Best TWAS P=2.69e-12 · Best GWAS P=1.47e-13 conditioned to 1.33e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -5.3 | 5.7 | 1.0e-08 | -0.04 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | GMEB2 | 0.18 | 0.02 | lasso | 5 | 0.06 | 3.0e-04 | -5.7 | -5.9 | 3.3e-09 | -0.05 | 0.11 | 0.36 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | PCMTD2 | 0.29 | 0.01 | enet | 42 | 0.07 | 7.4e-05 | 4.1 | 5.2 | 2.0e-07 | 0.12 | 0.03 | 0.42 | TRUE |
| 4 | YFS | Blood | LIME1 | 0.12 | 0.19 | enet | 15 | 0.19 | 5.3e-59 | -5.6 | -5.9 | 3.4e-09 | 0.01 | 0.99 | 0.01 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | C20orf135 | 0.07 | 0.00 | blup | 28 | 0.06 | 3.9e-04 | -3.8 | 5.4 | 8.1e-08 | 0.31 | 0.04 | 0.20 | TRUE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TNFRSF6B | 0.03 | 0.01 | blup | 44 | 0.02 | 7.1e-04 | -5.7 | -6.1 | 1.1e-09 | -0.03 | 0.20 | 0.32 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -5.4 | -7.0 | 2.7e-12 | -0.08 | 0.07 | 0.16 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZGPAT | 0.05 | 0.04 | blup | 60 | 0.05 | 7.2e-07 | -5.7 | 5.3 | 8.8e-08 | 0.02 | 0.42 | 0.54 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | -5.7 | -5.9 | 3.3e-09 | 0.04 | 0.12 | 0.16 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RTEL1 | 0.05 | 0.04 | blup | 56 | 0.03 | 4.2e-03 | -4.2 | -6.7 | 1.9e-11 | 0.02 | 0.05 | 0.07 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | -5.3 | 5.3 | 1.2e-07 | -0.03 | 0.19 | 0.16 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -5.7 | -5.8 | 5.4e-09 | 0.04 | 0.51 | 0.46 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZGPAT | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.5e-07 | -5.6 | 5.8 | 7.6e-09 | -0.02 | 0.45 | 0.55 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | LIME1 | 0.05 | 0.03 | blup | 47 | 0.04 | 3.9e-05 | -5.7 | -5.6 | 1.8e-08 | 0.08 | 0.39 | 0.50 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | ZGPAT | 0.05 | 0.04 | blup | 60 | 0.03 | 2.3e-04 | -5.7 | 5.1 | 3.0e-07 | 0.02 | 0.41 | 0.52 | FALSE |