Hub : Genes

KIF17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.247	0.0440	0.0e+00	0.194	0.206	0.171	0.208	0.205	4.5e-23	1.6e-24	2.7e-20	8.2e-25	2.1e-24
2	GTEx	Brain Caudate basal ganglia	0.219	0.0990	7.9e-03	0.182	NA	0.058	NA	0.187	6.4e-06	NA	9.5e-03	NA	4.7e-06
3	GTEx	Small Intestine Terminal Ileum	0.240	0.0940	2.4e-03	0.036	NA	-0.006	NA	0.017	5.6e-02	NA	4.5e-01	NA	1.3e-01
4	GTEx	Testis	0.189	0.0670	4.9e-05	0.233	NA	0.129	NA	0.234	1.0e-10	NA	2.5e-06	NA	9.7e-11
5	ROSMAP	Brain Pre-frontal Cortex	0.151	0.0331	6.7e-14	0.114	0.123	0.164	0.130	0.146	2.0e-14	1.6e-15	1.7e-20	2.1e-16	2.5e-18
6	TCGA	Esophageal Carcinoma	0.156	0.0790	9.4e-03	0.066	0.067	0.031	NA	0.049	3.8e-03	3.6e-03	3.7e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.2	0.8	-0.1	-0.2	-0.9	-0.1	-0.4	0.4
Bipolar Disorder or Schizophrenia	0.9	2.2	3.6	-1.7	-1.9	1.1	-1.9	-1.5	-0.2
Depressed Affect (Nagel 2018)	2.7	5.8	9.4	-3.1	-2.6	2.6	-2.6	-2.1	-0.4
Depression (Nagel 2018)	1.8	2.7	7.8	-2.8	-1.6	1.5	-1.7	-0.7	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.4	-0.9	-1.6	0.5	-1.5	-0.9	-1.1
Neuroticism (Nagel 2018)	4.8	11.3	17.9	-4.2	-3.5	3.4	-3.6	-3.5	-1.3
Schizophrenia (2018)	1.8	3.8	5.4	-2.0	-2.3	2.2	-2.3	-1.6	-0.7
Schizophrenia vs Biploar Disorder	5.0	6.6	10.6	-3.3	-3.1	2.4	-3.2	-1.5	-0.5
Worry (Nagel 2018)	3.6	7.6	12.5	-3.5	-2.9	2.2	-3.0	-3.3	-0.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.0	-1.1	0.7	-1.1	-0.5	0.4
Alzheimer’s Disease (in father)	0.0	0.0	0.0	-0.2	0.1	-0.0	0.0	0.1	-0.2
Alzheimer’s Disease (including proxy)	1.6	2.3	3.6	-1.8	-1.9	1.4	-1.9	-1.2	-0.1
Crohns Disease (2017)	0.1	0.2	0.6	0.7	0.2	0.1	0.3	0.3	0.8
Irritable Bowel Disease (IBD)	0.1	0.1	0.6	0.1	-0.2	0.8	-0.2	-0.0	0.2
Ulcerative Colitis (UC)	0.7	1.4	3.8	-1.0	-1.2	1.9	-1.2	-0.5	-0.5
Major Depression (MDD)	1.8	2.2	5.1	-2.3	-1.4	1.4	-1.4	-1.3	-0.4
Reaction Time	0.5	0.9	4.7	0.4	0.0	-0.5	0.1	0.5	2.2
Verbal and Numeric Reasoning (VNR)	1.3	3.2	4.9	-1.3	-2.2	1.4	-2.2	-1.9	-1.6
Breast Cancer	0.4	1.0	2.7	-1.1	-0.8	0.1	-0.8	-1.0	-1.6
Ovarian Cancer	1.2	1.5	2.8	1.5	1.7	-0.1	1.7	0.3	-1.2
Prostate Cancer	0.4	0.6	1.3	-0.7	-1.2	-0.1	-1.1	-0.5	-0.5
Age at First Birth	0.8	1.1	2.1	1.1	1.0	-1.0	1.1	0.6	1.4
Bipolar Disorder (2011)	0.3	0.3	0.5	-0.5	-0.6	0.5	-0.6	0.2	0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.4	0.0	1.0	0.0	-0.9	0.0
Coronary Artery Disease (CAD)	1.8	2.1	6.2	-1.4	-1.0	1.5	-1.0	-2.5	-0.7
Crohns Disease (2012)	0.9	1.5	6.5	0.7	0.5	1.0	0.4	0.7	2.5
Mean Putamen Volume	0.5	0.5	1.0	-0.8	-1.0	0.1	-1.0	0.4	0.8
Fasting Glucose	0.7	0.8	2.3	0.2	0.5	-1.0	0.4	-1.1	-1.5
HbA1C	0.4	0.4	1.2	-0.4	-0.4	0.4	-0.4	-0.9	-1.1
HDL Cholesterol	0.9	1.5	4.6	1.0	0.6	-0.8	0.6	2.1	1.3
LDL Cholesterol	1.6	2.5	4.2	-1.3	-1.4	1.9	-1.4	-2.0	-1.2
Lupus	1.4	2.1	3.0	1.7	1.6	-0.8	1.6	1.6	1.2
Neuroticism (2016)	2.8	4.0	8.2	-2.9	-2.4	1.0	-2.4	-1.8	-0.2
Primary Biliary Cirrhosis	0.7	1.0	2.3	-1.5	-0.9	0.8	-0.9	0.5	0.9
Rheumatoid Arthritis	0.2	0.3	0.4	-0.6	-0.4	0.4	-0.5	0.7	-0.5
Schizophrenia (2014)	1.2	2.6	3.8	-1.7	-1.9	1.9	-1.9	-1.2	-0.5
