Hub : Genes

KIF17

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.247 0.0440 0.0e+00 0.194 0.206 0.171 0.208 0.205 4.5e-23 1.6e-24 2.7e-20 8.2e-25 2.1e-24
2 GTEx Brain Caudate basal ganglia 0.219 0.0990 7.9e-03 0.182 NA 0.058 NA 0.187 6.4e-06 NA 9.5e-03 NA 4.7e-06
3 GTEx Small Intestine Terminal Ileum 0.240 0.0940 2.4e-03 0.036 NA -0.006 NA 0.017 5.6e-02 NA 4.5e-01 NA 1.3e-01
4 GTEx Testis 0.189 0.0670 4.9e-05 0.233 NA 0.129 NA 0.234 1.0e-10 NA 2.5e-06 NA 9.7e-11
5 ROSMAP Brain Pre-frontal Cortex 0.151 0.0331 6.7e-14 0.114 0.123 0.164 0.130 0.146 2.0e-14 1.6e-15 1.7e-20 2.1e-16 2.5e-18
6 TCGA Esophageal Carcinoma 0.156 0.0790 9.4e-03 0.066 0.067 0.031 NA 0.049 3.8e-03 3.6e-03 3.7e-02 NA 1.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.1 0.2 0.8 -0.1 -0.2 -0.9 -0.1 -0.4 0.4
Bipolar Disorder or Schizophrenia 0.9 2.2 3.6 -1.7 -1.9 1.1 -1.9 -1.5 -0.2
Depressed Affect (Nagel 2018) 2.7 5.8 9.4 -3.1 -2.6 2.6 -2.6 -2.1 -0.4
Depression (Nagel 2018) 1.8 2.7 7.8 -2.8 -1.6 1.5 -1.7 -0.7 -0.5
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.4 -0.9 -1.6 0.5 -1.5 -0.9 -1.1
Neuroticism (Nagel 2018) 4.8 11.3 17.9 -4.2 -3.5 3.4 -3.6 -3.5 -1.3
Schizophrenia (2018) 1.8 3.8 5.4 -2.0 -2.3 2.2 -2.3 -1.6 -0.7
Schizophrenia vs Biploar Disorder 5.0 6.6 10.6 -3.3 -3.1 2.4 -3.2 -1.5 -0.5
Worry (Nagel 2018) 3.6 7.6 12.5 -3.5 -2.9 2.2 -3.0 -3.3 -0.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.3 -1.0 -1.1 0.7 -1.1 -0.5 0.4
Alzheimer’s Disease (in father) 0.0 0.0 0.0 -0.2 0.1 -0.0 0.0 0.1 -0.2
Alzheimer’s Disease (including proxy) 1.6 2.3 3.6 -1.8 -1.9 1.4 -1.9 -1.2 -0.1
Crohns Disease (2017) 0.1 0.2 0.6 0.7 0.2 0.1 0.3 0.3 0.8
Irritable Bowel Disease (IBD) 0.1 0.1 0.6 0.1 -0.2 0.8 -0.2 -0.0 0.2
Ulcerative Colitis (UC) 0.7 1.4 3.8 -1.0 -1.2 1.9 -1.2 -0.5 -0.5
Major Depression (MDD) 1.8 2.2 5.1 -2.3 -1.4 1.4 -1.4 -1.3 -0.4
Reaction Time 0.5 0.9 4.7 0.4 0.0 -0.5 0.1 0.5 2.2
Verbal and Numeric Reasoning (VNR) 1.3 3.2 4.9 -1.3 -2.2 1.4 -2.2 -1.9 -1.6
Breast Cancer 0.4 1.0 2.7 -1.1 -0.8 0.1 -0.8 -1.0 -1.6
Ovarian Cancer 1.2 1.5 2.8 1.5 1.7 -0.1 1.7 0.3 -1.2
Prostate Cancer 0.4 0.6 1.3 -0.7 -1.2 -0.1 -1.1 -0.5 -0.5
Age at First Birth 0.8 1.1 2.1 1.1 1.0 -1.0 1.1 0.6 1.4
Bipolar Disorder (2011) 0.3 0.3 0.5 -0.5 -0.6 0.5 -0.6 0.2 0.7
Body Mass Index (BMI) (2010) 0.2 0.3 0.9 -0.4 0.0 1.0 0.0 -0.9 0.0
Coronary Artery Disease (CAD) 1.8 2.1 6.2 -1.4 -1.0 1.5 -1.0 -2.5 -0.7
Crohns Disease (2012) 0.9 1.5 6.5 0.7 0.5 1.0 0.4 0.7 2.5
Mean Putamen Volume 0.5 0.5 1.0 -0.8 -1.0 0.1 -1.0 0.4 0.8
Fasting Glucose 0.7 0.8 2.3 0.2 0.5 -1.0 0.4 -1.1 -1.5
HbA1C 0.4 0.4 1.2 -0.4 -0.4 0.4 -0.4 -0.9 -1.1
HDL Cholesterol 0.9 1.5 4.6 1.0 0.6 -0.8 0.6 2.1 1.3
LDL Cholesterol 1.6 2.5 4.2 -1.3 -1.4 1.9 -1.4 -2.0 -1.2
Lupus 1.4 2.1 3.0 1.7 1.6 -0.8 1.6 1.6 1.2
Neuroticism (2016) 2.8 4.0 8.2 -2.9 -2.4 1.0 -2.4 -1.8 -0.2
Primary Biliary Cirrhosis 0.7 1.0 2.3 -1.5 -0.9 0.8 -0.9 0.5 0.9
Rheumatoid Arthritis 0.2 0.3 0.4 -0.6 -0.4 0.4 -0.5 0.7 -0.5
Schizophrenia (2014) 1.2 2.6 3.8 -1.7 -1.9 1.9 -1.9 -1.2 -0.5
