TWAS hub - DYSFIP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0350	0.0330	0.0022	0.020	0.018	0.001	NA	0.016	0.00750	0.0100	0.2600	NA	0.0160
2	TCGA	Colon Adenocarcinoma	0.0890	0.1350	0.0022	0.034	0.028	0.042	NA	0.030	0.00440	0.0090	0.0018	NA	0.0071
3	TCGA	Lung Squamous Cell Carcinoma	0.0275	0.0279	0.0014	0.023	0.025	0.023	NA	0.023	0.00096	0.0007	0.0011	NA	0.0011
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0400	0.0460	0.0081	0.021	0.019	0.022	NA	0.019	0.01300	0.0170	0.0120	NA	0.0180

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Had other major operations	9.7	11.8	13.5	-3.7	2.8	-3.7	3.5
Exposure to tobacco smoke outside home	7.2	9.6	10.0	-3.1	3.0	-3.1	3.2
Smoking status: Current	6.6	10.5	11.1	3.3	-3.3	3.2	-3.1
Current tobacco smoking	5.9	9.7	10.1	3.2	-3.0	3.2	-3.1
Multivitamins +/- minerals	4.8	6.0	6.3	-2.5	2.5	-2.5	2.4
Number of operations (self-reported)	4.4	6.6	8.1	-2.8	1.6	-2.9	2.8
Illnesses of father: None of the above (group 1)	4.0	5.0	5.7	-2.1	2.4	-2.1	2.4
Vitamin and mineral supplements	3.9	5.3	5.7	2.4	-2.1	2.4	-2.3
Chronic bronchitis/emphysema (mother)	3.8	4.5	4.8	-2.1	2.0	-2.1	2.2
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	5.5	-2.1	2.4	-2.1	2.2
Mineral and other dietary supplements	3.7	4.9	5.7	2.4	-1.9	2.4	-2.2
Blood Red Count	3.6	34.8	37.1	-6.1	5.4	-6.1	6.1
Mouth/teeth dental problems	3.5	5.4	6.4	2.3	-2.0	2.4	-2.5
Falls in the last year	3.3	4.5	5.7	2.1	-1.8	2.2	-2.4
Alcohol usually taken with meals	3.2	5.1	6.6	-2.5	1.2	-2.6	2.4
Worrier / anxious feelings	3.2	6.1	7.4	-2.6	1.9	-2.6	2.7
Supplements: Calcium	3.2	3.6	4.4	-2.1	1.4	-2.1	1.9
Alcohol intake versus 10 years previously	3.1	4.6	5.2	-2.3	1.9	-2.3	2.1
Mouth/teeth dental problems: Bleeding gums	2.9	3.8	4.0	-1.9	1.9	-1.9	2.0
Medication for hormone replacement therapy	2.8	3.1	3.3	-1.8	1.6	-1.8	1.8
Pulse wave reflection index	2.8	3.4	4.1	2.0	-1.5	2.0	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	3.9	2.0	-1.2	2.0	-1.9
Average weekly red wine intake	2.7	4.0	4.6	-2.2	1.7	-2.1	1.9
Medication: Aspirin	2.7	3.5	3.6	-1.9	1.8	-1.9	1.9
Medication: Seretide 50 evohaler	2.5	2.9	3.5	1.7	-1.9	1.7	-1.5
Rheumatoid Arthritis	2.4	3.3	3.8	-2.0	1.5	-1.9	1.9
Chronic bronchitis/emphysema (father)	2.4	2.8	4.4	1.5	-2.1	1.5	-1.6
Basal cell carcinoma (self-reported)	2.4	2.9	3.6	-1.9	0.9	-1.9	1.9
Gout (self-reported)	2.3	3.1	3.4	-1.7	1.9	-1.7	1.8
Smoking Status	2.2	5.3	5.8	2.3	-2.4	2.3	-2.3
Medication: Co-codamol	2.2	2.6	2.9	1.7	-1.3	1.7	-1.7
Osteoporosis (self-reported)	2.2	2.7	3.1	-1.6	1.8	-1.6	1.5
Irritability	2.2	3.7	4.1	-2.0	1.7	-2.0	1.9
Ovarian Cancer	2.1	2.8	3.1	1.8	-1.7	1.7	-1.5
Medication: Lansoprazole	2.1	2.4	3.0	1.7	-1.1	1.7	-1.6
Medication: Aspirin	2.1	2.7	2.9	-1.7	1.6	-1.7	1.7
Ever had bowel cancer screening	2.1	2.5	3.4	-1.7	0.9	-1.7	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	3.3	-1.8	1.6	-1.8	1.8
