Hub : Genes

RTEL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1900	0.0660	6.3e-04	0.057	NA	0.114	NA	0.141	0.00160	NA	9.5e-06	NA	8.0e-07
2	METSIM	Adipose	0.0719	0.0231	5.3e-06	0.005	0.031	0.033	0.032	0.027	0.05000	1.5e-05	9.2e-06	1.2e-05	6.1e-05
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0490	0.0320	5.3e-03	0.043	0.030	0.018	NA	0.023	0.00064	4.1e-03	2.0e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.5	2.4	1.6	-1.0	1.0
Bipolar Disorder or Schizophrenia	2.3	5.5	11.0	3.3	-0.8	2.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	-0.7	-0.8	0.1
Depression (Nagel 2018)	1.6	2.4	4.8	-1.6	0.3	-2.2
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.1	2.0	1.8	-0.6
Neuroticism (Nagel 2018)	0.7	1.7	3.7	0.1	-1.9	1.1
Schizophrenia (2018)	2.1	4.3	8.7	3.0	-0.1	2.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.4	0.0	-0.8
Worry (Nagel 2018)	1.5	3.2	6.9	0.1	-2.6	1.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.0	0.4	-1.0	0.9
Alzheimer’s Disease (in father)	0.9	0.9	2.1	-0.7	1.5	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.5	-0.2	1.0
Crohns Disease (2017)	22.0	48.2	58.6	-7.1	5.9	-7.7
Irritable Bowel Disease (IBD)	28.8	68.7	87.6	-8.8	6.4	-9.4
Ulcerative Colitis (UC)	18.0	33.7	45.0	-6.2	4.2	-6.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.1	2.2	3.0	-1.7	-1.1	-1.6
Verbal and Numeric Reasoning (VNR)	2.4	5.7	11.3	0.3	3.4	-2.4
Breast Cancer	0.1	0.3	0.5	-0.1	-0.7	-0.6
Ovarian Cancer	6.3	8.4	12.4	-2.0	3.5	-2.9
Prostate Cancer	17.2	24.2	40.2	-3.7	4.3	-6.3
Age at First Birth	1.9	2.8	6.3	2.5	1.1	1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	-0.8	0.7	-0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	0.0	-0.3
Crohns Disease (2012)	17.1	27.5	43.0	-6.3	0.0	-6.6
Mean Putamen Volume	0.3	0.3	0.5	-0.6	0.7	-0.3
Fasting Glucose	1.9	2.2	5.3	0.6	-2.3	1.0
HbA1C	0.1	0.1	0.2	-0.2	-0.1	0.4
HDL Cholesterol	2.0	3.3	6.8	1.2	-1.3	2.6
LDL Cholesterol	1.8	2.8	5.2	2.3	0.5	1.7
Lupus	0.2	0.3	0.6	0.5	-0.8	-0.2
Neuroticism (2016)	1.1	1.6	4.5	0.3	-2.1	0.4
Primary Biliary Cirrhosis	2.1	2.9	5.2	-2.3	0.8	-1.7
Rheumatoid Arthritis	1.5	2.0	5.1	-2.3	-0.6	-0.8
Schizophrenia (2014)	1.4	3.0	6.8	2.6	-0.2	1.5
Triglycerides	1.3	2.2	3.5	-0.1	1.7	-1.9
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.9	0.0	0.0	-1.7
Ulcerative Colitis	18.4	26.6	44.3	-6.7	0.0	-6.0
Blood Eosinophil Count	0.7	5.2	7.6	-1.3	2.7	-2.6
Blood Platelet Count	2.9	33.1	59.9	-5.3	3.3	-7.7
Blood Red Count	2.6	25.1	45.0	-4.6	3.0	-6.7
Blood White Count	3.5	25.9	39.7	-5.0	3.6	-6.3
Heel T-Score	1.3	10.4	14.2	2.0	-3.8	3.6
BMI	1.7	9.9	24.2	-4.9	-0.7	-2.2
Height	1.1	21.6	42.6	-1.2	4.6	-6.5
Waist Hip Ratio (WHR)	0.5	2.4	3.4	1.1	1.8	-1.6
Systolic Blood Pressure	1.5	7.4	15.0	-2.6	0.9	-3.9
Smoking Status	7.0	16.8	28.7	-5.4	1.1	-4.5