Triglycerides	0.3	0.5	1.9	-0.6	0.1	0.7	-0.0	-0.6	-1.4
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.8	-0.9	-0.8	0.9	-0.9	-1.7	-0.3
Ulcerative Colitis	0.2	0.3	1.1	0.0	0.1	0.3	0.0	0.8	1.0
Blood Eosinophil Count	1.6	12.2	26.9	-4.0	-3.1	5.2	-3.2	-2.9	-1.3
Blood Platelet Count	0.7	8.2	17.2	-3.9	-2.2	2.5	-2.3	0.4	-4.2
Blood Red Count	1.5	14.9	34.5	-4.2	-3.7	5.9	-4.0	-1.9	-2.0
Blood White Count	0.3	2.5	9.5	-1.5	0.0	1.8	-0.2	0.2	-3.1
Heel T-Score	0.4	3.3	5.6	2.4	1.6	-0.2	1.7	2.0	2.1
BMI	0.2	1.1	2.9	-0.9	-1.1	1.7	-1.0	-0.1	-0.5
Height	4.7	90.9	148.8	9.8	9.7	-12.2	9.9	7.0	7.5
Waist Hip Ratio (WHR)	1.2	5.2	8.8	-3.0	-2.1	2.5	-2.3	-2.5	-0.9
Systolic Blood Pressure	1.3	6.4	13.4	-3.7	-3.0	1.8	-3.2	-1.7	-0.2
Smoking Status	0.8	2.0	4.0	1.3	1.5	-2.0	1.6	0.6	-0.8
Allergy or Eczema	0.1	0.4	1.0	0.4	0.5	0.5	0.6	1.0	-0.4
Cardiovascular Disease	3.3	10.9	16.3	-3.9	-4.0	2.6	-4.0	-3.1	-1.0
Hypothyroidism (self reported)	0.4	1.0	2.4	-1.1	-0.8	0.9	-0.7	-0.6	1.6
Respiratory disease	1.2	2.7	5.0	1.7	2.2	-0.4	2.2	1.8	0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.2	4.7	0.3	0.8	-0.5	0.7	-1.0	-2.2
Lung FEV1/FVC ratio	0.9	4.4	8.4	-2.0	-2.2	2.9	-2.2	-2.1	0.0
Lung FVC	1.3	6.8	12.3	-2.6	-2.5	2.9	-2.6	-1.0	-3.5
Neuroticism	4.5	11.0	17.3	-4.2	-3.5	2.9	-3.6	-3.8	-1.0
Chronotype (morning person)	3.6	8.3	17.7	3.3	2.1	-3.3	2.3	4.2	0.6
Hair Pigment	0.1	1.5	2.6	1.5	1.6	-0.5	1.6	0.5	0.9
Tanning	0.5	6.5	10.4	3.2	3.2	-2.4	3.1	1.6	-0.2
Hand grip strength (left)	1.1	2.9	5.9	2.0	1.6	-2.4	1.6	-0.3	1.5
Number of treatments/medications taken	1.2	2.1	3.6	-1.6	-1.9	1.1	-1.9	-0.8	-1.0
Average weekly spirits intake	0.5	0.6	1.0	-1.0	-0.9	0.7	-1.0	0.5	-0.3
Sensitivity / hurt feelings	2.3	3.9	5.7	-2.4	-2.0	1.7	-2.0	-2.0	-1.7
Frequency of depressed mood in last 2 weeks	3.3	4.6	9.2	-3.0	-2.4	1.6	-2.5	-1.9	-0.5
Hearing difficulty/problems: Yes	0.3	0.4	0.7	-0.3	-0.8	0.8	-0.8	-0.5	0.3
Relative age of first facial hair	0.0	0.0	0.1	-0.0	0.0	-0.1	0.1	0.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.2	-1.1	-0.9	1.0	-1.0	-0.8	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.9	-0.5	-0.5	-0.2	-0.6	0.8	-1.4
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-0.9	-0.1	0.5	-0.2	-1.1	-0.9
Systolic blood pressure, automated reading	1.0	2.9	4.6	-1.9	-1.8	2.1	-1.9	-0.9	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	-1.2	-0.3	1.0	-0.4	-0.1	0.0
Angina	0.5	0.7	2.5	-0.3	-0.2	0.6	-0.2	-1.0	-1.6
Medication for hormone replacement therapy	0.5	0.5	1.5	0.4	-0.7	0.5	-0.7	-1.2	-0.7
Vitamin and mineral supplements	0.1	0.1	0.4	0.1	0.6	0.1	0.6	-0.2	-0.3
Supplements: Zinc	0.2	0.2	0.6	-0.7	0.2	-0.8	0.1	0.4	-0.3
Medication: Co-codamol	1.4	1.6	2.9	-1.4	-1.7	0.8	-1.6	0.7	-1.1
Medication: Metformin	1.9	2.7	4.3	1.8	2.0	-0.8	1.9	-0.7	-2.1
Diabetes (father)	0.9	1.1	3.3	-1.4	-0.7	0.3	-0.7	-0.5	-1.8
Diabetes (mother)	0.2	0.3	1.3	0.2	-0.0	-0.4	-0.0	1.1	-0.2
Severe depression (siblings)	1.3	1.5	3.3	-1.7	-0.9	1.8	-1.0	-1.0	-0.3
Pack years adult smoking proportion	0.2	0.2	0.3	0.6	0.5	-0.5	0.6	-0.5	-0.2