Miserableness	1.9	3.4	4.0	-2.0	1.3	-2.0	2.0
Alcohol drinker status: Never	1.8	2.2	2.6	1.6	-1.1	1.6	-1.6
Headache pain in last month	1.7	2.9	3.3	-1.7	1.6	-1.7	1.8
High blood pressure (siblings)	1.7	2.4	2.9	-1.7	1.0	-1.7	1.7
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.2	-1.5	1.2	-1.5	1.5
Risk taking	1.7	2.5	2.9	1.6	-1.5	1.6	-1.7
Alzheimer’s Disease (in father)	1.6	1.8	2.3	1.4	-0.8	1.5	-1.5
Medication: Allopurinol	1.6	2.2	2.4	-1.5	1.2	-1.6	1.6
Myopia	1.6	2.3	2.5	-1.6	1.4	-1.6	1.6
Shortness of breath walking on level ground	1.4	1.6	2.0	1.2	-1.4	1.2	-1.3
Mood swings	1.4	2.5	3.3	-1.8	0.8	-1.8	1.7
Depressed Affect (Nagel 2018)	1.3	2.7	3.1	-1.8	1.3	-1.8	1.6
Ulcerative Colitis	1.3	1.8	2.3	-1.5	0.8	-1.5	1.4
Angina (self-reported)	1.3	1.7	1.8	-1.2	1.3	-1.2	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.4	0.8	-1.9	0.7	-0.9
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.2	-1.3	1.5	-1.3	1.1
Alzheimer’s Disease (including proxy)	1.2	1.7	2.0	1.4	-1.1	1.4	-1.4
Prostate Cancer	1.2	1.7	3.2	1.1	-1.8	1.1	-1.2
Relative age of first facial hair	1.2	2.4	3.3	1.8	-0.7	1.8	-1.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.7	-1.3	0.4	-1.3	1.3
Lung cancer (father)	1.2	1.3	1.6	-1.1	1.3	-1.1	1.1
Neuroticism (Nagel 2018)	1.1	2.5	3.4	-1.8	0.7	-1.8	1.7
Mean Putamen Volume	1.1	1.2	1.7	1.0	-1.3	1.0	-1.1
Hearing difficulty/problems: Yes	1.1	1.7	2.0	-1.4	1.0	-1.4	1.4
Hair/balding pattern: Pattern 4	1.1	2.7	2.9	-1.7	1.6	-1.7	1.5
Illnesses of father: Heart disease	1.1	1.6	2.0	1.3	-1.1	1.3	-1.4
Ever smoked	1.1	1.9	2.6	1.3	-1.6	1.3	-1.3
Lupus	1.0	1.5	1.9	-1.2	1.1	-1.2	1.4
Systolic blood pressure, automated reading	1.0	3.0	5.2	-1.5	2.3	-1.5	1.6
Angina	1.0	1.3	1.4	-1.1	1.2	-1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	2.6	1.4	-1.6	1.4	-1.6
Neuroticism score	1.0	2.2	2.4	-1.6	1.2	-1.6	1.5
Birth weight of first child	1.0	1.9	2.6	-1.5	0.4	-1.6	1.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	1.5	1.2	-1.1	1.2	-1.1
Worry (Nagel 2018)	0.9	2.0	2.6	-1.6	0.6	-1.6	1.6
Hair Pigment	0.9	25.6	29.1	5.4	-4.1	5.4	-5.3
Average weekly fortified wine intake	0.9	1.0	1.1	-1.0	1.1	-1.0	1.0
Nervous feelings	0.9	1.7	1.9	-1.4	1.1	-1.4	1.3
Mother’s age at death	0.9	1.1	2.3	-0.8	1.5	-0.8	0.9
Medication: Atorvastatin	0.9	1.1	1.3	-1.1	0.8	-1.1	1.1
Ulcerative Colitis (UC)	0.8	1.6	1.7	-1.3	1.3	-1.2	1.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.0	1.0	-0.8	1.0	-0.9
Heart attack	0.8	1.1	1.3	1.2	-0.7	1.2	-1.1
Leg fat percentage (right)	0.8	2.8	3.2	-1.8	1.4	-1.8	1.7
Long-standing illness, disability or infirmity	0.8	1.2	1.5	1.2	-0.8	1.2	-1.1
Bipolar Disorder (2018)	0.7	1.1	1.3	1.1	-0.8	1.1	-1.2
Cardiovascular Disease	0.7	2.4	2.7	1.6	-1.3	1.6	-1.6
Average weekly spirits intake	0.7	0.9	1.3	0.9	-1.1	0.8	-0.8
Fluid intelligence score	0.7	1.5	1.7	-1.2	1.1	-1.2	1.3
Body fat percentage	0.7	2.9	3.3	-1.8	1.4	-1.8	1.8
