Hub : Genes

RAB40B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Left Ventricle 0.3273 0.0912 6.4e-07 0.299 NA 0.243 NA 0.275 2.5e-16 NA 3.7e-13 NA 5.4e-15
2 GTEx Muscle Skeletal 0.4400 0.1048 2.9e-10 0.133 NA 0.100 NA 0.128 5.5e-13 NA 5.0e-10 NA 1.6e-12
3 GTEx Nerve Tibial 0.2109 0.0629 5.1e-04 0.026 NA 0.084 NA 0.054 5.5e-03 NA 1.4e-06 NA 1.0e-04
4 GTEx Ovary 0.3120 0.1120 5.1e-03 -0.010 NA 0.039 NA 0.000 6.9e-01 NA 4.1e-02 NA 3.1e-01
5 GTEx Thyroid 0.4150 0.0840 1.4e-10 0.180 NA 0.243 NA 0.234 9.1e-14 NA 1.4e-18 NA 7.2e-18
6 TCGA Breast Invasive Carcinoma 0.0263 0.0131 5.1e-03 0.013 0.011 0.010 NA 0.009 9.0e-04 2.0e-03 2.7e-03 NA 5.4e-03
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0361 0.0195 6.8e-03 0.035 0.017 0.022 NA 0.022 6.8e-05 4.4e-03 1.4e-03 NA 1.4e-03
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.1800 0.1030 9.4e-03 0.002 0.007 0.019 NA 0.004 2.3e-01 1.2e-01 2.7e-02 NA 1.8e-01
9 TCGA Lung Squamous Cell Carcinoma 0.0447 0.0228 3.6e-03 0.017 0.012 0.010 NA 0.012 4.7e-03 1.3e-02 2.6e-02 NA 1.4e-02
10 TCGA Prostate Adenocarcinoma 0.0587 0.0262 2.6e-03 0.027 0.014 0.020 NA 0.015 7.2e-04 1.3e-02 3.3e-03 NA 8.4e-03
11 TCGA Thyroid Carcinoma 0.2340 0.0570 0.0e+00 0.176 0.188 0.230 NA 0.235 8.0e-17 5.1e-18 3.9e-22 NA 1.1e-22

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.1 0.2 0.5 0.0 -0.5 0.5 0.4 -0.5 0.3 -0.6 -0.7 0.2 0.1 -0.7
Bipolar Disorder or Schizophrenia 0.2 0.5 1.6 0.0 -0.7 -1.1 1.2 -0.2 0.6 0.1 -1.0 -1.0 0.6 0.2
Depressed Affect (Nagel 2018) 0.5 1.0 6.7 -0.7 -0.6 0.3 -0.8 -0.3 1.5 0.2 0.4 0.2 2.6 -0.1
Depression (Nagel 2018) 0.6 0.9 3.3 -1.0 -0.5 -0.7 -0.1 0.1 1.8 1.3 -0.1 0.0 1.6 0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 4.9 -0.2 0.2 0.2 -1.7 -0.4 0.1 -0.2 -0.2 -0.7 -2.2 -0.2
Neuroticism (Nagel 2018) 0.4 0.9 5.9 -0.5 -0.5 -0.3 -1.3 -0.4 1.2 -0.1 -0.4 -0.8 2.4 -0.2
Schizophrenia (2018) 0.4 0.8 3.2 0.0 -0.6 -1.8 1.2 0.1 0.4 0.6 -0.2 -1.5 0.7 0.8
Schizophrenia vs Biploar Disorder 1.7 2.2 4.2 0.0 1.6 -1.9 -0.9 1.9 1.7 2.0 1.2 -1.2 0.1 2.0
Worry (Nagel 2018) 0.4 0.9 2.9 0.1 0.4 -1.1 -1.7 0.2 1.5 0.3 -0.7 -1.3 1.0 0.3
Alzheimer’s Disease (in mother) 2.1 2.5 4.7 -1.5 -2.2 0.8 0.7 -2.1 -0.9 -2.0 -0.6 1.4 1.9 -1.9
Alzheimer’s Disease (in father) 0.9 1.0 4.1 0.6 0.5 -2.0 0.6 0.6 -1.3 0.5 0.3 -1.5 -0.7 0.9
Alzheimer’s Disease (including proxy) 0.9 1.3 5.0 -0.6 -1.3 -0.2 0.6 -1.3 -2.2 -1.4 -0.9 -0.0 1.0 -1.1
Crohns Disease (2017) 0.6 1.4 7.4 0.4 0.3 2.7 -1.3 -0.1 -0.1 0.4 0.3 0.3 -2.3 -0.0
Irritable Bowel Disease (IBD) 0.4 0.9 2.4 0.6 0.8 1.5 -0.2 0.4 1.2 1.5 1.2 0.2 -1.2 0.5
Ulcerative Colitis (UC) 0.7 1.3 2.9 1.4 1.7 -0.6 0.2 1.0 1.4 1.4 1.7 0.4 0.0 1.1
Major Depression (MDD) 2.3 2.7 7.2 -2.4 -2.2 0.1 0.7 -2.7 -0.5 -1.9 -0.9 -0.4 0.0 -2.7
Reaction Time 0.2 0.3 0.8 -0.7 -0.7 0.5 0.9 -0.6 -0.5 -0.4 0.6 -0.4 -0.1 -0.6
Verbal and Numeric Reasoning (VNR) 0.3 0.7 5.6 -0.5 -0.0 0.4 -0.6 -0.4 0.7 0.3 0.1 -2.4 -0.9 -0.1
Breast Cancer 1.7 4.2 13.6 -1.8 -2.5 1.1 1.4 -2.9 -1.8 -3.7 -0.4 -0.1 0.8 -2.7
Ovarian Cancer 1.1 1.4 3.0 1.7 1.7 -0.9 0.6 1.6 0.3 0.9 1.0 -0.6 -0.8 1.6
Prostate Cancer 0.4 0.5 1.5 0.2 -0.0 0.3 -1.2 -0.6 -1.1 0.2 0.4 -0.9 -1.2 -0.0
Age at First Birth 0.5 0.7 3.2 -0.1 -0.0 -0.1 -1.8 -0.8 -0.6 -0.9 -1.1 0.8 -0.3 -0.5
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.1 0.1 0.4 -0.8 0.2 1.0 0.2 1.1 -1.0 -1.1 -0.2 0.8
Coronary Artery Disease (CAD) 0.4 0.5 2.1 0.0 0.7 0.5 0.4 0.4 0.4 0.1 1.3 0.7 -1.4 -0.2
Crohns Disease (2012) 1.3 2.0 13.1 0.1 0.2 2.4 -0.7 -0.5 -0.9 -0.5 1.3 -0.0 -3.6 -0.4
Mean Putamen Volume 1.2 1.4 4.5 -1.6 -1.6 1.0 1.0 -0.7 0.2 0.1 -1.5 -0.5 2.1 -0.9
Fasting Glucose 2.3 2.8 7.1 1.3 2.0 -1.8 -1.2 2.0 1.9 2.7 0.9 -0.1 0.9 2.0
HbA1C 2.1 2.4 12.6 0.0 -0.1 -0.0 0.6 -0.6 1.6 -2.1 1.0 3.5 -1.6 -1.5
HDL Cholesterol 1.0 1.7 3.6 -1.7 -1.8 1.0 0.1 -1.9 0.4 -1.7 0.1 -0.1 0.9 -1.9
LDL Cholesterol 0.7 1.1 3.0 1.0 1.0 -0.6 1.1 1.7 -0.1 1.5 -0.1 -0.3 -0.8 1.5
Lupus 0.4 0.7 3.6 0.4 0.4 0.8 -1.9 -0.3 -0.9 0.1 0.0 0.7 -1.2 -0.2
Neuroticism (2016) 0.5 0.7 2.5 -0.2 0.0 -1.4 -1.6 0.6 0.2 0.7 -1.3 -0.4 0.4 0.4