Triglycerides 0.3 0.5 1.9 -0.6 0.1 0.7 -0.0 -0.6 -1.4
Type 2 Diabetes (T2D) (2012) 0.8 1.0 2.8 -0.9 -0.8 0.9 -0.9 -1.7 -0.3
Ulcerative Colitis 0.2 0.3 1.1 0.0 0.1 0.3 0.0 0.8 1.0
Blood Eosinophil Count 1.6 12.2 26.9 -4.0 -3.1 5.2 -3.2 -2.9 -1.3
Blood Platelet Count 0.7 8.2 17.2 -3.9 -2.2 2.5 -2.3 0.4 -4.2
Blood Red Count 1.5 14.9 34.5 -4.2 -3.7 5.9 -4.0 -1.9 -2.0
Blood White Count 0.3 2.5 9.5 -1.5 0.0 1.8 -0.2 0.2 -3.1
Heel T-Score 0.4 3.3 5.6 2.4 1.6 -0.2 1.7 2.0 2.1
BMI 0.2 1.1 2.9 -0.9 -1.1 1.7 -1.0 -0.1 -0.5
Height 4.7 90.9 148.8 9.8 9.7 -12.2 9.9 7.0 7.5
Waist Hip Ratio (WHR) 1.2 5.2 8.8 -3.0 -2.1 2.5 -2.3 -2.5 -0.9
Systolic Blood Pressure 1.3 6.4 13.4 -3.7 -3.0 1.8 -3.2 -1.7 -0.2
Smoking Status 0.8 2.0 4.0 1.3 1.5 -2.0 1.6 0.6 -0.8
Allergy or Eczema 0.1 0.4 1.0 0.4 0.5 0.5 0.6 1.0 -0.4
Cardiovascular Disease 3.3 10.9 16.3 -3.9 -4.0 2.6 -4.0 -3.1 -1.0
Hypothyroidism (self reported) 0.4 1.0 2.4 -1.1 -0.8 0.9 -0.7 -0.6 1.6
Respiratory disease 1.2 2.7 5.0 1.7 2.2 -0.4 2.2 1.8 0.4
Type 2 Diabetes (T2D) (2018) 0.6 1.2 4.7 0.3 0.8 -0.5 0.7 -1.0 -2.2
Lung FEV1/FVC ratio 0.9 4.4 8.4 -2.0 -2.2 2.9 -2.2 -2.1 0.0
Lung FVC 1.3 6.8 12.3 -2.6 -2.5 2.9 -2.6 -1.0 -3.5
Neuroticism 4.5 11.0 17.3 -4.2 -3.5 2.9 -3.6 -3.8 -1.0
Chronotype (morning person) 3.6 8.3 17.7 3.3 2.1 -3.3 2.3 4.2 0.6
Hair Pigment 0.1 1.5 2.6 1.5 1.6 -0.5 1.6 0.5 0.9
Tanning 0.5 6.5 10.4 3.2 3.2 -2.4 3.1 1.6 -0.2
Hand grip strength (left) 1.1 2.9 5.9 2.0 1.6 -2.4 1.6 -0.3 1.5
Number of treatments/medications taken 1.2 2.1 3.6 -1.6 -1.9 1.1 -1.9 -0.8 -1.0
Average weekly spirits intake 0.5 0.6 1.0 -1.0 -0.9 0.7 -1.0 0.5 -0.3
Sensitivity / hurt feelings 2.3 3.9 5.7 -2.4 -2.0 1.7 -2.0 -2.0 -1.7
Frequency of depressed mood in last 2 weeks 3.3 4.6 9.2 -3.0 -2.4 1.6 -2.5 -1.9 -0.5
Hearing difficulty/problems: Yes 0.3 0.4 0.7 -0.3 -0.8 0.8 -0.8 -0.5 0.3
Relative age of first facial hair 0.0 0.0 0.1 -0.0 0.0 -0.1 0.1 0.1 0.2
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.2 -1.1 -0.9 1.0 -1.0 -0.8 -0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.6 1.9 -0.5 -0.5 -0.2 -0.6 0.8 -1.4
Ever had hysterectomy (womb removed) 0.5 0.5 1.2 -0.9 -0.1 0.5 -0.2 -1.1 -0.9
Systolic blood pressure, automated reading 1.0 2.9 4.6 -1.9 -1.8 2.1 -1.9 -0.9 -1.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.5 -1.2 -0.3 1.0 -0.4 -0.1 0.0
Angina 0.5 0.7 2.5 -0.3 -0.2 0.6 -0.2 -1.0 -1.6
Medication for hormone replacement therapy 0.5 0.5 1.5 0.4 -0.7 0.5 -0.7 -1.2 -0.7
Vitamin and mineral supplements 0.1 0.1 0.4 0.1 0.6 0.1 0.6 -0.2 -0.3
Supplements: Zinc 0.2 0.2 0.6 -0.7 0.2 -0.8 0.1 0.4 -0.3
Medication: Co-codamol 1.4 1.6 2.9 -1.4 -1.7 0.8 -1.6 0.7 -1.1
Medication: Metformin 1.9 2.7 4.3 1.8 2.0 -0.8 1.9 -0.7 -2.1
Diabetes (father) 0.9 1.1 3.3 -1.4 -0.7 0.3 -0.7 -0.5 -1.8
Diabetes (mother) 0.2 0.3 1.3 0.2 -0.0 -0.4 -0.0 1.1 -0.2
Severe depression (siblings) 1.3 1.5 3.3 -1.7 -0.9 1.8 -1.0 -1.0 -0.3
Pack years adult smoking proportion 0.2 0.2 0.3 0.6 0.5 -0.5 0.6 -0.5 -0.2
Impedance of leg (right) 0.3 1.4 2.1 0.6 1.4 -1.1 1.3 1.4 -0.8
