Hub : Genes

FAM200B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3760	0.0440	0.0e+00	0.296	0.290	0.393	0.338	0.380	2.1e-36	1.6e-35	5.7e-51	1.7e-42	6.4e-49
2	GTEx	Artery Tibial	0.1631	0.0455	1.2e-05	0.104	NA	0.081	NA	0.081	1.7e-08	NA	6.1e-07	NA	7.0e-07
3	GTEx	Brain Cerebellum	0.2090	0.0810	8.2e-03	0.200	NA	0.178	NA	0.194	1.5e-06	NA	5.9e-06	NA	2.1e-06
4	GTEx	Brain Hypothalamus	0.4530	0.1140	1.9e-04	0.092	NA	0.112	NA	0.055	3.7e-03	NA	1.4e-03	NA	2.1e-02
5	GTEx	Muscle Skeletal	0.0825	0.0335	3.3e-03	0.033	NA	0.011	NA	0.018	3.3e-04	NA	2.4e-02	NA	6.5e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0557	0.0197	9.2e-04	0.016	0.022	0.034	0.025	0.046	3.2e-03	6.7e-04	3.2e-05	2.9e-04	1.3e-06
7	TCGA	Glioblastoma Multiforme	0.2890	0.1310	1.7e-03	0.067	0.108	0.067	NA	0.077	4.5e-03	3.7e-04	4.3e-03	NA	2.5e-03
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0415	0.0237	1.5e-03	0.050	0.019	0.035	NA	0.039	2.7e-06	2.9e-03	8.2e-05	NA	2.8e-05
9	TCGA	Brain Lower Grade Glioma	0.2093	0.0640	4.6e-09	0.023	0.070	0.081	NA	0.062	9.7e-04	2.4e-08	1.7e-09	NA	1.3e-07
10	TCGA	Pancreatic Adenocarcinoma	0.2210	0.1100	2.1e-03	0.000	0.057	0.016	NA	0.029	3.1e-01	2.1e-03	7.1e-02	NA	2.2e-02
11	TCGA	Testicular Germ Cell Tumors	0.2960	0.1330	1.3e-03	0.097	0.067	0.139	NA	0.084	2.6e-04	2.2e-03	1.3e-05	NA	6.6e-04
12	TCGA	Thyroid Carcinoma	0.0800	0.0430	2.9e-03	0.028	0.017	0.020	NA	0.022	8.2e-04	7.7e-03	4.3e-03	NA	2.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.6	0.9	4.3	1.0	0.7	0.8	0.6	-0.0	-0.1	1.3	1.2	0.4	2.1	1.1	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	1.6	0.1	0.5	-0.7	1.1	0.1	0.2	0.2	0.2	-0.3	0.6	-0.1	-1.3
Depressed Affect (Nagel 2018)	0.9	1.9	6.1	-1.7	-1.0	-0.8	0.3	-1.4	-1.8	-1.0	-0.3	-2.5	-0.8	1.0	-1.9
Depression (Nagel 2018)	2.5	3.7	9.9	-2.9	-1.4	-1.2	0.4	-1.4	-2.0	-2.2	-1.1	-3.1	-1.9	0.4	-2.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.3	1.1	0.2	1.0	-1.1	0.6	0.5	0.6	0.8	1.8	1.2	0.6	2.1
Neuroticism (Nagel 2018)	1.4	3.2	10.4	-2.4	-1.2	-0.9	-0.3	-2.0	-2.0	-1.1	-0.6	-3.2	-1.0	1.1	-2.8
Schizophrenia (2018)	0.3	0.7	2.2	-0.6	0.1	-1.5	1.0	0.1	0.4	-0.8	-0.7	-0.4	-1.2	-0.7	-1.3
Schizophrenia vs Biploar Disorder	3.3	4.4	8.8	-2.7	-1.5	-2.7	-0.9	0.7	-1.2	-2.3	-3.0	-2.7	-1.4	-2.8	-1.3
Worry (Nagel 2018)	3.0	6.2	14.1	-3.5	-2.2	-2.0	-1.2	-1.7	-2.3	-2.6	-2.1	-3.8	-1.9	-1.4	-3.6
Alzheimer’s Disease (in mother)	0.9	1.0	2.7	0.8	0.7	0.1	1.4	-0.4	1.0	1.2	1.1	-0.0	1.3	0.9	-1.6
Alzheimer’s Disease (in father)	0.9	1.0	3.1	1.1	1.7	0.1	-0.3	0.5	1.7	1.3	0.3	1.0	0.7	0.3	0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	3.1	1.3	1.1	0.2	0.7	0.5	1.8	1.5	1.0	1.0	1.4	0.9	-0.2
Crohns Disease (2017)	0.4	0.9	2.9	-1.7	-0.7	-1.2	-0.8	0.2	-0.7	-0.6	-0.9	-1.6	-0.2	0.4	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-1.2	-0.5	-0.4	-1.4	0.2	-0.3	-0.2	-0.5	-0.9	0.5	0.6	-0.5
Ulcerative Colitis (UC)	0.3	0.5	1.4	0.5	0.6	0.9	-0.6	0.2	0.8	0.7	0.7	1.0	1.2	0.6	0.4
Major Depression (MDD)	2.1	2.6	8.4	-2.4	-1.9	-2.9	-0.0	1.5	-1.0	-2.0	-2.0	-1.0	-0.4	-0.6	0.7
Reaction Time	0.5	0.9	2.5	0.4	1.6	1.1	1.6	-0.8	0.9	0.4	0.9	0.4	-0.3	1.1	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	5.7	-0.0	-0.5	0.6	-2.4	0.2	-0.4	-0.2	0.2	1.0	-0.1	0.5	1.3
Breast Cancer	0.4	0.9	2.3	0.6	1.3	0.5	1.2	-1.2	1.5	0.2	0.7	0.5	-0.5	-0.6	-1.3
Ovarian Cancer	0.2	0.3	0.9	0.8	0.3	0.1	-0.9	0.1	0.1	-0.3	0.0	0.7	-0.7	-0.4	0.2
Prostate Cancer	0.8	1.1	4.2	1.3	2.0	0.8	-0.7	-0.9	1.1	1.0	0.7	0.7	-0.0	-0.7	-1.5
Age at First Birth	0.2	0.2	0.7	0.9	0.0	-0.1	0.2	0.7	-0.3	0.5	0.3	0.5	-0.6	0.6	-0.1
Bipolar Disorder (2011)	0.7	0.7	5.3	0.2	0.2	-0.0	0.7	-0.4	-0.0	1.0	0.4	-0.4	2.3	-0.8	-0.5
Body Mass Index (BMI) (2010)	0.7	0.9	6.3	-0.3	-0.2	-1.3	-0.5	0.3	0.3	-0.2	-1.3	-0.5	-0.6	-2.5	-0.3
Coronary Artery Disease (CAD)	0.5	0.6	2.3	-0.9	-0.7	-1.0	-0.6	0.7	-0.3	-1.5	-0.8	-0.2	-0.8	0.2	-0.1
Crohns Disease (2012)	0.7	1.2	3.6	-1.6	-0.1	-0.7	0.3	-1.6	-0.3	-0.6	-0.8	-1.3	-0.5	-1.4	-1.9
Mean Putamen Volume	0.6	0.7	1.7	0.7	0.5	1.2	-0.3	-1.0	-0.1	1.3	1.0	-0.2	1.1	1.3	0.3
Fasting Glucose	0.3	0.3	1.1	0.3	0.3	0.1	0.1	0.5	0.8	0.4	0.6	0.5	0.8	1.1	-0.0
HbA1C	0.5	0.5	2.5	-0.4	-0.4	0.1	0.4	0.7	0.4	0.1	-0.0	-0.4	0.2	1.5	1.6
HDL Cholesterol	0.2	0.3	1.3	0.7	-0.2	1.0	-0.3	-0.1	-0.0	1.1	0.2	0.5	-0.2	0.2	0.1
LDL Cholesterol	0.4	0.6	2.0	-0.0	-0.5	-0.8	-0.8	1.4	0.3	-1.4	-0.6	-0.2	-0.5	-0.7	-1.0