Primary Biliary Cirrhosis 1.3 1.8 4.1 1.1 1.3 -2.0 0.6 1.8 1.1 1.8 1.1 -0.5 -0.1 1.8
Rheumatoid Arthritis 0.2 0.3 1.2 0.1 0.3 0.3 -0.4 0.5 -0.5 1.1 0.6 0.6 -0.6 0.6
Schizophrenia (2014) 0.6 1.4 3.8 0.0 0.3 -2.0 0.9 1.1 0.5 1.7 -0.0 -1.5 0.3 2.0
Triglycerides 0.3 0.5 1.9 0.7 0.7 -0.7 0.4 0.8 0.0 0.4 0.1 -0.3 1.4 0.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.7 0.0 1.1 -1.2 -1.6 0.4 -0.9 -0.5 -0.9 0.4 -0.9 0.3
Ulcerative Colitis 0.5 0.8 2.8 0.0 1.2 -0.3 0.4 0.7 0.9 1.0 1.7 0.0 -1.3 0.6
Blood Eosinophil Count 0.2 1.3 8.7 -0.5 -0.2 1.1 -0.8 -0.9 -0.0 -1.2 -0.4 3.0 0.4 -1.0
Blood Platelet Count 0.9 10.0 16.7 -4.1 -3.9 2.8 3.3 -3.0 -2.2 -3.4 -4.1 -0.2 -1.4 -4.0
Blood Red Count 0.9 8.5 32.8 2.1 2.8 0.8 -5.7 2.5 1.7 2.8 3.9 -1.6 -2.0 2.9
Blood White Count 0.1 0.9 4.4 0.2 0.2 -0.8 1.5 0.2 -1.1 -0.2 1.1 0.5 -2.1 0.2
Heel T-Score 0.1 0.5 1.8 0.3 0.2 0.9 -1.3 -0.3 -1.0 0.3 1.2 -0.1 -0.8 0.3
BMI 0.2 1.4 3.8 -0.6 0.0 1.9 1.3 0.6 1.2 1.1 1.9 -1.5 -1.0 0.1
Height 0.2 4.8 17.7 1.3 0.8 2.7 -4.2 -0.3 -0.6 -2.6 -0.2 2.1 -3.5 -1.0
Waist Hip Ratio (WHR) 0.1 0.6 4.3 -0.4 0.2 0.3 -0.2 -0.1 2.1 0.0 0.1 1.3 0.8 -0.2
Systolic Blood Pressure 0.1 0.4 1.2 -0.4 -0.1 -0.6 1.1 0.5 -0.3 0.7 -1.1 -0.4 -0.0 0.4
Smoking Status 0.3 0.8 3.4 -0.9 -0.6 1.1 1.9 -0.7 0.7 -0.6 0.4 0.4 0.2 -1.0
Allergy or Eczema 0.5 1.3 5.5 -0.6 -0.3 1.5 -2.4 -0.9 1.4 -1.1 -0.3 0.7 0.7 -1.0
Cardiovascular Disease 0.1 0.5 1.4 -0.8 -1.2 0.5 0.5 -0.5 -0.0 -0.5 -1.0 -0.6 0.7 -0.5
Hypothyroidism (self reported) 1.0 2.4 7.6 1.3 1.3 0.4 -1.5 1.4 2.8 0.8 0.3 1.7 2.4 1.1
Respiratory disease 1.1 2.5 5.5 -1.8 -1.5 0.3 2.3 -1.5 0.4 -1.6 -1.3 2.2 1.0 -1.8
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.6 -0.6 -0.3 0.5 -0.1 0.4 0.4 -0.0 0.8 -0.3 -0.1
Lung FEV1/FVC ratio 0.2 1.2 2.7 -1.0 -1.0 1.2 -0.6 -0.7 1.4 -0.5 -0.6 1.6 1.5 -1.1
Lung FVC 0.4 1.9 4.6 1.6 1.6 -2.1 1.1 1.7 0.4 1.5 1.0 0.1 0.0 1.8
Neuroticism 0.2 0.6 3.1 -0.2 -0.3 -0.3 -0.6 -0.4 0.7 -0.5 -0.3 -1.2 1.8 -0.2
Chronotype (morning person) 1.0 2.3 7.1 -1.7 -1.8 2.7 -0.2 -1.8 -1.2 -1.6 -0.6 0.6 -0.8 -1.9
Hair Pigment 0.5 14.8 30.7 -4.8 -5.5 -0.2 4.6 -4.4 -1.9 -2.7 -3.3 -4.4 3.4 -3.8
Tanning 0.4 5.2 10.9 2.8 3.1 -3.3 -1.2 3.0 1.9 2.4 1.0 0.1 -0.6 2.8
Hand grip strength (left) 0.6 1.6 5.3 1.4 2.0 0.7 -0.6 1.5 0.4 1.0 0.9 0.5 -2.3 1.0
Number of treatments/medications taken 0.8 1.5 5.1 -0.9 -1.0 0.8 -0.6 -1.1 -0.2 -1.6 -2.2 1.2 1.1 -1.3
Average weekly spirits intake 0.9 1.1 4.4 1.0 1.0 0.5 -1.6 0.6 0.3 0.1 1.4 2.1 -0.3 0.6
Sensitivity / hurt feelings 0.5 0.8 3.2 -0.0 -0.1 -0.3 -1.3 0.3 0.3 0.2 -1.6 -1.1 1.8 0.5
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.5 -0.9 -0.6 -1.2 -0.5 -0.6 1.0 -0.1 -0.3 -0.2 0.2 -0.6
Hearing difficulty/problems: Yes 0.6 1.0 4.6 -0.1 0.0 -1.0 0.0 -0.7 1.2 -0.6 2.1 0.4 1.6 -0.4
Relative age of first facial hair 1.1 2.4 4.7 -1.4 -1.9 0.6 1.3 -2.0 -2.2 -2.0 -1.1 0.9 -0.2 -1.9
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.5 1.9 1.8 -1.5 -0.9 1.7 1.1 0.9 1.0 -0.8 -0.6 1.7
Ever used hormone-replacement therapy (HRT) 0.5 0.6 5.7 -0.2 -0.6 -0.6 0.3 -0.2 0.3 -0.0 0.3 0.2 2.4 0.0
Ever had hysterectomy (womb removed) 0.2 0.3 1.1 -0.0 -0.3 -0.2 0.1 -0.6 -0.9 -1.0 -0.2 -0.2 0.5 -0.4
Systolic blood pressure, automated reading 0.1 0.2 0.9 -0.3 -0.0 -0.0 -0.3 -0.1 -0.9 -0.5 -0.3 0.3 -1.0 -0.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.7 0.5 0.7 -0.1 0.8 1.3 1.6 1.6 1.0 -0.6 0.9 1.3
Angina 0.7 0.9 3.5 -0.1 -0.8 -0.3 0.6 -0.8 -1.1 -1.9 -0.7 1.2 0.9 -1.0
Medication for hormone replacement therapy 0.6 0.7 2.7 -0.8 -0.9 0.1 -0.4 -0.6 1.5 -0.1 0.3 0.3 1.7 -0.6
Vitamin and mineral supplements 0.4 0.6 2.9 0.4 0.9 -1.3 0.2 0.2 0.0 0.4 0.5 0.1 -1.7 0.2
Supplements: Zinc 1.3 1.5 3.4 -1.7 -1.9 1.5 0.4 -1.5 0.5 -1.2 -0.1 0.4 0.7 -1.6
Medication: Co-codamol 0.7 0.8 1.8 -0.9 -0.8 0.4 1.3 -1.0 0.7 -1.4 0.6 0.3 0.5 -1.2
Medication: Metformin 0.3 0.5 1.8 -1.3 -0.9 0.8 0.4 -0.3 0.9 0.3 -0.4 0.6 -0.2 -0.6
Diabetes (father) 0.4 0.4 2.1 0.0 0.1 -0.4 -1.1 -0.4 0.6 -0.5 1.4 0.7 -0.5 -0.4
Diabetes (mother) 0.9 1.2 2.6 1.2 1.2 -1.6 -0.7 1.1 0.7 1.3 0.5 1.0 0.2 1.5