Impedance of leg (right)	0.3	1.4	2.1	0.6	1.4	-1.1	1.3	1.4	-0.8
Leg fat-free mass (left)	0.5	2.8	6.5	1.6	1.3	-2.0	1.4	0.4	2.5
Trunk fat percentage	0.4	1.7	4.7	-1.2	-1.2	2.2	-1.2	-0.7	-0.7
Hand grip strength (right)	1.5	4.0	6.2	2.4	2.0	-2.5	2.0	0.6	1.9
Townsend deprivation index at recruitment	1.0	1.4	5.0	-0.5	-0.9	0.3	-0.8	-2.2	-1.2
Current tobacco smoking	0.3	0.5	1.7	-0.5	0.2	-0.5	0.2	-0.8	-1.3
Average weekly fortified wine intake	0.3	0.4	1.5	-0.1	-0.0	0.7	-0.1	-0.4	-1.2
Maternal smoking around birth	0.2	0.4	1.8	-0.1	0.1	-1.3	0.1	-0.5	0.3
Fed-up feelings	4.6	8.3	13.6	-3.7	-3.5	2.4	-3.5	-2.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.5	-2.4	-1.3	2.2	-1.4	-1.1	-0.7
Relative age voice broke	1.0	1.6	4.2	0.1	-0.5	1.6	-0.5	-1.5	2.0
Taking other prescription medications	0.5	0.8	1.3	-1.1	-1.0	1.1	-1.0	-0.3	-0.5
Age when periods started (menarche)	0.9	2.1	4.5	2.1	1.8	-1.0	1.9	0.7	-0.2
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	6.2	-2.3	-2.4	1.5	-2.5	-2.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	6.1	-0.1	-1.0	0.4	-0.9	-1.1	2.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	-1.0	-0.8	-0.4	-0.8	-0.3	1.1
Qualifications: CSEs or equivalent	0.7	0.9	2.0	-1.4	-1.0	0.5	-1.1	-1.1	0.1
Serious illness, injury or assault to yourself	0.1	0.2	0.7	0.3	-0.2	0.1	-0.2	-0.9	-0.3
High blood pressure	2.6	7.4	11.0	-2.9	-3.3	2.7	-3.3	-2.4	-1.0
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.2	0.0	0.8	0.1	0.4	-0.6
Multivitamins +/- minerals	0.2	0.3	0.4	-0.7	-0.6	0.5	-0.6	-0.0	-0.3
Stomach or abdominal pain in last month	2.1	2.6	5.2	-1.5	-1.7	2.3	-1.7	-1.4	0.6
Supplements: Glucosamine	0.4	0.5	0.9	1.0	0.5	-0.9	0.5	-0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	6.8	-1.5	-1.3	2.6	-1.4	-0.2	0.5
Medication: Atenolol	0.3	0.3	1.1	-0.4	-0.5	0.6	-0.5	-1.0	-0.1
Medication: Levothyroxine sodium	0.3	0.5	1.8	-0.3	-0.4	1.4	-0.3	-0.4	0.7
Sitting height	2.1	15.2	28.4	2.8	3.6	-5.3	3.6	2.6	4.7
Chronic bronchitis/emphysema (father)	0.4	0.4	1.1	-0.4	-1.0	0.6	-1.0	-0.2	0.2
High blood pressure (mother)	1.3	1.8	3.1	-1.0	-1.3	1.8	-1.2	-1.6	0.9
Body mass index (BMI)	0.9	3.7	9.5	-1.9	-1.9	3.1	-1.9	-0.8	-1.1
Impedance of leg (left)	0.4	1.8	3.5	0.7	1.5	-1.6	1.4	1.9	-0.6
Leg predicted mass (left)	0.6	3.1	6.8	1.7	1.4	-2.1	1.6	0.5	2.6
Trunk fat mass	0.1	0.3	1.1	-0.4	-0.4	1.1	-0.3	0.1	0.2
Waist circumference	0.7	2.4	5.2	-1.8	-1.7	2.3	-1.6	-0.8	-0.5
Number of incorrect matches in round	3.7	6.2	11.1	-3.3	-2.8	2.6	-2.8	-1.4	-1.4
Past tobacco smoking	0.1	0.2	0.4	-0.6	-0.6	0.5	-0.6	-0.1	-0.3
Alcohol usually taken with meals	0.1	0.2	0.7	0.2	0.0	-0.8	0.1	-0.6	-0.5
Nervous feelings	2.8	5.2	7.5	-2.7	-2.6	1.6	-2.7	-2.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	4.2	-2.0	-1.1	0.5	-1.2	-0.7	0.4
Hearing difficulty/problems with background noise	0.5	0.9	4.7	0.6	-0.0	0.2	0.0	-0.3	2.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.7	0.6	-0.2	0.5	0.5	-0.2
Had menopause	1.4	1.7	5.4	1.1	1.2	-2.3	1.2	0.1	-0.9
Had other major operations	2.3	2.7	4.4	1.7	1.6	-2.0	1.6	0.3	2.1