Neck or shoulder pain in last month	0.7	1.0	1.3	-1.1	0.4	-1.2	1.1
Whole body fat mass	0.7	2.9	3.3	-1.8	1.3	-1.8	1.8
Leg fat mass (right)	0.7	2.8	3.2	-1.8	1.4	-1.8	1.8
Leg fat percentage (left)	0.7	2.4	2.7	-1.7	1.3	-1.7	1.6
Leg fat mass (left)	0.7	2.7	3.0	-1.7	1.3	-1.7	1.7
Blood White Count	0.6	4.5	5.7	2.4	-1.4	2.4	-2.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.6	-0.9	1.1	-0.9	1.2
Neuroticism	0.6	1.4	1.7	-1.3	0.9	-1.3	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	-1.0	0.3	-1.0	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	1.1	-0.9	1.1	-1.4
Medication: Atenolol	0.6	0.8	0.8	-0.9	0.9	-0.9	0.8
Trunk fat mass	0.6	2.7	3.1	-1.7	1.3	-1.7	1.8
Birth weight	0.6	1.3	1.8	-1.3	0.5	-1.3	1.2
Had major operations	0.6	0.7	1.9	0.6	-1.4	0.6	-0.6
Supplements: Vitamin C	0.6	0.7	1.0	-0.8	1.0	-0.8	0.8
Arm fat percentage (left)	0.6	2.5	2.6	-1.6	1.5	-1.6	1.6
Average weekly beer plus cider intake	0.6	0.8	1.0	1.0	-0.8	1.0	-0.9
Fractured/broken bones in last 5 years	0.6	0.8	1.0	-1.0	0.4	-1.0	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.0	1.0	-0.4	1.0	-0.9
Blood Platelet Count	0.5	5.5	6.6	2.4	-2.0	2.4	-2.6
Severe depression (siblings)	0.5	0.5	0.7	-0.8	-0.1	-0.9	0.8
Trunk fat percentage	0.5	2.2	2.5	-1.6	1.2	-1.6	1.6
High blood pressure	0.5	1.3	1.7	1.3	-0.7	1.3	-1.2
Stomach or abdominal pain in last month	0.5	0.6	1.2	-0.6	1.1	-0.6	0.7
High blood pressure (mother)	0.5	0.7	1.0	0.8	-0.7	0.8	-1.0
Arm fat percentage (right)	0.5	1.9	1.9	-1.4	1.4	-1.4	1.4
Happiness	0.5	0.6	1.0	-1.0	-0.1	-1.0	0.8
Medication: Ibuprofen	0.5	0.6	0.7	-0.8	0.8	-0.8	0.8
Medication: Omeprazole	0.5	0.6	0.9	-0.8	0.2	-0.9	1.0
Arm fat mass (left)	0.5	2.1	2.2	-1.5	1.3	-1.5	1.5
Eye problems/disorders: Glaucoma	0.5	0.6	0.7	0.9	-0.6	0.9	-0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	-0.9	0.5	-0.9	0.7
Commuting to job workplace: Cycle	0.5	0.6	0.8	0.9	0.1	0.9	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	1.7	-1.3	0.6	-1.3	1.3
Pain experienced in last month	0.5	0.8	1.1	0.9	-0.7	0.9	-1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.1	1.1	-1.0	1.0	-0.8
Crohns Disease (2017)	0.4	0.8	1.0	0.9	-0.7	0.9	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.1	-0.9	0.9	-1.0	1.1
Allergy or Eczema	0.4	0.9	1.1	-1.0	0.7	-1.0	1.1
Hand grip strength (left)	0.4	1.0	1.2	-1.1	0.7	-1.1	1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.8	-0.8	0.0	-0.9	0.9
Medication: Metformin	0.4	0.5	1.3	0.6	-1.1	0.5	-0.4
Waist circumference	0.4	1.5	1.8	-1.3	1.0	-1.3	1.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.8	0.3	-0.8	1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.6	-1.1	0.6	-0.8
Prospective memory result	0.4	0.5	1.1	-0.6	1.0	-0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.4	-1.1	0.9	-1.1	1.2
Arm fat mass (right)	0.4	1.8	1.9	-1.4	1.2	-1.4	1.4