Severe depression (siblings) 1.0 1.1 2.2 -1.2 -1.1 0.9 -1.0 -1.3 0.3 -1.2 -0.1 1.0 -1.4 -1.5
Pack years adult smoking proportion 0.2 0.3 1.3 -1.1 -0.6 0.3 0.2 -0.1 1.1 0.6 0.3 -0.2 -0.4 -0.3
Impedance of leg (right) 0.7 3.5 10.3 -1.8 -1.7 -1.7 -1.1 -2.3 -1.6 -1.9 -3.2 1.0 1.2 -1.9
Leg fat-free mass (left) 0.5 2.5 10.3 1.0 1.1 1.8 0.8 1.4 1.1 0.8 3.2 -1.4 -2.2 0.8
Trunk fat percentage 0.1 0.5 1.3 -1.1 -0.8 0.9 -0.9 -0.6 0.4 0.1 0.7 -0.6 0.3 -0.6
Hand grip strength (right) 0.4 1.2 5.5 0.2 0.6 1.9 -0.2 0.0 -1.0 -0.3 -0.4 1.3 -2.3 -0.5
Townsend deprivation index at recruitment 0.7 0.9 5.6 0.3 -0.1 -0.6 2.4 0.2 0.3 0.0 0.2 -2.0 0.5 0.2
Current tobacco smoking 0.5 0.8 2.8 -0.5 -0.4 1.6 1.7 -0.6 0.2 -1.1 -0.8 0.1 -0.1 -0.9
Average weekly fortified wine intake 1.6 1.9 4.6 -1.4 -1.4 1.6 -1.1 -1.6 -0.2 -1.6 -0.6 2.2 0.8 -1.6
Maternal smoking around birth 0.2 0.2 0.6 -0.4 -0.5 0.5 0.5 -0.6 -0.5 -0.1 -0.0 0.8 0.5 -0.4
Fed-up feelings 0.4 0.7 1.7 -1.0 -1.0 1.1 -0.3 -0.9 0.1 -0.6 1.3 0.0 0.8 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.4 -1.1 -0.8 -1.2 0.0 -0.4 0.3 0.2 0.1 -0.9 0.7 -0.3
Relative age voice broke 0.8 1.3 2.2 -1.2 -1.3 1.2 0.1 -0.9 -1.4 -1.1 -1.5 1.2 -0.7 -1.1
Taking other prescription medications 1.1 1.6 6.7 -1.3 -1.1 1.4 -0.5 -0.8 1.0 -1.0 -0.8 1.3 2.6 -1.1
Age when periods started (menarche) 0.3 0.6 1.2 -0.7 -0.9 0.2 1.1 -0.6 0.5 -0.9 -0.1 0.9 1.1 -0.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.2 -0.3 -0.4 0.2 -0.7 -0.4 1.1 -0.1 -0.2 -0.9 0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 2.1 0.8 0.6 1.4 -0.3 0.7 -0.4 0.5 -1.3 -0.2 -0.3 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.0 -0.7 -0.5 -0.2 -0.3 0.5 1.4 1.2 1.1 -0.9 -0.0 0.2
Qualifications: CSEs or equivalent 1.2 1.6 4.5 1.5 1.6 -2.1 -0.1 1.0 1.1 0.7 1.8 -1.2 0.3 1.1
Serious illness, injury or assault to yourself 1.7 2.1 4.3 -1.7 -2.1 1.6 1.4 -1.5 -1.2 -1.1 1.7 0.4 -0.9 -1.6
High blood pressure 0.2 0.7 1.8 -0.4 -0.8 0.0 0.4 -0.6 0.0 -1.3 -1.1 -1.4 0.9 -0.6
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.6 -0.3 -0.2 1.2 -1.6 -0.7 0.3 -1.4 -1.1 -0.4 -0.1 -0.9
Multivitamins +/- minerals 0.2 0.3 1.2 0.1 -0.4 1.1 -1.0 -0.2 -0.2 -0.2 0.3 0.2 0.8 -0.0
Stomach or abdominal pain in last month 0.4 0.5 2.3 -0.1 -0.2 -0.3 1.1 -0.2 0.1 -0.4 1.5 -1.0 -0.4 -0.2
Supplements: Glucosamine 0.7 0.9 2.4 -0.1 -0.5 1.1 -0.5 -0.9 -1.5 -1.6 -0.5 1.1 -0.4 -1.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.2 0.7 0.8 -1.4 -1.5 0.6 -0.5 0.7 -0.0 0.5 -0.7 0.8
Medication: Atenolol 0.9 1.2 3.2 1.3 1.1 -1.3 -1.5 0.2 -1.3 -0.9 -1.8 0.1 -0.4 0.3
Medication: Levothyroxine sodium 1.0 1.8 7.3 0.2 0.7 0.3 -2.7 0.3 2.3 0.2 -1.1 1.2 1.8 0.1
Sitting height 0.3 1.9 5.8 0.8 -0.1 2.2 0.8 -0.5 -1.7 -2.4 -0.0 1.3 -1.9 -1.0
Chronic bronchitis/emphysema (father) 1.0 1.2 9.7 0.5 0.1 1.0 0.5 -0.1 0.0 -0.8 3.1 1.0 0.5 -0.1
High blood pressure (mother) 0.9 1.3 2.7 -1.2 -1.6 0.6 0.9 -1.5 -0.7 -1.5 1.2 0.5 0.7 -1.3
Body mass index (BMI) 0.4 1.9 7.8 0.0 0.7 0.8 0.0 1.1 1.4 1.7 2.8 -2.1 -0.8 0.9
Impedance of leg (left) 1.0 5.1 12.7 -1.7 -1.9 -1.3 -1.7 -2.9 -2.5 -2.7 -3.6 1.8 1.2 -2.3
Leg predicted mass (left) 0.4 2.3 10.0 0.8 0.9 1.9 0.9 1.2 1.0 0.7 3.2 -1.4 -2.1 0.6
Trunk fat mass 0.1 0.6 2.2 -0.7 -0.3 1.3 -0.8 -0.2 0.5 0.2 1.5 -0.8 -0.6 -0.4
Waist circumference 0.3 1.1 6.2 0.0 0.5 1.3 -0.3 0.6 1.3 0.5 2.5 -0.6 -1.0 0.2
Number of incorrect matches in round 1.1 1.8 8.0 -0.7 -0.9 -0.7 0.9 -0.7 -1.7 -0.9 -2.2 -2.8 -0.5 -0.7
Past tobacco smoking 0.5 0.9 3.0 0.7 0.7 -0.9 -1.7 1.0 1.1 1.3 -0.4 -0.3 -0.1 1.2
Alcohol usually taken with meals 0.8 1.3 4.0 0.2 -0.3 2.0 -1.0 -0.9 -0.8 -1.5 0.3 1.6 1.3 -0.7
Nervous feelings 0.3 0.5 1.9 0.0 0.2 -0.6 -0.6 -0.2 0.2 -0.6 -1.2 -1.4 -1.1 -0.2
Frequency of tenseness / restlessness in last 2 weeks 1.3 1.9 3.6 -1.7 -1.9 -1.3 1.3 -1.6 -0.3 -1.6 -1.4 -0.1 1.2 -1.6
Hearing difficulty/problems with background noise 0.8 1.2 4.3 -0.5 -0.8 -1.1 0.8 -1.6 -0.2 -2.1 0.4 0.4 1.3 -1.4
Hair/balding pattern: Pattern 2 1.1 1.5 3.4 -1.8 -1.9 0.6 1.7 -1.2 -0.6 -0.5 -1.0 0.5 1.1 -1.2