Forced vital capacity (FVC)	0.8	3.0	9.7	0.7	1.6	-3.1	1.6	1.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	6.0	0.7	-0.1	0.1	-0.0	-0.3	2.5
Ever unenthusiastic/disinterested for a whole week	5.1	6.2	10.6	-3.2	-2.8	1.5	-2.8	-1.6	-2.5
Qualifications: None of the above	0.4	0.8	1.3	-0.9	-1.1	1.1	-1.1	-0.3	0.6
Financial difficulties in last 2 years	0.6	0.8	2.8	-0.1	0.8	-1.7	0.8	0.7	0.2
Mouth/teeth dental problems	0.2	0.3	0.6	-0.1	-0.5	0.3	-0.5	-0.7	0.8
Heart attack	1.3	1.6	4.6	-1.2	-1.2	0.8	-1.2	-2.1	-0.6
Allergy	0.1	0.3	1.0	0.2	-0.5	-0.7	-0.5	-1.0	-0.2
Pain all over the body in last month	0.4	0.5	1.3	-0.2	-0.6	0.5	-0.7	-0.6	1.1
Diabetes (self-reported)	0.7	1.2	4.5	0.5	0.7	0.4	0.6	-1.1	-2.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.8	1.3	0.9	-0.4	0.9	0.8	0.3
Medication: Ramipril	1.0	1.3	3.2	-1.8	-1.1	0.8	-1.1	-0.5	-1.2
Medication: Simvastatin	2.1	3.2	4.1	-1.6	-2.0	1.8	-2.0	-1.9	-1.0
Fluid intelligence score	0.3	0.6	2.5	-0.2	-0.5	0.4	-0.4	0.5	-1.6
Illnesses of siblings	2.4	3.3	4.6	1.8	2.1	-2.0	2.1	1.6	0.9
Neuroticism score	6.5	13.7	20.6	-4.5	-3.8	3.3	-3.9	-4.3	-1.5
Weight	0.2	1.0	2.7	0.7	0.7	-0.7	0.9	1.0	1.6
Impedance of arm (right)	0.1	0.6	0.9	0.8	0.9	-0.4	0.9	-0.4	1.0
Arm fat percentage (right)	0.9	3.7	11.5	-1.6	-1.7	3.4	-1.6	-1.3	-0.9
Trunk fat-free mass	1.9	11.0	15.0	3.2	3.1	-3.9	3.2	2.7	3.7
Hip circumference	0.0	0.2	0.8	0.2	0.3	-0.1	0.4	0.9	0.4
Time employed in main current job	2.0	2.3	3.8	-1.6	-2.0	1.3	-1.9	-1.1	-0.8
Alcohol intake versus 10 years previously	0.9	1.3	5.7	-0.4	-0.5	1.2	-0.5	-0.4	-2.4
Father’s age at death	1.2	1.6	2.9	1.7	1.5	-0.2	1.6	1.3	0.2
Worrier / anxious feelings	4.0	7.5	13.8	-3.7	-2.9	2.1	-2.9	-2.9	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	6.5	-2.5	-2.2	2.2	-2.2	-1.4	-0.8
Falls in the last year	0.7	1.0	2.8	0.2	-0.3	-0.9	-0.3	1.5	1.7
Hair/balding pattern: Pattern 3	1.0	1.4	3.0	-1.7	-1.2	0.8	-1.2	-1.1	-1.0
Number of live births	0.1	0.2	0.6	-0.4	-0.1	0.4	-0.1	0.5	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	2.2	-0.4	0.4	-1.5	0.3	-0.0	0.3
Pulse rate	0.6	1.0	1.2	0.7	1.1	-0.9	1.0	1.1	-1.1
Happiness	1.0	1.2	3.1	-1.4	-0.7	1.8	-0.8	0.1	-1.1
Noisy workplace	0.1	0.1	0.5	0.5	0.0	-0.1	0.0	-0.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.1	1.1	0.8	0.9	0.8	0.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.7	0.8	1.3	-0.9	1.2	1.3	-0.7
Mouth/teeth dental problems: Dentures	1.2	2.0	2.8	1.3	1.7	-1.5	1.7	1.4	0.5
Asthma	1.8	3.6	6.2	1.7	2.5	-0.7	2.5	2.0	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-0.9	-1.1	0.7	-1.1	-0.1	0.4
Medication: Cholesterol lowering	1.0	1.6	3.0	-1.0	-1.3	0.3	-1.2	-1.5	-1.7
Depression (self-reported)	0.6	0.7	3.2	-0.6	-0.4	-0.1	-0.4	0.0	-1.8
Medication: Lansoprazole	0.1	0.1	0.3	0.6	-0.0	0.5	-0.0	0.0	0.5
Prospective memory result	0.2	0.3	0.8	-0.2	-0.3	-0.8	-0.2	-0.1	0.9
Lung cancer (father)	1.3	1.5	2.2	1.4	1.1	-1.5	1.2	1.3	-0.7
Illnesses of mother	1.5	1.8	3.5	0.7	1.4	-1.8	1.4	1.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	2.1	-0.1	0.6	-1.4	0.5	0.4	0.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	0.5	0.6	-0.7	0.6	1.0	-0.9