Lupus	1.5	2.2	5.4	2.3	1.5	1.3	0.7	0.7	1.2	2.2	1.7	1.7	0.6	1.6	1.2
Neuroticism (2016)	0.4	0.6	2.1	-1.0	-0.6	-1.4	-0.2	0.7	-0.2	-0.6	0.0	-0.9	0.2	1.3	-0.8
Primary Biliary Cirrhosis	0.6	0.9	3.2	-0.9	-0.5	-1.8	0.2	1.2	-0.5	-1.2	-1.3	-0.5	-0.7	-1.0	0.4
Rheumatoid Arthritis	1.4	1.9	6.6	-0.8	-1.1	-1.7	-0.7	2.0	-0.7	-1.4	-1.7	0.1	-2.6	-0.4	1.0
Schizophrenia (2014)	0.4	0.8	2.8	-1.0	-0.2	-1.7	0.7	-0.0	-0.0	-0.3	-1.0	-0.9	-0.3	-1.0	-1.5
Triglycerides	0.3	0.4	2.2	0.7	0.9	0.2	0.5	0.2	1.5	0.1	0.5	0.7	0.4	0.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	4.7	0.1	0.1	0.1	-2.2	-0.3	-0.4	-0.8	-0.4	-0.8	0.7	-1.4	0.0
Ulcerative Colitis	0.4	0.6	3.0	-0.2	-0.4	0.8	-0.3	-0.1	-1.0	0.3	1.0	-0.5	1.7	1.1	-0.5
Blood Eosinophil Count	0.1	0.5	2.2	0.1	0.2	1.3	0.4	-1.5	-0.3	0.7	0.5	-0.7	-0.0	0.9	-0.1
Blood Platelet Count	0.0	0.4	1.3	-0.5	-0.3	0.1	0.1	-0.2	-1.0	0.3	0.2	-1.1	0.9	0.1	-1.1
Blood Red Count	1.3	12.2	53.0	1.5	-2.1	-0.0	-1.1	6.3	-0.8	2.6	1.3	1.7	0.3	7.3	5.8
Blood White Count	0.2	1.6	5.5	-0.5	-1.7	-0.9	0.1	2.4	-1.7	0.2	-0.3	-0.0	0.2	1.3	2.3
Heel T-Score	0.2	1.8	4.0	1.5	1.3	0.6	1.6	-0.3	1.5	2.0	1.6	1.5	1.4	1.2	0.5
BMI	0.2	1.0	4.5	0.4	-0.6	-1.3	0.6	2.1	-0.9	0.2	-0.9	0.2	0.6	-0.6	1.7
Height	0.1	2.2	5.6	0.3	-2.3	0.5	-1.9	1.8	-0.6	1.5	-0.4	-0.0	-0.2	2.4	2.4
Waist Hip Ratio (WHR)	0.4	2.0	4.8	-1.9	-1.3	-1.1	0.5	1.6	-2.2	-1.0	-0.9	-1.9	-1.8	0.8	-0.1
Systolic Blood Pressure	0.4	2.1	8.4	-1.5	-1.6	-1.1	0.9	0.1	-1.2	-2.9	-1.7	-1.0	-1.8	-1.2	0.6
Smoking Status	0.3	0.7	3.7	-1.0	0.3	-0.1	1.9	-0.5	0.9	-0.3	-0.2	-0.6	-1.0	0.5	-1.1
Allergy or Eczema	0.6	1.6	5.0	0.7	1.2	1.8	0.2	-2.2	1.5	1.4	1.1	0.1	1.9	-0.5	0.1
Cardiovascular Disease	0.4	1.3	2.9	-0.7	-1.5	-1.3	-1.3	1.1	-1.7	-1.0	-1.4	0.0	-0.7	-1.0	1.1
Hypothyroidism (self reported)	0.8	1.9	5.9	-0.9	-1.4	-1.5	-2.0	0.9	0.1	-1.3	-2.0	0.5	-2.4	-1.0	0.7
Respiratory disease	0.3	0.7	2.2	-1.5	-0.6	-0.6	0.1	-0.3	0.4	-0.8	-1.0	-0.8	0.6	-1.0	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.4	-1.3	-0.8	-0.4	1.8	-0.5	-1.0	-0.1	-0.2	-1.6	0.6	0.3	-1.2
Lung FEV1/FVC ratio	0.8	4.1	11.0	1.6	3.1	1.9	1.6	-3.3	2.2	1.8	1.9	1.1	2.3	-1.2	-0.6
Lung FVC	0.2	1.1	3.0	1.3	0.8	1.2	-1.0	-0.9	1.6	0.7	0.9	1.7	0.6	-0.4	0.3
Neuroticism	1.2	3.0	11.3	-2.2	-0.4	-0.6	0.8	-2.8	-1.1	-1.0	-0.3	-2.6	-1.1	0.5	-3.4
Chronotype (morning person)	0.8	2.0	6.7	-0.8	-0.8	-1.7	-2.6	1.6	-1.5	-1.8	-1.5	-0.7	-0.3	-1.3	-0.1
Hair Pigment	0.0	0.7	3.2	-0.6	0.6	0.8	0.8	-1.8	-0.1	-0.2	0.0	-1.1	-0.2	-0.6	-1.0
Tanning	0.1	1.1	5.5	0.9	-0.1	-1.0	-0.4	2.4	-0.4	0.3	0.2	0.8	0.5	1.7	1.3
Hand grip strength (left)	0.2	0.6	1.5	-0.6	-0.4	0.3	0.2	-1.1	-0.6	0.5	-0.2	-1.2	1.2	-0.7	-1.1
Number of treatments/medications taken	0.9	1.6	3.8	-1.9	-1.5	-1.6	-0.2	0.7	-1.2	-1.7	-0.9	-0.9	-1.4	1.3	-0.1
Average weekly spirits intake	0.4	0.5	2.4	-0.6	-0.8	-1.5	-0.0	1.1	-0.8	-0.4	-0.8	-0.6	-0.0	0.1	0.1
Sensitivity / hurt feelings	0.6	1.1	2.5	0.2	-0.0	1.5	1.3	-1.5	0.1	1.3	1.2	-0.5	-0.1	1.6	-0.6
Frequency of depressed mood in last 2 weeks	2.7	3.8	9.3	-2.5	-1.5	-0.9	0.2	-1.4	-2.4	-2.5	-0.6	-3.1	-2.2	0.6	-2.7
Hearing difficulty/problems: Yes	0.7	1.1	3.1	1.3	1.8	0.7	0.7	-0.6	1.7	0.6	0.7	1.3	-1.1	0.3	0.5
Relative age of first facial hair	0.6	1.3	3.1	-1.7	-1.7	-1.0	-0.1	-0.1	-0.9	-1.4	-1.7	-1.0	-0.4	-1.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.8	0.5	-0.1	-0.1	0.9	0.0	0.8	-0.6	0.4	1.5	-1.9	1.2	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.6	0.0	-0.3	-0.1	1.2	-0.2	0.4	-0.0	-0.3	0.4	-1.1	0.2	0.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.3	0.3	-0.7	-1.1	-0.1	1.3	0.1	-0.7	-1.2	1.2	-1.3	-0.6	1.5
Systolic blood pressure, automated reading	0.3	0.8	2.4	-0.7	-1.0	-0.8	0.9	0.4	-0.5	-1.6	-1.1	-0.3	-0.9	-0.5	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	2.7	-0.2	0.5	0.2	0.0	-1.6	-0.3	-0.0	0.1	-0.8	0.1	-0.5	-1.0
Angina	0.4	0.5	1.7	0.7	1.3	0.4	-0.2	0.2	0.3	1.0	0.8	0.5	0.6	1.1	0.6
Medication for hormone replacement therapy	0.6	0.7	2.0	-0.9	-1.4	-0.1	-0.3	-0.4	-0.7	-0.0	-1.1	-0.7	-1.4	-0.2	-0.8
Vitamin and mineral supplements	0.8	1.1	3.6	0.1	-0.9	-1.0	-0.4	1.9	0.8	-0.3	-0.9	1.5	-0.7	-0.6	1.6
Supplements: Zinc	1.8	2.0	5.8	-1.7	-1.4	-1.2	-1.4	0.6	-2.4	-1.1	-1.5	-2.0	-0.8	-0.3	-1.1
Medication: Co-codamol	0.7	0.8	2.6	-1.4	-1.3	-1.0	-0.4	0.8	-1.6	-0.7	-0.4	-1.1	-0.4	0.1	0.0