Had menopause 1.0 1.2 8.0 0.1 -0.1 0.6 -1.0 0.3 1.7 0.1 0.9 0.3 2.8 0.3
Had other major operations 0.6 0.7 6.1 -0.9 -0.6 -0.4 -2.5 -0.5 0.4 0.1 0.2 -0.4 0.2 -0.4
Forced vital capacity (FVC) 0.1 0.3 1.1 0.9 0.6 -0.7 -0.1 0.2 -0.7 -0.3 -0.0 1.0 -0.4 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 2.2 0.9 0.8 1.5 -0.7 0.7 -0.6 0.7 -1.1 0.2 -0.2 0.9
Ever unenthusiastic/disinterested for a whole week 3.5 4.3 8.3 -2.5 -2.9 1.9 1.1 -2.5 -1.7 -2.6 -1.4 1.2 0.9 -2.8
Qualifications: None of the above 0.5 1.1 5.3 -0.8 -0.8 -1.4 1.3 0.1 0.3 1.0 -0.1 -2.3 0.6 0.3
Financial difficulties in last 2 years 0.2 0.3 1.9 -0.4 -0.2 -0.6 0.7 0.1 0.0 0.6 -0.3 -1.4 -0.3 0.0
Mouth/teeth dental problems 0.3 0.5 1.1 -0.7 -0.7 0.3 -0.6 -0.9 -0.7 -0.2 -1.1 0.1 -0.9 -0.8
Heart attack 1.5 1.9 4.8 -1.0 -1.4 1.0 -0.0 -1.6 -0.6 -1.9 -0.6 2.2 1.6 -1.6
Allergy 0.5 1.2 4.5 0.5 0.6 -1.7 0.1 1.1 0.3 2.1 1.2 -0.5 -0.2 1.4
Pain all over the body in last month 1.3 1.3 2.6 -1.5 -1.6 0.6 0.9 -1.6 0.3 -0.9 1.5 -0.1 1.1 -1.3
Diabetes (self-reported) 0.2 0.3 0.8 -0.9 -0.7 -0.9 -0.1 -0.5 0.4 0.1 0.5 0.5 0.2 -0.5
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.0 -0.3 -0.3 1.4 -0.9 -0.4 0.8 -0.7 -1.3 0.8 1.1 -0.6
Medication: Ramipril 0.6 0.8 2.3 0.5 0.6 -0.7 -0.8 0.8 1.5 0.5 -1.5 -0.2 1.3 0.7
Medication: Simvastatin 0.7 1.1 2.3 -1.0 -1.1 0.4 -1.4 -1.5 -0.1 -1.4 -0.6 0.8 0.6 -1.3
Fluid intelligence score 0.2 0.4 2.8 -0.1 0.3 -0.2 -0.9 -0.1 0.2 0.3 -0.6 -1.7 -0.6 0.2
Illnesses of siblings 0.2 0.3 1.1 -0.2 -0.3 -0.5 0.3 -0.5 -1.1 -0.4 -0.5 0.7 -0.3 -0.4
Neuroticism score 0.2 0.5 1.4 -0.5 -0.4 -0.6 -0.7 -0.7 0.0 -1.1 -0.4 -1.2 0.5 -0.6
Weight 0.4 1.8 7.6 0.6 0.9 1.6 -0.8 0.9 0.6 0.6 2.8 -1.2 -2.1 0.5
Impedance of arm (right) 0.7 3.5 11.9 -1.4 -1.9 -0.4 -1.4 -2.1 -1.7 -2.0 -3.5 1.7 1.4 -1.6
Arm fat percentage (right) 0.3 1.0 2.6 -0.8 -0.2 0.8 -0.4 0.5 1.5 1.6 1.4 -1.6 0.4 0.5
Trunk fat-free mass 0.4 2.0 7.0 1.2 1.2 1.8 0.1 1.2 0.6 0.4 2.5 -0.8 -2.6 0.6
Hip circumference 0.4 1.8 7.6 0.9 1.0 1.3 -0.7 1.3 0.3 0.9 2.8 -1.3 -1.9 0.9
Time employed in main current job 2.3 2.6 5.4 1.8 2.3 -1.6 -2.0 2.0 0.9 1.7 0.9 0.8 0.4 2.0
Alcohol intake versus 10 years previously 0.9 1.3 2.9 -1.3 -1.0 1.2 1.6 -0.8 1.7 -0.9 -0.8 0.4 1.1 -1.2
Father’s age at death 0.6 0.8 2.1 1.1 1.1 1.3 0.5 0.9 -0.9 0.5 0.5 0.4 -1.4 0.8
Worrier / anxious feelings 0.4 0.7 1.7 -1.2 -1.1 0.4 -0.5 -0.9 0.3 -0.7 -0.6 -1.3 0.3 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.2 -1.8 -1.6 -0.3 1.7 -1.1 0.5 -0.8 -1.0 -0.3 -0.1 -1.4
Falls in the last year 2.7 3.6 7.6 -2.3 -2.7 -0.1 1.8 -2.6 -0.9 -2.8 0.0 0.7 0.5 -2.7
Hair/balding pattern: Pattern 3 0.7 1.1 2.2 1.2 1.5 -0.0 -1.5 1.4 0.3 1.1 0.9 0.1 -1.0 1.1
Number of live births 1.4 2.0 8.0 1.0 1.0 -1.7 0.6 1.5 0.9 1.3 2.8 -1.0 -1.1 1.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 1.4 0.6 0.4 -0.5 -0.2 0.1 -0.2 -0.2 0.3 1.2 -0.4 0.0
Pulse rate 0.3 0.6 2.0 -1.2 -1.0 1.4 0.1 -0.5 0.1 -0.2 -0.0 0.5 -0.7 -0.7
Happiness 2.1 2.5 8.2 1.8 1.9 -2.9 -2.0 1.5 -0.4 1.1 1.3 -0.3 -0.4 1.7
Noisy workplace 0.5 0.6 2.6 0.6 0.4 -1.6 0.2 0.9 0.5 0.7 0.6 0.7 0.5 0.7
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.3 -0.4 -0.3 2.1 -1.5 -0.9 -1.6 -1.4 -0.4 1.5 -0.9 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 2.3 1.5 1.5 -1.5 -1.4 0.5 -0.8 -0.3 0.0 0.2 -1.4 0.5
Mouth/teeth dental problems: Dentures 0.1 0.2 1.0 0.3 0.3 0.1 0.5 0.3 1.0 -0.2 0.6 0.1 -0.6 0.0
Asthma 1.4 2.7 5.8 -1.8 -1.6 1.3 1.5 -1.6 -0.3 -1.9 -1.8 2.4 0.1 -2.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.2 -1.5 -1.0 0.5 1.4 -1.1 0.2 -0.4 0.5 -0.5 -0.4 -1.3
Medication: Cholesterol lowering 1.9 2.9 7.7 -2.1 -2.2 1.7 0.8 -1.8 1.1 -1.5 -0.8 1.0 2.8 -1.8
Depression (self-reported) 0.9 1.1 2.1 -1.4 -1.4 0.0 0.3 -1.4 0.2 -1.4 -1.4 0.3 -0.0 -1.4
Medication: Lansoprazole 3.1 3.6 6.7 -2.3 -2.6 1.6 2.6 -2.3 -0.7 -2.1 -1.1 0.2 -0.1 -2.6
Prospective memory result 0.7 0.9 1.9 0.6 0.3 -0.7 0.8 1.1 0.6 1.4 1.3 -0.8 0.7 1.3
Lung cancer (father) 0.7 0.8 2.0 -0.8 -1.1 0.4 0.2 -1.4 -0.8 -1.3 1.3 -0.2 0.2 -1.1