Leg fat-free mass (left) 0.5 2.8 6.5 1.6 1.3 -2.0 1.4 0.4 2.5
Trunk fat percentage 0.4 1.7 4.7 -1.2 -1.2 2.2 -1.2 -0.7 -0.7
Hand grip strength (right) 1.5 4.0 6.2 2.4 2.0 -2.5 2.0 0.6 1.9
Townsend deprivation index at recruitment 1.0 1.4 5.0 -0.5 -0.9 0.3 -0.8 -2.2 -1.2
Current tobacco smoking 0.3 0.5 1.7 -0.5 0.2 -0.5 0.2 -0.8 -1.3
Average weekly fortified wine intake 0.3 0.4 1.5 -0.1 -0.0 0.7 -0.1 -0.4 -1.2
Maternal smoking around birth 0.2 0.4 1.8 -0.1 0.1 -1.3 0.1 -0.5 0.3
Fed-up feelings 4.6 8.3 13.6 -3.7 -3.5 2.4 -3.5 -2.6 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 5.5 -2.4 -1.3 2.2 -1.4 -1.1 -0.7
Relative age voice broke 1.0 1.6 4.2 0.1 -0.5 1.6 -0.5 -1.5 2.0
Taking other prescription medications 0.5 0.8 1.3 -1.1 -1.0 1.1 -1.0 -0.3 -0.5
Age when periods started (menarche) 0.9 2.1 4.5 2.1 1.8 -1.0 1.9 0.7 -0.2
Bilateral oophorectomy (both ovaries removed) 3.5 4.1 6.2 -2.3 -2.4 1.5 -2.5 -2.2 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 6.1 -0.1 -1.0 0.4 -0.9 -1.1 2.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.1 -1.0 -0.8 -0.4 -0.8 -0.3 1.1
Qualifications: CSEs or equivalent 0.7 0.9 2.0 -1.4 -1.0 0.5 -1.1 -1.1 0.1
Serious illness, injury or assault to yourself 0.1 0.2 0.7 0.3 -0.2 0.1 -0.2 -0.9 -0.3
High blood pressure 2.6 7.4 11.0 -2.9 -3.3 2.7 -3.3 -2.4 -1.0
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 -0.2 0.0 0.8 0.1 0.4 -0.6
Multivitamins +/- minerals 0.2 0.3 0.4 -0.7 -0.6 0.5 -0.6 -0.0 -0.3
Stomach or abdominal pain in last month 2.1 2.6 5.2 -1.5 -1.7 2.3 -1.7 -1.4 0.6
Supplements: Glucosamine 0.4 0.5 0.9 1.0 0.5 -0.9 0.5 -0.3 -0.8
Diverticular disease/diverticulitis (self-reported) 1.8 2.2 6.8 -1.5 -1.3 2.6 -1.4 -0.2 0.5
Medication: Atenolol 0.3 0.3 1.1 -0.4 -0.5 0.6 -0.5 -1.0 -0.1
Medication: Levothyroxine sodium 0.3 0.5 1.8 -0.3 -0.4 1.4 -0.3 -0.4 0.7
Sitting height 2.1 15.2 28.4 2.8 3.6 -5.3 3.6 2.6 4.7
Chronic bronchitis/emphysema (father) 0.4 0.4 1.1 -0.4 -1.0 0.6 -1.0 -0.2 0.2
High blood pressure (mother) 1.3 1.8 3.1 -1.0 -1.3 1.8 -1.2 -1.6 0.9
Body mass index (BMI) 0.9 3.7 9.5 -1.9 -1.9 3.1 -1.9 -0.8 -1.1
Impedance of leg (left) 0.4 1.8 3.5 0.7 1.5 -1.6 1.4 1.9 -0.6
Leg predicted mass (left) 0.6 3.1 6.8 1.7 1.4 -2.1 1.6 0.5 2.6
Trunk fat mass 0.1 0.3 1.1 -0.4 -0.4 1.1 -0.3 0.1 0.2
Waist circumference 0.7 2.4 5.2 -1.8 -1.7 2.3 -1.6 -0.8 -0.5
Number of incorrect matches in round 3.7 6.2 11.1 -3.3 -2.8 2.6 -2.8 -1.4 -1.4
Past tobacco smoking 0.1 0.2 0.4 -0.6 -0.6 0.5 -0.6 -0.1 -0.3
Alcohol usually taken with meals 0.1 0.2 0.7 0.2 0.0 -0.8 0.1 -0.6 -0.5
Nervous feelings 2.8 5.2 7.5 -2.7 -2.6 1.6 -2.7 -2.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 4.2 -2.0 -1.1 0.5 -1.2 -0.7 0.4
Hearing difficulty/problems with background noise 0.5 0.9 4.7 0.6 -0.0 0.2 0.0 -0.3 2.2
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 0.7 0.6 -0.2 0.5 0.5 -0.2
Had menopause 1.4 1.7 5.4 1.1 1.2 -2.3 1.2 0.1 -0.9
Had other major operations 2.3 2.7 4.4 1.7 1.6 -2.0 1.6 0.3 2.1