Allergy or Eczema	11.7	30.9	42.9	-6.1	3.6	-6.5
Cardiovascular Disease	1.9	6.4	10.7	-2.4	1.6	-3.3
Hypothyroidism (self reported)	2.1	4.7	10.2	0.8	-3.2	1.8
Respiratory disease	5.2	11.6	17.4	-4.0	1.3	-4.2
Type 2 Diabetes (T2D) (2018)	4.5	8.5	14.0	-2.1	2.7	-3.7
Lung FEV1/FVC ratio	0.7	3.3	6.1	-2.5	-0.8	-1.8
Lung FVC	14.9	75.7	125.4	6.4	-7.8	11.2
Neuroticism	0.6	1.4	3.7	-0.5	-1.9	0.4
Chronotype (morning person)	0.7	1.5	3.1	-1.8	1.1	-0.6
Hair Pigment	0.4	12.8	16.0	-3.5	3.2	-4.0
Tanning	0.1	1.4	2.2	0.2	-1.5	1.4
Hand grip strength (left)	1.3	3.3	8.1	-0.8	2.9	-1.1
Number of treatments/medications taken	1.6	3.0	4.6	-2.1	0.6	-2.0
Average weekly spirits intake	1.3	1.6	4.4	-2.1	-0.1	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.0	0.6	-1.0	0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	-1.0	-0.2	-1.5
Hearing difficulty/problems: Yes	0.4	0.6	1.8	-0.2	-1.4	-0.0
Relative age of first facial hair	0.5	1.1	1.9	-1.4	-0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	2.9	-1.7	-1.4	-1.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.3	-0.8	0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.8	-0.3	0.2
Systolic blood pressure, automated reading	3.2	9.2	16.0	-3.3	1.1	-4.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.0	-0.2	-0.2
Angina	0.2	0.3	0.6	0.4	-0.8	0.3
Medication for hormone replacement therapy	1.8	2.0	3.8	0.9	-1.9	1.2
Vitamin and mineral supplements	0.0	0.0	0.0	0.2	0.2	0.2
Supplements: Zinc	0.3	0.3	0.4	0.6	-0.3	0.6
Medication: Co-codamol	1.5	1.7	2.8	-1.2	0.9	-1.7
Medication: Metformin	2.2	3.2	5.0	-0.8	2.2	-2.0
Diabetes (father)	0.8	1.0	1.4	-1.2	0.3	-1.2
Diabetes (mother)	0.6	0.8	1.6	-1.3	-0.3	-0.8
Severe depression (siblings)	2.6	2.9	4.5	-1.9	0.6	-2.1
Pack years adult smoking proportion	3.4	5.1	7.1	-2.7	1.1	-2.6
Impedance of leg (right)	1.8	8.7	14.7	-0.5	3.8	-3.3
Leg fat-free mass (left)	0.3	1.6	3.2	-1.8	-0.3	-1.2
Trunk fat percentage	3.3	13.0	19.2	-4.4	2.0	-4.0
Hand grip strength (right)	0.7	1.8	3.8	-0.4	1.9	-1.2
Townsend deprivation index at recruitment	0.2	0.2	0.3	0.5	-0.6	0.2
Current tobacco smoking	13.4	22.0	31.5	-5.1	2.8	-5.6
Average weekly fortified wine intake	1.2	1.4	2.3	1.5	-0.6	1.3
Maternal smoking around birth	2.7	3.9	9.3	-3.0	0.2	-1.5
Fed-up feelings	0.5	1.0	1.6	-1.3	-1.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	4.2	5.6	9.5	-2.3	1.5	-3.1
Relative age voice broke	0.4	0.6	1.7	-1.3	-0.1	0.0
Taking other prescription medications	1.9	3.0	5.5	-2.4	0.4	-1.8
Age when periods started (menarche)	0.3	0.7	1.6	1.3	0.7	-0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-1.1	-0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.9	-0.7	-2.0	0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	0.6	-0.7	1.2
