TWAS hub - GMEB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1890	0.0750	2.5e-03	0.013	NA	0.015	NA	0.013	0.06800	NA	5.2e-02	NA	0.06900
2	GTEx	Breast Mammary Tissue	0.1770	0.0610	2.6e-03	0.025	NA	0.060	NA	0.065	0.01900	NA	4.8e-04	NA	0.00030
3	GTEx	Breast Mammary Tissue (Female)	0.3569	0.1139	3.0e-03	0.055	NA	0.026	NA	0.052	0.00970	NA	5.8e-02	NA	0.01200
4	GTEx	Esophagus Muscularis	0.1090	0.0440	4.6e-03	0.021	NA	-0.002	NA	-0.002	0.01900	NA	4.5e-01	NA	0.47000
5	YFS	Blood	0.0385	0.0112	2.7e-06	0.010	0.017	0.011	0.017	0.014	0.00026	2.6e-06	9.6e-05	1.5e-06	0.00002
6	TCGA	Esophageal Carcinoma	0.1640	0.0710	2.3e-03	0.039	0.051	0.002	NA	0.021	0.02200	1.0e-02	2.8e-01	NA	0.06800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Irritable Bowel Disease (IBD)	9.9	23.6	52.6	-3.9	-4.4	-7.2	-5.6	-1.2	4.6
Allergy or Eczema	8.0	21.1	42.8	-3.7	-4.8	-6.5	-4.9	-1.9	4.4
Crohns Disease (2017)	7.9	17.3	34.8	-2.0	-3.3	-5.9	-5.3	-0.8	5.0
Allergy	7.9	18.1	35.3	5.0	4.2	5.9	3.6	0.4	-4.1
Diastolic blood pressure, automated reading	7.7	23.7	41.6	-4.3	-6.4	-5.7	-4.5	-5.0	1.8
Crohns Disease (2012)	7.5	12.0	29.2	-2.0	0.0	-5.4	-3.4	-0.1	5.2
Lung FVC	7.4	37.4	78.9	5.8	7.0	6.3	4.7	-1.0	-8.9
Wheeze or whistling in the chest in last year	7.3	12.9	26.1	-4.2	-4.2	-3.5	-1.8	-0.1	5.1
Hayfever, allergic rhinitis or eczema	7.2	15.6	34.2	-3.8	-3.5	-5.8	-4.2	-0.9	3.7
Current tobacco smoking	6.4	10.4	17.8	-3.9	-3.8	-4.2	-2.3	0.0	3.1
Medication: Blood pressure	6.3	11.9	25.6	-2.2	-5.1	-4.2	-4.0	-2.5	0.8
Smoking status: Current	6.1	9.7	15.8	-4.0	-3.6	-3.9	-2.3	-0.3	3.0
Ulcerative Colitis	5.9	8.5	24.2	-3.3	0.0	-4.9	-2.2	0.2	3.4
Asthma	5.9	11.7	23.2	-4.8	-3.2	-3.9	-1.4	0.7	4.4
Systolic blood pressure, automated reading	5.8	16.8	39.0	-3.1	-6.2	-5.6	-3.0	-2.7	2.2
Asthma (self-reported)	5.7	11.4	21.5	-4.6	-3.0	-3.8	-1.3	0.8	4.6
Respiratory disease	5.6	12.5	23.1	-4.1	-4.3	-3.8	-1.3	0.5	4.8
Number of self-reported non-cancer illnesses	5.6	9.7	19.0	-2.1	-4.4	-4.0	-3.0	-2.6	1.8
Ulcerative Colitis (UC)	5.4	10.2	24.3	-3.8	-3.0	-4.9	-3.1	-1.3	1.5
Forced vital capacity (FVC)	5.3	20.6	30.3	4.8	5.5	4.9	3.6	1.8	-5.5
Prostate Cancer	5.1	7.1	14.5	-2.0	-3.8	-3.7	-1.8	0.6	2.6
Pack years adult smoking proportion	5.1	7.7	18.0	-3.9	-1.8	-2.5	-4.2	-1.7	1.0
Pain all over the body in last month	5.1	5.5	9.4	-2.1	-3.1	-2.8	-2.3	-2.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.6	9.7	19.1	3.2	3.2	3.8	2.2	-0.4	-4.4
Leg fat percentage (left)	4.4	16.1	32.8	-4.7	-3.5	-3.8	-2.1	-3.2	5.7
Cardiovascular Disease	4.2	13.8	26.8	-2.6	-5.2	-4.4	-4.0	-3.5	1.3
Forced vital capacity (FVC), Best measure	4.2	15.4	27.1	3.8	4.3	4.4	3.3	1.5	-5.2
Vascular/heart problems diagnosed by doctor	4.2	11.5	28.3	1.6	5.3	4.0	3.6	3.0	-0.9
Pack years of smoking	4.2	6.2	15.5	-3.2	-1.6	-2.1	-3.9	-1.7	1.0
Systolic Blood Pressure	4.1	20.4	41.5	-2.2	-6.4	-5.9	-4.8	-4.2	0.7
High blood pressure	4.1	11.4	28.2	-1.9	-5.3	-3.8	-3.6	-2.9	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	4.0	6.2	9.4	-2.7	-2.7	-3.1	-2.8	-1.9	1.2