Illnesses of mother 2.3 2.8 6.0 2.0 2.5 -0.8 -0.5 2.1 0.3 2.2 -0.9 -1.8 -1.5 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 3.6 1.9 1.6 -1.5 -0.4 1.3 0.8 0.4 1.7 0.4 -0.8 1.1
Pulse wave Arterial Stiffness index 0.2 0.2 1.5 0.2 0.0 0.1 -0.4 0.2 -1.2 0.5 0.6 -0.1 -0.4 0.3
Impedance of arm (left) 0.8 3.8 9.2 -1.5 -2.0 -0.1 -1.0 -2.4 -1.8 -2.4 -3.0 2.2 1.4 -2.0
Arm fat mass (right) 0.2 1.0 3.1 -0.6 -0.2 1.5 -0.1 0.4 1.1 0.9 1.8 -1.6 -0.4 0.2
Trunk predicted mass 0.4 2.0 6.8 1.2 1.2 1.9 0.1 1.2 0.6 0.4 2.5 -0.8 -2.6 0.6
Standing height 0.2 2.4 8.6 1.3 0.6 1.6 -1.6 -0.3 -1.6 -2.2 0.3 1.5 -2.9 -0.7
Length of working week for main job 0.2 0.2 0.5 -0.2 -0.5 -0.4 0.7 -0.6 -0.5 -0.7 0.3 -0.6 0.0 -0.4
Exposure to tobacco smoke at home 0.3 0.4 2.8 -0.2 -0.4 0.3 -0.1 0.2 0.9 0.1 1.7 0.5 -0.2 -0.0
Breastfed as a baby 0.6 0.7 2.2 0.4 0.7 0.5 -1.0 0.8 1.5 1.2 0.1 -0.7 -0.4 0.9
Tense / ‘highly strung’ 0.3 0.5 1.8 0.0 -0.0 -0.9 -0.9 -0.8 0.0 -1.3 -0.4 -0.8 0.1 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 6.0 -2.4 -2.4 0.6 1.4 -1.9 1.8 -1.6 -0.1 -0.1 1.5 -2.1
Hair/balding pattern: Pattern 4 0.4 1.0 1.8 0.7 1.2 -0.5 -1.2 0.8 1.4 0.9 0.9 1.2 0.6 0.8
Birth weight of first child 0.4 0.8 4.2 1.0 0.6 0.0 -0.8 0.8 0.5 -0.4 2.0 1.2 0.1 0.4
Peak expiratory flow (PEF) 0.4 1.0 2.0 1.3 1.4 -0.9 -1.3 1.1 -0.1 0.8 0.1 1.2 -0.6 0.9
Pulse wave reflection index 0.3 0.3 1.2 0.2 0.5 -0.9 -0.1 0.3 0.0 0.7 1.1 0.6 -0.3 0.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 2.4 0.2 0.0 -1.5 -0.6 -0.0 -0.6 -0.1 -0.3 -1.0 0.6 0.1
Loud music exposure frequency 0.9 1.0 3.9 -0.6 -0.8 0.7 2.0 -0.8 0.0 -0.7 1.8 -0.2 -0.6 -0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.9 1.1 1.0 0.5 -1.3 -0.2 -1.1 -1.4 0.9 -0.0 -0.9 -0.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.2 -0.2 -0.5 -0.1 -0.5 -0.2 0.2 -1.1 0.3 -0.6 1.0 -0.4
Blood clot in the leg (DVT) 0.4 0.5 1.1 -0.7 -1.1 0.0 0.1 -0.7 -0.5 -1.0 0.2 -0.6 0.9 -0.7
Medication: Paracetamol 0.7 1.1 2.4 1.2 1.2 -1.5 0.0 1.1 -0.2 0.8 0.4 -1.5 -1.2 1.1
Headache pain in last month 0.4 0.7 3.0 -0.5 -0.4 -0.1 0.9 0.3 1.7 0.2 0.6 -0.4 1.6 0.1
Medication for cholesterol, blood pressure or diabetes 2.4 4.0 7.8 2.7 2.8 -2.5 -1.6 2.3 -0.4 1.8 1.2 -0.9 -1.9 2.3
Glaucoma (self-reported) 0.3 0.4 1.2 0.5 0.3 -0.7 -0.8 0.2 -0.8 -0.2 -1.1 -0.7 -0.1 0.3
Gout (self-reported) 0.6 0.9 3.0 -1.1 -0.9 1.7 1.2 -0.8 0.4 -0.5 -1.1 -0.2 0.1 -0.8
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 5.7 1.3 1.3 0.6 -2.1 1.1 2.4 0.4 0.2 2.0 2.0 0.8
Medication: Amlodipine 0.9 1.2 4.3 -1.0 -1.1 0.6 2.1 -0.7 -0.4 -1.4 -1.5 0.4 0.4 -1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 2.1 0.5 0.8 0.0 1.5 0.4 -0.6 -0.4 -0.2 1.0 -0.3 0.1
Birth weight 0.4 0.8 4.2 -0.7 -0.8 0.1 0.9 -0.0 0.4 0.1 -2.0 0.5 1.4 -0.2
Chronic bronchitis/emphysema (mother) 0.6 0.7 3.3 0.0 -0.6 0.7 -1.3 -0.4 -0.0 -0.9 1.8 0.5 0.8 -0.5
High blood pressure (siblings) 0.3 0.4 1.8 0.6 0.4 1.0 0.2 0.3 0.2 -0.5 1.3 -0.3 -0.8 0.1
Forced vital capacity (FVC), Best measure 0.3 1.1 2.7 1.6 1.4 -1.6 -0.1 0.8 0.0 0.0 1.6 0.2 -1.2 0.8
Body fat percentage 0.1 0.5 1.3 -1.0 -0.5 0.5 -0.7 -0.3 0.7 0.5 1.1 -0.9 0.4 -0.3
Leg fat percentage (right) 0.3 1.0 3.4 -1.1 -0.3 0.1 -0.5 0.1 1.4 1.2 1.9 -1.5 0.4 -0.0
Arm fat-free mass (right) 0.4 1.9 8.4 0.8 0.8 2.0 0.5 0.6 0.4 -0.1 2.9 -0.9 -2.5 0.0
Exposure to tobacco smoke outside home 0.3 0.5 1.9 -0.9 -0.8 0.3 1.4 -0.4 0.7 -0.1 -0.4 -0.3 -0.5 -0.6
Comparative body size at age 10 0.1 0.3 1.1 -0.5 -0.3 0.2 -0.8 -0.0 1.0 0.5 0.2 -0.6 0.4 -0.1
Number of full brothers 1.3 1.6 3.9 0.5 0.4 -2.0 1.9 1.2 1.3 1.0 -0.4 -1.4 1.3 1.1
Worry too long after embarrassment 0.7 1.2 2.5 -0.9 -1.2 -1.0 1.2 -1.2 -0.2 -1.6 -0.5 -0.7 1.6 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.1 -0.9 -1.0 0.9 0.4 -0.6 1.8 -0.5 0.9 -0.3 0.8 -0.7
Wheeze or whistling in the chest in last year 2.1 3.7 8.9 -2.9 -2.3 1.4 0.9 -2.8 -0.3 -2.0 -1.7 0.9 -0.3 -3.0
Number of children fathered 1.0 1.2 4.1 0.5 0.3 -1.9 -0.6 0.1 -1.8 0.0 -2.0 -0.2 0.8 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 4.0 -0.7 -0.9 0.2 1.0 -0.5 1.7 -0.7 -0.7 1.2 2.0 -0.7