Qualifications: CSEs or equivalent	1.6	2.1	3.5	-1.9	0.4	-1.7
Serious illness, injury or assault to yourself	1.3	1.6	3.1	0.2	1.3	-1.7
High blood pressure	1.4	3.8	6.7	-2.1	0.7	-2.6
Hayfever, allergic rhinitis or eczema	11.8	25.6	31.4	-5.3	4.2	-5.6
Multivitamins +/- minerals	0.2	0.3	0.4	0.6	-0.4	0.4
Stomach or abdominal pain in last month	0.5	0.6	0.7	-0.6	-0.9	0.8
Supplements: Glucosamine	1.3	1.7	3.3	-1.8	0.2	-1.3
Diverticular disease/diverticulitis (self-reported)	3.1	3.6	8.9	3.0	-1.0	1.0
Medication: Atenolol	2.3	2.9	5.5	-2.4	1.2	-1.2
Medication: Levothyroxine sodium	1.1	1.8	4.2	-0.0	-2.1	1.1
Sitting height	0.5	3.8	6.8	2.6	-1.7	1.3
Chronic bronchitis/emphysema (father)	2.2	2.6	4.9	-1.6	0.4	-2.2
High blood pressure (mother)	1.4	2.0	2.8	-1.0	1.7	-1.5
Body mass index (BMI)	1.5	6.5	14.8	-3.8	-0.2	-2.2
Impedance of leg (left)	1.9	9.3	13.9	-0.9	3.7	-3.6
Leg predicted mass (left)	0.3	1.6	3.3	-1.8	-0.3	-1.2
Trunk fat mass	3.0	12.7	19.1	-4.4	1.7	-4.0
Waist circumference	2.4	8.7	14.0	-3.7	0.9	-3.4
Number of incorrect matches in round	4.5	7.5	10.7	2.2	-2.7	3.3
Past tobacco smoking	1.2	2.2	3.4	1.8	1.7	0.5
Alcohol usually taken with meals	1.2	2.0	4.7	0.2	-2.2	1.1
Nervous feelings	1.2	2.3	3.0	1.2	-1.6	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.9	-1.7	-0.4	-1.6
Hearing difficulty/problems with background noise	0.5	0.9	1.7	-1.3	-0.6	-0.7
Hair/balding pattern: Pattern 2	2.6	3.3	5.7	-1.7	1.2	-2.4
Had menopause	0.8	1.0	2.5	-0.5	-0.5	-1.6
Had other major operations	1.1	1.4	2.1	-1.5	1.1	-0.9
Forced vital capacity (FVC)	6.9	26.5	43.7	5.1	-3.1	6.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.8	-0.9	-1.4	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	-1.2	-0.1	-0.5
Qualifications: None of the above	0.2	0.4	0.5	-0.4	-0.7	0.7
Financial difficulties in last 2 years	1.6	2.2	3.8	-1.1	1.2	-2.0
Mouth/teeth dental problems	0.5	0.8	1.1	1.0	-0.7	1.0
Heart attack	0.4	0.5	1.3	0.0	-0.6	1.1
Allergy	10.9	25.0	33.6	5.5	-3.3	5.8
Pain all over the body in last month	5.2	5.6	9.8	-2.5	0.7	-3.1
Diabetes (self-reported)	2.3	3.5	6.6	-1.2	1.6	-2.6
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	4.3	-1.1	1.8	-2.1
Medication: Ramipril	4.0	5.1	7.0	-2.6	1.3	-2.7
Medication: Simvastatin	0.6	0.9	2.2	-0.3	1.5	-0.6
Fluid intelligence score	1.1	2.3	3.8	1.0	2.0	-1.5
Illnesses of siblings	0.2	0.3	0.4	-0.6	0.6	0.3
Neuroticism score	0.4	0.9	2.5	-0.1	-1.6	0.5
Weight	1.6	8.0	13.2	-3.6	0.7	-3.2
Impedance of arm (right)	0.7	3.3	6.1	2.0	2.5	0.0
Arm fat percentage (right)	2.0	7.8	14.4	-3.8	1.1	-2.8
Trunk fat-free mass	0.2	1.2	1.8	-1.2	-0.7	-1.3
Hip circumference	3.0	13.1	26.1	-5.1	0.4	-3.6
Time employed in main current job	0.4	0.5	0.7	0.4	-0.8	0.8
Alcohol intake versus 10 years previously	0.5	0.7	0.9	-0.8	-1.0	-0.7