Forced vital capacity (FVC) 0.8 3.0 9.7 0.7 1.6 -3.1 1.6 1.5 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 6.0 0.7 -0.1 0.1 -0.0 -0.3 2.5
Ever unenthusiastic/disinterested for a whole week 5.1 6.2 10.6 -3.2 -2.8 1.5 -2.8 -1.6 -2.5
Qualifications: None of the above 0.4 0.8 1.3 -0.9 -1.1 1.1 -1.1 -0.3 0.6
Financial difficulties in last 2 years 0.6 0.8 2.8 -0.1 0.8 -1.7 0.8 0.7 0.2
Mouth/teeth dental problems 0.2 0.3 0.6 -0.1 -0.5 0.3 -0.5 -0.7 0.8
Heart attack 1.3 1.6 4.6 -1.2 -1.2 0.8 -1.2 -2.1 -0.6
Allergy 0.1 0.3 1.0 0.2 -0.5 -0.7 -0.5 -1.0 -0.2
Pain all over the body in last month 0.4 0.5 1.3 -0.2 -0.6 0.5 -0.7 -0.6 1.1
Diabetes (self-reported) 0.7 1.2 4.5 0.5 0.7 0.4 0.6 -1.1 -2.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.8 1.3 0.9 -0.4 0.9 0.8 0.3
Medication: Ramipril 1.0 1.3 3.2 -1.8 -1.1 0.8 -1.1 -0.5 -1.2
Medication: Simvastatin 2.1 3.2 4.1 -1.6 -2.0 1.8 -2.0 -1.9 -1.0
Fluid intelligence score 0.3 0.6 2.5 -0.2 -0.5 0.4 -0.4 0.5 -1.6
Illnesses of siblings 2.4 3.3 4.6 1.8 2.1 -2.0 2.1 1.6 0.9
Neuroticism score 6.5 13.7 20.6 -4.5 -3.8 3.3 -3.9 -4.3 -1.5
Weight 0.2 1.0 2.7 0.7 0.7 -0.7 0.9 1.0 1.6
Impedance of arm (right) 0.1 0.6 0.9 0.8 0.9 -0.4 0.9 -0.4 1.0
Arm fat percentage (right) 0.9 3.7 11.5 -1.6 -1.7 3.4 -1.6 -1.3 -0.9
Trunk fat-free mass 1.9 11.0 15.0 3.2 3.1 -3.9 3.2 2.7 3.7
Hip circumference 0.0 0.2 0.8 0.2 0.3 -0.1 0.4 0.9 0.4
Time employed in main current job 2.0 2.3 3.8 -1.6 -2.0 1.3 -1.9 -1.1 -0.8
Alcohol intake versus 10 years previously 0.9 1.3 5.7 -0.4 -0.5 1.2 -0.5 -0.4 -2.4
Father’s age at death 1.2 1.6 2.9 1.7 1.5 -0.2 1.6 1.3 0.2
Worrier / anxious feelings 4.0 7.5 13.8 -3.7 -2.9 2.1 -2.9 -2.9 -1.3
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 6.5 -2.5 -2.2 2.2 -2.2 -1.4 -0.8
Falls in the last year 0.7 1.0 2.8 0.2 -0.3 -0.9 -0.3 1.5 1.7
Hair/balding pattern: Pattern 3 1.0 1.4 3.0 -1.7 -1.2 0.8 -1.2 -1.1 -1.0
Number of live births 0.1 0.2 0.6 -0.4 -0.1 0.4 -0.1 0.5 0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.2 -0.4 0.4 -1.5 0.3 -0.0 0.3
Pulse rate 0.6 1.0 1.2 0.7 1.1 -0.9 1.0 1.1 -1.1
Happiness 1.0 1.2 3.1 -1.4 -0.7 1.8 -0.8 0.1 -1.1
Noisy workplace 0.1 0.1 0.5 0.5 0.0 -0.1 0.0 -0.3 -0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.1 1.1 0.8 0.9 0.8 0.6 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.7 0.8 1.3 -0.9 1.2 1.3 -0.7
Mouth/teeth dental problems: Dentures 1.2 2.0 2.8 1.3 1.7 -1.5 1.7 1.4 0.5
Asthma 1.8 3.6 6.2 1.7 2.5 -0.7 2.5 2.0 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 -0.9 -1.1 0.7 -1.1 -0.1 0.4
Medication: Cholesterol lowering 1.0 1.6 3.0 -1.0 -1.3 0.3 -1.2 -1.5 -1.7
Depression (self-reported) 0.6 0.7 3.2 -0.6 -0.4 -0.1 -0.4 0.0 -1.8
Medication: Lansoprazole 0.1 0.1 0.3 0.6 -0.0 0.5 -0.0 0.0 0.5
Prospective memory result 0.2 0.3 0.8 -0.2 -0.3 -0.8 -0.2 -0.1 0.9
Lung cancer (father) 1.3 1.5 2.2 1.4 1.1 -1.5 1.2 1.3 -0.7
Illnesses of mother 1.5 1.8 3.5 0.7 1.4 -1.8 1.4 1.9 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 2.1 -0.1 0.6 -1.4 0.5 0.4 0.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 0.5 0.6 -0.7 0.6 1.0 -0.9