Impedance of arm (left)	0.0	0.1	0.4	0.2	0.4	-0.2	0.3	-0.6	0.4
Arm fat mass (right)	0.2	0.8	3.1	-0.8	-0.7	1.8	-0.6	-0.4	-0.1
Trunk predicted mass	1.9	10.8	14.6	3.2	3.0	-3.8	3.1	2.7	3.7
Standing height	3.9	38.5	71.7	5.7	5.9	-8.5	6.0	4.4	6.0
Length of working week for main job	0.5	0.5	1.3	0.8	0.2	-1.2	0.3	0.9	0.3
Exposure to tobacco smoke at home	1.0	1.1	1.6	-0.7	-1.2	1.3	-1.2	-0.6	1.1
Breastfed as a baby	1.0	1.2	1.5	-1.2	-1.2	0.4	-1.2	-1.2	-1.2
Tense / ‘highly strung’	1.5	2.5	5.9	-1.9	-1.4	1.3	-1.4	-2.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.4	-1.9	-1.4	0.4	-1.4	-1.4	-1.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.3	-0.1	0.3	-0.1	0.0	-0.5
Birth weight of first child	0.2	0.3	1.0	-0.4	-0.6	-0.2	-0.5	0.2	-1.0
Peak expiratory flow (PEF)	0.3	0.6	1.6	-1.2	-0.4	0.2	-0.5	-1.3	-0.4
Pulse wave reflection index	0.3	0.4	0.9	0.2	0.8	-0.0	0.8	0.9	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	-1.3	-0.9	-1.0	-0.9	-0.0	-0.7
Loud music exposure frequency	0.8	0.9	2.0	-0.1	0.7	-1.4	0.6	0.8	-1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.9	0.9	0.9	-0.6	0.9	0.9	-0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	-0.8	0.0	0.9	-0.1	0.5	-1.5
Blood clot in the leg (DVT)	2.5	3.2	5.1	-1.5	-2.3	1.2	-2.2	-2.0	-1.2
Medication: Paracetamol	2.1	3.5	6.0	-1.9	-2.4	1.8	-2.4	0.6	1.3
Headache pain in last month	1.5	2.5	5.2	-1.6	-1.6	2.3	-1.6	-0.9	-1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	0.6	1.1	0.0	1.1	1.2	0.5
Glaucoma (self-reported)	0.4	0.5	1.8	0.4	0.5	0.1	0.5	1.3	0.7
Gout (self-reported)	0.6	0.8	4.5	0.4	-0.1	0.3	-0.1	0.1	2.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	4.0	-1.0	-1.1	2.0	-1.0	-0.9	1.0
Medication: Amlodipine	1.3	1.8	2.6	-1.1	-1.6	1.5	-1.6	-1.4	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	0.2	0.6	-0.2	0.6	1.2	0.7
Birth weight	0.1	0.2	0.8	0.2	-0.1	0.9	-0.1	0.4	0.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.1	1.1	1.3	0.4	1.2	2.0	0.5
High blood pressure (siblings)	0.5	0.7	1.9	-0.8	-0.8	1.4	-0.8	-0.8	0.2
Forced vital capacity (FVC), Best measure	1.1	3.9	10.7	1.2	1.9	-3.3	1.9	1.9	0.6
Body fat percentage	0.6	2.3	6.6	-1.5	-1.4	2.6	-1.4	-0.6	-1.0
Leg fat percentage (right)	1.0	3.7	11.6	-1.8	-1.4	3.4	-1.4	-0.1	-1.9
Arm fat-free mass (right)	1.1	5.9	9.5	2.2	2.1	-3.1	2.2	2.0	2.7
Exposure to tobacco smoke outside home	1.2	1.6	3.5	-1.9	-1.2	0.9	-1.3	-0.0	1.4
Comparative body size at age 10	0.5	1.3	3.8	-0.7	-1.1	1.9	-1.0	-0.8	-0.9
Number of full brothers	1.1	1.4	7.8	0.3	0.3	0.6	0.2	0.4	2.8
Worry too long after embarrassment	2.7	4.6	10.1	-2.3	-1.9	1.8	-2.0	-3.2	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	-1.2	-0.6	1.4	-0.6	-0.1	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.1	0.5	0.6	0.4	0.1	-0.2
Number of children fathered	1.9	2.2	3.5	-1.0	-1.8	1.9	-1.7	-1.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	0.7	-0.2	1.2	-0.2	-0.2	0.8
Age at first live birth	1.2	2.2	4.3	2.1	1.8	-0.4	1.9	1.1	-0.5