Father’s age at death	0.0	0.0	0.1	0.1	0.1	0.3
Worrier / anxious feelings	0.3	0.6	0.9	-0.4	-0.8	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	6.0	-2.1	0.7	-2.4
Falls in the last year	0.1	0.1	0.3	-0.0	-0.6	-0.2
Hair/balding pattern: Pattern 3	0.6	0.9	1.6	-1.0	-1.3	-0.2
Number of live births	1.1	1.5	2.2	-1.2	1.5	-0.8
Forced expiratory volume in 1-second (FEV1)	4.6	15.4	26.3	3.8	-2.4	5.1
Pulse rate	0.4	0.7	1.2	-0.3	1.0	-1.1
Happiness	2.1	2.6	5.0	-1.6	-2.2	0.4
Noisy workplace	0.5	0.6	1.3	-1.1	0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.4	1.2	-0.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	2.5	1.2	1.6	-1.4
Mouth/teeth dental problems: Dentures	3.3	5.6	10.6	-3.3	0.7	-2.4
Asthma	5.0	9.8	13.4	-3.7	1.8	-3.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-1.0	-0.9	0.1
Medication: Cholesterol lowering	0.0	0.1	0.1	-0.1	-0.4	0.2
Depression (self-reported)	2.6	3.2	3.4	1.8	-1.8	1.7
Medication: Lansoprazole	0.3	0.3	0.8	0.1	-0.5	-0.9
Prospective memory result	0.1	0.2	0.4	-0.1	-0.3	0.6
Lung cancer (father)	0.6	0.7	1.1	-0.6	-0.8	-1.0
Illnesses of mother	1.9	2.4	3.3	1.6	-1.2	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	4.3	13.9	24.2	3.0	-2.9	4.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.9	-0.5	0.1
Impedance of arm (left)	0.7	3.2	5.8	2.0	2.4	0.2
Arm fat mass (right)	2.0	8.3	15.4	-3.9	0.6	-3.0
Trunk predicted mass	0.2	1.3	1.9	-1.2	-0.7	-1.4
Standing height	0.4	3.5	6.7	0.1	2.0	-2.6
Length of working week for main job	0.3	0.3	0.6	-0.8	0.5	-0.3
Exposure to tobacco smoke at home	0.6	0.6	1.5	-0.3	-1.2	0.6
Breastfed as a baby	0.4	0.4	1.0	0.0	1.0	-0.6
Tense / ‘highly strung’	1.7	2.8	6.9	-0.9	-2.6	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	7.8	-2.8	1.2	-2.5
Hair/balding pattern: Pattern 4	0.3	0.8	2.3	0.1	-1.5	-0.1
Birth weight of first child	0.3	0.6	1.4	-1.2	-0.5	-0.1
Peak expiratory flow (PEF)	0.2	0.5	1.0	-0.6	1.0	0.5
Pulse wave reflection index	1.6	2.0	3.2	0.5	-1.6	1.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.6	0.0	0.1
Loud music exposure frequency	0.3	0.3	0.5	-0.7	-0.7	0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.5	-0.5	0.7	-1.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.4	-0.2	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.6	-0.2	-0.2
Medication: Paracetamol	1.3	2.1	6.0	-0.4	-2.4	0.3
Headache pain in last month	0.2	0.3	0.8	0.3	-0.9	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	0.8	0.4	0.5
Glaucoma (self-reported)	0.3	0.4	0.7	-0.3	-0.8	0.6
Gout (self-reported)	2.9	4.0	8.5	0.8	-2.9	1.7
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	6.0	0.3	-2.5	1.5
Medication: Amlodipine	1.2	1.8	5.1	0.2	-2.3	-0.3
Medication: Ventolin 100micrograms inhaler	5.9	7.6	8.9	-2.3	3.0	-3.0