Impedance of arm (left) 0.0 0.1 0.4 0.2 0.4 -0.2 0.3 -0.6 0.4
Arm fat mass (right) 0.2 0.8 3.1 -0.8 -0.7 1.8 -0.6 -0.4 -0.1
Trunk predicted mass 1.9 10.8 14.6 3.2 3.0 -3.8 3.1 2.7 3.7
Standing height 3.9 38.5 71.7 5.7 5.9 -8.5 6.0 4.4 6.0
Length of working week for main job 0.5 0.5 1.3 0.8 0.2 -1.2 0.3 0.9 0.3
Exposure to tobacco smoke at home 1.0 1.1 1.6 -0.7 -1.2 1.3 -1.2 -0.6 1.1
Breastfed as a baby 1.0 1.2 1.5 -1.2 -1.2 0.4 -1.2 -1.2 -1.2
Tense / ‘highly strung’ 1.5 2.5 5.9 -1.9 -1.4 1.3 -1.4 -2.4 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.4 -1.9 -1.4 0.4 -1.4 -1.4 -1.2
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 0.3 -0.1 0.3 -0.1 0.0 -0.5
Birth weight of first child 0.2 0.3 1.0 -0.4 -0.6 -0.2 -0.5 0.2 -1.0
Peak expiratory flow (PEF) 0.3 0.6 1.6 -1.2 -0.4 0.2 -0.5 -1.3 -0.4
Pulse wave reflection index 0.3 0.4 0.9 0.2 0.8 -0.0 0.8 0.9 0.3
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.7 -1.3 -0.9 -1.0 -0.9 -0.0 -0.7
Loud music exposure frequency 0.8 0.9 2.0 -0.1 0.7 -1.4 0.6 0.8 -1.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 0.9 0.9 0.9 -0.6 0.9 0.9 -0.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.3 -0.8 0.0 0.9 -0.1 0.5 -1.5
Blood clot in the leg (DVT) 2.5 3.2 5.1 -1.5 -2.3 1.2 -2.2 -2.0 -1.2
Medication: Paracetamol 2.1 3.5 6.0 -1.9 -2.4 1.8 -2.4 0.6 1.3
Headache pain in last month 1.5 2.5 5.2 -1.6 -1.6 2.3 -1.6 -0.9 -1.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.4 0.6 1.1 0.0 1.1 1.2 0.5
Glaucoma (self-reported) 0.4 0.5 1.8 0.4 0.5 0.1 0.5 1.3 0.7
Gout (self-reported) 0.6 0.8 4.5 0.4 -0.1 0.3 -0.1 0.1 2.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.5 4.0 -1.0 -1.1 2.0 -1.0 -0.9 1.0
Medication: Amlodipine 1.3 1.8 2.6 -1.1 -1.6 1.5 -1.6 -1.4 0.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.5 0.2 0.6 -0.2 0.6 1.2 0.7
Birth weight 0.1 0.2 0.8 0.2 -0.1 0.9 -0.1 0.4 0.2
Chronic bronchitis/emphysema (mother) 1.3 1.5 4.1 1.1 1.3 0.4 1.2 2.0 0.5
High blood pressure (siblings) 0.5 0.7 1.9 -0.8 -0.8 1.4 -0.8 -0.8 0.2
Forced vital capacity (FVC), Best measure 1.1 3.9 10.7 1.2 1.9 -3.3 1.9 1.9 0.6
Body fat percentage 0.6 2.3 6.6 -1.5 -1.4 2.6 -1.4 -0.6 -1.0
Leg fat percentage (right) 1.0 3.7 11.6 -1.8 -1.4 3.4 -1.4 -0.1 -1.9
Arm fat-free mass (right) 1.1 5.9 9.5 2.2 2.1 -3.1 2.2 2.0 2.7
Exposure to tobacco smoke outside home 1.2 1.6 3.5 -1.9 -1.2 0.9 -1.3 -0.0 1.4
Comparative body size at age 10 0.5 1.3 3.8 -0.7 -1.1 1.9 -1.0 -0.8 -0.9
Number of full brothers 1.1 1.4 7.8 0.3 0.3 0.6 0.2 0.4 2.8
Worry too long after embarrassment 2.7 4.6 10.1 -2.3 -1.9 1.8 -2.0 -3.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.1 -1.2 -0.6 1.4 -0.6 -0.1 -0.5
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 0.1 0.5 0.6 0.4 0.1 -0.2
Number of children fathered 1.9 2.2 3.5 -1.0 -1.8 1.9 -1.7 -1.5 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.5 0.7 -0.2 1.2 -0.2 -0.2 0.8
Age at first live birth 1.2 2.2 4.3 2.1 1.8 -0.4 1.9 1.1 -0.5