Age at first live birth 0.5 0.8 4.0 0.1 0.2 0.7 -2.0 -0.3 0.1 -0.6 -1.6 1.2 -0.3 -0.4
Pulse wave peak to peak time 0.1 0.2 1.0 0.0 0.1 -0.1 0.2 -0.1 1.0 -0.6 -0.6 0.1 0.1 -0.2
Health satisfaction 0.2 0.3 1.0 -0.9 -1.0 -0.2 -0.4 0.2 -0.1 0.4 0.0 -0.7 0.7 0.1
Shortness of breath walking on level ground 0.6 0.7 2.6 -1.0 -0.8 0.2 0.1 -0.8 0.9 -0.8 0.3 0.1 1.6 -0.9
Qualifications: College or University degree 0.9 3.0 6.7 -0.6 -0.7 1.9 -2.4 -1.7 -1.9 -2.1 -1.5 2.6 0.2 -1.5
Eye problems/disorders: None of the above 0.3 0.4 1.2 0.7 0.2 0.7 -0.4 -0.3 -1.1 -1.0 0.3 0.7 -0.2 -0.2
Mouth/teeth dental problems: Loose teeth 2.1 2.5 5.2 -1.1 -1.1 0.8 -0.2 -2.0 -2.0 -2.3 -2.2 0.1 -1.4 -2.0
Emphysema/chronic bronchitis 2.0 2.3 6.3 -1.5 -1.5 1.6 1.7 -1.3 1.1 -1.3 0.8 2.5 0.7 -1.6
Medication for pain relief, constipation, heartburn 0.2 0.3 1.5 0.1 -0.0 -0.4 -0.4 -0.4 -0.1 -0.3 1.2 1.2 -0.3 -0.3
Neck or shoulder pain in last month 0.2 0.3 1.4 -0.0 -0.4 0.0 1.2 -0.3 0.2 -0.8 0.9 0.1 -0.6 -0.5
Medication: Blood pressure 0.7 1.3 2.9 -1.1 -1.1 1.5 1.7 -1.0 0.5 -1.1 -0.9 0.8 1.2 -1.1
Angina (self-reported) 0.7 0.9 3.1 -0.2 -0.9 -0.2 0.7 -0.8 -1.1 -1.8 -0.9 1.0 0.8 -1.0
Migraine (self-reported) 1.5 1.8 5.7 -2.4 -2.1 1.4 0.9 -1.8 -0.4 -0.8 -0.3 -0.3 0.4 -1.7
Medication: Ibuprofen 0.2 0.3 1.1 -0.6 -0.1 0.6 0.0 -0.5 -0.1 -0.4 0.4 0.0 -1.1 -0.7
Medication: Allopurinol 0.3 0.4 1.2 -0.3 0.2 0.7 0.4 0.2 1.1 0.8 -0.8 -0.7 0.3 0.3
Medication: Omeprazole 1.0 1.2 2.6 -1.0 -1.3 -0.2 1.1 -1.2 -1.2 -1.6 -0.5 -1.0 -0.9 -1.3
Medication: Seretide 50 evohaler 0.1 0.1 0.4 0.3 0.5 -0.7 -0.1 0.2 0.2 0.4 0.1 0.2 -0.3 0.3
Mean time to correctly identify matches 0.1 0.2 0.8 -0.9 -0.5 0.5 0.3 -0.4 0.4 0.1 0.7 0.3 0.2 -0.5
Heart disease (mother) 1.4 1.7 5.0 -1.0 -1.1 0.4 -1.0 -1.6 -1.0 -2.2 -0.4 1.7 -0.4 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.8 0.5 0.1 -0.7 -0.9 0.0 -0.4 -0.2 -0.5 -0.4 0.2 0.1
Whole body fat mass 0.2 0.7 3.5 -0.8 -0.3 1.4 -0.4 -0.1 0.8 0.5 1.9 -1.0 -0.4 -0.3
Leg fat mass (right) 0.3 1.0 5.2 -0.7 -0.1 0.8 -0.1 0.3 1.2 0.9 2.3 -1.5 -0.5 -0.0
Arm predicted mass (right) 0.4 1.9 8.4 1.0 1.0 1.7 0.4 0.9 0.6 0.1 2.9 -0.8 -2.3 0.3
Pulse rate, automated reading 0.2 0.5 2.3 -0.2 0.1 0.5 0.6 1.0 1.5 0.9 -0.3 0.6 0.1 0.5
Alcohol intake frequency. 0.5 1.1 3.1 -1.0 -0.6 1.1 1.1 0.3 1.4 1.7 0.2 -1.8 -0.1 0.4
Comparative height size at age 10 0.5 2.8 6.1 2.4 2.5 -0.5 -2.4 1.7 -0.1 0.7 1.1 0.1 -2.5 1.4
Number of full sisters 2.1 2.5 15.5 -0.5 -0.9 -1.6 1.3 0.1 1.3 0.0 -1.9 -1.1 3.9 0.2
Suffer from ‘nerves’ 0.3 0.4 1.6 0.4 0.6 -1.1 -1.3 0.2 0.1 0.1 -0.4 -0.9 -0.6 0.2
Overall health rating 0.4 0.9 2.2 -1.3 -1.2 0.1 -0.8 -1.4 0.7 -1.2 -0.4 0.0 0.3 -1.5
Chest pain or discomfort 1.1 1.6 3.8 -1.3 -1.3 1.4 -0.4 -1.4 -0.2 -2.0 0.3 1.7 -0.7 -1.8
Had major operations 1.3 1.6 5.0 0.1 -0.7 0.7 0.6 -1.1 -2.2 -2.1 -0.9 1.2 -1.3 -1.1
Age at last live birth 0.5 0.8 3.1 0.5 1.0 -0.7 -1.8 0.1 0.4 0.1 0.5 -0.2 -1.7 0.1
Family relationship satisfaction 0.3 0.4 1.2 -0.4 -0.7 -0.5 -0.5 -0.7 -0.7 -0.6 -0.8 1.1 -0.1 -0.6
Leg pain on walking 0.7 0.8 2.7 -0.6 -0.7 0.5 -1.6 -1.2 -0.4 -1.3 -0.0 0.8 -0.4 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.2 0.7 0.3 -0.3 0.4 0.7 -0.5 0.6 1.1 0.3 -0.5 0.7
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.7 -0.5 -0.7 -0.2 -0.0 -1.5 -0.8 -1.7 1.6 1.9 -1.1 -1.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 3.9 0.2 0.3 0.2 -1.0 0.6 1.1 0.8 -1.0 0.1 2.0 0.8
Medication: Aspirin 0.5 0.7 2.7 -0.6 -0.6 1.6 -0.5 -0.3 0.8 -0.6 -0.3 1.1 1.2 -0.6
Supplements: Vitamin C 1.3 1.5 3.8 -1.5 -2.0 1.2 0.4 -1.4 0.3 -1.3 -0.1 0.3 1.8 -1.3
Knee pain experienced in last month 1.0 1.6 4.9 1.8 1.6 -2.2 -0.2 1.5 -0.2 0.4 0.8 -0.7 -0.9 1.4
Hypertension (Self-reported) 0.2 0.5 2.0 -0.2 -0.6 -0.2 0.6 -0.4 0.2 -1.0 -0.6 -1.2 1.4 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.9 0.4 -0.2 -0.3 1.0 -0.3 -0.6 -1.7 -1.0 -1.3 0.5 -0.6
Illnesses of father: Heart disease 0.4 0.6 3.6 0.2 0.1 -1.2 -1.9 -0.4 -0.5 -1.0 0.0 -0.0 -0.1 -0.2