Hypertension (Self-reported)	3.9	10.8	27.3	-2.2	-5.2	-3.7	-3.4	-2.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	5.0	9.9	-3.1	-2.1	-2.7	-2.3	-1.2	1.2
Leg fat percentage (right)	3.7	13.5	27.1	-4.2	-3.4	-3.5	-1.7	-3.0	5.2
Qualifications: College or University degree	3.7	11.8	17.4	3.0	3.6	4.2	3.9	2.6	-3.1
Medication for cholesterol	3.7	5.6	13.8	1.2	3.7	3.2	2.7	0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	3.6	12.0	21.0	4.1	4.0	3.4	2.5	0.5	-4.6
Illnesses of siblings: Diabetes	3.5	4.3	13.0	-1.4	-1.6	-2.3	-1.2	1.3	3.6
Myopia	3.4	4.9	10.2	3.2	2.6	1.8	-0.2	3.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.4	22.8	3.9	3.1	3.2	2.1	0.2	-4.8
Medication for pain relief, constipation, heartburn	3.3	5.7	11.4	2.4	2.3	2.4	1.6	3.4	-1.8
Medication: Bendroflumethiazide	3.3	5.0	10.2	-2.1	-2.8	-2.4	-1.1	-3.2	-0.2
Type 2 Diabetes (T2D) (2018)	3.2	6.1	13.0	-2.8	-2.9	-3.6	-1.5	1.0	2.0
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	8.0	-2.8	-2.8	-2.2	-1.8	-0.6	0.6
Diabetes (father)	3.2	4.0	11.1	-3.3	-1.4	-2.3	-1.2	-0.9	1.8
Qualifications: CSEs or equivalent	3.2	4.2	10.4	-1.3	-1.6	-2.4	-3.2	-1.3	1.8
Chronic bronchitis/emphysema (mother)	3.2	3.8	9.0	-3.0	-2.1	-1.6	-1.0	1.7	1.6
Angina	3.0	3.9	7.5	-0.4	-2.6	-1.5	-2.7	-2.6	-0.6
Angina (self-reported)	3.0	4.0	8.5	-0.3	-2.5	-1.4	-2.9	-2.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	8.0	-2.6	-1.7	-1.1	-1.0	-1.3	2.8
Blood Platelet Count	2.8	31.9	55.7	-6.3	-6.9	-7.5	-4.1	-0.7	5.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	8.6	-1.9	-1.6	-2.9	-1.0	-0.7	1.8
Long-standing illness, disability or infirmity	2.8	4.3	12.2	-2.0	-3.5	-1.9	-1.9	0.1	1.5
Body fat percentage	2.7	10.9	28.5	-3.6	-2.5	-3.1	-1.9	-2.1	5.3
Illness, injury, bereavement, stress in last 2 years	2.6	3.1	4.5	1.9	2.1	2.0	1.7	-0.4	-1.9
Diabetes diagnosed by doctor	2.6	4.4	6.8	-2.6	-2.2	-2.4	-0.9	1.4	2.4
Medication: Atorvastatin	2.6	3.2	7.7	-0.6	-1.2	-0.8	-2.6	-2.8	-1.6
Ovarian Cancer	2.5	3.3	8.3	-0.7	-1.4	-2.9	-2.0	0.9	2.1
Smoking Status	2.5	6.0	12.6	-2.6	-2.8	-3.6	-1.1	0.1	2.7
Medication: Ventolin 100micrograms inhaler	2.5	3.2	7.1	-1.3	-1.9	-1.9	-0.0	1.6	2.7
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	7.1	-0.8	-2.7	-1.6	-1.5	-0.7	2.1
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	10.2	1.3	3.2	2.5	1.5	-0.6	-1.8
Breast cancer (self-reported)	2.5	2.9	5.6	2.3	1.4	1.7	1.4	2.4	0.1
Leg fat mass (left)	2.5	9.8	18.0	-3.9	-3.0	-3.0	-1.4	-2.3	4.2
Commuting to job workplace: Walk	2.4	2.5	4.0	-1.2	-1.5	-2.0	-2.0	1.3	1.4
Unable to work because of sickness or disability	2.4	3.0	8.7	-2.9	-2.1	-1.0	-2.0	0.3	-0.1
Lung cancer (father)	2.3	2.7	4.6	-2.1	-1.5	-1.0	-1.7	-1.6	-1.7
Leg fat mass (right)	2.3	9.0	15.6	-3.6	-3.0	-2.9	-1.2	-2.4	4.0
Trunk fat percentage	2.2	8.7	25.8	-3.1	-2.1	-2.6	-1.9	-1.4	5.1
Chronic bronchitis/emphysema (father)	2.2	2.5	5.0	-1.9	-2.2	-1.0	-1.7	0.1	1.6
Waist circumference	2.2	7.9	15.4	-3.1	-3.3	-2.8	-0.6	-1.8	3.9
Medication: Ramipril	2.2	2.8	7.5	-1.2	-1.9	-2.7	-1.9	-0.4	0.9
Illnesses of mother	2.2	2.7	5.3	0.6	1.4	2.0	1.6	1.6	-2.3