Pulse wave peak to peak time	0.4	0.5	1.9	-0.2	-0.3	0.1	-0.3	-0.8	1.4
Health satisfaction	1.0	1.3	2.3	-1.4	-0.8	0.6	-0.9	-1.4	-1.5
Shortness of breath walking on level ground	0.4	0.4	1.2	0.1	0.3	0.7	0.3	-0.9	1.1
Qualifications: College or University degree	0.9	2.7	4.0	2.0	1.6	-2.0	1.7	1.6	0.7
Eye problems/disorders: None of the above	1.2	1.4	7.1	-0.5	-0.5	0.2	-0.5	-0.7	-2.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	0.9	1.2	-1.1	1.2	1.1	-1.6
Emphysema/chronic bronchitis	0.1	0.2	0.7	-0.8	0.3	-0.1	0.2	0.2	0.3
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	0.8	1.4	-1.2	1.4	-0.2	-1.1
Neck or shoulder pain in last month	0.1	0.2	0.8	-0.5	-0.1	0.2	-0.1	0.3	-0.9
Medication: Blood pressure	0.1	0.3	0.4	-0.1	-0.5	0.6	-0.5	-0.7	0.5
Angina (self-reported)	0.5	0.6	3.0	-0.2	-0.1	0.5	-0.1	-0.6	-1.7
Migraine (self-reported)	0.3	0.4	1.0	-0.7	-0.1	0.9	-0.1	-0.3	-1.0
Medication: Ibuprofen	0.8	0.9	2.0	-1.1	-1.4	0.3	-1.4	-0.3	-0.2
Medication: Allopurinol	0.6	0.7	3.8	0.7	0.1	0.2	0.1	-0.2	1.9
Medication: Omeprazole	0.6	0.7	2.6	-0.1	-0.5	1.6	-0.5	-0.6	0.9
Medication: Seretide 50 evohaler	0.8	1.0	3.3	-0.3	-0.2	1.0	-0.1	-1.2	-1.8
Mean time to correctly identify matches	0.6	1.2	3.1	-0.6	-1.4	0.6	-1.3	0.1	1.8
Heart disease (mother)	1.7	2.1	7.3	1.2	0.4	0.6	0.5	-1.6	-2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	0.7	1.2	-0.1	1.2	0.5	-0.5
Whole body fat mass	0.1	0.4	1.5	-0.7	-0.6	1.2	-0.5	0.1	-0.1
Leg fat mass (right)	0.2	0.8	3.3	-0.7	-0.6	1.8	-0.5	0.1	-0.5
Arm predicted mass (right)	1.2	6.3	11.6	2.1	2.1	-3.4	2.2	2.3	2.8
Pulse rate, automated reading	0.3	1.1	3.1	-0.7	-0.3	0.8	-0.4	1.4	-1.8
Alcohol intake frequency.	1.1	2.5	7.0	-1.0	-1.2	2.6	-1.2	-0.5	-1.9
Comparative height size at age 10	6.1	33.7	45.6	5.7	5.8	-6.8	5.9	5.0	5.5
Number of full sisters	3.7	4.5	5.9	-2.0	-2.1	2.0	-2.1	-2.2	-2.4
Suffer from ‘nerves’	3.5	5.4	8.1	-2.1	-2.7	2.2	-2.7	-2.8	0.5
Overall health rating	1.9	4.1	6.5	-2.5	-1.8	1.8	-1.8	-1.5	-2.5
Chest pain or discomfort	1.3	1.9	5.0	-1.4	-1.1	0.9	-1.0	-1.1	-2.2
Had major operations	1.2	1.4	2.3	-0.6	-1.3	1.5	-1.3	-1.2	-1.0
Age at last live birth	3.0	4.3	8.1	2.8	2.7	-0.2	2.7	1.9	-0.1
Family relationship satisfaction	0.2	0.3	0.7	0.3	0.6	-0.2	0.6	0.8	-0.4
Leg pain on walking	0.5	0.6	1.0	-0.8	-1.0	1.0	-0.9	-0.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	0.6	0.4	0.9	0.4	-0.4	-0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.1	1.5	1.4	-1.1	1.3	1.4	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	-0.4	-0.2	0.5	-0.2	-0.9	0.8
Medication: Aspirin	0.9	1.2	2.0	-1.4	-1.4	0.4	-1.3	-1.2	-0.3
Supplements: Vitamin C	0.1	0.2	0.6	-0.1	-0.3	-0.2	-0.3	-0.1	0.8
Knee pain experienced in last month	2.3	3.6	5.3	-2.1	-1.9	1.8	-1.8	-1.4	-2.3
Hypertension (Self-reported)	3.5	9.9	14.7	-3.4	-3.8	3.0	-3.8	-2.9	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.6	1.1	0.4	0.0	0.4	0.8	1.9
Illnesses of father: Heart disease	4.5	6.2	14.5	-2.0	-2.1	1.3	-2.1	-3.8	-2.9
Illnesses of siblings: Diabetes	0.7	0.8	1.8	-0.9	-1.0	0.5	-1.0	-1.3	-0.3