Length of working week for main job	0.4	0.4	0.6	0.7	-0.4	0.7	-0.8
Breastfed as a baby	0.4	0.5	0.7	-0.8	0.7	-0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	-0.4	1.0	-0.4	0.6
Age at first live birth	0.4	0.7	0.9	0.8	-0.7	0.9	-1.0
Health satisfaction	0.4	0.5	0.7	-0.8	0.5	-0.8	0.8
Alcohol intake frequency.	0.4	1.0	1.2	1.0	-1.1	1.0	-0.9
Suffer from ‘nerves’	0.4	0.7	0.9	-0.9	0.2	-1.0	0.9
Average weekly champagne plus white wine intake	0.4	0.6	0.7	-0.8	0.5	-0.8	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	-0.7	0.3	-0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	0.8	-0.5	0.8	-0.7
Alcohol drinker status: Previous	0.4	0.5	1.7	0.3	-1.3	0.2	-0.1
Depression (Nagel 2018)	0.3	0.5	0.7	-0.8	0.5	-0.8	0.7
Schizophrenia (2014)	0.3	0.8	1.1	1.0	-0.7	1.0	-0.7
Blood Eosinophil Count	0.3	2.6	3.3	1.8	-1.1	1.8	-1.5
Heel T-Score	0.3	2.2	2.4	1.4	-1.6	1.4	-1.5
Chronotype (morning person)	0.3	0.7	0.8	0.9	-0.8	0.9	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.5	0.6	-0.7	0.6	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	-0.7	0.5	-0.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.4	0.8	-0.4	0.5
Serious illness, injury or assault to yourself	0.3	0.3	0.4	-0.7	0.3	-0.7	0.6
Body mass index (BMI)	0.3	1.5	1.7	-1.2	1.1	-1.2	1.3
Past tobacco smoking	0.3	0.6	1.3	-0.6	1.2	-0.6	0.6
Had menopause	0.3	0.4	0.6	-0.6	0.3	-0.7	0.8
Medication: Ramipril	0.3	0.3	0.4	0.6	-0.3	0.6	-0.6
Weight	0.3	1.7	2.0	-1.4	0.9	-1.4	1.4
Hip circumference	0.3	1.4	1.7	-1.3	0.8	-1.3	1.2
Father’s age at death	0.3	0.4	0.6	-0.8	0.2	-0.8	0.6
Number of live births	0.3	0.4	0.5	-0.6	0.2	-0.7	0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.7	0.3	-0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.6	0.6	-0.8	0.6	-0.6
Forced vital capacity (FVC), Best measure	0.3	0.9	1.1	-0.9	0.9	-1.0	1.1
Wheeze or whistling in the chest in last year	0.3	0.4	0.6	0.6	-0.8	0.6	-0.7
Age at last live birth	0.3	0.5	0.7	0.6	-0.7	0.6	-0.8
Smoking status: Previous	0.3	0.4	0.6	-0.8	0.3	-0.8	0.7
Medication for cholesterol	0.3	0.5	0.6	0.7	-0.4	0.8	-0.7
Breast cancer (self-reported)	0.3	0.4	0.6	-0.8	0.0	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.9	1.0	-0.2	1.0	-0.8
Wears glasses or contact lenses	0.3	0.3	0.5	-0.6	0.7	-0.5	0.4
High cholesterol (Self-reported)	0.3	0.6	0.7	0.9	-0.6	0.9	-0.8
BMI	0.2	1.2	1.4	-1.2	1.0	-1.2	1.1
Height	0.2	3.5	4.5	-2.1	0.9	-2.1	2.1
Hypothyroidism (self reported)	0.2	0.5	0.6	0.8	-0.6	0.8	-0.7
Tanning	0.2	2.8	3.2	-1.8	1.5	-1.8	1.6
Number of treatments/medications taken	0.2	0.4	0.6	-0.5	0.7	-0.5	0.6
Sensitivity / hurt feelings	0.2	0.4	0.5	-0.7	-0.0	-0.7	0.7
Supplements: Zinc	0.2	0.3	0.5	-0.4	0.7	-0.4	0.5
Diabetes (father)	0.2	0.2	0.4	-0.4	0.6	-0.4	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	0.4	-0.7	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.5	-0.5	0.5	-0.5
Medication: Levothyroxine sodium	0.2	0.3	0.4	-0.6	0.4	-0.6	0.6
