0.5	0.9	-0.6	1.1	0.1
Diastolic blood pressure, automated reading	0.1	0.3	1.7	0.0	0.2	0.4	0.1	0.6	-0.7	0.8	0.1	0.4	-1.3	0.4
Ever depressed for a whole week	1.0	1.3	2.5	-1.1	-1.2	-0.2	0.6	-1.5	-0.1	-1.6	0.9	1.2	1.2	-1.5
Unable to work because of sickness or disability	1.2	1.6	6.3	0.0	-0.1	-1.1	1.3	0.4	2.5	0.2	1.0	0.4	2.5	0.3
Commuting to job workplace: Cycle	0.3	0.3	1.6	-0.1	-0.3	0.8	1.3	-0.2	-0.3	-0.5	-0.1	-0.8	-0.2	-0.3
Myopia	0.6	0.8	2.7	0.6	1.2	-1.1	-0.3	0.9	1.6	1.0	-0.5	-0.7	0.5	0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.8	0.4	1.0	-0.2	-0.5	0.8	0.2	1.7	1.3	0.7	-1.4	0.7
Cholesterol lowering medication	0.6	0.9	4.7	1.0	1.0	-1.6	-2.2	0.4	0.2	0.3	-0.0	0.2	0.3	0.7
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-1.0	-1.3	-0.0	1.3	-1.2	-0.8	-1.4	0.2	-1.0	-0.2	-1.2
Pain experienced in last month	0.6	0.9	6.8	-0.6	-0.3	0.8	-0.4	-0.1	0.3	1.0	-2.6	0.1	1.0	-0.0
Supplements: Calcium	0.8	0.9	2.0	-0.6	-0.8	1.0	-1.2	-1.0	0.0	-1.2	-1.4	0.1	1.0	-0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	-0.7	-0.5	0.2	-0.0	-0.7	-0.6	0.0	0.9	0.9	0.1	-0.5
Heart attack/myocardial infarction (self-reported)	2.0	2.5	6.0	-1.3	-1.7	1.2	0.1	-1.9	-0.7	-2.2	-0.6	2.4	1.7	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	-0.8	-1.2	0.1	0.4	-0.8	-0.5	-1.3	0.4	-0.5	1.1	-0.8
Heart disease (siblings)	0.8	1.0	4.9	-0.2	0.1	0.6	-0.5	0.4	2.2	0.8	1.7	-0.2	1.4	0.3
Alcohol drinker status: Previous	1.6	1.8	4.3	-2.1	-1.9	2.1	1.4	-0.8	1.2	0.7	-0.7	0.5	1.4	-0.8
Pack years of smoking	0.2	0.3	1.1	-1.0	-0.5	0.2	0.0	-0.0	1.0	0.7	0.4	-0.2	-0.5	-0.1
Impedance of whole body	1.0	5.2	12.6	-1.8	-2.2	-0.9	-1.4	-2.9	-2.3	-2.9	-3.6	2.2	1.1	-2.4
Leg fat mass (left)	0.2	0.9	4.9	-0.7	-0.1	0.9	-0.5	0.1	0.9	0.7	2.2	-1.3	-0.4	-0.1
Arm predicted mass (left)	0.3	1.7	7.2	0.6	0.6	2.0	0.2	0.8	0.5	0.2	2.7	-1.1	-2.1	0.3