Smoking status: Previous	0.5	0.7	1.5	1.2	0.6	-0.2	0.7	0.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.6	6.7	2.5	2.5	-2.5	2.6	1.6	2.4
Whole body fat-free mass	1.3	7.4	10.9	2.7	2.4	-3.2	2.5	2.0	3.3
Leg fat-free mass (right)	0.7	3.6	7.6	1.7	1.4	-2.4	1.6	0.8	2.8
Arm fat percentage (left)	1.4	5.4	13.8	-2.2	-2.2	3.7	-2.1	-1.7	-1.1
Average weekly red wine intake	0.1	0.1	0.5	0.0	-0.2	-0.3	-0.2	-0.7	-0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.5	-0.9	-0.7	1.1	-0.8	-1.9	-0.8
Mood swings	3.1	5.6	10.4	-3.2	-2.9	2.0	-2.9	-1.6	-0.5
Loneliness, isolation	2.1	2.9	5.2	-2.3	-1.3	1.8	-1.3	-1.9	-1.4
Long-standing illness, disability or infirmity	1.2	1.8	4.3	-1.2	-1.0	1.3	-1.0	-2.1	-1.2
Ever had bowel cancer screening	0.3	0.4	1.4	0.6	-0.1	1.2	-0.1	-0.1	0.8
Diabetes diagnosed by doctor	0.8	1.3	3.9	-0.0	0.3	0.8	0.3	-2.0	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.9	0.4	0.4	-1.3	0.4	-0.2	2.0
Friendships satisfaction	0.9	1.1	3.1	-1.8	-0.9	0.3	-1.0	-1.1	-0.7
Qualifications: nursing, teaching	0.3	0.5	2.1	-0.0	-0.4	0.5	-0.4	-0.2	-1.4
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.6	-0.8	0.4	-0.7	0.4	0.3
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.7	0.7	0.3	0.6	1.0	1.3
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	7.1	-1.1	-2.1	2.7	-2.1	-1.5	1.6
Medication for cholesterol	3.8	5.7	6.7	2.0	2.5	-2.2	2.5	2.6	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	-0.0	-0.1	0.9	-0.1	-0.7	0.1
Back pain experienced in last month	0.5	0.7	1.1	-0.4	-1.0	0.2	-0.9	-1.0	-1.0
Mineral and other dietary supplements	0.1	0.2	0.6	-0.3	-0.1	0.8	-0.1	0.2	0.7
Breast cancer (self-reported)	0.3	0.4	1.7	0.5	0.3	-1.3	0.4	0.3	0.0
Asthma (self-reported)	1.6	3.3	5.7	1.7	2.4	-0.7	2.4	2.0	1.0
Osteoporosis (self-reported)	0.4	0.5	2.4	-0.3	0.2	-0.1	0.1	-0.4	-1.6
Osteoarthritis (self-reported)	0.6	0.7	1.2	-1.1	-1.1	0.5	-1.1	0.5	0.6
Medication: Aspirin	0.6	0.7	1.1	-1.0	-1.0	0.2	-1.0	-1.0	-0.6
Medication: Gliclazide	2.6	3.0	12.2	-1.1	-0.9	0.1	-0.9	-1.7	-3.5
Illnesses of father: None of the above (group 1)	3.6	4.5	7.2	2.0	2.7	-2.3	2.6	1.7	0.7
Smoking status: Current	0.4	0.7	3.4	-0.6	0.2	-0.2	0.2	-0.4	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	-0.6	-1.0	1.5	-1.0	-0.0	-1.2
Whole body water mass	1.3	7.4	11.0	2.7	2.5	-3.2	2.6	1.9	3.3
Leg predicted mass (right)	0.7	3.5	7.3	1.7	1.4	-2.4	1.6	0.8	2.7
Arm fat mass (left)	0.2	0.8	2.8	-1.0	-0.8	1.7	-0.7	-0.3	-0.0
Number of self-reported non-cancer illnesses	2.9	5.0	7.7	-2.8	-2.1	2.4	-2.2	-2.1	-1.6
Average weekly champagne plus white wine intake	0.9	1.3	2.2	1.5	1.3	-1.2	1.3	0.7	-0.6
Miserableness	1.1	2.0	4.8	-1.8	-1.1	2.2	-1.1	-1.0	0.4
Guilty feelings	3.2	4.9	6.9	-2.6	-2.6	2.0	-2.6	-1.9	-1.1
Wears glasses or contact lenses	1.7	1.9	3.5	-1.9	-1.4	1.6	-1.5	-0.8	-0.9
Ever taken oral contraceptive pill	2.1	2.3	4.4	0.9	2.1	-1.7	2.0	0.2	-1.2
Hearing aid user	0.4	0.5	2.1	0.2	0.3	-0.6	0.1	-0.6	-1.4
Mother’s age at death	1.5	1.9	4.5	2.1	1.4	-1.1	1.5	0.7	-0.9
Financial situation satisfaction	2.2	2.8	5.1	-2.2	-1.8	1.5	-1.9	-1.5	-0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	-0.3	-0.2	1.1	-0.2	-0.7	-0.2