Whole body fat mass	2.2	9.1	19.4	-3.5	-2.8	-3.1	-1.5	-1.8	4.4
Maternal smoking around birth	2.1	3.0	5.9	-1.0	-2.4	-2.1	-1.9	0.0	1.7
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	7.2	1.2	1.1	2.2	0.5	-0.4	-2.7
Medication: Atenolol	2.1	2.6	4.8	0.4	-2.0	-1.9	-2.2	-1.6	0.4
High blood pressure (mother)	2.1	2.9	6.5	-1.2	-2.5	-1.6	-1.3	-1.5	1.8
Migraine (self-reported)	2.1	2.6	5.1	-2.3	-2.1	-1.6	-0.3	-1.2	1.5
Eye problems/disorders: Cataract	2.1	2.4	4.1	1.2	1.6	2.0	1.3	1.7	-1.3
HDL Cholesterol	2.0	3.4	6.1	-0.4	2.3	2.5	2.2	-0.4	-2.0
Severe depression (siblings)	2.0	2.2	6.0	-0.8	-1.8	-1.7	-0.8	0.0	2.4
Arm fat percentage (right)	2.0	8.0	21.2	-3.3	-1.3	-2.5	-1.3	-2.5	4.6
Age at first live birth	2.0	3.6	9.3	1.9	1.7	2.2	0.7	0.7	-3.0
Medication: Lisinopril	2.0	2.6	6.0	-0.2	-2.4	-1.4	-1.9	-2.0	-0.3
Alzheimer’s Disease (in mother)	1.9	2.2	3.7	1.5	1.9	1.6	1.3	1.0	-1.4
Hair/balding pattern: Pattern 2	1.9	2.5	6.1	-1.9	-1.5	-2.5	-0.7	0.7	1.4
Happiness	1.9	2.3	6.2	-2.5	-0.8	-1.2	-2.0	-1.1	-0.5
Emphysema/chronic bronchitis	1.9	2.1	5.3	-1.3	-2.3	-0.8	-1.5	-0.0	1.7
Bipolar Disorder or Schizophrenia	1.8	4.3	8.9	3.0	0.0	2.7	1.2	2.3	-1.7
Frequency of depressed mood in last 2 weeks	1.8	2.5	5.3	-2.3	-1.1	-2.0	-2.0	-0.3	0.4
Medication: Co-codamol	1.8	2.1	3.9	-1.1	-2.0	-1.2	-1.8	-1.2	1.2
Financial difficulties in last 2 years	1.8	2.5	7.7	-0.9	-1.2	-2.1	0.1	-0.7	2.8
Diabetes (self-reported)	1.8	2.8	5.2	-1.9	-1.8	-2.3	-0.9	0.9	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	4.6	-1.8	-2.1	-1.9	-1.6	-0.3	1.9
BMI	1.7	9.8	19.7	-4.4	-2.6	-3.1	-0.9	-2.6	3.8
Serious illness, injury or assault to yourself	1.7	2.0	5.6	-0.7	-2.4	-1.2	-1.6	1.1	-0.9
Trunk fat mass	1.7	7.2	19.1	-3.1	-2.3	-2.5	-1.2	-1.2	4.4
Hip circumference	1.7	7.5	12.0	-3.5	-3.0	-2.9	-0.7	-1.9	3.4
Arm fat mass (right)	1.7	7.1	15.0	-3.5	-2.1	-2.5	-0.9	-2.0	3.9
Medication: Aspirin	1.7	2.2	5.3	-0.4	-1.5	-1.4	-2.3	-1.6	0.9
Arm fat percentage (left)	1.7	7.0	18.0	-3.1	-1.1	-2.3	-1.2	-2.4	4.2
Arm fat mass (left)	1.7	6.8	13.9	-3.5	-2.0	-2.4	-0.8	-2.2	3.7
Depression (Nagel 2018)	1.6	2.4	4.7	-2.0	-1.1	-2.2	-1.5	-1.1	1.0
Schizophrenia (2018)	1.6	3.3	6.6	2.3	0.0	2.6	1.1	2.2	-1.3
Relative age of first facial hair	1.6	3.3	6.9	-2.1	-2.6	-2.0	-1.6	-1.3	-0.2
Body mass index (BMI)	1.6	6.7	12.8	-3.6	-2.1	-2.3	-0.9	-2.8	3.0
Number of incorrect matches in round	1.6	2.7	4.8	0.5	1.4	2.2	2.2	0.2	-2.2
Mouth/teeth dental problems: Dentures	1.6	2.8	4.7	-1.3	-1.9	-2.2	-0.9	-1.6	1.7
Pulse rate, automated reading	1.6	5.2	10.7	-3.3	-1.5	-1.7	-2.5	-2.5	1.7
Pain experienced in last month	1.6	2.7	7.2	1.4	1.7	1.7	-0.5	1.0	-2.7
Schizophrenia (2014)	1.5	3.4	7.1	1.8	0.0	2.5	1.0	2.7	-1.7
Number of treatments/medications taken	1.5	2.7	4.7	-2.2	-1.8	-1.5	-1.8	-1.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	6.4	-2.5	-1.4	-2.3	-2.5	-0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.0	-2.0	-1.9	-1.8	-1.2	-1.1	0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.6	1.9	1.9	1.1	1.3	2.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	4.5	0.2	1.2	0.2	2.1	-1.0	-1.9