Illnesses of siblings: Diabetes 0.5 0.6 2.8 0.1 0.3 -1.0 -0.8 0.1 0.2 0.5 -1.2 -1.7 0.1 0.3
Smoking status: Previous 0.5 0.7 2.4 -0.6 -0.9 -0.3 0.5 -1.0 -1.6 -1.1 0.4 0.3 0.4 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 5.7 0.7 0.6 0.5 -0.4 0.2 0.1 -0.9 0.9 0.3 -2.4 -0.2
Whole body fat-free mass 0.4 2.1 7.4 1.1 1.1 2.1 0.4 1.1 0.6 0.4 2.7 -1.0 -2.5 0.6
Leg fat-free mass (right) 0.4 2.3 9.4 1.2 1.0 2.0 0.8 1.2 0.6 0.3 3.1 -1.0 -2.3 0.6
Arm fat percentage (left) 0.2 0.9 2.2 -0.8 -0.2 1.0 -0.3 0.3 1.2 1.3 1.5 -1.4 0.2 0.2
Average weekly red wine intake 2.6 3.8 8.9 -1.8 -2.0 3.0 -0.5 -2.1 -1.3 -2.5 -0.5 2.7 0.4 -2.3
Handedness (chirality/laterality): Left-handed 1.4 1.7 5.0 2.1 2.2 -0.9 -1.0 1.3 -0.4 0.3 0.6 -0.8 -1.5 1.4
Mood swings 0.2 0.4 1.1 -0.6 -0.7 0.5 0.8 -0.4 -0.1 -0.3 0.5 1.0 1.0 -0.5
Loneliness, isolation 0.1 0.2 1.1 -0.3 -0.1 0.1 -1.0 -0.2 0.2 -0.2 0.4 0.1 -0.4 -0.3
Long-standing illness, disability or infirmity 0.3 0.5 1.7 0.5 0.3 -0.7 0.5 0.7 1.1 0.2 0.3 0.5 1.3 0.5
Ever had bowel cancer screening 1.2 1.4 5.5 0.2 0.1 -0.7 0.1 -0.5 -0.9 -0.5 2.4 -2.1 -1.8 -0.2
Diabetes diagnosed by doctor 0.1 0.2 1.1 -0.5 -0.3 -1.1 -0.1 0.1 0.7 0.6 0.1 -0.2 0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 3.4 -1.1 -1.0 0.2 1.8 -0.8 0.1 -0.4 -0.3 0.4 0.5 -1.0
Friendships satisfaction 0.4 0.5 2.4 0.0 0.4 -1.6 -1.3 0.2 -0.0 0.7 0.1 -0.7 0.3 0.4
Qualifications: nursing, teaching 1.5 2.4 5.1 -1.4 -1.3 1.1 -0.8 -2.0 -0.9 -2.3 -1.4 2.1 0.2 -2.0
Commuting to job workplace: Walk 3.3 3.6 8.5 2.0 2.5 -1.2 -0.8 2.8 1.5 2.9 0.5 -0.3 0.5 2.8
Eye problems/disorders: Cataract 0.4 0.4 1.2 -0.4 -0.1 0.9 1.0 0.1 1.1 0.7 -0.8 0.6 0.6 0.0
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.2 1.0 1.0 -0.7 0.7 2.0 0.7 2.0 0.7 -0.2 1.1 2.0
Medication for cholesterol 0.7 1.0 3.5 0.6 0.9 0.8 1.5 0.7 -0.9 0.3 1.3 0.1 -1.9 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.6 3.1 -0.0 0.1 -0.8 0.9 0.6 1.8 0.8 -0.3 0.2 1.1 0.3
Back pain experienced in last month 0.6 0.9 4.1 -1.0 -0.8 0.9 0.3 -0.4 0.9 -0.6 2.0 0.9 -0.2 -0.7
Mineral and other dietary supplements 0.8 1.1 3.1 1.0 1.2 -1.8 0.0 1.0 0.1 1.1 0.9 -1.1 -1.3 1.0
Breast cancer (self-reported) 1.7 2.0 5.8 -2.4 -2.0 1.1 0.8 -1.9 -0.1 -1.5 0.0 0.2 -0.1 -2.1
Asthma (self-reported) 1.9 3.7 6.8 -2.1 -2.0 1.4 1.7 -2.1 -0.6 -2.3 -2.0 2.6 0.2 -2.6
Osteoporosis (self-reported) 0.9 1.1 3.4 -0.3 -0.4 -0.2 -0.5 -0.8 -1.6 -0.9 -1.8 -0.9 -1.7 -0.9
Osteoarthritis (self-reported) 0.8 1.1 3.2 0.2 0.3 -0.3 -1.8 -0.6 -0.9 -0.8 1.2 -1.3 -1.8 -0.3
Medication: Aspirin 0.3 0.4 1.9 -0.1 -0.2 1.4 -0.7 -0.2 0.4 -0.7 0.1 0.9 0.8 -0.4
Medication: Gliclazide 0.7 0.8 3.9 0.2 0.5 -1.1 -1.6 0.5 -0.3 0.7 -2.0 -0.0 0.1 0.4
Illnesses of father: None of the above (group 1) 0.9 1.1 2.9 0.2 0.5 -0.8 0.7 0.9 1.4 1.7 -0.5 -1.2 1.5 1.0
Smoking status: Current 0.5 0.7 3.6 -0.4 -0.1 1.9 1.4 -0.4 0.6 -0.8 -0.7 0.4 -0.1 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.6 0.6 0.4 -1.4 0.4 1.2 1.2 1.6 1.6 -0.4 0.1 1.3
Whole body water mass 0.4 2.1 7.6 1.1 1.0 2.1 0.3 1.1 0.6 0.3 2.8 -0.9 -2.5 0.5
Leg predicted mass (right) 0.4 2.2 9.2 1.2 1.0 2.0 0.7 1.1 0.5 0.2 3.0 -1.1 -2.3 0.6
Arm fat mass (left) 0.3 1.2 4.7 -0.5 -0.1 1.6 -0.0 0.5 1.1 1.1 2.2 -1.6 -0.5 0.3
Number of self-reported non-cancer illnesses 1.4 2.5 7.3 -1.3 -1.4 0.9 -0.1 -1.9 0.1 -2.7 -1.0 2.4 0.9 -2.1
Average weekly champagne plus white wine intake 0.7 1.0 2.8 0.1 -0.1 1.7 -1.5 -0.9 -1.3 -1.3 -0.7 -0.3 -1.0 -0.6
Miserableness 0.1 0.2 0.5 0.2 0.4 -0.7 0.6 0.3 -0.1 -0.1 0.7 -0.6 -0.3 0.2
Guilty feelings 0.5 0.7 4.3 -0.5 -0.5 0.0 0.4 -0.8 -0.9 -0.9 -0.3 -2.1 0.0 -0.6
Wears glasses or contact lenses 1.5 1.8 11.1 1.3 1.7 -0.2 -3.3 0.7 -0.6 -0.1 -0.6 1.3 -0.7 0.7
Ever taken oral contraceptive pill 0.9 1.0 6.3 1.3 1.1 -0.5 -0.6 0.2 -0.5 -0.6 -0.1 2.5 -0.0 0.2
Hearing aid user 0.4 0.4 1.5 -0.1 -0.0 -0.3 1.1 0.2 0.9 -0.1 0.2 -1.2 0.8 0.2
Mother’s age at death 0.4 0.5 3.5 0.1 0.0 0.7 -0.1 0.3 1.0 0.5 1.9 -0.2 0.4 0.2