Commuting to job workplace: Public transport	1.5	1.8	3.7	-1.2	-1.2	1.5	-1.2	-0.7	-1.9
Eye problems/disorders: Glaucoma	0.5	0.6	2.7	0.1	0.4	-0.4	0.5	0.7	1.6
Medication: Blood pressure	4.3	8.2	10.6	-3.2	-3.2	2.9	-3.3	-2.6	-1.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	-0.4	-0.7	0.8	-0.7	-0.8	-1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	0.8	0.9	-0.9	0.9	0.3	-0.3
High cholesterol (Self-reported)	2.1	3.7	4.5	-2.1	-2.1	1.9	-2.1	-2.1	-1.0
Medication: Bendroflumethiazide	0.3	0.5	1.1	-0.9	-0.3	1.1	-0.3	-0.1	-0.9
Medication: Paracetamol	2.8	4.3	8.2	-2.4	-2.9	1.9	-2.9	0.3	0.7
Medication: Lisinopril	0.4	0.5	0.8	0.9	0.9	-0.0	0.8	0.5	-0.9
Medication: Atorvastatin	3.7	4.5	5.9	-2.3	-2.3	2.4	-2.3	-1.9	-1.5
Illnesses of father: High blood pressure	3.4	4.2	9.9	-1.3	-2.5	3.1	-2.5	-1.0	-0.2
Alcohol drinker status: Never	2.9	3.5	6.9	-1.1	-2.1	2.6	-2.1	-1.7	1.0
Ever smoked	0.1	0.2	0.5	-0.4	0.2	-0.7	0.2	-0.7	0.3
Basal metabolic rate	0.9	5.1	8.5	2.1	2.0	-2.6	2.1	1.6	2.9
Leg fat percentage (left)	0.9	3.4	9.9	-1.8	-1.5	3.2	-1.5	0.0	-1.8
Arm fat-free mass (left)	1.2	6.2	9.4	2.2	2.2	-3.1	2.3	2.2	2.8
Number of operations (self-reported)	0.4	0.6	1.4	0.4	-0.1	1.0	-0.1	-1.1	1.2
Average weekly beer plus cider intake	1.2	1.7	2.2	1.1	1.4	-1.1	1.4	1.5	1.3
Irritability	2.3	3.9	6.4	-2.5	-1.8	2.5	-1.8	-1.8	-0.8
Risk taking	3.1	4.5	6.9	2.3	2.6	-1.7	2.6	1.3	-1.9
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	0.3	0.2	0.7	0.2	0.1	-0.9
Fractured/broken bones in last 5 years	0.3	0.4	1.5	-0.4	-0.1	-0.1	-0.1	-1.2	0.7
Age started oral contraceptive pill	0.3	0.4	2.3	-0.2	0.0	1.5	-0.1	-0.3	-0.0
Diastolic blood pressure, automated reading	1.4	4.4	9.8	-3.1	-2.4	1.9	-2.5	-0.4	-0.9
Ever depressed for a whole week	2.2	2.7	6.9	-1.8	-1.8	0.3	-1.7	-0.4	-2.6
Unable to work because of sickness or disability	0.9	1.2	1.9	1.0	1.4	-0.7	1.4	-0.4	-1.3
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.2	-0.7	0.8	-0.6	0.2	0.5
Myopia	2.7	3.9	5.6	-2.0	-1.9	1.9	-1.9	-1.8	-2.4
Vascular/heart problems diagnosed by doctor	3.7	10.2	14.6	3.3	3.8	-3.1	3.8	3.2	1.4
Cholesterol lowering medication	4.3	6.3	8.9	-2.3	-2.5	2.8	-2.5	-3.0	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	0.5	-0.0	1.4	-0.0	0.0	1.2
Pain experienced in last month	0.9	1.5	3.0	1.2	1.2	-1.7	1.2	0.8	0.8
Supplements: Calcium	0.1	0.1	0.7	0.1	-0.0	-0.8	-0.1	0.1	0.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.1	1.0	1.0	0.7	0.9	1.0	0.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	-1.0	-0.9	0.6	-0.9	-1.7	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	4.3	-1.4	-2.1	1.0	-2.1	-1.7	-1.0
Heart disease (siblings)	3.4	4.2	7.6	-2.1	-1.9	2.0	-2.0	-1.1	-2.8
Alcohol drinker status: Previous	0.5	0.5	2.6	-0.3	0.1	0.5	0.1	0.4	-1.6
Pack years of smoking	0.1	0.1	0.4	0.1	0.1	-0.2	0.2	-0.6	-0.3
Impedance of whole body	0.1	0.6	1.6	0.4	1.0	-1.3	0.9	0.5	0.0
Leg fat mass (left)	0.1	0.5	2.1	-0.6	-0.5	1.5	-0.4	0.3	-0.4
Arm predicted mass (left)	1.3	6.5	9.6	2.3	2.3	-3.1	2.4	2.3	2.8