Breast Cancer	1.4	3.3	6.3	0.3	-1.9	-1.9	-2.5	-2.2	-1.2
Body Mass Index (BMI) (2010)	1.4	1.9	6.6	2.6	1.7	-0.7	-0.3	1.1	-0.1
Blood Red Count	1.4	13.6	34.9	-3.3	-5.9	-4.9	-2.0	0.3	2.8
Taking other prescription medications	1.4	2.2	5.0	-1.9	-1.2	-2.2	-0.5	-0.3	1.6
Number of live births	1.4	2.0	8.2	-0.4	-1.3	-0.4	-0.7	-1.1	2.9
Noisy workplace	1.4	1.8	4.0	-1.5	-1.3	-1.1	-1.0	-0.5	2.0
Medication: Paracetamol	1.4	2.3	7.1	-1.9	-1.0	-1.2	-0.2	-2.7	-0.7
Health satisfaction	1.4	1.8	5.9	-2.4	-1.0	-0.3	-0.9	-1.5	1.1
Illnesses of father: None of the above (group 1)	1.4	1.8	5.7	0.4	1.6	1.3	2.4	0.6	0.1
Risk taking	1.4	2.0	3.3	1.5	1.8	0.9	1.7	1.6	0.1
Commuting to job workplace: Cycle	1.4	1.7	4.0	1.4	0.8	1.8	0.4	0.0	-2.0
Alzheimer’s Disease (including proxy)	1.3	1.9	2.8	1.5	1.6	1.7	1.2	1.3	-0.6
Blood White Count	1.3	10.0	21.9	-2.2	-3.6	-4.0	-1.7	1.2	4.7
Average weekly fortified wine intake	1.3	1.6	5.9	2.4	0.6	1.2	0.8	-1.0	-0.2
Medication: Blood pressure	1.3	2.3	5.2	-1.1	-2.3	-1.2	-1.4	-1.9	-0.7
Medication: Allopurinol	1.3	1.7	5.2	-0.2	0.4	1.1	2.3	-0.0	-1.9
Medication: Seretide 50 evohaler	1.3	1.5	3.3	-1.7	-1.4	0.1	-0.7	0.5	1.8
Overall health rating	1.3	2.9	4.9	-1.9	-2.2	-1.4	-1.2	-0.6	2.2
Lung FEV1/FVC ratio	1.2	5.9	22.0	-0.3	-2.5	-2.3	-1.3	-4.7	0.2
Had other major operations	1.2	1.5	6.8	-0.6	0.6	-0.5	0.9	0.6	2.6
Exposure to tobacco smoke outside home	1.2	1.6	5.7	-1.3	-0.9	-0.4	-0.2	1.2	2.4
Number of full brothers	1.2	1.5	5.9	0.2	-0.5	0.5	0.4	1.5	2.4
Shortness of breath walking on level ground	1.2	1.4	4.1	-2.0	-0.1	-0.4	-0.9	-1.9	0.3
Eye problems/disorders: None of the above	1.2	1.3	3.9	1.4	-0.8	-1.1	-0.5	0.2	2.0
Medication: Aspirin	1.2	1.6	3.3	-0.1	-1.4	-1.1	-1.8	-1.7	0.3
Medication: Metformin	1.1	1.6	2.8	-0.1	-0.3	-1.6	-1.5	1.4	1.7
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.8	-1.1	-1.3	-2.4	-1.3	-0.1	0.5
Gout (self-reported)	1.1	1.5	3.8	-0.1	0.3	1.1	2.0	0.2	-1.9
Medication: Omeprazole	1.1	1.3	3.6	-1.4	-1.0	-0.7	-0.4	-0.9	1.9
Fractured/broken bones in last 5 years	1.1	1.4	5.0	-0.7	-0.2	1.6	0.1	2.2	-0.7
Bipolar Disorder (2018)	1.0	1.5	4.5	2.1	0.0	1.3	0.8	1.0	-1.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.8	0.5	-0.4	-2.0	-2.2	2.1	0.6
Rheumatoid Arthritis	1.0	1.3	4.7	-2.2	-1.2	-1.0	-0.0	-0.3	0.8
Relative age voice broke	1.0	1.6	4.0	-1.0	-2.0	-1.0	-1.3	-0.9	1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.9	0.0	0.8	2.0	1.3	0.7	0.0
Sitting height	1.0	7.4	17.1	1.5	2.5	2.5	3.0	2.0	-4.1
Had menopause	1.0	1.2	3.5	-0.4	-1.9	-1.4	-1.2	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	4.5	-2.1	-1.1	-2.1	-2.0	-0.3	0.4
Pulse rate	1.0	1.7	3.1	-1.7	0.4	-0.6	-1.3	-1.5	1.8
Guilty feelings	1.0	1.6	3.6	0.8	1.0	1.9	0.9	1.6	1.0
Age at First Birth	0.9	1.3	2.7	1.5	0.6	1.6	1.0	-0.8	-0.7
Mean Putamen Volume	0.9	1.1	3.6	0.4	0.7	-0.6	-1.9	-0.1	1.3
Primary Biliary Cirrhosis	0.9	1.3	2.3	-1.3	-1.2	-1.3	-0.1	-1.5	-0.6
Blood Eosinophil Count	0.9	7.1	30.6	1.0	1.4	-0.6	1.8	2.3	5.5
Average weekly spirits intake	0.9	1.2	2.5	-1.6	-0.6	-0.8	1.6	-0.1	1.0