Birth weight	0.3	0.6	1.0	-0.9	1.0	-0.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.2	-1.5	0.9	-1.0
High blood pressure (siblings)	0.6	0.9	2.0	1.4	-0.7	0.4
Forced vital capacity (FVC), Best measure	5.9	21.4	36.5	4.0	-3.4	6.0
Body fat percentage	4.1	16.1	24.5	-4.9	2.1	-4.4
Leg fat percentage (right)	4.8	17.3	26.7	-5.2	1.8	-4.7
Arm fat-free mass (right)	0.9	4.5	7.5	-2.7	-0.3	-2.4
Exposure to tobacco smoke outside home	1.7	2.3	3.1	-1.8	1.5	-1.3
Comparative body size at age 10	0.0	0.0	0.0	0.1	-0.2	-0.2
Number of full brothers	1.0	1.3	3.3	-0.3	1.8	-0.8
Worry too long after embarrassment	1.4	2.4	3.3	1.4	-1.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-0.9	0.8	-0.0
Wheeze or whistling in the chest in last year	10.1	18.0	30.5	-5.5	0.9	-4.8
Number of children fathered	0.1	0.1	0.1	-0.3	-0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	0.2	-0.4	1.3
Age at first live birth	2.8	4.9	10.1	3.2	-0.3	2.1
Pulse wave peak to peak time	0.5	0.5	0.8	-0.9	0.9	-0.3
Health satisfaction	0.3	0.4	0.7	-0.8	0.3	-0.6
Shortness of breath walking on level ground	0.9	1.1	3.2	-0.4	-1.8	0.0
Qualifications: College or University degree	5.0	15.6	22.0	4.7	-2.3	4.4
Eye problems/disorders: None of the above	1.0	1.2	3.1	-1.8	0.0	-0.7
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	0.1	-0.0
Emphysema/chronic bronchitis	5.9	6.7	8.4	-2.9	1.9	-2.8
Medication for pain relief, constipation, heartburn	2.9	4.9	10.7	3.3	1.1	1.7
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	0.3	-0.3
Medication: Blood pressure	0.4	0.8	1.3	-1.0	-0.1	-1.1
Angina (self-reported)	0.2	0.3	0.7	0.4	-0.8	0.2
Migraine (self-reported)	1.1	1.3	2.3	-1.5	-0.5	-1.2
Medication: Ibuprofen	0.1	0.1	0.2	0.0	-0.2	0.5
Medication: Allopurinol	3.5	4.7	9.7	1.1	-3.1	1.8
Medication: Omeprazole	3.3	3.9	4.9	-2.2	1.5	-2.2
Medication: Seretide 50 evohaler	2.8	3.2	7.6	-2.8	0.6	-1.3
Mean time to correctly identify matches	1.0	1.9	2.8	-1.7	-1.5	-0.9
Heart disease (mother)	0.4	0.4	0.7	-0.8	-0.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.2	5.5	-2.4	0.8	-1.9
Whole body fat mass	3.5	14.8	23.1	-4.8	1.6	-4.3
Leg fat mass (right)	3.4	13.0	21.7	-4.7	1.2	-4.0
Arm predicted mass (right)	0.9	4.5	7.5	-2.7	-0.4	-2.4
Pulse rate, automated reading	1.9	6.3	13.6	-1.7	1.5	-3.7
Alcohol intake frequency.	0.2	0.5	1.4	0.4	0.2	-1.2
Comparative height size at age 10	0.3	1.5	3.7	0.9	1.9	-0.3
Number of full sisters	0.2	0.2	0.7	0.8	0.1	-0.2
Suffer from ‘nerves’	0.1	0.1	0.2	0.1	-0.4	0.4
Overall health rating	1.2	2.5	4.0	-2.0	0.7	-1.7
Chest pain or discomfort	0.1	0.1	0.3	-0.5	-0.2	0.1
Had major operations	0.8	0.9	2.0	0.5	-1.4	0.6
Age at last live birth	1.0	1.5	3.1	1.8	-0.6	1.0
Family relationship satisfaction	0.4	0.4	0.8	-0.7	-0.9	0.2
Leg pain on walking	0.9	1.2	2.8	-1.7	0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.8	7.7	-1.4	1.3	-2.8