Medication: Metformin	0.6	0.9	2.9	-1.1	-0.6	-0.7	1.7	0.0	-1.2	-1.0	-0.1	-1.4	0.3	0.8	-0.7
Diabetes (father)	0.4	0.5	1.4	-0.6	-0.7	-0.7	1.1	-0.2	-0.4	-0.8	-0.8	-0.5	-0.1	-1.2	0.2
Diabetes (mother)	3.5	4.5	7.3	2.5	2.3	2.6	1.7	-0.9	2.7	2.7	2.6	1.8	2.1	1.6	-0.3
Severe depression (siblings)	0.3	0.3	1.6	-0.1	-0.3	0.3	0.6	-1.2	0.4	-0.4	0.3	-0.2	0.1	-0.1	-1.1
Pack years adult smoking proportion	2.3	3.6	7.3	-1.8	-2.4	-2.2	-1.3	2.7	-2.5	-1.1	-2.3	-1.7	-1.8	0.2	0.9
Impedance of leg (right)	0.2	1.2	4.1	-1.9	-0.7	-0.5	0.0	-0.4	-0.4	-2.0	-0.7	-1.0	-1.7	0.1	-1.0
Leg fat-free mass (left)	0.2	0.9	3.6	1.0	-0.8	-0.0	-1.0	1.6	-0.2	1.0	-0.5	0.8	0.5	0.1	1.9
Trunk fat percentage	0.2	0.9	3.9	-0.7	-0.6	-1.5	0.9	2.0	0.4	-0.6	-1.2	-0.2	-0.6	0.6	-0.1
Hand grip strength (right)	0.2	0.7	2.8	0.1	-0.1	1.0	-0.1	-0.8	-0.8	1.0	0.7	-0.9	1.7	0.4	-0.7
Townsend deprivation index at recruitment	0.8	1.2	6.7	-0.6	0.1	-1.6	0.2	2.6	0.7	-0.6	-0.8	0.5	0.4	0.5	1.5
Current tobacco smoking	0.2	0.3	2.1	-0.5	0.3	0.1	1.4	0.4	0.9	-0.3	-0.4	0.1	-0.2	0.3	0.4
Average weekly fortified wine intake	0.5	0.6	3.5	-0.4	0.7	0.6	-0.1	-1.9	-0.3	0.6	0.5	-0.4	0.0	-0.4	-1.1
Maternal smoking around birth	0.2	0.3	2.2	-0.5	-0.1	-0.3	1.5	-0.6	0.1	-0.0	-0.3	-0.4	-0.8	0.3	-0.6
Fed-up feelings	1.1	2.0	4.2	-1.7	-1.7	-1.3	0.0	-0.2	-1.2	-1.3	-1.4	-2.1	-1.8	-0.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	6.8	-2.4	-1.6	-1.2	0.6	-0.9	-1.8	-2.0	-1.2	-2.6	-2.2	0.2	-1.4
Relative age voice broke	1.2	1.8	5.8	-1.0	-2.0	-0.9	-0.3	0.2	-1.3	-1.1	-2.2	-1.4	-0.1	-2.4	0.1
Taking other prescription medications	0.5	0.7	1.8	-1.1	-0.3	-1.3	-0.6	-0.1	0.2	-1.2	-0.2	-0.5	-1.0	1.1	-1.3
Age when periods started (menarche)	0.5	1.3	7.0	-0.3	0.4	0.3	1.8	-2.7	0.8	-0.7	0.2	0.4	-0.0	-1.1	-1.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	-0.3	-0.4	-1.0	0.2	0.8	0.1	-0.2	-1.0	-0.1	-0.4	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.2	1.4	0.8	1.6	1.1	-1.1	1.4	2.1	1.2	1.2	1.8	0.6	1.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.7	0.1	-0.2	0.1	-0.8	0.3	-0.3	-0.7	-0.1	0.0	-0.5	-0.2	-0.4
Qualifications: CSEs or equivalent	2.0	2.6	7.2	-1.7	-1.9	-1.8	-1.1	1.0	-2.7	-1.2	-1.5	-2.7	-0.6	-0.5	-1.1
Serious illness, injury or assault to yourself	0.8	0.9	3.6	-1.8	-0.8	-0.6	0.3	-0.3	-0.3	-1.1	-1.0	-0.9	-1.9	0.3	-0.5
High blood pressure	0.6	1.7	4.6	-1.2	-1.5	-2.1	-0.9	0.9	-1.2	-1.7	-1.9	-0.4	-1.3	-1.0	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.1	0.8	0.5	1.5	0.5	-1.8	1.2	1.0	1.2	0.5	1.4	-0.3	-0.0
Multivitamins +/- minerals	0.7	0.9	4.4	-0.4	0.5	0.4	1.1	-2.1	-0.3	-0.2	0.5	-1.2	0.1	0.3	-1.5
Stomach or abdominal pain in last month	1.5	1.8	4.0	-1.9	-1.8	-2.0	-0.3	0.3	-1.9	-1.4	-1.4	-1.4	-0.7	-0.8	-0.6
Supplements: Glucosamine	2.3	3.0	6.8	2.4	2.3	2.4	1.1	-1.7	0.7	2.6	2.0	0.8	1.7	0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	2.2	-0.2	-1.5	0.1	-0.9	0.1	-0.0	-0.1	-0.7	0.4	-0.7	-1.4	0.4
Medication: Atenolol	0.3	0.4	0.8	-0.7	-0.4	-0.3	-0.9	-0.9	-0.6	-0.6	-0.7	-0.8	-0.4	-0.8	-0.0
Medication: Levothyroxine sodium	0.4	0.8	2.7	-0.1	-0.4	-0.9	-1.1	0.1	0.5	-0.1	-1.3	0.8	-1.6	-1.2	0.3
Sitting height	0.1	1.0	4.1	0.1	-1.2	0.8	-1.5	1.0	-0.1	0.4	-0.1	0.0	-0.8	2.0	1.1
Chronic bronchitis/emphysema (father)	1.0	1.2	5.3	0.4	0.7	1.0	1.5	-0.8	0.4	1.1	1.7	0.7	-0.3	2.3	0.2
High blood pressure (mother)	0.7	1.0	2.1	1.3	0.9	1.4	-0.8	-0.4	0.9	0.9	1.0	1.1	1.3	-0.2	0.8
Body mass index (BMI)	0.2	1.0	5.3	0.7	-0.2	-0.9	0.6	2.3	-0.1	0.6	-0.3	0.4	1.3	0.8	1.6
Impedance of leg (left)	0.2	1.1	3.4	-1.8	-0.3	-0.4	0.7	-0.5	0.1	-1.8	-0.5	-1.0	-1.5	0.2	-1.3
Leg predicted mass (left)	0.2	0.9	3.4	1.0	-0.9	-0.1	-1.1	1.6	-0.3	0.9	-0.6	0.8	0.4	-0.0	1.9
Trunk fat mass	0.2	0.7	4.1	-0.4	-0.7	-1.3	0.7	2.0	0.1	-0.4	-1.1	-0.1	-0.2	0.6	0.4
Waist circumference	0.2	0.7	3.5	-0.4	-1.0	-1.1	0.5	1.9	-1.0	-0.2	-1.0	-0.6	-0.1	0.3	0.6
Number of incorrect matches in round	0.3	0.5	1.8	-0.3	-0.1	0.2	1.2	-0.6	0.5	0.1	0.0	-0.8	0.9	-0.6	-1.3
Past tobacco smoking	1.1	2.0	7.4	0.7	-0.9	-0.4	-2.7	2.4	-1.5	0.4	-0.7	0.4	0.5	-0.7	2.4
Alcohol usually taken with meals	1.2	1.9	4.8	1.0	1.2	2.2	0.9	-2.1	1.3	1.6	1.8	0.4	0.8	1.6	0.1
Nervous feelings	0.3	0.6	2.4	-0.2	0.3	0.6	0.0	-1.3	-0.3	-0.1	0.8	-0.9	0.6	0.5	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	-0.2	-0.1	-0.0	0.7	-1.1	-0.1	-0.9	0.2	-0.8	0.1	0.2	-0.9