Diabetes (mother)	0.9	1.2	3.0	-0.6	-1.7	-1.6	0.5	-1.1	-0.2
Supplements: Glucosamine	0.9	1.2	2.4	-1.5	-1.3	-1.1	-0.2	-1.3	0.6
Illnesses of siblings	0.9	1.2	2.4	-1.6	1.5	0.6	0.1	-0.6	-1.3
Falls in the last year	0.9	1.2	3.7	0.0	-1.9	-0.7	-1.3	-0.0	1.2
Depression (self-reported)	0.9	1.1	4.6	-0.5	0.2	0.5	0.5	-1.1	-2.1
Length of working week for main job	0.9	1.0	3.9	0.2	-0.4	-0.0	1.2	2.0	-0.8
Birth weight	0.9	1.9	5.1	0.3	2.3	0.6	0.9	2.0	1.1
Comparative height size at age 10	0.9	5.1	9.3	3.0	0.3	2.0	2.7	2.6	-1.7
Chest pain or discomfort	0.9	1.3	4.7	0.0	-1.0	-0.1	0.3	1.5	2.2
Had major operations	0.9	1.1	5.4	0.5	0.2	0.6	-0.6	0.5	-2.3
Family relationship satisfaction	0.9	1.2	2.8	-1.1	-1.7	-1.0	-0.4	0.1	-1.3
Ever taken oral contraceptive pill	0.9	1.0	4.3	-0.1	-0.4	-0.9	0.2	-0.6	2.1
Mother’s age at death	0.9	1.1	3.2	-0.6	1.4	0.4	1.8	-0.2	0.9
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.8	0.7	0.2	0.7	1.5	0.8	1.7
Average weekly beer plus cider intake	0.9	1.3	2.2	-1.4	-0.8	-1.1	-1.5	-0.3	1.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.7	0.5	0.7	0.9	1.6	1.0	-0.9
Intelligence (Savage-Jansen 2018)	0.8	2.4	5.5	1.9	1.8	0.6	-1.1	2.4	-0.7
Triglycerides	0.8	1.4	2.8	-0.4	-1.4	-1.2	-1.3	0.1	1.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.1	-1.8	-1.2	-0.4	0.1	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.0	-0.2	-0.9	-1.7	-1.1	-0.5	0.1
Alcohol usually taken with meals	0.8	1.3	3.0	1.4	0.9	-0.1	0.8	-1.7	-1.1
Weight	0.8	4.1	7.3	-2.7	-2.2	-2.1	-0.1	-1.0	2.6
Medication: Cholesterol lowering	0.8	1.2	2.1	-1.5	-0.9	-0.5	-1.4	-1.4	0.2
Impedance of arm (left)	0.8	3.9	9.5	2.3	3.1	1.5	-0.8	2.2	0.8
Tense / ‘highly strung’	0.8	1.4	2.3	-1.4	-1.5	0.0	0.8	-1.5	-1.1
Knee pain experienced in last month	0.8	1.2	5.3	0.2	0.2	-1.2	0.4	-0.2	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.2	-1.8	-1.1	-0.8	-0.6	-0.3	0.4
Medication: Gliclazide	0.8	0.9	2.4	-1.0	-1.6	-0.8	-0.6	-0.3	1.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.6	0.3	-1.9	-0.6	-0.4	-1.0	-0.0
Eye problems/disorders: Glaucoma	0.8	0.9	2.5	-1.5	-0.6	-0.3	0.3	-1.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.0	-1.0	-0.5	-0.2	-1.7	-0.9	1.1
Alcohol drinker status: Never	0.8	0.9	2.5	-0.6	0.2	0.5	-1.6	-1.6	-0.2
Number of operations (self-reported)	0.8	1.2	4.8	-0.4	-0.5	-0.5	1.3	2.2	0.5
Ever depressed for a whole week	0.8	0.9	2.6	1.1	-1.6	-0.6	-0.8	-0.3	-0.8
Lupus	0.7	1.1	2.8	0.3	-0.4	-1.7	-1.5	0.3	-0.9
Exposure to tobacco smoke at home	0.7	0.8	1.8	0.1	0.5	1.0	-1.0	-0.9	1.3
Breastfed as a baby	0.7	0.9	1.9	1.3	-0.1	0.1	-0.1	1.4	1.4
Medication: Amlodipine	0.7	0.9	1.9	0.1	-1.2	-0.6	-1.1	-0.7	-1.4
Number of full sisters	0.7	0.9	4.6	-2.1	-0.2	-0.2	-0.6	-0.3	0.4
Leg pain on walking	0.7	0.9	2.0	-1.4	-0.5	-1.2	0.2	-0.4	1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.3	-0.3	0.2	-0.4	1.8	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	5.0	-0.3	-0.6	-1.1	-0.9	2.2	-1.0
Friendships satisfaction	0.7	0.9	2.8	-1.7	-1.4	-0.5	-0.2	-0.5	0.2
Osteoporosis (self-reported)	0.7	0.9	2.3	-0.0	0.9	0.9	1.5	0.2	-1.3