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.7	-0.8	0.6	-0.7
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	7.9	0.4	-1.8	2.8
Medication: Aspirin	2.0	2.6	3.8	-1.6	1.3	-2.0
Supplements: Vitamin C	0.1	0.1	0.3	0.2	-0.0	-0.6
Knee pain experienced in last month	1.5	2.3	5.1	-2.2	0.8	-1.1
Hypertension (Self-reported)	1.2	3.3	5.8	-2.0	0.3	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.8	-0.7	0.9	-0.4
Illnesses of father: Heart disease	0.9	1.3	1.7	1.3	-1.2	0.8
Illnesses of siblings: Diabetes	3.0	3.6	5.1	-2.3	1.1	-2.1
Smoking status: Previous	1.5	2.3	5.9	-0.3	-2.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	5.5	-1.6	2.4	-2.2
Whole body fat-free mass	0.3	1.6	2.6	-1.6	-0.6	-1.4
Leg fat-free mass (right)	0.3	1.4	2.9	-1.7	-0.6	-0.9
Arm fat percentage (left)	2.0	7.9	14.8	-3.9	1.1	-2.7
Average weekly red wine intake	0.9	1.3	3.8	-0.1	-2.0	0.2
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.9	-1.7	0.4	-0.3
Mood swings	0.4	0.7	1.0	-0.4	-0.9	-1.0
Loneliness, isolation	0.2	0.3	0.5	-0.7	-0.2	-0.6
Long-standing illness, disability or infirmity	3.0	4.6	6.8	-2.5	0.9	-2.6
Ever had bowel cancer screening	0.4	0.5	1.3	-1.2	-0.2	-0.3
Diabetes diagnosed by doctor	1.9	3.1	5.8	-1.2	1.4	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.7	0.4	0.9	-0.9
Friendships satisfaction	1.4	1.8	3.7	-0.1	-1.9	1.2
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.1	0.2	0.6
Commuting to job workplace: Walk	0.6	0.7	0.8	-0.9	0.6	-0.9
Eye problems/disorders: Cataract	0.8	1.0	1.6	1.3	1.0	0.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.0	1.5	-0.9	2.5
Medication for cholesterol	2.7	4.1	6.3	2.3	-0.7	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.9	-0.8	0.0
Back pain experienced in last month	0.7	1.0	1.7	-0.7	-1.3	0.9
Mineral and other dietary supplements	0.4	0.6	1.2	1.1	-0.3	0.7
Breast cancer (self-reported)	0.9	1.0	1.4	1.2	-0.6	1.2
Asthma (self-reported)	4.9	9.7	12.7	-3.6	2.0	-3.5
Osteoporosis (self-reported)	0.2	0.3	0.6	0.5	0.1	0.8
Osteoarthritis (self-reported)	0.7	0.9	1.8	-1.4	0.5	-0.8
Medication: Aspirin	1.8	2.3	3.7	-1.2	1.4	-1.9
Medication: Gliclazide	0.5	0.5	1.6	0.1	0.2	-1.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	0.6	0.1	0.6
Smoking status: Current	11.3	17.9	26.1	-4.7	2.4	-5.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.3	17.5	33.5	2.9	-3.2	5.8
Whole body water mass	0.3	1.7	2.5	-1.6	-0.8	-1.4
Leg predicted mass (right)	0.3	1.5	2.9	-1.7	-0.7	-1.0
Arm fat mass (left)	2.0	8.1	15.1	-3.9	0.7	-3.0
Number of self-reported non-cancer illnesses	7.1	12.3	19.2	-3.6	2.3	-4.4
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.2	-0.5	0.8
Miserableness	0.5	0.9	2.0	-0.3	-0.8	-1.4
Guilty feelings	1.8	2.8	4.5	1.8	-0.6	2.1