Hearing difficulty/problems with background noise	0.5	0.8	3.6	-1.3	0.2	-0.1	0.1	-1.6	0.5	-0.4	-0.2	-1.2	-0.8	0.0	-1.9
Hair/balding pattern: Pattern 2	1.1	1.5	3.6	-0.8	-1.8	-0.9	0.1	1.9	-1.3	0.1	-1.2	-0.5	1.5	-0.7	1.8
Had menopause	0.8	1.0	2.0	1.3	0.0	0.9	1.0	-0.0	0.6	1.4	1.0	1.1	-0.4	1.4	1.1
Had other major operations	0.2	0.3	0.6	-0.6	-0.7	-0.2	0.7	0.4	-0.5	-0.1	-0.1	-0.7	0.3	0.8	0.3
Forced vital capacity (FVC)	0.3	1.1	5.4	1.0	-0.7	0.7	-2.3	0.5	-0.3	0.6	0.2	0.7	1.5	-0.9	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.0	1.4	0.9	1.4	0.3	-0.2	1.0	2.0	1.4	1.6	1.9	1.3	1.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.1	1.4	0.4	1.4	0.1	-1.2	0.1	0.3	1.0	0.8	-0.9	1.2	1.1
Qualifications: None of the above	0.4	0.8	3.3	-0.6	0.7	-0.7	1.8	0.0	0.6	-0.3	0.4	-0.3	-0.8	1.4	-1.2
Financial difficulties in last 2 years	0.5	0.6	3.5	0.3	0.4	0.6	0.7	-0.2	-0.0	0.7	1.4	0.3	0.4	1.9	0.3
Mouth/teeth dental problems	0.4	0.6	1.9	1.4	0.5	1.1	0.4	0.1	0.5	0.4	0.8	1.4	0.5	0.5	0.5
Heart attack	0.5	0.7	2.2	0.4	0.4	0.9	0.4	-1.1	1.0	0.5	0.4	0.3	-1.5	0.4	-1.4
Allergy	0.1	0.3	1.0	0.2	0.1	-0.5	-0.3	1.0	-0.9	-0.1	-0.3	-0.3	-0.4	0.4	0.7
Pain all over the body in last month	1.1	1.2	3.4	-1.3	0.2	-1.1	-0.4	-0.8	0.5	-1.8	-1.2	-0.7	-1.0	-1.6	-1.3
Diabetes (self-reported)	0.4	0.7	2.1	-1.2	-0.9	-0.5	0.5	-0.3	-1.3	-0.6	-0.6	-1.5	0.6	0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.7	1.3	0.3	0.7	-0.5	0.1	0.9	0.2	0.5	1.1	0.6	-0.0	1.2
Medication: Ramipril	0.5	0.6	1.5	-0.7	-1.2	-0.9	-0.6	-0.4	-0.7	-0.9	-0.8	-0.5	-1.2	-0.5	0.0
Medication: Simvastatin	1.8	2.6	8.3	1.6	1.3	0.6	1.1	0.8	1.3	1.6	1.6	2.0	1.5	2.9	1.7
Fluid intelligence score	0.3	0.7	2.4	-0.1	0.2	1.2	-1.1	-0.5	0.5	-0.0	0.7	1.6	0.1	0.5	1.3
Illnesses of siblings	0.6	0.9	3.5	-0.6	1.1	-0.7	-0.4	-0.2	0.5	-0.9	-0.9	-0.4	0.2	-1.7	-1.9
Neuroticism score	0.9	1.9	5.6	-1.6	-0.7	-0.2	0.7	-2.3	-1.2	-0.7	-0.1	-2.2	-1.1	0.7	-2.4
Weight	0.2	0.9	4.2	0.8	-0.5	-0.4	0.2	2.0	0.1	0.6	-0.4	0.6	0.9	0.9	1.6
Impedance of arm (right)	0.5	2.1	6.3	-2.2	-0.7	-0.7	-0.6	-1.1	-0.4	-1.7	-1.0	-1.3	-2.3	-1.0	-2.5
Arm fat percentage (right)	0.2	0.9	2.6	-0.9	-0.8	-1.6	0.7	1.6	-0.6	-0.7	-1.3	-0.9	0.3	-0.1	-0.2
Trunk fat-free mass	0.2	1.2	6.1	1.4	-0.4	0.6	-0.8	0.9	-0.3	0.9	0.1	0.9	1.2	0.8	2.5
Hip circumference	0.1	0.6	2.4	1.0	-0.3	-0.4	0.4	1.5	0.6	0.8	-0.3	0.7	0.8	0.4	0.8
Time employed in main current job	0.7	0.8	2.9	-0.7	-1.2	-0.1	-1.3	0.4	-1.7	-0.6	-0.6	-1.4	0.1	-0.1	0.3
Alcohol intake versus 10 years previously	1.0	1.5	4.4	-1.2	-1.2	-1.1	-1.2	0.6	-0.6	-0.5	-2.1	-0.5	-2.0	-1.6	0.4
Father’s age at death	0.7	0.9	7.1	-0.3	-0.5	-0.3	-0.2	-0.0	0.9	-0.5	-1.1	0.0	0.8	-2.7	-0.1
Worrier / anxious feelings	1.2	2.3	8.5	-1.7	-0.8	-0.7	-0.8	-2.0	-1.0	-1.2	-1.0	-2.2	-1.3	-1.1	-2.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.9	-1.9	-2.0	-1.6	-1.1	0.3	-1.9	-2.2	-1.2	-1.8	-1.4	-0.4	-1.5
Falls in the last year	0.8	1.0	7.6	-0.7	0.7	-0.0	0.3	-2.8	-0.4	-0.7	0.7	-0.9	0.3	-0.1	-1.3
Hair/balding pattern: Pattern 3	0.5	0.7	2.1	0.6	0.3	1.0	0.1	-1.2	1.4	0.5	0.9	0.9	-0.7	0.3	-0.9
Number of live births	0.7	1.0	3.3	1.4	1.2	0.5	1.8	0.4	1.4	0.7	0.9	0.9	0.8	0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.3	1.6	0.1	1.6	-1.9	-0.7	-0.1	1.2	0.9	0.6	2.1	-0.8	0.9
Pulse rate	0.8	1.3	4.2	-1.4	-0.4	-2.1	-0.2	1.1	-0.2	-1.3	-1.5	-0.4	0.0	-2.0	-0.1
Happiness	2.5	3.0	16.7	-0.4	0.8	1.2	1.2	-4.1	0.1	-0.5	1.0	-1.8	0.3	0.1	-3.3
Noisy workplace	0.2	0.2	0.9	0.2	0.2	-0.4	-0.1	0.5	-0.2	-0.1	0.3	0.1	0.5	1.0	1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.7	0.4	-0.2	0.5	-1.9	-0.0	-0.7	-0.4	-0.3	-0.1	0.7	-1.9	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.8	-1.0	-1.0	-1.5	-1.0	1.4	-1.7	-1.5	-1.0	-1.4	-1.0	-0.0	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.9	6.1	-0.3	1.0	0.0	2.5	-1.2	0.8	-0.1	0.7	-0.1	-0.6	0.9	-0.5
Asthma	0.2	0.3	1.1	-0.9	-1.0	-0.5	-0.1	0.9	0.5	-0.3	-0.8	0.2	0.1	0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.6	-1.0	-0.1	-0.7	0.2	0.1	-0.1	-1.1	-1.3	-0.3	0.7	-1.1	0.9
Medication: Cholesterol lowering	0.2	0.3	2.1	-0.2	0.1	-0.2	-0.0	0.2	0.4	0.4	0.6	0.3	0.5	1.4	-0.6
Depression (self-reported)	2.7	3.2	8.7	-3.0	-1.7	-2.2	-0.7	-0.3	-1.5	-1.7	-1.8	-2.6	-1.3	-0.5	-2.1
Medication: Lansoprazole	1.4	1.6	4.5	-1.4	-1.4	-1.7	-1.1	0.1	-2.1	-0.8	-1.1	-1.8	-1.3	-0.3	-0.7
Prospective memory result	0.4	0.4	1.0	-0.6	0.6	-1.0	0.8	-0.0	0.4	-0.7	-0.6	-0.6	0.9	-0.9	-0.4