Pain all over the body in last month	0.2	0.3	0.4	0.6	-0.4	0.6	-0.5
Illnesses of siblings	0.2	0.3	0.3	0.6	0.2	0.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.8	-0.9	0.6	-0.9	0.9
Pulse rate	0.2	0.4	0.5	-0.6	0.6	-0.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.5	-0.2	0.5	-0.4
Asthma	0.2	0.5	0.7	0.8	-0.2	0.8	-0.7
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.4	0.3	-0.4	0.5
Blood clot in the leg (DVT)	0.2	0.2	0.3	0.6	-0.4	0.6	-0.5
Comparative body size at age 10	0.2	0.5	1.9	0.2	-1.4	0.2	-0.3
Eye problems/disorders: None of the above	0.2	0.3	0.4	0.6	-0.4	0.6	-0.6
Medication: Blood pressure	0.2	0.4	0.4	0.6	-0.6	0.6	-0.7
Heart disease (mother)	0.2	0.2	0.3	0.5	-0.6	0.5	-0.2
Pulse rate, automated reading	0.2	0.5	0.6	0.8	-0.7	0.8	-0.7
Chest pain or discomfort	0.2	0.3	0.4	-0.6	0.3	-0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.5	-0.4	-0.6	0.5
Hypertension (Self-reported)	0.2	0.5	0.6	0.8	-0.3	0.8	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.2	-0.5	0.2	-0.5	0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.8	0.1	-0.9	0.1	-0.1
Commuting to job workplace: Walk	0.2	0.2	0.3	0.5	0.1	0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.5	-0.6	0.7	-0.6	0.7
Asthma (self-reported)	0.2	0.5	0.7	0.8	-0.2	0.8	-0.8
Osteoarthritis (self-reported)	0.2	0.3	0.3	-0.6	0.5	-0.6	0.6
Medication: Gliclazide	0.2	0.2	0.3	-0.5	0.1	-0.5	0.6
Ever taken oral contraceptive pill	0.2	0.3	1.0	0.2	-1.0	0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	0.5	0.3	0.5	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.2	0.5	-0.4	0.5	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.5	0.4	-0.7	0.4	-0.3
Pack years of smoking	0.2	0.3	0.6	-0.4	0.6	-0.5	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.3	0.7	-0.3	0.3
Schizophrenia (2018)	0.1	0.1	0.2	0.4	-0.5	0.4	-0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.3	-0.2	0.3	-0.2
Respiratory disease	0.1	0.3	0.5	0.7	-0.0	0.7	-0.5
Diabetes (mother)	0.1	0.1	0.4	-0.0	-0.6	-0.0	-0.1
Pack years adult smoking proportion	0.1	0.1	0.2	-0.2	0.3	-0.2	0.5
Maternal smoking around birth	0.1	0.2	0.5	0.3	-0.7	0.3	-0.4
Fed-up feelings	0.1	0.3	0.9	-0.2	0.9	-0.2	0.3
Relative age voice broke	0.1	0.1	0.2	-0.2	0.4	-0.2	0.2
Taking other prescription medications	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.3	0.0	0.3	-0.3
Supplements: Glucosamine	0.1	0.1	0.1	-0.3	0.2	-0.3	0.3
Sitting height	0.1	0.9	2.0	0.7	-1.4	0.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.0	-0.6	-0.0	-0.0
Forced vital capacity (FVC)	0.1	0.3	0.4	-0.6	0.5	-0.6	0.6
Qualifications: None of the above	0.1	0.2	0.2	0.5	-0.0	0.5	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.1	0.2	0.4	0.3	-0.3
Medication: Cholesterol lowering	0.1	0.2	0.2	-0.4	0.4	-0.4	0.4
Depression (self-reported)	0.1	0.1	0.2	0.3	-0.4	0.3	-0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	0.4	-0.2	0.3	-0.1