Average weekly champagne plus white wine intake	0.7	1.0	4.0	-0.5	0.3	0.7	2.0	-0.8	-0.5
Miserableness	0.7	1.2	3.7	-1.2	-1.9	-0.9	-0.4	-0.8	-0.7
Wears glasses or contact lenses	0.7	0.8	4.6	2.1	0.3	0.3	0.3	0.2	0.0
Hearing aid user	0.7	0.8	3.7	-0.4	-0.9	0.4	-0.1	0.2	1.9
Commuting to job workplace: Public transport	0.7	0.8	1.5	-0.2	-1.2	-0.7	-1.2	1.0	0.7
Arm fat-free mass (left)	0.7	3.6	10.0	-2.4	-3.2	-2.1	0.5	-0.5	1.1
Arm predicted mass (left)	0.7	3.5	9.1	-2.5	-3.0	-1.9	0.6	-0.5	1.2
Reaction Time	0.6	1.1	2.5	-0.2	-1.2	-1.6	-1.2	-1.0	0.7
Coronary Artery Disease (CAD)	0.6	0.7	4.4	0.0	0.0	0.0	0.0	0.0	-2.1
HbA1C	0.6	0.6	3.3	1.8	0.4	0.3	0.4	-0.3	0.1
Vitamin and mineral supplements	0.6	0.8	2.5	0.6	0.1	0.4	1.6	1.2	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	-0.6	-0.7	-1.4	-0.6	-0.4	1.2
Impedance of arm (right)	0.6	2.7	5.6	1.9	2.4	1.1	-0.9	1.9	1.0
Alcohol intake versus 10 years previously	0.6	0.8	2.2	-1.1	-1.5	-0.2	-0.6	-1.0	0.2
Worrier / anxious feelings	0.6	1.1	2.1	-0.2	-1.4	-1.1	-1.2	-1.0	1.0
Glaucoma (self-reported)	0.6	0.7	3.9	-2.0	-0.2	-0.4	-0.3	-0.4	0.0
Medication: Ibuprofen	0.6	0.7	1.3	0.6	0.8	0.9	1.1	-0.8	0.8
Arm predicted mass (right)	0.6	2.9	8.7	-2.2	-3.0	-1.9	0.4	-0.3	0.2
Age at last live birth	0.6	0.9	4.0	0.8	0.9	0.4	-0.1	0.1	-2.0
Smoking status: Previous	0.6	1.0	1.9	1.0	0.5	0.8	1.3	-0.4	-1.4
Average weekly red wine intake	0.6	1.0	2.1	-0.3	-1.4	-1.1	-0.8	-0.7	-1.1
Illnesses of father: High blood pressure	0.6	0.8	1.5	-1.2	-0.8	-1.0	-0.7	0.0	0.9
Cholesterol lowering medication	0.6	0.8	2.1	0.2	-0.9	-0.5	-1.5	-0.7	1.1
Alzheimer’s Disease (in father)	0.5	0.5	1.5	-0.6	-1.2	-0.3	-0.8	0.0	0.9
Fed-up feelings	0.5	0.9	2.1	-0.5	-1.5	-0.9	-0.9	0.9	0.8
Impedance of leg (left)	0.5	2.6	7.4	-0.9	-1.2	-1.3	-1.9	0.5	2.7
Hearing difficulty/problems with background noise	0.5	0.8	1.9	-1.2	-1.4	-1.1	-0.4	-0.3	-0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.3	-0.6	-0.9	-0.1	1.1	0.9
Fluid intelligence score	0.5	1.1	2.1	1.4	0.4	-0.8	-1.4	1.2	-0.4
Father’s age at death	0.5	0.7	2.0	0.5	1.1	0.4	1.4	-0.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.8	-0.0	0.2	-0.3	1.0	-0.9	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	1.4	0.2	1.0	0.5	-0.3	0.4
Pulse wave reflection index	0.5	0.7	1.1	1.1	0.6	1.1	1.0	-0.6	0.2
Blood clot in the leg (DVT)	0.5	0.6	1.1	-1.0	0.6	1.0	0.7	0.6	-0.6
High blood pressure (siblings)	0.5	0.8	2.7	1.6	-1.4	0.1	0.2	0.1	-0.3
Arm fat-free mass (right)	0.5	2.6	8.0	-1.9	-2.8	-1.9	0.3	-0.4	0.3
Comparative body size at age 10	0.5	1.5	2.6	0.8	0.9	0.9	1.6	-1.6	-1.1
Pulse wave peak to peak time	0.5	0.6	2.1	-1.4	-0.4	-0.9	-0.5	0.6	-0.3
Illnesses of father: Heart disease	0.5	0.6	1.7	1.3	0.3	-0.1	-0.8	-0.7	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.1	-0.8	0.8	-0.5	1.1	0.5	0.5
Financial situation satisfaction	0.5	0.6	2.2	-1.5	0.5	0.1	0.8	-0.3	-0.8
High cholesterol (Self-reported)	0.5	0.9	2.9	-0.7	-0.3	0.3	-1.7	-1.3	0.4
Irritability	0.5	0.9	2.1	-1.2	-0.7	-0.9	0.2	0.9	1.5
Supplements: Calcium	0.5	0.6	1.5	-0.9	-0.8	0.2	-1.2	0.8	-0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.4	1.2	-0.7	0.7	-0.6	-0.5	-1.0