Lung cancer (father)	2.8	3.3	7.6	-2.7	-1.0	-2.8	0.0	1.3	-1.2	-2.6	-2.6	-1.3	-0.6	-2.2	-0.5
Illnesses of mother	0.3	0.3	0.9	-0.2	-0.5	-0.2	0.4	0.9	-0.5	0.7	-0.5	-0.5	0.5	0.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	6.2	1.2	-0.3	1.0	-2.5	-0.4	-0.3	1.0	0.2	0.3	1.8	-1.4	0.8
Pulse wave Arterial Stiffness index	0.7	0.9	2.7	-1.6	-0.7	-1.1	0.9	0.1	-0.9	-0.8	-1.1	-1.4	0.3	-0.5	0.2
Impedance of arm (left)	0.3	1.3	5.3	-1.5	-0.5	-0.2	-0.5	-1.0	-0.0	-1.3	-0.4	-0.8	-2.0	-0.4	-2.3
Arm fat mass (right)	0.2	0.8	4.7	-0.1	-0.8	-1.2	0.4	2.2	-0.4	0.0	-0.9	-0.1	0.6	0.5	0.9
Trunk predicted mass	0.2	1.2	6.3	1.4	-0.4	0.6	-0.9	1.0	-0.4	0.9	0.1	1.0	1.2	0.8	2.5
Standing height	0.0	0.3	1.0	0.1	-0.8	1.0	-0.9	-0.4	0.4	0.2	-0.3	0.3	-0.9	0.5	0.3
Length of working week for main job	0.2	0.2	0.6	-0.5	0.1	-0.6	-0.0	0.3	0.6	-0.7	-0.5	0.1	-0.4	0.3	0.1
Exposure to tobacco smoke at home	0.8	0.9	2.9	-1.2	-0.1	-1.1	1.7	0.9	-0.2	-0.1	-0.9	-1.1	1.5	-0.3	-0.1
Breastfed as a baby	4.3	5.3	14.3	2.9	2.3	2.3	1.2	-0.9	2.5	1.7	2.8	3.8	0.4	2.2	2.3
Tense / ‘highly strung’	2.8	4.7	10.8	-3.3	-1.9	-2.4	-0.6	-0.9	-2.2	-2.6	-1.7	-3.3	-1.1	-0.6	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	4.3	-1.6	-0.9	-0.2	-0.2	-1.6	-1.0	-0.6	-0.1	-2.1	-0.8	1.3	-1.3
Hair/balding pattern: Pattern 4	0.3	0.7	2.7	-0.6	1.6	-0.4	0.2	-1.4	0.9	-0.5	0.1	-0.5	0.9	-0.6	-1.1
Birth weight of first child	0.7	1.3	4.1	0.4	-0.4	0.6	-0.5	0.1	1.0	1.5	-0.3	0.9	1.7	-2.0	1.8
Peak expiratory flow (PEF)	0.3	0.7	2.1	1.4	0.6	1.1	-0.4	-0.5	-0.0	0.5	0.5	0.6	1.4	-0.4	1.0
Pulse wave reflection index	0.2	0.3	1.3	-0.6	-0.6	0.1	0.4	-0.5	-0.9	-0.1	-0.4	-1.1	0.2	0.1	0.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.5	-1.8	-1.2	-1.5	-1.6	0.1	-1.6	-1.1	-1.5	-2.1	-0.6	0.1	-0.5
Loud music exposure frequency	1.0	1.1	7.6	0.0	-0.7	-1.0	-0.4	1.2	-0.6	-0.4	-0.7	0.0	-2.8	0.7	0.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	9.4	-0.3	-1.3	-0.9	-3.1	2.4	-1.8	-0.3	-1.3	-0.4	0.7	-1.2	1.4
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	6.8	-2.6	-1.5	-2.5	-1.6	1.1	-1.6	-1.9	-2.2	-2.1	-0.6	-1.7	-0.7
Blood clot in the leg (DVT)	0.2	0.3	1.4	-0.4	-0.4	-0.7	1.2	0.7	0.0	-0.1	-0.7	0.0	-0.4	0.1	0.5
Medication: Paracetamol	0.5	0.8	2.1	-0.7	-1.1	-0.5	1.0	1.4	-1.2	0.4	-0.4	-0.6	0.8	0.6	1.4
Headache pain in last month	0.8	1.4	5.2	-0.1	-1.0	-0.4	-0.2	2.3	-1.1	0.5	-0.1	-0.4	1.8	0.9	2.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.6	1.0	0.6	1.0	-0.2	-0.2	0.2	0.5	0.3	0.3	0.3	-0.5	1.2
Glaucoma (self-reported)	0.5	0.6	2.0	-0.8	0.0	-0.7	-0.2	-0.8	-1.0	-0.6	-0.5	-1.4	0.1	-1.1	-1.0
Gout (self-reported)	0.6	0.8	2.3	-0.0	1.1	0.4	1.5	-0.5	1.5	0.5	0.6	0.1	1.4	0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.7	-0.7	-1.0	-1.3	-1.6	1.0	0.2	-0.8	-1.6	0.8	-1.9	-1.0	0.8
Medication: Amlodipine	0.5	0.8	1.9	1.2	1.3	1.4	1.0	-0.8	0.5	1.0	0.9	0.7	-0.1	-0.1	0.1
Medication: Ventolin 100micrograms inhaler	2.4	3.1	9.4	-2.5	-1.3	-2.6	-0.8	0.9	-0.3	-3.1	-1.8	-0.7	-1.7	-1.0	-2.0
Birth weight	0.6	1.3	4.6	1.4	0.8	1.5	0.1	-0.3	1.1	1.5	0.7	1.0	2.2	-0.0	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	-0.2	-0.7	0.4	0.3	-0.3	-0.9	-0.4	0.4	-0.6	0.3	0.2	-1.1
High blood pressure (siblings)	0.4	0.6	1.7	0.6	-0.6	1.1	-0.1	-1.3	0.1	1.1	0.7	0.3	-1.1	0.6	0.6
Forced vital capacity (FVC), Best measure	0.3	1.2	7.1	0.3	-1.4	-0.1	-2.7	0.9	-0.6	-0.0	-0.7	0.2	1.1	-1.4	0.9
Body fat percentage	0.2	0.9	4.4	-0.6	-0.6	-1.6	1.0	2.1	0.3	-0.6	-1.1	-0.2	-0.3	0.6	0.2
Leg fat percentage (right)	0.3	0.9	4.0	-0.5	-0.6	-1.5	1.3	2.0	-0.2	-0.7	-0.9	-0.3	0.5	0.6	0.5
Arm fat-free mass (right)	0.4	1.9	8.6	1.8	-0.3	0.6	-0.5	1.8	0.0	1.4	0.3	1.4	1.3	1.3	2.9
Exposure to tobacco smoke outside home	0.5	0.6	2.3	-0.9	-0.5	-1.0	-1.5	1.2	-0.7	-0.2	-0.6	-0.3	-0.5	0.1	0.7
Comparative body size at age 10	0.3	0.8	3.1	1.0	0.7	0.6	-0.4	0.4	0.3	1.1	0.7	0.9	1.8	0.0	1.2
Number of full brothers	0.7	0.9	2.6	-0.4	-1.6	-1.0	-0.8	1.6	-1.5	0.3	-0.8	-0.5	-0.1	-0.2	0.3
Worry too long after embarrassment	1.3	2.2	4.5	0.9	1.5	1.7	1.3	-2.0	0.9	1.4	2.1	-0.1	1.7	2.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	-0.3	-1.3	0.2	0.5	-0.4	-1.0	-0.6	0.4	-0.5	-1.0	1.3	-1.1
Wheeze or whistling in the chest in last year	1.3	2.4	7.8	-2.0	-0.8	-1.7	2.8	-0.4	-0.2	-2.0	-1.3	-1.1	-1.5	-0.8	-1.7
