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chr1:20,216,860-22,807,171

Best TWAS P=1.22e-14 · Best GWAS P=7.93e-13 conditioned to 0.157

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Heart Atrial Appendage	CDA	0.20	0.03	enet	11	0.03	1.4e-02	-5.7	-7.7	1.2e-14	0.03	0.09	0.05	TRUE
11	GTEx	Cells Transformed fibroblasts	RP5-930J4.4	0.05	0.00	lasso	2	0.00	2.4e-01	-6.7	7.3	2.0e-13	-0.83	0.05	0.70	TRUE
1	CommonMind	Brain Pre-frontal Cortex	USP48	0.06	0.00	blup	535	0.02	7.3e-04	-1.9	-5.4	5.3e-08	0.01	0.14	0.03	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDA	0.17	0.11	blup	116	0.14	1.1e-15	-5.9	-7.3	2.4e-13	0.00	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDA	0.24	0.07	enet	22	0.21	3.8e-21	-6.9	-7.2	6.6e-13	-0.03	0.00	1.00	FALSE
6	GTEx	Brain Cerebellum	HP1BP3	0.27	0.07	lasso	4	0.03	3.8e-02	-6.1	-7.1	1.2e-12	0.79	0.05	0.39	FALSE
14	GTEx	Lung	EIF4G3	0.08	0.03	lasso	3	0.02	5.7e-03	-7.2	7.1	1.2e-12	-1.00	0.03	0.96	FALSE
23	METSIM	Adipose	CDA	0.11	0.09	lasso	11	0.11	2.5e-16	-6.9	-7.0	2.7e-12	-0.04	0.06	0.94	FALSE
15	GTEx	Muscle Skeletal	EIF4G3	0.09	0.05	lasso	6	0.03	2.9e-04	-7.2	6.9	4.9e-12	-0.99	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	HP1BP3	0.01	0.00	blup	52	0.00	4.2e-02	-7.1	-6.9	5.8e-12	0.91	0.01	0.80	FALSE
2	GTEx	Adipose Subcutaneous	CDA	0.24	0.13	lasso	6	0.21	3.0e-17	-5.9	-6.7	1.6e-11	0.03	0.98	0.02	FALSE
3	GTEx	Adipose Visceral Omentum	CDA	0.30	0.02	enet	38	0.09	2.3e-05	3.1	-6.5	8.4e-11	0.17	0.17	0.09	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDA	0.16	0.04	blup	116	0.14	1.1e-27	3.1	-6.4	1.3e-10	0.00	0.03	0.97	FALSE
19	GTEx	Testis	CDA	0.35	0.19	lasso	8	0.20	2.2e-09	-5.4	-6.2	5.0e-10	0.02	0.96	0.01	FALSE
20	GTEx	Thyroid	CDA	0.24	0.12	lasso	6	0.26	1.4e-19	-3.7	-6.2	5.1e-10	0.00	1.00	0.00	FALSE
7	GTEx	Breast Mammary Tissue	CDA	0.25	0.12	lasso	4	0.20	2.6e-10	-5.7	-6.2	7.4e-10	-0.02	0.97	0.01	FALSE
8	GTEx	Breast Mammary Tissue (Male)	CDA	0.23	0.00	enet	19	-0.01	7.8e-01	4.6	-6.1	8.3e-10	0.49	0.06	0.18	FALSE
9	GTEx	Breast Mammary Tissue (Female)	CDA	0.25	0.14	lasso	3	0.21	7.3e-07	-5.7	-6.1	9.0e-10	-0.02	0.24	0.04	FALSE
4	GTEx	Adrenal Gland	CDA	0.24	0.04	lasso	8	0.05	5.6e-03	-5.7	-6.1	1.2e-09	0.04	0.21	0.04	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SH2D5	0.04	0.04	blup	56	0.02	2.2e-03	-7.0	6.1	1.2e-09	-0.85	0.01	0.98	FALSE
32	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDA	0.11	0.03	lasso	3	0.05	5.0e-03	-5.5	-6.0	2.5e-09	0.03	0.03	0.56	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	CDA	0.16	0.12	enet	17	0.10	2.6e-06	-5.9	-5.9	3.4e-09	-0.03	0.02	0.98	FALSE
18	GTEx	Small Intestine Terminal Ileum	KIF17	0.24	0.04	lasso	7	0.02	1.3e-01	4.2	5.9	4.5e-09	-0.56	0.07	0.45	FALSE
10	GTEx	Cells Transformed fibroblasts	CDA	0.30	0.09	lasso	12	0.17	5.3e-13	3.5	-5.8	7.3e-09	-0.06	1.00	0.00	FALSE
16	GTEx	Muscle Skeletal	CDA	0.17	0.12	lasso	7	0.15	1.3e-14	3.1	-5.8	8.6e-09	-0.01	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDA	0.07	0.04	blup	115	0.08	3.0e-05	-5.9	-5.6	1.8e-08	0.05	0.03	0.86	FALSE
12	GTEx	Heart Atrial Appendage	EIF4G3	0.23	0.06	lasso	6	0.03	1.1e-02	5.2	5.6	1.9e-08	-0.73	0.05	0.88	FALSE
22	GTEx	Whole Blood	RP5-930J4.4	0.07	0.09	lasso	5	0.09	1.0e-08	5.0	5.6	2.1e-08	-0.76	0.60	0.40	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	CDA	0.27	0.09	enet	30	0.20	6.8e-19	-5.9	-5.6	2.5e-08	-0.01	0.00	1.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	HP1BP3	0.02	0.02	blup	467	0.02	4.0e-03	-6.6	-5.5	3.1e-08	0.91	0.06	0.86	FALSE
5	GTEx	Artery Tibial	CDA	0.18	0.04	lasso	7	0.09	8.2e-08	3.4	-5.4	5.6e-08	0.00	0.98	0.00	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDA	0.23	0.18	enet	23	0.24	2.3e-26	-3.7	-5.4	6.3e-08	0.00	1.00	0.00	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CDA	0.14	0.05	enet	6	0.07	4.2e-06	4.5	5.3	9.8e-08	-0.08	0.97	0.00	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	CDA	0.07	0.01	blup	116	0.02	1.8e-02	4.4	-5.3	1.1e-07	0.03	0.04	0.19	FALSE
21	GTEx	Whole Blood	HP1BP3	0.04	0.04	lasso	4	0.02	6.3e-03	5.0	5.3	1.2e-07	-0.70	0.32	0.58	FALSE