Schizophrenia vs Biploar Disorder	0.4	0.6	1.2	-1.1	0.0	-0.2	-1.0	1.1	0.0
LDL Cholesterol	0.4	0.6	1.7	0.3	0.5	1.3	-0.3	-0.5	-1.2
Waist Hip Ratio (WHR)	0.4	1.9	5.5	-0.2	-1.5	-1.4	-0.9	1.1	2.3
Hypothyroidism (self reported)	0.4	0.8	2.2	-1.0	0.2	-0.7	0.8	1.5	-0.7
Neuroticism	0.4	0.9	4.3	-0.4	-2.1	-0.8	0.2	0.3	0.6
Hand grip strength (left)	0.4	1.1	3.3	-1.8	-1.5	-0.5	-0.6	0.2	0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	0.0	-0.7	-0.8	-1.2	-0.7	0.3
Supplements: Zinc	0.4	0.4	1.7	-0.4	-0.1	0.3	-1.3	-0.4	0.7
Hand grip strength (right)	0.4	1.1	4.1	-2.0	-1.3	-0.4	-0.9	-0.2	-0.1
Townsend deprivation index at recruitment	0.4	0.6	1.6	-0.1	-0.6	0.3	-1.3	0.4	1.1
Age when periods started (menarche)	0.4	0.9	1.9	-0.4	1.2	0.9	-1.4	1.0	-0.5
Stomach or abdominal pain in last month	0.4	0.5	1.4	-0.8	0.2	-0.0	1.2	0.8	-0.4
Mouth/teeth dental problems	0.4	0.6	2.1	0.2	0.4	0.6	-0.2	1.0	-1.5
Heart attack	0.4	0.6	0.9	1.0	-0.8	0.6	-0.7	-0.6	-0.8
Time employed in main current job	0.4	0.5	1.0	-0.6	-0.8	1.0	0.2	0.9	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.0	0.3	-0.7	0.2	-0.4	1.4	-0.1
Medication: Lansoprazole	0.4	0.5	1.6	0.2	-0.1	-0.9	-1.2	-0.7	0.1
Prospective memory result	0.4	0.5	2.0	-0.8	0.5	0.7	1.4	-0.1	-0.2
Birth weight of first child	0.4	0.7	1.3	0.4	1.0	-0.2	1.1	0.8	1.1
Peak expiratory flow (PEF)	0.4	1.0	2.2	1.5	1.0	-0.5	1.3	0.2	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-0.1	-0.3	-0.7	1.1	-0.0	1.1
Loud music exposure frequency	0.4	0.4	0.7	-0.8	0.4	-0.4	0.6	0.8	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	1.4	0.4	0.7	-0.2	-0.1	0.2
Neck or shoulder pain in last month	0.4	0.5	1.6	0.3	-0.1	-0.8	0.6	-0.6	1.3
Mean time to correctly identify matches	0.4	0.8	1.4	-0.0	-1.0	-0.9	-1.2	-0.9	1.0
Heart disease (mother)	0.4	0.5	1.2	0.3	-0.7	-1.1	-0.6	-0.0	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	-0.8	1.0	-0.3	0.5	-0.4	0.7
Loneliness, isolation	0.4	0.5	1.7	-0.5	-0.4	-0.6	-0.7	0.5	1.3
Back pain experienced in last month	0.4	0.6	1.9	-0.4	0.5	0.6	1.4	-0.3	0.9
Osteoarthritis (self-reported)	0.4	0.5	1.6	0.2	-0.1	0.0	1.0	-1.3	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.2	-0.6	0.7	0.9	0.5	1.1	-0.4
Alcohol drinker status: Previous	0.4	0.5	1.7	-1.3	-0.9	-0.2	-0.4	-0.5	-0.0
Impedance of whole body	0.4	1.9	3.6	1.0	1.3	0.4	-1.2	1.8	1.9
Fasting Glucose	0.3	0.4	1.0	1.0	-0.5	0.1	-0.2	-0.4	-0.8
Neuroticism (2016)	0.3	0.4	0.9	-1.0	-0.6	-0.5	-0.0	-0.4	-0.8
Height	0.3	5.9	14.4	1.9	-3.1	-2.0	-0.1	3.8	2.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.7	-0.4	0.1	-0.9	-0.8	0.2
Medication for hormone replacement therapy	0.3	0.3	1.2	0.1	-0.3	0.2	-0.4	0.5	-1.1
Impedance of leg (right)	0.3	1.6	4.9	-0.2	-1.0	-1.0	-1.4	0.7	2.2
Medication: Levothyroxine sodium	0.3	0.5	1.3	-1.1	-0.2	-0.5	0.2	0.4	-1.0
Medication: Simvastatin	0.3	0.4	1.8	-0.4	-0.6	0.1	0.3	0.2	1.3
Standing height	0.3	2.8	12.1	1.4	-0.6	0.0	1.5	3.5	-0.5