Number of children fathered	1.1	1.3	5.4	1.2	0.5	0.7	2.3	-0.7	1.4	1.1	1.3	1.2	0.3	1.0	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	1.0	1.2	0.5	0.5	-1.2	0.9	0.3	0.5	0.2	0.9	-1.2	-0.8
Age at first live birth	0.4	0.8	1.6	1.2	1.0	1.2	-0.7	-0.3	0.1	1.0	1.2	0.9	0.7	0.8	0.5
Pulse wave peak to peak time	0.8	0.9	2.4	1.5	0.6	1.2	-1.0	-0.3	1.0	0.7	1.1	1.5	-0.6	0.5	-0.3
Health satisfaction	1.9	2.5	4.6	-1.3	-1.9	-1.4	-1.3	-0.1	-1.5	-2.1	-1.7	-1.4	-1.9	-1.9	-1.4
Shortness of breath walking on level ground	1.8	2.1	4.4	-1.2	-2.1	-2.1	0.4	2.0	-1.5	-1.9	-1.2	-1.3	-0.6	0.7	-1.0
Qualifications: College or University degree	2.2	7.0	13.3	3.6	2.6	2.7	-0.7	-0.6	2.4	3.6	2.3	3.6	3.1	-0.2	3.0
Eye problems/disorders: None of the above	1.8	2.1	5.1	1.6	1.0	0.9	0.5	1.2	2.3	0.5	1.1	2.2	0.7	1.8	1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.9	5.5	-0.3	-0.6	-0.3	-2.4	0.9	-1.0	-0.4	-0.6	-0.8	0.0	0.1	1.2
Emphysema/chronic bronchitis	4.2	4.8	8.5	-2.9	-2.3	-2.3	-2.3	1.0	-1.7	-2.4	-2.4	-2.4	-1.8	-1.3	-2.7
Medication for pain relief, constipation, heartburn	0.2	0.3	2.1	0.4	-0.2	-0.0	-1.5	0.0	-0.2	-0.3	-0.1	-0.1	-0.8	-0.8	-0.5
Neck or shoulder pain in last month	0.7	1.0	2.8	-1.4	-1.2	-1.7	-0.1	1.0	-1.2	-0.7	-0.8	-1.0	-0.4	0.1	-0.5
Medication: Blood pressure	2.4	4.3	8.7	-3.0	-2.4	-2.8	-1.4	0.9	-1.6	-2.6	-2.5	-1.7	-2.4	-0.9	-1.2
Angina (self-reported)	0.3	0.4	1.5	0.7	1.2	0.4	-0.4	0.0	0.2	0.9	0.8	0.4	0.4	0.9	0.3
Migraine (self-reported)	0.6	0.8	2.2	0.2	-1.2	-0.4	-0.3	1.5	-1.2	0.6	0.2	0.2	0.9	1.0	1.4
Medication: Ibuprofen	0.6	0.7	1.8	-0.8	-0.4	-1.0	-0.1	1.0	-0.4	-1.2	-1.3	-0.3	0.6	-0.7	1.2
Medication: Allopurinol	1.0	1.3	4.8	0.8	1.1	0.7	1.6	-0.5	1.4	1.1	1.0	0.4	2.2	0.8	0.4
Medication: Omeprazole	1.0	1.2	3.1	-1.3	-0.8	-1.8	0.9	-0.2	-0.1	-1.4	-1.1	-0.4	-1.6	-1.3	-0.9
Medication: Seretide 50 evohaler	0.8	0.9	2.9	-1.4	-1.1	-0.9	-0.0	0.5	0.4	-1.7	-1.0	-0.8	-1.0	0.3	-0.8
Mean time to correctly identify matches	1.0	1.8	4.7	-0.1	1.8	1.1	2.2	-2.1	1.4	0.4	1.1	-0.1	-0.5	1.1	-1.9
Heart disease (mother)	1.2	1.5	5.2	-1.1	-1.7	-1.0	-1.0	1.0	-0.7	-2.3	-1.5	-0.1	-1.4	-1.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.6	-0.9	-0.1	-0.6	-0.7	-1.2	-0.6	-0.8	-1.1	-1.9	-1.5	-1.8	-1.5
Whole body fat mass	0.2	0.8	4.1	-0.3	-0.7	-1.4	0.6	2.0	0.0	-0.4	-1.1	-0.1	-0.0	0.5	0.6
Leg fat mass (right)	0.2	0.8	4.8	-0.0	-0.6	-1.1	0.7	2.2	-0.1	-0.2	-0.9	0.1	0.5	0.6	1.2
Arm predicted mass (right)	0.3	1.8	8.3	1.6	-0.6	0.4	-0.6	1.9	-0.2	1.3	0.1	1.2	1.2	1.1	2.9
Pulse rate, automated reading	1.1	3.7	9.5	-1.4	-1.9	-3.0	-0.5	3.1	-0.8	-2.7	-2.3	-0.0	-1.8	-1.8	0.5
Alcohol intake frequency.	1.2	2.7	16.0	-0.4	-1.5	-1.1	-1.4	4.0	-1.6	0.1	-1.0	-0.2	0.1	1.1	2.4
Comparative height size at age 10	0.1	0.3	1.6	0.2	-0.3	0.7	-0.4	0.3	0.3	0.8	-0.0	0.3	-0.2	0.7	1.3
Number of full sisters	0.4	0.5	1.3	0.9	0.2	0.3	0.5	1.1	0.2	0.7	1.1	0.9	-0.5	0.9	0.3
Suffer from ‘nerves’	0.6	1.0	2.4	-1.5	-0.8	-0.7	-0.1	-0.8	-0.8	-0.8	-0.6	-1.4	-1.1	-0.3	-1.5
Overall health rating	1.7	3.6	7.9	-2.2	-2.8	-2.6	-0.6	2.5	-2.3	-2.1	-1.8	-1.4	-1.3	-0.2	0.1
Chest pain or discomfort	1.1	1.6	4.2	-1.7	-1.1	-2.0	-0.2	1.8	-1.5	-0.8	-1.5	-1.2	-1.1	0.2	0.4
Had major operations	0.6	0.7	2.9	-0.6	-0.2	0.4	-0.5	-1.7	-0.2	-0.6	-0.0	-1.0	-0.1	0.7	-1.6
Age at last live birth	0.1	0.2	0.5	0.7	0.7	0.2	0.3	0.4	-0.0	0.4	0.5	0.6	0.6	0.3	0.1
Family relationship satisfaction	1.7	2.0	8.7	-1.1	-0.2	0.4	0.2	-3.0	-1.0	-0.9	-0.2	-2.5	-0.5	-0.2	-2.4
Leg pain on walking	0.3	0.4	1.1	0.6	1.0	-0.0	1.0	0.3	1.1	0.0	0.3	0.3	0.2	0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.1	-0.2	-0.3	0.1	0.4	0.6	0.7	-0.1	-0.0	0.6	-0.4	1.1	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	-0.2	-0.2	0.3	1.1	-0.1	-0.7	1.0	-0.0	-0.5	1.0	-0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	5.5	0.0	-0.4	-0.4	-1.3	0.3	0.1	-0.6	-0.9	0.5	1.0	-2.3	-0.0
Medication: Aspirin	0.0	0.1	0.2	-0.1	0.4	0.2	-0.2	0.1	-0.0	0.5	-0.0	0.0	0.4	0.3	0.2
Supplements: Vitamin C	0.9	1.0	3.3	-0.9	-1.1	-0.4	1.0	-0.5	-1.7	-1.2	-0.6	-1.8	-0.1	-0.0	-1.0
Knee pain experienced in last month	2.4	3.7	7.8	-2.5	-2.2	-2.6	-1.0	1.4	-2.1	-1.6	-2.8	-1.6	-0.4	-2.5	0.3
Hypertension (Self-reported)	0.6	1.5	4.5	-1.6	-1.2	-2.1	-0.6	0.4	-1.1	-1.7	-1.7	-0.6	-1.1	-0.9	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.8	-1.5	-1.7	-1.0	-0.9	-0.4	-1.2	-0.3	-1.0	-1.1	0.4	-1.5	-1.0