Pulse wave peak to peak time 0.4 0.5 1.9 -0.2 -0.3 0.1 -0.3 -0.8 1.4
Health satisfaction 1.0 1.3 2.3 -1.4 -0.8 0.6 -0.9 -1.4 -1.5
Shortness of breath walking on level ground 0.4 0.4 1.2 0.1 0.3 0.7 0.3 -0.9 1.1
Qualifications: College or University degree 0.9 2.7 4.0 2.0 1.6 -2.0 1.7 1.6 0.7
Eye problems/disorders: None of the above 1.2 1.4 7.1 -0.5 -0.5 0.2 -0.5 -0.7 -2.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.5 0.9 1.2 -1.1 1.2 1.1 -1.6
Emphysema/chronic bronchitis 0.1 0.2 0.7 -0.8 0.3 -0.1 0.2 0.2 0.3
Medication for pain relief, constipation, heartburn 0.7 1.2 2.0 0.8 1.4 -1.2 1.4 -0.2 -1.1
Neck or shoulder pain in last month 0.1 0.2 0.8 -0.5 -0.1 0.2 -0.1 0.3 -0.9
Medication: Blood pressure 0.1 0.3 0.4 -0.1 -0.5 0.6 -0.5 -0.7 0.5
Angina (self-reported) 0.5 0.6 3.0 -0.2 -0.1 0.5 -0.1 -0.6 -1.7
Migraine (self-reported) 0.3 0.4 1.0 -0.7 -0.1 0.9 -0.1 -0.3 -1.0
Medication: Ibuprofen 0.8 0.9 2.0 -1.1 -1.4 0.3 -1.4 -0.3 -0.2
Medication: Allopurinol 0.6 0.7 3.8 0.7 0.1 0.2 0.1 -0.2 1.9
Medication: Omeprazole 0.6 0.7 2.6 -0.1 -0.5 1.6 -0.5 -0.6 0.9
Medication: Seretide 50 evohaler 0.8 1.0 3.3 -0.3 -0.2 1.0 -0.1 -1.2 -1.8
Mean time to correctly identify matches 0.6 1.2 3.1 -0.6 -1.4 0.6 -1.3 0.1 1.8
Heart disease (mother) 1.7 2.1 7.3 1.2 0.4 0.6 0.5 -1.6 -2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.4 0.7 1.2 -0.1 1.2 0.5 -0.5
Whole body fat mass 0.1 0.4 1.5 -0.7 -0.6 1.2 -0.5 0.1 -0.1
Leg fat mass (right) 0.2 0.8 3.3 -0.7 -0.6 1.8 -0.5 0.1 -0.5
Arm predicted mass (right) 1.2 6.3 11.6 2.1 2.1 -3.4 2.2 2.3 2.8
Pulse rate, automated reading 0.3 1.1 3.1 -0.7 -0.3 0.8 -0.4 1.4 -1.8
Alcohol intake frequency. 1.1 2.5 7.0 -1.0 -1.2 2.6 -1.2 -0.5 -1.9
Comparative height size at age 10 6.1 33.7 45.6 5.7 5.8 -6.8 5.9 5.0 5.5
Number of full sisters 3.7 4.5 5.9 -2.0 -2.1 2.0 -2.1 -2.2 -2.4
Suffer from ‘nerves’ 3.5 5.4 8.1 -2.1 -2.7 2.2 -2.7 -2.8 0.5
Overall health rating 1.9 4.1 6.5 -2.5 -1.8 1.8 -1.8 -1.5 -2.5
Chest pain or discomfort 1.3 1.9 5.0 -1.4 -1.1 0.9 -1.0 -1.1 -2.2
Had major operations 1.2 1.4 2.3 -0.6 -1.3 1.5 -1.3 -1.2 -1.0
Age at last live birth 3.0 4.3 8.1 2.8 2.7 -0.2 2.7 1.9 -0.1
Family relationship satisfaction 0.2 0.3 0.7 0.3 0.6 -0.2 0.6 0.8 -0.4
Leg pain on walking 0.5 0.6 1.0 -0.8 -1.0 1.0 -0.9 -0.3 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.8 0.6 0.4 0.9 0.4 -0.4 -0.4
Commuting to job workplace: Car/motor vehicle 1.3 1.5 2.1 1.5 1.4 -1.1 1.3 1.4 0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.9 -0.4 -0.2 0.5 -0.2 -0.9 0.8
Medication: Aspirin 0.9 1.2 2.0 -1.4 -1.4 0.4 -1.3 -1.2 -0.3
Supplements: Vitamin C 0.1 0.2 0.6 -0.1 -0.3 -0.2 -0.3 -0.1 0.8
Knee pain experienced in last month 2.3 3.6 5.3 -2.1 -1.9 1.8 -1.8 -1.4 -2.3
Hypertension (Self-reported) 3.5 9.9 14.7 -3.4 -3.8 3.0 -3.8 -2.9 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 3.6 1.1 0.4 0.0 0.4 0.8 1.9
Illnesses of father: Heart disease 4.5 6.2 14.5 -2.0 -2.1 1.3 -2.1 -3.8 -2.9
Illnesses of siblings: Diabetes 0.7 0.8 1.8 -0.9 -1.0 0.5 -1.0 -1.3 -0.3