Tense / ‘highly strung’	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.6	0.1	-0.7	0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	0.0	-0.4	0.5
Loud music exposure frequency	0.1	0.1	0.4	0.3	-0.6	0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.1	-0.3	0.1	-0.3	0.3
Medication: Amlodipine	0.1	0.1	0.2	0.4	-0.3	0.4	-0.2
Arm fat-free mass (right)	0.1	0.5	0.7	-0.7	0.4	-0.8	0.8
Worry too long after embarrassment	0.1	0.2	0.2	-0.5	-0.1	-0.5	0.4
Number of children fathered	0.1	0.1	0.1	-0.3	0.0	-0.3	0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	0.2	-0.4	0.2
Qualifications: College or University degree	0.1	0.3	0.4	-0.6	0.0	-0.6	0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4
Mean time to correctly identify matches	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.3	0.2	-0.3	0.5
Arm predicted mass (right)	0.1	0.8	1.0	-0.9	0.5	-1.0	1.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.3	-0.6	0.3	-0.4
Knee pain experienced in last month	0.1	0.2	0.5	-0.3	0.7	-0.3	0.2
Loneliness, isolation	0.1	0.1	0.3	0.0	0.6	0.0	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.4	-0.1	-0.5	0.6
Friendships satisfaction	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.3
Qualifications: nursing, teaching	0.1	0.2	0.3	0.3	-0.3	0.4	-0.5
Guilty feelings	0.1	0.1	0.3	-0.0	-0.6	-0.0	-0.1
Hearing aid user	0.1	0.1	0.2	-0.4	0.2	-0.4	0.3
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.5
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.2	-0.3	0.3	-0.4
Basal metabolic rate	0.1	0.3	0.4	-0.6	0.3	-0.6	0.6
Age started oral contraceptive pill	0.1	0.1	0.2	-0.4	0.3	-0.4	0.3
Diastolic blood pressure, automated reading	0.1	0.5	1.1	-0.4	1.0	-0.4	0.6
Ever depressed for a whole week	0.1	0.1	0.4	0.2	-0.6	0.2	-0.2
Cholesterol lowering medication	0.1	0.1	0.1	0.4	-0.2	0.4	-0.4
Heart disease (siblings)	0.1	0.2	0.3	-0.5	-0.1	-0.5	0.5
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.4	0.4	-0.3	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.0	0.0	0.0	0.0	-0.1	0.0	0.1
Breast Cancer	0.0	0.1	0.2	-0.3	-0.4	-0.3	0.0
Age at First Birth	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.1	-0.0	0.1	0.0	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.3	0.3	-0.3	0.3
Systolic Blood Pressure	0.0	0.2	0.4	0.6	0.0	0.6	-0.4
Lung FEV1/FVC ratio	0.0	0.1	0.2	-0.5	0.2	-0.4	0.2
Lung FVC	0.0	0.1	0.3	0.1	-0.5	0.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.1	0.1	0.1	-0.0
Impedance of leg (right)	0.0	0.2	0.3	0.3	-0.6	0.3	-0.5
Leg fat-free mass (left)	0.0	0.2	0.4	-0.5	0.2	-0.5	0.6
Hand grip strength (right)	0.0	0.0	0.1	0.1	-0.3	0.1	-0.0
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.3	-0.0	0.3	-0.1
Age when periods started (menarche)	0.0	0.1	0.1	-0.3	-0.2	-0.3	0.3
Impedance of leg (left)	0.0	0.2	0.3	0.2	-0.5	0.3	-0.5
Leg predicted mass (left)	0.0	0.2	0.3	-0.4	0.2	-0.5	0.6