Wears glasses or contact lenses	0.3	0.3	0.6	0.8	0.1	0.6
Ever taken oral contraceptive pill	0.8	0.9	1.9	-1.4	-0.0	-1.0
Hearing aid user	1.2	1.3	1.6	-1.3	1.2	-0.9
Mother’s age at death	0.2	0.2	0.4	-0.5	0.2	0.7
Financial situation satisfaction	2.4	2.9	4.5	-0.5	-2.1	2.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.7	-0.7	-0.1
Commuting to job workplace: Public transport	0.1	0.1	0.4	-0.6	0.2	-0.2
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	0.4	-0.9	0.6
Medication: Blood pressure	3.4	6.5	10.1	-2.9	0.9	-3.2
Pain type(s) experienced in last month: Hip pain	1.7	2.2	2.9	-1.7	1.7	-1.0
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.4	-0.9	1.9	-0.9
High cholesterol (Self-reported)	0.2	0.3	0.5	0.7	0.7	0.0
Medication: Bendroflumethiazide	0.4	0.7	1.4	-0.6	0.4	-1.2
Medication: Paracetamol	0.4	0.6	1.9	-0.1	-1.4	0.2
Medication: Lisinopril	1.3	1.7	3.1	0.2	1.7	-1.4
Medication: Atorvastatin	0.2	0.2	0.5	0.7	-0.1	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	0.5	-0.2
Alcohol drinker status: Never	0.1	0.1	0.4	-0.6	0.1	-0.2
Ever smoked	1.0	1.7	3.1	-1.8	-1.4	-0.5
Basal metabolic rate	0.6	3.1	5.2	-2.3	-0.2	-2.0
Leg fat percentage (left)	5.5	19.8	30.9	-5.6	1.9	-5.0
Arm fat-free mass (left)	1.0	4.8	7.3	-2.7	-0.1	-2.7
Number of operations (self-reported)	1.0	1.5	1.8	-1.1	1.3	-1.3
Average weekly beer plus cider intake	1.5	2.1	3.2	-1.8	0.7	-1.6
Irritability	0.4	0.7	1.3	-0.9	-0.1	-1.1
Risk taking	0.5	0.8	2.0	-0.4	1.4	-0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.9	0.4	-0.6	1.4
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.7	0.2	0.8
Age started oral contraceptive pill	1.4	1.7	1.8	1.3	-1.3	1.4
Diastolic blood pressure, automated reading	5.7	17.8	31.1	-4.5	1.3	-5.6
Ever depressed for a whole week	0.4	0.5	1.0	0.1	-1.0	0.6
Unable to work because of sickness or disability	0.3	0.3	0.6	-0.2	0.8	-0.6
Commuting to job workplace: Cycle	2.5	3.0	4.8	2.2	-1.1	1.7
Myopia	1.4	2.0	4.5	1.2	2.1	0.4
Vascular/heart problems diagnosed by doctor	1.7	4.7	7.3	2.4	-0.9	2.7
Cholesterol lowering medication	1.0	1.4	2.4	0.4	1.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	6.2	7.6	10.0	-3.2	1.9	-3.0
Pain experienced in last month	3.0	5.0	10.8	3.3	-0.0	2.0
Supplements: Calcium	0.1	0.1	0.2	0.1	0.4	-0.0
Basal cell carcinoma (self-reported)	1.0	1.2	1.9	1.4	1.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	0.1	-0.7	1.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	0.6	0.3	-0.5
Heart disease (siblings)	0.2	0.2	0.3	-0.6	-0.4	-0.3
Alcohol drinker status: Previous	1.0	1.1	2.6	-0.7	0.5	-1.6
Pack years of smoking	3.2	4.7	6.6	-2.4	1.3	-2.6
Impedance of whole body	1.0	4.9	11.3	0.7	3.4	-1.7
Leg fat mass (left)	3.6	14.0	23.3	-4.8	1.3	-4.1
Arm predicted mass (left)	0.9	4.7	7.3	-2.6	-0.0	-2.7