Headache pain in last month	0.3	0.5	1.4	-0.4	-0.8	-0.4	0.6	0.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	-1.2	0.1	-0.2	1.0	0.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	-1.2	0.0	0.0	-0.7	0.1	0.7
Number of children fathered	0.3	0.3	1.4	1.2	-0.4	-0.5	0.1	-0.4	0.4
Alcohol intake frequency.	0.3	0.8	3.0	-0.6	-0.4	0.4	-1.7	-0.6	0.7
Mood swings	0.3	0.5	1.2	-0.6	-1.1	-0.6	1.1	-0.1	0.4
Ever had bowel cancer screening	0.3	0.3	0.9	0.9	-0.2	-0.3	-0.5	-0.0	0.7
Mineral and other dietary supplements	0.3	0.4	1.6	0.3	0.3	0.6	1.3	0.6	-0.1
Medication: Paracetamol	0.3	0.5	2.0	-0.9	-0.0	0.1	0.1	-1.4	-0.2
Basal metabolic rate	0.3	1.6	3.9	-1.7	-2.0	-1.4	0.6	-0.2	0.8
Age started oral contraceptive pill	0.3	0.4	0.9	1.0	-0.2	0.6	0.7	-0.5	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	0.0	0.4	0.4	0.8	1.1	0.6
Depressed Affect (Nagel 2018)	0.2	0.3	1.0	-0.0	-1.0	-0.5	0.5	0.7	-0.1
Worry (Nagel 2018)	0.2	0.4	1.1	0.1	-0.8	-0.2	-0.5	-0.6	-1.0
Heel T-Score	0.2	1.6	5.0	-0.6	-0.3	-0.5	-0.2	-1.9	-2.2
Chronotype (morning person)	0.2	0.4	0.7	-0.7	-0.2	-0.8	-0.5	-0.7	-0.6
Hair Pigment	0.2	5.2	21.9	0.8	-1.2	-2.4	-1.1	0.5	4.7
Sensitivity / hurt feelings	0.2	0.3	0.6	0.7	0.2	0.2	-0.0	-0.7	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.7	-0.7	0.1	0.8	-0.0	0.2
Nervous feelings	0.2	0.4	0.6	0.5	-0.8	0.7	-0.7	0.6	-0.1
Trunk fat-free mass	0.2	1.0	2.7	-0.7	-1.6	-0.7	1.5	0.1	-0.6
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	-0.2	-0.2	-0.8	-0.0	-0.7	-1.0
Trunk predicted mass	0.2	1.1	2.6	-0.7	-1.6	-0.8	1.5	0.1	-0.6
Worry too long after embarrassment	0.2	0.3	0.9	0.5	-0.1	0.8	-0.2	0.9	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.0	0.0	-0.3	-0.4	-0.5	-0.1	1.0
Supplements: Vitamin C	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.3	-0.6	0.3
Whole body fat-free mass	0.2	1.0	3.0	-1.1	-1.7	-0.9	0.9	0.1	-0.1
Qualifications: nursing, teaching	0.2	0.3	0.7	0.1	0.4	-0.6	0.0	-0.9	-0.8
Whole body water mass	0.2	1.0	3.1	-1.1	-1.8	-0.9	0.9	0.1	-0.1
Heart disease (siblings)	0.2	0.2	0.8	0.4	-0.3	-0.9	0.2	-0.1	0.2
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.5	-0.9	-0.4	0.2	0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	-0.6	0.0
Tanning	0.1	1.2	4.2	-0.3	-0.2	-0.3	1.0	-1.3	-2.0
Leg fat-free mass (left)	0.1	0.7	1.6	-1.2	-1.3	-0.9	0.5	0.1	0.2
Multivitamins +/- minerals	0.1	0.2	0.4	-0.1	-0.2	0.3	-0.5	-0.6	-0.6
Leg predicted mass (left)	0.1	0.7	1.5	-1.2	-1.2	-0.9	0.5	0.1	0.3
Past tobacco smoking	0.1	0.1	0.2	0.4	0.3	0.3	-0.4	0.3	0.1
Qualifications: None of the above	0.1	0.3	0.8	-0.4	-0.5	0.9	0.7	-0.3	-0.3
Neuroticism score	0.1	0.3	0.7	-0.2	-0.8	0.4	0.3	0.6	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.5	-1.2	0.1	-0.3	-0.1	0.1	-0.4
Suffer from ‘nerves’	0.1	0.2	0.6	-0.2	0.0	0.2	-0.8	-0.7	-0.4
Leg fat-free mass (right)	0.1	0.6	1.6	-1.3	-1.1	-0.9	0.4	0.1	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.2	-0.1	0.2	-0.1	0.1	0.6
Leg predicted mass (right)	0.1	0.7	1.7	-1.3	-1.2	-0.9	0.4	0.0	0.1
Ever smoked	0.1	0.1	0.4	-0.1	-0.2	-0.6	0.4	-0.2	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	0.0	-0.2

Hub : Genes

GMEB2

Models

Trait associations