Financial situation satisfaction 0.2 0.2 1.1 0.1 0.1 0.2 1.0 0.3 -0.0 0.0 -0.2 -0.6 -0.7 -0.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 4.3 2.1 1.6 -0.6 -1.9 1.1 -0.1 -0.2 0.4 1.3 -0.6 1.2
Commuting to job workplace: Public transport 0.7 0.8 2.5 0.6 0.8 -0.1 0.3 1.3 0.5 1.2 -1.6 -0.9 0.1 1.1
Eye problems/disorders: Glaucoma 0.4 0.5 2.1 0.4 0.3 -1.4 -1.0 -0.0 -1.0 -0.2 -0.3 -0.7 -0.3 0.2
Medication: Blood pressure 0.5 0.9 5.2 -0.2 -0.6 -1.1 -0.3 -0.2 -0.3 -0.3 -2.3 -1.3 1.1 -0.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.4 -0.7 -0.9 0.1 0.6 -0.8 -0.9 -0.7 1.2 -0.2 -1.0 -0.8
Supplements: Fish oil (including cod liver oil) 0.5 0.6 5.0 0.0 -0.3 -0.2 -0.1 -0.0 0.2 -0.3 -0.2 1.1 2.2 0.1
High cholesterol (Self-reported) 0.5 1.0 2.4 -1.2 -1.3 0.9 -0.7 -1.1 0.5 -0.6 -0.2 0.7 1.5 -1.0
Medication: Bendroflumethiazide 0.6 0.8 2.2 0.8 0.3 -1.2 -0.8 1.0 0.3 0.4 -1.5 -1.2 0.8 1.0
Medication: Paracetamol 0.7 1.2 2.1 1.2 1.2 -1.4 -0.6 1.1 -0.4 1.0 0.3 -1.3 -1.2 1.2
Medication: Lisinopril 0.3 0.4 1.5 0.7 0.8 -0.6 -0.2 0.4 -0.0 0.2 0.6 -1.2 -0.6 0.6
Medication: Atorvastatin 0.2 0.3 1.2 -0.1 0.3 -1.1 -0.2 0.2 0.7 0.5 0.6 -0.9 -0.3 0.2
Illnesses of father: High blood pressure 2.0 2.5 6.8 -1.8 -2.0 2.6 0.4 -1.9 -1.5 -1.5 -0.4 0.6 -0.9 -1.9
Alcohol drinker status: Never 0.5 0.6 2.2 0.8 0.9 0.1 0.2 0.7 -0.2 0.8 0.6 -1.5 -0.6 0.9
Ever smoked 0.7 1.2 6.2 -0.6 -0.5 1.0 2.5 -0.9 -1.0 -1.3 -0.1 -0.2 -0.3 -1.1
Basal metabolic rate 0.4 2.1 8.2 0.9 0.9 2.0 0.3 1.1 0.7 0.4 2.9 -1.2 -2.5 0.5
Leg fat percentage (left) 0.2 0.7 3.0 -1.0 -0.3 0.2 -0.9 -0.1 0.8 0.9 1.7 -1.3 0.3 -0.1
Arm fat-free mass (left) 0.3 1.7 6.0 0.6 0.8 1.8 0.2 0.9 0.6 0.3 2.4 -1.2 -2.4 0.3
Number of operations (self-reported) 0.5 0.7 1.5 -0.5 -0.5 -0.1 -0.3 -1.0 -1.2 -1.2 0.3 1.0 -1.0 -0.9
Average weekly beer plus cider intake 0.3 0.4 2.4 -0.3 -0.2 -0.1 1.5 0.4 0.8 0.9 0.1 0.1 0.7 0.4
Irritability 0.4 0.7 2.1 -0.4 -0.4 0.2 -0.9 -1.2 -0.9 -1.4 0.3 -0.1 0.5 -1.1
Risk taking 0.6 0.9 3.6 -0.6 -0.4 0.9 1.6 -0.7 -1.0 -0.6 -0.1 0.5 -1.9 -0.8
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.8 1.2 1.1 -1.6 0.2 0.7 -0.9 0.2 -0.6 -1.7 -0.8 0.8
Fractured/broken bones in last 5 years 1.3 1.7 3.7 -1.9 -1.8 0.3 1.3 -1.3 -0.8 -0.6 0.6 -0.9 -1.9 -1.6
Age started oral contraceptive pill 0.3 0.3 1.3 0.1 0.1 0.9 -0.3 -0.1 0.4 -0.5 0.9 -0.6 1.1 0.1
Diastolic blood pressure, automated reading 0.1 0.3 1.7 0.0 0.2 0.4 0.1 0.6 -0.7 0.8 0.1 0.4 -1.3 0.4
Ever depressed for a whole week 1.0 1.3 2.5 -1.1 -1.2 -0.2 0.6 -1.5 -0.1 -1.6 0.9 1.2 1.2 -1.5
Unable to work because of sickness or disability 1.2 1.6 6.3 0.0 -0.1 -1.1 1.3 0.4 2.5 0.2 1.0 0.4 2.5 0.3
Commuting to job workplace: Cycle 0.3 0.3 1.6 -0.1 -0.3 0.8 1.3 -0.2 -0.3 -0.5 -0.1 -0.8 -0.2 -0.3
Myopia 0.6 0.8 2.7 0.6 1.2 -1.1 -0.3 0.9 1.6 1.0 -0.5 -0.7 0.5 0.8
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.8 0.4 1.0 -0.2 -0.5 0.8 0.2 1.7 1.3 0.7 -1.4 0.7
Cholesterol lowering medication 0.6 0.9 4.7 1.0 1.0 -1.6 -2.2 0.4 0.2 0.3 -0.0 0.2 0.3 0.7
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.9 -1.0 -1.3 -0.0 1.3 -1.2 -0.8 -1.4 0.2 -1.0 -0.2 -1.2
Pain experienced in last month 0.6 0.9 6.8 -0.6 -0.3 0.8 -0.4 -0.1 0.3 1.0 -2.6 0.1 1.0 -0.0
Supplements: Calcium 0.8 0.9 2.0 -0.6 -0.8 1.0 -1.2 -1.0 0.0 -1.2 -1.4 0.1 1.0 -0.9
Basal cell carcinoma (self-reported) 0.3 0.3 0.9 -0.7 -0.5 0.2 -0.0 -0.7 -0.6 0.0 0.9 0.9 0.1 -0.5
Heart attack/myocardial infarction (self-reported) 2.0 2.5 6.0 -1.3 -1.7 1.2 0.1 -1.9 -0.7 -2.2 -0.6 2.4 1.7 -2.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.6 -0.8 -1.2 0.1 0.4 -0.8 -0.5 -1.3 0.4 -0.5 1.1 -0.8
Heart disease (siblings) 0.8 1.0 4.9 -0.2 0.1 0.6 -0.5 0.4 2.2 0.8 1.7 -0.2 1.4 0.3
Alcohol drinker status: Previous 1.6 1.8 4.3 -2.1 -1.9 2.1 1.4 -0.8 1.2 0.7 -0.7 0.5 1.4 -0.8
Pack years of smoking 0.2 0.3 1.1 -1.0 -0.5 0.2 0.0 -0.0 1.0 0.7 0.4 -0.2 -0.5 -0.1
Impedance of whole body 1.0 5.2 12.6 -1.8 -2.2 -0.9 -1.4 -2.9 -2.3 -2.9 -3.6 2.2 1.1 -2.4
Leg fat mass (left) 0.2 0.9 4.9 -0.7 -0.1 0.9 -0.5 0.1 0.9 0.7 2.2 -1.3 -0.4 -0.1
Arm predicted mass (left) 0.3 1.7 7.2 0.6 0.6 2.0 0.2 0.8 0.5 0.2 2.7 -1.1 -2.1 0.3