Smoking status: Previous 0.5 0.7 1.5 1.2 0.6 -0.2 0.7 0.5 1.2
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.6 6.7 2.5 2.5 -2.5 2.6 1.6 2.4
Whole body fat-free mass 1.3 7.4 10.9 2.7 2.4 -3.2 2.5 2.0 3.3
Leg fat-free mass (right) 0.7 3.6 7.6 1.7 1.4 -2.4 1.6 0.8 2.8
Arm fat percentage (left) 1.4 5.4 13.8 -2.2 -2.2 3.7 -2.1 -1.7 -1.1
Average weekly red wine intake 0.1 0.1 0.5 0.0 -0.2 -0.3 -0.2 -0.7 -0.4
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.5 -0.9 -0.7 1.1 -0.8 -1.9 -0.8
Mood swings 3.1 5.6 10.4 -3.2 -2.9 2.0 -2.9 -1.6 -0.5
Loneliness, isolation 2.1 2.9 5.2 -2.3 -1.3 1.8 -1.3 -1.9 -1.4
Long-standing illness, disability or infirmity 1.2 1.8 4.3 -1.2 -1.0 1.3 -1.0 -2.1 -1.2
Ever had bowel cancer screening 0.3 0.4 1.4 0.6 -0.1 1.2 -0.1 -0.1 0.8
Diabetes diagnosed by doctor 0.8 1.3 3.9 -0.0 0.3 0.8 0.3 -2.0 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 3.9 0.4 0.4 -1.3 0.4 -0.2 2.0
Friendships satisfaction 0.9 1.1 3.1 -1.8 -0.9 0.3 -1.0 -1.1 -0.7
Qualifications: nursing, teaching 0.3 0.5 2.1 -0.0 -0.4 0.5 -0.4 -0.2 -1.4
Commuting to job workplace: Walk 0.3 0.3 0.6 -0.6 -0.8 0.4 -0.7 0.4 0.3
Eye problems/disorders: Cataract 0.6 0.7 1.6 0.7 0.7 0.3 0.6 1.0 1.3
Mouth/teeth dental problems: Mouth ulcers 2.3 3.6 7.1 -1.1 -2.1 2.7 -2.1 -1.5 1.6
Medication for cholesterol 3.8 5.7 6.7 2.0 2.5 -2.2 2.5 2.6 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.8 -0.0 -0.1 0.9 -0.1 -0.7 0.1
Back pain experienced in last month 0.5 0.7 1.1 -0.4 -1.0 0.2 -0.9 -1.0 -1.0
Mineral and other dietary supplements 0.1 0.2 0.6 -0.3 -0.1 0.8 -0.1 0.2 0.7
Breast cancer (self-reported) 0.3 0.4 1.7 0.5 0.3 -1.3 0.4 0.3 0.0
Asthma (self-reported) 1.6 3.3 5.7 1.7 2.4 -0.7 2.4 2.0 1.0
Osteoporosis (self-reported) 0.4 0.5 2.4 -0.3 0.2 -0.1 0.1 -0.4 -1.6
Osteoarthritis (self-reported) 0.6 0.7 1.2 -1.1 -1.1 0.5 -1.1 0.5 0.6
Medication: Aspirin 0.6 0.7 1.1 -1.0 -1.0 0.2 -1.0 -1.0 -0.6
Medication: Gliclazide 2.6 3.0 12.2 -1.1 -0.9 0.1 -0.9 -1.7 -3.5
Illnesses of father: None of the above (group 1) 3.6 4.5 7.2 2.0 2.7 -2.3 2.6 1.7 0.7
Smoking status: Current 0.4 0.7 3.4 -0.6 0.2 -0.2 0.2 -0.4 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 -0.6 -1.0 1.5 -1.0 -0.0 -1.2
Whole body water mass 1.3 7.4 11.0 2.7 2.5 -3.2 2.6 1.9 3.3
Leg predicted mass (right) 0.7 3.5 7.3 1.7 1.4 -2.4 1.6 0.8 2.7
Arm fat mass (left) 0.2 0.8 2.8 -1.0 -0.8 1.7 -0.7 -0.3 -0.0
Number of self-reported non-cancer illnesses 2.9 5.0 7.7 -2.8 -2.1 2.4 -2.2 -2.1 -1.6
Average weekly champagne plus white wine intake 0.9 1.3 2.2 1.5 1.3 -1.2 1.3 0.7 -0.6
Miserableness 1.1 2.0 4.8 -1.8 -1.1 2.2 -1.1 -1.0 0.4
Guilty feelings 3.2 4.9 6.9 -2.6 -2.6 2.0 -2.6 -1.9 -1.1
Wears glasses or contact lenses 1.7 1.9 3.5 -1.9 -1.4 1.6 -1.5 -0.8 -0.9
Ever taken oral contraceptive pill 2.1 2.3 4.4 0.9 2.1 -1.7 2.0 0.2 -1.2
Hearing aid user 0.4 0.5 2.1 0.2 0.3 -0.6 0.1 -0.6 -1.4
Mother’s age at death 1.5 1.9 4.5 2.1 1.4 -1.1 1.5 0.7 -0.9
Financial situation satisfaction 2.2 2.8 5.1 -2.2 -1.8 1.5 -1.9 -1.5 -0.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.2 -0.3 -0.2 1.1 -0.2 -0.7 -0.2