Number of incorrect matches in round	0.0	0.0	0.0	-0.1	0.2	-0.1	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.3	0.2	0.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.2	-0.0	-0.4	-0.0	0.0
Allergy	0.0	0.1	0.1	0.3	-0.1	0.3	-0.3
Diabetes (self-reported)	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.3
Medication: Simvastatin	0.0	0.0	0.0	0.1	0.2	0.1	-0.1
Impedance of arm (right)	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2
Trunk fat-free mass	0.0	0.2	0.2	-0.4	0.3	-0.4	0.5
Time employed in main current job	0.0	0.1	0.1	-0.2	-0.1	-0.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.0	-0.0	0.0	0.1
Noisy workplace	0.0	0.1	0.1	-0.2	-0.2	-0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.2	0.0	0.2	-0.2
Illnesses of mother	0.0	0.0	0.0	0.0	-0.1	0.0	-0.2
Impedance of arm (left)	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.1
Trunk predicted mass	0.0	0.2	0.2	-0.4	0.2	-0.4	0.5
Standing height	0.0	0.1	0.2	-0.4	-0.4	-0.4	0.3
Medication: Paracetamol	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2
Glaucoma (self-reported)	0.0	0.0	0.0	0.2	-0.1	0.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.0	-0.2	-0.0	0.1
Number of full brothers	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.1	-0.3	0.1	0.0
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.2	-0.3	0.2	-0.0
Migraine (self-reported)	0.0	0.0	0.1	-0.0	0.3	0.0	0.0
Comparative height size at age 10	0.0	0.0	0.1	0.1	-0.3	0.1	-0.0
Number of full sisters	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Overall health rating	0.0	0.1	0.1	-0.4	-0.0	-0.4	0.4
Family relationship satisfaction	0.0	0.0	0.0	-0.2	0.1	-0.2	0.1
Leg pain on walking	0.0	0.0	0.1	-0.1	0.1	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	-0.0	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	0.0	-0.2	-0.0	0.2
Whole body fat-free mass	0.0	0.2	0.3	-0.5	0.3	-0.5	0.6
Leg fat-free mass (right)	0.0	0.1	0.2	-0.3	0.1	-0.4	0.5
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.0	0.1	0.1	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1
Back pain experienced in last month	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.3
Whole body water mass	0.0	0.2	0.3	-0.4	0.2	-0.4	0.5
Leg predicted mass (right)	0.0	0.1	0.2	-0.3	0.1	-0.3	0.4
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	0.3	0.1	0.3	-0.3
Financial situation satisfaction	0.0	0.0	0.0	0.0	-0.1	0.0	-0.0
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.0
Medication: Blood pressure	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0
Medication: Lisinopril	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2
Arm fat-free mass (left)	0.0	0.1	0.2	-0.4	0.1	-0.4	0.5
Impedance of whole body	0.0	0.1	0.1	0.1	-0.4	0.1	-0.3
Arm predicted mass (left)	0.0	0.2	0.3	-0.4	0.0	-0.4	0.5

Hub : Genes

DYSFIP1

Models

Trait associations