Best TWAS P=1.22e-14 · Best GWAS P=7.93e-13 conditioned to 0.157
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | USP48 | 0.06 | 0.00 | blup | 535 | 0.02 | 7.3e-04 | -1.9 | -5.4 | 5.3e-08 | 0.01 | 0.14 | 0.03 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | CDA | 0.24 | 0.13 | lasso | 6 | 0.21 | 3.0e-17 | -5.9 | -6.7 | 1.6e-11 | 0.03 | 0.98 | 0.02 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CDA | 0.30 | 0.02 | enet | 38 | 0.09 | 2.3e-05 | 3.1 | -6.5 | 8.4e-11 | 0.17 | 0.17 | 0.09 | FALSE |
| 4 | GTEx | Adrenal Gland | CDA | 0.24 | 0.04 | lasso | 8 | 0.05 | 5.6e-03 | -5.7 | -6.1 | 1.2e-09 | 0.04 | 0.21 | 0.04 | FALSE |
| 5 | GTEx | Artery Tibial | CDA | 0.18 | 0.04 | lasso | 7 | 0.09 | 8.2e-08 | 3.4 | -5.4 | 5.6e-08 | 0.00 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Brain Cerebellum | HP1BP3 | 0.27 | 0.07 | lasso | 4 | 0.03 | 3.8e-02 | -6.1 | -7.1 | 1.2e-12 | 0.79 | 0.05 | 0.39 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | CDA | 0.25 | 0.12 | lasso | 4 | 0.20 | 2.6e-10 | -5.7 | -6.2 | 7.4e-10 | -0.02 | 0.97 | 0.01 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | CDA | 0.23 | 0.00 | enet | 19 | -0.01 | 7.8e-01 | 4.6 | -6.1 | 8.3e-10 | 0.49 | 0.06 | 0.18 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | CDA | 0.25 | 0.14 | lasso | 3 | 0.21 | 7.3e-07 | -5.7 | -6.1 | 9.0e-10 | -0.02 | 0.24 | 0.04 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CDA | 0.30 | 0.09 | lasso | 12 | 0.17 | 5.3e-13 | 3.5 | -5.8 | 7.3e-09 | -0.06 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | RP5-930J4.4 | 0.05 | 0.00 | lasso | 2 | 0.00 | 2.4e-01 | -6.7 | 7.3 | 2.0e-13 | -0.83 | 0.05 | 0.70 | TRUE |
| 12 | GTEx | Heart Atrial Appendage | EIF4G3 | 0.23 | 0.06 | lasso | 6 | 0.03 | 1.1e-02 | 5.2 | 5.6 | 1.9e-08 | -0.73 | 0.05 | 0.88 | FALSE |
| 13 | GTEx | Heart Atrial Appendage | CDA | 0.20 | 0.03 | enet | 11 | 0.03 | 1.4e-02 | -5.7 | -7.7 | 1.2e-14 | 0.03 | 0.09 | 0.05 | TRUE |
| 14 | GTEx | Lung | EIF4G3 | 0.08 | 0.03 | lasso | 3 | 0.02 | 5.7e-03 | -7.2 | 7.1 | 1.2e-12 | -1.00 | 0.03 | 0.96 | FALSE |
| 15 | GTEx | Muscle Skeletal | EIF4G3 | 0.09 | 0.05 | lasso | 6 | 0.03 | 2.9e-04 | -7.2 | 6.9 | 4.9e-12 | -0.99 | 0.02 | 0.98 | FALSE |
| 16 | GTEx | Muscle Skeletal | CDA | 0.17 | 0.12 | lasso | 7 | 0.15 | 1.3e-14 | 3.1 | -5.8 | 8.6e-09 | -0.01 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | CDA | 0.14 | 0.05 | enet | 6 | 0.07 | 4.2e-06 | 4.5 | 5.3 | 9.8e-08 | -0.08 | 0.97 | 0.00 | FALSE |
| 18 | GTEx | Small Intestine Terminal Ileum | KIF17 | 0.24 | 0.04 | lasso | 7 | 0.02 | 1.3e-01 | 4.2 | 5.9 | 4.5e-09 | -0.56 | 0.07 | 0.45 | FALSE |