Commuting to job workplace: Public transport 1.5 1.8 3.7 -1.2 -1.2 1.5 -1.2 -0.7 -1.9
Eye problems/disorders: Glaucoma 0.5 0.6 2.7 0.1 0.4 -0.4 0.5 0.7 1.6
Medication: Blood pressure 4.3 8.2 10.6 -3.2 -3.2 2.9 -3.3 -2.6 -1.8
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.4 -0.4 -0.7 0.8 -0.7 -0.8 -1.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.8 0.9 -0.9 0.9 0.3 -0.3
High cholesterol (Self-reported) 2.1 3.7 4.5 -2.1 -2.1 1.9 -2.1 -2.1 -1.0
Medication: Bendroflumethiazide 0.3 0.5 1.1 -0.9 -0.3 1.1 -0.3 -0.1 -0.9
Medication: Paracetamol 2.8 4.3 8.2 -2.4 -2.9 1.9 -2.9 0.3 0.7
Medication: Lisinopril 0.4 0.5 0.8 0.9 0.9 -0.0 0.8 0.5 -0.9
Medication: Atorvastatin 3.7 4.5 5.9 -2.3 -2.3 2.4 -2.3 -1.9 -1.5
Illnesses of father: High blood pressure 3.4 4.2 9.9 -1.3 -2.5 3.1 -2.5 -1.0 -0.2
Alcohol drinker status: Never 2.9 3.5 6.9 -1.1 -2.1 2.6 -2.1 -1.7 1.0
Ever smoked 0.1 0.2 0.5 -0.4 0.2 -0.7 0.2 -0.7 0.3
Basal metabolic rate 0.9 5.1 8.5 2.1 2.0 -2.6 2.1 1.6 2.9
Leg fat percentage (left) 0.9 3.4 9.9 -1.8 -1.5 3.2 -1.5 0.0 -1.8
Arm fat-free mass (left) 1.2 6.2 9.4 2.2 2.2 -3.1 2.3 2.2 2.8
Number of operations (self-reported) 0.4 0.6 1.4 0.4 -0.1 1.0 -0.1 -1.1 1.2
Average weekly beer plus cider intake 1.2 1.7 2.2 1.1 1.4 -1.1 1.4 1.5 1.3
Irritability 2.3 3.9 6.4 -2.5 -1.8 2.5 -1.8 -1.8 -0.8
Risk taking 3.1 4.5 6.9 2.3 2.6 -1.7 2.6 1.3 -1.9
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.9 0.3 0.2 0.7 0.2 0.1 -0.9
Fractured/broken bones in last 5 years 0.3 0.4 1.5 -0.4 -0.1 -0.1 -0.1 -1.2 0.7
Age started oral contraceptive pill 0.3 0.4 2.3 -0.2 0.0 1.5 -0.1 -0.3 -0.0
Diastolic blood pressure, automated reading 1.4 4.4 9.8 -3.1 -2.4 1.9 -2.5 -0.4 -0.9
Ever depressed for a whole week 2.2 2.7 6.9 -1.8 -1.8 0.3 -1.7 -0.4 -2.6
Unable to work because of sickness or disability 0.9 1.2 1.9 1.0 1.4 -0.7 1.4 -0.4 -1.3
Commuting to job workplace: Cycle 0.3 0.3 0.6 0.2 -0.7 0.8 -0.6 0.2 0.5
Myopia 2.7 3.9 5.6 -2.0 -1.9 1.9 -1.9 -1.8 -2.4
Vascular/heart problems diagnosed by doctor 3.7 10.2 14.6 3.3 3.8 -3.1 3.8 3.2 1.4
Cholesterol lowering medication 4.3 6.3 8.9 -2.3 -2.5 2.8 -2.5 -3.0 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.8 0.5 -0.0 1.4 -0.0 0.0 1.2
Pain experienced in last month 0.9 1.5 3.0 1.2 1.2 -1.7 1.2 0.8 0.8
Supplements: Calcium 0.1 0.1 0.7 0.1 -0.0 -0.8 -0.1 0.1 0.1
Basal cell carcinoma (self-reported) 0.7 0.8 1.1 1.0 1.0 0.7 0.9 1.0 0.3
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.8 -1.0 -0.9 0.6 -0.9 -1.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 4.3 -1.4 -2.1 1.0 -2.1 -1.7 -1.0
Heart disease (siblings) 3.4 4.2 7.6 -2.1 -1.9 2.0 -2.0 -1.1 -2.8
Alcohol drinker status: Previous 0.5 0.5 2.6 -0.3 0.1 0.5 0.1 0.4 -1.6
Pack years of smoking 0.1 0.1 0.4 0.1 0.1 -0.2 0.2 -0.6 -0.3
Impedance of whole body 0.1 0.6 1.6 0.4 1.0 -1.3 0.9 0.5 0.0
Leg fat mass (left) 0.1 0.5 2.1 -0.6 -0.5 1.5 -0.4 0.3 -0.4
Arm predicted mass (left) 1.3 6.5 9.6 2.3 2.3 -3.1 2.4 2.3 2.8