Illnesses of father: Heart disease	0.2	0.3	1.5	0.1	-0.4	0.1	0.4	-0.9	-0.1	-0.3	-0.0	0.1	1.0	-1.2	0.1
Illnesses of siblings: Diabetes	1.2	1.5	5.0	0.5	-1.5	0.6	-0.1	1.5	-1.7	1.3	0.5	-0.2	-0.2	1.8	2.2
Smoking status: Previous	1.3	1.9	8.5	-1.4	0.3	-0.3	1.7	-2.5	0.6	-0.6	0.1	-1.4	-0.7	-0.1	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.4	-0.6	-1.2	0.0	-1.0	0.6	-1.2	-0.6	-0.6	-0.8	-0.7	0.6	0.1
Whole body fat-free mass	0.2	1.1	5.3	1.2	-0.5	0.2	-0.9	1.4	-0.3	0.9	-0.3	0.9	1.0	0.4	2.3
Leg fat-free mass (right)	0.2	0.8	3.2	1.2	-0.5	0.2	-0.8	1.3	0.0	1.2	-0.3	0.9	0.6	0.2	1.8
Arm fat percentage (left)	0.2	0.7	3.4	-0.5	-0.8	-1.3	0.5	1.9	-0.5	-0.4	-1.0	-0.5	0.5	0.1	0.1
Average weekly red wine intake	1.5	2.2	8.4	-1.0	0.2	1.0	-1.2	-2.9	-0.7	-1.4	0.3	-1.5	-0.2	-1.1	-2.8
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.6	0.1	-0.4	0.7	-0.0	-0.1	-0.8	0.8	0.3	-0.8	1.3	-0.1	0.0
Mood swings	1.0	1.9	5.7	-2.0	-1.0	-1.5	0.3	-0.5	-1.3	-1.6	-1.1	-1.8	-2.4	0.2	-0.8
Loneliness, isolation	1.1	1.5	3.3	-1.6	-1.2	-0.9	0.9	-0.8	-1.8	-1.2	-0.9	-1.8	-1.1	-0.6	-1.2
Long-standing illness, disability or infirmity	2.7	4.2	9.4	-2.4	-2.5	-2.9	-0.1	1.1	-1.6	-3.1	-2.2	-1.5	-2.9	-0.4	-1.0
Ever had bowel cancer screening	0.6	0.6	3.1	-0.6	0.3	-0.8	0.2	-0.7	0.7	-0.1	-0.9	-0.6	0.5	-1.8	-1.1
Diabetes diagnosed by doctor	0.4	0.6	1.8	-1.1	-0.6	-0.6	1.0	-0.1	-1.3	-0.5	-0.3	-1.3	0.7	0.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	-0.5	-0.7	-1.0	0.4	1.0	-0.6	-0.2	-0.4	0.1	-0.1	-0.2	0.6
Friendships satisfaction	2.6	3.2	15.9	-0.5	1.3	1.0	2.2	-4.0	0.7	-0.4	1.5	-0.7	-0.8	1.3	-3.0
Qualifications: nursing, teaching	0.4	0.6	2.7	-0.1	-0.8	0.3	-0.4	0.5	-1.6	-0.2	-0.2	-0.2	0.7	-0.5	1.7
Commuting to job workplace: Walk	0.4	0.4	1.4	0.3	0.1	0.4	-0.6	-0.2	0.2	-0.1	0.9	0.2	1.2	1.1	0.8
Eye problems/disorders: Cataract	1.8	2.1	4.5	-1.8	-1.9	-1.4	-0.2	0.3	-2.1	-1.1	-1.5	-1.8	-1.0	-1.6	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.2	0.0	0.0	-0.5	-1.5	-0.7	0.5	1.1	-0.3	-0.5	0.9	-1.1	-1.3
Medication for cholesterol	1.2	1.8	5.5	1.3	1.8	1.1	0.7	-0.2	2.3	1.1	1.4	1.5	2.0	0.0	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	2.1	0.1	-0.0	0.2	-0.1	0.3	0.1	0.3	0.2	0.6	0.5	0.1	1.4
Back pain experienced in last month	0.0	0.1	0.3	-0.1	-0.2	-0.1	-0.2	0.1	-0.2	0.6	-0.1	-0.4	0.1	0.2	0.4
Mineral and other dietary supplements	0.3	0.4	2.0	0.6	0.1	0.0	-0.1	0.2	1.4	0.4	0.1	1.1	0.8	0.2	0.5
Breast cancer (self-reported)	2.0	2.4	5.0	-1.7	-1.9	-0.9	-1.7	-0.5	-2.1	-0.7	-1.3	-2.2	-1.4	-0.8	-2.0
Asthma (self-reported)	0.3	0.6	1.5	-1.2	-1.2	-0.8	-0.2	0.9	0.5	-0.6	-1.1	0.1	-0.4	-0.3	-0.1
Osteoporosis (self-reported)	0.5	0.6	2.1	0.3	0.2	0.9	1.4	-1.2	0.5	0.5	0.2	0.2	-0.8	-0.5	-1.2
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.4	-0.2	-0.5	0.3	0.9	-0.2	0.7	-0.2	0.6	0.2	-0.5	0.9
Medication: Aspirin	0.2	0.3	0.7	0.5	0.7	0.5	0.4	0.4	0.2	0.9	0.2	0.4	0.6	0.3	0.6
Medication: Gliclazide	0.9	1.0	3.4	0.4	1.3	0.8	1.8	-1.8	0.5	0.4	1.1	-0.2	0.0	0.3	-1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.1	0.2	-0.2	-0.8	0.8	-0.4	-0.3	-0.3	-0.1	-0.8	-0.1	-0.3
Smoking status: Current	0.4	0.6	4.2	-0.3	0.5	0.4	2.1	0.0	1.2	-0.3	-0.1	0.2	0.2	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	12.2	2.3	2.3	2.8	0.8	-2.3	1.5	2.5	3.0	0.9	3.5	0.9	-0.2
Whole body water mass	0.2	1.0	5.0	1.3	-0.6	0.3	-0.9	1.3	-0.2	1.0	-0.2	0.8	1.0	0.5	2.2
Leg predicted mass (right)	0.2	0.8	3.1	1.2	-0.4	0.2	-0.7	1.2	0.1	1.3	-0.3	1.0	0.6	0.2	1.8
Arm fat mass (left)	0.2	0.7	4.5	-0.1	-0.9	-1.2	0.4	2.1	-0.5	-0.1	-0.9	-0.1	0.5	0.5	0.8
Number of self-reported non-cancer illnesses	1.0	1.7	3.8	-1.6	-1.7	-2.0	-0.3	0.7	-1.4	-1.6	-1.4	-0.9	-1.5	0.5	-0.2
Average weekly champagne plus white wine intake	3.1	4.3	8.9	2.6	1.7	2.8	1.3	-1.9	2.1	2.7	2.5	3.0	0.8	0.8	0.6
Miserableness	0.6	1.0	2.5	0.1	-0.1	1.0	1.0	-1.6	-0.7	0.8	1.1	-1.1	0.6	1.6	-0.7
Guilty feelings	0.3	0.5	1.4	0.5	-0.3	0.4	-0.2	-0.6	-0.8	0.3	0.6	-0.5	-0.8	1.2	-1.2
Wears glasses or contact lenses	0.4	0.4	2.7	-0.3	-0.7	-0.5	-0.3	0.4	-1.6	-0.1	-0.2	-0.3	0.5	0.5	0.9
Ever taken oral contraceptive pill	2.2	2.5	5.1	2.0	1.3	1.5	1.2	-1.0	1.3	1.4	2.0	2.2	-0.1	2.3	1.4
Hearing aid user	0.4	0.5	2.1	0.4	-0.0	0.5	0.6	-0.3	0.2	0.9	0.9	0.1	1.1	1.5	0.2
Mother’s age at death	2.6	3.2	11.3	0.6	2.1	1.2	3.4	-2.1	3.2	1.4	1.1	1.0	1.1	-0.4	-0.8