| 19 | GTEx | Testis | CDA | 0.35 | 0.19 | lasso | 8 | 0.20 | 2.2e-09 | -5.4 | -6.2 | 5.0e-10 | 0.02 | 0.96 | 0.01 | FALSE |
| 20 | GTEx | Thyroid | CDA | 0.24 | 0.12 | lasso | 6 | 0.26 | 1.4e-19 | -3.7 | -6.2 | 5.1e-10 | 0.00 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Whole Blood | HP1BP3 | 0.04 | 0.04 | lasso | 4 | 0.02 | 6.3e-03 | 5.0 | 5.3 | 1.2e-07 | -0.70 | 0.32 | 0.58 | FALSE |
| 22 | GTEx | Whole Blood | RP5-930J4.4 | 0.07 | 0.09 | lasso | 5 | 0.09 | 1.0e-08 | 5.0 | 5.6 | 2.1e-08 | -0.76 | 0.60 | 0.40 | FALSE |
| 23 | METSIM | Adipose | CDA | 0.11 | 0.09 | lasso | 11 | 0.11 | 2.5e-16 | -6.9 | -7.0 | 2.7e-12 | -0.04 | 0.06 | 0.94 | FALSE |
| 24 | ROSMAP | Brain Pre-frontal Cortex | HP1BP3 | 0.02 | 0.02 | blup | 467 | 0.02 | 4.0e-03 | -6.6 | -5.5 | 3.1e-08 | 0.91 | 0.06 | 0.86 | FALSE |
| 25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDA | 0.16 | 0.04 | blup | 116 | 0.14 | 1.1e-27 | 3.1 | -6.4 | 1.3e-10 | 0.00 | 0.03 | 0.97 | FALSE |
| 26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HP1BP3 | 0.01 | 0.00 | blup | 52 | 0.00 | 4.2e-02 | -7.1 | -6.9 | 5.8e-12 | 0.91 | 0.01 | 0.80 | FALSE |
| 27 | The Cancer Genome Atlas | Colon Adenocarcinoma | CDA | 0.16 | 0.12 | enet | 17 | 0.10 | 2.6e-06 | -5.9 | -5.9 | 3.4e-09 | -0.03 | 0.02 | 0.98 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDA | 0.17 | 0.11 | blup | 116 | 0.14 | 1.1e-15 | -5.9 | -7.3 | 2.4e-13 | 0.00 | 0.01 | 0.99 | FALSE |
| 29 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SH2D5 | 0.04 | 0.04 | blup | 56 | 0.02 | 2.2e-03 | -7.0 | 6.1 | 1.2e-09 | -0.85 | 0.01 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CDA | 0.07 | 0.04 | blup | 115 | 0.08 | 3.0e-05 | -5.9 | -5.6 | 1.8e-08 | 0.05 | 0.03 | 0.86 | FALSE |
| 31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDA | 0.23 | 0.18 | enet | 23 | 0.24 | 2.3e-26 | -3.7 | -5.4 | 6.3e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 32 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CDA | 0.11 | 0.03 | lasso | 3 | 0.05 | 5.0e-03 | -5.5 | -6.0 | 2.5e-09 | 0.03 | 0.03 | 0.56 | FALSE |
| 33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDA | 0.24 | 0.07 | enet | 22 | 0.21 | 3.8e-21 | -6.9 | -7.2 | 6.6e-13 | -0.03 | 0.00 | 1.00 | FALSE |
| 34 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CDA | 0.07 | 0.01 | blup | 116 | 0.02 | 1.8e-02 | 4.4 | -5.3 | 1.1e-07 | 0.03 | 0.04 | 0.19 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | CDA | 0.27 | 0.09 | enet | 30 | 0.20 | 6.8e-19 | -5.9 | -5.6 | 2.5e-08 | -0.01 | 0.00 | 1.00 | FALSE |