Financial situation satisfaction	0.4	0.5	3.1	0.4	0.0	0.3	-0.8	-0.6	0.0	0.3	0.5	-0.8	-0.3	0.8	-1.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.6	-0.7	-0.4	-0.6	0.7	-0.1	-0.9	-0.9	-0.7	-0.6	-1.2	-0.8	0.0
Commuting to job workplace: Public transport	0.7	0.8	3.3	-0.4	1.0	-0.2	0.7	-1.8	1.3	-0.8	0.2	0.4	-1.3	0.3	-0.6
Eye problems/disorders: Glaucoma	1.3	1.6	4.9	-1.5	-0.7	-0.6	-0.3	-1.5	-1.4	-0.9	-0.5	-2.2	0.0	-1.2	-2.0
Medication: Blood pressure	0.5	0.9	3.1	-0.7	-1.0	-1.3	0.4	0.2	-1.4	-0.7	-1.0	-0.8	-1.8	-0.0	0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.4	-2.1	-0.6	-2.0	1.9	0.4	-0.3	-1.3	-1.3	-1.2	0.3	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.4	-1.1	-0.7	-0.8	0.1	0.1	-1.9	-0.9	-0.5	-1.7	-1.1	-0.1	-0.5
High cholesterol (Self-reported)	0.2	0.3	1.6	0.0	-0.3	-0.2	-1.3	-0.2	-0.7	-0.1	0.1	-0.2	-0.4	0.6	-0.8
Medication: Bendroflumethiazide	1.5	2.2	5.0	-1.3	-1.9	-2.2	-0.2	0.7	-1.9	-1.2	-1.8	-1.5	-2.0	-1.2	-0.6
Medication: Paracetamol	0.7	1.1	4.3	-0.4	-0.9	-0.8	0.7	2.1	-0.9	0.5	-0.5	-0.1	0.9	0.6	2.0
Medication: Lisinopril	0.5	0.6	4.2	0.1	-0.3	-0.5	2.1	0.4	0.5	0.1	0.2	0.4	0.7	1.2	0.4
Medication: Atorvastatin	0.6	0.7	2.3	-0.8	-0.7	0.2	-0.6	-1.2	-1.0	-0.8	-0.1	-0.9	-1.2	-0.1	-1.5
Illnesses of father: High blood pressure	0.8	1.0	2.0	-0.8	-1.3	-1.4	-1.4	1.1	-0.4	-1.2	-1.2	-0.6	0.1	-0.9	0.7
Alcohol drinker status: Never	2.3	2.8	10.6	1.8	2.1	2.0	0.3	0.5	0.7	2.0	1.9	0.9	3.2	0.6	1.4
Ever smoked	1.0	1.8	5.2	0.4	1.6	1.4	2.0	-2.3	1.6	0.4	1.3	0.2	0.3	0.6	-1.6
Basal metabolic rate	0.2	0.9	4.6	1.1	-0.5	0.1	-0.6	1.5	-0.1	0.9	-0.3	0.8	0.9	0.5	2.1
Leg fat percentage (left)	0.3	1.0	3.9	-0.5	-0.4	-1.6	1.7	2.0	-0.0	-0.6	-0.9	-0.4	0.5	0.5	0.4
Arm fat-free mass (left)	0.2	1.0	4.8	1.0	-0.8	-0.2	-0.6	1.7	-0.2	0.7	-0.4	0.7	0.8	0.7	2.2
Number of operations (self-reported)	0.3	0.5	1.1	-1.1	-0.8	-0.5	0.7	-0.9	-0.4	-0.9	-0.6	-0.6	-0.6	0.4	-0.3
Average weekly beer plus cider intake	1.1	1.6	3.9	-1.9	-1.7	-2.0	-0.1	0.0	-1.4	-1.5	-1.1	-1.5	-0.7	-0.7	-0.6
Irritability	0.9	1.5	5.8	-2.2	-0.8	-1.0	-0.2	-1.0	-0.8	-1.2	-0.8	-2.4	0.1	0.9	-1.2
Risk taking	1.2	1.8	5.8	1.2	0.2	0.5	-0.3	1.5	0.9	1.7	1.0	1.5	1.3	2.4	1.8
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.0	-1.5	-0.6	-0.7	0.5	-0.5	-0.3	-0.9	-0.7	-1.7	0.2	-0.8	-1.7
Fractured/broken bones in last 5 years	0.4	0.5	2.0	0.7	1.3	-0.1	0.7	-0.5	1.4	-0.1	0.2	0.7	-0.6	0.8	0.3
Age started oral contraceptive pill	0.6	0.7	1.8	1.2	0.4	0.6	1.0	0.2	0.7	1.0	0.5	1.3	0.1	0.4	1.3
Diastolic blood pressure, automated reading	1.2	3.7	7.1	-1.4	-2.7	-2.3	-2.3	2.4	-1.4	-2.5	-2.2	-0.0	-1.3	-1.4	1.8
Ever depressed for a whole week	0.8	1.0	2.0	0.9	1.1	1.2	0.7	-1.3	0.9	0.6	1.4	1.1	-0.2	1.2	0.6
Unable to work because of sickness or disability	0.2	0.3	1.2	-0.1	0.6	-0.6	0.7	0.6	0.1	-0.1	0.2	-0.7	-0.3	1.1	-0.5
Commuting to job workplace: Cycle	1.9	2.3	5.9	2.4	1.3	1.8	-0.7	0.1	2.1	1.0	1.6	2.2	0.2	1.2	1.5
Myopia	0.5	0.7	1.8	0.5	1.3	1.3	0.1	-0.9	0.9	0.5	1.0	0.4	-0.2	1.1	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	0.7	1.1	1.5	0.9	-0.8	0.9	1.1	1.2	0.0	1.1	0.3	-0.4
Cholesterol lowering medication	0.3	0.4	1.4	-0.1	0.4	0.2	1.2	-1.0	-0.5	-0.4	0.2	-0.7	0.5	0.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.2	-2.0	-1.2	-2.0	0.6	-0.5	-0.9	-1.6	-1.4	-1.0	-1.8	-1.7	-1.1
Pain experienced in last month	1.3	2.2	6.1	2.5	1.3	2.2	0.3	-1.0	1.1	1.1	1.8	2.0	-0.9	1.2	-0.1
Supplements: Calcium	1.7	1.9	3.5	-1.7	-1.5	-1.5	-0.6	1.3	-1.3	-1.8	-1.8	-1.2	-1.9	-0.5	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	2.2	0.1	0.5	0.2	0.6	0.7	0.0	0.7	0.5	0.3	0.3	1.5	0.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	0.6	0.6	1.1	0.6	-1.2	1.2	0.7	0.7	0.6	-1.4	0.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	-0.7	-0.5	-0.9	1.0	0.7	-0.1	-0.2	-0.9	-0.4	-0.6	-0.2	0.0
Heart disease (siblings)	0.6	0.7	1.8	0.9	-0.2	0.3	-0.1	0.6	0.2	0.2	0.5	1.0	-1.4	1.3	1.3
Alcohol drinker status: Previous	0.8	0.9	2.5	-0.7	-0.9	-1.1	-1.0	1.3	-0.4	-0.7	-1.6	-0.5	-1.4	-0.9	0.2
Pack years of smoking	2.7	4.0	7.4	-1.8	-2.6	-2.4	-1.3	2.7	-2.7	-1.4	-2.4	-1.8	-1.9	-0.0	0.9
Impedance of whole body	0.3	1.6	5.4	-1.9	-0.3	-0.3	-0.1	-0.9	0.3	-1.7	-0.6	-0.8	-2.3	-0.2	-2.2
Leg fat mass (left)	0.2	0.8	4.8	0.1	-0.5	-1.1	1.0	2.2	-0.1	-0.1	-0.8	0.1	0.6	0.5	1.1
Arm predicted mass (left)	0.2	1.1	5.3	1.3	-0.5	0.2	-0.3	1.6	-0.0	1.1	-0.2	1.0	1.0	0.7	2.3